Page last updated: 2024-08-24

triazoles and thiazoles

triazoles has been researched along with thiazoles in 340 studies

Research

Studies (340)

TimeframeStudies, this research(%)All Research%
pre-199022 (6.47)18.7374
1990's63 (18.53)18.2507
2000's117 (34.41)29.6817
2010's111 (32.65)24.3611
2020's27 (7.94)2.80

Authors

AuthorsStudies
Fotsch, C; St Jean, DJ1
Cheng, CC; Daves, GD1
Bollag, JM; Henniger, NM1
Arrigo-Reina, R; Barbera, F; Castorina, C; Catti, T; Chiechio, S; Mazzone, G; Mazzone, S; Panico, A; Pignatello, R; Russo, A1
Turner, NC; Wood, LJ1
Cermelli, C; Costantino, L; Malagoli, M; Pecorari, P; Provvisionato, A; Rinaldi, M1
Lohmeyer, M; Workman, P1
Binnaka, T; Fujimura, K; Inoue, K; Kitagawa, S; Kubota, Y; Mizuno, T; Tani, K; Yamaguchi, T1
Lewis, SA; Raeburn, D; Underwood, SL1
Aboul Wafa, OM; Berto, FA1
Cavero, I; Floch, A; Sedivy, P; Tahraoui, L1
Bernat, A; Gigo, V; Herbert, JM; Lale, A; LaPlace, MC; Le Fur, G; Lespy, L; Maffrand, JP; Savi, P; Valette, G1
Hara, H; Mase, T; Murase, K; Nagaoka, H; Saito, M; Tomioka, K; Yamada, T1
Gilfillan, AM; Hope, WC; Patel, BJ; Welton, AF; Wiggan, GA1
Herbert, JM; Lespy, L; Maffrand, JP1
Braquet, P; Ferreira, MG; Fonteles, MC1
Hirafuji, M; Shinoda, H1
Bonne, C; Meynier, F; Muller, A1
Horie, M; Mase, T; Nagaoka, H; Sakurai, Y; Tomioka, K; Yamada, T1
Bloom, JW; Gomez, J; Halonen, M; Yamamura, HI1
Bazill, GW; Dexter, TM1
Davenport, JD; Hirsch, KS; Holden, HE; Jones, CD; Krumkalns, EV; Stamm, N; Suhr, RG; Taylor, HM; Winter, MA1
Ishimaru, T; Kashi, T; Sakagami, K; Sakai, M1
Amico-Roxas, M; Blandino, G; Bonina, F; Caruso, A; Mazzone, G; Panico, AM; Vanella, A1
Reeves, JJ; Stables, R1
Bozza, PT; Cordeiro, RS; Dias, PM; Faria Neto, HC; Lima, MC; Martins, MA; Silva, PM; Vargaftig, BB1
Bernier, JL; Helbecque, N; Henichart, JP; Houssin, R1
Barnes, PJ; Birke, FW; Dent, G; Robaut, C; Sybrecht, GW; Ukena, D1
Coleman, WG; Williams, LS1
Kano, S1
Berk, S; Gisser, H1
Kochhar, MM; Williams, BB1
Andolsek, A; Likar, M; Schauer, P; Stanovnik, B; Tisler, M1
Dunoff, RY; Graboyes, H; Jaffe, G; Karash, CB; Pachter, IJ; Snader, K; Weinstock, J1
Doorenbos, NJ; Dorn, CP1
Almirante, L; Gamba, A; Mugnaini, A; Murmann, W; Olivi, A; Polo, L; Provinciali, E; Rugarli, P1
Brittain, RT; Jack, D1
Ahgren, C; Backro, K; Bell, FW; Cantrell, AS; Clemens, M; Colacino, JM; Deeter, JB; Engelhardt, JA; Hogberg, M; Jaskunas, SR1
Bado, A; Braquet, P; Laigneau, JP; Lewin, MJ; Moizo, L; Sobhani, I; Tarrade, T1
Caliş, U; Demirdamar, R; Erol, DD; Ertan, M; Yuluğ, N1
Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J1
Akgün, H; Ertan, M; Rübsemann, K; Tozkoparan, B1
Araújo, CV; Barbosa-Filho, JM; Bozza, PT; Castro-Faria-Neto, HC; Cordeiro, RS; Moreira, S; Thomas, G; Tibiriçá, EV1
Heard, SO; Perkins, M; Toth, I1
Cesur, N; Cesur, Z1
Imanishi, N; Koike, H; Morooka, S; Natsume, Y1
Dikshit, M; Kumari, R; Seth, P; Srimal, RC1
Asakura, K; Narita, S1
Bird, IN; Daniels, RH; Elmore, MA; Finnen, MJ; Hill, ME1
Farkas, I; Mahmoud, SH; Somsák, L1
Bachy, A; Fraisse, L; Herbert, JM; Keane, PE; Lale, A; Laplace, MC; Lassalle, J; Roche, B; Savi, P; Valette, G1
Chevallet, P; Demirayak, S; Erol, K; Kiliç, FS; Zitouni, G1
Gay, JC1
Bourdon, V; Damas, J; Remacle-Volon, G1
Giudice, A; Herbert, JM; Le Fur, G; Maffrand, JP; Manara, L; Manzoni, L1
Chignard, M; Paulin, D; Renesto, P; Vicart, P1
Hata, K; Katsu, K; Kimura, J; Miki, H; Nakamura, T; Toyosawa, T1
Hata, K; Katsu, K; Kimura, J; Miki, H; Moriyama, M; Toyosawa, T1
Bialer, M; Johannessen, SI; Kupferberg, HJ; Levy, RH; Loiseau, P; Perucca, E1
Chen, J; Giris, N1
Kakinuma, H; Kaku, Y; Naito, T; Tsukada, I; Tsuruoka, A; Yanagisawa, M1
el-Hawash, SA; Habib, NS1
Baker, R; Botsford, JL; Navarez, J; Riley, R; Rivera, J; Wright, T1
Akiyama, M; Ino, M; Miwa, M; Shimura, M; Sugatani, J; Suzuki, M; Suzuki, Y; Yamazaki, R1
Bonner, DP; Fung-Tomc, JC; Huczko, E; Minassian, B1
Kakinuma, H; Kaku, Y; Naito, T; Nara, K; Tsukada, I; Tsuruoka, A; Yanagisawa, M1
Algueró, M; Bartroli, J; Boncompte, E; Conte, L; Forn, J; García-Rafanell, J; Merlos, M; Ramis, J; Turmo, E; Vericat, ML1
Bruyneel, E; Chastre, E; Gespach, C; Kotelevets, L; Mareel, M; Myssiakine, E; Noë, V1
Brandt, ME; Doern, GV; Hajjeh, RA; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA1
Engelhardt, P; Högberg, M; Kangasmetsä, J; Noréen, R; Sahlberg, C; Vrang, L; Zhang, H1
Aoki, FH; Branchini, ML; Mikami, Y; Miyaji, M; Nishimura, K; Taguchi, H; Yamamoto, K; Yang, HC; Yazawa, K1
Coleman, DC; Gee, S; Joly, S; Messer, SA; Pfaller, MA; Pujol, C; Soll, DR; Sullivan, DJ1
Bertaccini, G; Coppelli, G; Coruzzi, G; Poli, E; Pozzoli, C1
Matsushima, T; Nakajima, M; Niki, Y1
Fun, HK; Govindasamy, L; Jayanthi, G; Puviarasan, K; Raj, S; Shanmuga, S; Velmurugan, D1
Diekema, DJ; Doern, GV; Hollis, RJ; Houston, A; Jones, RN; Messer, SA; Pfaller, MA1
Dy, LC; Pei, Y; Travers, JB1
Bonner, DP; Fung-Tomc, JC; Huczko, E; Minassian, B; White, TC1
Demirdamar, R; Ertan, M; Ertan, R; Kelicen, P; Kilcigil, GA; Tozkoparan, B1
Denning, DW; Moore, CB; Walls, CM1
Balzarini, J; Bird, LE; Diprose, J; Esnouf, RM; Ikemizu, S; Milton, J; Ren, J; Slater, M; Stammers, DK; Stuart, DI; Warren, J1
Siatra-Papastaikoudi, T; Tiligada, E; Tsantili-Kakoulidou, A; Varvaresou, A1
Berthou, C; Bourge, JF; Denizot, Y; Geromin, D; Sasportes, M; Sigaux, F; Soulié, A; Zhang, Y1
Borgers, M; Borghgraef, P; Dillen, L; Goossens, J; Nobels, G; Sanz, G; Stoppie, P; Szel, H; Van Hove, C; Van Nyen, G; Van Wauwe, J; Vanden Bossche, H; Venet, M; Willemsens, G1
Hollis, RJ; Houston, A; Jones, RN; Messer, SA; Pfaller, MA; Yamazumi, T1
Mao, C; Sudbeck, EA; Uckun, FM; Venkatachalam, TK1
Andriole, VT; Marino, S; Roberts, J; Schock, K1
Cooper, S1
Carrillo, AJ; Guarro, J1
Aktay, G; Ertan, M; Tozkoparan, B; Yesilada, E1
Diekema, DJ; Fluit, AC; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA; Sader, HS1
Clemons, KV; Stevens, DA1
Bobade, AS; Khadse, BG; Paranjape, SD1
Coco, BJ; Kirkpatrick, WR; Patterson, TF; Perea, S1
Calderon, L; Clemons, KV; Martinez, M; Stevens, DA1
Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS1
Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA1
Fukayama, N; Hayasaki, Y; Mikamo, H; Satoh, M; Shimamura, Y; Tamaya, T; Uesugi, K; Yin, XH1
Boyken, L; Diekema, DJ; Hollis, RJ; Huynh, H; Messer, SA; Pfaller, MA1
Diekema, DJ; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA2
Arikan, S; Rex, JH1
Habel, F; Hoban, D; Laverdiere, M; Restieri, C1
Eppinger, E; Meinhardt, G; Schmidmaier, R1
Ichihara, S; Murasaki, C; Ohwada, J; Shimma, N; Umeda, I; Yamazaki, T1
Lira, R; Payares, G; Romanha, AJ; Sanoja, C; Urbina, JA1
Andes, D; Conklin, R; Marchillo, K; Stamstad, T1
Kamei, K1
Acklin, P; Alberti, D; Buehlmayer, P; Hauffe, S; Lattmann, R; Nick, H; Schupp, J1
Avila, NA; Bacher, J; Casler, HE; Groll, AH; Kelaher, AM; Lyman, CA; Petraitiene, R; Petraitis, V; Sarafandi, AA; Sein, T; Walsh, TJ1
Barrett, C; Guidato, S; Guthrie, S1
Sutton, DA1
Gupta, AK; Tomas, E1
Arion, VB; Fremuth, M; Jakupec, MA; Keppler, BK; Kukushkin, VY; Pombeiro, AJ; Reisner, E1
DAS, NK; PADHI, B; ROUT, MK1
BALLONOFF, LB; FEINSTEIN, RN; SEAHOLM, JE1
GRAY, AP; HEITMEIER, DE1
BUCHSCHACHER, P; FRIED, JH; HANNAH, J; MROZIK, H1
Capilla, J; Guarro, J; Ortoneda, M; Pastor, FJ; Rinaldi, MG; Serena, C; Sutton, DA1
Barbour, N; Bronson, JJ; Chen, CP; Clark, J; Connolly, TP; Dali, M; Gao, Q; Golik, J; Huang, S; Hudyma, TW; Kang, SH; Knipe, J; Lamb, L; Mathew, M; Matiskella, JD; Medin, I; Mosure, K; Tejwani, R; Ueda, Y; Varia, S; Venkatesh, S; Zheng, M1
Abdel Aleem, AH; Abdel-Aal, MT; El Ashry, ES; El-Sayed, WA1
El-Bendary, ER; Gineinah, MM; Nasr, MN1
Bonner, D; Fung-Tomc, J; Huczko, E; Minassian, B; Washo, T1
Cai, C; Katritzky, AR; Singh, SK; Suzuki, K1
Capilla, J; Guarro, J; Javier Pastor, F; Ortoneda, M; Pujol, I1
SEALE, EE1
Foroumadi, A; Moshafi, MH; Rezaee, MA; Soltani, F1
Boyken, L; Diekema, DJ; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA1
Ertan, M; Gökhan, N; Küpeli, E; Tozkoparan, B; Yeşilada, E1
Armstrong, D; Avila, NA; Bacher, J; Groll, AH; Hemmings, M; Lyman, CA; Mickiene, D; Peter, J; Petraitiene, R; Petraitis, V; Roussillon, K; Walsh, TJ1
Andreotti, E; Manfrini, M; Mares, D; Romagnoli, C; Vicentini, CB1
Chiba, K; Kashimoto, S; Sato, Y; Shibamori, K; Tomita, K; Tsuzuki, Y1
Dudding, T; Houk, KN1
Mao, C; Uckun, FM; Venkatachalam, TK1
Chun, MW; Chung, SY; Jeong, LS; Kim, JH; Kim, MJ; Lee, SK; Shin, JH1
Auwerx, J; Balzarini, J; Bird, LE; De Clercq, E; Karlsson, A; Oberg, B; Ren, J; Stammers, DK; Stevens, M; Van Rompay, AR1
Boyken, L; Diekema, DJ; Hollis, RJ; Messer, SA; Pfaller, MA; Rice, C; Tendolkar, S1
Gu, Y; Hu, J; Hu, L; Li, W; Luo, M; Niu, F; Wu, Q; Ye, Y1
Cuenca-Estrella, M; Garcia-Effron, G; Gomez-Lopez, A; Mellado, E; Rodriguez-Tudela, JL1
Gil-Lamaignere, C; Müller, FM; Zhu, LP1
Espinel-Ingroff, A; Jones, RN; Pfaller, MA1
Fernández-Torres, B; Guarro, J; Lazéra, Mdos S; Trilles, L; Wanke, B1
Kode, A; Menon, VP; Penumathsa, SV; Rajagopalan, R1
Perfect, JR1
Adolfs, TJ; Borst, AJ; Coolen, HK; de Looff, W; Keizer, HG; Kruse, CG; Lange, JH; McCreary, AC; van Stuivenberg, HH; Veerman, W; Verveer, PC; Wals, HC1
Batra, R; Gupta, AK; Kohli, Y1
Pan, J; Wang, Q; Zhang, Q; Zheng, RL1
Chevallet, P; Kaplancikli, ZA; Kaya, D; Turan-Zitouni, G; Yildiz, MT1
Steinbach, WJ1
Devi, SK; Rajasekharan, KN; Santhoshkumar, TR; Sengupta, S; Smitha, SL; Sreejalekshmi, KG; Thomas, NE1
Chevallet, P; Kaplancikli, ZA; Turan-Zitouni, G1
Conetta, B; Gupta, AK; Leonardi, C; Pierce, PF; Stoltz, RR1
Fothergill, AW; González, GM; Loebenberg, D; Rinaldi, MG; Sutton, DA1
Bacher, J; Groll, AH; Kelaher, A; Mickiene, D; Petraitiene, R; Petraitis, V; Sarafandi, A; Walsh, TJ; Wuerthwein, G1
Hough, LB; Lu, Q; Montero, MJ; Nalwalk, JW; Shan, Z; Svokos, K; Wentland, MP1
Baker, CJ; Pannaraj, PS; Walsh, TJ1
Cuenca-Estrella, M; Garcia-Effron, G; Gomez-Lopez, A; Mellado, E; Monzon, A; Rodriguez-Tudela, JL1
Economides, C; Eracleous, E; Kolnagou, A; Kontoghiorghes, GJ1
Dandia, A; Khaturia, S; Loupy, A; Mérienne, C; Morgant, G; Singh, R1
Hider, RC; Zhou, T1
Grasela, DM; Kanamaluru, V; Marino, MR; O'Mara, EM; Smith, RA; Yan, JH1
Alves, SH; Azevedo, AC; Boff, E; Da Matta, DA; Guarro, J; Loreto, ES; Santurio, JM1
Aperis, G; Mylonakis, E1
Kontoghiorghes, GJ1
Bacher, J; Kelaher, AM; Lin, P; Meletiadis, J; Petraitiene, R; Petraitis, V; Schaufele, RL; Sein, T; Stergiopoulou, T; Walsh, TJ1
Cano, J; Gené, J; Gilgado, F; Guarro, J; Serena, C1
Denning, DW; Gardiner, RE; Howard, SJ; Moore, CB; Park, S; Perlin, DS; Webster, I1
D'Cruz, OJ; Uckun, FM1
Agrawal, RK; Ravichandran, V1
Azuma, T; Fukuda, J; Hata, M; Hikichi, H; Ito, S; Kaneko, N; Kawagoe-Takaki, H; Kawamoto, H; Kimura, T; Maehara, S; Ohta, H; Sakai, N; Satow, A; Suzuki, G1
Scheinfeld, N1
Adams, CL; Cowen, MS; Lawrence, AJ; Short, JL1
Han, X; Wang, DX1
Abdel-Hamid, H; Aouad, MR; Ashry, ES; Kassem, AA; Khattab, ShA; Louis, FF1
Fisher, PW; Hofmann, GA; Janson, CA; Johnson, RK; Kirkpatrick, RB; Ma, C; Marino, JP; Mattern, M; Meek, TD; Ryan, MD; Schulz, C; Smith, WW; Tew, DG; Thompson, SK; Tomazek, TA; Veber, DF; Xiong, WC; Yamamoto, Y; Yamashita, K; Yang, G1
Chhibber, M; Gupta, S; Sinha, S; Surolia, A1
Papakostas, GI; Shelton, RC1
Eckert, A; Mensah-Nyagan, AG; Patte-Mensah, C; Schaeffer, V1
Bartberger, MD; Castro, VM; Chen, M; Emery, M; Fotsch, C; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Johansson, L; Jordan, SR; Komorowski, R; Li, A; Matsumoto, G; McRae, K; Moniz, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J1
Adhikari, S; De, S; Devasagayam, TP; Menon, VP; Tilak-Jain, J1
Alastruey-Izquierdo, A; Alcazar-Fuoli, L; Cuenca-Estrella, M; Mellado, E; Monzon, A; Rodriguez-Tudela, JL1
Knipe, JO; Mosure, KW1
Chen, S; Lui, K; Mori, T; Tamura, T; Zhou, D1
Kruse, CG; Lange, JH1
Karthikeyan, MS1
Ayala, J; Elizondo, M; González, GM1
Kalgutkar, AS; Obach, RS; Soglia, JR; Zhao, SX1
Lewis, JW; Tipton, DA1
Kazan, F; Ozkirimli, S; Tunali, Y1
Bertilsson, L; Hynninen, VV; Korhonen, T; Kurkinen, KJ; Laine, K; Neuvonen, PJ; Olkkola, KT1
Abe, H; Morita, H; Sakai, M; Sheikh, MC; Takagi, S1
Akita, N; Fukutomi, T; Gonzalez, FJ; Hossain, MA; Kimura, G; Ogata, M; Staels, B; Suzuki, S; Tsujita, M; Yokoyama, S1
Barile, E; Chen, LH; Chen, V; Dahl, R; De, SK; Emdadi, A; Machleidt, T; Murphy, R; Pellecchia, M; Riel-Mehan, M; Stebbins, JL; Yuan, H1
Baldwin, J; Buckner, FS; Charman, S; Charman, WN; Creason, S; El Mazouni, F; Gujjar, R; Marwaha, A; Phillips, MA; Rathod, PK; Shackleford, DM; White, J; White, KL1
Bailly, C; Baldeyrou, B; Beauchard, A; Besson, T; Chérouvrier, JR; Domon, L; Jaunet, A; Lansiaux, A; Murillo, L; Picot, L; Thiéry, V1
Dannaoui, E; Lortholary, O; Schwarz, P1
Bernier, JL; Brassart, B; Chavatte, P; El Bakali, J; Farce, A; Fontaine, G; Guédin, A; Hénichart, JP; Houssin, R; Klupsch, F; Mergny, JL; Riou, JF; Roussel, P1
Becker, J; Davison, J; Hu, W; Jiang, B; Kauffman, S; Martel, N; Martin, CE; Ocampo, P; Oh, C; Roemer, T; Sillaots, S; Trosok, S; Veillette, K; Wang, H; Xu, D; Yang, M; Zhang, L1
Fassihi, A; Moeinifard, B; Sabet, R1
Barodia, SK; Kumar, JB; Kumari, R; Luthra, PM; Mishra, CB; Prakash, A1
Moloney, A1
Bodade, RG; Dawane, BS; Khandare, NT; Khobragade, CN; Konda, SG1
Hussar, DA2
Auluck, S; Kityk, IV; Reshak, AH; Stys, D1
Goldani, LZ; Pasqualotto, AC; Thiele, KO1
Chandrashekar, SM; Kistayya, C; Mallikarjuna, BP; Rajendraprasad, Y; Suresh Kumar, GV1
Vera-Cabrera, L; Welsh, E; Welsh, O1
Abdel-Rahman, H; Hamada, T; Hamada, Y; Hidaka, K; Igawa, N; Ikari, H; Kimura, T; Kiso, Y; Nagamine, A; Nguyen, JT; Sohma, Y; Tagad, HD; Yamani, A1
Aasen, AJ; Ciocoiu, CC; Hansen, TV; Nguyen, HH; Nikolić, N; Thoresen, GH1
Bahia, MT; Caldas, IS; Carneiro, CM; Crepalde, G; de Lana, M; Diniz, Lde F; Guedes, PM; Talvani, A; Urbina, JA1
Jeong, H; Koh, KH; Yang, K1
Dalton, JT; Li, CM; Lu, Y; Miller, DD; Narayanan, R1
Hong, Y; Rugang, Z; Xiaohe, Z; Xiuqing, S; Yu, Q1
Guarro, J; Mayayo, E; Pastor, FJ; Pujol, I; Ruíz-Cendoya, M; Sutton, DA1
Bovée, JV; Bruijn, IH; Hogendoorn, PC; Schrage, YM; Szuhai, K; Willems, SM1
Chakravarty, D; Challa, R; Cortez, V; Nair, BC; Tekmal, RR; Vadlamudi, RK; Vallabhaneni, S1
Sheng, CQ; Wang, SZ; Zhang, WN1
Ahemad, M; Khan, MS2
Türel, O1
Brown, RM; Duncan, JR; Lawrence, AJ; Ledent, C; Stagnitti, MR1
Chow, MS; Wang, S; Zuo, Z1
De, S; Devasagayam, TP1
Almansour, AI; Arumugam, N; Ashraf Ali, M; Choon, TS; Elumalai, K; Ismail, R; Kumar, RS; Osman, H; Singh, A1
Ashokan, B; Bharathan, A; Komalam, RJ; Rajasekharan, KN; Santhoshkumar, TR; Sengupta, S; Sreerekha, KV; Thamkachy, R; Thomas, SA1
Abdel-Latif, E; Abdel-Wahab, BF; Awad, GE; Mohamed, HA1
Belavagi, NS; Gong, YD; Kalashetti, MB; Khan, AY; Khazi, IA; Mohammed Iqbal, AK1
Bobade, VD; Gaikwad, ND; Patil, SV1
Blum, W; Caligiuri, M; Croce, CM; Garzon, R; Kauffman, M; Klisovic, R; Marcucci, G; Na, C; Ranganathan, P; Santhanam, R; Shacham, S; Walker, A; Yu, X1
An, G; Fang, L; Leung, S; Li, Y; Wang, S; Wang, Y; Wisely, B; Xiang, Z; Zhang, G; Zhang, J; Zhang, W; Zhong, Z; Zhou, L1
Hollóczki, O; Kelemen, Z; Nyulászi, L1
Donald, MB; Kurth, MJ; Phuan, PW; Rodriguez, KX; Shay, H; Verkman, AS1
Dadmal, TL; Janaki Ramaiah, M; Kosurkar, UB; Kumbhare, RM; Pal-Bhadra, M; Pushpavalli, SN1
Chaturvedi, SC; Manivannan, E; Prasanna, S1
Guan, Y; Hu, H; Jiang, J; Lin, C; Pan, Y; Wang, L; Xie, Z; Zhu, D; Zhu, X1
Lekshmi, SU; Rajasekharan, KN; Santhoshkumar, TR; Sengupta, S; Thamkachy, R; Thomas, SA; Vasudevan, S1
Chuprakov, S; Fokin, VV; Kwok, SW1
Hao, GF; Luo, YP; Tan, Y; Wu, QY; Xi, Z; Yang, GF; Yang, SG; Zuo, Y1
Czajkowska, B; Krzystanek, M; Lapray, D; Markowski, G; Pałasz, A; Peyron, C; Rojczyk-Gołębiewska, E; Skowronek, R; Wiaderkiewicz, R1
Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR1
Sebestyén, Z; Szabó, B; Szepesi, K1
Kumar, N; Kumari, N; Luthra, PM; Mishra, CB; Prakash, A; Sharma, D1
Alexander, PW; Chaplin, JH; Charman, SA; Chatelain, E; Hargrove, TY; Keenan, M; Lepesheva, GI; Perez, CJ; Waterman, MR; Wawrzak, Z1
Hoyer, D; Jacobson, LH1
Maehara, S1
Chew, GT; Sahebkar, A; Watts, GF1
Baumgartner, S; Fleischmann, R; Hingorani, V; Kerr, B; Manhard, K; Miner, JN; Polvent, E; Quart, B; Shen, Z; Suster, M; Yeh, LT1
Han, J; Mei, H; Pan, Y; Soloshonok, VA; Xie, C; Xiong, Y1
Jain, MR; Krel, M; Li, H; Perlin, DS; Petraitiene, R; Petraitis, V; Walsh, TJ; Zhao, Y1
Edwards, NL; So, A1
Jansen, TL1
Ambrus, G; Cole, DC; Davenport, R; Ellery, J; Fosbeary, R; Hixon, MS; Jennings, AJ; Kadotani, A; Kamada, Y; Kamran, R; Lanier, M; Matsumoto, S; Mizukami, A; Okada, K; Okubo, S; Saikatendu, K; Walsh, L; Wu, H1
Raboisson, P; Swedberg, MD1
Belaidi, S; Chand, S; Pathak, SK; Prasad, O; Sachan, AK; Sinha, L; Srivastava, R1
Ahmed, SA; de Hoog, GS; Duncanson, F; Fahal, AH; Kloezen, W; van de Sande, WW; Zijlstra, EE1
Andrews, PC; Blair, VL; Brammananth, R; Coppel, RL; Crellin, PK; Luqman, A1
Green, AL; Hsu, JH; Hubbell-Engler, B; Jones, K; Knoff, DS; Kung, AL; Ligon, KL; Maire, CL; McCauley, D; Perry, JA; Ramkissoon, LA; Ramkissoon, SH; Shacham, S1
Al-Harbi, NO; Amr, Ael-G; Bahashwan, SA; Fayed, AA; Ramadan, MA1
Han, X; Shen, Y; Shi, Y; Wang, J; Wang, S; Yao, J; Zhang, N1
Appalanaidu, K; Bhadra, MP; Dadmal, TL; Kishore, KS; Kumbhare, RM; Pushpa Valli, SN; Ramaiah, MJ; Rao, YK; Tiwari, SK1
Abdelhamid, AO; Ahmed, SA; Gomha, SM1
Ikeda, F; Iyoda, T; Mikawa, T; Suzuki, M; Yamaguchi, H1
Ito, TK; Kadariya, Y; Pei, J; Sementino, E; Tan, Y; Testa, JR1
Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A1
Fernández-García, M; Gómez-Garcés, JL; López, D; López-Fabal, F; Tejero, R1
Cominetti, D; De Cesare, M; Deraco, M; Doldi, V; Friedlander, S; Gandellini, P; Kauffman, MG; Landesman, Y; Lopergolo, A; Pennati, M; Shacham, S; Zaffaroni, N1
Alcaro, S; Bianco, G; Ceruso, M; Cottiglia, F; Distinto, S; Maccioni, E; Meleddu, R; Melis, C; Supuran, CT1
Lin, JB; Mast, N; Pikuleva, IA1
Chen, H; Ding, HF; Dong, Z; Fang, D; Huang, S; Jing, Q; Lu, Y; Su, SB; Yang, L1
Fernández-García, M; Gómez-Garcés, JL; Gutiérrez, B; López, D; López-Fabal, F; Tejero, R1
Feng, L; Hua, X; Sheng, E; Shi, H; Wang, M; Yu, T; Zhou, L1
Bancescu, G; Barbuceanu, F; Barbuceanu, SF; Draghici, C; Saramet, G1
Sha, H; Sun, Y; Wei, S1
Baloglu, E; Crochiere, ML; Del Alamo, D; Donovan, S; Kauffman, M; Klebanov, B; Landesman, Y; Lee, M; Shacham, S1
Sabio, M; Topiol, S1
Abrams, C; Aneja, R; Bailey, L; Bastian, AR; Chaiken, I; Huynh, J; Kalyana Sundaram, RV; Li, H; Papazoglou, E; Rashad, AA; Weiss, K; Wrenn, S1
Khouzam, HR1
Asada, M1
Byers, FW; Crouch, RD; Daniels, JS; Emmitte, KA; Lindsley, CW; Morrison, RD1
Babaoglu, K; Brautigam, CA; Clark, L; Coleman, PJ; Gotter, AL; Harrell, CM; Renger, JJ; Roecker, AJ; Rosenbaum, DM; Scheuermann, TH; Shao, Z; Winrow, CJ; Yin, J1
Gupte, A; Hawkins, CJ; Miles, MA; Shekhar, TM; Tascone, B; Taylor, S; Walkley, CR1
Brown, SL; Cuyamendous, C; Field, JJ; Harvey, JE; Hemi Cumming, A; Miller, JH; Tao, X; Teesdale-Spittle, PH1
Garneau-Tsodikova, S; Ngo, HX; Shrestha, SK1
Balmer, ME; Bucheli, TD; Garcia Delgado, MF; Hanke, I; Huntscha, S; Kasteel, R; Poiger, T; Wettstein, FE1
Bogo, G; Bortolotti, L; Bosch, J; Medrzycki, P; Molowny-Horas, R; Porrini, C; Renzi, MT; Sgolastra, F; Teper, D; Tosi, S1
Aboukameel, A; Azmi, AS; Baloglu, E; Bhutani, D; Carlson, R; Elloul, S; Kauffman, M; Mohammad, RM; Muqbil, I; Senapedis, W; Shacham, S; Zonder, J1
Asafo-Adjei, EA; Corey, BW; Ernst, RK; Hittle, LE; Huggins, WM; Jacobs, AC; Melander, C; Melander, RJ; Thompson, MG; Zurawski, DV1
Yamaguchi, H1
Huang, CF; Liu, HS; Ramesh, C; Su, CL; Tseng, CL; Yao, CF1
Cai, Z; Ding, Z; Jiang, Y; Jin, Y; Li, R; Ni, T; Pang, L; Wang, T; Xie, F; Yu, S; Zhang, D; Zhao, J1
Chai, Y; Cheng, J; Cui, K; Ge, J; Li, Y; Liu, X; Yan, H; Yu, X1
Bagul, C; Bhattacharjee, D; Jain, N; Kamal, A; Kapure, JS; Shaik, SP; Subba Rao, AV; Sultana, F; Vishnuvardhan, MVPS1
Antunes, E; Bonilla-Becerra, SM; Calmasini, FB; de Oliveira, MG; Rojas-Moscoso, JA; Zanesco, A1
Blasioli, S; Braschi, I; Medrzycki, P; Molowny-Horas, R; Porrini, C; Renzi, T; Sgolastra, F; Tosi, S1
Benedec, D; Ionuţ, I; Nastasă, C; Oniga, O; Stana, A; Tamaian, R; Tiperciuc, B; Vodnar, DC1
Almeida, IC; Alonso-Vega, C; Alves, F; Gascon, J; Ortiz, L; Pinazo, MJ; Ribeiro, I; Schijman, A; Strub-Wourgaft, N; Torrico, F1
Bahia, MT; Caldas, IS; Diniz, LF; Mazzeti, AL; Ribeiro, I1
Ishii, Y; Ito, Y; Matsuki, S; Ogawa, O; Sanpei, K; Schuck, EL; Takeda, K; Uemura, N1
Cola Fernandes Rodrigues, J; de Souza, W; Lima Prado Godinho, J; Teixeira de Macedo Silva, S; Urbina, JA; Visbal, G1
Arnan, X; Bosch, J; Cabbri, R; Isani, G; Medrzycki, P; Sgolastra, F; Teper, D1
Okubo, A; Tsubouchi, I; Watanabe, S1
Alonso-Vega, C; Alves, F; de la Barra, A; Flevaud, L; Garcia, L; Gascon, J; Illanes, D; Juiz, N; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Schijman, AG; Torrico, F1
Abbas, EMH; Awad, HM; El-Kady, DS; El-Sayed, WA; Kassem, AF1
Chai, HH; Chen, GZ; Chen, WX; Chen, YS; Fu, XC; Guo, YW; Li, SP; Ma, L; Song, MY; Sun, HT; Tan, MX1
Boisbrun, M; Duval, RE; Fontanay, S; Thomas, B; Varbanov, M1
Cuervo-Rodríguez, R; Del Campo, A; Echeverría, C; Fernández-García, M; Muñoz-Bonilla, A; San Martín, M1
Aramaki, C; Kamata, H; Kano, R; Mori, Y; Murayama, N; Yamagishi, K; Yokoi, S1
Fukushima, S; Hiruma, M; Ihn, H; Kano, R; Kimura, U; Matsumoto, T; Noguchi, H; Yaguchi, T2
Akbar, S; Ganapathi, T; Ganesh Kumar, C; Kamal, A; Khan, I; Nagendra Babu, B; Sayeed, IB; Shareef, MA; Sirisha, K1
Ahsan Halim, S; Al-Harrasi, A; Csuk, R; Ibrar, A; Khan, A; Khan, I; Mehsud, S; Saeed, A1
Chen, B; Chen, J; Huang, M; Huang, S; Liu, Y; Sun, Y; Wang, B; Wang, C; Wang, X; Xiong, L; Zhao, N1
Huruta, H; Kamata, H; Kano, R1
Ito, T; Kamata, H; Kano, R; Miura, A; Suzuki, K1
Harada, K; Hase, M; Hiruma, J; Hiruma, M; Kamata, H; Kano, R; Noguchi, H; Yokota, M1
Abrantes, JL; Alves, CM; Cunha, AC; de Freitas, CS; de Melo, GR; Ferreira, VF; Fintelman-Rodrigues, N; Jordão, AK; Marttorelli, A; Sacramento, CQ; Souza, TML1
Kamata, H; Kano, R; Sugita, T1
Bahia, MT; Caldas, IS; Diniz, LF; Machado, YA; Marques, MJ; Martins-Filho, OA; Mazzeti, AL; Novaes, RD; Santos, LJS; Vilas Boas, BR1
Dong, J; Li, D; Li, X; Liu, W; Mei, H; Song, N; Zheng, H1
Au, HYA; Bhattacharyya, T; Chatelain, E; Franco, CH; Freitas-Junior, LH; Giardini, MA; Le, H; Madeira, RP; Miles, MA; Moraes, CB; Pascoalino, BS; Romera, LMD; Schenkman, S; Torrecilhas, AC; Warhurst, DC1
Banothu, J; Bavantula, R; Ganesh Kumar, C; Gondru, R; Kanugala, S; Pasupuleti, M; Raj, S1
Hata, K1
Dong, J; Kan, S; Liang, G; Liu, W; Song, N; Zhang, M; Zheng, H1
Blokhina, SV; Doroshenko, IA; Levshin, IB; Ol'khovich, MV; Perlovich, GL; Sharapova, AV1
Huang, YH; Liu, JG; Miao, CY; Qing, SL; Su, DF; Tian, JS; Wang, P; Wang, SN; Xu, JY; Xu, TY1
Camarasa, MJ; de Lucio, H; Gago, F; García-Soriano, JC; Jiménez-Ruiz, A; Revuelto, A; Sánchez-Murcia, PA; Velázquez, S1
Brêtas, CM; César, IC; Gazzinelli, BP1
Bahia, MT; de Castro, KCMP; Mazzeti, AL; Mendes, PF; Mosqueira, VCF; Spósito, PÁ; Urbina, JA1
Borruso, L; Cesco, S; Lucini, L; Mimmo, T; Miras-Moreno, B; Pii, Y; Puglisi, E; Spini, G; Taskin, E; Tiziani, R; Trevisan, M; Zangrillo, MS1
Alamir, A; Asgari, MS; Bandarian, F; Faramarzi, MA; Hajimiri, MH; Hamedifar, H; Hosseini, S; Iraji, A; Larijani, B; Mahdavi, M; Mojtabavi, S; Moradi, S; Nasli Esfahani, A; Nasli-Esfahani, E1
Chin, CM; Scarim, CB1
Bonifaz, A; Burrows, J; Eadie, K; Fahal, A; Konings, M; Lim, W; Nyuykonge, B; Perry, B; Samby, K; Smeets, J; Todd, M; van de Sande, W; Verbon, A1
Abastabar, M; Badali, H; Bonifaz, A; Fahal, A; Lim, W; Nyuykonge, B; van Amelsvoort, L; van de Sande, W; Verbon, A1
Alavinia, S; Babamoradi, J; Ghorbani-Vaghei, R1
Eisner, JR; Lerner, LM; Michmerhuizen, AR; Pesch, AM; Pierce, LJ; Rae, JM; Schwartz, R; Speers, CW; Ward, C; Wilder-Romans, K; Zhang, A1
Jiang, N; Liu, S; Tan, Z; Wang, F; Wang, X; Yang, J; Zhai, X; Zhang, J1
Guan, Q; Hong, Y; Li, B; Li, M; Li, N; Li, X; Wu, L; Zhang, B; Zhang, W1

