Any antagonist of lymphocyte function-associated antigen-1
ChEBI ID: 133024
| Member | Definition | Class |
|---|---|---|
| sar 1118 | An N-acyl-L-alpha-amino acid obtained by formal condensation of the carboxy group of N-[2-(1-benzofuran-6-carbonyl)]-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid with the amino group of 3-(methanesulfonyl)-L-phenylalanine. Used for treatment of keratoconjunctivitis sicca (dry eye syndrome). | lifitegrast |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 24 (57.14) | 24.3611 |
| 2020's | 18 (42.86) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 10 (23.26%) | 5.53% |
| Reviews | 10 (23.26%) | 6.00% |
| Case Studies | 1 (2.33%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 22 (51.16%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Integrin alpha-L | Homo sapiens (human) | IC50 | 0.0415 | 2 | 2 |
| Integrin beta-2 | Homo sapiens (human) | IC50 | 0.0415 | 2 | 2 |
| Intercellular adhesion molecule 1 | Homo sapiens (human) | IC50 | 0.0287 | 3 | 3 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |