Leukemia, Plasma Cell

A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.

Synonym
Leukemia, Plasma Cell

Excerpt	Reference
"Primary IgA plasma cell leukemia is a rare disorder in which hyperviscosity has not been reported."	( Gale, RP; Kosmo, MA, 1988)
"Three patients with plasma cell leukemia are reported."	( Cochi, S; De Laurenzi, A; Ferraro, P; Pacilli, L, 1983)
"Plasma cell leukemia is a rare disorder with poor prognosis."	( Arai, T; Fukutoku, M; Hirose, Y; Konda, S; Masaki, Y; Shimizu, S; Sugai, S; Takeshita, S; Takiguti, T; Yoshioka, R, 1994)
"Plasma cell leukemia is a rare malignant plasma cell disorder characterized by proliferation of plasma cells in blood and the bone marrow, the outcome of which is poor with conventional therapy."	( Cho, Y; Kim, BS; Kim, J; Kim, SJ; Seo, BK, 2007)
"Plasma cell leukemia is a rare hematological malignancy with a poor prognosis."	( Hosono, N; Nakamura, T; Ueda, T; Yamashita, T; Yamauchi, T, 2008)
"Plasma cell leukemia is a rare, aggressive form of multiple myeloma."	( Ambaliya, A; Dosi, RV; Joshi, HJ; Patell, RD, 2010)
"Plasma cell leukemia is a rare yet aggressive form of multiple myeloma characterized by high levels of plasma cells circulating in the peripheral blood."	( Abe, O; Ikemura, M; Kurokawa, M; Maki, H; Masamoto, Y; Miwa, A; Morita, K; Nakazaki-Watadani, K; Obo, T; Sumida, Y; Takami, H; Takayanagi, S; Tanaka, S; Yasaka, K, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	78 (28.06)	23.3326
1990's	40 (14.39)	12.5806
2000's	69 (24.82)	18.1394
2010's	60 (21.58)	28.8240
2020's	31 (11.15)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	4	0
choline	low	1	0
histamine	low	1	0
phytic acid	low	1	0
sulfites	low	2	0
uric acid	low	2	0
metrizoate	low	1	0
chlorambucil	low	3	0
deferoxamine	low	1	0
gentamicin	low	1	0
hydroxyurea	low	2	0
ifosfamide	low	1	0
indomethacin	low	1	0
mitoxantrone	low	2	0
pd 98059	low	1	0
pentoxifylline	low	1	0
phenylbutazone	low	1	0
potassium chloride	low	1	0
procarbazine	low	1	0
temozolomide	low	1	0
thalidomide	medium	43	2
urethane	low	2	0
mitomycin	low	1	0
prednisolone	low	24	0
thymidine	low	10	0
prednisone	low	32	0
chloramphenicol	low	1	0
uridine	low	1	0
kanamycin a	low	1	0
edetic acid	low	1	0
leucine	low	4	0
colchicine	low	1	0
egtazic acid	low	1	0
ampicillin	low	2	0
medroxyprogesterone acetate	low	1	0
valine	low	1	0
threonine	low	1	0
methylprednisolone	low	2	0
pyrazines	low	37	0
dexamethasone 21-phosphate	low	1	0
azacitidine	low	1	0
megestrol acetate	low	1	0
ethamsylate	low	1	0
fluorescein-5-isothiocyanate	low	1	0
vidarabine	low	2	0
technetium	low	1	0
thorium	low	3	0
tetradecanoylphorbol acetate	low	2	0
danazol	low	1	0
daunorubicin	low	3	0
amoxicillin	low	1	0
ribavirin	low	1	0
ng-nitroarginine methyl ester	low	1	0
vindesine	low	1	0
ibandronic acid	low	1	0
metaperiodate	low	1	0
triazoles	low	1	0
fluorodeoxyglucose f18	low	1	0
zoledronic acid	low	3	0
voriconazole	low	1	0
mizoribine	low	1	0
sr141716	low	1	0
pixantrone	low	1	0
sb 203580	low	1	0
glycogen	low	1	0
tretinoin	low	1	0
dactinomycin	low	3	0
l 743,872	low	1	0
dipyrone	low	1	0
fludarabine	low	2	0
mercaptopurine	low	1	0
thioguanine anhydrous	low	1	0
D-fructopyranose	low	1	0
u 0126	low	1	0
tetramethylrhodamine isothiocyanate	low	1	0
anandamide	low	1	0
barium	low	1	0
am-356	low	1	0
radium	low	2	0
thorium x	low	2	0
staurosporine	low	1	0
losartan potassium	low	2	0
acid phosphatase	low	3	0
cellulose	low	1	0
sodium bisulfite	low	2	0
lymphoprep	low	1	0
arginine	low	1	0
piperidines	low	1	0
abt-199	low	9	0
epidermal growth factor	low	2	0
transforming growth factor beta	low	2	0
agar	low	2	0
cyclin d1	low	6	0
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	low	1	0
muramidase	low	2	0
folic acid	low	1	0
dacarbazine	low	1	0
allopurinol	low	3	0
concanavalin a	low	1	0

Protein Targets (1,464)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
EWS/FLI fusion protein	31	0	0	31
Apoptosis regulator Bcl-2	0	3	2	5
Spike glycoprotein	23	0	1	24
Bcl-2-like protein 1	0	3	0	3
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Bcl-2-related protein A1	0	1	0	1
Bcl-2-like protein 2	0	1	0	1
Bcl2-associated agonist of cell death	0	1	0	1
interleukin 8	10	0	0	10
TDP1 protein	38	0	0	38
AR protein	40	0	0	40
thyroid stimulating hormone receptor	13	0	0	13
estrogen receptor 2 (ER beta)	18	0	0	18
progesterone receptor	23	0	0	23
glucocorticoid receptor [Homo sapiens]	29	0	0	29
estrogen-related nuclear receptor alpha	38	0	0	38
estrogen nuclear receptor alpha	43	0	0	43
IDH1	12	0	0	12
euchromatic histone-lysine N-methyltransferase 2	34	0	0	34
Bloom syndrome protein isoform 1	17	0	0	17
transcriptional regulator ERG isoform 3	5	0	0	5
thyroid hormone receptor beta isoform 2	29	0	0	29
ras-related protein Rab-9A	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	30	0	0	30
geminin	31	0	0	31
survival motor neuron protein isoform d	17	0	0	17
lamin isoform A-delta10	23	0	0	23
ATP-binding cassette sub-family C member 3	0	33	0	33
Multidrug resistance-associated protein 4	0	34	0	36
Polyphenol oxidase 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	22	0	0	22
Bile salt export pump	0	39	0	39
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	3
Cellular tumor antigen p53	35	0	0	35
Glutamate receptor 2	22	0	1	23
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	4	1	5
Xanthine dehydrogenase/oxidase	0	3	0	3
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	2	2
TAR DNA-binding protein 43	4	1	0	5
Canalicular multispecific organic anion transporter 1	0	33	0	34
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	2	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	24	0	0	24
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
Chain A, Ferritin light chain	10	0	0	10
phosphopantetheinyl transferase	12	0	0	12
aldehyde dehydrogenase 1 family, member A1	27	0	0	27
vitamin D3 receptor isoform VDRA	15	0	0	15
thyroid hormone receptor beta isoform a	10	0	0	10
DNA polymerase kappa isoform 1	12	0	0	12
Potassium channel subfamily K member 3	0	2	0	2
Cannabinoid receptor 1	0	5	3	8
Cannabinoid receptor 2	0	4	1	9
Cannabinoid receptor 2	0	2	1	3
Fatty-acid amide hydrolase 1	0	2	0	4
Cannabinoid receptor 2	0	2	0	2
Chain A, Beta-lactamase	11	0	0	11
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	8	0	0	8
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	18	0	0	18
urokinase-type plasminogen activator precursor	14	0	0	14
plasminogen precursor	14	0	0	14
urokinase plasminogen activator surface receptor precursor	14	0	0	14
Bile salt export pump	0	4	0	4
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	9	1	10
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	2
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	4	0	4
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Cruzipain	6	0	0	6
Beta-lactamase	0	0	0	1
acid sphingomyelinase	3	0	0	3
GLS protein	12	0	0	12
GLI family zinc finger 3	29	0	0	29
retinoic acid nuclear receptor alpha variant 1	33	0	0	33
farnesoid X nuclear receptor	24	0	0	24
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
chromobox protein homolog 1	15	0	0	15
DNA polymerase beta	4	0	0	4
Carbonic anhydrase 1	0	8	0	9
Carbonic anhydrase 2	0	9	1	13
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	1	2	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	2
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	1	0	2
ATP-dependent phosphofructokinase	17	0	0	17
Fatty-acid amide hydrolase 1	0	2	0	2
Fatty-acid amide hydrolase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Fatty acid-binding protein, liver	0	2	0	2
Glutamate receptor 1	1	0	1	2
Glutamate receptor 3	1	0	1	2
Glutamate receptor 4	1	0	1	2
Cannabinoid receptor 1	0	3	2	10
Alpha-1A adrenergic receptor	0	8	0	8
Cannabinoid receptor 1	0	3	1	4
Histamine H2 receptor	10	1	1	12
Fatty acid-binding protein 5	0	0	1	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	0	1	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
glp-1 receptor, partial	8	0	0	8
pregnane X receptor	8	0	0	8
