| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347170 | Vero cells viability counterscreen for qRT-PCR qHTS assay of selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347171 | Orthogonal mCherry assay for qRT-PCR qHTS of selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347163 | 384 well plate NINDS AMC confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347156 | DAPI mCherry counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347172 | Secondary qRT-PCR qHTS assay for selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347158 | ZIKV-mCherry secondary qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347164 | 384 well plate NINDS Rhodamine confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347157 | Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID733016 | Antidiabetic activity in Zucker fatty rat assessed as reduction in blood glucose level at 3 mg/kg/day, po measured after 14 days by OGTT relative to vehicle-treated control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733051 | Transactivation of GAL4 DBD-fused human PPARgamma-LBD expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay relative to rosiglitazone | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733024 | Cmax in Sprague-Dawley rat at 100 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID1447960 | Agonist activity at human PPARgamma LBD expressed in HEK293 cells assessed as coactivator DRIP205 protein recruitment after 18 hrs by HTRF assay | 2017 | Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11
| Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics. |
| AID1409296 | Transactivation of GAL4-fused human PPARgamma transfected in HEK293BENA cells at 1 uM after 24 hrs by steady glo-luciferase reporter gene assay relative to pioglitazone | | | |
| AID733048 | Agonist activity at human PPARdelta at < 10 uM | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733013 | Antidiabetic activity in Zucker fatty rat assessed as body weight gain at 3 mg/kg/day, po measured after 14 days relative to vehicle-treated control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733032 | AUC (0 to 24 hrs) in Sprague-Dawley rat at 2 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733049 | Agonist activity at human PPARalpha at < 10 uM | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733029 | Cmax in Sprague-Dawley rat at 0.1 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733046 | Agonist activity at human LXR at < 10 uM | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733042 | Agonist activity at rat PPARgamma at < 10 uM | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733028 | Cmax in Sprague-Dawley rat at 0.3 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID1409298 | Agonist activity at PPARgamma in human MKN45 cells assessed as cell differentiation after 5 days by Hoechst 33342 staining-based assay | | | |
| AID733027 | Cmax in Sprague-Dawley rat at 2 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733041 | Agonist activity at rat PPARdelta at < 10 uM | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID1447959 | Agonist activity at human GAL4 fused PPARgamma-Hinge-LBD expressed in HEK293T cells after 18 hrs by luciferase reporter gene assay relative to rosiglitazone | 2017 | Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11
| Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics. |
| AID733035 | AUC (0 to 24 hrs) in Sprague-Dawley rat at 0.1 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733018 | Antidiabetic activity in KKAy diabetic mouse model assessed as body weight gain at 30 mg/kg/day administered through feeding for 3 days measured on day 4 relative to vehicle-treated control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733026 | Cmax in Sprague-Dawley rat at 1 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733031 | AUC (0 to 24 hrs) in Sprague-Dawley rat at 30 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733034 | AUC (0 to 24 hrs) in Sprague-Dawley rat at 0.3 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID1447961 | Agonist activity at human PPARgamma LBD expressed in HEK293 cells assessed as coactivator DRIP205 protein recruitment after 18 hrs by HTRF assay relative to rosiglitazone | 2017 | Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11
| Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics. |
| AID733512 | Transactivation of GAL4 DBD-fused human PPARgamma-LBD expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733050 | Inhibition of CYP3A4 (unknown origin) | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733513 | Displacement of [3H]-rosiglitazone from GST-tagged PPARgammaLBD (unknown origin) after 1 hr by scintillation proximity assay | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733039 | Cmax in Sprague-Dawley rat at 5 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733043 | Agonist activity at rat PPARalpha at < 10 uM | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID1447962 | Displacement of [3H]rosiglitazone from human PPARgamma LBD expressed in HEK293 cells by filtration assay | 2017 | Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11
| Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics. |
| AID733023 | Antidiabetic activity in KKAy diabetic mouse model assessed as change in insulin level at 30 mg/kg/day administered through feeding for 3 days measured on day 4 relative to vehicle-treated control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733010 | Ratio of rosiglitazone ED30 to compound ED30 for reduction in blood glucose level in po dosed Zucker fatty rat | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID1447958 | Agonist activity at human GAL4 fused PPARgamma-Hinge-LBD expressed in HEK293T cells after 18 hrs by luciferase reporter gene assay | 2017 | Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11
| Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics. |
| AID1630663 | Displacement of [3H]rosiglitazone from PPARgamma (unknown origin) | 2016 | Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
| Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists. |
| AID1447963 | Antidiabetic activity in Zucker fa/fa rat assessed as decrease in blood glucose levels at 0.3 mg/kg administered via oral gavage for 14 days by oral glucose tolerance test | 2017 | Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11
| Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics. |
| AID1409295 | Transactivation of GAL4-fused human PPARgamma transfected in HEK293BENA cells after 24 hrs by steady glo-luciferase reporter gene assay | | | |
| AID733045 | Agonist activity at human PXR at < 10 uM | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733044 | Agonist activity at human RXR at < 10 uM | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733047 | Agonist activity at human FXR at < 10 uM | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733040 | AUC (0 to 24 hrs) in Sprague-Dawley rat at 5 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733030 | AUC (0 to 24 hrs) in Sprague-Dawley rat at 100 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733011 | Antidiabetic activity in po dosed Zucker fatty rat assessed as reduction in blood glucose level measured after 14 days | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733025 | Cmax in Sprague-Dawley rat at 30 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID733033 | AUC (0 to 24 hrs) in Sprague-Dawley rat at 1 mg/kg, po | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID1409304 | Antidiabetic activity in db/db diabetic mouse model assessed as reduction in blood glucose levels relative to vehicle-treated control | | | |
| AID733022 | Antidiabetic activity in KKAy diabetic mouse model assessed as reduction in blood glucose level at 30 mg/kg/day administered through feeding for 3 days measured on day 4 relative to vehicle-treated control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2009 | Journal of molecular biology, Mar-13, Volume: 386, Issue:5
| INT131: a selective modulator of PPAR gamma. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |