triazoles has been researched along with pyrimidinones in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (7.25) | 18.7374 |
| 1990's | 9 (13.04) | 18.2507 |
| 2000's | 7 (10.14) | 29.6817 |
| 2010's | 39 (56.52) | 24.3611 |
| 2020's | 9 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Aibara, S; Isoda, S; Kanno, H; Miwa, T; Ryokawa, Y; Suzuki, N; Takamori, H; Tsubokawa, M; Tsukada, W | 1 |
| Amrick, CL; Bennett, DA; Francis, JE; Hyun, JL; Loo, PS; Murphy, D; Neale, RF; Rovinski, SL; Wilson, DE | 1 |
| Catto, L; Jones, RB; Leonard, T; Poole, A; Pritchard, D | 2 |
| Kasztreiner, E; Kosary, J; Polos, K | 1 |
| Steele, MW; Vaughan, MH | 1 |
| Daly, MJ; Humphray, JM; Stables, R | 1 |
| Sung, WL | 1 |
| Ault, B; Bacon, ER; Kelly, MD; Krafte, D; Kraynak, M; Pennock, PO; Sawutz, D; Singh, B; Subramanyam, C; Treasurywala, A | 1 |
| Bormann, G; Hof, RP; Rüegg, UT; Salzmann, R; Zierhut, W | 1 |
| Gay, JC | 1 |
| Fujimura, M; Matsuda, T; Ogawa, H; Saito, M | 1 |
| Algueró, M; Bartroli, J; Boncompte, E; Conte, L; Forn, J; García-Rafanell, J; Merlos, M; Ramis, J; Turmo, E; Vericat, ML | 1 |
| Cho, R; Kapur, S; Kennedy, S; Meyer, JH | 1 |
| Eppinger, E; Meinhardt, G; Schmidmaier, R | 1 |
| Maldonado, CR; Quirós, M; Salas, JM | 1 |
| Laurence, J | 1 |
| Kuritzkes, DR | 1 |
| El-Bondkly, AM; El-Gendy, MM; Laatsch, H; Shaaban, KA; Shaaban, M | 1 |
| Chawla, PS; Kochar, MS | 1 |
| Borea, PA; Catarzi, D; Colotta, V; Filacchioni, G; Lenzi, O; Morizzo, E; Moro, S; Paoletta, S; Poli, D; Varani, K; Varano, F; Vincenzi, F | 1 |
| Bodade, RG; Dawane, BS; Khandare, NT; Khobragade, CN; Konda, SG | 1 |
| Darwish, MA; El-merzabani, MM; Shawali, AS; Sherif, SM | 1 |
| Liu, CJ; Wang, JD | 1 |
| Battaglia, U; Moody, CJ | 1 |
| Butler, MS; Cooper, MA; Huang, JX; Karoli, T; Ramu, S; Tee, EH | 1 |
| Chabchoub, F; Duval, R; Najahi, E; Nepveu, F; Sudor, J; Zribi, F | 1 |
| El-Nassan, HB | 1 |
| Barea, E; Caballero, AB; Marín, C; Ramírez-Macías, I; Rodríguez-Diéguez, A; Salas, JM; Sánchez-Moreno, M | 1 |
| Bararjanian, M; Dabiri, M; Koohshari, M; Movahed, SK; Salehi, P | 1 |
| Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX | 1 |
| Farghaly, TA; Hassaneen, HM | 1 |
| Acquaviva, J; Bates, RC; He, S; Jimenez, JP; Proia, DA; Sang, J; Sequeira, M; Smith, DL; Zhang, C | 1 |
| Edwards, NL; So, A | 1 |
| Kimura, I; Nishigori, K; Ono, M; Onoe, S; Saji, H; Sampei, S; Temma, T | 1 |
| Camarasa, MJ; Canela, MD; Delang, L; Gigante, A; Leyssen, P; Neyts, J; Pérez-Pérez, MJ; Priego, EM; Querat, G | 1 |
| Caballero, AB; Gutiérrez-Sánchez, R; Marín, C; Ramírez-Macías, I; Rodríguez-Diéguez, A; Salas, JM; Sánchez-Moreno, M; Santamaría-Díaz, N | 1 |
| Lubenov, LA; Mavrova, ATs; Tsenov, JA; Wesselinova, D | 1 |
| Ahmadi, F; Dabirian, S; Faizi, M; Shahhosseini, S; Tabatabai, SA; Tajali, H; Zavareh, ER | 1 |
| Diaz-Torné, C; Perez-Herrero, N; Perez-Ruiz, F | 1 |
| Buijsman, RC; de Man, J; de Roos, JA; de Vetter, JR; Prinsen, MB; Spijkers-Hagelstein, JA; Uitdehaag, JC; van Doornmalen, AM; Zaman, GJ | 1 |
| Niu, CW; Su, SW; Wu, Q; Xi, Z; Yang, GF; Zuo, Y | 1 |
| Espinoza-Vázquez, A; González-Olvera, R; Negrón-Silva, GE; Rodríguez-Gómez, FJ; Román-Rodríguez, V; Santillan, R | 1 |
| Arango, D; Chueh, AC; Dawson, MA; Dhillon, AS; Diez-Dacal, B; Filippakopoulos, P; Gahman, TC; Jayachandran, A; Mariadason, JM; Nightingale, R; Phesse, T; Shiau, AK; Sieber, OM; Tögel, L; Tran, H; Wu, R | 1 |
| Chang, M; Hesek, D; Lastochkin, E; Lee, M; Mobashery, S; Oliver, AG; Wang, H | 1 |
| Baillie, TA; Cyrus Khojasteh, S; Dalvie, D; Rietjens, IM | 1 |
| Aldhubiab, BE; Alwassil, OI; Attimarad, M; Bhandary, S; Chopra, D; Dharma Rao, GB; Harsha, S; Mlisana, K; Pillay, M; Venugopala, KN | 1 |
| Kanaho, Y; Miura, Y; Yamauchi, Y | 1 |
| Kaieda, A; Kanzaki, N; Kori, M; Kuno, H; Mototani, H; Naito, T; Nara, H; Oki, H; Santou, T; Sato, K; Terauchi, J; Uchikawa, O; Yamamoto, Y | 1 |
| Angus, SP; Beltran, AS; Bevill, SM; Carey, LA; Chen, X; Darr, DB; Duncan, JS; Earp, HS; Gallagher, K; Golitz, BT; Goulet, DR; Graves, LM; He, X; Johnson, GL; Olivares-Quintero, JF; Parker, JS; Perou, CM; Rashid, NU; Santos, C; Sciaky, N; Singh, D; Stuhlmiller, TJ; Velarde, SH; Whittle, MC; Zawistowski, JS | 1 |
| Bong Han, S; Ha, N; Jung, YS; Kim, C; Kim, HS; Kumar Biswas, B; Kwon, DH; Lee, CK; Malpani, YR; Soo Shin, J | 1 |
| Benabdi, S; Cañeque, T; Cherfils, J; Chikireddy, J; Dan, S; Nawrotek, A; Ohashi, Y; Peurois, F; Rodriguez, R; Shiina, I; Yamori, T; Zeghouf, M | 1 |
| Bin, W; Boo, ZZ; Fong, J; Givskov, M; Liu, XW; Nielsen, TE; Su, H; Tan, SK; Yang, L; Yang, R; Zhang, C | 1 |
| Appleton, BA; Balibar, CJ; Benton, BM; Blechschmidt, A; de Vicente, J; Drumm, JE; Feng, BY; Geng, M; Li, C; Lindvall, MK; Lingel, A; Lu, Y; Mamo, M; Mergo, W; Moreau, RJ; Polyakov, V; Skepper, CK; Smith, TM; Takeoka, K; Uehara, K; Wang, L; Wei, JR; Weiss, AH; Xie, L; Xu, W; Zhang, Q | 1 |
| Appleton, BA; Benton, BM; de Vicente, J; Drumm, JE; Feng, BY; Geng, M; Hu, C; Li, C; Lingel, A; Lu, Y; Mamo, M; Mergo, W; Moreau, RJ; Mostafavi, M; Rath, CM; Skepper, CK; Steffek, M; Takeoka, KT; Uehara, K; Wang, L; Wei, JR; Xie, L; Xu, W; Zhang, Q | 1 |
| Bartolozzi, A; Goble, SD; Guzman-Perez, A; Helal, CJ; Mani, NS; Ohri, AK; Shi, ZC; Subramanyam, C | 1 |
| Andrei, G; Curti, C; Kabri, Y; Kaoukabi, H; Lazrek, HB; Rodriguez-Ubis, JC; Snoeck, R; Taourirte, M; Vanelle, P | 1 |
| Allam, M; Babu, PP; Bhavani, AKD; Mudiraj, A; Ranjan, N; Thippana, M | 1 |
