triazoles has been researched along with piperidines in 255 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (5.88) | 18.7374 |
| 1990's | 28 (10.98) | 18.2507 |
| 2000's | 77 (30.20) | 29.6817 |
| 2010's | 100 (39.22) | 24.3611 |
| 2020's | 35 (13.73) | 2.80 |
| Authors | Studies |
|---|---|
| Kluge, S; Menzel, G | 2 |
| Cardillo, R; DiMuzio, J; Post, TJ; Raible, DG; Schulman, ES | 1 |
| Braquet, C; Köpernik, W; Mest, HJ; Rein, T; Riedel, A | 1 |
| Orsetti, M; Sorba, G | 2 |
| Braquet, P; Esanu, A; Hosford, D; Laurent, JP; Martin, C; Pommier, J; Rolland, A | 1 |
| Pounder, RE; Smith, JT | 1 |
| Caputo, E; Mela, GS; Savarino, V; Villa, G; Zentilin, P | 1 |
| Ernst, T; Gennoni, M; Halter, F; Merki, HS; Roehmel, JJ; Varga, L; Wilder-Smith, C; Zeyen, B | 1 |
| Gavey, C; Nwokolo, CU; Pounder, RE; Smith, JT | 1 |
| Holmfield, JH; Johnston, D; Primrose, JN; Rogers, MJ | 1 |
| Humphray, JM; Reeves, JJ; Stables, R | 1 |
| Büyüktimkin, N; Keller, F; Schunack, W | 1 |
| Johnston, DA; Wormsley, KG | 1 |
| Fuji, K; Kagiya, T; Mori, T; Murayama, C; Nagao, Y; Nishimoto, S; Ochiai, M; Sano, S; Sasai, K; Shibamoto, Y | 1 |
| Krämer, I; Schunack, W; Wegner, K | 1 |
| Bonjean, J; Schunack, W | 1 |
| Bonjean, VJ; Schunack, W | 1 |
| Orsetti, M | 1 |
| Baiocchi, L; Frigerio, A; Giannangeli, M; Palazzo, G | 1 |
| Bennett, JW; Ma, OH; Orth, RE; Young, L | 1 |
| Daly, MJ; Humphray, JM; Stables, R | 1 |
| Emami, S; Gespach, C; Menez, I; Rosselin, G | 1 |
| Emami, S; Gespach, C; Menez, I | 1 |
| Sussman, N | 1 |
| Clapham, J; Kilpatrick, GJ | 1 |
| Chmielewski, PA; Dudchenko, P; Holley, LA; Miller, JA; Sarter, M | 1 |
| Baker, R; Cascieri, MA; Chambers, MS; Hargreaves, RJ; Haworth, K; Keown, LE; Ladduwahetty, T; MacIntyre, DE; Metzger, JM; Owen, S; Rycroft, W; Sadowski, S; Seward, EM; Shepheard, SL; Swain, CJ; Tattersall, FD; Watt, AP; Williamson, DW | 1 |
| Heptinstall, S; Lösche, W; Sanderson, HM; Vickers, J | 1 |
| Balsa, D; Ferrando, R; Forn, J; Garcia-Rafanell, J; Giral, M; Merlos, M | 1 |
| Kampuis, DJ; Matroos, GE; Van Harten, PN | 1 |
| Baker, R; Ber, E; Cascieri, M; Francis, B; Hargreaves, RJ; Hill, RG; Keown, L; Ladduwahetty, T; MacIntyre, DE; MacLeod, AM; Merchant, K; Metzger, J; Pearce, D; Rycroft, W; Swain, C; Tattersall, FD | 1 |
| Higuchi, S; Isobe, Y; Kijima, H; Muramatsu, M; Suzuki, M; Yokomori, S | 1 |
| Bax, WA; Ferrari, MD; MaassenVanDenBrink, A; Reekers, M; Saxena, PR | 1 |
| Centemeri, C; Ciceri, P; Colli, S; Nicosia, S; Tosarello, D | 1 |
| Bertaccini, G; Coppelli, G; Coruzzi, G; Poli, E; Pozzoli, C | 1 |
| Hopkins, B; McHarg, A; Melrose, H; Napier, C; Stewart, M; Wallis, R | 1 |
| Deleu, D; Hanssens, Y | 2 |
| Allen, C; Bomhof, M; Legg, N; Patel, K; Paz, J; Vandormael, K | 1 |
| Goadsby, PJ | 1 |
| Brunsden, AM; Grundy, D | 1 |
| Bartlett, MG; Stewart, JT; Vishwanathan, K | 1 |
| Logemann, CD; Rankin, LM | 1 |
| Canapa, A; Canestrari, S; Damiani, E; Greci, L; Kalinska, B; Olmo, E; Wozniak, M | 1 |
| Bartleson, JD | 1 |
| Tfelt-Hansen, P | 1 |
| Borch, RF; Freel Meyers, CL | 1 |
| Kou, JH; Saha, P | 1 |
| Potrebic, S; Raskin, NH | 1 |
| Cho, W; Fujimura, M; Kim, KP; Kita, T; Kurashima, K; Leff, AR; Munoz, NM; Myou, S; Nakao, S; Nonomura, A; Sano, H; Shioya, T; Zhu, X | 1 |
| Bertinaria, M; Brenciaglia, MI; Di Stilo, A; Dubini, F; Gasco, A; Scaltrito, MM; Sorba, G | 1 |
| Hashimoto, S; Iwata, M | 1 |
| Marcus, DA | 1 |
| Goadsby, PJ; Jiang, K; Lines, CR; Lipton, RB; Massiou, H; McCarroll, KA; Pascual, J; Vandormael, K | 1 |
| Adelman, JU; Diener, HC; Ferrari, MD; Lines, CR; Lipton, RB; McCarroll, KA; Vandormael, K | 1 |
| Diener, HC; Fritsche, G; Katsarava, Z; Limmroth, V; Muessig, M | 1 |
| Freitag, FG | 1 |
| Stephenson, J | 1 |
| Fité, B; López-Gil, A; Pascual, J | 1 |
| Ichinowatari, G; Ohuchi, K; Tanimoto, A; Tsuyuki, K; Yaginuma, H; Yamada, M | 1 |
| Rapoport, AM; Sheftell, FD; Tepper, SJ | 1 |
| Eppinger, E; Meinhardt, G; Schmidmaier, R | 1 |
| Bussone, G; D'Amico, D; Gerth, W; Lines, CR; McCarroll, KA | 1 |
| Bojinov, V | 1 |
| Adelman, JU; Lewit, EJ | 1 |
| Allen, C; Evans, DC; Evers, R; Hargreaves, R; Lake, BG; O'Connor, D | 1 |
| John, GW; Létienne, R; Verscheure, Y | 1 |
| Foroumadi, A; Moshafi, MH; Rezaee, MA; Soltani, F | 1 |
| Brown, B; Dyck, B; Goodfellow, VS; Grey, J; Haddach, M; Naeve, GS; Phillips, T; Rowbottom, M; Saunders, J | 1 |
| Ashcroft, DM; Millson, D | 1 |
| Iizuka, T; Sakai, F | 1 |
| Konishi, S; Rusakov, D; Saitow, F; Satake, S | 1 |
| Gary, JJ; Scarbecz, M; Tran, NH | 1 |
| Jähnichen, S; Pertz, HH; Radtke, OA | 1 |
| Boot, JR; Broadmore, RJ; Cooper, J; Eyre, TA; Mitchell, SN; Pullar, IA; Sanger, GJ; Wedley, S | 1 |
| Kowa, H; Nakashima, K; Takeshima, T | 1 |
| Morillo, LE | 2 |
| Muñoz, P; Pascual, J | 1 |
| Adolfs, TJ; Borst, AJ; Coolen, HK; de Looff, W; Keizer, HG; Kruse, CG; Lange, JH; McCreary, AC; van Stuivenberg, HH; Veerman, W; Verveer, PC; Wals, HC | 1 |
| Edvinsson, L; Ingemansson, R; Jarvius, M; Malmsjö, M; Wackenfors, A | 1 |
| Healey, PJ; Mullins, CD; Perfetto, EM; Subedi, PR; Weis, KA | 1 |
| Hough, LB; Lu, Q; Montero, MJ; Nalwalk, JW; Shan, Z; Svokos, K; Wentland, MP | 1 |
| Alkorta, I; Alsasua, A; Cuberes, MR; Dannert, MT; Dordal, A; Frigola, J; Goya, P; Hernandez-Folgado, L; Holenz, J; Jagerovic, N; Martín, MI | 1 |
| Auvin, S; Cuvellier, JC; Joriot, S; Vallée, L | 1 |
| Bédard, PJ; Calon, F; Di Paolo, T; Dridi, M; Hadj Tahar, A; Meltzer, LT; Morissette, M | 1 |
| Abellán, G; Bilbao, A; Cippitelli, A; Gómez, R; Goya, P; Hernández-Folgado, L; Jagerovic, N; Macias, M; Navarro, M; Pavon, FJ; Rodríguez de Fonseca, F; Rodríguez-Franco, MA; Serrano, A | 1 |
| Day, YJ; Kern, JA; Li, Y; Linden, J; Liu, L; Oskouian, RJ; Rieger, JM | 1 |
| Attoub, S; Bruyneel, E; Emami, S; Gespach, C; Grijelmo, C; Nguyen, QD; Rivat, C; Rodrigue, CM; Rodrigues, S | 1 |
| Agama, K; Antony, S; Cushman, M; Hollingshead, M; Ioanoviciu, A; Kohlhagen, G; Morrell, A; Nagarajan, M; Pommier, Y | 1 |
| Axelrod, S; Bielory, L | 1 |
| Einav, S; Galun, E; Linden, J; Matot, I; Rivo, J; Zeira, E | 1 |
| Galzi, JL; Hachet-Haas, M; Kellenberger, E; Parmentier, M; Rognan, D; Springael, JY | 1 |
| Awad, AS; Huang, L; Li, L; Linden, J; Lobo, PI; McDuffie, M; Okusa, MD; Sevigny, CP | 1 |
| Klein, HH; Meier, JJ; Schmidt, WE | 1 |
| Cavalheiro, EA; Naffah-Mazzacoratti, Mda G; Peres, MF; Senne Soares, CA; Vieira, DS; Zukerman, E | 1 |
| Basso, AD; Black, S; Kirschmeier, P; Liu, G; Liu, M; Long, BJ; Marrinan, CH; Robert Bishop, W; Taylor, SA | 1 |
| Cao, Z; Hurley, DJ; Linden, J; Moore, JN; Murray, TF; Sun, WC; Vandenplas, ML | 1 |
| Kondo, M; Saita, Y; Shimizu, Y | 1 |
| Agrafiotis, DK; Connolly, PJ; Farnum, M; Lobanov, VS; Shemanarev, M | 1 |
| Awad, AS; Linden, J; Liu, L; Okusa, MD; Rosin, DL; Rouse, M; Sedor, JR; Vergis, AL | 1 |
| Dioszegi, M; Ji, C; Kondru, R; Mirzadegan, T; Rotstein, D; Sankuratri, S; Zhang, J | 1 |
| Billington, RA; Blasi Roman, CR; Canonico, PL; Carraro, L; Ercolano, E; Galli, U; Genazzani, AA; Sorba, G; Tron, GC | 1 |
| Bermúdez-Silva, FJ; de Fonseca, FR; Goya, P; Hernández-Folgado, L; Jagerovic, N; Macías, M; Pavón, FJ; Pérez-Valero, V; Serrano, A | 1 |
| Kruse, CG; Lange, JH | 1 |
| Lewis, JW; Tipton, DA | 1 |
| Barber, CG; Blakemore, DC; Chiva, JY; Eastwood, RL; Middleton, DS; Paradowski, KA | 1 |
| Augustyns, K; Chen, X; De Cock, H; De Meester, I; Dubois, V; Lambeir, AM; Scharpé, S; Van der Veken, P; Van Ginneken, C | 1 |
| Argyrakopoulou, G; Doupis, J | 1 |
| Jin, M; Koizumi, S; Linden, J; Odashima, M; Ohnishi, H; Otaka, M; Watanabe, S | 1 |
| Cox, JM; Edmondson, SD; Eiermann, GJ; He, H; Lyons, KA; Mastracchio, A; Patel, RA; Patel, SB; Petrov, A; Roy, RS; Scapin, G; Thornberry, NA; Weber, AE; Wu, JK; Xu, S; Zhu, B | 1 |
| Chen, JF; Chiodi, V; Domenici, MR; Ferrante, A; Frank, C; Ledent, C; Martire, A; Pepponi, R; Popoli, P; Tebano, MT | 1 |
| Jamieson, DG | 1 |
| Maren, K; Rojkjaer, L; Skerjanec, A; Wang, J | 1 |
| Berghaus, LJ; Hurley, DJ; Linden, J; Moore, JN; Sun, WC; Thompson, R; Vandenplas, ML | 1 |
| Cedergreen, N; Nørgaard, KB | 1 |
| Ellis, MC; Lane, AG; Miller, PC; O'Sullivan, CM | 1 |
| Cefalu, WT | 1 |
| Borthwick, AD | 1 |
| Kuritzky, L | 1 |
| Charvet, C; Mast, N; Pikuleva, IA; Stout, CD | 1 |
| Scheen, AJ | 2 |
| Gerich, J | 1 |
| Boudes, P; Viereck, C | 1 |
| Bunck, M; Gaburro, S; Hauschild, M; Landgraf, R; Sartori, SB; Singewald, N | 1 |
| Jeong, YT; Kabilan, S; Ramachandran, R; Rani, M; Senthan, S | 1 |
| Arun, B; Brown, PH; Castiglione, M; Cuzick, J; DeCensi, A; Dunn, B; Forbes, JF; Glaus, A; Howell, A; Vogel, V; von Minckwitz, G; Zwierzina, H | 1 |
| Bourdel-Marchasson, I; Dejager, S; Schweizer, A | 1 |
| Gmeiner, P; Hübner, H; Kühhorn, J | 1 |
| Abrol, R; Goddard, WA; Kudo, W; Nair, N; Reddy, VP; Smith, MA | 1 |
| Attkins, N; Bateman, L; Bictash, M; Doyle, R; Ivarsson, M; Neal-Morgan, S; Pullen, N; Ramsey, S; Russell, R; Turner, J; Weibley, L | 1 |
| Alter, M; Chaykovska, L; Fuchs, H; Heiden, S; Hocher, B; Klein, T; Rahnenführer, J; Runge, F; von Websky, K | 1 |
| Almansour, AI; Arumugam, N; Ashraf Ali, M; Choon, TS; Elumalai, K; Ismail, R; Kumar, RS; Osman, H; Singh, A | 1 |
| Barbee, T; Correa, I; Fredrickson, J; Gibbs, JP; Gibbs, MA; Lin, SL; Smith, B | 1 |
| Ball, RG; Bednar, RA; Bogusky, MJ; Breslin, MJ; Cabalu, TD; Coleman, PJ; Cox, CD; Cui, D; Doran, SM; Fox, SV; Garson, SL; Gotter, AL; Harrell, CM; Hartman, GD; Lemaire, W; McGaughey, GB; Prueksaritanont, T; Reiss, DR; Renger, JJ; Schreier, JD; Stellabott, J; Stevens, J; Tannenbaum, PL; Whitman, DB; Winrow, CJ; Young, SD | 1 |
| Edwards, KL; Irons, BK; Stapleton, MR; Weis, JM | 1 |
| Cao, Y; Chai, X; Jiang, Y; Sun, Q; Wu, Q; Yang, G; Yu, S; Zhang, D; Zhang, J; Zou, Y | 1 |
| Ishikawa, M; Yamada, Y | 1 |
| Bakris, GL; Flynn, C | 1 |
| Akahoshi, F; Ishii, S; Kadowaki, T; Kishida, H; Miyaguchi, I; Nabeno, M; Tanaka, Y | 1 |
| Aaltonen, N; Häyrinen, J; Käsnänen, H; Korhonen, J; Kuusisto, A; Laitinen, JT; Laitinen, T; Lehtonen, M; Navia-Paldanius, D; Nevalainen, T; Pantsar, T; Pasonen-Seppänen, S; Poso, A; Ribas, CR; Rönkkö, J; Savinainen, JR; Takabe, P | 1 |
| Ayaori, M; Iizuka, M; Ikewaki, K; Iwakami, N; Komatsu, T; Murakami, T; Nakaya, K; Ogura, M; Sasaki, M; Sato, H; Takase, B; Takiguchi, S; Uto-Kondo, H; Yakushiji, E; Yogo, M | 1 |
| Blake, RA; Boggs, J; Callow, M; Chan, E; Choo, E; Costa, M; Diaz, D; Firestein, R; Holsworth, DD; Korinek, V; Krauss, S; Lau, T; Machon, O; Magnuson, S; Merchant, M; Polakis, P; Sambrone, A; Schutten, M; Waaler, J | 1 |
| Binns, J; Bowlby, MR; Brunner, J; Cannon, CE; Coleman, PJ; Eddins, DM; Fox, SV; Garson, SL; Gotter, AL; Hodgson, R; Kuduk, SD; Mcdonald, TP; Renger, JJ; Savitz, AT; Stevens, J; Tannenbaum, PL; Tye, SJ; Uslaner, JM; Wang, X; Winrow, CJ; Yao, L | 1 |
| Alen, F; Crespo, I; de Fonseca, FR; de Heras, RG; Goya, P; Jagerovic, N; Orio, L; Ramírez-López, MT | 1 |
| Dowsett, M; Gao, Q; Isacke, CM; Mackay, A; Martin, LA; Morandi, A; Pancholi, S; Plaza-Menacho, I; Robertson, D; Zvelebil, M | 1 |
| Charbonnel, B; Dejager, S; Schweizer, A | 1 |
| Crow, JM | 1 |
| Czajkowska, B; Krzystanek, M; Lapray, D; Markowski, G; Pałasz, A; Peyron, C; Rojczyk-Gołębiewska, E; Skowronek, R; Wiaderkiewicz, R | 1 |
| Bowlby, MR; Brunner, JI; Coleman, PJ; Fox, SV; Garson, SL; Gotter, AL; Hargreaves, R; Hodgson, R; Kuduk, SD; McDonald, TP; Renger, JJ; Savitz, AT; Tannenbaum, PL; Tye, SJ; Uslaner, JM; Winrow, CJ; Yao, L | 1 |
| Castro, RN; de Lima, ME; de Nazareth Sá Diniz, J; Franklim, TN; Freire-de-Lima, L; Mendonça-Previato, L; Previato, JO | 1 |
| Darandale, SN; Mulla, NA; Pansare, DN; Sangshetti, JN; Shinde, DB | 1 |
| Huang, Q; Peng, Y; Wang, Y; Zhao, L | 1 |
| Berthelot, D; Bischoff, FP; De Cleyn, MA; Gijsen, HJ; Jaroskova, L; Macdonald, G; Mercken, M; Oehlrich, D; Rombouts, FJ; Surkyn, M; Trabanco, AA; Tresadern, G; Van Brandt, S; Velter, AI; Wu, T | 1 |
| Chen, Y; Gao, D; Jiang, Y; Jin, F; Liu, F; Tan, C; Wu, Q | 1 |