Reviews

34 review(s) available for triazoles and thiazoles

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012
The chemistry and biochemistry of C-nucleosides.
    Progress in medicinal chemistry, 1976, Volume: 13

    Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Formycins; Imidazoles; Isoxazoles; Nucleosides; Oxadiazoles; Pseudouridine; Purine Nucleosides; Pyrazoles; Showdomycin; Thiazoles; Triazoles; Uridine

1976
Histamine H2-antagonists--past, present and future.
    Journal of clinical gastroenterology, 1983, Volume: 5 Suppl 1

    Topics: Animals; Aspirin; Burimamide; Chemical Phenomena; Chemistry; Cimetidine; Dogs; Furans; Gastric Acid; Guanidines; Guinea Pigs; Half-Life; Histamine H2 Antagonists; Humans; Imidazoles; Methylamines; Ranitidine; Rats; Stomach; Thiazoles; Triazoles

1983
[Present problems and future trend of antifungals for deep seated mycosis. Azole antifungal agents].
    Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology, 1999, Volume: 40, Issue:3

    Topics: Animals; Antifungal Agents; Azoles; Dosage Forms; Drug Interactions; Drug Resistance, Microbial; Fungi; Humans; Pyrimidines; Thiazoles; Triazoles; Voriconazole

1999
Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase.
    Biochemical pharmacology, 2000, Nov-01, Volume: 60, Issue:9

    Topics: Amino Acid Substitution; Drug Design; Drug Resistance, Microbial; HIV; HIV Reverse Transcriptase; Humans; Models, Molecular; Mutation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Triazoles

2000
Biotransformation reactions of five-membered aromatic heterocyclic rings.
    Chemical research in toxicology, 2002, Volume: 15, Issue:3

    Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics

2002
Ravuconazole Eisai/Bristol-Myers Squibb.
    Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:4

    Topics: Administration, Oral; Animals; Antifungal Agents; Clinical Trials as Topic; Humans; Mycoses; Structure-Activity Relationship; Thiazoles; Triazoles

2002
[Present status and future prospects of azole antifungal agents in Japan].
    The Japanese journal of antibiotics, 2002, Volume: 55, Issue:6

    Topics: Antifungal Agents; Azoles; Cyclodextrins; Drug Design; Fluconazole; Forecasting; Itraconazole; Japan; Miconazole; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
Development of tridentate iron chelators: from desferrithiocin to ICL670.
    Current medicinal chemistry, 2003, Volume: 10, Issue:12

    Topics: Animals; Benzoates; Callithrix; Chemical Phenomena; Chemistry, Physical; Deferasirox; Dihydropyridines; Dogs; Humans; Iron; Iron Chelating Agents; Rats; Thiazoles; Triazoles

2003
Laboratory evaluation of new antifungal agents against rare and refractory mycoses.
    Current opinion in infectious diseases, 2002, Volume: 15, Issue:6

    Topics: Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Echinocandins; Fungi; Humans; Lipopeptides; Microbial Sensitivity Tests; Mitosporic Fungi; Mycoses; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
New antifungal agents.
    Dermatologic clinics, 2003, Volume: 21, Issue:3

    Topics: Administration, Oral; Anidulafungin; Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Chemistry, Pharmaceutical; Drug Approval; Echinocandins; Humans; Lipopeptides; Macrolides; Mycoses; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2003
Antifungal resistance: the clinical front.
    Oncology (Williston Park, N.Y.), 2004, Volume: 18, Issue:14 Suppl 1

    Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Caspofungin; Drug Resistance, Fungal; Echinocandins; Fluconazole; Health Status; Humans; Lipopeptides; Peptides, Cyclic; Pyrimidines; Risk Factors; Thiazoles; Treatment Outcome; Triazoles; United States; Voriconazole

2004
Antifungal agents in children.
    Pediatric clinics of North America, 2005, Volume: 52, Issue:3

    Topics: Age Factors; Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Chemistry, Pharmaceutical; Child; Clinical Trials as Topic; Drug Approval; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Lipopeptides; Lipoproteins; Micafungin; Mycoses; Patient Selection; Pediatrics; Peptides, Cyclic; Pyrimidines; Safety; Thiazoles; Triazoles; United States; Voriconazole

2005
Advances in iron overload therapies. prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NA11 and their combinations.
    Current medicinal chemistry, 2005, Volume: 12, Issue:23

    Topics: Benzoates; Carboxylic Acids; Deferasirox; Deferiprone; Deferoxamine; Drug Therapy, Combination; Hemochromatosis; Humans; Iron Chelating Agents; Iron Overload; Pyridones; Siderophores; Thalassemia; Thiazoles; Triazoles

2005
Newer triazole antifungal agents: pharmacology, spectrum, clinical efficacy and limitations.
    Expert opinion on investigational drugs, 2006, Volume: 15, Issue:6

    Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Cryptococcosis; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Resistance, Fungal; Drug Therapy, Combination; Humans; Pyrimidines; Randomized Controlled Trials as Topic; Thiazoles; Triazoles; Voriconazole

2006
Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers.
    Hemoglobin, 2006, Volume: 30, Issue:2

