Compounds > indoxacarb
Page last updated: 2024-09-24

indoxacarb

Description

indoxacarb: oxadiazine insecticide; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

insecticide : Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID107720
CHEMBL ID197676
CHEBI ID38630
SCHEMBL ID22073
MeSH IDM0352808

Synonyms (60)

Synonym
dpx-kn 128
indeno(1,2-e)(1,3,4)oxadiazine-4a(3h)-carboxylic acid, 7-chloro-2,5-dihydro-2-(((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)amino)carbonyl)-, methyl ester, (4as)-
hsdb 7280
provaunt
dpx-mp 062-381
avent
advion
avatar
methyl (s)-7chloro-2,5-dihydro-2-(((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)amino)carbonylindeno(1,2-e)(1,3,4)oxadiazine-4a(3h)-carboxylate
avaunt
indoxacarb [iso]
indoxacarb
CHEBI:38630 ,
steward
methyl (4as)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]carbamoyl}-2,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a(3h)-carboxylate
D06316
173584-44-6
indoxacarb (jan)
NCGC00164264-02
insecticide
CHEMBL197676
methyl (4as)-7-chloro-2-[methoxycarbonyl-[4-(trifluoromethoxy)phenyl]carbamoyl]-3,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylate
NCGC00164264-03
C18569
dtxsid1032690 ,
cas-173584-44-6
tox21_300723
NCGC00254629-01
dtxcid9012690
unii-52h0d26mwr
dpx-mp062
52h0d26mwr ,
SCHEMBL22073
methyl (4as)-7-chloro-2,5-dihydro-2-(((methoxycarbonyl)(4-(trifluoromethoxy)phenyl)amino)carbonyl)indeno(1,2-e)(1,3,4)oxadiazine-4a(3h)-carboxylate
activyl
indoxacarb [hsdb]
indoxacarb (ema epar: veterinary)
activyl tick plus component indoxacarb
indoxacarb [jan]
indoxacarb [mi]
dpx-kn128
indoxacarb, (+)-
(+)-indoxacarb
indoxacarb component of activyl tick plus
indoxacarb, pestanal(r), analytical standard
indoxacarb 10 microg/ml in cyclohexane
VBCVPMMZEGZULK-NRFANRHFSA-N ,
(s)-methyl 7-chloro-2-(methoxycarbonyl(4-(trifluoromethoxy)phenyl)carbamoyl)-2,3,4a,5-tetrahydroindeno[1,2-e][1,3,4]oxadiazine-4a-carboxylate
174060-41-4
AS-35129
mfcd03792834
(+/-)-indoxacarb;dpx-jw 062; dpx-mp 062; tornado; tornado 10fl
(s)-indoxacarb
(4as)-indoxacarb
Q421469
AMY20519
AKOS037643748
(s)-indoxacarb 100 microg/ml in acetonitrile
()-indoxacarb;dpx-jw 062; dpx-mp 062; tornado; tornado 10fl
indeno[1,2-e][1,3,4]oxadiazine-4a(3h)-carboxylicacid,7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]-,methyl ester

Research Excerpts

Overview

ExcerptReference
"Indoxacarb is a widely used insecticide in the prevention and control of agricultural pests, whereas its negative effects on non-target organisms remain largely unclear. "( Chen, Y; Huang, Y; Li, Z; Ma, L; Wen, W; Wu, X; Xie, Q; Xu, H; Xu, Y; Yin, Z; Zhao, Y; Zhu, X, 2023)
"Indoxacarb is a typical chiral insecticide widely used in agricultural pest control. "( Li, Y; Liang, H; Qiu, L, 2021)
"Indoxacarb is an oxadiazine insecticide that is effective as an oral and contact insecticide against a broad spectrum of agricultural pests and, due to its unique site of action, no cross-resistance has been detected through mechanisms associated with resistance to insecticides currently used in public health."( Kitau, J; Malone, D; Mosha, FW; N'Guessan, R; Oxborough, RM; Rowland, MW; Tungu, PK, 2015)
"Indoxacarb is a highly potent insecticide widely used to control Lepidoptera insects in vegetable, tea, cotton, and rice fields. "( Fan, Y; Feng, Q; Huang, W; Lai, K; Li, QX; Zhang, C, 2017)
"Indoxacarb (INDOX) is a relatively new pesticide with a similar mode of action to that of tetrodotoxin (TTX)."( Brodie, ED; French, SS; Hansen, T; Neuman-Lee, LA, 2016)
"Indoxacarb is an important option for selective control of H."( Bird, LJ, 2017)
"Indoxacarb is an oxadiazine class sodium channel blocker insecticide used for German cockroach (Blattella germanica L.) control."( Cooper, B; Gondhalekar, AD; Nakayasu, ES; Scharf, ME; Silva, I, 2016)
"Indoxacarb is an important active ingredient extensively used for the control of Tuta absoluta, a major tomato pest, playing a particular role in insecticide resistance management schemes."( Mavridis, K; Morou, E; Riga, M; Rison, JL; Roditakis, E; Vasakis, E; Vontas, J, 2017)
"Indoxacarb is a recently introduced insecticide whose mode of action is blockage of voltage-gated sodium channels. "( Hsu, BG; Huang, HY; Lin, YL; Wu, YJ, 2010)
"Indoxacarb is a newly developed insecticide with high insecticidal activity and low toxicity to non-target organisms. "( Ikeda, T; Narahashi, T; Yeh, JZ; Zhao, X, 2003)
"Indoxacarb is a novel oxadiazine pro-insecticide that has no toxic effects on the adults, fecundity and eclosion of Amblyseius fallacis (Garman), a predacious phytoseiid, or Agistemus fleschneri Summers, a predacious stigmaeid. "( Bostanian, NJ; Hardman, JM; Larocque, N; Vincent, C, 2004)
"Indoxacarb is a slow-acting insecticide, so toxicity data were recorded 7 days post-treatment when the data had stabilised."( Akalach, M; Bostanian, NJ, 2006)
"Indoxacarb is an oxadiazine insecticide initially commercialized by DuPont for control of agricultural pests."( Akogbéto, M; Asidi, A; Boko, P; Bonnet, J; Corbel, V; N'Guessan, R; Odjo, A; Rowland, M; Yates, A, 2007)
"Indoxacarb is a new oxadiazine insecticide that has shown outstanding field insecticidal activity. "( Brady, EA; Connair, M; Hammes, GG; Sacher, M; Tillman, PG; Wing, KD, 2002)

Effects

ExcerptReference
"Indoxacarb has two enantiomers: (+)-S-indoxacarb and (-)-R-indoxacarb."( Wang, NM; Wang, ZJ; Xue, CB; Yu, QT, 2023)

Actions

ExcerptReference
"Indoxacarb did not cause block at any potential, yet it interfered with the ability of DCJW, but not RH 3421, to inhibit sodium current."( Silver, K; Soderlund, DM, 2005)

Treatment

ExcerptReference
"Indoxacarb treatment also reduced adult flea emergence from eggs for 5 weeks after treatment."( Dryden, MW; Heaney, K; Payne, PA; Smith, V; Sun, F, 2013)
"Treatment with indoxacarb provided 100% efficacy following infestations on day -2, 7, 14, 21 and 28 and efficacy was 99.6% following infestations on days 35 and 42. "( Dryden, MW; Heaney, K; Payne, PA; Smith, V; Sun, F, 2013)

Roles (1)