| Chen, JW; Chen, L; Hou, K; Shen, H; Wu, W; Zhai, JY | 1 |
| Cravatt, BF; Hsu, KL; Inloes, J; Pugh, H; Speers, AE; Tsuboi, K; Whitby, LR | 1 |
| Chang, JW; Cravatt, BF; Hsu, KL; Pugh, H; Speers, AE; Tsuboi, K; Whitby, LR | 1 |
| Anthony, NG; Baek, DJ; Bittman, R; Mackay, SP; MacRitchie, N; Pyne, NJ; Pyne, S | 1 |
| Hoyer, D; Jacobson, LH | 1 |
| Fujita, H; Hayashi, H; Kikuchi, N; Komatsu, K; Komatsu, T; Murayama, H; Narita, T; Ohshiro, H; Sato, S; Taniai, H; Yamada, Y | 1 |
| Hibino, H; Miki, Y; Nishiuchi, Y | 1 |
| Goto, C; Mizui, T; Ohta, H; Tachi, T; Teramachi, H; Toyoshima, M; Tsuchiya, T | 1 |
| Tibaldi, JM | 1 |
| Fraser, K | 1 |
| Athyros, VG; Elisaf, MS; Filippatos, TD | 1 |
| Arias-Montaño, JA; Escamilla-Sánchez, J; González-Pantoja, R; Márquez-Gómez, R; Morales-Figueroa, GE | 1 |
| Dong, G; Gu, J; Jiang, Y; Jiang, Z; Liu, N; Liu, Y; Miao, Z; Sheng, C; Wang, C; Wang, S; Wang, Y; Yao, J; Zhang, W | 1 |
| Ebi, H; Kita, K; Matsumoto, K; Nanjo, S; Takeuchi, S; Tanimoto, A; Yamada, T; Yano, S | 1 |
| Ceribelli, M; Ferrer, M; Guha, R; Joshi, S; Keller, JM; Kelly, PN; Liu, D; Mathews Griner, LA; Nerle, S; Normant, E; Patel, PR; Sandy, P; Shaffer, AL; Shinn, P; Staudt, LM; Thomas, CJ; Wright, GW; Xiao, W; Yang, Y | 1 |
| Coleman, PJ; Fox, SV; Garson, SL; Gotter, AL; Kuduk, SD; McDonald, T; Munden, RL; Renger, JJ; Stevens, J; Tannenbaum, PL; Tye, SJ; Uslaner, JM; Winrow, CJ; Yao, L | 1 |
| Kitagawa, Y; Suzuki, Y; Takayanagi, R; Tokuoka, K; Watanabe, M; Yamada, Y | 1 |
| Downey, P; Michel, A; Nicolas, JM; Scheller, D | 1 |
| Angelini, A; Burg, JS; Dror, RO; Dukkipati, A; Feinberg, EN; Garcia, KC; Ingram, JR; Jude, KM; Ploegh, HL; Venkatakrishnan, AJ; Waghray, D | 1 |
| Beckwith, KA; Byrd, JC; Guinn, D; Hing, ZA; Johnson, AJ; Lapalombella, R; Lehman, AM; Mantel, R; Smith, LL; Williams, E; Williams, K; Woyach, JA | 1 |
| Brunner, J; Bruno, JG; Cabalu, TD; Coleman, PJ; DiMarco, CN; Garson, SL; Gotter, AL; Harrell, CM; Kuduk, SD; O'Brien, JA; Pausch, MH; Renger, JJ; Savitz, AT; Skudlarek, JW; Stevens, J; Tannenbaum, PL; Winrow, CJ | 1 |
| Ali, A; Anand, R; Culberson, C; Deng, Q; Greene, S; Kim, JH; Levorse, D; Lim, YH; Mullins, D; Parker, EM; Sherborne, B; Stamford, A; Tempest, P; Yu, Y; Zhang, X; Zheng, J; Zhou, W | 1 |
| Bhalla, KN; Bradner, JE; Coarfa, C; Devaraj, SG; Fiskus, W; Krieger, S; Li, L; Qi, J; Rajapakshe, K; Saenz, DT; Shah, B; Sharma, S; Sun, B; Wang, ML; Zhang, L | 1 |
| Degterev, A; Geraldo, V; Luther, E; Sriraman, SK; Torchilin, V | 1 |
| Bhamidipati, RK; Gilibili, RR; Mullangi, R; Srinivas, NR | 1 |
| Ding, L; Li, N; Shu, R; Wang, G; Wang, H; Wang, Z; Yu, Y; Zhang, L | 1 |
| Biesmans, I; Cid, JM; Doornbos, ML; Heitman, LH; IJzerman, AP; Lavreysen, H; Mulder-Krieger, T; Pérez-Benito, L; Trabanco, AA; Tresadern, G | 1 |
| Coleman, PJ; Fox, SV; Gotter, AL; Hargreaves, R; Kuduk, SD; Renger, JJ; Savitz, AT; Stevens, J; Tannenbaum, PL; Tye, SJ; Uslaner, JM; Winrow, CJ | 1 |
| Kantevari, S; Pulipati, L; Sriram, D; Yogeeswari, P | 1 |
| Basler, C; Benner, C; Bouvier, N; Bukreyev, A; Campisi, L; Chen, X; Edwards, M; Fenouil, R; García-Sastre, A; Heinz, S; Ho, JSY; Jin, J; Jordan, S; Lagda, AC; Marazzi, I; Martinez-Gil, L; Merad, M; Metreveli, G; Munoz-Fontela, C; Peralta, Z; Pietzsch, C; Rialdi, A; van Bakel, H; Weirauch, M; Zhao, N | 1 |
| Aragão-Leoneti, V; Carvalho, I; Field, RA; Mantoani, SP; Nepogodiev, SA; Rugen, MD; Zamoner, LO | 1 |
| Akhtar, S; Desai, A; Goldwater, R; Han, D; Howieson, C; Kowalski, D; Lademacher, C; Pearlman, H; Rammelsberg, D; Townsend, R; Yamazaki, T | 1 |
| Bogman, K; Bordogna, W; Cleary, Y; Dall, G; De Petris, L; Guerini, E; Martin-Facklam, M; Morcos, PN; Phipps, A; Viteri, S; Yu, L | 1 |
| Iwata, S; Kubo, S; Nakayamada, S; Tanaka, Y | 1 |
| Ben Haj Salah, K; Biagini, G; Bresciani, E; Fehrentz, JA; Liantonio, A; Locatelli, V; Martinez, J; Molteni, L; Omeljaniuk, RJ; Ravelli, M; Rizzi, L; Torsello, A | 1 |
| Gillen, M; Kerr, B; Lee, C; Shen, Z; Valdez, S; Wilson, D; Yang, C | 1 |
| Coleman, PJ; Fox, SV; Gotter, AL; Hodgson, R; Ramirez, AD; Renger, JJ; Roecker, AJ; Smith, SM; Uslaner, JM; Winrow, CJ; Yao, L | 1 |
| Finn, LA; Hussar, DA | 1 |
| Cordomí, A; Doornbos, MLJ; Lavreysen, H; Pardo, L; Peeters, L; Pérez-Benito, L; Tresadern, G | 1 |
| Ahnaou, A; Cid, JM; Doornbos, MLJ; Drinkenburg, WH; Haubrich, J; Heitman, LH; IJzerman, AP; Lavreysen, H; Mulder-Krieger, T; Nunes, A; Trabanco, AA; Tresadern, G; van de Sande, JW; Vermond, SC | 1 |
| D'Haens, GR; De Vries, LCS; Hicks, KJ; Ludbrook, VJ | 1 |
| Boland, BS; Vermeire, S | 1 |
| Belardinelli, L; El-Bizri, N; Li, CH; Liu, GX; Rajamani, S | 1 |
| Camerino, GM; Cantatore, P; Conte, E; Cormio, A; Fehrentz, JA; Fonzino, A; Fracasso, F; Lezza, AMS; Liantonio, A; Martinez, J; Musicco, C; Pesce, V; Rizzi, L; Sirago, G; Torsello, A | 1 |
| Baum, A; Beck, J; Engelhardt, H; Gerlach, D; Gerstberger, T; Hofmann, MH; Kaya, O; Kraut, N; Popow, J; Savarese, F; Scharn, D; Schweifer, N; Tontsch-Grunt, U; Zuber, J | 1 |
| Cheng, MP; Cummins, KC; Davids, MS; Issa, NC; Kubiak, DW; Marty, FM | 1 |
| Bernal-Chico, A; Brown, JM; Cipriani, R; Cravatt, BF; Hsu, KL; Manterola, A; Mato, S; Matute, C; Moreno-Rodríguez, M; Pérez-Samartín, A; Rodríguez-Puertas, R; Ruiz, A | 1 |
| Fu, J; Sun, S | 1 |
| Davies, JS; Duskova, K; Elabi, OF; Lane, EL | 1 |
| Kadri, S; Landesman, Y; Lee, J; Lu, P; Maltsev, N; Ming, M; Shacham, S; Sharma, S; Sukhanova, M; Wang, W; Wang, YL; Wu, W; Xie, B | 1 |
| Arribas, AJ; Bertoni, F; Cascione, L; Curti, E; Gaudio, E; Priebe, V; Rossi, D; Spriano, F; Stathis, A; Tarantelli, C; Zhang, L; Zucca, E | 1 |
| Westhovens, R | 1 |
| Choi, CM; Choi, YJ; Hong, JY; Kim, DH; Lee, JC; Rho, JK; Suh, C; Yoon, DH | 1 |
| Ben Haj Salah, K; Buckinx, A; Cottone, E; De Bundel, D; Fehrentz, JA; Kooijman, R; Pierre, A; Smolders, I; Van Den Herrewegen, Y | 1 |
| Brocato, RL; Hooper, JW | 1 |
| Battat, R; Dulai, PS; Feagan, BG; Jairath, V; Ma, C; Parker, CE; Sandborn, WJ | 1 |
| Gamble, MC; Katsuki, F; McCoy, JG; McKenna, JT; Strecker, RE | 2 |
| Rogler, G | 1 |
| Lee, YH; Song, GG | 3 |
| Dowty, ME; Hegen, M; Jesson, MI; Katkade, V; Lin, TH; Martin, DA; Menon, S; Telliez, JB | 1 |
| Abrantes, JL; Alves, CM; Cunha, AC; de Freitas, CS; de Melo, GR; Ferreira, VF; Fintelman-Rodrigues, N; Jordão, AK; Marttorelli, A; Sacramento, CQ; Souza, TML | 1 |
| Bonovas, S; Danese, S; Lasa, JS; Olivera, PA; Peyrin-Biroulet, L | 1 |
| Bennis, Y; Boone, M; Chouaki, T; Delette, C; Joseph, C; Mabille, C; Maizel, J; Marolleau, JP; Nyga, R | 1 |
| Abbasi, MA; Chohan, TA; Iqbal, J; Khalid, H; Laulloo, SJ; Rasool, S; Rehman, A; Shah, SAA; Siddiqui, SZ | 1 |
| Lefevre, PLC; Vande Casteele, N | 1 |
| Georgiou, S; Plachouri, KM | 1 |
| Abd Eldaim, MA; Abdallah, AEM; Abdel-Daim, MM; Abdelaziz, SAM; Abdul Rashid, S; Abdullah, AS; Abdullah, LC; Abramson, MJ; Ahmed, HB; Ahmed, MM; Ahn, YC; Alexander, DC; Ando, T; Angelone, AM; Anglani, F; Ap, Y; Arthanari, SK; Axelrad, C; Bai, S; Bakonyi, P; Barnes, E; Beckmann, NA; Bélafi-Bakó, K; Bennett, CM; Bestha, RM; Bitsch, RG; Bradley, CA; Bu, Y; Calò, LA; Cañedo-Villaroya, E; Carlson, L; Caruso, S; Casado-Flores, J; Ceol, M; Cesarino, I; Chen, IL; Chen, R; Chen, X; Chilvers, MI; Cho, WK; Choong, TSY; Conceição-Neto, N; Culver, EL; Dai, X; de Lama Caro-Patón, G; De Rosa, I; Del Prete, D; Dharmage, SC; Dimitriadis, E; Dittakavi, S; Dobrowolski, JC; Edin, S; Elgarawany, GE; Emam, HE; Emmens, RW; Erbas, B; Erwich, JJHM; Farghali, M; Feng, L; Funston, RN; Gabler, NK; Gale, P; Ganesh, M; Gao, J; Gao, L; Gao, X; García-Salido, A; Gatto, R; Gautam, S; Ge, C; Ghogomu, SM; Gianesello, L; Gonçales, VR; Gooch, JL; Gooding, JJ; Gourley, GG; Gu, H; Gu, X; Gu, Z; Guerreri, M; Guillén, M; Hazzaa, SM; Heylen, E; Hicks, R; Hong, X; Hoshi, M; Hu, B; Hu, LX; Hu, R; Hu, S; Huang, J; Huang, K; Hubbard, WB; Hui, J; Hwang, NY; Iannacci, J; Ianus, A; Iglesias-Bouzas, MI; Ihara, I; Iwasaki, M; Jaeger, S; Kandel, YR; Karpińska, G; Kim, HK; Klopfenstein, TJ; Knorr, D; Koók, L; Kotb, S; Kruithof, S; Larsson, P; Laurence, C; Leng, J; Li, H; Li, J; Li, Q; Li, S; Li, X; Li, Z; Lian, J; Liang, JX; Liang, X; Lighaam, LC; Lin, CW; Lin, HC; Lin, J; Ling, A; Liu, J; Liu, P; Liu, YS; Ljuslinder, I; Lo, GH; Lodge, CJ; Löfgren-Burström, A; Lowe, AJ; Lu, M; Lu, N; Lucero-Prisno, DE; Luebbe, KM; Luo, X; Ma, Z; Maes, P; Makuch, M; Malekbala, MR; Mao, Z; Martínez-Romera, I; Marzo, G; Mathew, FM; Mattei, A; Matthijnssens, J; Mayumi, M; Morita, N; Mueller, DS; Mullangi, R; Mummolo, S; Murthi, P; Myte, R; Nabeshima, T; Nakamoto, K; Nehdi, IA; Nemestóthy, N; Niessen, HWM; Noh, JM; Nota, A; Nunes, D; Oh, D; Öhlund, D; Olsen, KM; Ono, H; Osawa, Y; Palmqvist, R; Palombo, M; Park, M; Patience, JF; Peng, Y; Perng, DS; Persano, A; Priante, G; Prince, SJ; Pulipati, S; Pyo, H; Qiu, X; Quan, J; Quaranta, F; Quinzi, V; Rademacher, CJ; Rajaraman, G; Rashid, U; Rauch, JC; Rector, A; Remmerswaal, EBM; Ren, R; Rispens, T; Rocha, GS; Saad, NM; Saito, K; Salamova, A; Sarfaraz, K; Satoshi, A; Schnellmann, RG; Scholpa, NE; Schonhoff, M; Schwartz, KJ; Schwarze, M; Schweer, WP; Seiichi, Y; Serrano-González, A; Severino, J; Shemesh, N; Shi, ZQ; Shike, DW; Shim, YM; Siciliano, PA; Siebenrock, KA; Silva, MKL; Smith, DL; Soltani, S; Song, YM; Spry, ML; Stalker, LA; Stokes, RS; Sullivan, PG; Sun, JM; Sun, S; Svanes, C; Syo, K; Tai, CM; Takashima, S; Tashita, C; Taurino, A; Ten Berge, IJM; Tenuta, AU; Teo, SH; Tilley, RD; Trivedi, RK; Umetsu, K; Unger, PA; van Bruggen, R; van Ham, SM; Van Ranst, M; Vanitha, J; Vekaria, HJ; Venier, M; Venkateshwaran, K; Venkert, A; Vermeulen, E; Wan, C; Wang, H; Wang, N; Wang, P; Wang, T; Wang, X; Wang, Y; Wise, KA; Wolbink, GJ; Wu, J; Wu, P; Wu, S; Wu, Y; Xia, Q; Xin, W; Xiong, Q; Xu, H; Xu, P; Xue, S; Yamamoto, Y; Yamashiro, T; Yan, F; Yan, H; Yan, S; Yan, Y; Yang, JM; Yang, L; Yang, P; Ye, W; Yeh, JH; Yinda, CK; Ying, GG; Ying, L; Yoon, HG; Yu, H; Zainuddin, M; Zakkula, A; Zeller, M; Zeng, Y; Zha, J; Zhang, F; Zhang, H; Zhang, M; Zhang, Q; Zhang, S; Zhang, T; Zhang, Z; Zhao, C; Zhao, J; Zhao, Y; Zhong, Q; Zhu, J; Zingmark, C; Zo, JI; Zou, Y | 1 |
| Gyu Song, G; Ho Lee, Y | 1 |
| Argollo, M; Dal Buono, A; Danese, S; Roda, G | 1 |
| Allocca, M; Correale, C; Danese, S; Fiorino, G; Furfaro, F; Gabbiadini, R; Gilardi, D; Peyrin-Biroulet, L; Zilli, A | 1 |
| Adderley, T; Christopher, G; Irwin, MS; Kano, Y; Kee, L; Ladumor, Y; Ohh, M; Robinson, CM; Valencia-Sama, I | 1 |
| Abrisqueta, P; Bobillo, S; Boix, J; Bosch, F; Carabia, J; Castellví, J; Céspedes Torrez, DH; Crespo, M; Escoda, L; Jiménez, I; Martínez-Ricarte, F; Nieto, JC; Pagès, C; Palacio, C; Perla, C; Puigdefàbregas, L; Purroy, N; Seoane, J | 1 |
| Earl, DC; Van Tyle, KM | 1 |
| Lee, YH; Sung, YK | 1 |
| Aletaha, D; Baraliakos, X; Boehncke, WH; de Wit, M; Dörner, T; Dougados, M; Emery, P; Fleischmann, RM; Geissler, K; Isaacs, JD; Kerschbaumer, A; Kremer, J; Lee, EB; Maksymowych, WP; McInnes, I; Nash, P; Pope, JE; Smolen, JS; Stoffer-Marx, M; Takeuchi, T; Tam, LS; Tanaka, Y; Trauner, M; van den Bosch, F; van der Heijde, D; Voshaar, M; Westhovens, R; Winthrop, KL; Xavier, R | 1 |
| Adamopoulos, IE; Davis, J; Doyran, B; Fukui, T; Han, L; Haudenschild, AK; Haudenschild, DR; Yik, JHN | 1 |
| Adas, M; Bechman, K; Cope, AP; Galloway, JB; Mootoo, A; Norton, S; Patel, V; Qureshi, S; Rampes, S; Yates, M | 1 |
| Amador-Sánchez, YA; Cruz-Mendoza, MA; Hernández-Vázquez, E; Miranda, LD; Ramírez-Apán, MT | 1 |
| Amundsen, S; Fuskevåg, OM; Nordeng, H; Nordmo, E; Sager, G; Spigset, O | 1 |
| Campigotto, F; Di Paolo, JA; Galien, R; Meng, A; Murray, B; Traves, PG | 1 |
| Bennett, JM; Chen, Z; Cook, DN; Gopinatth, V; Jacobson, KA; Jung, YH; Karcz, TP; Lieberman, DI; Phung, NB; Randle, JCR; Salmaso, V; Salvemini, D; Wen, Z | 1 |
| Chang, Y; Chen, J; Christiano, AM; Dai, Z | 1 |
| Cummings, JRF; Harris, C | 1 |