    Topics: Benzoates; Carboxylic Acids; Chelation Therapy; Clinical Trials as Topic; Deferasirox; Deferiprone; Deferoxamine; Drug Evaluation; Drug Therapy, Combination; Forecasting; Hemochromatosis; Humans; Hydroxyethyl Starch Derivatives; Iron Chelating Agents; Iron Overload; Molecular Structure; Pyridones; Starch; Thalassemia; Thiazoles; Transfusion Reaction; Triazoles

2006
Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase.
    Journal of enzyme inhibition and medicinal chemistry, 2006, Volume: 21, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Anti-Retroviral Agents; Chemistry, Pharmaceutical; Drug Design; Drug Industry; HIV; HIV Reverse Transcriptase; Humans; Models, Chemical; Models, Molecular; Mutation; Pyrimidines; Reverse Transcriptase Inhibitors; Thiazoles; Thymine; Triazoles

2006
A review of deferasirox, bortezomib, dasatinib, and cyclosporine eye drops: possible uses and known side effects in cutaneous medicine.
    Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzoates; Boronic Acids; Bortezomib; Cyclosporine; Dasatinib; Deferasirox; Humans; Iron Chelating Agents; Ophthalmic Solutions; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Randomized Controlled Trials as Topic; Skin Diseases; Skin Neoplasms; Thiazoles; Triazoles

2007
Recent progress in the improvement of the coupling efficiency of "difficult sequences" in peptide synthesis.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:2

    Topics: Acylation; Amino Acid Sequence; Molecular Structure; Organophosphorus Compounds; Peptide Fragments; Peptides; Proline; Resins, Synthetic; Temperature; Thiazoles; Thiocyanates; Triazoles

2007
Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder.
    Acta psychiatrica Scandinavica, 2008, Volume: 117, Issue:4

    Topics: Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Depressive Disorder, Major; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Drug Resistance; Drug Therapy, Combination; Fluoxetine; Humans; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Serotonin 5-HT2 Receptor Antagonists; Thiazoles; Trazodone; Triazoles

2008
Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole.
    Current opinion in investigational drugs (London, England : 2000), 2010, Volume: 11, Issue:2

    Topics: Animals; Antifungal Agents; Clinical Trials as Topic; Drug Resistance, Fungal; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Nitriles; Pyridines; Quinazolines; Thiazoles; Triazoles

2010
Onychomycosis.
    Clinics in dermatology, 2010, Mar-04, Volume: 28, Issue:2

    Topics: Administration, Cutaneous; Administration, Oral; Antifungal Agents; Ciclopirox; Drug Administration Schedule; Drug Therapy, Combination; Fluconazole; Foot Dermatoses; Humans; Itraconazole; Mitosporic Fungi; Morpholines; Naphthalenes; Onychomycosis; Pyridones; Pyrimidines; Terbinafine; Thiazoles; Triazoles; Voriconazole

2010
[Recent advances in the study of new antifungal lead compounds].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:8

    Topics: Antifungal Agents; Fungi; Heterocyclic Compounds; Humans; Lipopeptides; Molecular Structure; Mycoses; Nitriles; Plant Extracts; Plants, Medicinal; Pyridines; Quinazolines; Quinones; Structure-Activity Relationship; Thiazoles; Triazoles

2010
Newer antifungal agents.
    Expert review of anti-infective therapy, 2011, Volume: 9, Issue:3

    Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis, Invasive; Child; Clinical Trials as Topic; Half-Life; Humans; Lipopeptides; Nitriles; Pyridines; Quinazolines; Thiazoles; Triazoles

2011
Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.
    The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:1

    Topics: Acetamides; Animals; Azepines; Benzofurans; Humans; Isoquinolines; Models, Biological; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrimidines; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles; Wakefulness

2014
[Pharmaceutical applications of sulfobuthylether-beta-cyclodextrin].
    Acta pharmaceutica Hungarica, 2013, Volume: 83, Issue:2

    Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antiemetics; Antifungal Agents; Antipsychotic Agents; Aripiprazole; beta-Cyclodextrins; Chemistry, Pharmaceutical; Dosage Forms; Drug Stability; Humans; Hungary; Multiple Myeloma; Oligopeptides; Piperazines; Pyrimidines; Quinolones; Quinuclidines; Solubility; Thiazoles; Triazoles; Voriconazole

2013
Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?
    Neuropeptides, 2013, Volume: 47, Issue:6

    Topics: Acetamides; Animals; Azepines; Behavior, Addictive; Benzofurans; Feeding Behavior; Humans; Intracellular Signaling Peptides and Proteins; Isoquinolines; Mice; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Piperidines; Pyrimidines; Rats; Reward; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles

2013
[Pharmacological characterization of metabotropic glutamate-receptor 1 antagonist for the treatment of schizophrenia].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2013, Volume: 142, Issue:6

    Topics: Animals; Benzimidazoles; Drug Discovery; Humans; Isoindoles; Mice; Molecular Targeted Therapy; Naphthalenes; Protein Binding; Rats; Receptors, Metabotropic Glutamate; Schizophrenia; Thiazoles; Triazoles

2013
New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease.
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:4

    Topics: Acetates; Animals; Atherosclerosis; Chalcones; Cholesterol, HDL; Dyslipidemias; Fatty Liver; Fenofibrate; Humans; Insulin Resistance; Lipoproteins, HDL; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptors; Propionates; Quinolines; Sulfonamides; Thiazoles; Triazoles; Triglycerides

2014
Emerging therapies for gout.
    Rheumatic diseases clinics of North America, 2014, Volume: 40, Issue:2

    Topics: Acetamides; Adrenocorticotropic Hormone; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Benzodiazepines; Febuxostat; Gout; Gout Suppressants; Humans; Imino Furanoses; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Melanocortins; Phenylacetates; Polyethylene Glycols; Pyrimidinones; Recombinant Fusion Proteins; Thiazoles; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents

2014
Psychopharmacology of chronic pain: a focus on antidepressants and atypical antipsychotics.
    Postgraduate medicine, 2016, Volume: 128, Issue:3

    Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Bupropion; Chronic Pain; Humans; Mianserin; Mirtazapine; Olanzapine; Piperazines; Quetiapine Fumarate; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Thiazoles; Trazodone; Triazoles

2016
New drugs 2016, part 1.
    Nursing, 2016, Volume: 46, Issue:4

    Topics: Aminobutyrates; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azabicyclo Compounds; Azepines; Benzazepines; Biphenyl Compounds; Ceftazidime; Drug Approval; Drug Combinations; Humans; Ivabradine; Morphinans; Polyethylene Glycols; Pyridines; Tetrazoles; Thiazoles; Triazoles; United States; United States Food and Drug Administration; Valsartan

2016
Potential of Ravuconazole and its Prodrugs as the New OralTherapeutics for Onychomycosis.
    Medical mycology journal, 2016, Volume: 57, Issue:4

    Topics: Administration, Oral; Antifungal Agents; Arthrodermataceae; Candida; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Discovery; Humans; Onychomycosis; Prodrugs; Thiazoles; Triazoles

2016
Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds.
    Anti-cancer agents in medicinal chemistry, 2022, Volume: 22, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Drug Development; Female; Humans; Thiazoles; Thiosemicarbazones; Triazoles

2022

Trials

9 trial(s) available for triazoles and thiazoles

ArticleYear
A phase I/II randomized, double-blind, placebo-controlled, dose-ranging study evaluating the efficacy, safety and pharmacokinetics of ravuconazole in the treatment of onychomycosis.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2005, Volume: 19, Issue:4

    Topics: Administration, Oral; Antifungal Agents; Double-Blind Method; Drug Administration Schedule; Foot Dermatoses; France; Humans; Nails; Ontario; Onychomycosis; Severity of Illness Index; Thiazoles; Treatment Outcome; Triazoles; United States

2005
The effect of ravuconazole on the pharmacokinetics of nelfinavir in healthy male volunteers.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:2

    Topics: Adolescent; Adult; Anti-HIV Agents; Area Under Curve; Cytochrome P-450 CYP3A; Drug Interactions; Half-Life; Humans; Male; Middle Aged; Nelfinavir; Thiazoles; Triazoles

2006
Voriconazole increases while itraconazole decreases plasma meloxicam concentrations.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Blood Coagulation; Cross-Over Studies; Cyclooxygenase 1; Cytochrome P-450 Enzyme System; Drug Interactions; Genotype; Half-Life; Humans; Itraconazole; Male; Meloxicam; Protein Binding; Pyrimidines; Thiazines; Thiazoles; Thromboxane B2; Triazoles; Voriconazole; Young Adult

2009
Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia.
    Rheumatology (Oxford, England), 2014, Volume: 53, Issue:12

    Topics: Adult; Aged; Colchicine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Thioglycolates; Triazoles; Uric Acid

2014
CRM1 as a new therapeutic target for non-Hodgkin lymphoma.
    Leukemia research, 2015, Volume: 39, Issue:1

    Topics: Acrylamides; Acrylates; Animals; Antineoplastic Agents; Caspases; Cell Cycle Checkpoints; Down-Regulation; Exportin 1 Protein; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Karyopherins; Lymphoma, Non-Hodgkin; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Proteins; Proteolysis; Receptors, Cytoplasmic and Nuclear; Thiazoles; Triazoles; Xenograft Model Antitumor Assays

2015
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.
    The Lancet. Infectious diseases, 2018, Volume: 18, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Parasite Load; Placebos; Polymerase Chain Reaction; Prospective Studies; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult

2018
Clinical Drug-Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects.
    Clinical and translational science, 2018, Volume: 11, Issue:5

    Topics: Administration, Oral; Adult; Antifungal Agents; Biological Assay; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Metabolome; Onychomycosis; Prodrugs; Thiazoles; Triazoles; Young Adult

2018
Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study.
    The Journal of dermatology, 2018, Volume: 45, Issue:10

    Topics: Adult; Aged; Antifungal Agents; Double-Blind Method; Female; Foot Dermatoses; Humans; Male; Middle Aged; Onychomycosis; Prodrugs; Thiazoles; Treatment Outcome; Triazoles; Young Adult

2018
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease.
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Chagas Disease; DNA, Protozoan; Humans; Middle Aged; Monitoring, Physiologic; Nitroimidazoles; Parasite Load; Placebos; Real-Time Polymerase Chain Reaction; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult

2019

Other Studies

297 other study(ies) available for triazoles and thiazoles

ArticleYear
Effect of chemicals used as nitrification inhibitors on the denitrification process.
    Canadian journal of microbiology, 1976, Volume: 22, Issue:5

    Topics: Anaerobiosis; Aniline Compounds; Azides; Mercury; Nitrates; Organometallic Compounds; Pseudomonas; Pyridines; Pyrimidines; Soil Microbiology; Sulfanilamides; Thiazoles; Triazoles

1976
Synthesis of carboxyalkylthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity.
    Farmaco (Societa chimica italiana : 1989), 1992, Volume: 47, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Edema; Lethal Dose 50; Mice; Pain Measurement; Rats; Structure-Activity Relationship; Superoxides; Thiazoles; Triazoles

1992
Characterization of the antagonist activity of the PAF antagonists RP 59227 and WEB 2086 on elicited guinea pig peritoneal macrophages. Evidence for variable affinities and kinetics.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:3

    Topics: Animals; Azepines; Guinea Pigs; Humans; Kinetics; Macrophages; Male; Neutrophils; Peritoneum; Platelet Activating Factor; Pyridines; Superoxides; Thiazoles; Triazoles

1992
Synthesis and biological activity of new heterocyclic structures: [1,3]thiazino[2,3-i]purine, thiazolo[3,2-c] [1,2,3]triazolo[4,5-e]pyrimidine and [1,2,3]triazolo [4', 5': 4,5] pyrimido[6,1-b][1,3]thiazine.
    Farmaco (Societa chimica italiana : 1989), 1992, Volume: 47, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Antiviral Agents; Bacteria; Fungi; Isomerism; Microbial Sensitivity Tests; Purines; Pyrimidines; Thiazines; Thiazoles; Triazoles; Vero Cells; Viral Plaque Assay; Viruses

1992
Lack of enantio-selectivity in the in vitro antitumour cytotoxicity and membrane-damaging activity of ether lipid SRI 62-834: further evidence for a non-receptor-mediated mechanism of action.
    Biochemical pharmacology, 1992, Aug-18, Volume: 44, Issue:4

    Topics: Antineoplastic Agents; Azepines; Cell Death; Cell Membrane; Furans; Humans; Phospholipid Ethers; Platelet Aggregation Inhibitors; Stereoisomerism; Tetrazolium Salts; Thiazoles; Triazoles; Tumor Cells, Cultured

1992
Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor.
    Scandinavian journal of gastroenterology, 1992, Volume: 27, Issue:2

    Topics: Animals; Azepines; Blood Pressure; Burns; Gastric Mucosa; Hemodynamics; Hemoglobins; Male; Oxygen; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Regional Blood Flow; Thiazoles; Thiazolidines; Triazoles

1992
RP 59227, a novel PAF receptor antagonist: effects in guinea pig models of airway hyperreactivity.
    European journal of pharmacology, 1992, Jan-07, Volume: 210, Issue:1

    Topics: Animals; Antigens; Azepines; Bronchial Hyperreactivity; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Guinea Pigs; Male; Ovalbumin; Platelet Activating Factor; Pyridines; Thiazoles; Triazoles

1992
Benzo[b]thiophenes, Part I: Synthesis and antimicrobial activity of benzo[b]thienyl-1,3,4-oxadiazole, -1,2,4-triazoline, and -thiazoline derivatives.
    Archiv der Pharmazie, 1992, Volume: 325, Issue:2

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida albicans; Microbial Sensitivity Tests; Oxadiazoles; Thiazoles; Thiophenes; Triazoles

1992
The platelet activating factor receptor antagonist, RP 59227, blocks platelet activating factor receptors mediating liberation of reactive oxygen species in guinea pig macrophages and human polymorphonuclear leukocytes.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2

    Topics: Animals; Azepines; Glyceryl Ethers; Guinea Pigs; Humans; Luminescent Measurements; Macrophages; Male; Neutrophils; Oxygen; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles

1991
Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:1

    Topics: Animals; Azepines; Blood Platelets; Bronchoconstriction; Guinea Pigs; Humans; Injections, Intravenous; Leukopenia; Male; Mice; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thrombocytopenia; Triazoles