RoleDescription
voltage-gated sodium channel blockerAny sodium channel blocker that interferes with the activity of voltage-gated sodium channels.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
organochlorine insecticideAny organochlorine pesticide that has been used as an insecticide.
methyl esterAny carboxylic ester resulting from the formal condensation of a carboxy group with methanol.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (25)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency4.45010.006038.004119,952.5996AID1159521; AID1159523
GLI family zinc finger 3Homo sapiens (human)Potency6.38420.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency25.48570.000221.22318,912.5098AID1259243; AID1259247; AID743035; AID743036; AID743042; AID743053; AID743054; AID743063
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency41.82680.000657.913322,387.1992AID1259378
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency17.66750.001022.650876.6163AID1224838; AID1224893
progesterone receptorHomo sapiens (human)Potency29.28250.000417.946075.1148AID1346784; AID1346795
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency32.58020.000214.376460.0339AID720691; AID720692; AID720719
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency10.57610.003041.611522,387.1992AID1159552; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency1.45520.000817.505159.3239AID1159527; AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency10.92850.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency35.82570.375827.485161.6524AID743217; AID743220; AID743239
pregnane X nuclear receptorHomo sapiens (human)Potency1.66520.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency40.91760.000229.305416,493.5996AID1259244; AID1259248; AID743069; AID743075; AID743077; AID743078; AID743079; AID743080
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency28.19910.001024.504861.6448AID743227
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency24.35840.001019.414170.9645AID743094; AID743140
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency30.51970.023723.228263.5986AID743222; AID743241
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency14.84070.001723.839378.1014AID743083
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency29.870019.739145.978464.9432AID1159509
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency18.84670.057821.109761.2679AID1159526
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency11.78840.000323.4451159.6830AID743065; AID743067
heat shock protein beta-1Homo sapiens (human)Potency30.58900.042027.378961.6448AID743210; AID743228
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency30.50120.000627.21521,122.0200AID743202; AID743219
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency46.93050.001557.789015,848.9004AID1259244
Cellular tumor antigen p53Homo sapiens (human)Potency46.93050.002319.595674.0614AID651631; AID720552
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency46.93050.001551.739315,848.9004AID1259244
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (124)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (34)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (20)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID256017Lethal concentration required for 50% mortality in Fall armyworm2005Bioorganic & medicinal chemistry letters, Nov-15, Volume: 15, Issue:22
Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.
AID1104164Insecticidal activity against fourth-instar larval stage of Helicoverpa armigera field strain Pitoa isolated from maize plant assessed as mortality applied topically onto thorax measured after 48 hr2009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID1104144Resistance factor, ratio of LD50 for fourth-instar larval stage of Helicoverpa armigera field strain Ngong to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-772009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID1105349Insecticidal activity against Aedes aegypti assessed as insect mortality at 2 ppm2010Toxins, 08, Volume: 2, Issue:8
Natural toxins for use in pest management.
AID1104155Resistance factor, ratio of LD50 for fourth-instar larval stage of pyrethroid-resistance Helicoverpa armigera laboratory strain GS-RR06 to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-772009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID256019Lethal concentration required for 50% mortality in Diamondback moth2005Bioorganic & medicinal chemistry letters, Nov-15, Volume: 15, Issue:22
Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.
AID255461Ability to release internal calcium stores mediated by ryanodine receptor without activating voltage-gated calcium channel of cockroach in CMT assay; na = not applicable2005Bioorganic & medicinal chemistry letters, Nov-15, Volume: 15, Issue:22
Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.
AID1110973Antifeedant activity against third-instar larval stage of Trichoplusia ni (cabbage looper) infested compound-treated leaf assessed as time required to stop feeding at 244 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1111000Antifeedant activity against third-instar larval stage of Helicoverpa zea (corn earworm) infested compound-treated leaf assessed as time required to stop feeding at 244 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1110978Antifeedant activity against third-instar larval stage of Spodoptera exigua infested compound-treated leaf assessed as time required to stop feeding at 244 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1110992Antifeedant activity against third-instar larval stage of Helicoverpa zea (corn earworm) infested compound-treated leaf assessed as reduction in feeding damage at 244 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1110958Antifeedant activity against third-instar larval stage of Plutella xylostella (diamondback moth) infested compound-treated leaf assessed as time required to stop feeding at 244 mg a.i/L after 48 hr by leaf disk assay (Rvb = > 2880 min)2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1104142Resistance factor, ratio of LD50 for fourth-instar larval stage of Helicoverpa armigera field strain Gaschiga isolated from tomato plant to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-772009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID1110966Antifeedant activity against third-instar larval stage of Trichoplusia ni (cabbage looper) infested compound-treated leaf assessed as reduction in feeding damage at 244 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1104149Resistance factor, ratio of LD50 for fourth-instar larval stage of Helicoverpa armigera field strain Pitoa isolated from tomato plant to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-772009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID1104169Insecticidal activity against fourth-instar larval stage of pyrethroid-resistance Helicoverpa armigera laboratory strain GS-RR06 assessed as mortality applied topically onto thorax measured after 48 hr2009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID754213Insecticidal activity against second-instar larva of Sitobion avenae infected in cabbage leaves assessed as mortality after 5 days by leaf-disc method2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Bioactive terpenoids from the fruits of Aphanamixis grandifolia.
AID1104151Resistance factor, ratio of LD50 for fourth-instar larval stage of Helicoverpa armigera field strain Pitoa isolated from maize plant to LD50 for fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-772009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID1104163Insecticidal activity against fourth-instar larval stage of Helicoverpa armigera field strain Pitoa isolated from tomato plant assessed as mortality applied topically onto thorax measured after 48 hr2009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID256018Lethal concentration required for 50% mortality in Tobacco budworm2005Bioorganic & medicinal chemistry letters, Nov-15, Volume: 15, Issue:22
Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.
