Sleepiness

Synonym
Somnolence
Sleepiness

Excerpt	Reference
"Excessive daytime sleepiness is a common symptom in obese patients with obstructive sleep apnea."	( Beutel, B; Cassel, W; Conradt, R; Hildebrandt, O; Hildebrandt, W; Kesper, K; Koehler, J; Koehler, U; Redhardt, F, 2022)
"Excessive daytime sleepiness is a debilitating symptom of obstructive sleep apnea (OSA) linked to cardiovascular disease, and metabolomic mechanisms underlying this relationship remain unknown."	( Bliwise, DL; Collop, N; Cox, J; Dunbar, SB; Hertzberg, V; Ioachimescu, OC; Kutner, NG; Liu, K; Pak, VM; Rogers, A; Russell, K; Shi, Z; Uppal, K; Yu, T; Zhang, Q, 2022)
"Sleepiness is a behavioural consequence of sleep pressure, which shows interindividual variation, a characteristic possibly related to central sleep mechanisms."	( Andersen, ML; Araujo, P; Fernandes, GL; Tufik, S, 2022)

Excerpt	Reference
"Weekly cataplexy attacks and Epworth Sleepiness Scale can be used to help document clinical response to narcolepsy treatment using criteria of 46% and 12% reductions, respectively."	( Lai, C; Steffen, AD; Weaver, TE, 2018)
"Excessive sleepiness (ES) is a common symptom of OSA, which often persists despite primary OSA therapy."	( Black, J; Carter, LP; Chen, D; Collop, N; Hedner, J; Lee, L; Lorch, DG; Lu, Y; Pépin, JL; Redline, S; Strollo, PJ, 2019)
"This study included 57 sleepy (Epworth Sleepiness Scale (ESS) ≥ 10) and 37 non-sleepy (ESS < 10) participants newly diagnosed and untreated for OSA that completed an overnight in-lab or at home sleep study who were recruited from the Emory Mechanisms of Sleepiness Symptoms Study (EMOSS)."	( Bliwise, DL; Collop, N; Cox, J; Dunbar, SB; Hertzberg, V; Ioachimescu, OC; Kutner, NG; Liu, K; Pak, VM; Rogers, A; Russell, K; Shi, Z; Uppal, K; Yu, T; Zhang, Q, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	59 (35.33)	28.8240
2020's	108 (64.67)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	medium	2	1
carbamates	medium	6	3
choline	low	1	0
3-hydroxybutyric acid	medium	1	1
melatonin	medium	23	7
urea	low	1	0
atenolol	low	1	0
baclofen	low	1	0
buspirone	low	1	0
caffeine	medium	7	2
clobazam	low	1	0
clonidine	low	1	0
cyproheptadine	medium	1	1
diazepam	medium	2	1
ebastine	low	1	0
fenfluramine	low	1	0
fentanyl	medium	1	1
flecainide	low	1	0
furosemide	low	1	0
gabapentin	low	4	0
guanfacine	low	1	0
haloperidol	low	1	0
ibuprofen	medium	1	1
ifosfamide	low	1	0
ketamine	low	1	0
lamotrigine	medium	2	1
loratadine	medium	2	2
lorazepam	medium	1	1
meperidine	medium	1	1
metformin	low	1	0
methadone	low	1	0
methylphenidate	low	1	0
midazolam	low	3	0
mirtazapine	low	1	0
modafinil	medium	7	3
apnea	low	1	0
pamidronate	low	1	0
propofol	low	3	0
risperidone	low	1	0
zaleplon	low	1	0
zolpidem	medium	3	1
zonisamide	low	1	0
corticosterone	low	1	0
triethylenemelamine	medium	1	1
apomorphine	low	1	0
levodopa	low	1	0
methylene blue	low	1	0
phenylalanine	medium	6	3
pyrroles	medium	2	2
megestrol acetate	low	1	0
aripiprazole	medium	2	1
duloxetine hydrochloride	medium	2	1
3-iodobenzylguanidine	low	1	0
6-sulfatoxymelatonin	medium	3	2
triazoles	medium	2	2
zoledronic acid	low	1	0
fingolimod hydrochloride	low	1	0
desloratadine	medium	2	2
methotrexate	low	1	0
rupatadine	medium	1	1
ertapenem	low	1	0
moxifloxacin	low	1	0
eslicarbazepine acetate	low	3	0
lacosamide	medium	4	1
oxytocin	low	1	0
retinol	low	1	0
cocaine	medium	1	1
sodium bicarbonate	low	1	0
cannabidiol	medium	5	3
buprenorphine	low	1	0
lithium	low	1	0
safingol	low	1	0
myelin basic protein	low	1	0
sphingosine	low	1	0
humulene	low	2	0
phenylephrine hydrochloride	low	3	0
levetiracetam	medium	2	1
naloxone	low	1	0
oxycodone	medium	3	2
topiramate	medium	3	2
morphine	medium	3	1
dexmedetomidine	medium	2	1
naltrexone	medium	1	1
morphine-6-glucuronide	medium	1	1
butorphanol	medium	1	1
pregabalin	low	3	0
palonosetron	low	1	0
ucb 34714	medium	5	2
perampanel	medium	7	4
pitolisant	low	1	0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	1	0
lisdexamfetamine dimesylate	medium	2	1