| Assiotis, I; Box, G; Chauhan, R; Cunningham, D; De Haven Brandon, A; Eason, K; Isacke, CM; Jenkins, L; Khan, K; Kirkin, V; Mancusi, C; Manodoro, F; Matthews, N; Robinson, P; Rust, AG; Sadanandam, A; Self, A; Starling, N; Valenti, M; Valeri, N; Vlachogiannis, G; Wagner, S; Whittaker, SR | 1 |
| Dosaka-Akita, H; Furuta, M; Kikuchi, E; Kikuchi, H; Kikuchi, J; Kinoshita, I; Konno, S; Maeda, M; Sakakibara-Konishi, J; Shoji, T; Suzuki, M; Takashima, Y | 1 |
| Ashour, HM; Fahmy, SM; Ibrahim, TM; Khalil, MA; Labouta, IM; Nassra, RA; Tageldin, GN | 1 |
| Li, H; Lu, A; Wang, Q; Wang, T; Wang, Z; Yang, S; Yao, Y | 1 |
| Adderley, T; Christopher, G; Irwin, MS; Kano, Y; Kee, L; Ladumor, Y; Ohh, M; Robinson, CM; Valencia-Sama, I | 1 |
| Arduino, RC; Bauch, T; Chen, M; Graviss, EA; Kimata, JT; Li, M; Liu, W; Wang, J | 1 |
| Carcaboso, AM; Diederichs, C; Gielen, GH; Hamdan, FH; Hulleman, E; Johnsen, SA; Kramm, CM; Kubiak, K; Nussbaumer, G; Wiese, M | 1 |
| Bathgate, RAD; Gong, GQ; Lin, G; Lin, L; Liu, Q; Wang, MW; Yang, D; Zhou, Q | 1 |
| Bergthaler, A; Bigenzahn, JW; César-Razquin, A; Kartnig, F; Kornauth, C; Lercher, A; Pemovska, T; Srndic, I; Staber, PB; Superti-Furga, G; Valent, P | 1 |
| Abd Al Moaty, MN; Abu-Serie, MM; Altowyan, MS; Awad, LF; Barakat, A; El Ashry, ESH; Ibrahim, NA; Teleb, M | 1 |
| Alcívar-León, CD; Cadena-Cruz, JE; Heredia-Moya, J; Zurita, DA | 1 |
7 review(s) available for triazoles and pyrimidinones
| Article | Year |
|---|---|
What's new in clinical pharmacology and therapeutics.
Topics: Abatacept; Acetanilides; Amides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antiparkinson Agents; Antirheumatic Agents; Antiviral Agents; Apomorphine; Benzazepines; Cardiovascular Agents; Fumarates; Hepatitis B; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; Humans; Hypoglycemic Agents; Immunoconjugates; Multiple Sclerosis; Natalizumab; Nucleosides; Papillomavirus Vaccines; Pharmacology, Clinical; Piperazines; Pyrazines; Pyrimidinones; Quinoxalines; Ranolazine; Sitagliptin Phosphate; Smoking Cessation; Telbivudine; Thymidine; Triazoles; Varenicline; Viral Vaccines | 2008 |
Emerging therapies for gout.
Topics: Acetamides; Adrenocorticotropic Hormone; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Benzodiazepines; Febuxostat; Gout; Gout Suppressants; Humans; Imino Furanoses; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Melanocortins; Phenylacetates; Polyethylene Glycols; Pyrimidinones; Recombinant Fusion Proteins; Thiazoles; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents | 2014 |
New medications in development for the treatment of hyperuricemia of gout.
Topics: Acetamides; Drug Design; Gout; Gout Suppressants; Humans; Hyperuricemia; Imino Furanoses; Molecular Targeted Therapy; Phenylacetates; Pyrimidinones; Thioglycolates; Triazoles; Uricosuric Agents | 2015 |
Biotransformation and bioactivation reactions - 2015 literature highlights.