RAR-related orphan receptor gamma	26	0	0	26
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	13	0	0	13
NFKB1 protein, partial	5	0	0	5
PPM1D protein	11	0	0	11
Thrombopoietin	6	0	0	6
Smad3	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	28	0	0	28
cytochrome P450 family 3 subfamily A polypeptide 4	28	0	0	28
retinoid X nuclear receptor alpha	28	0	0	28
pregnane X nuclear receptor	28	0	0	28
polyprotein	13	0	0	13
67.9K protein	12	0	0	12
Parkin	7	0	0	7
peroxisome proliferator-activated receptor delta	19	0	0	19
peroxisome proliferator activated receptor gamma	24	0	0	24
vitamin D (1,25- dihydroxyvitamin D3) receptor	24	0	0	24
arylsulfatase A	10	0	0	10
aryl hydrocarbon receptor	14	0	0	14
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	23	0	0	23
thyroid stimulating hormone receptor	9	0	0	9
activating transcription factor 6	14	0	0	14
peripheral myelin protein 22 isoform 1	9	0	0	9
hemoglobin subunit beta	3	0	0	3
cellular tumor antigen p53 isoform a	8	0	0	8
huntingtin isoform 2	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
peripheral myelin protein 22	15	0	0	15
histone acetyltransferase KAT2A isoform 1	11	0	0	11
muscarinic acetylcholine receptor M1	9	0	0	9
Interferon beta	26	0	0	26
Integrin beta-3	7	0	0	7
Integrin alpha-IIb	7	0	0	7
Adenosine receptor A3	0	8	0	8
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Adenosine receptor A1	0	4	0	4
D(1A) dopamine receptor	2	0	0	2
Nuclear receptor ROR-gamma	10	1	1	12
Multidrug and toxin extrusion protein 1	0	3	0	3
Histone-lysine N-methyltransferase EHMT2	0	2	0	2
ATPase family AAA domain-containing protein 5	19	0	0	19
Ataxin-2	23	0	0	23
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	2	0	2
caspase 7, apoptosis-related cysteine protease	9	0	0	9
caspase-3	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	9	0	0	9
Histone H2A.x	17	0	0	17
Caspase-7	7	0	0	7
caspase-3	7	0	0	7
heat shock protein beta-1	9	0	0	9
26S proteasome non-ATPase regulatory subunit 11	0	2	0	2
26S proteasome non-ATPase regulatory subunit 12	0	2	0	2
26S proteasome non-ATPase regulatory subunit 14	0	2	0	2
Proteasome subunit alpha type-7	0	2	0	2
Histone deacetylase 3	0	7	2	12
26S proteasome non-ATPase regulatory subunit 3	0	2	0	2
Carbonic anhydrase 12	0	4	0	5
Prothrombin	0	1	0	2
Chymotrypsinogen A	0	1	0	1
Carbonic anhydrase 3	0	1	0	2
Cathepsin B	0	2	0	2
Neutrophil elastase	0	3	0	3
Cathepsin G	0	3	0	3
Lysosomal protective protein	0	2	0	2
Chymotrypsinogen B	0	2	0	2
26S proteasome regulatory subunit 6A	0	2	0	2
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	3
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase 6	0	1	0	2
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	2	0	2
Proteasome subunit alpha type-2	0	2	0	2
Proteasome subunit alpha type-3	0	2	0	2
Proteasome subunit alpha type-4	0	2	0	2
Proteasome subunit beta type-8	0	2	0	2
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	2	0	2
Proteasome subunit alpha type-5	0	2	0	2
Proteasome subunit beta type-4	0	2	0	2
Proteasome subunit beta type-6	0	2	0	2
Proteasome subunit beta type-5	0	4	0	5
Carbonic anhydrase 5A, mitochondrial	0	4	0	5
26S proteasome regulatory subunit 7	0	2	0	2
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	2	0	2
Carbonic anhydrase 7	0	1	0	2
26S proteasome regulatory subunit 6B	0	2	0	2
26S proteasome non-ATPase regulatory subunit 8	0	2	0	2
Proteasome subunit beta type-3	0	2	0	2
Proteasome subunit beta type-2	0	2	0	3
26S proteasome non-ATPase regulatory subunit 7	0	2	0	2
26S proteasome non-ATPase regulatory subunit 4	0	2	0	2
26S proteasome complex subunit SEM1	0	2	0	2
Proteasome subunit alpha type-6	0	2	0	2
26S proteasome regulatory subunit 4	0	2	0	2
26S proteasome regulatory subunit 8	0	2	0	2
26S proteasome regulatory subunit 10B	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	2	0	2
Histone deacetylase 1	0	8	3	14
26S proteasome non-ATPase regulatory subunit 6	0	2	0	2
Proteasomal ubiquitin receptor ADRM1	0	2	0	2
Carbonic anhydrase 9	0	7	0	9
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	1	0	2
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	2	0	2
Histone deacetylase 2	0	7	3	13
Proteasome subunit beta type-7	0	2	0	2
26S proteasome non-ATPase regulatory subunit 1	0	2	0	2
Carbonic anhydrase 15	0	1	0	2
Histone deacetylase 8	0	8	2	13
Histone deacetylase 6	0	8	3	14
Carbonic anhydrase 14	0	2	0	3
26S proteasome non-ATPase regulatory subunit 13	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
15-lipoxygenase, partial	10	0	0	10
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lethal factor (plasmid)	7	0	0	7
Matrix metalloproteinase-9	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
acetylcholinesterase	9	0	0	9
Proteasome subunit beta type-2	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
endonuclease IV	5	0	0	5
cytochrome P450 2D6	13	0	0	13
nuclear receptor ROR-gamma isoform 1	8	0	0	8
Glutathione reductase, mitochondrial	0	1	0	1
Alpha-synuclein	3	1	0	4
Glutathione reductase	0	1	0	1
Luciferase	11	0	0	11
thioredoxin reductase	13	0	0	13
GALC protein	3	0	0	3
Microtubule-associated protein tau	11	0	0	11
thioredoxin glutathione reductase	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
muscleblind-like protein 1 isoform 1	9	0	0	9
Cytochrome P450 2D6	0	4	2	6
Solute carrier organic anion transporter family member 1B3	0	8	0	9
G	16	0	0	16
streptokinase A precursor	0	0	1	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
HLA class I histocompatibility antigen, B alpha chain	16	0	0	16
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Cytochrome P450 3A4	0	8	1	11
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	16	0	0	16
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	16	0	0	16
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 1	0	1	0	3
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	3	0	3
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	2	0	4
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	2	0	4
PAX8	0	0	0	3
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
USP1 protein, partial	15	0	0	15
glucocerebrosidase	5	0	0	5
cytochrome P450 2D6 isoform 1	5	0	0	5
nuclear receptor subfamily 0 group B member 1	0	2	0	2
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	17	0	0	17
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
flap endonuclease 1	4	0	0	4
steroidogenic factor 1	0	2	0	2
cytochrome P450 3A4 isoform 1	12	0	0	12
caspase-1 isoform alpha precursor	3	0	0	3
neuropeptide S receptor isoform A	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	12	0	0	12
Solute carrier family 22 member 3	0	3	0	4
Tubulin alpha-1A chain	0	3	1	4
Tubulin beta chain	0	3	1	4
Plasma kallikrein	0	0	0	2
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	6	0	10
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	12	0	0	12
Gamma-aminobutyric acid receptor subunit delta	12	0	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-5	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	12	0	0	12
ATP-dependent translocase ABCB1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	12	0	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	12	0	0	12
Gamma-aminobutyric acid receptor subunit alpha-1	12	0	0	12
Gamma-aminobutyric acid receptor subunit beta-3	12	0	0	12
Gamma-aminobutyric acid receptor subunit beta-2	12	0	0	12
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	3	0	3
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
GABA theta subunit	12	0	0	12
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Gamma-aminobutyric acid receptor subunit epsilon	12	0	0	12
Tubulin beta-1 chain	0	2	2	5
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	3	0	6
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	3	0	5
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	2	0	3
E3 ubiquitin-protein ligase Mdm2	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
Inositol monophosphatase 1	6	0	0	6
Isocitrate lyase	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
RAD51	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	2	0	0	2
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	1	2
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	2	0	2
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
Rap guanine nucleotide exchange factor 3	3	0	0	3
Estrogen receptor	0	5	1	6
Glucocorticoid receptor	0	12	3	20
Sex hormone-binding globulin	0	0	2	2
Cytochrome P450 1A2	0	2	1	3