1991
Pharmacological properties of YM461, a new orally active platelet-activating factor antagonist.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Administration, Oral; Animals; Azepines; Blood Platelets; Blood Pressure; Cell Membrane; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles

1991
Ro 19-3704 directly inhibits immunoglobulin E-dependent mediator release by a mechanism independent of its platelet-activating factor antagonist properties.
    European journal of pharmacology, 1990, Feb-13, Volume: 176, Issue:3

    Topics: Animals; Azepines; Diterpenes; Ginkgolides; Glyceryl Ethers; Histamine Release; Humans; Immunoglobulin E; Inositol Phosphates; L-Lactate Dehydrogenase; Lactones; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Substance P; Synovial Fluid; Thiazoles; Triazines; Triazoles; Tumor Cells, Cultured

1990
Protective effect of SR 27417, a novel PAF antagonist, on lethal anaphylactic and endotoxin-induced shock in mice.
    European journal of pharmacology, 1991, Dec-03, Volume: 205, Issue:3

    Topics: Anaphylaxis; Animals; Azepines; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Male; Mice; Mice, Inbred Strains; Ovalbumin; Platelet Activating Factor; Shock, Septic; Thiazoles; Triazoles

1991
Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Animals; Azepines; Diterpenes; Female; Gangliosides; Ginkgolides; In Vitro Techniques; Kidney; Kinetics; Lactones; Male; Perfusion; Platelet Activating Factor; Pyridines; Rabbits; Renal Circulation; Tachyphylaxis; Thiazoles; Time Factors; Triazoles

1991
Platelet-leukocyte interaction in adhesion to endothelial cells induced by platelet-activating factor in vitro.
    British journal of pharmacology, 1991, Volume: 103, Issue:2

    Topics: Adenine; Animals; Azepines; Blood Platelets; Cell Adhesion; Diterpenes; Endothelium, Vascular; Female; Ginkgolides; Humans; In Vitro Techniques; Lactones; Leukocytes; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Pregnancy; Rabbits; Thiazoles; Triazoles; Umbilical Veins

1991
PAF-induced conjunctivitis in the rabbit is mediated by peptido-leukotrienes.
    Journal of ocular pharmacology, 1990,Fall, Volume: 6, Issue:3

    Topics: Animals; Azepines; Conjunctiva; Conjunctivitis; Cyclooxygenase Inhibitors; Dicarboxylic Acids; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indomethacin; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; Second Messenger Systems; Tetrazoles; Thiazoles; Thienopyridines; Triazoles

1990
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
    Biochemical and biophysical research communications, 1991, Apr-30, Volume: 176, Issue:2

    Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Male; Metabolic Clearance Rate; Methylprednisolone; Piperazines; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Ticlopidine; Triazoles

1991
Characterization of receptors for platelet-activating factor in guinea pig lung membranes.
    American journal of respiratory cell and molecular biology, 1990, Volume: 3, Issue:3

    Topics: Animals; Azepines; Cell Membrane; Female; Guinea Pigs; Kinetics; Lung; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles

1990
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
    Cancer research, 1990, Dec-01, Volume: 50, Issue:23

    Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil

1990
Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Benzhydryl Compounds; Chemical Phenomena; Chemistry; Female; Gonadotropins, Equine; Imidazoles; Microsomes; Molecular Structure; NADP; Ovary; Pyrazoles; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship; Thiazoles; Triazoles; X-Ray Diffraction

1990
[Synthetic cephalosporins. IV. Synthesis and antibacterial activity of 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(O-substituted oxyimino)acetamido]-3-(1,2,3-triazol-1-yl)methyl-3-cephem-4-carboxylic acid and related compounds].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1989, Volume: 109, Issue:12

    Topics: Animals; Bacteria; Cephalosporins; Drug Resistance, Microbial; Mice; Structure-Activity Relationship; Thiazoles; Triazoles

1989
[Reactivity of 3-aryl-4-amino-5-mercapto-4H-1,2,4-triazoles: synthesis and biological evaluation of 3,6-diaryl derivatives of 7H-1,2,4-thiazole[3,4-b][1,3,4]thiadiazines, of 3-aryl-4-amino-5-carboxymethylthio-4H-1,2,4-triazoles].
    Il Farmaco; edizione scientifica, 1987, Volume: 42, Issue:7

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Male; Mice; Microbial Sensitivity Tests; Rats; Rats, Inbred Strains; Superoxides; Thiadiazines; Thiazines; Thiazoles; Triazoles

1987
The antisecretory profile of action of the H2-receptor antagonists, famotidine, loxtidine, ranitidine and L-643,441 on the rat isolated gastric mucosa.
    Agents and actions, 1987, Volume: 20, Issue:1-2

    Topics: Animals; Bucladesine; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Methacholine Chloride; Methacholine Compounds; Ranitidine; Rats; Thiadiazoles; Thiazoles; Triazoles

1987
Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan.
    British journal of pharmacology, 1989, Volume: 96, Issue:2

    Topics: Animals; Azepines; Carrageenan; Leukocyte Count; Male; Platelet Activating Factor; Pleurisy; Pyridines; Rats; Rats, Inbred Strains; Thiazoles; Triazines; Triazoles; Zymosan

1989
A new bithiazole derivative with intercalative properties.
    Journal of biomolecular structure & dynamics, 1986, Volume: 4, Issue:2

    Topics: Animals; Cattle; Chemical Phenomena; Chemistry; DNA; Hot Temperature; Intercalating Agents; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Thiazoles; Thymus Gland; Triazoles

1986
Radioligand binding of antagonists of platelet-activating factor to intact human platelets.
    FEBS letters, 1988, Feb-15, Volume: 228, Issue:2

    Topics: Azepines; Binding Sites; Binding, Competitive; Blood Platelets; Humans; Kinetics; Platelet Activating Factor; Pyridines; Thiazoles; Triazines; Triazoles; Tritium

1988
First enzyme of histidine biosynthesis and repression control of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium.
    Journal of bacteriology, 1974, Volume: 120, Issue:1

    Topics: Amino Acids; Amino Acyl-tRNA Synthetases; Carbon Radioisotopes; Cell-Free System; Enzyme Repression; Histidine; Leucine; Mutation; Operon; Salmonella typhimurium; Thiazoles; Triazoles

1974
[Studies on thiocyanation of heterocyclic compounds. IV. Syntheses of imidazo-(2,1-b)-1,3,4-thiadiazole and thiazolo(3,2-b)-s-triazole derivatives, and thiocyanation and bromination of their compounds].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:8

    Topics: Bromine; Chemical Phenomena; Chemistry; Imidazoles; Thiazoles; Triazoles

1972
Radiation chemistry of nitrogen and sulfur heterocyclics.
    Radiation research, 1973, Volume: 56, Issue:1

    Topics: Chromatography, Gas; Free Radicals; Heterocyclic Compounds; Imidazoles; Nitrogen; Pyrazines; Pyrazoles; Pyrimidines; Pyrroles; Radiochemistry; Sulfur; Tetrazoles; Thiazoles; Thiophenes; Triazines; Triazoles

1973
Bicyclic triazoles. 1. 3-(2-Furyl)-5-phenylthiazolo-2,3-c)-s-triazole.
    Journal of medicinal chemistry, 1972, Volume: 15, Issue:3

    Topics: Animals; Blood Pressure; Bridged-Ring Compounds; Furans; Male; Rats; Rats, Inbred Strains; Stimulation, Chemical; Thiazoles; Triazoles

1972
Synthesis and activity of some 1,2,4-triazolylthiazolidones.
    Journal of medicinal chemistry, 1971, Volume: 14, Issue:1

    Topics: Antiviral Agents; Chemical Phenomena; Chemistry; Thiazoles; Triazoles

1971
Pteridines. 8. Some 2,4,7-triamino-6-heteroarylpteridines.
    Journal of medicinal chemistry, 1968, Volume: 11, Issue:3

    Topics: Chromatography, Paper; Furans; Hydrogen-Ion Concentration; Imidazoles; Oxazoles; Pteridines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Spectrum Analysis; Thiazoles; Thiophenes; Triazoles; Ultraviolet Rays

1968
Steroids 23. Synthesis fo some ring A-fused heterocyclic steroids.
    Journal of pharmaceutical sciences, 1965, Volume: 54, Issue:8

    Topics: Anabolic Agents; Chemical Phenomena; Chemistry; Heterocyclic Compounds; Imidazoles; Oxazoles; Pyrazoles; Thiazoles; Triazoles

1965
Derivatives of imidazole. II. Synthesis and reactions of imidazo[1,2-alpha]pyrimidines and other bi- and tricyclic imidazo derivatives with analgesic, antiinflammatory, antipyretic, and anticonvulsant activity.
    Journal of medicinal chemistry, 1966, Volume: 9, Issue:1

    Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Aspirin; Chemistry, Organic; Electrophysiology; Imidazoles; Mice; Organic Chemistry Phenomena; Phenylbutazone; Pyridazines; Pyrimidines; Rats; Thiazoles; Triazoles

1966
The PETT series, a new class of potent nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:6

    Topics: Animals; Antiviral Agents; Base Sequence; Benzodiazepines; Brain; Cattle; Cells, Cultured; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; HIV-1; Humans; Imidazoles; Intercalating Agents; Male; Molecular Sequence Data; Pyridines; Rats; Rats, Inbred F344; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Thiourea; Triazoles

1995
Platelet-activating factor stimulates gastric acid secretion in isolated rabbit gastric glands.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1

    Topics: Aminopyrine; Animals; Azepines; Biological Transport; Calcium; Carbachol; Dose-Response Relationship, Drug; Egtazic Acid; Famotidine; Fluorescent Dyes; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Rabbits; Thiazoles; Thienopyridines; Triazoles; Verapamil

1995
Synthesis and biological activities of some 3,6-disubstituted thiazolo[3,2-b][1,2,4]triazoles.
    Journal of pharmaceutical sciences, 1995, Volume: 84, Issue:4

    Topics: Animals; Anticonvulsants; Antifungal Agents; Candida; Electroshock; Male; Mice; Microbial Sensitivity Tests; Pentylenetetrazole; Seizures; Spectrophotometry, Infrared; Thiazoles; Triazoles

1995
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.
    Journal of medicinal chemistry, 1995, Sep-01, Volume: 38, Issue:18

    Topics: Animals; Azepines; Benzodiazepines; Imidazoles; Mice; Platelet Activating Factor; Pyridines; Rabbits; Structure-Activity Relationship; Thiazoles; Triazoles

1995
Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones as potential platelet aggregation inhibitors.
    Archiv der Pharmazie, 1995, Volume: 328, Issue:2

    Topics: Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Thiazoles; Triazoles

1995
Yangambin: a new naturally-occurring platelet-activating factor receptor antagonist: in vivo pharmacological studies.
    Planta medica, 1995, Volume: 61, Issue:2

    Topics: Animals; Antihypertensive Agents; Azepines; Blood Platelets; Female; Furans; Heart Rate; Leukocytes; Lignans; Male; Plants; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles

1995
The role of platelet-activating factor in lipopolysaccharide-induced myocardial depression in guinea pigs.
    Journal of critical care, 1995, Volume: 10, Issue:1

    Topics: Animals; Azepines; Depression, Chemical; Drug Interactions; Escherichia coli; Female; Guinea Pigs; Isoproterenol; Lipopolysaccharides; Male; Myocardial Contraction; Phenylephrine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Time Factors; Triazoles

1995
Synthesis of some 4-thiazoline and 4H-1,2,4-triazole derivatives of imidazo[1,2-a]pyridine as possible anticonvulsants.
    Farmaco (Societa chimica italiana : 1989), 1994, Volume: 49, Issue:10

    Topics: Animals; Anticonvulsants; Magnetic Resonance Spectroscopy; Pyridines; Rats; Rats, Sprague-Dawley; Thiazoles; Triazoles

1994
Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils.
    European journal of pharmacology, 1994, Nov-15, Volume: 269, Issue:3

    Topics: Animals; Azepines; Binding, Competitive; Calcium; Cell Count; Cell Degranulation; Chemotaxis, Leukocyte; Free Radical Scavengers; Inositol 1,4,5-Trisphosphate; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Standards; Signal Transduction; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines; Triazoles; Vitamin E

1994
Effect of platelet activating factor antagonists in different models of thrombosis.
    Thrombosis research, 1994, Dec-15, Volume: 76, Issue:6

    Topics: Animals; Arterial Occlusive Diseases; Azepines; Cats; Diterpenes; Ginkgolides; Lactones; Male; Mice; Mice, Inbred Strains; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thiazoles; Thrombophlebitis; Triazoles

1994
The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs.
    Auris, nasus, larynx, 1993, Volume: 20, Issue:3

    Topics: Airway Resistance; Animals; Azepines; Chromones; Guinea Pigs; Histamine H1 Antagonists; Immunization; Lipoxygenase Inhibitors; Male; Ovalbumin; Phthalazines; Platelet Activating Factor; Pyrilamine; Rhinitis, Allergic, Perennial; Sneezing; SRS-A; Thiazoles; Thiazolidines; Triazoles

1993
Endothelial cell-associated platelet-activating factor primes neutrophils for enhanced superoxide production and arachidonic acid release during adhesion to but not transmigration across IL-1 beta-treated endothelial monolayers.
    Journal of immunology (Baltimore, Md. : 1950), 1994, Oct-15, Volume: 153, Issue:8

    Topics: Arachidonic Acid; Azepines; Cell Adhesion; Cell Movement; Cell Polarity; Endothelium, Vascular; Humans; In Vitro Techniques; Interleukin-1; Neutrophil Activation; Neutrophils; Piperazines; Platelet Activating Factor; Superoxides; Thiazoles; Thiazolidines; Triazoles

1994
Preparation of C-(2-deoxyhex/pent-1-enopyranosyl)heterocycles.
    Carbohydrate research, 1994, Feb-17, Volume: 254

    Topics: Cyanides; Glycosides; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleosides; Optical Rotation; Oxadiazoles; Solvents; Stereoisomerism; Thiazoles; Triazoles

1994
Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist.
    Journal of lipid mediators, 1993, Volume: 8, Issue:1

    Topics: Animals; Antioxidants; Azepines; Blood Glucose; Blood Platelets; Cattle; Diabetes Mellitus, Experimental; Free Radical Scavengers; Humans; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Mitochondria, Heart; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Superoxides; Sympathomimetics; Thiazoles; Thiobarbituric Acid Reactive Substances; Triazoles

1993
Synthesis and vasodilatory activity of some thiazolo-triazole derivative.
    Farmaco (Societa chimica italiana : 1989), 1993, Volume: 48, Issue:5

    Topics: Animals; Muscle, Smooth, Vascular; Sheep; Structure-Activity Relationship; Thiazoles; Triazoles; Vasodilation; Vasodilator Agents

1993
Mechanism and regulation of neutrophil priming by platelet-activating factor.
    Journal of cellular physiology, 1993, Volume: 156, Issue:1

    Topics: Adult; Amiloride; Azepines; Calcium; Chelating Agents; Diacylglycerol Kinase; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphotransferases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyrimidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Thiazoles; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella

1993
Platelet-activating factor and the vascular effects of zymosan in rats.
    European journal of pharmacology, 1993, Feb-09, Volume: 231, Issue:2

    Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Female; Hematocrit; Hemodynamics; Iodine Radioisotopes; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Triazoles; Zymosan

1993
Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:4

    Topics: Animals; Azepines; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Diseases; Intestinal Mucosa; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Thiazoles; Triazoles

1996
Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils.
    British journal of pharmacology, 1996, Volume: 117, Issue:5

    Topics: Azepines; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Endothelium, Vascular; Ginkgolides; Humans; Lactones; Leukocyte Elastase; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles

1996
In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:10

    Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Cryptococcosis; Female; Fluconazole; Fungi; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Thiazoles; Triazoles

1996
Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis, and cryptococcosis.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:10

    Topics: Animals; Antifungal Agents; Aspergillosis; Brain Diseases; Candidiasis; Candidiasis, Oral; Cryptococcosis; Female; Fluconazole; Lung Diseases, Fungal; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Rats; Rats, Sprague-Dawley; Thiazoles; Triazoles

1996
Progress report on new antiepileptic drugs: a summary of the Third Eilat Conference.
    Epilepsy research, 1996, Volume: 25, Issue:3

    Topics: Acetamides; Animals; Anticonvulsants; Azetidines; Carbamates; Drug Evaluation, Preclinical; Drugs, Investigational; Epilepsy; Humans; Israel; Levetiracetam; Nipecotic Acids; Phenylenediamines; Piracetam; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Thiazoles; Tiagabine; Triazoles

1996
Species differences in PAF receptor binding in the lungs between hamster and guinea pig.
    Journal of lipid mediators and cell signalling, 1997, Volume: 16, Issue:2

    Topics: Animals; Azepines; Binding, Competitive; Cricetinae; Fibrinolytic Agents; Guinea Pigs; Kinetics; Ligands; Lung; Male; Mesocricetus; Organophosphorus Compounds; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Triazoles

1997
Synthesis and antifungal activity of novel thiazole-containing triazole antifungals.
    Chemical & pharmaceutical bulletin, 1997, Volume: 45, Issue:7

    Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Candida; Candidiasis; Mice; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Structure-Activity Relationship; Thiazoles; Triazoles

1997
Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines.
    Die Pharmazie, 1997, Volume: 52, Issue:8

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Candida albicans; Escherichia coli; Microbial Sensitivity Tests; Quinoxalines; Staphylococcus aureus; Thiazoles; Triazoles

1997
Assay for toxic chemicals using bacteria.
    Bulletin of environmental contamination and toxicology, 1997, Volume: 59, Issue:6

    Topics: Bacteria; Coloring Agents; Culture Media; Minerals; Oxidation-Reduction; Platelet Aggregation Inhibitors; Rhizobium; Tetrazolium Salts; Thiazoles; Toxicity Tests; Triazoles

1997
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Neutrophils; P-Selectin; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles

1998
In vitro activity of a new oral triazole, BMS-207147 (ER-30346)
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:2

    Topics: Amphotericin B; Antifungal Agents; Candida; Cryptococcus; Microbial Sensitivity Tests; Thiazoles; Triazoles

1998
Synthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives.
    Chemical & pharmaceutical bulletin, 1998, Volume: 46, Issue:4

    Topics: Animals; Antifungal Agents; Candidiasis; Culture Media; Fungi; Mice; Microbial Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles

1998
New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol.
    Journal of medicinal chemistry, 1998, May-21, Volume: 41, Issue:11

    Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candidiasis; Colony Count, Microbial; Fungi; Male; Mice; Molecular Conformation; Pyrimidinones; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles

1998
Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.
    The Journal of biological chemistry, 1998, Jun-05, Volume: 273, Issue:23

    Topics: Androstadienes; Animals; Azepines; Cell Adhesion Molecules; Cell Movement; Chromones; Colonic Neoplasms; Dogs; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Genes, src; GTP-Binding Proteins; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Kidney; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Thiazoles; Transformation, Genetic; Triazoles; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin

1998
In vitro susceptibilities of Candida bloodstream isolates to the new triazole antifungal agents BMS-207147, Sch 56592, and voriconazole.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:12

    Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole

1998
Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
    Bioorganic & medicinal chemistry letters, 1998, Jun-16, Volume: 8, Issue:12

    Topics: Anti-HIV Agents; Blood Proteins; Cell Line; HIV-1; Humans; Microbial Sensitivity Tests; Protein Binding; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Triazoles

1998
Colorimetric MTT assessment of antifungal activity of D0870 against fluconazole-resistant Candida albicans.
    Mycoses, 1998, Volume: 41, Issue:11-12

    Topics: Antifungal Agents; Candida albicans; Candidiasis; Colorimetry; Drug Resistance, Microbial; Fluconazole; Humans; Microbial Sensitivity Tests; Tetrazolium Salts; Thiazoles; Triazoles

1998
In vitro susceptibilities of Candida dubliniensis isolates tested against the new triazole and echinocandin antifungal agents.
    Journal of clinical microbiology, 1999, Volume: 37, Issue:3

    Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Candida; Candidiasis; Caspofungin; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

1999
Effects of histamine H2 receptor agonists and antagonists on the isolated guinea pig gallbladder.
    Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:1

    Topics: Animals; Benzothiazoles; Dopamine Agents; Famotidine; Gallbladder; Guanidines; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Phenoxypropanolamines; Piperidines; Pyridines; Receptors, Histamine H2; Sincalide; Thiazoles; Triazoles

1999
3-Cyclopropyl-1,2,4-triazolo[3,4-b]benzothiazole monohydrate.
    Acta crystallographica. Section C, Crystal structure communications, 1999, Jul-15, Volume: 55 ( Pt 7)

    Topics: Benzothiazoles; Crystallization; Crystallography, X-Ray; Hydrogen Bonding; Molecular Structure; Thiazoles; Triazoles

1999
In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:9

    Topics: Antifungal Agents; Candida; Dose-Response Relationship, Drug; Fluconazole; Humans; Itraconazole; Latin America; Microbial Sensitivity Tests; North America; Population Surveillance; Thiazoles; Triazoles

1999
Augmentation of ultraviolet B radiation-induced tumor necrosis factor production by the epidermal platelet-activating factor receptor.
    The Journal of biological chemistry, 1999, Sep-17, Volume: 274, Issue:38

    Topics: Azepines; Cells, Cultured; Humans; Indoles; Keratinocytes; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Thiazoles; Triazoles; Tumor Necrosis Factor-alpha; Ultraviolet Rays; Vitamin E

1999
ER 30346. BMS 207147.
    Drugs in R&D, 1999, Volume: 1, Issue:2

    Topics: Animals; Antifungal Agents; Dogs; Drug Interactions; Drugs, Investigational; Fungi; Humans; Mycoses; Rats; Thiazoles; Triazoles

1999
In vitro antifungal activity of BMS-207147 and itraconazole against yeast strains that are non-susceptible to fluconazole.
    Diagnostic microbiology and infectious disease, 1999, Volume: 35, Issue:2

    Topics: Antifungal Agents; Candida; Drug Resistance, Microbial; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Thiazoles; Triazoles

1999
Synthesis and evaluation of anti-inflammatory activity of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their Michael addition products.
    Arzneimittel-Forschung, 1999, Volume: 49, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Magnetic Resonance Spectroscopy; Male; Mice; Stomach Ulcer; Thiazoles; Triazoles

1999
In vitro activity of the new triazole BMS-207147 against Aspergillus species in comparison with itraconazole and amphotericin B.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:2

    Topics: Amphotericin B; Antifungal Agents; Aspergillus; Drug Resistance, Microbial; Humans; Itraconazole; Microbial Sensitivity Tests; Thiazoles; Triazoles

2000
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
    The Journal of biological chemistry, 2000, Feb-25, Volume: 275, Issue:8

    Topics: Binding, Competitive; Crystallography, X-Ray; Deoxyguanine Nucleotides; DNA Primers; Dose-Response Relationship, Drug; HIV Reverse Transcriptase; Inhibitory Concentration 50; Intercalating Agents; Kinetics; Models, Chemical; Models, Molecular; Protein Binding; Pyridines; Regression Analysis; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thiazoles; Thiourea; Triazoles

2000
Synthesis and biological evaluation of indole containing derivatives of thiosemicarbazide and their cyclic 1,2,4-triazole and 1,3,4-thiadiazole analogs.
    Arzneimittel-Forschung, 2000, Volume: 50, Issue:1

    Topics: Anti-Infective Agents; Antifungal Agents; Antiviral Agents; Bacteriophages; Lipids; Microbial Sensitivity Tests; Semicarbazides; Structure-Activity Relationship; Thiazoles; Triazoles

2000
Interferon-gamma-induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis.
    Blood, 2000, Apr-01, Volume: 95, Issue:7

    Topics: Adult; Azepines; Calcium; Cell Membrane; Cytotoxicity, Immunologic; Gene Expression; Humans; Interferon-gamma; Killer Cells, Natural; Membrane Glycoproteins; Neoplasms; Perforin; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pore Forming Cytotoxic Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Transfection; Triazoles; Tumor Cells, Cultured

2000
R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:1

    Topics: Animals; Aromatase Inhibitors; Benzothiazoles; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Epidermis; Female; Humans; Hyperplasia; Keratosis; Male; Mice; Ovariectomy; Rats; Rats, Wistar; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Tissue Distribution; Tretinoin; Triazoles; Vagina

2000
In vitro activities of ravuconazole (BMS-207147) against 541 clinical isolates of Cryptococcus neoformans.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:10

    Topics: Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Thiazoles; Triazoles

2000
Efficacies of two new antifungal agents, the triazole ravuconazole and the echinocandin LY-303366, in an experimental model of invasive aspergillosis.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:12

    Topics: Anidulafungin; Animals; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Brain; Disease Models, Animal; Echinocandins; Liver; Lung; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles

2000
NTZ for cryptosporidiosis: larger expanded access; buyers' club/FDA conflict. Food and Drug Administration.
    AIDS treatment news, 1996, Nov-01, Issue:No 258

    Topics: Altruism; Clinical Trials as Topic; Consumer Organizations; Cryptosporidiosis; Drug Industry; Drugs, Investigational; Health Services Accessibility; Humans; Nitro Compounds; Thiazoles; Triazoles; United States; United States Food and Drug Administration

1996
In vitro activities of four novel triazoles against Scedosporium spp.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:7

    Topics: Antifungal Agents; Humans; Microbial Sensitivity Tests; Pyrimidines; Quinazolines; Scedosporium; Thiazoles; Triazoles; Voriconazole

2001
Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities.
    Arzneimittel-Forschung, 2001, Volume: 51, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry, Physical; Edema; Female; Magnetic Resonance Spectroscopy; Male; Mice; Spectrophotometry, Infrared; Stomach Ulcer; Thiazoles; Triazoles

2001
International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surv
    Journal of clinical microbiology, 2001, Volume: 39, Issue:9

    Topics: Antifungal Agents; Candida; Candidiasis; Europe; Fluconazole; Fungemia; Humans; Latin America; North America; Pyrimidines; Sentinel Surveillance; Thiazoles; Triazoles; Voriconazole

2001
Efficacy of ravuconazole in treatment of mucosal candidosis in SCID mice.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:12

    Topics: Administration, Oral; Animals; Antifungal Agents; Candidiasis, Chronic Mucocutaneous; Digestive System; Dose-Response Relationship, Drug; Female; Mice; Mice, SCID; Microbial Sensitivity Tests; Thiazoles; Triazoles

2001
Synthesis and evaluation of new triazolobenzothiazole derivatives as potential anti-tubercular agents.
    Arzneimittel-Forschung, 2001, Volume: 51, Issue:11

    Topics: Antitubercular Agents; Chemical Phenomena; Chemistry, Physical; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Spectrophotometry, Infrared; Thiazoles; Triazoles

2001
Efficacy of ravuconazole (BMS-207147) in a guinea pig model of disseminated aspergillosis.
    The Journal of antimicrobial chemotherapy, 2002, Volume: 49, Issue:2

    Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Male; Organ Culture Techniques; Organ Specificity; Thiazoles; Triazoles

2002
Efficacy of ravuconazole in treatment of systemic murine histoplasmosis.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:3

    Topics: Animals; Antifungal Agents; Colony Count, Microbial; Female; Fluconazole; Histoplasmosis; Itraconazole; Liver; Mice; Spleen; Survival; Survival Analysis; Thiazoles; Triazoles

2002
Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:4

    Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Canada; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Quality Control; Thiazoles; Triazoles; United States; Voriconazole

2002
Penetration of ravuconazole, a new triazole antifungal, into rat tissues.
    Chemotherapy, 2002, Volume: 48, Issue:1

    Topics: Administration, Oral; Animals; Antifungal Agents; Biological Availability; Female; Half-Life; Lung; Rats; Specific Pathogen-Free Organisms; Thiazoles; Triazoles; Uterus

2002
Clinical evaluation of a frozen commercially prepared microdilution panel for antifungal susceptibility testing of seven antifungal agents, including the new triazoles posaconazole, ravuconazole, and voriconazole.
    Journal of clinical microbiology, 2002, Volume: 40, Issue:5

    Topics: Antifungal Agents; Candida; Freezing; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
In vitro activities of ravuconazole and voriconazole compared with those of four approved systemic antifungal agents against 6,970 clinical isolates of Candida spp.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:6

    Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
In vitro activity of three new triazoles and one echinocandin against Candida bloodstream isolates from cancer patients.
    The Journal of antimicrobial chemotherapy, 2002, Volume: 50, Issue:1