Topics: Acetaminophen; Allylbenzene Derivatives; Aniline Compounds; Animals; Anisoles; Benzbromarone; Biotransformation; Humans; Imidazoles; Niacinamide; Nitroimidazoles; Nitrosamines; Oxazoles; Oxazolidinones; Peroxides; Pyrazines; Pyrazoles; Pyridazines; Pyridines; Pyridones; Pyrimidinones; Thiophenes; Triazoles | 2016 |
Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs.
Topics: Adaptor Proteins, Signal Transducing; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Antineoplastic Agents; Cell Cycle Proteins; Chlorobenzenes; Disease Progression; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasms; Nerve Tissue Proteins; Purines; Pyrazoles; Pyrimidinones; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Triazoles | 2017 |
Increased building block access through collaboration.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cooperative Behavior; Drug Industry; Humans; Interdisciplinary Communication; Phosphodiesterase Inhibitors; Protein Conformation; Pyrimidinones; Structure-Activity Relationship; Triazoles | 2018 |
Diaza-1,3-butadienes as Useful Intermediate in Heterocycles Synthesis.
Topics: Butadienes; Hydrazones; Imidazolidines; Imidazolines; Imines; Indoles; Isoquinolines; Lactams; Pyrazoles; Pyrimidinones; Quinazolines; Triazoles | 2022 |
1 trial(s) available for triazoles and pyrimidinones
| Article | Year |
|---|---|
Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Cycle Proteins; Cell Line, Tumor; Discoidin Domain Receptor 1; DNA Methylation; Drug Resistance, Neoplasm; Drug Synergism; Enhancer Elements, Genetic; Epigenesis, Genetic; Female; Heterocyclic Compounds, 4 or More Rings; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice, Inbred BALB C; Mice, SCID; Molecular Targeted Therapy; Nuclear Proteins; Positive Transcriptional Elongation Factor B; Pyridones; Pyrimidinones; RNA Interference; Transcription Factors; Triazoles; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2017 |
61 other study(ies) available for triazoles and pyrimidinones
| Article | Year |
|---|---|
Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9 (3H)-one derivatives. I.
Topics: Anaphylaxis; Animals; Male; Passive Cutaneous Anaphylaxis; Pyrimidinones; Rats; Rats, Inbred Strains; SRS-A; Thiadiazoles; Triazoles | 1992 |
Anxiolytic properties of certain annelated [1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-ones.
Topics: Aggression; Animals; Anti-Anxiety Agents; Conditioning, Operant; Pyrimidinones; Radioligand Assay; Rats; Structure-Activity Relationship; Triazoles | 1991 |
In vivo biliary excretion and in vitro cellular accumulation of thyroxine by rats or cultured rat hepatocytes treated with a novel histamine H1-receptor antagonist.
Topics: Animals; Bile; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Female; Histamine H1 Antagonists; Liver; Pyrimidinones; Rats; Rats, Inbred Strains; Temperature; Thyroxine; Triazoles; Triiodothyronine | 1990 |
In vitro accumulation of thyroid hormones by cultured rat hepatocytes and the biliary excretion of iodothyronines in rats treated with a novel histamine H2-receptor antagonist.
Topics: Animals; Bile; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Histamine H2 Antagonists; Liver; Male; Phenobarbital; Pyrimidinones; Rats; Rats, Inbred Strains; Temperature; Thyroid Hormones; Thyroxine; Triazoles; Triiodothyronine | 1989 |
Studies in the field of pyridazine compounds. Part 21. Structural studies on 6-H-pyrimido[1,2-b]-1,2,4-triazolopyridazines.
Topics: Animals; Cardiotonic Agents; Chemical Phenomena; Chemistry, Physical; Magnetic Resonance Spectroscopy; Pyridazines; Pyrimidinones; Triazoles | 1987 |
Differential sensitivity of human normal and malignant cells to 8-azahypoxanthine in vitro.