col-144	medium	1	1
sodium oxybate	medium	5	2
piperidines	low	2	0
mirogabalin	medium	1	1
olanzapine	medium	4	2
aprepitant	low	1	0
phenanthrenes	medium	1	1

Protein Targets (933)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Sodium-dependent dopamine transporter	0	11	0	11
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
dopamine D1 receptor	3	0	0	3
thioredoxin reductase	15	0	0	15
GLS protein	10	0	0	10
Thrombopoietin	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
cytochrome P450 2D6 isoform 1	13	0	0	13
cytochrome P450 2C19 precursor	9	0	0	9
ras-related protein Rab-9A	4	0	0	4
histone acetyltransferase KAT2A isoform 1	8	0	0	8
lethal factor (plasmid)	7	0	0	7
POU domain, class 2, transcription factor 1	0	0	0	2
Spike glycoprotein	23	0	0	23
ATP-dependent phosphofructokinase	13	0	0	13
ATAD5 protein, partial	10	0	0	10
TDP1 protein	26	0	0	26
Microtubule-associated protein tau	9	0	0	9
estrogen-related nuclear receptor alpha	26	0	0	26
arylsulfatase A	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	31	0	0	31
Bloom syndrome protein isoform 1	12	0	0	12
D(1A) dopamine receptor	10	0	0	10
lamin isoform A-delta10	30	0	0	30
neuropeptide S receptor isoform A	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Luciferase	8	0	0	8
acetylcholinesterase	11	0	0	11
phosphopantetheinyl transferase	12	0	0	12
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
RAR-related orphan receptor gamma	20	0	0	20
GLI family zinc finger 3	25	0	0	25
AR protein	33	0	0	33
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
estrogen receptor 2 (ER beta)	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	21	0	0	21
progesterone receptor	15	0	0	15
regulator of G-protein signaling 4	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	22	0	0	22
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
farnesoid X nuclear receptor	17	0	0	17
estrogen nuclear receptor alpha	36	0	0	36
cytochrome P450 2D6	21	0	0	21
peroxisome proliferator-activated receptor delta	14	0	0	14
peroxisome proliferator activated receptor gamma	13	0	0	13
aryl hydrocarbon receptor	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	16	0	0	16
thyroid stimulating hormone receptor	14	0	0	14
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
Histone H2A.x	8	0	0	8
cellular tumor antigen p53 isoform a	5	0	0	5
cytochrome P450 2C9 precursor	8	0	0	8
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
vitamin D3 receptor isoform VDRA	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	18	0	0	18
thyroid hormone receptor beta isoform 2	25	0	0	25
mitogen-activated protein kinase 1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	23	0	0	23
nuclear receptor ROR-gamma isoform 1	7	0	0	7
geminin	29	0	0	29
peripheral myelin protein 22	16	0	0	16
cytochrome P450 3A4 isoform 1	12	0	0	12
Gamma-aminobutyric acid receptor subunit pi	12	6	3	21
Solute carrier family 22 member 1	0	14	0	17
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
ATP-binding cassette sub-family C member 3	0	34	0	34
Multidrug resistance-associated protein 4	0	34	0	35
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Bile salt export pump	0	43	0	43
Cellular tumor antigen p53	22	0	0	22
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
5-hydroxytryptamine receptor 1A	0	12	8	20
5-hydroxytryptamine receptor 2C	0	15	0	16
Tryptophan 5-hydroxylase 1	0	2	0	2
D(2) dopamine receptor	0	20	4	28
5-hydroxytryptamine receptor 2A	0	16	1	17
Gamma-aminobutyric acid receptor subunit beta-1	12	6	3	21
Alpha-1B adrenergic receptor	0	15	1	16
Gamma-aminobutyric acid receptor subunit delta	12	6	3	21
Gamma-aminobutyric acid receptor subunit gamma-2	12	6	4	22
D	0	12	0	12
D(3) dopamine receptor	0	9	0	9
5-hydroxytryptamine receptor 1A	0	17	2	19
Alpha-2B adrenergic receptor	0	9	0	9
Glutamate receptor 2	13	0	0	13
Gamma-aminobutyric acid receptor subunit alpha-5	12	6	3	21
Gamma-aminobutyric acid receptor subunit alpha-3	12	6	3	21
D(2) dopamine receptor	0	5	0	5
D(1A) dopamine receptor	0	14	2	19