| Abi-Gerges, N; Cotta, T; Espinoza, A; Geft, V; Ghetti, A; Hernandez, E; Indersmitten, T; Macias, A; Mai, C; Miller, PE; Miron, Y; Nguyen, W; Page, G; Rasoul, L; Stafford, A; Sweat, K; Ton, AT; Truong, K; Wong, T | 1 |
| Ajmera, V; Gores, GJ; Grimmer, K; Gutierrez, JA; Harrison, SA; Kemble, G; Loomba, R; Lucas, KJ; McCulloch, W; Mohseni, R; Neuschwander-Tetri, BA; O'Farrell, M; Perry, RG; Rahimi, RS; Ratziu, V; Rinella, M; Trotter, JF; Wai-Sun Wong, V; Wayne, JD | 1 |
| Aparna, P; Bhavani, AKD; Gautier, F; Grée, R; Juin, P; Le Guevel, R; Levoin, N; Mosset, P; Murthy, AVR; Narendar, V; Reddy, CR; Roul, J; Sampath Kumar, N; Solhi, H | 1 |
| Kim, JW; Kim, SY | 1 |
| Baker, S; Bhat, S; Byrd, JC; Canfield, D; Cempre, CB; Fu, Q; Hu, B; Huang, Y; Jaglowski, SM; Lapalombella, R; Lockman, H; Rogers, KA; Ruppert, AS; Shah, H; Stephens, DM; Vadeboncoeur, R; Walker, JS; Woyach, JA | 1 |
| Eisner, JR; Lerner, LM; Michmerhuizen, AR; Pesch, AM; Pierce, LJ; Rae, JM; Schwartz, R; Speers, CW; Ward, C; Wilder-Romans, K; Zhang, A | 1 |
| Bhattacharya, D; Buckley, D; Crowley, R; Duke, G; Friedman, SL; Kemble, G; Martins, EB; O'Farrell, M | 1 |
59 review(s) available for triazoles and piperidines
| Article | Year |
|---|---|
From ginkgolides to N-substituted piperidino-thieno diazepines, a new series of highly potent dual antagonists.
Topics: Animals; Azepines; Diterpenes; Ginkgolides; Humans; Lactones; Piperidines; Plant Extracts; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles | 1991 |
The potential benefits of serotonin receptor-specific agents.
Topics: Antidepressive Agents; Buspirone; Depressive Disorder; Humans; Isoxazoles; Ondansetron; Piperazines; Piperidines; Receptors, Serotonin; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin; Sumatriptan; Triazoles | 1994 |
Profiles of 5-HT 1B/1D agonists in acute migraine with special reference to second generation agents.
Topics: Acute Disease; Animals; Clinical Trials as Topic; Coronary Circulation; Coronary Vasospasm; Drug Design; Drug Interactions; Humans; Inactivation, Metabolic; Indoles; Meninges; Migraine Disorders; Molecular Structure; Nociceptors; Oxazoles; Oxazolidinones; Piperidines; Propranolol; Pyrrolidines; Randomized Controlled Trials as Topic; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Recurrence; Serotonin Receptor Agonists; Structure-Activity Relationship; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines; Vasoconstrictor Agents | 1999 |
The scientific basis of medication choice in symptomatic migraine treatment.
Topics: Acute Disease; Choice Behavior; Dose-Response Relationship, Drug; Humans; Indoles; Migraine Disorders; Models, Biological; Oxazoles; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Severity of Illness Index; Sumatriptan; Triazoles; Tryptamines | 1999 |
Newer intranasal migraine medications.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Non-Narcotic; Clinical Trials as Topic; Dihydroergotamine; Half-Life; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Recurrence; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines | 2000 |
Current and emerging second-generation triptans in acute migraine therapy: a comparative review.
Topics: Acute Disease; Carbazoles; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Triazoles; Tryptamines | 2000 |
New abortive agents for the treatment of migraine.
Topics: Clinical Trials as Topic; Female; Humans; Indoles; Male; Migraine Disorders; Oxazolidinones; Piperidines; Prognosis; Recurrence; Serotonin Receptor Agonists; Severity of Illness Index; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines | 2001 |
[Current topics: expectation for new triptans].
Topics: Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines | 2001 |
Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans).
Topics: Analgesics, Non-Narcotic; Carbazoles; Clinical Trials as Topic; Humans; Indoles; Migraine Disorders; Oxazolidinones; Pain Measurement; Patient Satisfaction; Piperidines; Pyrrolidines; Serotonin Receptor Agonists; Sumatriptan; Time Factors; Treatment Outcome; Triazoles; Tryptamines | 2001 |
Comparison of rizatriptan and other triptans on stringent measures of efficacy.
Topics: Administration, Oral; Humans; Indoles; Migraine Disorders; Oxazolidinones; Patient Satisfaction; Piperidines; Randomized Controlled Trials as Topic; Retrospective Studies; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines | 2001 |
Acute treatment of migraine and the role of triptans.
Topics: Acute Disease; Blood Flow Velocity; Carbazoles; Clinical Trials as Topic; Drug Administration Routes; Female; Humans; Indoles; Male; Menstruation; Migraine Disorders; Oxazolidinones; Piperidines; Practice Guidelines as Topic; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines; Vasoconstriction; Vasoconstrictor Agents | 2001 |
Mechanisms of action of the 5-HT1B/1D receptor agonists.
Topics: Carbazoles; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines | 2002 |
Comparative aspects of triptans in treating migraine.
Topics: Carbazoles; Cardiovascular Diseases; Humans; Indoles; Migraine Disorders; Oxazolidinones; Patient Satisfaction; Piperidines; Pyrrolidines; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines | 2001 |
Naratriptan for the treatment of acute migraine: meta-analysis of randomised controlled trials.
Topics: Dose-Response Relationship, Drug; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Randomized Controlled Trials as Topic; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines | 2004 |
[Recent progress in therapy for migraine headache].
Topics: Anticonvulsants; Botulinum Toxins; Calcitonin Gene-Related Peptide; Central Nervous System; Clinical Trials as Topic; Drug Design; Fructose; Humans; Indoles; Meta-Analysis as Topic; Migraine Disorders; Pain; Piperidines; Pyrrolidines; Serotonin Receptor Agonists; Signal Transduction; Sumatriptan; Topiramate; Triazoles; Trigeminal Nerve; Tryptamines; Vasodilation | 2004 |
[Meta-analysis of triptan treatment in migraine].
Topics: Carbazoles; Evidence-Based Medicine; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1D; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines | 2004 |
Migraine headache.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Diclofenac; Drug Therapy, Combination; Ergotamine; Humans; Ibuprofen; Indoles; Migraine Disorders; Naproxen; ortho-Aminobenzoates; Oxazolidinones; Piperidines; Pyrrolidines; Salicylates; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines | 2003 |
Migraine headache.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ergotamine; Humans; Ibuprofen; Indoles; Migraine Disorders; Naproxen; ortho-Aminobenzoates; Oxazolidinones; Piperidines; Pyrrolidines; Salicylates; Sumatriptan; Triazoles; Tryptamines | 2004 |
[New concepts in the treatment of type 2 diabetes].
Topics: Adamantane; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Liraglutide; Nitriles; Peptides; Piperidines; Pyrazines; Pyrazoles; Pyrrolidines; Rimonabant; Sitagliptin Phosphate; Triazoles; Venoms; Vildagliptin | 2007 |
Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats.
Topics: Animals; Anorexia; Anti-Obesity Agents; Biological Availability; Brain; Cannabinoids; Central Nervous System; Drug Synergism; Eating; Endocannabinoids; Energy Metabolism; Feeding Behavior; Obesity; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Rimonabant; Triazoles | 2008 |
Drugs for type 2 diabetes.
Topics: alpha-Galactosidase; Biguanides; Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Combinations; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Nateglinide; Phenylalanine; Piperidines; Pyrazines; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiazolidinediones; Triazoles | 2008 |
DPP4 inhibitors: from sitagliptin monotherapy to the new alogliptin-pioglitazone combination therapy.
Topics: Adamantane; Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Pioglitazone; Piperidines; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Triazoles; Uracil | 2009 |
The physiologic role of incretin hormones: clinical applications.
Topics: Adamantane; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Progression; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Incretins; Piperidines; Pyrazines; Sitagliptin Phosphate; Triazoles; Uracil | 2010 |
Managing type 2 diabetes in the primary care setting: beyond glucocentricity.
Topics: Adamantane; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Hypoglycemic Agents; Liraglutide; Nitriles; Obesity; Patient Compliance; Peptides; Piperidines; Precision Medicine; Primary Health Care; Pyrazines; Pyrrolidines; Risk Factors; Sitagliptin Phosphate; Triazoles; Uracil; Venoms; Vildagliptin | 2010 |
Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions.
Topics: Adamantane; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Humans; Linagliptin; Nitriles; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Sitagliptin Phosphate; Triazoles; Uracil; Vildagliptin | 2010 |
DPP-4 inhibitors: what may be the clinical differentiators?
Topics: Adamantane; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Energy Intake; Gastric Emptying; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Incretins; Intestinal Mucosa; Linagliptin; Neurons; Nitriles; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Sitagliptin Phosphate; Triazoles; Uracil; Vildagliptin | 2010 |
Preventive therapy for breast cancer: a consensus statement.
Topics: Anastrozole; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Consensus Development Conferences as Topic; Diphosphonates; Estrogen Receptor Modulators; Expert Testimony; Female; Fenretinide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Nitriles; Norpregnenes; Piperidines; Premenopause; Pyrrolidines; Raloxifene Hydrochloride; Retinoids; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Triazoles | 2011 |
Incretin therapies in the management of elderly patients with type 2 diabetes mellitus.
Topics: Adamantane; Age Factors; Aged; Aging; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Linagliptin; Liraglutide; Male; Middle Aged; Nitriles; Peptides; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Uracil; Venoms; Vildagliptin | 2011 |
Quantitative model of the relationship between dipeptidyl peptidase-4 (DPP-4) inhibition and response: meta-analysis of alogliptin, saxagliptin, sitagliptin, and vildagliptin efficacy results.
Topics: Adamantane; Biomarkers; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Models, Biological; Nitriles; Piperidines; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Uracil; Vildagliptin | 2012 |
DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials.
Topics: Adamantane; Clinical Trials as Topic; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Linagliptin; Male; Metformin; Nitriles; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Sitagliptin Phosphate; Triazoles; Uracil; Vildagliptin; Weight Gain | 2012 |
An update in incretin-based therapy: a focus on dipeptidyl peptidase--4 inhibitors.
Topics: Adamantane; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Female; Glucagon-Like Peptide 1; Humans; Linagliptin; Male; Nitriles; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Uracil; Vildagliptin | 2012 |
Noninsulin glucose-lowering agents for the treatment of patients on dialysis.
Topics: Adamantane; Biguanides; Diabetic Nephropathies; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Progression; Glucagon-Like Peptides; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Linagliptin; Meglumine; Metformin; Nitriles; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Renal Dialysis; Renal Insufficiency, Chronic; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiazolidinediones; Treatment Outcome; Triazoles; Uracil; Vildagliptin | 2013 |
Combination therapy with DPP-4 inhibitors and insulin in patients with type 2 diabetes mellitus: what is the evidence?
