triazoles has been researched along with kpt-185 in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 20 (95.24) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Blum, W; Caligiuri, M; Croce, CM; Garzon, R; Kauffman, M; Klisovic, R; Marcucci, G; Na, C; Ranganathan, P; Santhanam, R; Shacham, S; Walker, A; Yu, X | 1 |
| Ford, RJ; Kauffman, M; Lee, J; Li, C; Ou, Z; Pham, LV; Shacham, S; Sun, L; Tamayo, AT; Wang, M; Zhang, K; Zhang, L | 1 |
| Berglund, C; Byrd, JC; Chook, YM; Daelemans, D; Farmer, A; Goettl, V; Gupta, S; Jha, S; Johnson, AJ; Kauffman, M; Lapalombella, R; Lucas, D; Mahoney, E; Mani, R; McCauley, D; Mo, X; Sandanayaka, V; Shacham, S; Shechter, S; Sun, Q; Tangeman, L; Williams, K; Zhong, Y | 1 |
| Evans, CP; Inoue, H; Kauffman, M; Landesman, Y; Shacham, S; Weiss, RH; Yang, J | 1 |
| Carrasco, YP; Chook, YM; Guo, X; Hu, Y; Macmillan, J; Mirzaei, H; Sun, Q | 1 |
| Aboukameel, A; Al-Katib, A; Azmi, AS; Kauffman, M; McCauley, D; Mohammad, RM; Shacham, S | 1 |
| Andreeff, M; Burks, JK; Coombes, KR; Davis, RE; Dilip, A; Duvvuri, S; Kantarjian, H; Kauffman, M; Kojima, K; Kornblau, SM; Qiu, YH; Ruvolo, V; Shacham, S; Wang, Z; Zhang, M; Zhang, N | 1 |
| Han, X; Shi, Y; Wang, J; Wang, S; Yao, J | 1 |
| Andreeff, M; Dilip, A; Ishizawa, J; Kauffman, M; Kimura, S; Kojima, K; Kwak, LW; McDonnell, TJ; Neelapu, SS; Quintás-Cardama, A; Ruvolo, V; Shacham, S; Tabe, Y; Yokoo, M; Yoshimura, M | 1 |
| Abou-Samra, AB; Aboukameel, A; Azmi, AS; Gao, J; Kauffman, M; Mohammad, RM; Shacham, S | 1 |
| Han, X; Shen, Y; Shi, Y; Wang, J; Wang, S; Yao, J; Zhang, N | 1 |
| Andreeff, M; Davis, RE; Fujimura, T; Ishizawa, J; Kauffman, M; Kazuno, S; Kojima, K; Ma, W; Matsushita, H; Miida, T; Sekihara, K; Shacham, S; Tabe, Y; Ueno, T; Wang, Z; Yamamoto, S | 1 |
| Andrei, G; Boons, E; Daelemans, D; Jacquemyn, M; Landesman, Y; Neggers, JE; Nogueira, TC; Pannecouque, C; Shacham, S; Snoeck, R; Tamir, S; van den Oord, J; Vanstreels, E; Vercruysse, T | 1 |
| Aboukameel, A; Azmi, AS; Baloglu, E; Bollig-Fischer, A; Dyson, G; Kauffman, M; Landesman, Y; Mohammad, RM; Muqbil, I; Philip, PA; Senapedis, W; Shacham, S; Wu, J | 1 |
| Crochiere, M; Kalid, O; Kashyap, T; Klebanov, B; Landesman, Y; Saint-Martin, JR; Senapedis, W; Shechter, S | 1 |
| Baloglu, E; Crochiere, ML; Del Alamo, D; Donovan, S; Kauffman, M; Klebanov, B; Landesman, Y; Lee, M; Shacham, S | 1 |
| Argueta, C; Bastard, C; Bertrand, P; Bohers, E; Camus, V; Copie-Bergman, C; Cornic, M; Damotte, D; Delarue, R; Dubois, S; Dyer, MJ; Fest, T; Figeac, M; Gaulard, P; Haioun, C; Jais, JP; Jardin, F; Landesman, Y; Lemasle, E; Lemonnier, F; Leroy, K; Maingonnat, C; Mareschal, S; Milpied, N; Moeller, P; Molina, TJ; Ochmann, M; Pelletier, L; Picquenot, JM; Pujals, A; Salles, G; Sola, B; Stamatoullas, A; Sundstrom, C; Tilly, H; Traverse-Glehen, A; Viailly, PJ | 1 |
| Grayton, JE; Miller, T; Wilson-Robles, H | 1 |
| Andreeff, M; Arai, H; Ciurea, S; Han, L; Kaga, N; Kazuno, S; Kikkawa, M; Konopleva, M; Miida, T; Saitoh, K; Sekihara, K; Tabe, Y; Taka, H; Yamamoto, S | 1 |
| Huang, T; Lu, P; Sheng, Z; Wang, S; Xu, Y; Yuan, Y | 1 |
| Ghildyal, R; Mathew, C; Tamir, S; Tripp, RA | 1 |
1 trial(s) available for triazoles and kpt-185
| Article | Year |
|---|---|
CRM1 as a new therapeutic target for non-Hodgkin lymphoma.
Topics: Acrylamides; Acrylates; Animals; Antineoplastic Agents; Caspases; Cell Cycle Checkpoints; Down-Regulation; Exportin 1 Protein; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Karyopherins; Lymphoma, Non-Hodgkin; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Proteins; Proteolysis; Receptors, Cytoplasmic and Nuclear; Thiazoles; Triazoles; Xenograft Model Antitumor Assays | 2015 |
20 other study(ies) available for triazoles and kpt-185
| Article | Year |
|---|---|
Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia.
Topics: Acrylamides; Acrylates; Acute Disease; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Drug Evaluation, Preclinical; Exportin 1 Protein; Female; fms-Like Tyrosine Kinase 3; Humans; Kaplan-Meier Estimate; Karyopherins; Leukemia, Myeloid; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Receptors, Cytoplasmic and Nuclear; Thiazoles; Triazoles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays; Young Adult | 2012 |
Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma.
Topics: Acrylates; Animals; Apoptosis; Cell Line, Tumor; Exportin 1 Protein; Humans; Karyopherins; Lymphoma, Mantle-Cell; Mice; NF-kappa B; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering; Triazoles; Tumor Suppressor Protein p53 | 2013 |
Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
Topics: Acrylates; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cells, Cultured; Crystallography, X-Ray; Exportin 1 Protein; Humans; Immunoblotting; Interleukin-10; Interleukin-6; Karyopherins; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, SCID; Mice, Transgenic; Microscopy, Confocal; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; T-Lymphocytes; Triazoles | 2012 |
CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth.
Topics: Acrylates; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Exportin 1 Protein; Flow Cytometry; Humans; Immunoblotting; Immunohistochemistry; Karyopherins; Kidney Neoplasms; Male; Mice; Mice, Nude; Molecular Targeted Therapy; Neoplasm Transplantation; Random Allocation; Receptors, Cytoplasmic and Nuclear; Sensitivity and Specificity; Survival Rate; Triazoles; Tumor Burden | 2013 |
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Topics: Acrylates; Active Transport, Cell Nucleus; Amino Acid Substitution; Crystallography, X-Ray; Exportin 1 Protein; Fatty Acids, Unsaturated; Humans; Hydrolysis; Karyopherins; Models, Anatomic; Mutagenesis, Site-Directed; Nuclear Export Signals; Protein Conformation; Receptors, Cytoplasmic and Nuclear; Saccharomyces cerevisiae Proteins; Static Electricity; Triazoles | 2013 |
Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas.
Topics: Acrylates; Active Transport, Cell Nucleus; Animals; Exportin 1 Protein; Humans; Karyopherins; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mice; Mice, SCID; Receptors, Cytoplasmic and Nuclear; Treatment Outcome; Triazoles; Tumor Cells, Cultured; Waldenstrom Macroglobulinemia; Xenograft Model Antitumor Assays | 2013 |
Prognostic impact and targeting of CRM1 in acute myeloid leukemia.
Topics: Acrylates; Antineoplastic Agents; Biomarkers, Tumor; Cells, Cultured; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Exportin 1 Protein; Female; HL-60 Cells; Humans; Karyopherins; Leukemia, Myeloid, Acute; Male; Molecular Targeted Therapy; Prognosis; Receptors, Cytoplasmic and Nuclear; Triazoles; Tumor Suppressor Protein p53; U937 Cells | 2013 |
Antitumor effects of a novel chromosome region maintenance 1 (CRM1) inhibitor on non-small cell lung cancer cells in vitro and in mouse tumor xenografts.
Topics: Acrylates; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Enzyme Activation; Exportin 1 Protein; Humans; Karyopherins; Lung Neoplasms; Mice, Inbred NOD; Mice, SCID; Receptors, Cytoplasmic and Nuclear; Triazoles; Xenograft Model Antitumor Assays | 2014 |
Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma.
Topics: Acrylates; Animals; Apoptosis; Exportin 1 Protein; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Karyopherins; Lymphoma, Mantle-Cell; Mice; Mice, Transgenic; Mutation; Prognosis; Receptors, Cytoplasmic and Nuclear; Transcription, Genetic; Triazoles; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2014 |
Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer.
Topics: Acrylates; Active Transport, Cell Nucleus; Animals; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Nucleus; Exportin 1 Protein; F-Box Proteins; F-Box-WD Repeat-Containing Protein 7; Female; Humans; Karyopherins; Mice; Mice, Inbred ICR; Mice, SCID; Pancreatic Neoplasms; Prognosis; Receptor, Notch1; Receptors, Cytoplasmic and Nuclear; Triazoles; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays | 2014 |
Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185.
Topics: Acrylates; Active Transport, Cell Nucleus; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cyclin D1; DNA-Binding Proteins; Elongation Factor 2 Kinase; Exportin 1 Protein; Gene Expression Regulation, Neoplastic; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Humans; Karyopherins; Organelle Biogenesis; Peptide Elongation Factor 1; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-pim-1; Receptors, Cytoplasmic and Nuclear; Ribosomes; Signal Transduction; Transcription Factors; Transcription, Genetic; Triazoles; Tumor Suppressor Protein p53 | 2015 |
Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma.
Topics: Acrylates; Active Transport, Cell Nucleus; Animals; Apoptosis; Base Sequence; Cell Cycle Checkpoints; Cell Line; Cell Nucleus; CRISPR-Cas Systems; Exportin 1 Protein; Female; HIV; Humans; Karyopherins; Lymphoma, AIDS-Related; Mice, Nude; Molecular Sequence Data; Molecular Targeted Therapy; NF-kappa B; Protein Binding; Receptors, Cytoplasmic and Nuclear; Reproducibility of Results; rev Gene Products, Human Immunodeficiency Virus; RNA, Messenger; RNA, Viral; Triazoles; Tumor Suppressor Protein p53; Virus Replication; Xenograft Model Antitumor Assays | 2015 |
Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition.
Topics: Acrylates; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Epithelial-Mesenchymal Transition; Exportin 1 Protein; Fatty Acids, Unsaturated; Humans; Hydrazines; Karyopherins; MCF-7 Cells; Receptors, Cytoplasmic and Nuclear; Snail Family Transcription Factors; Transcription Factors; Triazoles; Xenograft Model Antitumor Assays | 2015 |
Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds.
Topics: Acrylates; Active Transport, Cell Nucleus; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Exportin 1 Protein; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Humans; Karyopherins; Receptors, Cytoplasmic and Nuclear; Triazoles | 2015 |
A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds.
Topics: Acrylamides; Acrylates; Active Transport, Cell Nucleus; Animals; Antibiotics, Antineoplastic; Biotinylation; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Exportin 1 Protein; Fatty Acids, Unsaturated; HCT116 Cells; Humans; Hydrazines; Karyopherins; Leukocytes, Mononuclear; Mice; Molecular Structure; Receptors, Cytoplasmic and Nuclear; Reproducibility of Results; Thiazoles; Triazoles | 2016 |
Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma.
Topics: Acrylates; Active Transport, Cell Nucleus; Adolescent; Adult; Aged; Biomarkers; Cell Line, Tumor; Exportin 1 Protein; Female; Gene Expression Profiling; Hodgkin Disease; Humans; Hydrazines; Karyopherins; Lymphoma, B-Cell; Male; Mediastinal Neoplasms; Middle Aged; Mutation; Receptors, Cytoplasmic and Nuclear; Sequence Analysis, DNA; Triazoles; Young Adult | 2016 |
In vitro evaluation of Selective Inhibitors of Nuclear Export (SINE) drugs KPT-185 and KPT-335 against canine mammary carcinoma and transitional cell carcinoma tumor initiating cells.
Topics: Acrylamides; Acrylates; Active Transport, Cell Nucleus; Analysis of Variance; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Nucleus; Dog Diseases; Dogs; Female; Hydrazines; Reverse Transcriptase Polymerase Chain Reaction; Triazoles | 2017 |
Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1.
Topics: Acrylates; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Line, Tumor; Cell Proliferation; Cell Survival; Energy Metabolism; Exportin 1 Protein; Humans; Karyopherins; Lymphoma, Mantle-Cell; Morpholines; Proteome; Proteomics; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; TOR Serine-Threonine Kinases; Triazoles | 2017 |
XPO1-mediated nuclear export of RNF146 protects from angiotensin II-induced endothelial cellular injury.
Topics: Acrylates; Angiotensin II; Cell Nucleus; Cells, Cultured; Exportin 1 Protein; Human Umbilical Vein Endothelial Cells; Humans; Karyopherins; L-Lactate Dehydrogenase; Oxidative Stress; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Triazoles; Ubiquitin-Protein Ligases | 2018 |
Reversible disruption of XPO1-mediated nuclear export inhibits respiratory syncytial virus (RSV) replication.
Topics: A549 Cells; Acrylates; Cell Nucleus; Drug Evaluation, Preclinical; Exportin 1 Protein; Humans; Karyopherins; Receptors, Cytoplasmic and Nuclear; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Triazoles; Viral Matrix Proteins; Virus Replication | 2021 |