Topics: Animals; Cattle; Cell Line; Cells, Cultured; Clone Cells; Culture Media; Culture Techniques; Diploidy; Fibroblasts; HeLa Cells; Humans; Hypoxanthines; Infant, Newborn; Male; Neoplasms; Phosphotransferases; Polyploidy; Purines; Pyrimidinones; Serum Albumin, Bovine; Triazoles | 1971 |
Comparison of antisecretory potency and duration of action of the H2-receptor antagonists AH 22216, cimetidine, ranitidine and SK & F 93479 in the dog.
Topics: Animals; Cimetidine; Dogs; Furans; Gastric Acid; Guanidines; Histamine H2 Antagonists; Male; Piperidines; Pyrimidinones; Ranitidine; Time Factors; Triazoles | 1983 |
Synthesis of 4-triazolopyrimidinone nucleotide and its application in synthesis of 5-methylcytosine-containing oligodeoxyribonucleotides.
Topics: 5-Methylcytosine; Cytosine; Indicators and Reagents; Methods; Oligodeoxyribonucleotides; Oligonucleotides; Phosphorylation; Pyrimidinones; Triazoles | 1981 |
6-(4-pyridinyl)-1H-1,2,3-triazolo[4,5-d]-pyrimidin-4(5H)-one: a structurally novel competitive AMPA receptor antagonist.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Hippocampus; Humans; Pyrimidinones; Receptors, AMPA; Triazoles | 1995 |
Pharmacological actions of SDZ 218-135, a novel positive inotropic agent.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Models, Animal; Electrophysiology; Female; Guinea Pigs; Heart Atria; Hemodynamics; Isometric Contraction; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Ovum; Papillary Muscles; Phosphodiesterase Inhibitors; Piperazines; Potassium; Propranolol; Pyrimidinones; Rabbits; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Triazoles | 1994 |
Mechanism and regulation of neutrophil priming by platelet-activating factor.
Topics: Adult; Amiloride; Azepines; Calcium; Chelating Agents; Diacylglycerol Kinase; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphotransferases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyrimidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Thiazoles; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo.
Topics: Animals; Asthma; Azepines; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Leukotriene Antagonists; Leukotrienes; Male; Platelet Activating Factor; Pyridines; Pyrimidinones; Respiratory Hypersensitivity; Tetrazoles; Triazoles | 1993 |
New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candidiasis; Colony Count, Microbial; Fungi; Male; Mice; Molecular Conformation; Pyrimidinones; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles | 1998 |
The effects of single dose nefazodone and paroxetine upon 5-HT2A binding potential in humans using [18F]-setoperone PET.
Topics: Adult; Analysis of Variance; Antidepressive Agents; Binding, Competitive; Female; Fluorine Radioisotopes; Humans; Male; Paroxetine; Piperazines; Pyrimidinones; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Tomography, Emission-Computed; Triazoles | 1999 |
Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; CD11c Antigen; CD4 Antigens; Cell Cycle; Cell Differentiation; Diacylglycerol Kinase; Enzyme Activators; Enzyme Inhibitors; Farnesol; Flow Cytometry; Genes, fos; Genes, jun; Humans; Immunoblotting; Isoenzymes; Leukemia, Myeloid; Naphthalenes; Oncogene Protein p21(ras); Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Sulfonamides; Thiazoles; Triazoles; Tumor Cells, Cultured | 2002 |
5-Methylsulfanyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one (2-methylthio-8-azaxanthine) monohydrate.
Topics: Crystallography, X-Ray; Hydrogen Bonding; Isomerism; Pyrimidinones; Triazoles; Xanthines | 2006 |
Pivotal moments in HIV treatment: the 14th CROI.
Topics: Anti-Retroviral Agents; Clinical Trials as Topic; Congresses as Topic; Cyclohexanes; HIV Fusion Inhibitors; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Maraviroc; Multicenter Studies as Topic; Organic Chemicals; Pyrimidinones; Pyrrolidinones; Raltegravir Potassium; Treatment Outcome; Triazoles; United States | 2007 |
Report from the XVI International HIV Drug Resistance Workshop.
Topics: Anti-HIV Agents; Cyclohexanes; Drug Resistance, Viral; HIV Fusion Inhibitors; HIV Infections; HIV Integrase Inhibitors; Humans; Lopinavir; Maraviroc; Nitriles; Piperazines; Pyridazines; Pyrimidines; Pyrimidinones; Triazoles | 2007 |
Essramycin: a first triazolopyrimidine antibiotic isolated from nature.
Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry, Physical; Chromatography, Thin Layer; Fermentation; Gram-Negative Bacteria; Gram-Positive Bacteria; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Conformation; Molecular Weight; Pyrimidines; Pyrimidinones; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Streptomyces; Triazoles | 2008 |
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.
Topics: Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Protein Binding; Pyrazoles; Pyrimidines; Pyrimidinones; Receptor, Adenosine A2A; Receptor, Adenosine A3; Substrate Specificity; Triazines; Triazoles | 2009 |
Synthesis and biological activity of pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives: in silico approach.
Topics: Computational Biology; Drug Design; Enzyme Inhibitors; Expert Systems; Gout Suppressants; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrimidinones; Spectrophotometry, Infrared; Thiazoles; Triazoles; Xanthine Oxidase | 2010 |
Synthesis and antitumor screening of new 1,7-diphenyl-3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Doxorubicin; Drug Screening Assays, Antitumor; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Pyrimidinones; Spectrophotometry, Infrared; Triazoles | 2010 |
Ultrasound-assisted synthesis of novel 4-(2-phenyl-1,2,3-triazol-4-yl)-3,4-dihydropyrimidin-(1H)-(thio)ones catalyzed by Sm(ClO(4))(3).
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antiviral Agents; Catalysis; Perchlorates; Pyrimidinones; Samarium; Thiourea; Triazoles; Ultrasonics; Urea | 2010 |
A short synthesis of the triazolopyrimidine antibiotic essramycin.
Topics: Anti-Bacterial Agents; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pyrimidinones; Streptomyces; Triazoles | 2010 |
Synthesis of essramycin and comparison of its antibacterial activity.
Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pyrimidinones; Streptomyces; Triazoles | 2010 |
Synthesis of 6-amino-5-cyano-1,4-disubstituted-2(1H)-pyrimidinones via copper-(I)-catalyzed alkyne-azide 'click chemistry' and their reactivity.
Topics: Alkynes; Catalysis; Copper; Pyrimidinones; Triazoles | 2010 |
Synthesis and antitumor activity of novel pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrimidinones; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2011 |
In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Coordination Complexes; Crystallography, X-Ray; Female; Ligands; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Perchlorates; Pyrimidinones; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2011 |
One-pot synthesis of 1,2,3-triazole linked dihydropyrimidinones via Huisgen 1,3-dipolar/Biginelli cycloaddition.
Topics: Catalysis; Chemistry Techniques, Synthetic; Copper; Pyrimidinones; Triazoles | 2011 |
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pentylenetetrazole; Pyrimidinones; Seizures; Semicarbazides; Structure-Activity Relationship; Triazoles | 2011 |
Synthesis of pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones as potential antimicrobial agents.
Topics: Anti-Bacterial Agents; Antifungal Agents; Drug Discovery; Microbial Sensitivity Tests; Molecular Structure; Pyrimidinones; Structure-Activity Relationship; Triazoles | 2013 |
Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Blotting, Western; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; HSP90 Heat-Shock Proteins; Humans; Indoles; Melanoma; Mice, Nude; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Mutation; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Sulfonamides; Triazoles; Vemurafenib; Xenograft Model Antitumor Assays | 2014 |
Development of a radioiodinated triazolopyrimidine probe for nuclear medical imaging of fatty acid binding protein 4.
Topics: Adipose Tissue; Animals; Autoradiography; Carboxylic Acids; Cell Line; Cell Line, Tumor; Fatty Acid-Binding Proteins; Immunohistochemistry; Iodine Radioisotopes; Male; Mice; Mice, Inbred BALB C; Protein Binding; Pyrimidines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Tissue Distribution; Triazoles | 2014 |
Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication.