    Topics: Antifungal Agents; Blood; Candida; Candidiasis; Echinocandins; Humans; In Vitro Techniques; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Neoplasms; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2002
Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
    Anti-cancer drugs, 2002, Volume: 13, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; CD11c Antigen; CD4 Antigens; Cell Cycle; Cell Differentiation; Diacylglycerol Kinase; Enzyme Activators; Enzyme Inhibitors; Farnesol; Flow Cytometry; Genes, fos; Genes, jun; Humans; Immunoblotting; Isoenzymes; Leukemia, Myeloid; Naphthalenes; Oncogene Protein p21(ras); Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Sulfonamides; Thiazoles; Triazoles; Tumor Cells, Cultured

2002
Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals.
    Bioorganic & medicinal chemistry letters, 2002, Oct-07, Volume: 12, Issue:19

    Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Azoles; Candida albicans; Candidiasis; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Prodrugs; Rats; Solubility; Thiazoles; Triazoles

2002
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease.
    International journal of antimicrobial agents, 2003, Volume: 21, Issue:1

    Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Mice; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2003
In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis model.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:4

    Topics: Animals; Antifungal Agents; Area Under Curve; Candidiasis; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Thiazoles; Triazoles

2003
Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin.
    The Journal of infectious diseases, 2003, Jun-15, Volume: 187, Issue:12

    Topics: Animals; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Female; Lipopeptides; Lipoproteins; Lung; Lung Diseases, Fungal; Micafungin; Organ Size; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles

2003
Patterning of motor neurons by retinoic acid in the chick embryo hindbrain in vitro.
    Molecular and cellular neurosciences, 2003, Volume: 23, Issue:1

    Topics: Animals; Antineoplastic Agents; Benzothiazoles; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endoderm; Gene Expression Regulation, Developmental; Homeodomain Proteins; In Situ Hybridization; In Vitro Techniques; LIM-Homeodomain Proteins; Mesoderm; Motor Neurons; Nerve Tissue Proteins; Retinoic Acid 4-Hydroxylase; Rhombencephalon; Thiazoles; Transcription Factors; Tretinoin; Triazoles

2003
Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi.
    Journal of clinical microbiology, 2003, Volume: 41, Issue:8

    Topics: Amphotericin B; Anti-Bacterial Agents; Aspergillus; Caspofungin; Echinocandins; Fungi; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Penicillium; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2003
Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2,4-triazole)Ru(III) complexes.
    Inorganic chemistry, 2003, Sep-22, Volume: 42, Issue:19

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Organometallic Compounds; Ruthenium; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles; Triazoles

2003
Use of mercurated thiazoles as fungistatic agents.
    Nature, 1954, Sep-11, Volume: 174, Issue:4428

    Topics: Antifungal Agents; Fungicides, Industrial; Humans; Thiazoles; Triazoles

1954
EFFECT ON CATALASE IN VIVO AND IN VITRO OF COMPOUNDS RELATED TO AMINOTRIAZOLE. ANL-6823.
    ANL, 1964

    Topics: Amitrole; Azides; Azoles; Catalase; Enzyme Inhibitors; Erythrocytes; Imidazoles; In Vitro Techniques; Isoniazid; Kidney; Liver; Oxadiazoles; Oxazoles; Oxidation-Reduction; Pentylenetetrazole; Pharmacology; Pyrazoles; Rats; Research; Thiazoles; Triazoles

1964
BETA-HYDROXYPHENETHYLAMINO DERIVATIVES OF VARIOUS NITROGEN HETEROCYCLES.
    Journal of medicinal chemistry, 1964, Volume: 7

    Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antipyretics; Chemistry, Pharmaceutical; Hypnotics and Sedatives; Muscle Relaxants, Central; Nitrogen; Pharmacology; Phenethylamines; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Research; Thiazoles; Triazines; Triazoles

1964
HETEROCYCLIC STEROIDS IN THE ANTIINFLAMMATORY SERIES.
    Journal of medicinal chemistry, 1964, Volume: 7

    Topics: Anti-Inflammatory Agents; Chemistry, Pharmaceutical; Imidazoles; Inflammation; Pharmacology; Pyrazoles; Pyrimidines; Research; Steroids; Steroids, Heterocyclic; Thiazoles; Triazoles

1964
In vitro activities of new antifungal agents against Chaetomium spp. and inoculum standardization.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:10

    Topics: Antifungal Agents; Chaetomium; Colony Count, Microbial; Humans; Microbial Sensitivity Tests; Mitosporic Fungi; Pyrimidines; Reference Standards; Thiazoles; Triazoles; Voriconazole

2003
Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties.
    Bioorganic & medicinal chemistry letters, 2003, Nov-03, Volume: 13, Issue:21

    Topics: Animals; Antifungal Agents; Candidiasis; Drug Stability; Female; Humans; Indicators and Reagents; Infusions, Intravenous; Mice; Mice, Inbred ICR; Prodrugs; Rats; Solubility; Structure-Activity Relationship; Survival; Thiazoles; Triazoles

2003
Synthesis of some functionalized arylaminomethyl-1 ,2,4-triazoles, 1,3,4-oxa- and thiadiazoles.
    Die Pharmazie, 2003, Volume: 58, Issue:11

    Topics: Antiviral Agents; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Hepatitis B virus; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methylation; Oxazoles; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Triazoles

2003
Synthesis and in vitro antibacterial evaluation of novel imidazo[2',1':5,1]-1,2,4-triazolo[4,3-c]-quinazoline derivatives of 5-thioxo-1, 2, 4-triazole, 4-oxothiazolidine, and their open-chain counterparts.
    Archiv der Pharmazie, 2003, Volume: 336, Issue:12

    Topics: Anti-Bacterial Agents; Colony Count, Microbial; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Quinazolines; Quinazolinones; Structure-Activity Relationship; Thiazoles; Triazoles

2003
In vitro activity of ravuconazole against Zygomycetes, Scedosporium and Fusarium isolates.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2003, Volume: 9, Issue:12

    Topics: Amphotericin B; Antifungal Agents; Fungi; Fusarium; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Scedosporium; Thiazoles; Triazoles; Voriconazole

2003
Facile syntheses of oxazolines and thiazolines with N-acylbenzotriazoles under microwave irradiation.
    The Journal of organic chemistry, 2004, Feb-06, Volume: 69, Issue:3

    Topics: Microwaves; Oxazoles; Thiazoles; Triazoles

2004
In vitro interactions of licensed and novel antifungal drugs against Fusarium spp.
    Diagnostic microbiology and infectious disease, 2004, Volume: 48, Issue:1

    Topics: Amphotericin B; Antifungal Agents; Drug Interactions; Drug Resistance, Fungal; Fusarium; Humans; Itraconazole; Microbial Sensitivity Tests; Naphthalenes; Pyrimidines; Quinazolines; Sensitivity and Specificity; Terbinafine; Thiazoles; Triazoles; Voriconazole

2004
Studies on the fungistatic powers of a new benzothiazol and an antihistaminic compound.
    Canadian Medical Association journal, 1951, Volume: 65, Issue:6

    Topics: Antifungal Agents; Fungicides, Industrial; Histamine H1 Antagonists; Humans; Thiazoles; Triazoles

1951
Synthesis and evaluation of in vitro antimycobacterial activity of some 5-(5-nitro-2-thienyl)-2-(piperazinyl, piperidinyl and morpholinyl)-1,3,4-thiadiazole derivatives.
    Bollettino chimico farmaceutico, 2003, Volume: 142, Issue:9

    Topics: Antitubercular Agents; Indicators and Reagents; Microbial Sensitivity Tests; Morpholines; Mycobacterium tuberculosis; Piperazines; Piperidines; Thiazoles; Triazoles

2003
In vitro susceptibilities of rare Candida bloodstream isolates to ravuconazole and three comparative antifungal agents.
    Diagnostic microbiology and infectious disease, 2004, Volume: 48, Issue:2

    Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Flucytosine; Fungemia; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles

2004
Synthesis, characterization and antiinflammatory-analgesic properties of 6-(alpha-amino-4-chlorobenzyl)thiazolo [3,2-b]-1,2,4-triazol-5-ols.
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:1

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoquinones; Capillary Permeability; Carrageenan; Chemical Phenomena; Chemistry, Physical; Edema; Foot; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mice; Models, Molecular; Molecular Conformation; Naproxen; Pain; Spectroscopy, Fourier Transform Infrared; Stomach Ulcer; Structure-Activity Relationship; Thiazoles; Triazoles

2004
Efficacy, safety, and plasma pharmacokinetics of escalating dosages of intravenously administered ravuconazole lysine phosphoester for treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:4

    Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Dose-Response Relationship, Drug; Female; Galactose; Half-Life; Image Processing, Computer-Assisted; Immunosuppressive Agents; Injections, Intravenous; Lung; Mannans; Microbial Sensitivity Tests; Neutropenia; Rabbits; Survival Analysis; Tetrazolium Salts; Thiazoles; Tomography, X-Ray Computed; Triazoles

2004
Synthesis and antifungal action of new tricyclazole analogues.
    Journal of agricultural and food chemistry, 2004, Apr-07, Volume: 52, Issue:7

    Topics: Botrytis; Fungicides, Industrial; Microscopy, Electron; Pyrazoles; Structure-Activity Relationship; Thiazoles; Triazoles

2004
Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2.
    Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Naphthyridines; Neoplasm Transplantation; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Transplantation, Heterologous; Triazoles

2004
Computational predictions of stereochemistry in asymmetric thiazolium- and triazolium-catalyzed benzoin condensations.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Apr-20, Volume: 101, Issue:16

    Topics: Benzoin; Catalysis; Models, Molecular; Molecular Structure; Stereoisomerism; Thiazoles; Triazoles

2004
Effect of stereo and regiochemistry towards wild and multidrug resistant HIV-1 virus: viral potency of chiral PETT derivatives.
    Biochemical pharmacology, 2004, May-15, Volume: 67, Issue:10

    Topics: Anti-HIV Agents; Drug Resistance, Multiple; Drug Stability; HIV-1; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles

2004
Synthesis and biological evaluation of novel apio nucleosides with thiazole-4-carboxamide and 1,2,4-triazole-3-carboxamide.
    Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:4

    Topics: Mannose; Nucleosides; Structure-Activity Relationship; Thiazoles; Triazoles

2004
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.
    Journal of virology, 2004, Volume: 78, Issue:14

    Topics: Amino Acid Sequence; Anti-HIV Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thiazoles; Triazoles

2004
Cross-resistance between fluconazole and ravuconazole and the use of fluconazole as a surrogate marker to predict susceptibility and resistance to ravuconazole among 12,796 clinical isolates of Candida spp.
    Journal of clinical microbiology, 2004, Volume: 42, Issue:7

    Topics: Antifungal Agents; Candida; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles

2004
Density functional theory and ab initio studies of geometry, electronic structure and vibrational spectra of novel benzothiazole and benzotriazole herbicides.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2004, Volume: 60, Issue:10

    Topics: Benzothiazoles; Data Interpretation, Statistical; Herbicides; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thiazoles; Triazoles

2004
In vitro activities of ravuconazole and four other antifungal agents against fluconazole-resistant or -susceptible clinical yeast isolates.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:8

    Topics: Antifungal Agents; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles; Yeasts

2004
Effects of several antifungal drug combinations against clinical and environmental isolates of Cryptococcus neoformans from China.
    Mycoses, 2004, Volume: 47, Issue:7

    Topics: Animals; Antifungal Agents; Caspofungin; China; Columbidae; Cryptococcosis; Cryptococcus neoformans; Drug Interactions; Echinocandins; Feces; Flucytosine; Humans; Lipopeptides; Microbial Sensitivity Tests; Naphthalenes; Peptides; Peptides, Cyclic; Terbinafine; Thiazoles; Triazoles

2004
Clinical evaluation of the Sensititre YeastOne colorimetric antifungal plate for antifungal susceptibility testing of the new triazoles voriconazole, posaconazole, and ravuconazole.
    Journal of clinical microbiology, 2004, Volume: 42, Issue:10

    Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Pyrimidines; Reagent Kits, Diagnostic; Thiazoles; Triazoles; Voriconazole

2004
In vitro antifungal susceptibility of Cryptococcus gattii.
    Journal of clinical microbiology, 2004, Volume: 42, Issue:10

    Topics: Antifungal Agents; Cryptococcus; Cryptococcus neoformans; Humans; Microbial Sensitivity Tests; Quinazolines; Thiazoles; Triazoles

2004
Influence of a thiazole derivative on ethanol and thermally oxidized sunflower oil-induced oxidative stress.
    Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:5

    Topics: Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Ethanol; gamma-Glutamyltransferase; Lipid Peroxidation; Liver; Male; Oxidation-Reduction; Oxidative Stress; Plant Oils; Rats; Rats, Wistar; Sunflower Oil; Thiazoles; Triazoles

2004
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.
    Journal of medicinal chemistry, 2005, Mar-24, Volume: 48, Issue:6

    Topics: Administration, Oral; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Hypotension; Hypothermia; Imidazoles; Mice; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles

2005
In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species.
    Medical mycology, 2005, Volume: 43, Issue:2

    Topics: Antifungal Agents; Arthrodermataceae; Fluconazole; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Mycoses; Naphthalenes; Terbinafine; Thiazoles; Triazoles; Yeasts

2005
Redifferentiation of human hepatoma cell induced by 6-(p-chlorophenyl)-3-[1-(p-chlorophenyl)-5-methyl-1 H-1,2,3-triazol-4-yl]-s-triazolo[3,4-b]-1,3,4-thiadiazole (TDZ).
    Die Pharmazie, 2005, Volume: 60, Issue:5

    Topics: alpha-Fetoproteins; Animals; Antineoplastic Agents; Cell Cycle; Cell Differentiation; Cell Survival; DNA, Neoplasm; Electrophoresis; Electrophysiology; Flow Cytometry; Humans; Liver Neoplasms, Experimental; Microscopy, Electron, Scanning; Sarcoma 180; Thiazoles; Thymidine; Triazoles; Tumor Cells, Cultured

2005
Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivatives.
    European journal of medicinal chemistry, 2005, Volume: 40, Issue:6

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Candida; Escherichia coli; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Staphylococcus aureus; Thiazoles; Triazoles

2005
4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system.
    British journal of pharmacology, 2005, Volume: 145, Issue:8

    Topics: Animals; Antineoplastic Agents; Binding Sites; Brain; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Microtubules; Mitotic Index; Protein Binding; Thiazoles; Triazoles; Tubulin