AID1104170Insecticidal activity against fourth-instar larval stage of pyrethroid-susceptible Helicoverpa armigera laboratory strain BK-77 assessed as mortality applied topically onto thorax measured after 48 hr2009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID1104156Insecticidal activity against fourth-instar larval stage of Helicoverpa armigera field strain Gaschiga isolated from tomato plant assessed as mortality applied topically onto thorax measured after 48 hr2009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID1110986Antifeedant activity against third-instar larval stage of Spodoptera exigua infested compound-treated leaf assessed as reduction in feeding damage at 244 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
AID1104159Insecticidal activity against fourth-instar larval stage of Helicoverpa armigera field strain Ngong isolated from cotton plant assessed as mortality applied topically onto thorax measured after 48 hr2009Pest management science, Oct, Volume: 65, Issue:10
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
AID1110951Antifeedant activity against third-instar larval stage of Plutella xylostella (diamondback moth) infested compound-treated leaf assessed as reduction in feeding damage at 244 mg a.i/L after 48 hr by leaf disk assay relative to untreated control2009Pest management science, Sep, Volume: 65, Issue:9
Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (196)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.51)18.2507
2000's58 (29.59)29.6817
2010's96 (48.98)24.3611
2020's41 (20.92)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (1.52%)5.53%
Reviews3 (1.52%)6.00%
Case Studies6 (3.03%)4.05%
Observational0 (0.00%)0.25%
Other186 (93.94%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
cypermethrin[no description available]medium60aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound		agrochemical;
molluscicide;
pyrethroid ester acaricide;
pyrethroid ester insecticide
methomyl[no description available]medium20aliphatic sulfide;
carbamate ester		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
nematicide;
xenobiotic
methoxyfenozide[no description available]medium90carbohydrazide;
monomethoxybenzene		environmental contaminant;
insecticide;
xenobiotic
pydrin, (s-(r*,r*))-isomer[no description available]medium10fenvalerateagrochemical;
pyrethroid ester insecticide
chlorantranilipole[no description available]medium160monochlorobenzenes;
organobromine compound;
pyrazole insecticide;
pyrazoles;
pyridines;
secondary carboxamide		ryanodine receptor agonist
ddt[no description available]medium10benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
endosulfan[no description available]medium30cyclic sulfite ester;
cyclodiene organochlorine insecticide		acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant
profenofos[no description available]medium10monochlorobenzenes;
organic thiophosphate;
organochlorine insecticide;
organophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
decamethrin[no description available]medium90aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organobromine compound		agrochemical;
antifeedant;
calcium channel agonist;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
pyrethroid ester insecticide
ethofenprox[no description available]medium10aromatic etherpyrethroid ether insecticide
metaldehyde[no description available]medium10tetroxocanefuel;
molluscicide
vulgarone b[no description available]medium10
piperine[no description available]medium10benzodioxoles;
N-acylpiperidine;
piperidine alkaloid;
tertiary carboxamide		food component;
human blood serum metabolite;
NF-kappaB inhibitor;
plant metabolite
thiamethoxam[no description available]medium10
dextrothyroxine[no description available]medium180
emamectin benzoate[no description available]medium100emamectins
cyantraniliprole[no description available]medium30nitrile;
organobromine compound;
organochlorine compound;
pyrazole insecticide;
pyridines;
secondary carboxamide		ryanodine receptor agonist
hydrazine[no description available]medium120azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
spinetoram[no description available]medium20organic molecular entity
fluphenacur[no description available]medium20aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
N-acylurea;
organofluorine compound
metaflumizone[no description available]medium80semicarbazone;
stilbenoid
kanamycin a[no description available]medium10kanamycinsbacterial metabolite
zinc oxide[no description available]medium10zinc molecular entity
aspartic acid[no description available]medium10aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one[no description available]medium10aromatic ether;
benzoxazine;
cyclic hydroxamic acid;
lactol		allelochemical;
plant metabolite
uridine diphosphate[no description available]medium10pyrimidine ribonucleoside 5'-diphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
phenylthiourea[no description available]medium20thioureasEC 1.14.18.1 (tyrosinase) inhibitor
acetone[no description available]medium10ketone body;
methyl ketone;
propanones;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent
diafenthiuron[no description available]medium20aromatic ether;
thiourea acaricide;
thiourea insecticide		oxidative phosphorylation inhibitor;
proinsecticide
3-octylthio-1,1,1-trifluoro-2-propanone[no description available]medium10
methane[no description available]medium20alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
acetonitrile[no description available]medium20aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
piperonyl butoxide[no description available]medium40benzodioxolespesticide synergist
betadex[no description available]medium10cyclodextrin
chlorpyrifos-methyl[no description available]medium10chloropyridine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
chlorpyrifos[no description available]medium50chloropyridine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
hydramethylnon[no description available]medium20hydramethylnon
fipronil[no description available]medium111(trifluoromethyl)benzenes;
dichlorobenzene;
nitrile;
primary amino compound;
pyrazoles;
sulfoxide
pyrimidinones[no description available]medium20
methylene blue[no description available]medium30organic chloride saltacid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer
pyrethrins[no description available]medium250
carbamothioic acid, s,s'-(2-(dimethylamino)-1,3-propanediyl) ester[no description available]medium10nereistoxin analogue insecticide
flubendiamide[no description available]medium10organofluorine insecticideryanodine receptor modulator
chlorine[no description available]medium10halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
atrazine[no description available]medium10chloro-1,3,5-triazine;
diamino-1,3,5-triazine		environmental contaminant;
herbicide;
xenobiotic
thiamethoxam[no description available]medium601,3-thiazoles;
2-nitroguanidine derivative;
organochlorine compound;
oxadiazane		antifeedant;
carcinogenic agent;
environmental contaminant;
neonicotinoid insectide;
xenobiotic
thiazoles[no description available]medium601,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
acephate[no description available]medium10mixed diacylamine;
organic thiophosphate;
organothiophosphate insecticide;
phosphoramide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
chlorfenapyr[no description available]medium50hemiaminal ether;
monochlorobenzenes;
nitrile;
organochlorine acaricide;
organochlorine insecticide;
organofluorine acaricide;
organofluorine insecticide;
pyrroles		proacaricide;
proinsecticide
cyhalothrin[no description available]medium60aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound;
organofluorine compound		agrochemical;
pyrethroid ester acaricide;
pyrethroid ester insecticide
imidacloprid[no description available]medium80imidacloprid;
imidazolidines;
monochloropyridine		environmental contaminant;
genotoxin;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
tebufenozide[no description available]medium40carbohydrazideecdysone agonist;
environmental contaminant;
xenobiotic
dimethoate[no description available]medium30monocarboxylic acid amide;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
bifenthrin[no description available]medium30carboxylic ester;
cyclopropanecarboxylate ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester acaricide;
pyrethroid ester insecticide
methoprene[no description available]medium11isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate;
isopropyl ester		juvenile hormone mimic
titanium[no description available]medium20titanium group element atom