Glycine receptor subunit alpha-1	0	12	0	12
Aldo-keto reductase family 1 member B1	0	5	0	5
Alpha-2A adrenergic receptor	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Androgen receptor	0	10	0	10
Alpha-1B adrenergic receptor	0	7	0	7
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Glycine receptor subunit beta	0	12	0	12
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Glycine receptor subunit alpha-2	0	12	0	12
Sodium-dependent noradrenaline transporter	0	4	0	4
Glycine receptor subunit alpha-3	0	12	0	12
5-hydroxytryptamine receptor 2A	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
mitogen-activated protein kinase 1	6	0	0	6
Transthyretin	0	1	0	1
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	2	0	2
DNA topoisomerase 2-alpha	0	2	1	10
Carbonyl reductase [NADPH] 1	0	0	0	1
Platelet-activating factor receptor	1	0	0	1
Multidrug resistance-associated protein 1	0	5	0	7
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	4
Lysine-specific demethylase 4A	0	1	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	1	3	0	4
Angiotensin-converting enzyme	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
DNA topoisomerase 2	0	0	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	3
Glutamate receptor ionotropic, NMDA 2B	0	2	0	4
Glutamate receptor ionotropic, NMDA 2C	0	1	0	3
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	9
Glutamate receptor ionotropic, NMDA 2D	0	1	0	3
Integrase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	3
Glutamate receptor ionotropic, NMDA 3A	0	1	0	3
Sphingosine 1-phosphate receptor 1	0	0	1	1
RCG53912, isoform CRA_a	0	0	0	1
Sphingosine kinase 1	0	0	0	1
Sphingosine kinase 2	0	0	0	1
Sphingosine kinase 1	0	0	0	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	4	4
5'-nucleotidase	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine deaminase	0	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
alpha-galactosidase	3	0	0	3
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	2	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
regulator of G-protein signaling 4	10	0	0	10
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Histamine H2 receptor	0	3	2	5
Adenosine receptor A1	0	1	0	2
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	1	0	2
Histamine H1 receptor	0	1	4	5
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Histamine H1 receptor	0	2	2	4
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Histamine H3 receptor	0	1	2	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	3	0	4
Farnesyl pyrophosphate synthase	0	4	0	4
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Tyrosine-protein kinase ABL1	0	3	3	8
Cytochrome P450 2C8	0	1	0	2
Mast/stem cell growth factor receptor Kit	0	1	2	3
Breakpoint cluster region protein	0	0	1	3
Platelet-derived growth factor receptor alpha	0	1	2	3
Cytochrome P450 3A5	0	1	0	2
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
M-phase phosphoprotein 8	5	0	0	5
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	4	1	5
Phospholipase A2, major isoenzyme	0	1	0	1
Albumin	0	2	1	3
Prostaglandin G/H synthase 1	0	4	0	5
Procathepsin L	0	1	1	2
Interleukin-8	0	1	0	1
Androgen receptor	0	4	3	7
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	5	2	7
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	2	0	2
Aldo-keto reductase family 1 member C2	0	2	0	2
Prostaglandin D2 receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 6	0	1	0	3
Solute carrier family 22 member 7	0	0	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 8	0	3	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Cereblon isoform 4	0	4	0	4
Bromodomain-containing protein 4	0	3	0	3
DNA-binding protein Ikaros	0	0	2	7
DNA damage-binding protein 1	0	3	2	5
Protein cereblon	0	8	3	16
Zinc finger protein Aiolos	0	0	2	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	1	0	2
Phospholipase A-2-activating protein	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
PINK1	1	0	0	1
nonstructural protein 1	6	0	0	6
Progesterone receptor	0	4	1	6
Mineralocorticoid receptor	0	3	1	4
Androgen receptor	0	0	1	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Estrogen receptor beta	0	3	1	4
bioA	0	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	3	0	0	3
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Toll-like receptor 4	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	2	2
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
WRN	1	0	0	1
DNA polymerase III, partial	1	0	0	1
hypothetical protein, conserved	2	0	0	2
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
pyruvate kinase	2	0	0	2
phospholipase A2, group III	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
interferon gamma precursor	0	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
protein AF-9 isoform a	0	0	0	1
tyrosine-protein kinase Yes	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
Vpr	1	0	0	1
pyruvate kinase PKM isoform b	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	1	3
Tyrosine-protein kinase Fyn	0	1	1	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Proto-oncogene tyrosine-protein kinase ROS	0	1	1	2
Ornithine decarboxylase	2	0	0	3
Muscarinic acetylcholine receptor M1	0	4	0	4
Angiotensin-converting enzyme	0	2	0	2
Casein kinase II subunit alpha'	0	1	1	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Tyrosine-protein kinase BTK	0	1	1	2
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
Single-stranded DNA cytosine deaminase	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Collagenase 3	0	1	0	1
Histone deacetylase 8	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	1	2
Protein Tat	0	0	2	2
Leukotriene A-4 hydrolase	0	2	0	2
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	1	2
Histone deacetylase 4	0	6	1	10
NAD-dependent protein deacetylase sirtuin-2	0	2	0	2
Histone deacetylase 7	0	6	2	11
Polyamine deacetylase HDAC10	0	6	1	10
Histone deacetylase 11	0	6	1	10
NAD-dependent protein deacetylase sirtuin-1	0	2	0	2
NAD-dependent protein deacetylase sirtuin-7	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	2	0	2
Histone deacetylase 9	0	6	1	10
Histone deacetylase 5	0	6	1	10
Histone deacetylase	0	2	0	2
Nuclear receptor corepressor 2	0	3	0	3
RAF proto-oncogene serine/threonine-protein kinase	0	3	1	4
Luciferin 4-monooxygenase	0	1	1	2
Amine oxidase [flavin-containing] B	0	3	0	3
Mitogen-activated protein kinase 3	0	1	1	3
Mitogen-activated protein kinase 1	0	2	1	3
Dual specificity mitogen-activated protein kinase kinase 2	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	3	1	4
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Tumor necrosis factor	0	1	0	1
Cholinesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A2b	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, Beta-arrestin 1	0	0	1	1
Programmed cell death protein 1	0	1	0	1
E3 ubiquitin-protein ligase ZFP91	0	0	0	1
Programmed cell death 1 ligand 1	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
NS5	0	0	1	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Angiotensin-converting enzyme 2	0	0	1	1
Chain A, Erk2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Citron Rho-interacting kinase	0	1	1	2
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	1	1	2
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Mitogen-activated protein kinase 13	0	1	2	3
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 2	0	1	0	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	1	1	2
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	1	1	2
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	1	2	3
Cyclin-dependent kinase 14	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
High affinity nerve growth factor receptor	0	0	1	1
Protein kinase C gamma type	0	2	1	3
Myeloperoxidase	0	1	0	1
Protein kinase C beta type	0	2	1	3
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Tyrosinase	0	1	0	1
Fibroblast growth factor receptor 1	0	0	1	1
Cholesteryl ester transfer protein	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	2	1	3
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	2	1	3
cAMP-dependent protein kinase catalytic subunit alpha	0	1	1	2
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	1	2
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Protein kinase C eta type	0	1	2	3
Activin receptor type-2A	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	1	1	2