Topics: Adamantane; Body Weight; Diabetes Complications; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Progression; Drug Therapy, Combination; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Linagliptin; Nitriles; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Renal Insufficiency, Chronic; Sitagliptin Phosphate; Triazoles; Uracil; Vildagliptin | 2013 |
Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.
Topics: Acetamides; Animals; Azepines; Benzofurans; Humans; Isoquinolines; Models, Biological; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrimidines; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles; Wakefulness | 2014 |
Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?
Topics: Acetamides; Animals; Azepines; Behavior, Addictive; Benzofurans; Feeding Behavior; Humans; Intracellular Signaling Peptides and Proteins; Isoquinolines; Mice; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Piperidines; Pyrimidines; Rats; Reward; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles | 2013 |
Incorporating incretin-based therapies into clinical practice for patients with type 2 diabetes.
Topics: Adamantane; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Linagliptin; Liraglutide; Peptides; Piperidines; Purines; Pyrazines; Quinazolines; Receptors, Glucagon; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Uracil; Venoms; Weight Loss | 2014 |
The pharmacokinetic considerations and adverse effects of DPP-4 inhibitors [corrected].
Topics: Adamantane; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Humans; Linagliptin; Nitriles; Piperidines; Piperidones; Purines; Pyrazines; Pyrazoles; Pyrimidines; Pyrrolidines; Quinazolines; Sitagliptin Phosphate; Thiazolidines; Triazoles; Uracil; Vildagliptin | 2014 |
Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinases; Molecular Targeted Therapy; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Triazoles | 2016 |
Janus Kinase Antagonists and Other Novel Small Molecules for the Treatment of Crohn's Disease.
Topics: B-Lymphocytes; Colitis, Ulcerative; Crohn Disease; Humans; Indans; Janus Kinase 1; Janus Kinase Inhibitors; Oligonucleotides; Oxadiazoles; Piperidines; Pyridines; Pyrimidines; Pyrroles; Receptors, Lysosphingolipid; Smad7 Protein; T-Lymphocytes; Triazoles | 2017 |
Methyl-containing pharmaceuticals: Methylation in drug design.
Topics: Animals; Azepines; Dogs; Drug Design; Humans; Methylation; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Pharmacology; Piperidines; Pyrimidines; Rats; Solubility; Triazoles | 2018 |
Clinical efficacy of new JAK inhibitors under development. Just more of the same?
Topics: Adamantane; Arthritis, Rheumatoid; Azetidines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase 1; Janus Kinase 3; Janus Kinase Inhibitors; Niacinamide; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome; Triazoles; Valine | 2019 |
Progress on the Prevention and Treatment of Hantavirus Disease.
Topics: Adrenal Cortex Hormones; Amides; Animals; Antiviral Agents; Clinical Trials as Topic; Hantavirus Infections; Hantavirus Pulmonary Syndrome; Hemorrhagic Fever with Renal Syndrome; Humans; Immunotherapy; Lactoferrin; Models, Animal; Nucleosides; Orthohantavirus; Piperidines; Pyrazines; Quinazolines; Recombinant Proteins; Ribavirin; Triazoles; Vaccines, Synthetic; Viral Vaccines | 2019 |
Innovations in Oral Therapies for Inflammatory Bowel Disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Discovery; Heterocyclic Compounds, 3-Ring; Humans; Indans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Mesalamine; Oxadiazoles; Phosphodiesterase Inhibitors; Piperidines; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Receptors, Lysosphingolipid; Triazoles | 2019 |
Efficacy of JAK inhibitors in Crohn's Disease.
Topics: Crohn Disease; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Piperidines; Pyridines; Pyrimidines; Treatment Failure; Treatment Outcome; Triazoles | 2020 |
Comparison of the efficacy and safety of tofacitinib and filgotinib in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Piperidines; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles | 2020 |
Safety of Janus Kinase Inhibitors in Patients With Inflammatory Bowel Diseases or Other Immune-mediated Diseases: A Systematic Review and Meta-Analysis.
Topics: Arthritis, Rheumatoid; Azetidines; Herpes Zoster; Heterocyclic Compounds, 3-Ring; Humans; Incidence; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Janus Kinases; Piperidines; Placebos; Psoriasis; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Spondylitis, Ankylosing; Sulfonamides; Survival Analysis; Treatment Outcome; Triazoles | 2020 |
Clinical Pharmacology of Janus Kinase Inhibitors in Inflammatory Bowel Disease.
Topics: Heterocyclic Compounds, 3-Ring; Humans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Piperidines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Triazoles | 2020 |
JAK inhibitors in chronic plaque psoriasis: What is known so far.
Topics: Adamantane; Azetidines; Humans; Janus Kinase Inhibitors; Janus Kinases; Niacinamide; Nitriles; Piperidines; Prospective Studies; Psoriasis; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Triazoles | 2020 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Amylose; Anaerobiosis; Animals; Anti-Bacterial Agents; Anura; Arginase; Arthritis, Rheumatoid; Asthma; Atmosphere; B-Lymphocytes; Basic Helix-Loop-Helix Transcription Factors; Bioelectric Energy Sources; Biofilms; Biofuels; Biomarkers; Biopolymers; Bioreactors; Brain; Brain Injuries, Traumatic; Breast Neoplasms; Calibration; Carbon Tetrachloride; Caspase 3; Catalysis; Catechin; Cations; Cattle; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Body; Cell Line, Tumor; Cell Plasticity; Chemical and Drug Induced Liver Injury; Chemistry Techniques, Synthetic; China; Chitosan; Chloride Channels; Chromatography, High Pressure Liquid; Chromosome Mapping; Cognition; Cognitive Dysfunction; Cohort Studies; Colitis, Ulcerative; Colloids; Coloring Agents; Congresses as Topic; Correlation of Data; Crystallization; Cyanoacrylates; Cyclohexane Monoterpenes; Cyprinidae; Cytochrome P-450 CYP1A1; Death, Sudden; Dent Disease; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Disease Progression; Disease Resistance; Disulfides; Drug Monitoring; Drug Stability; Ecotoxicology; Electricity; Electrodes; Endocytosis; Environmental Exposure; Environmental Monitoring; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Esophageal and Gastric Varices; Esters; Fagopyrum; Female; Ferrosoferric Oxide; Flame Retardants; Flavobacteriaceae; Flow Cytometry; Follow-Up Studies; Formoterol Fumarate; Fusarium; Garlic; Gastrointestinal Hemorrhage; Gene Expression; Genes, Plant; Genetic Markers; Glial Fibrillary Acidic Protein; Gliosis; Global Health; Glutathione Transferase; Glycine max; Gum Arabic; Hemostasis, Endoscopic; Hepatocytes; Hippocampus; Humans; Hydrogen-Ion Concentration; Illinois; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant, Newborn; Infant, Small for Gestational Age; Injections, Intraperitoneal; Interleukin-4; Iowa; Iron; Ki-67 Antigen; Kidney; Kinetics; Kynurenine; Lakes; Levofloxacin; Lipid Peroxidation; Lipids; Liver; Liver Cirrhosis, Experimental; Magnetic Fields; Magnetic Iron Oxide Nanoparticles; Male; Manure; Maze Learning; Memory, Short-Term; Metal Nanoparticles; Metals, Heavy; Methane; Mice; Mice, Inbred C57BL; Mice, Knockout; Michigan; Microalgae; Microbial Consortia; Mitochondria; Models, Animal; Models, Chemical; Models, Neurological; Molecular Structure; Molecular Weight; Mutation; Myeloid-Derived Suppressor Cells; NADPH Oxidase 2; Neoplasm Recurrence, Local; Neurites; Neurons; Neuroprotective Agents; NF-kappa B; NIH 3T3 Cells; Nitric Oxide Synthase Type II; Nitrogen; Ohio; Ointments; Ontario; Organelle Biogenesis; Organophosphates; Organophosphorus Compounds; Oxidative Stress; Palladium; Particle Size; Pectins; Phenotype; Phytotherapy; Piperidines; Placenta; Plant Diseases; Plant Extracts; Polymers; Polymorphism, Genetic; Polyphenols; Powders; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Protein Kinase Inhibitors; Protein Structure, Secondary; Proteins; Pyridines; Pyrimidines; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Receptors, Chemokine; Receptors, Formyl Peptide; Receptors, Lipoxin; Recovery of Function; Recurrence; Reference Standards; Reference Values; Reproducibility of Results; Respiratory Function Tests; Retrospective Studies; Risk; Sensitivity and Specificity; Sewage; Signal Transduction; Sodium Glutamate; Soil; Solanum tuberosum; Solubility; Solutions; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spermatozoa; STAT3 Transcription Factor; Sulfamethoxazole; Tea; Temperature; Thermodynamics; Thrombin; Treatment Outcome; Triazoles; United States; Viscosity; Waste Disposal, Fluid; Wastewater; Water; Water Pollutants, Chemical; Water Purification; White Matter; Wisconsin; X-Ray Diffraction; Zea mays | 2013 |
Comparative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in active rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Biological Products; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome; Triazoles | 2021 |
Comparative efficacy and safety of tofacitinib, baricitinib, upadacitinib, filgotinib and peficitinib as monotherapy for active rheumatoid arthritis.
Topics: Adamantane; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Bayes Theorem; Heterocyclic Compounds, 3-Ring; Humans; Niacinamide; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Sulfonamides; Triazoles | 2020 |
JAK selectivity: more precision less troubles.
Topics: Colitis, Ulcerative; Crohn Disease; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Janus Kinase Inhibitors; Naphthyridines; Nitriles; Piperidines; Pyridines; Pyrimidines; Signal Transduction; Triazoles; TYK2 Kinase | 2020 |
PK, PD, and interactions: the new scenario with JAK inhibitors and S1P receptor modulators, two classes of small molecule drugs, in IBD.
Topics: Acetates; Animals; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Heterocyclic Compounds, 3-Ring; Humans; Indans; Indoles; Janus Kinase Inhibitors; Oxadiazoles; Piperidines; Pyridines; Pyrimidines; Quinolones; Sphingosine-1-Phosphate Receptors; Triazoles | 2020 |
New pharmacologic agents for insomnia and hypersomnia.
Topics: Azepines; Carbamates; Dementia; Disorders of Excessive Somnolence; GABA-A Receptor Agonists; Humans; Orexin Receptor Antagonists; Phenylalanine; Piperidines; Pyridines; Pyrimidines; Sleep Aids, Pharmaceutical; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders; Trazodone; Triazoles; Zolpidem | 2020 |
Comparative study of the efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib versus methotrexate for disease-modifying antirheumatic drug-naïve patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Bayes Theorem; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Sulfonamides; Treatment Outcome; Triazoles | 2021 |
Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement.
Topics: Adamantane; Advisory Committees; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Azetidines; Cytokines; Drug Therapy, Combination; Europe; Heterocyclic Compounds, 3-Ring; Humans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Niacinamide; Piperidines; Psoriasis; Purines; Pyrazoles; Pyridines; Pyrimidines; Rheumatology; Spondylarthropathies; Spondylitis, Ankylosing; Sulfonamides; Triazoles | 2021 |
Venous Thromboembolism Risk With JAK Inhibitors: A Meta-Analysis.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Azetidines; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Heterocyclic Compounds, 3-Ring; Humans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Piperidines; Psoriasis; Pulmonary Embolism; Purines; Pyrazoles; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Risk; Spondylarthropathies; Spondylitis, Ankylosing; Sulfonamides; Triazoles; Venous Thromboembolism; Venous Thrombosis | 2021 |
JAK1 inhibition and inflammatory bowel disease.
Topics: Heterocyclic Compounds, 3-Ring; Humans; Inflammatory Bowel Diseases; Janus Kinase 1; Janus Kinase Inhibitors; Piperidines; Pyridines; Pyrimidines; Triazoles | 2021 |
The Era of Janus Kinase Inhibitors for Inflammatory Bowel Disease Treatment.
Topics: Adamantane; Colitis; Colitis, Ulcerative; Crohn Disease; Heterocyclic Compounds, 3-Ring; Humans; Inflammatory Bowel Diseases; Janus Kinase Inhibitors; Janus Kinases; Niacinamide; Piperidines; Pyridines; Pyrimidines; Pyrroles; Triazoles | 2021 |
19 trial(s) available for triazoles and piperidines
| Article | Year |
|---|---|
Sufotidine 600 mg bd virtually eliminates 24 hour intragastric acidity in duodenal ulcer subjects.
Topics: Adult; Circadian Rhythm; Double-Blind Method; Duodenal Ulcer; Gastric Acid; Gastrins; Histamine H2 Antagonists; Humans; Male; Middle Aged; Piperidines; Triazoles | 1990 |
Loss of acid suppression during dosing with H2-receptor antagonists.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Electrodes; Gastric Acid; Gastrins; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Piperidines; Ranitidine; Triazoles | 1990 |
Tolerance during 8 days of high-dose H2-blockade: placebo-controlled studies of 24-hour acidity and gastrin.
Topics: Adult; Drug Tolerance; Gastric Acid; Gastrins; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Piperidines; Placebos; Ranitidine; Triazoles | 1990 |
The effects of 15 days of dosing with placebo, sufotidine 600 mg nocte or sufotidine 600 mg twice daily upon 24-hour intragastric acidity and 24-hour plasma gastrin.
Topics: Adult; Double-Blind Method; Gastric Acid; Gastrins; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Piperidines; Triazoles | 1990 |
Inhibition of gastric secretion following single morning or twice daily oral administration of sufotidine to volunteers.
Topics: Administration, Oral; Adult; Double-Blind Method; Esophagitis; Gastric Acid; Gastric Juice; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Pepsin A; Piperidines; Triazoles | 1989 |
Use of clozapine in tardive dystonia.
Topics: Adult; Clozapine; Dystonia; Female; Humans; Male; Middle Aged; Piperidines; Triazoles | 1996 |
Comparison of rizatriptan 10 mg vs. naratriptan 2.5 mg in migraine.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indoles; Male; Middle Aged; Migraine Disorders; Piperidines; Recurrence; Serotonin Receptor Agonists; Treatment Outcome; Triazoles; Tryptamines | 1999 |
Clinical features of withdrawal headache following overuse of triptans and other headache drugs.
Topics: Adult; Analgesics; Drug Therapy, Combination; Ergotamine; Female; Headache; Humans; Indoles; Male; Middle Aged; Oxazolidinones; Piperidines; Prospective Studies; Substance Withdrawal Syndrome; Sumatriptan; Triazoles; Tryptamines; Vasoconstrictor Agents | 2001 |
In vitro evaluation of color change in maxillofacial elastomer through the use of an ultraviolet light absorber and a hindered amine light stabilizer.
Topics: Absorption; Amines; Analysis of Variance; Anthraquinones; Biocompatible Materials; Colorimetry; Decanoic Acids; Humans; Materials Testing; Maxillofacial Prosthesis; Pigments, Biological; Piperidines; Prosthesis Coloring; Silicone Elastomers; Spectrophotometry; Triazoles; Ultraviolet Rays | 2004 |
Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers.
Topics: Adult; Anesthetics, Intravenous; Aryl Hydrocarbon Hydroxylases; Benzoates; Carbamates; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Deferasirox; Drug Interactions; Enzyme Inhibitors; Female; Humans; Hypoglycemic Agents; Iron Chelating Agents; Male; Midazolam; Piperidines; Rifampin; Triazoles | 2010 |
Quantitative model of the relationship between dipeptidyl peptidase-4 (DPP-4) inhibition and response: meta-analysis of alogliptin, saxagliptin, sitagliptin, and vildagliptin efficacy results.
Topics: Adamantane; Biomarkers; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Models, Biological; Nitriles; Piperidines; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Uracil; Vildagliptin | 2012 |
Dipeptidyl peptidase-4 inhibitors attenuate endothelial function as evaluated by flow-mediated vasodilatation in type 2 diabetic patients.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Cholesterol, LDL; Cross-Over Studies; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inositol; Japan; Linear Models; Male; Middle Aged; Piperidines; Prospective Studies; Pyrazines; Regional Blood Flow; Sitagliptin Phosphate; Time Factors; Treatment Outcome; Triazoles; Uracil; Vasodilation | 2013 |
DPP-4 inhibition with alogliptin on top of angiotensin II type 1 receptor blockade ameliorates albuminuria via up-regulation of SDF-1α in type 2 diabetic patients with incipient nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Chemokine CXCL12; Cross-Over Studies; Cyclic AMP; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Female; Humans; Male; Middle Aged; Piperidines; Pyrazines; Receptor, Angiotensin, Type 1; Sitagliptin Phosphate; Triazoles; Up-Regulation; Uracil | 2014 |
Theory-based analysis of clinical efficacy of triptans using receptor occupancy.
Topics: Humans; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Serotonin 5-HT1 Receptor Agonists; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines | 2014 |
Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects.
Topics: Adult; Area Under Curve; Bupropion; Caffeine; Carbamates; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Methadone; Middle Aged; Nitriles; Piperidines; Pyridines; Triazoles; Young Adult | 2017 |
Clinical Drug-Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib.
Topics: Adult; Anaplastic Lymphoma Kinase; Carbazoles; Carcinoma, Non-Small-Cell Lung; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Midazolam; Middle Aged; Piperidines; Receptor Protein-Tyrosine Kinases; Rifampin; Treatment Outcome; Triazoles; Young Adult | 2017 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Amylose; Anaerobiosis; Animals; Anti-Bacterial Agents; Anura; Arginase; Arthritis, Rheumatoid; Asthma; Atmosphere; B-Lymphocytes; Basic Helix-Loop-Helix Transcription Factors; Bioelectric Energy Sources; Biofilms; Biofuels; Biomarkers; Biopolymers; Bioreactors; Brain; Brain Injuries, Traumatic; Breast Neoplasms; Calibration; Carbon Tetrachloride; Caspase 3; Catalysis; Catechin; Cations; Cattle; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Body; Cell Line, Tumor; Cell Plasticity; Chemical and Drug Induced Liver Injury; Chemistry Techniques, Synthetic; China; Chitosan; Chloride Channels; Chromatography, High Pressure Liquid; Chromosome Mapping; Cognition; Cognitive Dysfunction; Cohort Studies; Colitis, Ulcerative; Colloids; Coloring Agents; Congresses as Topic; Correlation of Data; Crystallization; Cyanoacrylates; Cyclohexane Monoterpenes; Cyprinidae; Cytochrome P-450 CYP1A1; Death, Sudden; Dent Disease; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Disease Progression; Disease Resistance; Disulfides; Drug Monitoring; Drug Stability; Ecotoxicology; Electricity; Electrodes; Endocytosis; Environmental Exposure; Environmental Monitoring; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Esophageal and Gastric Varices; Esters; Fagopyrum; Female; Ferrosoferric Oxide; Flame Retardants; Flavobacteriaceae; Flow Cytometry; Follow-Up Studies; Formoterol Fumarate; Fusarium; Garlic; Gastrointestinal Hemorrhage; Gene Expression; Genes, Plant; Genetic Markers; Glial Fibrillary Acidic Protein; Gliosis; Global Health; Glutathione Transferase; Glycine max; Gum Arabic; Hemostasis, Endoscopic; Hepatocytes; Hippocampus; Humans; Hydrogen-Ion Concentration; Illinois; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infant, Newborn; Infant, Small for Gestational Age; Injections, Intraperitoneal; Interleukin-4; Iowa; Iron; Ki-67 Antigen; Kidney; Kinetics; Kynurenine; Lakes; Levofloxacin; Lipid Peroxidation; Lipids; Liver; Liver Cirrhosis, Experimental; Magnetic Fields; Magnetic Iron Oxide Nanoparticles; Male; Manure; Maze Learning; Memory, Short-Term; Metal Nanoparticles; Metals, Heavy; Methane; Mice; Mice, Inbred C57BL; Mice, Knockout; Michigan; Microalgae; Microbial Consortia; Mitochondria; Models, Animal; Models, Chemical; Models, Neurological; Molecular Structure; Molecular Weight; Mutation; Myeloid-Derived Suppressor Cells; NADPH Oxidase 2; Neoplasm Recurrence, Local; Neurites; Neurons; Neuroprotective Agents; NF-kappa B; NIH 3T3 Cells; Nitric Oxide Synthase Type II; Nitrogen; Ohio; Ointments; Ontario; Organelle Biogenesis; Organophosphates; Organophosphorus Compounds; Oxidative Stress; Palladium; Particle Size; Pectins; Phenotype; Phytotherapy; Piperidines; Placenta; Plant Diseases; Plant Extracts; Polymers; Polymorphism, Genetic; Polyphenols; Powders; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Protein Kinase Inhibitors; Protein Structure, Secondary; Proteins; Pyridines; Pyrimidines; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Receptors, Chemokine; Receptors, Formyl Peptide; Receptors, Lipoxin; Recovery of Function; Recurrence; Reference Standards; Reference Values; Reproducibility of Results; Respiratory Function Tests; Retrospective Studies; Risk; Sensitivity and Specificity; Sewage; Signal Transduction; Sodium Glutamate; Soil; Solanum tuberosum; Solubility; Solutions; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spermatozoa; STAT3 Transcription Factor; Sulfamethoxazole; Tea; Temperature; Thermodynamics; Thrombin; Treatment Outcome; Triazoles; United States; Viscosity; Waste Disposal, Fluid; Wastewater; Water; Water Pollutants, Chemical; Water Purification; White Matter; Wisconsin; X-Ray Diffraction; Zea mays | 2013 |
TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial.
Topics: Adult; Biomarkers; Enzyme Inhibitors; Fatty Acid Synthase, Type I; Female; Humans; Lipids; Lipogenesis; Liver; Liver Cirrhosis; Male; Middle Aged; Nitriles; Non-alcoholic Fatty Liver Disease; Piperidines; Single-Blind Method; Time Factors; Treatment Outcome; Triazoles; United States | 2021 |
Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study.
Topics: Adenine; Adult; Humans; Hydrazines; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Piperidines; Pyrazoles; Pyrimidines; Triazoles | 2022 |
179 other study(ies) available for triazoles and piperidines
| Article | Year |
|---|---|
[On the antiviral effect of a triazole compound (author's transl)].
Topics: Adsorption; Antiviral Agents; Coliphages; Escherichia coli; Nicotiana; Piperidines; Plants, Toxic; RNA Phages; Tobacco Mosaic Virus; Triazoles; Virus Replication | 1979 |
Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils.
Topics: Azepines; Calcimycin; Calcium; Cytosol; Dinoprostone; Eosinophils; Histamine; Histamine Antagonists; Humans; In Vitro Techniques; Lung; Mast Cells; Neutrophils; Piperidines; Platelet Activating Factor; Prostaglandin D2; Secretory Rate; SRS-A; Triazoles | 1992 |
Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Azepines; Clemastine; Coronary Disease; Coronary Vessels; Guinea Pigs; Organoselenium Compounds; Ouabain; Piperidines; Platelet Activating Factor; Propranolol; Rats; Triazoles; Umbelliferones; Ventricular Fibrillation | 1992 |
Characterization of an accessory binding area in the histamine H2 receptor.
Topics: Animals; Binding Sites; Cerebral Cortex; Cimetidine; Guinea Pigs; Heart Atria; Histamine H2 Antagonists; Ileum; Male; Piperidines; Ranitidine; Receptors, Histamine H2; Structure-Activity Relationship; Triazoles | 1991 |
Intragastric acidity and serum gastrin after sufotidine.
Topics: Gastric Acid; Gastrins; Histamine H2 Antagonists; Humans; Piperidines; Triazoles | 1990 |
Chronic administration of H2-antagonists does not alter gastric secretory responses to histamine, or the antisecretory activity of sufotidine.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Male; Mice; Mice, Inbred C57BL; Piperidines; Triazoles | 1990 |
Gas-liquid chromatographic resolution of some racemic synthons for lamtidine analogous histamine H2-receptor antagonists via diastereomeric amides of (1S)-(-)-camphanic acid.
Topics: Amides; Chromatography, Gas; Histamine H2 Antagonists; Piperidines; Stereoisomerism; Terpenes; Triazoles | 1989 |
Radiosensitizing hypoxic cells with new 3-nitro-1,2,4-triazole derivatives in vitro and in vivo.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Chemical Phenomena; Chemistry; Nitro Compounds; Piperazines; Piperidines; Pyrrolidines; Radiation-Sensitizing Agents; Triazoles | 1989 |
[H2-antihistaminics. 33. Synthesis and H2-antagonistic activity of heteroaromatic (thio)carboxamides and triazole(thi)one-derivatives of piperidinomethylphenoxypropylamine].
Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Piperidines; Thiadiazoles; Thioamides; Thiones; Triazoles | 1987 |
[H2-antihistaminics. 36. Isolamtidine and analogs].
Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Muscle, Smooth; Piperidines; Rats; Triazoles | 1987 |
Pharmacological profile of new histamine H2-receptor antagonists related to cimetidine, ranitidine and lamtidine.
Topics: Animals; Cimetidine; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Male; Piperidines; Rana temporaria; Ranitidine; Rats; Receptors, Histamine H2; Stomach; Triazoles | 1988 |
[Alkyl- and alkoxy-substituted lamtidine analogs: synthesis and H2-antagonistic activity. 38. H2-antihistaminics].
Topics: Animals; Chemical Phenomena; Chemistry; Histamine H2 Antagonists; Magnetic Resonance Spectroscopy; Male; Piperidines; Rats; Spectrophotometry, Infrared; Triazoles | 1988 |
Histamine H2-receptor blocking activity of ranitidine and lamtidine analogues containing aminomethyl-substituted aliphatic systems.
Topics: Animals; Chemical Phenomena; Chemistry; Gastric Acid; Gastric Mucosa; Guinea Pigs; Heart Rate; Histamine H2 Antagonists; Ileum; Piperidines; Rana temporaria; Ranitidine; Rats; Structure-Activity Relationship; Triazoles | 1988 |
Basic metabolites of trazodone in humans.
Topics: Chromatography, Thin Layer; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methods; Piperazines; Piperidines; Psychotropic Drugs; Pyridines; Spectrophotometry, Ultraviolet; Triazoles | 1974 |
Centrally acting isosteric Mannich bases.
Topics: Animals; Azoles; Benzimidazoles; Chemistry, Pharmaceutical; Cyanosis; Indoles; Mice; Motor Activity; Piperazines; Piperidines; Pyrrolidines; Seizures; Triazoles | 1968 |
The effect of triazole on RNA viruses.
Topics: Antiviral Agents; Piperidines; RNA Phages; Tobacco Mosaic Virus; Triazoles; Viral Plaque Assay | 1980 |
Comparison of antisecretory potency and duration of action of the H2-receptor antagonists AH 22216, cimetidine, ranitidine and SK & F 93479 in the dog.
Topics: Animals; Cimetidine; Dogs; Furans; Gastric Acid; Guanidines; Histamine H2 Antagonists; Male; Piperidines; Pyrimidinones; Ranitidine; Time Factors; Triazoles | 1983 |
Irreversible and specific inactivation by AH 22216 of histamine H2 receptors in the human gastric cancer cell line HGT-1.
Topics: Cell Line; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Histamine; Humans; Piperidines; Receptors, Histamine; Receptors, Histamine H2; Stomach; Triazoles; Vasoactive Intestinal Peptide | 1983 |
Potent and specific blockade by AH 22216 of histamine-H2-receptor-mediated acid secretion in isolated rabbit gastric cells.
Topics: Aminopyrine; Animals; Cimetidine; Gastric Acid; Gastric Mucosa; Histamine; Male; Piperidines; Rabbits; Receptors, Histamine; Receptors, Histamine H2; Triazoles | 1983 |
Histamine H3 receptor-mediated modulation of water consumption in the rat.
Topics: Animals; Drinking; Histamine; Histamine Antagonists; Male; Methylhistamines; Nicotinic Acids; Piperidines; Pyrilamine; Rats; Receptors, Histamine; Receptors, Histamine H3; Tetrazoles; Triazoles | 1993 |
Interactions between the effects of basal forebrain lesions and chronic treatment with MDL 26,479 on learning and markers of cholinergic transmission.
Topics: Animals; Antidepressive Agents; Autoradiography; Biomarkers; Body Weight; Choline O-Acetyltransferase; Conditioning, Operant; Hemicholinium 3; Ibotenic Acid; Immunohistochemistry; Learning; Neuromuscular Depolarizing Agents; Parasympathetic Nervous System; Piperidines; Prosencephalon; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Synaptic Transmission; Triazoles | 1993 |
N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.
Topics: Animals; Biological Availability; Drug Stability; Ferrets; Guinea Pigs; Humans; Inflammation; Macaca mulatta; Male; Microsomes, Liver; Migraine Disorders; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Triazoles; Vomiting | 1996 |
Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin; Succinates; Sulfonamides; Thromboxane A2; Triazoles; Vasoconstrictor Agents | 1996 |
Effects of UR-12633, a new antagonist of platelet-activating factor, in rodent models of endotoxic shock.
Topics: Analysis of Variance; Animals; Azepines; Blood Pressure; Cell Membrane; Disease Models, Animal; Escherichia coli; Hypotension; Lipopolysaccharides; Male; Mice; Piperidines; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Shock, Septic; Triazoles | 1996 |
Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets.
Topics: Animals; Antiemetics; Antineoplastic Agents; Blood Proteins; Brain Chemistry; Cell Line; Cisplatin; Diterpenes; Ferrets; Guinea Pigs; Indoles; Ligands; Male; Neurokinin-1 Receptor Antagonists; Neurotoxins; Piperidines; Radioligand Assay; Receptors, Neurokinin-1; Triazoles; Vomiting | 1996 |
Structure-activity characterization of an H2-receptor antagonist, 3-amino-4-[4-[4-(1-piperidinomethyl)-2-pyridyloxy]-cis-2-++ +butenylamino]- 3-cyclobutene-1,2-dione hydrochloride (T-066), involved in the insurmountable antagonism against histamine-induce
Topics: Animals; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Molecular Structure; Piperidines; Pyridines; Structure-Activity Relationship; Triazoles | 1998 |
Coronary side-effect potential of current and prospective antimigraine drugs.
Topics: Adolescent; Adult; Aged; Angina Pectoris; Child; Coronary Vessels; Dihydroergotamine; Ergotamine; Female; Humans; In Vitro Techniques; Indoles; Male; Methysergide; Middle Aged; Migraine Disorders; Piperidines; Sulfonamides; Sumatriptan; Triazoles; Tryptamines; Vasoconstrictor Agents | 1998 |
New "triptans" and other drugs for migraine.
Topics: Adrenergic beta-Antagonists; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Dihydroergotamine; Drug Interactions; Ergotamine; Humans; Indoles; Methysergide; Migraine Disorders; Naproxen; Oxazoles; Oxazolidinones; Piperidines; Propranolol; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Sumatriptan; Time Factors; Timolol; Triazoles; Tryptamines; Valproic Acid; Vasoconstrictor Agents | 1998 |
Heterogeneous platelet-activating factor (PAF) receptors and calcium increase in platelets and macrophages.
Topics: Animals; Azepines; Blood Platelets; Calcium; Cytosol; Humans; Loratadine; Macrophages; Male; Piperidines; Platelet Membrane Glycoproteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1999 |
Effects of histamine H2 receptor agonists and antagonists on the isolated guinea pig gallbladder.
Topics: Animals; Benzothiazoles; Dopamine Agents; Famotidine; Gallbladder; Guanidines; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Phenoxypropanolamines; Piperidines; Pyridines; Receptors, Histamine H2; Sincalide; Thiazoles; Triazoles | 1999 |
Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.
Topics: Animals; Binding, Competitive; Cell Line; Cold Temperature; COS Cells; HeLa Cells; Humans; Indoles; Kinetics; Oxazoles; Oxazolidinones; Piperidines; Pyrrolidines; Radioligand Assay; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Sumatriptan; Triazoles; Tritium; Tryptamines | 1999 |
Sensitization of visceral afferents to bradykinin in rat jejunum in vitro.
Topics: Adenosine; Animals; Bradykinin; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Histamine; Histamine Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Naproxen; Neurons, Afferent; Piperidines; Ranitidine; Rats; Rats, Inbred Strains; Serotonin; Stimulation, Chemical; Triazines; Triazoles; Xanthines | 1999 |
Determination of antimigraine compounds rizatriptan, zolmitriptan, naratriptan and sumatriptan in human serum by liquid chromatography/electrospray tandem mass spectrometry.
Topics: Bufotenin; Chromatography, High Pressure Liquid; Humans; Indoles; Mass Spectrometry; Migraine Disorders; Molecular Structure; Oxazoles; Oxazolidinones; Piperidines; Sensitivity and Specificity; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines; Vasoconstrictor Agents | 2000 |
The effects of nitroxide radicals on oxidative DNA damage.