spinosyn d[no description available]medium10spinosyn insecticide;
spinosyn		pediculicide
spinosyn a[no description available]medium10spinosyn insecticide;
spinosyn		pediculicide
permethrin[no description available]medium30cyclopropanecarboxylate ester;
cyclopropanes		agrochemical;
ectoparasiticide;
pyrethroid ester acaricide;
pyrethroid ester insecticide;
scabicide
epoxiconazole[no description available]medium10epoxide;
monochlorobenzenes;
monofluorobenzenes;
triazoles
triazoles[no description available]medium101,2,3-triazole
titanium dioxide[no description available]medium10titanium oxidesfood colouring
ketoconazole[no description available]medium11dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
chlorhexidine[no description available]medium11biguanides;
monochlorobenzenes		antibacterial agent;
antiinfective agent
lidocaine[no description available]medium30benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
phenyl acetate[no description available]medium10benzenes;
phenyl acetates
acequinocyl[no description available]medium101,4-naphthoquinones;
acetate ester		acaricide;
mitochondrial cytochrome-bc1 complex inhibitor
niacinamide[no description available]medium20pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
azadirachtin[no description available]medium20acetate ester;
azadirachtin;
cyclic hemiketal;
enoate ester;
epoxide;
methyl ester;
organic heterotetracyclic compound;
secondary alcohol;
tertiary alcohol		hepatoprotective agent
borneo[no description available]medium10organofluorine acaricide
prizes[no description available]medium10carboxamidine;
monochloropyridine;
nitrile		environmental contaminant;
neonicotinoid insectide;
xenobiotic
flonicamid[no description available]medium10nitrile;
organofluorine compound;
pyridinecarboxamide		environmental contaminant;
insecticide;
xenobiotic
thiacloprid[no description available]medium30monochloropyridine;
nitrile;
thiazolidines		environmental contaminant;
neonicotinoid insectide;
xenobiotic
oxazoles[no description available]medium201,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
1,2-dibenzoyl-tert-butylhydrazine[no description available]medium10bisacylhydrazine insecticide
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
tetrodotoxin[no description available]medium50azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
sodium nitrite[no description available]medium10inorganic sodium salt;
nitrite salt		antidote to cyanide poisoning;
antihypertensive agent;
antimicrobial food preservative;
food antioxidant;
poison
primaquine[no description available]medium10aminoquinoline;
aromatic ether;
N-substituted diamine		antimalarial
dapsone[no description available]medium10substituted aniline;
sulfone		anti-inflammatory drug;
antiinfective agent;
antimalarial;
leprostatic drug
chlorfluazuron[no description available]medium10benzoylurea insecticide;
dichlorobenzene;
organochlorine insecticide;
organofluorine insecticide
clothianidin[no description available]medium101,3-thiazoles;
2-nitroguanidine derivative;
clothianidin;
organochlorine compound		environmental contaminant;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
butyl phosphorotrithioate[no description available]medium10organic thiophosphatedefoliant
fenoxycarb[no description available]medium40aromatic ether;
carbamate ester		environmental contaminant;
insecticide;
juvenile hormone mimic;
xenobiotic
chlorine[no description available]medium10diatomic chlorine;
gas molecular entity		bleaching agent
tyrosine[no description available]medium10amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
phenylalanine[no description available]medium10amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
boric acid[no description available]medium10boric acidsastringent
valine[no description available]medium10L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
iprovalicarb[no description available]medium10amino acid amide;
carbamate ester;
valine derivative
carbamates[no description available]medium40amino-acid anion
aminoacetonitrile[no description available]medium10
pyrachlostrobin[no description available]medium10aromatic ether;
carbamate ester;
carbanilate fungicide;
methoxycarbanilate strobilurin antifungal agent;
monochlorobenzenes;
pyrazoles		antifungal agrochemical;
environmental contaminant;
mitochondrial cytochrome-bc1 complex inhibitor;
xenobiotic
fenamidone[no description available]medium10carbohydrazide;
imidazole fungicide;
imidazolone;
organic sulfide		antifungal agrochemical;
mitochondrial cytochrome-bc1 complex inhibitor;
quinone outside inhibitor
sodium bicarbonate[no description available]medium10one-carbon compound;
organic sodium salt		antacid;
food anticaking agent
propylene glycol[no description available]medium10glycol;
propane-1,2-diols		allergen;
human xenobiotic metabolite;
mouse metabolite;
protic solvent
cellulose[no description available]medium10glycoside
azinphosmethyl[no description available]medium30benzotriazines;
organic thiophosphate;
organothiophosphate insecticide		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
pyriproxyfen[no description available]medium10aromatic ether;
pyridines		juvenile hormone mimic
diflubenzuron[no description available]medium10benzoylurea insecticide;
monochlorobenzenes		insect sterilant
rh 3421[no description available]medium30
cadmium[no description available]medium10cadmium molecular entity;
zinc group element atom
methyl parathion[no description available]medium10C-nitro compound;
organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
genotoxin
carbaryl[no description available]medium10carbamate ester;
naphthalenes		acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant growth retardant
haloxyfop[no description available]medium10aromatic ether;
monocarboxylic acid;
organochlorine compound;
organofluorine compound;
pyridines
methanol[no description available]medium10alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
fenoxaprop ethyl[no description available]medium10aromatic ether
vancomycin[no description available]medium10glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
novaluron[no description available]medium10aromatic ether;
benzoylurea insecticide;
monochlorobenzenes;
organofluorine compound
kaolinite[no description available]medium10aluminosilicate mineral;
mixture		antidiarrhoeal drug;
excipient
thiodicarb[no description available]medium10
lanperisone[no description available]low002-methyl-3-(pyrrolidin-1-yl)-1-[4-(trifluoromethyl)phenyl]propan-1-oneantineoplastic agent;
calcium channel blocker;
ferroptosis inducer;
muscle relaxant;
voltage-gated sodium channel blocker
capsaicin[no description available]low00capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
methoxychlor[no description available]low00organochlorine insecticide
phosalone[no description available]low001,3-benzoxazoles;
carbamate ester;
organochlorine insecticide;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
dichlorodiphenyldichloroethane[no description available]low00chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		xenobiotic metabolite
chlorfenvinphos[no description available]low00dichlorobenzene;
organic phosphate;
organochlorine acaricide;
organochlorine insecticide;
organophosphate insecticide		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
mirex[no description available]low00chlorocarbon;
organochlorine insecticide		persistent organic pollutant
fluvalinate[no description available]low00(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
nitrile;
organochlorine acaricide;
organochlorine insecticide;
organofluorine acaricide;
organofluorine insecticide		agrochemical;
pyrethroid ester acaricide;
pyrethroid ester insecticide
azamethiphos[no description available]low00organic thiophosphate;
organochlorine acaricide;
organochlorine insecticide;
organothiophosphate insecticide		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
hexafluoron[no description available]low00aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
N-acylurea;
organochlorine insecticide;
organofluorine insecticide
pyridaben[no description available]low00organochlorine acaricide;
organochlorine insecticide;
pyridazinone		mitochondrial NADH:ubiquinone reductase inhibitor
pyraclofos[no description available]low00monochlorobenzenes;
organic thiophosphate;
organochlorine insecticide;
organosulfur compound;