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
Sodium-dependent serotonin transporter	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	1	2
RAC-beta serine/threonine-protein kinase	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	4	1	5
Dual specificity protein kinase TTK	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 2	0	2	1	3
Receptor-type tyrosine-protein kinase FLT3	0	1	1	2
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	1	1	2
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Protein kinase C iota type	0	1	2	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	1	2
Serine/threonine-protein kinase mTOR	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	1	1	2
Tyrosine-protein kinase FRK	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Mitogen-activated protein kinase 14	0	1	1	2
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	1	1	2
MAP kinase-activated protein kinase 2	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Casein kinase I isoform epsilon	0	1	1	2
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 12	0	1	2	3
Mitogen-activated protein kinase 10	0	2	1	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Tubulin alpha-1A chain	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
Protein kinase C epsilon type	0	2	2	4
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Protein kinase C theta type	0	1	2	3
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	2	2	4
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	1	1	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Serine/threonine-protein kinase D1	0	1	2	3
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	1	2	3
Serine/threonine-protein kinase STK11	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	3	2	5
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
P2X purinoceptor 7	0	1	0	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	1	1	2
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
SRSF protein kinase 1	0	0	1	1
P2X purinoceptor 7	0	1	0	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	1	1	2
BMP-2-inducible protein kinase	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase NLK	0	1	1	2
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	1	1	2
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Orexin receptor type 1	0	0	0	1
Cathepsin B	0	1	0	1
Mu-type opioid receptor	0	1	0	1
N-arachidonyl glycine receptor	0	1	0	1
G-protein coupled bile acid receptor 1	0	1	0	1
G-protein coupled receptor 55	0	0	1	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
polyadenylate-binding protein 1	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
Ras guanyl-releasing protein 3	0	0	1	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
5-hydroxytryptamine receptor 1A	0	2	0	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Alpha-1D adrenergic receptor	0	2	0	2
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Malate dehydrogenase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Equilibrative nucleoside transporter 2	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Cytochrome P450 2B6	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Chain A, Histone deacetylase-like amidohydrolase	0	1	0	1
Nrf2	1	0	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
Gli1	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
protein Wnt-3a precursor	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Histone deacetylase 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Nuclear receptor corepressor 1	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	0	1
Aminopeptidase N	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Apoptosis regulator BAX	0	0	1	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase	0	1	0	1
Renin	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	1	3
Histone deacetylase	0	1	0	1
HD2 type histone deacetylase HDA106	0	2	0	2
Carboxypeptidase B2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
REST corepressor 3	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (278)

Protein Targets (1,464)

Leukemia, Plasma Cell

Synonyms(1)

Research Excerpts

Overview

Research

Studies (278)

Drugs Studied (128)

Protein Targets (1,464)