Topics: Animals; Antiviral Agents; Chikungunya virus; Chlorocebus aethiops; Pyrimidinones; Structure-Activity Relationship; Triazoles; Vero Cells; Virus Replication | 2014 |
Lanthanide complexes containing 5-methyl-1,2,4-triazolo[1,5-a] pyrimidin-7(4H)-one and their therapeutic potential to fight leishmaniasis and Chagas disease.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Chlorocebus aethiops; Coordination Complexes; Crystallography, X-Ray; Female; Inhibitory Concentration 50; Lanthanoid Series Elements; Leishmania; Leishmania braziliensis; Leishmania infantum; Leishmaniasis; Ligands; Pyrimidinones; Rats; Triazoles; Trypanosoma cruzi; Vero Cells | 2014 |
Synthesis and antiproliferative activity of some new thieno[2,3-d]pyrimidin-4(3H)-ones containing 1,2,4-triazole and 1,3,4-thiadiazole moiety.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; HT29 Cells; Humans; Molecular Structure; Pyrimidinones; Structure-Activity Relationship; Thiadiazoles; Thiophenes; Triazoles | 2014 |
Novel agonists of benzodiazepine receptors: design, synthesis, binding assay and pharmacological evaluation of 1,2,4-triazolo[1,5-a]pyrimidinone and 3-amino-1,2,4-triazole derivatives.
Topics: Animals; Anticonvulsants; Drug Design; GABA-A Receptor Agonists; Male; Mice; Models, Molecular; Pyrimidinones; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 2015 |
Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aza Compounds; Benzimidazoles; beta Catenin; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Indazoles; Indoles; Melanoma; Molecular Targeted Therapy; Mutation; Oxazoles; Oximes; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Pyridones; Pyrimidinones; Quinolines; Sulfonamides; Triazoles; Vemurafenib | 2015 |
Synthesis, Herbicidal Activity, and QSAR of Novel N-Benzothiazolyl- pyrimidine-2,4-diones as Protoporphyrinogen Oxidase Inhibitors.
Topics: Enzyme Inhibitors; Herbicides; Kinetics; Nicotiana; Plant Proteins; Protoporphyrinogen Oxidase; Pyrimidinones; Quantitative Structure-Activity Relationship; Sulfonamides; Triazoles | 2016 |
Multicomponent Synthesis and Evaluation of New 1,2,3-Triazole Derivatives of Dihydropyrimidinones as Acidic Corrosion Inhibitors for Steel.
Topics: Azides; Benzaldehydes; Catalysis; Corrosion; Pyrimidinones; Steel; Triazoles; Urea | 2016 |
Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.
Topics: Animals; Azepines; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Synergism; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; MAP Kinase Signaling System; Mice; Neoplasm Transplantation; Proto-Oncogene Proteins c-myc; Pyridones; Pyrimidinones; Triazoles; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2016 |
The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.
Topics: Anti-Bacterial Agents; Biological Products; Egypt; Marine Biology; Mediterranean Sea; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pyrimidinones; Stereoisomerism; Streptomyces; Triazoles | 2016 |
Design, synthesis, and characterization of (1-(4-aryl)- 1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrimidinones; Structure-Activity Relationship; Triazoles | 2016 |
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.
Topics: Animals; Cartilage; Cattle; Chelating Agents; Collagen; Drug Design; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Pyrimidines; Pyrimidinones; Quinazolines; Thiophenes; Triazoles; Zinc | 2017 |
Enterovirus inhibitory activity of C-8-tert-butyl substituted 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones.
Topics: Animals; Antiviral Agents; Enterovirus; Enterovirus Infections; HeLa Cells; Humans; Microsomes; Pyrimidinones; Rats; Triazoles; Virus Replication | 2017 |
Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Brefeldin A; Cell Membrane; Chlorobenzenes; Fluorescence; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Humans; Liposomes; Naphthols; Pyrazoles; Pyridines; Pyrimidinones; Solutions; Triazoles | 2017 |
Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Drug Combinations; Drug Synergism; Gene Expression Regulation, Bacterial; Ligases; Metalloendopeptidases; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pyrimidinones; Quorum Sensing; Recombinant Proteins; Trans-Activators; Transcription Factors; Triazoles | 2018 |
Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
Topics: Anti-Bacterial Agents; Benzimidazoles; Binding Sites; Drug Discovery; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Heterocyclic Compounds, 2-Ring; Microbial Sensitivity Tests; Molecular Structure; Nucleotidyltransferases; Protein Binding; Pseudomonas aeruginosa; Pyrimidinones; Triazoles | 2018 |
Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity.