Topics: Amidines; Animals; Cattle; Copper; Cyclic N-Oxides; DNA; DNA Damage; DNA, Bacterial; DNA, Recombinant; Free Radical Scavengers; Free Radicals; Heterocyclic Compounds, 2-Ring; Hydrogen Peroxide; Hydroxylamines; Iron; Oxidants; Oxidative Stress; Piperidines; Quinolones; Spin Labels; Triazoles | 2000 |
Triptans to the rescue: effective therapy for migraine headaches in the workplace.
Topics: Absenteeism; Adult; Cost-Benefit Analysis; Efficiency; Female; Humans; Indoles; Injections, Subcutaneous; Male; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Randomized Controlled Trials as Topic; Self Administration; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines; Workplace | 2000 |
A comment on time-to-event analysis for headache relief.
Topics: Analgesics; Headache; Humans; Indoles; Oxazolidinones; Piperidines; Randomized Controlled Trials as Topic; Serotonin Receptor Agonists; Sumatriptan; Time Factors; Triazoles; Tryptamines | 2000 |
Activation mechanisms of nucleoside phosphoramidate prodrugs.
Topics: Amides; Furans; Kinetics; Magnetic Resonance Spectroscopy; Nucleosides; Phosphoric Acids; Piperidines; Prodrugs; Thymidine; Triazoles | 2000 |
Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers.
Topics: Alkaloids; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cimetidine; Diltiazem; Excipients; Furans; Humans; Hydrogen-Ion Concentration; Imidazoles; Intestinal Absorption; Naphthalenes; Phenytoin; Piperidines; Poloxamer; Polyethylene Glycols; Povidone; Propranolol; Solubility; Triazoles | 2000 |
Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition.
Topics: Animals; Antigens; Azepines; Benzoquinones; Bronchoconstriction; Butyrophenones; Eicosapentaenoic Acid; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Indomethacin; Male; Methacholine Chloride; Phospholipases A; Phospholipases A2; Piperidines; Respiratory Hypersensitivity; Triazoles | 2001 |
Anti-Helicobacter pylori agents endowed with H2-antagonist properties.
Topics: Animals; Anti-Bacterial Agents; Benzoates; Binding, Competitive; Combinatorial Chemistry Techniques; Dose-Response Relationship, Drug; Drug Resistance; Guinea Pigs; Heart Atria; Helicobacter pylori; Histamine; Histamine H2 Antagonists; Metronidazole; Microbial Sensitivity Tests; Nitriles; Piperidines; Receptors, Histamine H2; Structure-Activity Relationship; Triazoles | 2001 |
Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis.
Topics: Administration, Oral; Adult; Double-Blind Method; Humans; Indoles; Migraine Disorders; Nausea; Oxazolidinones; Piperidines; Randomized Controlled Trials as Topic; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines; Vasoconstrictor Agents | 2001 |
Researchers explore new anti-HIV agents.
Topics: Anti-HIV Agents; CCR5 Receptor Antagonists; Clinical Trials as Topic; Cyclic N-Oxides; Drugs, Investigational; Enfuvirtide; Furans; HIV; HIV Envelope Protein gp120; HIV Envelope Protein gp41; HIV Infections; HIV Integrase Inhibitors; Humans; Nitriles; Oximes; Peptide Fragments; Piperazines; Piperidines; Pyridazines; Pyridines; Pyrimidines; Reverse Transcriptase Inhibitors; Triazoles | 2002 |
Comparison of triptan tablet consumption per attack: a prospective study of migraineurs in Spain.
Topics: Female; Humans; Indoles; Male; Migraine Disorders; Oxazolidinones; Piperidines; Prospective Studies; Serotonin Receptor Agonists; Sumatriptan; Tablets; Triazoles; Tryptamines | 2002 |
Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages.
Topics: Animals; Azepines; Base Sequence; Cells, Cultured; DNA Primers; Hydrolysis; Imidazoles; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Organophosphorus Compounds; Phosphorylation; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Thapsigargin; Triazoles | 2002 |
Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; CD11c Antigen; CD4 Antigens; Cell Cycle; Cell Differentiation; Diacylglycerol Kinase; Enzyme Activators; Enzyme Inhibitors; Farnesol; Flow Cytometry; Genes, fos; Genes, jun; Humans; Immunoblotting; Isoenzymes; Leukemia, Myeloid; Naphthalenes; Oncogene Protein p21(ras); Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Sulfonamides; Thiazoles; Triazoles; Tumor Cells, Cultured | 2002 |
Restoring migraine sufferers' ability to function normally: a comparison of rizatriptan and other triptans in randomized trials.
Topics: Administration, Oral; Adolescent; Adult; Aged; Female; Humans; Indoles; Male; Middle Aged; Migraine Disorders; Oxazolidinones; Piperidines; Randomized Controlled Trials as Topic; Retrospective Studies; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines | 2002 |
Synthesis and properties of adducts of a hindered amine and 2-hydroxyphenylbenzotriazole as novel polymer stabilizers.
Topics: Drug Stability; Kinetics; Methylmethacrylates; Molecular Weight; Photochemistry; Piperidines; Spectrophotometry, Ultraviolet; Triazoles | 2002 |
Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Genes, MDR; Humans; Indoles; Injections, Intravenous; Male; Mice; Mice, Mutant Strains; Miconazole; Microsomes, Liver; Oxazolidinones; Oxidoreductases, N-Demethylating; Phenotype; Piperidines; Pyrrolidines; Recombinant Proteins; Statistics as Topic; Sumatriptan; Triazoles; Troleandomycin; Tryptamines | 2003 |
Investigation of the effects of naratriptan, rizatriptan, and sumatriptan on jugular venous oxygen saturation in anesthetized pigs: implications for their mechanism of acute antimigraine action.
Topics: Anesthesia; Animals; Blood Gas Analysis; Hemodynamics; Indoles; Jugular Veins; Male; Migraine Disorders; Oxygen; Piperidines; Sumatriptan; Swine; Triazoles; Tryptamines; Vasoconstriction; Vasoconstrictor Agents | 2003 |
[Highly selective beginning. Associated symptoms and side effects in retrospect].
Topics: Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines | 2003 |
Synthesis and evaluation of in vitro antimycobacterial activity of some 5-(5-nitro-2-thienyl)-2-(piperazinyl, piperidinyl and morpholinyl)-1,3,4-thiadiazole derivatives.
Topics: Antitubercular Agents; Indicators and Reagents; Microbial Sensitivity Tests; Morpholines; Mycobacterium tuberculosis; Piperazines; Piperidines; Thiazoles; Triazoles | 2003 |
Potent imidazole and triazole CB1 receptor antagonists related to SR141716.
Topics: Imidazoles; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Triazoles | 2004 |
AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Benzoxazines; Calcium; Calcium Channel Blockers; Cerebellum; Chelating Agents; Colforsin; Cyclopropanes; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Wistar; Receptors, AMPA; Ryanodine; Synapses; Triazines; Triazoles | 2004 |
Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.
Topics: Animals; Benzamides; Brain; Carbazoles; Dinoprost; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelium, Vascular; Female; Forecasting; Guinea Pigs; Iliac Artery; Indoles; Ketanserin; Male; Muscle Contraction; Muscle, Smooth; Oxadiazoles; Oxazolidinones; Piperazines; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Sumatriptan; Triazoles; Tryptamines | 2004 |
The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig.
Topics: Animals; Autoreceptors; Cerebral Cortex; Chromatography, High Pressure Liquid; Citalopram; Fluoxetine; Guinea Pigs; Hypothalamus; Indoles; Male; Membrane Glycoproteins; Membrane Transport Proteins; Microdialysis; Nerve Tissue Proteins; Piperidines; Piperidones; Pyrimidines; Rats; Rats, Inbred Strains; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Presynaptic; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Plasma Membrane Transport Proteins; Species Specificity; Spiro Compounds; Subcellular Fractions; Triazoles; Tritium; United Kingdom | 2004 |
Correlation between lipophilicity and triptan outcomes.
Topics: Central Nervous System Diseases; Chemical Phenomena; Chemistry, Physical; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Statistics as Topic; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines | 2005 |
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.
Topics: Administration, Oral; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Hypotension; Hypothermia; Imidazoles; Mice; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2005 |
Triptans induce vasoconstriction of human arteries and veins from the thoracic wall.
Topics: Aged; Aged, 80 and over; Arteries; Dose-Response Relationship, Drug; Female; Humans; Indoles; Male; Middle Aged; Oxazolidinones; Piperidines; Polymerase Chain Reaction; Serotonin Receptor Agonists; Sumatriptan; Thorax; Triazoles; Tryptamines; Vasoconstriction; Veins | 2005 |
Triptans for migraine therapy: a comparison based on number needed to treat and doses needed to treat.
Topics: Algorithms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Costs; Humans; Managed Care Programs; Migraine Disorders; Piperidines; Pyrrolidines; Recurrence; Serotonin Receptor Agonists; Time Factors; Treatment Outcome; Triazoles; Tryptamines | 2005 |
Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.
Topics: Algorithms; Analgesics; Animals; Behavior, Animal; Benzothiazoles; Brain; Cimetidine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Injections, Intraventricular; Male; Mice; Molecular Structure; Pain; Pain Measurement; Phenoxypropanolamines; Piperidines; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Triazoles | 2005 |
Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides.
Topics: Animals; Binding Sites; Cyclohexanols; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Triazoles; Vas Deferens | 2006 |
[Medical treatment of migraine attacks in the child].
Topics: Acetaminophen; Age Factors; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Ergot Alkaloids; Humans; Ibuprofen; Life Style; Migraine Disorders; Oxazolidinones; Parents; Patient Education as Topic; Pediatrics; Piperidines; Pyrrolidines; Risk Factors; Serotonin Receptor Agonists; Sumatriptan; Taste Disorders; Triazoles; Tryptamines; Vasoconstrictor Agents | 2006 |
Prevention of dyskinesia by an NMDA receptor antagonist in MPTP monkeys: effect on adenosine A2A receptors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Dyskinesia Agents; Antiparkinson Agents; Benzoxazoles; Denervation; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Female; Image Processing, Computer-Assisted; In Situ Hybridization; Levodopa; Macaca fascicularis; Motor Activity; Neuroprotective Agents; Oligonucleotide Probes; Ovariectomy; Parkinson Disease, Secondary; Piperidines; Pyrimidines; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Triazoles | 2006 |
Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.
Topics: Animals; Anti-Obesity Agents; Blood-Brain Barrier; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanes; Cyclohexanols; Eating; Ethanol; Feeding Behavior; Male; Maze Learning; Membranes, Artificial; Motor Activity; Permeability; Phenols; Piperidines; Pyrazoles; Rats; Rats, Wistar; Rats, Zucker; Rimonabant; Self Administration; Triazoles | 2006 |
Mouse spinal cord compression injury is reduced by either activation of the adenosine A2A receptor on bone marrow-derived cells or deletion of the A2A receptor on non-bone marrow-derived cells.
Topics: Adenosine A2 Receptor Agonists; Analysis of Variance; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Mice; Mice, Knockout; Motor Activity; Myelin Sheath; Piperidines; Radioligand Assay; Receptor, Adenosine A2A; Spinal Cord Compression; Time Factors; Triazines; Triazoles | 2006 |
Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts.
Topics: Animals; Cisplatin; Colonic Neoplasms; Enzyme Inhibitors; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Semaphorin-3A; Signal Transduction; Triazoles; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2006 |
Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles.
Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases, Type I; Drug Screening Assays, Antitumor; Humans; Imidazoles; Indenes; Isoquinolines; Lactams; Models, Molecular; Morpholines; Piperazines; Piperidines; Pyrazoles; Structure-Activity Relationship; Topoisomerase I Inhibitors; Triazoles | 2006 |
Beta2-agonists and paresthesias in multiple sclerosis.
Topics: Adrenergic beta-Agonists; Albuterol; Amantadine; Analgesics, Non-Narcotic; Androstadienes; Aromatase Inhibitors; Asthma; Bronchodilator Agents; Donepezil; Drug Therapy, Combination; Female; Fluticasone; Food Hypersensitivity; Humans; Indans; Interferons; Latex Hypersensitivity; Letrozole; Mandelic Acids; Middle Aged; Multiple Sclerosis; Nebulizers and Vaporizers; Nitriles; Nootropic Agents; Parasympatholytics; Paresthesia; Piperidines; Respiratory Function Tests; Salmeterol Xinafoate; Thyroxine; Triazoles | 2007 |
Attenuation of reperfusion lung injury and apoptosis by A2A adenosine receptor activation is associated with modulation of Bcl-2 and Bax expression and activation of extracellular signal-regulated kinases.
Topics: Adenosine A2 Receptor Agonists; Animals; Apoptosis; bcl-2-Associated X Protein; Cats; Extracellular Signal-Regulated MAP Kinases; Lung; Lung Injury; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Piperidines; Proto-Oncogene Proteins c-bcl-2; Pulmonary Alveoli; Receptor, Adenosine A2A; Reperfusion Injury; Triazines; Triazoles; Wounds and Injuries | 2007 |
Identification of nonpeptide CCR5 receptor agonists by structure-based virtual screening.
Topics: Amino Acid Sequence; CCR5 Receptor Antagonists; Models, Molecular; Molecular Sequence Data; Molecular Structure; Piperazines; Piperidines; Protein Structure, Tertiary; Pyridazines; Pyrrolidines; Quantitative Structure-Activity Relationship; Quinazolines; Receptors, CCR5; Sequence Homology, Amino Acid; Triazoles | 2007 |
Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; Antigens, CD; Antigens, Differentiation; CD3 Complex; CD40 Ligand; CTLA-4 Antigen; Cytokines; Graft Rejection; Interferon-gamma; Interleukin-2 Receptor alpha Subunit; Isoantigens; Lymphocyte Activation; Mice; Mice, Knockout; Piperidines; Programmed Cell Death 1 Receptor; Receptor, Adenosine A2A; Reperfusion Injury; Skin Transplantation; T-Lymphocytes; Triazines; Triazoles; ZAP-70 Protein-Tyrosine Kinase | 2007 |
Glutamate levels in cerebrospinal fluid and triptans overuse in chronic migraine.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Glutamic Acid; Headache Disorders; Headache Disorders, Secondary; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Serotonin Receptor Agonists; Triazoles; Tryptamines | 2007 |
Enhancement of the antitumor activity of tamoxifen and anastrozole by the farnesyltransferase inhibitor lonafarnib (SCH66336).
Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Apoptosis; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Female; G1 Phase; Humans; In Situ Nick-End Labeling; Mice; Mice, Nude; Neoplasm Transplantation; Nitriles; Ovariectomy; Piperidines; Pyridines; S Phase; Tamoxifen; Triazoles | 2007 |
Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cyclic AMP; Horses; Immunoenzyme Techniques; Lipopolysaccharides; Monocytes; Phenethylamines; Piperidines; Receptor, Adenosine A2A; Regression Analysis; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2008 |
Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor.
Topics: Amides; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Calcium; CCR5 Receptor Antagonists; Cell Line; Cell Membrane; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Cyclic N-Oxides; Cyclohexanes; HIV Fusion Inhibitors; Humans; Macaca mulatta; Maraviroc; Mice; Molecular Sequence Data; Oximes; Piperidines; Precursor Cells, B-Lymphoid; Pyridines; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, CCR5; Sequence Homology, Amino Acid; Species Specificity; Transfection; Triazoles | 2007 |
SAR maps: a new SAR visualization technique for medicinal chemists.
Topics: CDC2 Protein Kinase; Chemistry, Pharmaceutical; Drug Design; Models, Molecular; Molecular Conformation; Piperazines; Piperidines; Stereoisomerism; Structure-Activity Relationship; Triazoles; Vascular Endothelial Growth Factor Receptor-2 | 2007 |
Activation of adenosine 2A receptors preserves structure and function of podocytes.
Topics: Adenosine A2 Receptor Agonists; Albuminuria; Animals; Diabetic Nephropathies; Mice; Mice, Inbred C57BL; Piperidines; Podocytes; Proteinuria; Purine Nucleosides; Receptors, Adenosine A2; Triazines; Triazoles | 2008 |
Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists.
Topics: Amides; Amino Acid Sequence; Animals; Anti-HIV Agents; Benzoates; Binding Sites; CCR5 Receptor Antagonists; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Diketopiperazines; HIV Fusion Inhibitors; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Maraviroc; Membrane Fusion; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Piperazines; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrimidines; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, CCR5; Sequence Homology, Amino Acid; Spiro Compounds; Static Electricity; Transfection; Triazoles | 2008 |
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage.
Topics: Acrylamides; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Survival; Copper; Humans; NAD; Piperidines; Triazoles | 2008 |
Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives.