organothiophosphate insecticide;
pyrazoles		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1h-pyrrole-3-carbonitrile[no description available]low00monochlorobenzenes;
nitrile;
organobromine compound;
organochlorine acaricide;
organochlorine insecticide;
organofluorine acaricide;
organofluorine insecticide;
pyrroles		acaricide;
antifouling biocide;
insecticide
dieldrin[no description available]low00epoxide;
organochlorine compound;
organochlorine insecticide		carcinogenic agent;
xenobiotic
tetrachlorvinphos[no description available]low00alkenyl phosphate;
dialkyl phosphate;
organochlorine insecticide;
organophosphate insecticide;
trichlorobenzene		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
s 1812[no description available]low00dichlorobenzene;
organochlorine insecticide;
organofluorine insecticide
amlodipine[no description available]low00dihydropyridine;
ethyl ester;
methyl ester;
monochlorobenzenes;
primary amino compound		antihypertensive agent;
calcium channel blocker;
vasodilator agent
arecoline[no description available]low00enoate ester;
methyl ester;
pyridine alkaloid;
tetrahydropyridine		metabolite;
muscarinic agonist
bay-k-8644[no description available]low00(trifluoromethyl)benzenes;
C-nitro compound;
dihydropyridine;
methyl ester
carpronium[no description available]low00methyl ester;
quaternary ammonium ion
amberlite cg 400[no description available]low00methyl ester;
organic heteropentacyclic compound;
yohimban alkaloid
dimethyl 2,3,5,6-tetrachloroterephthalate[no description available]low00diester;
methyl ester
felodipine[no description available]low00dichlorobenzene;
dihydropyridine;
ethyl ester;
methyl ester		anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent
isradipine[no description available]low00benzoxadiazole;
dihydropyridine;
isopropyl ester;
methyl ester
methyl salicylate[no description available]low00benzoate ester;
methyl ester;
salicylates		flavouring agent;
insect attractant;
metabolite
methylphenidate[no description available]low00beta-amino acid ester;
methyl ester;
piperidines
nicardipine[no description available]low00benzenes;
C-nitro compound;
diester;
dihydropyridine;
methyl ester;
tertiary amino compound
nifedipine[no description available]low00C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
nilvadipine[no description available]low00dihydropyridine;
isopropyl ester;
methyl ester;
nitrile
nisoldipine[no description available]low00C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
methyl ester
nitrendipine[no description available]low00C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
ethyl ester;
methyl ester		antihypertensive agent;
calcium channel blocker;
geroprotector;
vasodilator agent
reserpine[no description available]low00alkaloid ester;
methyl ester;
yohimban alkaloid		adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic
vincristine[no description available]low00acetate ester;
formamides;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
tertiary alcohol;
tertiary amino compound;
vinca alkaloid		antineoplastic agent;
drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
methyl acetate[no description available]low00acetate ester;
methyl ester;
volatile organic compound		EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor;
fragrance;
polar aprotic solvent
methylmethacrylate[no description available]low00enoate ester;
methyl ester		allergen;
polymerisation monomer
methyl n-methylanthranilate[no description available]low00benzoate ester;
methyl ester;
secondary amino compound;
substituted aniline		animal metabolite;
fungal metabolite;
plant metabolite
methyl benzoate[no description available]low00benzoate ester;
methyl ester		insect attractant;
metabolite
methyl formate[no description available]low00formate ester;
methyl ester;
volatile organic compound		fumigant;
insecticide;
polar aprotic solvent;
refrigerant
dimethyl 4-phthalate[no description available]low00diester;
methyl ester;
phthalate ester
deserpidine[no description available]low00alkaloid ester;
benzoate ester;
methyl ester;
organic heteropentacyclic compound;
yohimban alkaloid
dimethyl phthalate[no description available]low00diester;
methyl ester;
phthalate ester
methyl lactate[no description available]low00lactate ester;
methyl ester		metabolite
methyl pyruvate[no description available]low00methyl ester;
pyruvate ester
methyl hippurate[no description available]low00glycine derivative;
methyl ester		metabolite
vincamine[no description available]low00alkaloid ester;
hemiaminal;
methyl ester;
organic heteropentacyclic compound;
vinca alkaloid		antihypertensive agent;
metabolite;
vasodilator agent
4-aminobutyric acid methyl ester[no description available]low00amino acid ester;
methyl ester;
primary amino compound
monomethyl phthalate[no description available]low00methyl ester;
phthalic acid monoester
tabersonine[no description available]low00alkaloid ester;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound		antineoplastic agent;
metabolite
ng-nitroarginine methyl ester[no description available]low00alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
dichlorfop-methyl[no description available]low00aromatic ether;
dichlorobenzene;
diether;
methyl ester
vindesine[no description available]low00methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
primary carboxamide;
tertiary alcohol;
tertiary amino compound;
vinca alkaloid		antineoplastic agent
furalaxyl[no description available]low00alanine derivative;
aromatic amide;
carboxamide;
furans;
methyl ester
2-aminosulfonyl-benzoic acid methyl ester[no description available]low00benzoate ester;
methyl ester;
sulfonamide		marine xenobiotic metabolite
metalaxyl[no description available]low00alanine derivative;
aromatic amide;
carboxamide;
ether;
methyl ester
benalaxyl[no description available]low00alanine derivative;
aromatic amide;
carboxamide;
methyl ester
methyl bensulfuron[no description available]low00aromatic ether;
methyl ester;
N-sulfonylurea;
pyrimidines		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
esmolol[no description available]low00aromatic ether;
ethanolamines;
methyl ester;
secondary alcohol;
secondary amino compound
clopidogrel[no description available]low00methyl ester;
monochlorobenzenes;
thienopyridine		anticoagulant;
P2Y12 receptor antagonist;
platelet aggregation inhibitor
carfentanil[no description available]low00methyl ester;
piperidines;
tertiary amino compound;
tertiary carboxamide		mu-opioid receptor agonist;
opioid analgesic;
tranquilizing drug
leucine methyl ester[no description available]low00alpha-amino acid ester;
L-leucine derivative;
methyl ester
npk 1886[no description available]low00dihydropyridine;
isopropyl ester;
methyl ester
tyrosine methyl ester[no description available]low00L-tyrosyl ester;
methyl ester
tetrahydroalstonine[no description available]low00methyl ester;
organic heteropentacyclic compound;
yohimban alkaloid		plant metabolite
methyl 3-aminopyrazine-2-carboxylate[no description available]low00aromatic amine;
methyl ester;
pyrazines
voacamine[no description available]low00alkaloid ester;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
plant metabolite
tetracenomycin c[no description available]low00methyl ester;
tertiary alpha-hydroxy ketone;
tetracenomycin
thifensulfuron methyl[no description available]low001,3,5-triazines;
methyl ester;
N-sulfonylurea;
thiophenes		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
methyl 3-(4-hydroxyphenyl)propionate[no description available]low00methyl ester;
phenols		nitrification inhibitor;
plant growth regulator
methyl methoxyacetate[no description available]low00methyl ester
picloram-methyl[no description available]low00aminopyridine;
chloropyridine;
methyl ester		herbicide
cloransulam-methyl[no description available]low00methyl ester;
monochlorobenzenes;
organofluorine compound;
sulfonamide;
triazolopyrimidines		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
loganin[no description available]low00beta-D-glucoside;
cyclopentapyran;
enoate ester;
iridoid monoterpenoid;
methyl ester;
monosaccharide derivative;
secondary alcohol		anti-inflammatory agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
EC 3.4.23.46 (memapsin 2) inhibitor;
neuroprotective agent;
plant metabolite
methyl 2-(((((4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl)benzoate[no description available]low00aromatic ether;
benzoate ester;