D(4) dopamine receptor	0	14	2	19
D(1B) dopamine receptor	0	5	0	7
Alpha-2C adrenergic receptor	0	9	0	9
Alpha-2A adrenergic receptor	0	9	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	12	6	3	21
Gamma-aminobutyric acid receptor subunit alpha-2	12	6	3	21
Alpha-1D adrenergic receptor	0	14	1	15
D(1B) dopamine receptor	0	6	0	6
5-hydroxytryptamine receptor 2A	0	20	0	20
Gamma-aminobutyric acid receptor subunit alpha-4	12	6	3	21
Gamma-aminobutyric acid receptor subunit gamma-3	12	6	3	21
5-hydroxytryptamine receptor 1B	0	11	0	11
5-hydroxytryptamine receptor 1D	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	12	6	3	21
D(4) dopamine receptor	0	8	1	9
5-hydroxytryptamine receptor 1F	0	4	0	4
5-hydroxytryptamine receptor 2B	0	12	0	12
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	7	0	7
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
D(3) dopamine receptor	0	21	3	27
5-hydroxytryptamine receptor 3A	0	2	0	2
Alpha-1A adrenergic receptor	0	16	2	18
Histamine H2 receptor	10	0	0	11
5-hydroxytryptamine receptor 7	0	4	0	4
D(2) dopamine receptor	0	18	2	20
Gamma-aminobutyric acid receptor subunit alpha-1	12	6	4	22
Gamma-aminobutyric acid receptor subunit beta-3	12	6	3	21
Gamma-aminobutyric acid receptor subunit beta-2	12	6	4	22
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
GABA theta subunit	12	6	3	21
Canalicular multispecific organic anion transporter 1	0	33	0	33
D	0	4	0	4
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	10	0	0	10
Sigma non-opioid intracellular receptor 1	0	13	0	13
Gamma-aminobutyric acid receptor subunit epsilon	12	6	3	21
5-hydroxytryptamine receptor 3B	0	2	0	2
GALC protein	5	0	0	5
caspase 7, apoptosis-related cysteine protease	10	0	0	10
glucocorticoid receptor [Homo sapiens]	24	0	0	24
retinoid X nuclear receptor alpha	16	0	0	16
pregnane X nuclear receptor	25	0	0	25
G	13	0	0	13
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
caspase-3	10	0	0	10
heat shock protein beta-1	9	0	0	9
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Cytochrome P450 3A4	0	10	1	12
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	0	1
cGMP-dependent protein kinase 1	0	0	1	1
Substance-P receptor	0	1	0	1
Inositol hexakisphosphate kinase 1	13	0	0	13
cytochrome P450 2C9, partial	13	0	0	13
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
5-hydroxytryptamine receptor 3E	0	3	0	3
SMAD family member 2	6	0	0	6
Fumarate hydratase	8	0	0	8
USP1 protein, partial	9	0	0	9
PPM1D protein	4	0	0	4
SMAD family member 3	6	0	0	6
EWS/FLI fusion protein	18	0	0	18
polyprotein	8	0	0	8
67.9K protein	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
mu-type opioid receptor isoform MOR-1	0	0	2	2
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
transcriptional regulator ERG isoform 3	4	0	0	4
5-hydroxytryptamine receptor 2A	0	0	2	2
Solute carrier family 22 member 2	0	5	0	6
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 3B	0	4	1	5
ATP-dependent translocase ABCB1	0	10	0	14
Neuronal acetylcholine receptor subunit alpha-4	2	2	0	4
Neuronal acetylcholine receptor subunit beta-2	2	2	0	4
Alpha-2C adrenergic receptor	0	19	2	21
Muscarinic acetylcholine receptor M3	0	12	0	12
Alpha-1D adrenergic receptor	0	17	1	18
5-hydroxytryptamine receptor 2C	0	22	0	22
Histamine H1 receptor	0	4	0	4
Sodium-dependent serotonin transporter	0	16	0	16
5-hydroxytryptamine receptor 7	0	8	0	8
Alpha-1A adrenergic receptor	0	10	1	11
Histamine H1 receptor	0	21	4	25
Alpha-1B adrenergic receptor	0	7	1	8
5-hydroxytryptamine receptor 2B	0	22	0	22
5-hydroxytryptamine receptor 3A	0	7	1	8
5-hydroxytryptamine receptor 6	0	12	0	12
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
Inositol monophosphatase 1	6	0	0	6
Potassium voltage-gated channel subfamily H member 2	0	28	0	29
5-hydroxytryptamine receptor 3D	0	3	0	3
Multidrug and toxin extrusion protein 2	0	3	0	3
5-hydroxytryptamine receptor 3C	0	3	0	3
Multidrug and toxin extrusion protein 1	0	6	0	6
Histamine H3 receptor	0	6	0	7
Beta-1 adrenergic receptor	0	0	2	2
DNA polymerase iota isoform a (long)	8	0	0	8
Fatty acid-binding protein, liver	0	4	0	4
Urease	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
Beta-3 adrenergic receptor	0	2	1	3
TAR DNA-binding protein 43	6	0	0	6
Beta-2 adrenergic receptor	0	2	1	3
NFKB1 protein, partial	4	0	0	4
activating transcription factor 6	5	0	0	5
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Kappa-type opioid receptor	0	11	1	13
Kappa-type opioid receptor	0	14	7	26
chromobox protein homolog 1	15	0	0	15
muscarinic acetylcholine receptor M1	14	0	0	14
Bile salt export pump	0	4	0	4
Beta-2 adrenergic receptor	0	3	0	3
Angiotensin-converting enzyme	0	1	0	1
Beta-1 adrenergic receptor	0	3	0	3
Beta-3 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Mu-type opioid receptor	0	19	9	32
Delta-type opioid receptor	0	13	5	22
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
thyroid hormone receptor beta isoform a	5	0	0	5
DNA polymerase beta	5	0	0	5
DNA polymerase kappa isoform 1	5	0	0	5
Potassium channel subfamily K member 2	0	1	1	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase 1	0	10	0	15
Carbonic anhydrase 2	0	10	3	18
Cholinesterase	0	3	0	3
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Adenosine receptor A3	0	3	0	3
Replicase polyprotein 1ab	0	4	0	4
Amine oxidase [flavin-containing] A	0	4	0	4
Acetylcholinesterase	0	5	0	5
Adenosine receptor A1	0	5	0	8
Amine oxidase [flavin-containing] B	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	1	4
Adenosine receptor A1	0	2	1	5
Adenosine receptor A2a	0	4	1	9
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Guanine deaminase	0	1	0	1
Acetylcholinesterase	0	4	0	4
L-lactate dehydrogenase A chain	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 2C11	0	2	0	2
Cytochrome P450 2D6	0	5	0	6
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	8	0	8
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Alpha-2B adrenergic receptor	0	18	1	19
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
Cannabinoid receptor 1	0	1	0	2
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	1	1	2
Cytochrome P450 2C19	0	4	0	4
Cannabinoid receptor 2	0	1	1	3
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Cholinesterase	0	3	0	3
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	2	1	3
Transient receptor potential cation channel subfamily V member 2	0	2	1	3
G-protein coupled receptor 55	0	0	1	1
Diacylglycerol lipase-alpha	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	4	0	4
Solute carrier family 22 member 1	0	4	0	6
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Chain A, Ferritin light chain	7	0	0	7
Chain A, Cruzipain	5	0	0	5
Alpha-1B adrenergic receptor	0	0	2	2
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 3	0	3	0	4
Alpha-2A adrenergic receptor	0	17	3	20
Alpha-1A adrenergic receptor	0	0	2	2
Alpha-2B adrenergic receptor	0	0	0	1
Delta-type opioid receptor	0	11	2	16
Mu-type opioid receptor	0	13	2	16
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Nischarin	0	2	0	2
Nischarin	0	2	0	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Amyloid-beta precursor protein	1	3	0	4
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	5	10
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	4	9
Liver carboxylesterase 1	0	0	0	3
Sodium-dependent noradrenaline transporter	0	18	1	19
Sodium-dependent dopamine transporter	0	10	1	11
Gamma-aminobutyric acid receptor subunit beta-3	0	5	3	8
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	5	9
Sodium-dependent serotonin transporter	0	8	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	4	8
Glutamate receptor ionotropic, NMDA 1	0	4	0	6
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	4	8
Gamma-aminobutyric acid receptor subunit beta-2	0	4	4	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	4	0	6
Glutamate receptor ionotropic, NMDA 2B	0	5	0	7
Glutamate receptor ionotropic, NMDA 2C	0	4	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	4	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	4	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	1	4
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	4	0	6
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Transporter	0	9	0	9
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 5A	0	1	0	1
pregnane X receptor	2	0	0	2
nonstructural protein 1	4	0	0	4
IDH1	8	0	0	8
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
survival motor neuron protein isoform d	7	0	0	7
Solute carrier family 22 member 3	0	1	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	0	1	1
Androgen receptor	0	3	0	3
C-8 sterol isomerase	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	2	0	2
Nuclear receptor ROR-gamma	3	0	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
thyroid stimulating hormone receptor	9	0	0	9
huntingtin isoform 2	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
chaperonin GroEL	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	16	0	16
Prostaglandin G/H synthase 1	0	3	0	3
Aldo-keto reductase family 1 member B1	0	10	0	10
Muscarinic acetylcholine receptor M2	0	9	0	9
Muscarinic acetylcholine receptor M4	0	10	0	10
Muscarinic acetylcholine receptor M3	0	5	0	5
Muscarinic acetylcholine receptor M4	0	5	0	5
Muscarinic acetylcholine receptor M5	0	5	0	5
Muscarinic acetylcholine receptor M5	0	11	0	11
Muscarinic acetylcholine receptor M2	0	5	0	5
Glycogen phosphorylase, brain form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Muscarinic acetylcholine receptor M1	0	10	1	11
Angiotensin-converting enzyme	0	10	0	10
Endothelin receptor type B	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	4
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	10	0	10
5-hydroxytryptamine receptor 2C	0	3	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	3
D(2) dopamine receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	9	0	9
Histone-lysine N-methyltransferase SETD7	0	2	0	2
Chain A, Beta-lactamase	4	0	0	4
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
thioredoxin glutathione reductase	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	0	1	0	1
Protein farnesyltransferase subunit beta	0	1	0	1
Sodium-dependent neutral amino acid transporter B(0)AT2	0	3	0	3
Gamma-aminobutyric acid	0	1	0	1
glp-1 receptor, partial	7	0	0	7
Voltage-dependent L-type calcium channel subunit alpha-1F	0	7	0	7
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	2	3	6
Albumin	0	0	4	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Translocator protein	0	4	2	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Translocator protein	0	1	0	1
Translocator protein	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1S	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1C	0	10	0	10
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Smad3	3	0	0	3
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Alpha-synuclein	3	1	0	4
Caspase-7	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
caspase-3	1	0	0	1
Epidermal growth factor receptor	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	2	1	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
Histamine H4 receptor	0	3	0	3
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
P2X purinoceptor 4	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Delta-type opioid receptor	0	13	4	18
Mu-type opioid receptor	0	15	5	23
Kappa-type opioid receptor	0	9	4	14
Mu-type opioid receptor	0	7	3	14
Sigma non-opioid intracellular receptor 1	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	5	0	5
Sphingosine 1-phosphate receptor 1	0	0	1	1
RCG53912, isoform CRA_a	0	0	0	1
Sphingosine kinase 1	0	0	0	1
Sphingosine kinase 2	0	1	0	2
Sphingosine kinase 1	0	2	0	3
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Cytochrome P450 2J2	0	5	0	5
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	7	0	7
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	6	0	11
Carbonic anhydrase 3	0	5	0	7
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Carbonic anhydrase 4	0	6	0	11
Carbonic anhydrase 6	0	5	0	10
Serum paraoxonase/arylesterase 1	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	6	2	13
Carbonic anhydrase 7	0	5	0	10
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Carbonic anhydrase 9	0	7	0	12
Carbonic anhydrase 13	0	2	0	7
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	6	0	11
Carbonic anhydrase 5B, mitochondrial	0	6	0	11
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
15-lipoxygenase, partial	5	0	0	5
glucocerebrosidase	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
peripheral myelin protein 22 isoform 1	5	0	0	5
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	3
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	5
Adenylate cyclase type 3	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	3	0	4
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	3	0	3
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	4	0	4
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	2	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Albumin	0	1	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 8	0	1	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	3	0	3
Potassium voltage-gated channel subfamily E member 1	0	4	0	4
Potassium voltage-gated channel subfamily KQT member 1	0	4	0	4
Sodium channel protein type 10 subunit alpha	0	1	0	1
Carbonic anhydrase 13	0	4	0	5
Carbonic anhydrase 15	0	3	0	5
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Dihydrofolate reductase	0	4	2	6
flap endonuclease 1	4	0	0	4
Synaptic vesicle glycoprotein 2A	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
WRN	1	0	0	1
integrase, partial	0	2	0	2
lens epithelium-derived growth factor p75	0	2	0	2
apical membrane antigen 1, AMA1	2	0	0	2
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	4	0	0	4
M-phase phosphoprotein 8	4	0	0	4
Polyphenol oxidase 2	0	0	0	1
Plasma kallikrein	0	0	0	2
Tyrosine-protein kinase Lck	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Tyrosinase	0	1	0	1
Carbonic anhydrase	0	2	0	4
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	2	0	4
Large neutral amino acids transporter small subunit 1	0	2	0	3
SLC16A10 protein	0	0	0	2
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	4
Monocarboxylate transporter 10	0	0	0	2
phosphoglycerate kinase	2	0	0	2
isocitrate dehydrogenase 1, partial	2	0	0	2
alpha-galactosidase	3	0	0	3
Platelet-activating factor receptor	0	2	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Bile acid receptor	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
bioA	0	0	0	1
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
interleukin 8	2	0	0	2
ClpP	2	0	0	2
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Kappa-type opioid receptor	0	6	3	11
Dipeptidyl peptidase 4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	3	3
Aldehyde oxidase 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	3	4
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
hypothetical protein, conserved	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Vpr	2	0	0	2
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Cruzipain	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	2
DNA gyrase subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA gyrase subunit A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	3
Nociceptin receptor	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	3	0	4
Farnesyl pyrophosphate synthase	0	4	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	3	0	3
Glutamate receptor 1	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Histamine H3 receptor	0	1	0	1
Histamine H3 receptor	0	1	1	2
Histamine H3 receptor	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
endonuclease IV	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Carbonic anhydrase 4	0	2	0	2
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Butyrophilin subfamily 3 member A1	0	0	1	2
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (167)

Protein Targets (933)

Sleepiness

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (167)

Drugs Studied (117)

Protein Targets (933)