Topics: Animals; Anti-Obesity Agents; CHO Cells; Cricetinae; Cricetulus; Humans; Imidazoles; Isomerism; Models, Chemical; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Solubility; Structure-Activity Relationship; Thiazoles; Triazoles; Water | 2008 |
Anti-HIV agents. Is PF-232798 a possible successor to maraviroc?
Topics: Azabicyclo Compounds; CD4 Lymphocyte Count; Cyclohexanes; HIV Fusion Inhibitors; HIV Infections; Humans; Imidazoles; Maraviroc; Piperidines; Triazoles; Tropanes; Viral Load | 2008 |
Effects of a hindered amine light stabilizer and a UV light absorber used in maxillofacial elastomers on human gingival epithelial cells and fibroblasts.
Topics: Cell Line; Cell Membrane; Cell Proliferation; Cell Survival; Colorimetry; Coloring Agents; Decanoic Acids; Epithelial Cells; Fibroblasts; Gingiva; Humans; L-Lactate Dehydrogenase; Materials Testing; Maxillofacial Prosthesis; Piperidines; Silicone Elastomers; Spectrophotometry; Tetrazolium Salts; Thiazoles; Time Factors; Triazoles | 2008 |
1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: part 2.
Topics: Animals; Anti-HIV Agents; Butanes; Caco-2 Cells; CCR5 Receptor Antagonists; Cell Line; Dogs; HIV Infections; Humans; Piperidines; Rats; Receptors, CCR5; Stereoisomerism; Triazoles | 2009 |
Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues.
Topics: Animals; Cattle; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Epididymis; Genitalia, Male; Immunoblotting; Immunohistochemistry; Indoles; Isoleucine; Male; Organ Specificity; Piperidines; Pyrazines; Rats; Sitagliptin Phosphate; Species Specificity; Spermatozoa; Testis; Triazoles | 2009 |
Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CXCL1; Dinoprostone; Gastric Mucosa; Indomethacin; Inflammation; Interleukin-1beta; Male; Peroxidase; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Stomach Ulcer; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2009 |
Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.
Topics: Animals; Benzimidazoles; Chemistry, Pharmaceutical; Crystallography, X-Ray; Dipeptidyl-Peptidase IV Inhibitors; Dogs; Drug Design; Glucagon-Like Peptide 1; Humans; Hydrolysis; Imidazoles; Inhibitory Concentration 50; Macaca mulatta; Mice; Piperidines; Pyrazines; Pyridines; Rats; Sitagliptin Phosphate; Triazoles | 2009 |
Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum.
Topics: Action Potentials; Animals; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cerebral Cortex; Corpus Striatum; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Glycine; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mice, Knockout; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Phenylacetates; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Adenosine A2; Synapses; Triazines; Triazoles | 2009 |
Rizatriptan. Comparative trial results.
Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Migraine Disorders; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Time Factors; Treatment Outcome; Triazoles; Tryptamines; Vasoconstrictor Agents; Young Adult | 2000 |
Lipopolysaccharide and TNF-alpha modify adenosine A(2A) receptor expression and function in equine monocytes.
Topics: Adenosine A2 Receptor Agonists; Animals; Animals, Newborn; Base Sequence; DNA Primers; Horse Diseases; Horses; Humans; In Vitro Techniques; Lipopolysaccharides; Mice; Monocytes; Piperidines; Radioligand Assay; Receptor, Adenosine A2A; Recombinant Proteins; RNA, Messenger; Systemic Inflammatory Response Syndrome; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2010 |
Pesticide cocktails can interact synergistically on aquatic crustaceans.
Topics: Animals; Daphnia; Dose-Response Relationship, Drug; Drug Synergism; Fungicides, Industrial; Imidazoles; Insecticides; Morpholines; Piperidines; Pyrethrins; Toxicity Tests; Triazoles; Water Pollutants, Chemical | 2010 |
Investigations into the source of two fungicides measured in the air for 24 hours following application to a cereal crop.
Topics: Aerosols; Agriculture; Air Pollutants; Dust; Edible Grain; Epoxy Compounds; Fungicides, Industrial; Particle Size; Piperidines; Time Factors; Triazoles; Wind | 2009 |
Oral oxytocin antagonists.
Topics: Administration, Oral; Animals; Biological Availability; Camphor; Humans; Indoles; Oxytocin; Piperazines; Piperidines; Protein Conformation; Pyrrolidines; Receptors, Oxytocin; Sulfonamides; Triazoles | 2010 |
Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
Topics: Amino Acid Substitution; Anticonvulsants; Antidepressive Agents; Antifungal Agents; Brain; Catalytic Domain; Cholesterol; Cholesterol 24-Hydroxylase; Clotrimazole; Crystallography, X-Ray; Humans; Mutation, Missense; Piperidines; Protein Binding; Pyrimidines; Steroid Hydroxylases; Structure-Activity Relationship; Tranylcypromine; Triazoles; Voriconazole | 2010 |
An analysis of the impact of FDA's guidelines for addressing cardiovascular risk of drugs for type 2 diabetes on clinical development.
Topics: Adamantane; Allylamine; Cardiovascular Diseases; Colesevelam Hydrochloride; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Insulin; Investigational New Drug Application; Liraglutide; Nitriles; Peptides; Piperidines; Practice Guidelines as Topic; Pyrazines; Pyrrolidines; Randomized Controlled Trials as Topic; Sitagliptin Phosphate; Time Factors; Triazoles; United States; United States Food and Drug Administration; Uracil; Venoms; Vildagliptin | 2011 |
Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Corticosterone; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Expressed Emotion; Fear; Fluorobenzenes; Male; Mice; Neurokinin-1 Receptor Antagonists; Phobic Disorders; Physical Conditioning, Animal; Piperidines; Psychopathology; Triazoles; Up-Regulation | 2011 |
Synthesis, spectral, crystal structure and in vitro antimicrobial evaluation of imidazole/benzotriazole substituted piperidin-4-one derivatives.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Crystallography, X-Ray; Fungi; Imidazoles; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Piperidines; Stereoisomerism; Triazoles | 2011 |
Bivalent dopamine D2 receptor ligands: synthesis and binding properties.
Topics: Animals; Antipsychotic Agents; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Humans; Ligands; Piperazines; Piperidines; Protein Multimerization; Radioligand Assay; Receptors, Dopamine D2; Structure-Activity Relationship; Swine; Triazoles | 2011 |
Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies.
Topics: Animals; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase 5; Flavonoids; Fluorine; Hippocampus; Humans; Hydrogen Bonding; Mice; Models, Molecular; Molecular Structure; Neuroprotective Agents; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Triazoles | 2011 |
In vitro and in vivo pharmacological characterisation of the potent and selective vasopressin V(1A) receptor antagonist 4-[4-(4-Chloro-phenyl)-5-[1,2,3]triazol-2-ylmethyl-4H-[1,2,4]triazol-3-yl]-piperidin-1-yl-(3,5-difluoro-phenyl) methanone (PF-00738245)
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Aorta; Arginine Vasopressin; Blood Circulation; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Dogs; Female; Humans; Male; Models, Biological; Myometrium; Piperidines; Rats; Receptors, Oxytocin; Receptors, Vasopressin; Substrate Specificity; Triazoles | 2011 |
Effects of DPP-4 inhibitors on the heart in a rat model of uremic cardiomyopathy.
Topics: Animals; Area Under Curve; Cardiomyopathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gene Expression Regulation; Glomerular Filtration Rate; Glucagon-Like Peptide 1; Heart; Humans; Kidney Failure, Chronic; Linagliptin; Myocardium; Natriuretic Peptide, Brain; Nephrectomy; Piperidines; Purines; Pyrazines; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sitagliptin Phosphate; Triazoles; Uracil; Uremia | 2011 |
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Topics: Acetylcholinesterase; Alzheimer Disease; Azo Compounds; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Indoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Piperidines; Spiro Compounds; Structure-Activity Relationship; Temperature; Thiazoles; Thiosemicarbazones; Triazoles | 2012 |
Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
Topics: Animals; Brain; Dogs; Drug Discovery; Humans; Hypnotics and Sedatives; Magnetic Resonance Spectroscopy; Models, Molecular; Orexin Receptors; Piperidines; Protein Binding; Pyridines; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep; Sleep Initiation and Maintenance Disorders; Stereoisomerism; Structure-Activity Relationship; Triazoles; Wakefulness | 2012 |
Synthesis and biological evaluation of triazole derivatives as potential antifungal agent.
Topics: Antifungal Agents; Catalytic Domain; Fungi; Humans; Microbial Sensitivity Tests; Models, Molecular; Mycoses; Piperidines; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles | 2012 |
[Therapeutic use and adverse events of incretin-related drugs].
Topics: Adamantane; Aged; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Linagliptin; Liraglutide; Nitriles; Peptides; Piperidines; Purines; Pyrazines; Pyrrolidines; Quinazolines; Sitagliptin Phosphate; Triazoles; Uracil; Venoms; Vildagliptin | 2012 |
A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site.
Topics: Adamantane; Catalytic Domain; Crystallography, X-Ray; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Multiprotein Complexes; Nitriles; Oligopeptides; Piperidines; Protein Binding; Protein Interaction Mapping; Pyrazines; Pyrazoles; Pyrrolidines; Serine; Sitagliptin Phosphate; Structure-Activity Relationship; Thiazolidines; Triazoles; Uracil; Vildagliptin; X-Ray Diffraction | 2013 |
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.
Topics: Animals; Benzodioxoles; Enzyme Inhibitors; HEK293 Cells; Humans; Mice; Monoacylglycerol Lipases; Piperazine; Piperazines; Piperidines; Rats; Substrate Specificity; Triazoles; Urea | 2013 |
A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.
Topics: Animals; Axin Protein; beta Catenin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Enzyme Inhibitors; Genes, APC; Humans; Mice; Mutation; Piperidines; Spheroids, Cellular; Sulfones; Tankyrases; Triazoles; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2013 |
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition.
Topics: Administration, Oral; Animals; Attention; Azabicyclo Compounds; Choice Behavior; Cognition; Cytoskeletal Proteins; Diazepam; Eszopiclone; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Macaca mulatta; Male; Memory, Short-Term; Nerve Tissue Proteins; Orexin Receptors; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Recognition, Psychology; Sleep; Task Performance and Analysis; Time Factors; Triazoles; Zolpidem | 2013 |
Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism.
Topics: Animals; Eating; Ghrelin; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Triazoles | 2013 |
GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.
Topics: Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cohort Studies; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Female; Fulvestrant; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glial Cell Line-Derived Neurotrophic Factor; Humans; Kaplan-Meier Estimate; Letrozole; MCF-7 Cells; Middle Aged; Nitriles; Oligonucleotide Array Sequence Analysis; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Triazoles | 2013 |
Insomnia: chasing the dream.
Topics: Animals; Arousal; Azabicyclo Compounds; Azepines; Benzodiazepines; Cognitive Behavioral Therapy; Doxepin; Dreams; Histamine Agonists; Histamine Antagonists; Humans; Hypnotics and Sedatives; Hypothalamus; Orexin Receptors; Piperazines; Piperidines; Receptors, G-Protein-Coupled; Receptors, GABA; Receptors, Histamine H3; Receptors, Neuropeptide; Sleep Initiation and Maintenance Disorders; Triazoles | 2013 |
Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats.
Topics: Animals; Azabicyclo Compounds; Brain; Electroencephalography; Eszopiclone; GABA-A Receptor Agonists; Male; Orexin Receptor Antagonists; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Sleep Stages; Triazoles; Zolpidem | 2013 |
Design, synthesis and trypanocidal evaluation of novel 1,2,4-triazoles-3-thiones derived from natural piperine.
Topics: Alkaloids; Benzodioxoles; Drug Design; Inhibitory Concentration 50; Molecular Structure; Parasitic Sensitivity Tests; Piperidines; Polyunsaturated Alkamides; Thiones; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity.
Topics: Antifungal Agents; Aspergillus flavus; Aspergillus niger; Cryptococcus neoformans; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Piperidines; Pyridines; Structure-Activity Relationship; Triazoles | 2013 |
Effects of dipeptidyl peptidase-4 inhibitors in a type 2 diabetes patient with failure of glucagon-like peptide-1 receptor agonists.
Topics: Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Exenatide; Fasting; Female; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Insulin Glargine; Insulin, Long-Acting; Metformin; Middle Aged; Peptides; Piperidines; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Treatment Failure; Triazoles; Venoms | 2014 |
Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Drug Design; Humans; Mice; Microsomes, Liver; Models, Molecular; Piperidines; Triazoles | 2013 |
Exploration of N-(2-aminoethyl)piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor.
Topics: Antineoplastic Agents; Benzamides; Binding Sites; Cell Line, Tumor; Cell Proliferation; Hep G2 Cells; Humans; Imatinib Mesylate; K562 Cells; Mitogen-Activated Protein Kinase 1; Molecular Docking Simulation; Niacinamide; Piperazines; Piperidines; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-abl; Pyrimidines; Pyrrolidines; Structure-Activity Relationship; Triazoles; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
[Effect of different plant growth regulators on yield and quality of Angelica dahurica var. formosana development].
Topics: Angelica; Chlormequat; Gibberellins; Maleic Hydrazide; Piperidines; Plant Growth Regulators; Triazoles | 2013 |
Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.
Topics: Dose-Response Relationship, Drug; Drug Discovery; Endocannabinoids; Enzyme Inhibitors; Humans; Lipoprotein Lipase; Molecular Structure; Piperidines; Structure-Activity Relationship; Triazoles; Urea | 2013 |
Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6).
Topics: Animals; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Humans; Mice; Models, Animal; Molecular Structure; Monoacylglycerol Lipases; Piperidines; Structure-Activity Relationship; Triazoles; Urea | 2013 |
Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors.
Topics: Benzamides; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Conformation; Quaternary Ammonium Compounds; Structure-Activity Relationship; Triazoles | 2013 |
Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis.
Topics: Amino Acid Sequence; Amino Acids; Dimethylformamide; Fluorenes; Microwaves; Organophosphorus Compounds; Peptides; Piperidines; Solid-Phase Synthesis Techniques; Solvents; Stereoisomerism; Triazoles | 2014 |
Pharmacoeconomic analysis of DPP-4 inhibitors.
Topics: Adamantane; Clinical Trials as Topic; Cohort Studies; Cost-Benefit Analysis; Costs and Cost Analysis; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Nitriles; Piperidines; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Uracil; Vildagliptin | 2013 |
72nd annual meeting of the American Academy of Dermatology.
Topics: Antifungal Agents; Attention Deficit Disorder with Hyperactivity; Boron Compounds; Botulinum Toxins, Type A; Bridged Bicyclo Compounds, Heterocyclic; Brimonidine Tartrate; Depression; Dermatitis, Atopic; Food Hypersensitivity; Humans; Immunologic Factors; Ivermectin; Phosphodiesterase Inhibitors; Phototherapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinoxalines; Skin Diseases; Societies, Medical; Thalidomide; Triazoles; United States | 2014 |
Histamine H3 receptor activation counteracts adenosine A2A receptor-mediated enhancement of depolarization-evoked [3H]-GABA release from rat globus pallidus synaptosomes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Biphenyl Compounds; gamma-Aminobutyric Acid; Globus Pallidus; Histamine Agonists; Histamine H3 Antagonists; Imidazoles; Male; Membrane Potentials; Nitriles; Phenethylamines; Piperidines; Potassium; Pyrrolidines; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Histamine H3; Synaptosomes; Thiourea; Triazines; Triazoles; Tritium | 2014 |
Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains.
Topics: Antifungal Agents; Candida albicans; Cryptococcus neoformans; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Triazoles | 2014 |
Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells.
Topics: Benzoquinones; Blotting, Western; Carbazoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Ligands; Lung Neoplasms; Mutation; Oncogene Proteins, Fusion; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Transforming Growth Factor alpha; Triazoles | 2014 |
Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.
Topics: Adenine; Animals; Azepines; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Drug Synergism; Humans; I-kappa B Kinase; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, SCID; Nuclear Proteins; Piperidines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyrazoles; Pyrimidines; Signal Transduction; Transcription Factors; Triazoles; Xenograft Model Antitumor Assays | 2014 |
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators.