diamino-1,3,5-triazine;
methyl ester;
N-sulfonylurea		EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
triflusulfuron-methyl[no description available]low001,3,5-triazines;
aromatic ether;
benzoate ester;
methyl ester;
N-sulfonylurea;
organofluorine compound;
tertiary amino compound		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
proherbicide
rhodomycinone[no description available]low00carbopolycyclic compound;
methyl ester;
polyphenol;
tetracenequinones;
tetracenomycin
ecgonine methyl ester[no description available]low00methyl ester;
tertiary amino compound;
tropane alkaloid		analgesic;
central nervous system depressant;
metabolite;
mouse metabolite;
opioid analgesic;
peripheral nervous system drug
nimbin[no description available]low00acetate ester;
cyclic terpene ketone;
enone;
furans;
limonoid;
methyl ester;
tetracyclic triterpenoid		pesticide;
plant metabolite
kt 5823[no description available]low00gamma-lactam;
hemiaminal;
indolocarbazole;
methyl ester;
organic heterooctacyclic compound		EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor
lofentanil[no description available]low00methyl ester;
piperidines;
tertiary amino compound;
tertiary carboxamide		mu-opioid receptor agonist;
opioid analgesic
rubimaillin[no description available]low00benzochromene;
methyl ester;
phenols		acyl-CoA:cholesterol acyltransferase 2 inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
NF-kappaB inhibitor;
plant metabolite
aspartame[no description available]low00carboxylic acid;
dipeptide zwitterion;
dipeptide;
methyl ester		apoptosis inhibitor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
environmental contaminant;
micronutrient;
nutraceutical;
sweetening agent;
xenobiotic
aclacinomycin[no description available]low00aminoglycoside;
anthracycline;
deoxy hexoside;
methyl ester;
monosaccharide derivative;
phenols;
polyketide;
tertiary alcohol;
tetracenequinones;
zwitterion		antimicrobial agent;
antineoplastic agent;
metabolite
metsulfuron methyl[no description available]low00methoxy-1,3,5-triazine;
methyl ester;
N-sulfonylurea		herbicide
aklavinone[no description available]low00anthracycline;
methyl ester;
tertiary alcohol;
tetracenequinones		antineoplastic agent
guvacoline[no description available]low00alpha,beta-unsaturated carboxylic ester;
beta-amino acid ester;
enoate ester;
methyl ester;
pyridine alkaloid;
secondary amino compound;
tetrahydropyridine		muscarinic agonist;
plant metabolite
secologanin[no description available]low00aldehyde;
beta-D-glucoside;
enoate ester;
methyl ester;
pyrans;
secoiridoid glycoside		plant metabolite
strictosidine[no description available]low00alkaloid ester;
beta-D-glucoside;
indole alkaloid;
methyl ester
secoxyloganin[no description available]low00beta-D-glucoside;
dicarboxylic acid monoester;
enoate ester;
methyl ester;
monosaccharide derivative;
pyrans;
secoiridoid glycoside		anti-allergic agent;
antioxidant;
plant metabolite
bisdechlorogeodin[no description available]low001-benzofurans;
cyclohexadiene;
methyl ester;
oxaspiro compound		antimicrobial agent
vincaleukoblastine[no description available]low00acetate ester;
indole alkaloid fundamental parent;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
tertiary alcohol;
tertiary amino compound;
vinca alkaloid		antineoplastic agent;
immunosuppressive agent;
microtubule-destabilising agent;
plant metabolite
aricine[no description available]low00methyl ester;
yohimban alkaloid
methyl 3,4-dihydroxybenzoate[no description available]low00catechols;
methyl ester		antioxidant;
neuroprotective agent;
plant metabolite
aglafoline[no description available]low00methyl ester;
organic heterotricyclic compound		metabolite;
platelet aggregation inhibitor
raubasine[no description available]low00methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound		alpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent
eplerenone[no description available]low003-oxo-Delta(4) steroid;
epoxy steroid;
gamma-lactone;
methyl ester;
organic heteropentacyclic compound;
oxaspiro compound;
steroid acid ester		aldosterone antagonist;
antihypertensive agent
cocaine[no description available]low00benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
aclarubicin[no description available]low00aminoglycoside;
anthracycline;
methyl ester;
phenols;
polyketide;
tetracenequinones;
trisaccharide derivative;
zwitterion		antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
dimethyloxalylglycine[no description available]low00glycine derivative;
methyl ester;
secondary carboxamide		EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor;
neuroprotective agent
methyl indole-3-carboxylate[no description available]low00indoles;
methyl ester		metabolite
dimethyl fumarate[no description available]low00diester;
enoate ester;
methyl ester		antipsoriatic;
immunomodulator
3-(6-methyl-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)propanoic acid methyl ester[no description available]low00methyl ester;
pyrimidinethione;
pyrimidone
methyl caffeate[no description available]low00alkyl caffeate ester;
methyl ester
tosylarginine methyl ester[no description available]low00guanidines;
L-arginine ester;
methyl ester;
sulfonamide
alpha-acetyllysine methyl ester[no description available]low00acetamides;
alpha-amino acid ester;
L-lysine derivative;
methyl ester;
primary amino compound
azoxystrobin[no description available]low00aryloxypyrimidine;
enoate ester;
enol ether;
methoxyacrylate strobilurin antifungal agent;
methyl ester;
nitrile		antifungal agrochemical;
environmental contaminant;
mitochondrial cytochrome-bc1 complex inhibitor;
quinone outside inhibitor;
xenobiotic
sf 2370[no description available]low00bridged compound;
gamma-lactam;
methyl ester;
organic heterooctacyclic compound		antimicrobial agent;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
tropomyosin-related kinase B receptor antagonist
5-methoxycarbonylmethyluridine[no description available]low00methyl ester;
uridines
dimethyl maleate[no description available]low00diester;
maleate ester;
methyl ester
bryostatin 1[no description available]low00acetate ester;
bryostatins;
cyclic hemiketal;
enoate ester;
methyl ester;
organic heterotetracyclic compound;
secondary alcohol		alpha-secretase activator;
anti-HIV-1 agent;
antineoplastic agent;
marine metabolite;
protein kinase C agonist
rescinnamine[no description available]low00indole alkaloid;
methyl ester;
organic heteropentacyclic compound		antihypertensive agent
geissospermine[no description available]low00indole alkaloid;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound		EC 3.1.1.7 (acetylcholinesterase) inhibitor
oleuropein[no description available]low00beta-D-glucoside;
catechols;
diester;
methyl ester;
pyrans;
secoiridoid glycoside		anti-inflammatory agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
NF-kappaB inhibitor;
nutraceutical;
plant metabolite;
radical scavenger
l796778[no description available]low00benzenes;
C-nitro compound;
L-lysine derivative;
L-phenylalanine derivative;
methyl ester;
oligopeptide;
secondary carboxamide;
ureas		somatostatin receptor agonist
l803087[no description available]low00benzenes;
fluoroindole;
guanidines;
L-arginine derivative;
methyl ester;
phenylindole;
secondary carboxamide		somatostatin receptor agonist
vinorelbine[no description available]low00acetate ester;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
ring assembly;
vinca alkaloid		antineoplastic agent;
photosensitizing agent
methyl 2,5-dihydroxycinnamate[no description available]low00cinnamate ester;
hydroquinones;
methyl ester		EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
geroprotector;
human urinary metabolite;
plant metabolite
methyl ferulate[no description available]low00cinnamate ester;
guaiacols;
methyl ester		plant metabolite
monomethyl fumarate[no description available]low00dicarboxylic acid monoester;
enoate ester;
methyl ester		antioxidant;
drug metabolite;
immunomodulator
catharanthine[no description available]low00alkaloid ester;
bridged compound;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound
thermorubin[no description available]low00dicarboxylic acid monoester;
methyl ester;
naphthoisochromene
cystothiazole a[no description available]low001,3-thiazoles;
biaryl;
enoate ester;
enol ether;
methyl ester;
organonitrogen heterocyclic antibiotic		antifungal agent;
antineoplastic agent;
bacterial metabolite
methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone[no description available]low00alpha-chloroketone;
methyl ester;
tripeptide		EC 3.4.21.37 (leukocyte elastase) inhibitor
kresoxim-methyl[no description available]low00aromatic ether;
methoxyiminoacetate strobilurin antifungal agent;
methyl ester;
oxime O-ether		antifungal agrochemical;
environmental contaminant;
mitochondrial cytochrome-bc1 complex inhibitor;
xenobiotic
coronardine[no description available]low00alkaloid ester;
methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound		antileishmanial agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite
salannin[no description available]low00acetate ester;
furans;
limonoid;
methyl ester;
organic heteropentacyclic compound		antifeedant;
insect growth regulator;
plant metabolite
bryostatin 2[no description available]low00bryostatins;
cyclic hemiketal;
enoate ester;
methyl ester;
organic heterotetracyclic compound;
secondary alcohol		antineoplastic agent;
marine metabolite;
protein kinase C agonist
n(3)-(4-methoxyfumaroyl)-2,3-diaminopropionic acid[no description available]low00enoate ester;
methyl ester;
monocarboxylic acid amide		metabolite
varespladib methyl[no description available]low00aromatic ether;
benzenes;
indoles;
methyl ester;
primary carboxamide		anti-inflammatory drug;
antidote;
EC 3.1.1.4 (phospholipase A2) inhibitor;
prodrug
estin[no description available]low001-benzofurans;
ether;
methyl ester;
organochlorine compound;
oxaspiro compound;
phenols		Aspergillus metabolite;
Penicillium metabolite
nidulalin a[no description available]low00methyl ester;
phenols;
xanthones		antimicrobial agent;
antineoplastic agent;
Penicillium metabolite
fluacrypyrim[no description available]low00enoate ester;
enol ether;
methyl ester;
organofluorine acaricide;
pyrimidines		mitochondrial cytochrome-bc1 complex inhibitor
elloramycin[no description available]low00alpha-L-rhamnoside;
carboxylic ester;
enol ether;
enone;
methyl ester;
monosaccharide derivative;
phenols;
tertiary alpha-hydroxy ketone;
tetracenomycin		antimicrobial agent;
bacterial metabolite
akuammicine[no description available]low00methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		plant metabolite
6-deacetylnimbin[no description available]low00cyclic terpene ketone;
diester;
enone;
furans;
limonoid;
methyl ester;
tetracyclic triterpenoid		antifeedant;
insect growth regulator;
plant metabolite
vinflunine[no description available]low00acetate ester;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
semisynthetic derivative;
vinca alkaloid		antineoplastic agent
quinine[no description available]low00Aspidosperma alkaloid;
epoxide;
methyl ester;
monoterpenoid indole alkaloid;
organic heterohexacyclic compound		plant metabolite
episilvestrol[no description available]low00dioxanes;
ether;
methyl ester;
organic heterotricyclic compound		antineoplastic agent;
metabolite
trifloxystrobin[no description available]low00methoxyiminoacetate strobilurin antifungal agent;
methyl ester;
organofluorine compound;
oxime O-ether		antifungal agrochemical;
mitochondrial cytochrome-bc1 complex inhibitor
silvestrol[no description available]low00dioxanes;
ether;
methyl ester;
organic heterotricyclic compound		antineoplastic agent;
metabolite
bacteriochlorophylls[no description available]low00bacteriochlorophyll;
methyl ester
methylamphotericin b[no description available]low00macrolide;
methyl ester;
monosaccharide derivative		antifungal agent;
antiinfective agent;
metabolite
wyosine[no description available]low00carbamate ester;
methyl ester;
nucleoside analogue
ligstroside[no description available]low00beta-D-glucoside;
diester;
methyl ester;
phenols;
pyrans;
secoiridoid glycoside		antineoplastic agent;
plant metabolite
kt 5926[no description available]low00gamma-lactam;
hemiaminal;
indolocarbazole;
methyl ester;
organic heterooctacyclic compound;
tertiary alcohol		EC 2.7.11.18 (myosin-light-chain kinase) inhibitor
chlorophyll a[no description available]low00chlorophyll;
methyl ester		cofactor
berkeleydione[no description available]low00beta-diketone;
cyclic terpene ketone;
meroterpenoid;
methyl ester;
organic heterotetracyclic compound;
terpene lactone;
tertiary alcohol;
tertiary alpha-hydroxy ketone		antineoplastic agent;
cysteine protease inhibitor;
Penicillium metabolite
berkeleytrione[no description available]low00beta-diketone;
carbopolycyclic compound;
cyclic terpene ketone;
meroterpenoid;
methyl ester;
tertiary alcohol;
tertiary alpha-hydroxy ketone		cysteine protease inhibitor;
Penicillium metabolite
vindolinine[no description available]low00methyl ester;
monoterpenoid indole alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		plant metabolite
picrinine[no description available]low00alkaloid ester;
indole alkaloid;
methyl ester;
organic heteropentacyclic compound;
polycyclic ether		analgesic;
anti-asthmatic agent;
anti-inflammatory agent;
antitussive;
plant metabolite
gardenoside[no description available]low00beta-D-glucoside;
cyclopentapyran;
enoate ester;
methyl ester;
monosaccharide derivative;
tertiary alcohol		metabolite
oleuropein aglycone[no description available]low00catechols;
diester;
lactol;
methyl ester;
pyrans;
secoiridoid		anti-inflammatory agent;
antioxidant;
mTOR inhibitor;
neuroprotective agent;
plant metabolite;
TRPA1 channel agonist
stemmadenine[no description available]low00Aspidosperma alkaloid;
methyl ester;
monoterpenoid indole alkaloid;
organic heterotetracyclic compound;
primary alcohol		plant metabolite
MS-417[no description available]low00methyl ester;
monochlorobenzenes;
thienotriazolodiazepine
leukotriene c4 monomethyl ester[no description available]low00leukotriene;
methyl ester
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure0low10
Absence Seizures0low10
Acute Kidney Failure0low20
Acute Kidney Injury0low20
Acute Kidney Insufficiency0low20
Acute Renal Failure0low20
Acute Renal Injury0low20
Acute Renal Insufficiency0low20
Allergic Contact Dermatitis0medium11
Anasarca0low10
Atonic Absence Seizure0low10
Atonic Absence Seizures0low10
Atonic Seizure0low10
Atonic Seizures0low10
Cancer of the Tongue0low10
Cancer of Tongue0low10
Canine Diseases0medium43
Cardiac Death0low10
Cat Diseases0medium21
Clonic Seizure0low10
Clonic Seizures0low10
Complex Partial Seizure0low10
Complex Partial Seizures0low10
Convulsion0low10
Convulsion, Non-Epileptic0low10
Convulsions0low10
Convulsive Seizure0low10
Convulsive Seizures0low10
Cyanosis0low10
Death0low10
Dermatitis, Allergic Contact0medium11
Dermatitis, Allergic Eczematous0medium11
Dermatitis, Contact, Allergic0medium11
Determination of Death0low10
Disease Models, Animal0low10
Dog Diseases0medium43
Dropsy0low10
Drug Overdose0low10
Ectoparasitic Infestations0low20
Edema0low10
End Of Life0low10
End-Of-Life0low10
Epileptic Seizure0low10
Epileptic Seizures0low10
Feline Diseases0medium21
Flea Infestations0medium33
Generalized Absence Seizure0low10
Generalized Absence Seizures0low10
Generalized Tonic-Clonic Seizures0low10
Hepatitis B0low10
Hepatitis B Virus Infection0low10
Hydrops0low10
Infections, Plasmodium0low10
Insect Bites0low10
Insect Bites and Stings0low10
Insect Stings0low10
Jacksonian Seizure0low10
Kidney Failure, Acute0low20
Kidney Insufficiency, Acute0low20
Malaria0low10
Marsh Fever0low10
Methemoglobinemia0low70
Myoclonic Seizure0low10
Myoclonic Seizures0low10
Near-Death Experience0low10
Neoplasms, Tongue0low10
Non-Epileptic Seizure0low10
Non-Epileptic Seizures0low10
Nonepileptic Seizure0low10
Nonepileptic Seizures0low10
Paludism0low10
Partial Seizure0low10
Partial Seizures0low10
Petit Mal Convulsion0low10
Plasmodium Infections0low10
Poisoning0low20
Remittent Fever0low10
Renal Failure, Acute0low20
Renal Insufficiency, Acute0low20
Rhabdomyolysis0low10
Seizure0low10
Seizures0low10
Seizures, Auditory0low10
Seizures, Clonic0low10
Seizures, Convulsive0low10
Seizures, Epileptic0low10
Seizures, Focal0low10
Seizures, Generalized0low10
Seizures, Gustatory0low10
Seizures, Motor0low10
Seizures, Olfactory0low10
Seizures, Sensory0low10
Seizures, Somatosensory0low10
Seizures, Tonic0low10
Seizures, Tonic-Clonic0low10
Seizures, Vertiginous0low10
Seizures, Vestibular0low10
Seizures, Visual0low10
Single Seizure0low10
Tongue Cancer0low10
Tongue Neoplasms0low10
Tonic Clonic Seizure0low10
Tonic Seizure0low10
Tonic Seizures0low10
Tonic-Clonic Seizure0low10
Tonic-Clonic Seizures0low10