Topics: Anti-Bacterial Agents; Benzimidazoles; Binding Sites; Drug Discovery; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Heterocyclic Compounds, 2-Ring; Microbial Sensitivity Tests; Molecular Structure; Mutation; Nucleotidyltransferases; Protein Binding; Pyrimidinones; Triazoles | 2018 |
Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation.
Topics: Antiviral Agents; Cell Proliferation; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyrimidinones; Structure-Activity Relationship; Triazoles | 2018 |
Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Glioma; Humans; Molecular Docking Simulation; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidinones; Rats; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Triazoles | 2018 |
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
Topics: Animals; Azepines; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Interferons; Mice; Mutation; Organoids; Proto-Oncogene Proteins p21(ras); Pyridones; Pyrimidinones; Triazoles; Xenograft Model Antitumor Assays | 2019 |
Bromodomain and extraterminal domain inhibition synergizes with WEE1-inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azepines; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA-Binding Proteins; Drug Synergism; Female; Gene Knockdown Techniques; Heterocyclic Compounds, 2-Ring; Humans; Lung Neoplasms; Mice; Piperazines; Protein-Tyrosine Kinases; Pyrazoles; Pyridazines; Pyrimidinones; Transcription Factors; Triazoles; Xenograft Model Antitumor Assays | 2020 |
Synthesis, modeling and biological evaluation of some pyrazolo[3,4-d]pyrimidinones and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidinones as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Edema; Female; Granuloma; Inflammation; Molecular Docking Simulation; Molecular Structure; Pyrazoles; Pyrimidinones; Rats, Wistar; Structure-Activity Relationship; Triazoles | 2019 |
Discovery, Structural Optimization, and Mode of Action of Essramycin Alkaloid and Its Derivatives as Anti-Tobacco Mosaic Virus and Anti-Phytopathogenic Fungus Agents.
Topics: Alkaloids; Antiviral Agents; Fungi; Fungicides, Industrial; Molecular Structure; Plant Diseases; Pyrimidinones; Structure-Activity Relationship; Tobacco Mosaic Virus; Triazoles; Virus Assembly | 2020 |
Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Genes, ras; Heterografts; Humans; Indoles; Male; MAP Kinase Signaling System; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Recurrence, Local; Neuroblastoma; Piperidines; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyridones; Pyrimidines; Pyrimidinones; Pyrroles; Triazoles; Vemurafenib | 2020 |
Clearance of HIV infection by selective elimination of host cells capable of producing HIV.
Topics: Animals; Antigens, CD34; Apoptosis; Autophagy; Azepines; CD4-Positive T-Lymphocytes; HIV Infections; HIV-1; Humans; Mice; Organophosphates; Piperazines; Pyridines; Pyrimidinones; RNA, Viral; T-Lymphocytes; Triazoles | 2020 |
Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells.
Topics: Acetylation; Astrocytoma; Azepines; Brain Stem Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; CREB-Binding Protein; Diffuse Intrinsic Pontine Glioma; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Mutation; Nuclear Proteins; Nucleosomes; Proteins; Pyrimidinones; Transcription Factors; Transcriptional Activation; Triazoles | 2020 |
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists.
Topics: Cyclohexanones; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Pyrimidinones; Receptors, G-Protein-Coupled; Receptors, Peptide; Structure-Activity Relationship; Triazoles | 2021 |
Metabolic drug survey highlights cancer cell dependencies and vulnerabilities.
Topics: Biomarkers, Tumor; Cell Survival; Cluster Analysis; Fatty Acids; Genotype; Humans; Leukemia, Myeloid; Monocarboxylic Acid Transporters; Phenotype; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Pyrimidinones; Pyrrolidines; Signal Transduction; Small Molecule Libraries; Symporters; Systems Analysis; Thiophenes; Triazoles; Tumor Cells, Cultured | 2021 |
Enhancing the Anticancer Potential of Targeting Tumor-Associated Metalloenzymes via VEGFR Inhibition by New Triazolo[4,3-
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Matrix Metalloproteinase 2; Metalloproteins; Molecular Docking Simulation; Molecular Structure; Nucleosides; Protein Kinase Inhibitors; Pyrimidinones; Structure-Activity Relationship; Triazoles; Vascular Endothelial Growth Factor Receptor-2 | 2022 |