Topics: Animals; Azabicyclo Compounds; Azepines; Benzimidazoles; Brain; Cross-Over Studies; Dogs; Electroencephalography; Eszopiclone; GABA Modulators; Hypnotics and Sedatives; Intracellular Signaling Peptides and Proteins; Macaca mulatta; Male; Mice, Inbred C57BL; Neurons; Neuropeptides; Orexin Receptor Antagonists; Orexins; Piperazines; Piperidines; Rats, Sprague-Dawley; Rats, Transgenic; Sleep; Sleep Deprivation; Sleep Stages; Species Specificity; Triazoles; Wakefulness | 2014 |
Unprecedented therapeutic potential with a combination of A2A/NR2B receptor antagonists as observed in the 6-OHDA lesioned rat model of Parkinson's disease.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Benzothiazoles; Drug Therapy, Combination; Levodopa; Mass Spectrometry; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Piperidines; Purines; Pyrimidines; Rats; Receptors, N-Methyl-D-Aspartate; Triazoles | 2014 |
Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Topics: CCR5 Receptor Antagonists; Chemokine CX3CL1; Crystallography, X-Ray; Cyclohexanes; Humans; Ligands; Maraviroc; Piperidines; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Chemokine; Receptors, CXCR4; Triazoles; Viral Proteins | 2015 |
Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydrazines; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Piperidines; Pyrazoles; Pyrimidines; Triazoles; Xenograft Model Antitumor Assays | 2015 |
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Topics: Animals; Dogs; Half-Life; Mice; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Protein Binding; Pyrimidines; Rats; Sleep Initiation and Maintenance Disorders; Structure-Activity Relationship; Triazoles | 2015 |
Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.
Topics: Adenosine A2 Receptor Antagonists; Benzopyrans; Drug Design; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Molecular Docking Simulation; Piperidines; Quinazolines; Receptor, Adenosine A2A; Triazoles | 2015 |
Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Azepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Lymphoma, Mantle-Cell; Mice, Inbred NOD; Mice, SCID; NF-kappa B; Nuclear Proteins; Piperidines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyrazoles; Pyrimidines; Transcription Factor RelA; Transcription Factors; Triazoles | 2015 |
Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro.
Topics: Apoptosis; Azetidines; Chlorophenols; Colonic Neoplasms; HCT116 Cells; Humans; Liposomes; Mitogen-Activated Protein Kinase Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Polyethylene Glycols; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Triazoles | 2015 |
Retrospective and Prospective Human Intravenous and Oral Pharmacokinetic Projection of Dipeptidyl peptidase-IV Inhibitors Using Simple Allometric Principles - Case Studies of ABT-279, ABT-341, Alogliptin, Carmegliptin, Sitagliptin and Vildagliptin.
Topics: Adamantane; Administration, Intravenous; Administration, Oral; Animals; Biphenyl Compounds; Dipeptidyl-Peptidase IV Inhibitors; Dogs; Haplorhini; Humans; Nitriles; Piperidines; Prospective Studies; Pyridines; Pyrrolidines; Quinolizines; Rats; Retrospective Studies; Sitagliptin Phosphate; Triazoles; Uracil; Vildagliptin | 2015 |
Involvement of CCL3/CCR5 Signaling in Dorsal Root Ganglion in Remifentanil-induced Hyperalgesia in Rats.
Topics: Analgesics, Opioid; Animals; CCR5 Receptor Antagonists; Chemokine CCL3; Cyclohexanes; Disease Models, Animal; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Maraviroc; Piperidines; Rats, Sprague-Dawley; Receptors, CCR5; Remifentanil; RNA, Messenger; Touch; Triazoles | 2016 |
Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.
Topics: Allosteric Regulation; Animals; CHO Cells; Cricetulus; Humans; Models, Molecular; Piperidines; Pyridines; Receptors, Metabotropic Glutamate; Triazoles | 2016 |
Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys.
Topics: Animals; Arousal; Conditioning, Classical; Cross-Over Studies; Diazepam; Eszopiclone; GABA Agents; Hypnotics and Sedatives; Macaca mulatta; Male; Orexin Receptor Antagonists; Orexins; Piperidines; Polysomnography; Signal Transduction; Sleep; Sleep Stages; Triazoles; Wakefulness | 2016 |
Click-based synthesis and antitubercular evaluation of novel dibenzo[b,d]thiophene-1,2,3-triazoles with piperidine, piperazine, morpholine and thiomorpholine appendages.
Topics: Antitubercular Agents; Cell Survival; Click Chemistry; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Morpholines; Mycobacterium tuberculosis; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship; Thiophenes; Triazoles | 2016 |
Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.
Topics: Animals; Azepines; Camptothecin; DNA Topoisomerases, Type I; Ebolavirus; Flavonoids; Gene Expression Regulation; HEK293 Cells; Hemorrhagic Fever, Ebola; Host-Pathogen Interactions; Humans; Immunity, Innate; Inflammation; Influenza A virus; Interferon-beta; Mice; Mice, Inbred C57BL; Piperidines; Positive Transcriptional Elongation Factor B; RNA Polymerase II; Sendai virus; Staphylococcal Infections; Staphylococcus aureus; Topoisomerase I Inhibitors; Topotecan; Transcription, Genetic; Triazoles | 2016 |
CuAAC click chemistry with N-propargyl 1,5-dideoxy-1,5-imino-D-gulitol and N-propargyl 1,6-dideoxy-1,6-imino-D-mannitol provides access to triazole-linked piperidine and azepane pseudo-disaccharide iminosugars displaying glycosidase inhibitory properties.
Topics: 1-Deoxynojirimycin; alpha-Glucosidases; Azides; beta-Amylase; beta-Glucosidase; Click Chemistry; Disaccharides; Enzyme Inhibitors; Glucose; Heterocyclic Compounds, 1-Ring; Hordeum; Imino Sugars; Mannitol; Pargyline; Piperidines; Propylamines; Prunus dulcis; Saccharomyces cerevisiae; Triazoles | 2016 |
JMV2894, a novel growth hormone secretagogue, accelerates body mass recovery in an experimental model of cachexia.
Topics: Animals; Animals, Newborn; Antineoplastic Agents; Body Weight; Cachexia; Calcium; CHO Cells; Cisplatin; Cricetinae; Cricetulus; Eating; Growth Hormone; Indoles; Male; Muscle, Skeletal; Piperidines; Rats; Rats, Wistar; Receptors, Ghrelin; Triazoles; Wasting Disease, Chronic | 2017 |
Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and CYP Enzyme Substrates Sildenafil, Amlodipine, Tolbutamide, and Repaglinide.
Topics: Adult; Amlodipine; Area Under Curve; Carbamates; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation; Healthy Volunteers; Humans; In Vitro Techniques; Male; Middle Aged; Piperidines; Sildenafil Citrate; Thioglycolates; Tolbutamide; Triazoles; Young Adult | 2017 |
The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.
Topics: Acetylcholine; Animals; gamma-Aminobutyric Acid; Hippocampus; Histamine; Hypothalamic Area, Lateral; Male; Orexin Receptor Antagonists; Piperidines; Prefrontal Cortex; Rats; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Wakefulness | 2017 |
2017 New Drug Update.
Topics: Anti-Inflammatory Agents; Antipsychotic Agents; Drugs, Investigational; Dry Eye Syndromes; Gout Suppressants; Humans; Hypoglycemic Agents; Insulin, Long-Acting; Peptides; Phenylalanine; Piperidines; Sulfones; Thioglycolates; Triazoles; Urea | 2017 |
Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor.
Topics: Allosteric Regulation; Allosteric Site; Animals; Biphenyl Compounds; CHO Cells; Cricetinae; Cricetulus; Humans; Indans; Ligands; Mutation; Piperidines; Protein Binding; Pyridines; Receptors, Metabotropic Glutamate; Triazoles | 2017 |
Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2.
Topics: Allosteric Regulation; Animals; CHO Cells; Cricetulus; Excitatory Amino Acid Agonists; Kinetics; Piperidines; Pyridines; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sleep, REM; Structure-Activity Relationship; Triazoles; Tritium | 2017 |
GSK2586184, a JAK1 selective inhibitor, in two patients with ulcerative colitis.
Topics: Adult; Azetidines; C-Reactive Protein; Clinical Trials as Topic; Colitis, Ulcerative; Humans; Janus Kinase 1; Leukocyte L1 Antigen Complex; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Severity of Illness Index; Triazoles | 2017 |
Selective inhibition of physiological late Na
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Disease Models, Animal; Female; Heart Rate; Heart Ventricles; In Vitro Techniques; Isolated Heart Preparation; Kinetics; Myocytes, Cardiac; Piperidines; Pyridines; Rabbits; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Triazoles | 2018 |
Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia.
Topics: Animals; Autophagy; Biomarkers; Body Weight; Cachexia; Cisplatin; Disease Models, Animal; Forkhead Box Protein O3; Growth Hormone; Indoles; Male; Mitochondria; Mitochondrial Dynamics; Muscle, Skeletal; Oligopeptides; Organ Size; Organelle Biogenesis; Oxidative Stress; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; Rats; Secretagogues; Triazoles | 2017 |
The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase 9; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Enhancer Elements, Genetic; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Mice; Piperidines; Proteins; Pyrazines; RNA Polymerase II; RNA-Binding Proteins; Transcription Factors; Triazoles; Xenograft Model Antitumor Assays | 2018 |
Isavuconazole for the treatment of invasive fungal disease in patients receiving ibrutinib.
Topics: Adenine; Antifungal Agents; Humans; Invasive Fungal Infections; Nitriles; Piperidines; Pyrazoles; Pyridines; Pyrimidines; Treatment Outcome; Triazoles | 2019 |
Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis.
Topics: Animals; Benzoates; Biphenyl Compounds; Brain; Calcium; Carbamates; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Mice; Mitochondria; Molecular Targeted Therapy; Monoacylglycerol Lipases; N-Methylaspartate; Neural Conduction; Piperidines; Pyramidal Tracts; Receptor, Cannabinoid, CB1; Triazoles | 2018 |
The Impact of Ghrelin on the Survival and Efficacy of Dopaminergic Fetal Grafts in the 6-OHDA-Lesioned Rat.
Topics: Animals; Cell Survival; Dopaminergic Neurons; Female; Ghrelin; Indoles; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Triazoles | 2018 |
XPO1 Inhibitor Selinexor Overcomes Intrinsic Ibrutinib Resistance in Mantle Cell Lymphoma via Nuclear Retention of IκB.
Topics: Adenine; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Exportin 1 Protein; Humans; Hydrazines; I-kappa B Proteins; Karyopherins; Lymphoma, Mantle-Cell; NF-kappa B; Piperidines; Protein Subunits; Pyrazoles; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Triazoles | 2018 |
The Bruton tyrosine kinase inhibitor zanubrutinib (BGB-3111) demonstrated synergies with other anti-lymphoma targeted agents.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Combined Chemotherapy Protocols; Bridged Bicyclo Compounds, Heterocyclic; Cell Proliferation; Drug Synergism; Humans; Hydrazines; Lymphoma, B-Cell; Lymphoma, Mantle-Cell; Niacinamide; Piperidines; Pyrazoles; Pyrimidines; Sulfonamides; Triazoles; Tumor Cells, Cultured | 2019 |
Efficacy of the novel CDK7 inhibitor QS1189 in mantle cell lymphoma.
Topics: Adenine; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lymphoma, Mantle-Cell; Phosphorylation; Piperidines; Pyrazoles; Pyrimidines; RNA Polymerase II; Sulfonamides; Triazoles | 2019 |
Differential Effects of a Full and Biased Ghrelin Receptor Agonist in a Mouse Kindling Model.
Topics: Animals; Benzazepines; beta-Arrestins; Brain; Dopamine Agonists; Glycine; Indoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Piperidines; Quinazolinones; Receptors, Ghrelin; Triazoles; Tryptophan | 2019 |
The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model.
Topics: Animals; Pharmaceutical Preparations; Piperidines; Rats; Rodentia; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles | 2020 |
Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Cell Line; Cytokines; Enzyme Assays; Female; Healthy Volunteers; Heterocyclic Compounds, 3-Ring; Humans; Inhibitory Concentration 50; Janus Kinase 1; Janus Kinase Inhibitors; Male; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Receptors, Cytokine; Sulfonamides; Triazoles | 2019 |
Neuraminidase from Influenza A and B Viruses is Susceptible to the Compound 4-(4-Phenyl-1H-1,2,3-Triazol-1-yl)-2,2,6,6-Tetramethylpiperidine-1- Oxyl.
Topics: Antiviral Agents; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Influenza A virus; Influenza B virus; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Neuraminidase; Piperidines; Structure-Activity Relationship; Thiazoles; Triazoles | 2020 |
Relative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in comparison to adalimumab in patients with active rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Bayes Theorem; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome; Triazoles | 2020 |
Ibrutinib related cerebral aspergillosis successfully treated with isavuconazole: a case report.
Topics: Adenine; Antifungal Agents; Aspergillosis; Humans; Nitriles; Piperidines; Pyridines; Triazoles | 2020 |
BSA Binding, molecular docking and in vitro biological screening of some new 1, 2, 4-triazole heterocycles bearing azinane nucleus.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Cholinesterase Inhibitors; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Piperidines; Serum Albumin; Structure-Activity Relationship; Triazoles | 2020 |
Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Genes, ras; Heterografts; Humans; Indoles; Male; MAP Kinase Signaling System; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Recurrence, Local; Neuroblastoma; Piperidines; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyridones; Pyrimidines; Pyrimidinones; Pyrroles; Triazoles; Vemurafenib | 2020 |
Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Central Nervous System Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Exportin 1 Protein; Female; Humans; Hydrazines; Karyopherins; Lymphoma, Non-Hodgkin; Macrophages; Mice; Mice, Nude; Piperidines; Receptors, Cytoplasmic and Nuclear; Survival Rate; Triazoles; Tumor Cells, Cultured; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2020 |
Bromodomain-containing-protein-4 and cyclin-dependent-kinase-9 inhibitors interact synergistically in vitro and combined treatment reduces post-traumatic osteoarthritis severity in mice.
Topics: Animals; Anterior Cruciate Ligament Injuries; Arthritis, Experimental; Azepines; Cartilage, Articular; Cattle; Chondrocytes; Cyclin-Dependent Kinase 9; Flavonoids; Glycosaminoglycans; Humans; In Vitro Techniques; Interleukin-1beta; Interleukin-6; Mice; Nuclear Proteins; Osteoarthritis, Knee; Piperidines; Protein Kinase Inhibitors; Severity of Illness Index; Transcription Factors; Triazoles; Tumor Necrosis Factor-alpha | 2021 |
Multicomponent synthesis and anti-proliferative screening of biaryl triazole-containing cyclophanes.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cycloaddition Reaction; Drug Screening Assays, Antitumor; Ethers, Cyclic; Humans; Piperidines; Structure-Activity Relationship; Triazoles | 2021 |
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding.
Topics: Adult; Breast Feeding; Female; Humans; Infant; Infant, Newborn; Migraine Disorders; Milk, Human; Oxazolidinones; Piperidines; Pyrrolidines; Triazoles; Tryptamines | 2021 |
The Dual Orexin Receptor Antagonist DORA-22 Improves Mild Stress-induced Sleep Disruption During the Natural Sleep Phase of Nocturnal Rats.
Topics: Animals; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Rats; Sleep; Triazoles | 2021 |
JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Cells, Cultured; Cytokines; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Janus Kinases; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Sulfonamides; Triazoles | 2021 |
Structure-Activity Relationship of Heterocyclic P2Y
Topics: Animals; Binding Sites; Disease Models, Animal; Drug Design; Humans; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Neuralgia; Piperidines; Prodrugs; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Solubility; Structure-Activity Relationship; Triazoles | 2021 |
Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata.
Topics: Administration, Topical; Alopecia Areata; Animals; Azetidines; CD8-Positive T-Lymphocytes; Cytokines; Isonicotinic Acids; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Macrophages; Mice, Inbred C3H; Nitriles; NK Cell Lectin-Like Receptor Subfamily K; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Triazoles | 2021 |
Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart.
Topics: Adult; Atrial Fibrillation; Calcium; Cnidarian Venoms; ERG1 Potassium Channel; Heart Atria; Humans; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Piperidines; Pyridines; Ranolazine; Sodium; Triazoles | 2021 |
Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Triazoles | 2021 |
Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer.
Topics: Androgen Receptor Antagonists; Androgens; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Naphthalenes; Piperidines; Pyrrolidines; Radiation Tolerance; Receptors, Androgen; Receptors, Estrogen; Tamoxifen; Thiazoles; Triazoles | 2022 |
FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models.
Topics: Actins; Animals; Carcinoma, Hepatocellular; Cytokines; Disease Models, Animal; Fatty Acid Synthase, Type I; Fatty Acid Synthases; Humans; Inflammation; Lipopolysaccharides; Liver Cirrhosis; Liver Neoplasms; Mice; Nitriles; Non-alcoholic Fatty Liver Disease; Piperidines; Triazoles; Triglycerides | 2022 |