Research Highlights

Safety/Toxicity (21)

ArticleYear
Metabolomics and mass spectrometry imaging reveal the chronic toxicity of indoxacarb to adult zebrafish (Danio rerio) livers.
Journal of hazardous materials, 07-05, Volume: 453		2023
Control efficacy and joint toxicity of metaflumizone mixed with chlorantraniliprole or indoxacarb against the fall armyworm, Spodoptera frugiperda.
Pest management science, Volume: 79, Issue: 3		2023
Carboxylated β-cyclodextrin anchored hollow mesoporous silica enhances insecticidal activity and reduces the toxicity of indoxacarb.
Carbohydrate polymers, Aug-15, Volume: 266		2021
Acute and Chronic Toxicity of Indoxacarb in Two Populations of Plutella xylostella (Lepidoptera: Plutellidae).
Journal of economic entomology, 02-09, Volume: 114, Issue: 1		2021
Influence of multi-walled carbon nanotubes on enantioselective bioaccumulation and oxidative stress toxicity of indoxacarb in zebrafish(Danio rerio).
Chemosphere, Volume: 267		2021
Effects of multi-walled carbon nanotubes on the enantioselective toxicity of the chiral insecticide indoxacarb toward zebrafish (Danio rerio).
Journal of hazardous materials, 10-05, Volume: 397		2020
Effect of Treatment With 3-Octylthio-1,1,1-Trifluoropropan-2-One in the Diamondback Moth (Lepidoptera: Plutellidae) to the Toxicity of Diafenthiuron, Indoxacarb, and Bacillus thuringiensis.
Journal of economic entomology, 06-06, Volume: 113, Issue: 3		2020
Assessing the combined toxicity of conventional and newer insecticides on the cotton mealybug Phenacoccus solenopsis.
Ecotoxicology (London, England), Volume: 26, Issue: 9		2017
Insecticide toxicity to the borer Neoleucinodes elegantalis (Guenée) (Lepidoptera: Crambidae): developmental and egg-laying effects.
Neotropical entomology, Volume: 47, Issue: 2		2018
Toxicity of nine insecticides on four natural enemies of Spodoptera exigua.
Scientific reports, 12-13, Volume: 6		2016
Toxic effects of indoxacarb enantiomers on the embryonic development and induction of apoptosis in zebrafish larvae (Danio rerio).
Environmental toxicology, Volume: 32, Issue: 1		2017
Baseline toxicity of metaflumizone and lack of cross resistance between indoxacarb and metaflumizone in diamondback moth (Lepidoptera: Plutellidae).
Journal of economic entomology, Volume: 106, Issue: 3		2013
Embryotoxicity and teratogenicity of pesticide indoxacarb to sea urchin (Strongylocentrotus intermedius).
Water science and technology : a journal of the International Association on Water Pollution Research, Volume: 61, Issue: 11		2010
Topical, residual and ovicidal contact toxicity of three reduced-risk insecticides against the European corn borer, Ostrinia nubilalis (Lepidoptera: Crambidae), on potato.
Pest management science, Volume: 63, Issue: 12		2007
Speed of efficacy and delayed toxicity characteristics of fast-acting fire ant (Hymenoptera: Formicidae) baits.
Journal of economic entomology, Volume: 99, Issue: 5		2006
Toxicity of indoxacarb and spinosad to the multicolored Asian lady beetle, Harmonia axyridis (Coleoptera: Coccinellidae), via three routes of exposure.
Pest management science, Volume: 62, Issue: 9		2006
IPM-compatibility of foliar insecticides for citrus: indices derived from toxicity to beneficial insects from four orders.
Journal of insect science (Online), Volume: 3		2003
The contact toxicity of indoxacarb and five other insecticides to Orius insidiosus (Hemiptera: Anthocoridae) and Aphidius colemani (Hymenoptera: Braconidae), beneficials used in the greenhouse industry.
Pest management science, Volume: 60, Issue: 12		2004
Toxicity of indoxacarb to two species of predacious mites and a predacious mirid.
Pest management science, Volume: 60, Issue: 5		2004
Toxicity, persistence, and efficacy of indoxacarb on cabbage looper (Lepidoptera: Noctuidae) on cabbage.
Journal of economic entomology, Volume: 95, Issue: 2		2002
Toxicity of a formulation of the insecticide indoxacarb to the tarnished plant bug, Lygus lineolaris (Hemiptera: Miridae), and the big-eyed bug, Geocoris punctipes (Hemiptera: Lygaeidae).
Pest management science, Volume: 58, Issue: 1		2002
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (1)

ArticleYear
Dissipation behavior, residue transfer, and safety evaluation of chlorantraniliprole and indoxacarb during tea growing and brewing by ultrahigh-performance liquid chromatography-tandem mass spectrometry.
Environmental science and pollution research international, Volume: 29, Issue: 42		2022
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
Bioavailability of chlorantraniliprole and indoxacarb to eastern subterranean termites (Isoptera: Rhinotermitidae) in various soils.
Journal of economic entomology, Volume: 102, Issue: 5		2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (13)

ArticleYear
Dissipation behavior, residue transfer, and safety evaluation of chlorantraniliprole and indoxacarb during tea growing and brewing by ultrahigh-performance liquid chromatography-tandem mass spectrometry.
Environmental science and pollution research international, Volume: 29, Issue: 42		2022
Insecticide resistance in Australian Spodoptera frugiperda (J.E. Smith) and development of testing procedures for resistance surveillance.
PloS one, Volume: 17, Issue: 2		2022
Western corn rootworm pyrethroid resistance confirmed by aerial application simulations of commercial insecticides.
Scientific reports, 04-30, Volume: 9, Issue: 1		2019
Baseline Susceptibility of Helicoverpa armigera (Lepidoptera: Noctuidae) to Indoxacarb, Emamectin Benzoate, and Chlorantraniliprole in Australia.
Journal of economic entomology, Volume: 108, Issue: 1		2015
A new class of insecticide for malaria vector control: evaluation of mosquito nets treated singly with indoxacarb (oxadiazine) or with a pyrethroid mixture against Anopheles gambiae and Culex quinquefasciatus.
Malaria journal, Sep-17, Volume: 14		2015
Linear-dendritic copolymers/indoxacarb supramolecular systems: biodegradable and efficient nano-pesticides.
Environmental science. Processes & impacts, Volume: 16, Issue: 10		2014
Estimation of indoxacarb residues by QuEChERS technique and its degradation pattern in cabbage.
Bulletin of environmental contamination and toxicology, Volume: 88, Issue: 3		2012
Esterase-mediated resistance to pyrethroids in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) from Central Africa.
Pest management science, Volume: 65, Issue: 10		2009
Emamectin benzoate: new insecticide against Helicoverpa armigera.
Communications in agricultural and applied biological sciences, Volume: 73, Issue: 3		2008
Evaluation of indoxacarb, an oxadiazine insecticide for the control of pyrethroid-resistant Anopheles gambiae (Diptera: Culicidae).
Journal of medical entomology, Volume: 44, Issue: 2		2007
Transfer of indoxacarb among workers of Coptotermes formosanus (Isoptera: Rhinotermitidae): effects of dose, donor:recipient ratio and post-exposure time.
Pest management science, Volume: 61, Issue: 12		2005
The contact toxicity of indoxacarb and five other insecticides to Orius insidiosus (Hemiptera: Anthocoridae) and Aphidius colemani (Hymenoptera: Braconidae), beneficials used in the greenhouse industry.
Pest management science, Volume: 60, Issue: 12		2004
Resistance and cross-resistance to four insecticides in populations of obliquebanded leafroller (Lepidoptera: Tortricidae).
Journal of economic entomology, Volume: 95, Issue: 4		2002
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
Effects of endosulfan, thiamethoxam, and indoxacarb in combination with atrazine on multi-biomarkers in Gammarus kischineffensis.
Ecotoxicology and environmental safety, Volume: 147		2018
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Natural Sources (1)

ArticleYear
Integrated pest management approach for a new pest, Lacanobia subjuncta (Lepidoptera: Noctuidae), in Washington apple orchards.
Pest management science, Volume: 60, Issue: 10		2004
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]