An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of methylsterol monooxygenase (EC 1.14.13.72).
ChEBI ID: 83316
| Member | Definition | Class |
|---|---|---|
| n-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide | An aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol. | fenhexamid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 18 (38.30) | 29.6817 |
| 2010's | 25 (53.19) | 24.3611 |
| 2020's | 4 (8.51) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (2.08%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 47 (97.92%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 40.7376 | 7 | 7 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 53.5673 | 6 | 6 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 24.3365 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 62.6224 | 5 | 5 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 27.4708 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 28.7092 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 43.6412 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 76.9588 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 33.6300 | 4 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 2.4337 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 34.7250 | 2 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 27.3060 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 68.5896 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 50.1448 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.0616 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 76.9588 | 1 | 1 |