2005
Synthesis and antituberculosis activity of new 3-alkylsulfanyl-1,2,4-triazole derivatives.
    Journal of enzyme inhibition and medicinal chemistry, 2005, Volume: 20, Issue:2

    Topics: Anti-Bacterial Agents; Antitubercular Agents; Chalcones; Culture Media; Microbial Sensitivity Tests; Models, Chemical; Mycobacterium tuberculosis; Oxazines; Temperature; Thiazoles; Triazoles; Xanthenes

2005
In vitro activities of new and established triazoles against opportunistic filamentous and dimorphic fungi.
    Medical mycology, 2005, Volume: 43, Issue:3

    Topics: Antifungal Agents; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Species Specificity; Thiazoles; Triazoles; Voriconazole

2005
Compartmental pharmacokinetics and tissue distribution of the antifungal triazole ravuconazole following intravenous administration of its di-lysine phosphoester prodrug (BMS-379224) in rabbits.
    The Journal of antimicrobial chemotherapy, 2005, Volume: 56, Issue:5

    Topics: Adipose Tissue; Animals; Brain; Half-Life; Injections, Intravenous; Kidney; Liver; Lung; Lysine; Prodrugs; Rabbits; Thiazoles; Tissue Distribution; Triazoles

2005
Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.
    European journal of pharmacology, 2005, Oct-17, Volume: 522, Issue:1-3

    Topics: Algorithms; Analgesics; Animals; Behavior, Animal; Benzothiazoles; Brain; Cimetidine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Injections, Intraventricular; Male; Mice; Molecular Structure; Pain; Pain Measurement; Phenoxypropanolamines; Piperidines; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Triazoles

2005
Advances in antifungal therapy.
    The Pediatric infectious disease journal, 2005, Volume: 24, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anidulafungin; Animals; Antifungal Agents; Caspofungin; Child; Child, Preschool; Clinical Trials as Topic; Echinocandins; Fungal Proteins; Humans; Infant; Infant, Newborn; Lipopeptides; Lipoproteins; Micafungin; Middle Aged; Mycoses; Peptides, Cyclic; Pyrimidines; Thiazoles; Treatment Outcome; Triazoles; Voriconazole

2005
In vitro activity of ravuconazole against 923 clinical isolates of nondermatophyte filamentous fungi.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:12

    Topics: Antifungal Agents; Fungi; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles

2005
Efficient microwave enhanced regioselective synthesis of a series of benzimidazolyl/triazolyl spiro [indole-thiazolidinones] as potent antifungal agents and crystal structure of spiro[3H-indole-3,2'-thiazolidine]-3'(1,2,4-triazol-3-yl)-2,4'(1H)-dione.
    Bioorganic & medicinal chemistry, 2006, Apr-01, Volume: 14, Issue:7

    Topics: Antifungal Agents; Benzimidazoles; Colletotrichum; Crystallization; Fusarium; Indoles; Microwaves; Models, Molecular; Molecular Structure; Rhizoctonia; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidines; Triazoles; X-Ray Diffraction

2006
The design of orally active iron chelators.
    Annals of the New York Academy of Sciences, 2005, Volume: 1054

    Topics: Administration, Oral; Benzoates; Clinical Trials as Topic; Deferasirox; Dihydropyridines; Drug Design; Drug Evaluation, Preclinical; Humans; Iron; Iron Chelating Agents; Ligands; Models, Molecular; Molecular Structure; Oxidation-Reduction; Pyridones; Thiazoles; Triazoles

2005
In vitro activities of new and conventional antimycotics against fluconazole-susceptible and non-susceptible Brazilian Candida spp. isolates.
    Mycoses, 2006, Volume: 49, Issue:3

    Topics: Antifungal Agents; Brazil; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Quinazolines; Thiazoles; Triazoles

2006
Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation.
    The Journal of infectious diseases, 2006, Oct-01, Volume: 194, Issue:7

    Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Drug Antagonism; Drug Therapy, Combination; Humans; Liposomes; Lung Diseases, Fungal; Microbial Sensitivity Tests; Models, Biological; Polyenes; Rabbits; Thiazoles; Triazoles

2006
Antifungal susceptibilities of the species of the Pseudallescheria boydii complex.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:12

    Topics: Amphotericin B; Antifungal Agents; Candida; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Ketoconazole; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Naphthalenes; Peptides, Cyclic; Pseudallescheria; Pyrimidines; Quality Control; Quinazolines; Scedosporium; Terbinafine; Thiazoles; Triazoles; Voriconazole

2006
Multi-azole resistance in Aspergillus fumigatus.
    International journal of antimicrobial agents, 2006, Volume: 28, Issue:5

    Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Caspofungin; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple, Fungal; Echinocandins; Fungal Proteins; Humans; Itraconazole; Lipopeptides; Lung Diseases, Fungal; Male; Microbial Sensitivity Tests; Middle Aged; Mutation, Missense; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2006
Predicting anti-HIV activity of PETT derivatives: CoMFA approach.
    Bioorganic & medicinal chemistry letters, 2007, Apr-15, Volume: 17, Issue:8

    Topics: Anti-HIV Agents; Computational Biology; Drug Design; Humans; Models, Molecular; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Static Electricity; Thiazoles; Thiourea; Triazoles

2007
Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC).
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Animals; Benzimidazoles; Binding, Competitive; Calcium Signaling; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Inositol Phosphates; Male; Mice; Mice, Inbred ICR; Molecular Structure; Motor Activity; Naphthalenes; Point Mutation; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Thiazoles; Transfection; Triazoles

2007
Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats.
    The international journal of neuropsychopharmacology, 2008, Volume: 11, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Alcohol Drinking; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Ethanol; Extinction, Psychological; Glutamic Acid; Models, Animal; Motor Activity; Pyridines; Pyrimidines; Rats; Rats, Inbred Strains; Reaction Time; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Self Administration; Thiazoles; Time Factors; Triazoles; Xanthines

2008
Novel regioselective formation of S- and N-hydroxyl-alkyls of 5-(3-chlorobenzo[b]thien-2-yl)-3-mercapto-4H-1,2,4-triazole and a facile synthesis of triazolo-thiazoles and thiazolo-triazoles. Role of catalyst and microwave.
    Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:5

    Topics: Alkylation; Catalysis; Ethanol; Microwaves; Sodium Acetate; Stereoisomerism; Thiazines; Thiazoles; Triazoles

2007
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
    Journal of medicinal chemistry, 2007, Aug-09, Volume: 50, Issue:16

    Topics: Aminopeptidases; Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Capillaries; Cell Proliferation; Crystallography, X-Ray; Endothelial Cells; Endothelium, Vascular; Furans; In Vitro Techniques; Male; Metalloendopeptidases; Models, Molecular; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles

2007
Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
    Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23

    Topics: Amyloidosis; Benzamides; Benzothiazoles; Cell Line; Cell Survival; Cross-Linking Reagents; Drug Design; Fluorescence; Glutaral; Humans; Kinetics; Models, Molecular; Oxadiazoles; Phenyl Ethers; Prealbumin; Protein Denaturation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Thiazoles; Triazoles; Tryptophan

2007
Selective regulation of neurosteroid biosynthesis in human neuroblastoma cells under hydrogen peroxide-induced oxidative stress condition.
    Neuroscience, 2008, Feb-06, Volume: 151, Issue:3

    Topics: Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Letrozole; Neuroblastoma; Nitriles; Oxidative Stress; Serum; Steroids; Tetrazolium Salts; Thiazoles; Time Factors; Triazoles

2008
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
    Journal of medicinal chemistry, 2008, May-22, Volume: 51, Issue:10

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Adipose Tissue; Animals; Cortisone; Crystallography, X-Ray; Diabetes Mellitus, Type 2; Humans; Hydrocortisone; Hypoglycemic Agents; Ligands; Liver; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles

2008
Antioxidant activity of an aminothiazole compound: possible mechanisms.
    Chemico-biological interactions, 2008, Jun-17, Volume: 173, Issue:3

    Topics: Animals; Antioxidants; DNA; DNA Damage; Female; Free Radical Scavengers; Lipid Peroxidation; Mitochondria, Liver; Molecular Structure; Oxidation-Reduction; Proteins; Rats; Rats, Wistar; Thiazoles; Triazoles

2008
Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7

    Topics: Amino Acid Substitution; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Genes, Fungal; Humans; Itraconazole; Microbial Sensitivity Tests; Molecular Epidemiology; Molecular Sequence Data; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2008
Nonclinical pharmacokinetics of BMS-292655, a water-soluble prodrug of the antifungal ravuconazole.
    Biopharmaceutics & drug disposition, 2008, Volume: 29, Issue:5

    Topics: Animals; Antifungal Agents; Blood Proteins; Dogs; Humans; Hydrolysis; In Vitro Techniques; Macaca fascicularis; Male; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Thiazoles; Triazoles

2008
MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands.
    Biochemical pharmacology, 2008, Jul-15, Volume: 76, Issue:2

    Topics: Anastrozole; Aromatase Inhibitors; Biological Assay; Cell Line, Tumor; Coumarins; ERRalpha Estrogen-Related Receptor; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Fulvestrant; Genes, Reporter; Genistein; Humans; Letrozole; Ligands; Luciferases; Nitriles; Receptors, Estrogen; Response Elements; Tamoxifen; Thiazoles; Transfection; Triazoles

2008
Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives.
    Chemical record (New York, N.Y.), 2008, Volume: 8, Issue:3

    Topics: Animals; Anti-Obesity Agents; CHO Cells; Cricetinae; Cricetulus; Humans; Imidazoles; Isomerism; Models, Chemical; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Solubility; Structure-Activity Relationship; Thiazoles; Triazoles; Water

2008
Synthesis, analgesic, anti-inflammatory and antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:2

    Topics: Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Microbial Sensitivity Tests; Spectrum Analysis; Structure-Activity Relationship; Thiazoles; Triazoles

2009
Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: results of a 3-year (2004 to 2007) surveillance study.
    Journal of clinical microbiology, 2008, Volume: 46, Issue:9

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Caspofungin; Child; Child, Preschool; Echinocandins; Female; Fluconazole; Humans; Infant; Infant, Newborn; Itraconazole; Lipopeptides; Male; Mexico; Microbial Sensitivity Tests; Middle Aged; Pyrimidines; Thiazoles; Triazoles; Voriconazole; Young Adult

2008
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
    Chemical research in toxicology, 2008, Volume: 21, Issue:9

    Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles

2008
Effects of a hindered amine light stabilizer and a UV light absorber used in maxillofacial elastomers on human gingival epithelial cells and fibroblasts.
    The Journal of prosthetic dentistry, 2008, Volume: 100, Issue:3

    Topics: Cell Line; Cell Membrane; Cell Proliferation; Cell Survival; Colorimetry; Coloring Agents; Decanoic Acids; Epithelial Cells; Fibroblasts; Gingiva; Humans; L-Lactate Dehydrogenase; Materials Testing; Maxillofacial Prosthesis; Piperidines; Silicone Elastomers; Spectrophotometry; Tetrazolium Salts; Thiazoles; Time Factors; Triazoles

2008
Synthesis, antibacterial and antifungal activities of 3-(1,2,4-triazol-3-yl)-4-thiazolidinones.
    Journal of enzyme inhibition and medicinal chemistry, 2009, Volume: 24, Issue:2

    Topics: Anti-Bacterial Agents; Antifungal Agents; Microbial Sensitivity Tests; Schiff Bases; Sulfhydryl Compounds; Thiazoles; Thioglycolates; Triazoles

2009
First synthesis of non-symmetrical "phthalimidoyl active ester" bi-dentate cross-linking reagents having an acid chloride, 2-benzothiazole, or 1-benzotriazol group.
    Organic & biomolecular chemistry, 2008, Dec-21, Volume: 6, Issue:24

    Topics: Antigens; Benzylamines; Chlorides; Cholesterol; Cross-Linking Reagents; Esters; Phthalimides; Proteins; Substrate Specificity; Thiazoles; Triazoles

2008
On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
    Atherosclerosis, 2009, Volume: 205, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Bezafibrate; Cell Line, Tumor; Fenofibrate; Fibroblasts; Gemfibrozil; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pioglitazone; PPAR delta; PPAR gamma; Propionates; Thiazoles; Thiazolidinediones; Triazoles

2009
Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase.
    Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7

    Topics: Activating Transcription Factor 2; Animals; Binding Sites; Diabetes Mellitus, Type 2; Drug Design; HeLa Cells; Humans; Hypoglycemic Agents; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Mice; Phosphorylation; Protein Binding; Structure-Activity Relationship; Substrate Specificity; Thiadiazoles; Thiazoles; Triazoles

2009
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
    Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7

    Topics: Administration, Oral; Animals; Antimalarials; Dihydroorotate Dehydrogenase; Humans; In Vitro Techniques; Malaria; Male; Mice; Microsomes, Liver; Models, Molecular; Oxidoreductases Acting on CH-CH Group Donors; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimidines; Structure-Activity Relationship; Thiazoles; Triazoles

2009
Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:10

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type I; Female; Humans; Indoles; Leukemia; Quinolines; Thiazoles; Topoisomerase I Inhibitors; Triazoles

2009
In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8

    Topics: Amphotericin B; Antifungal Agents; Azoles; Cyclosporine; Drug Interactions; Immunosuppressive Agents; Itraconazole; Microbial Sensitivity Tests; Mucorales; Rhizopus; Sirolimus; Tacrolimus; Thiazoles; Triazoles

2009
2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.
    Bioorganic & medicinal chemistry letters, 2009, Jul-01, Volume: 19, Issue:13

    Topics: Computer Simulation; Crystallography, X-Ray; Drug Design; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Telomere; Thiazoles; Transition Temperature; Triazoles

2009
Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.
    The Journal of biological chemistry, 2009, Jul-17, Volume: 284, Issue:29

    Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Cerulenin; Cluster Analysis; Fatty Acid Desaturases; Fatty Acids, Unsaturated; Fungal Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Hyphae; Male; Mice; Mice, Inbred ICR; Molecular Structure; Mutation; Stearoyl-CoA Desaturase; Survival Rate; Thiazoles; Time Factors; Triazoles; Virulence

2009
QSAR study of PETT derivatives as potent HIV-1 reverse transcriptase inhibitors.
    Journal of molecular graphics & modelling, 2009, Volume: 28, Issue:2

    Topics: Enzyme Inhibitors; HIV Reverse Transcriptase; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Thiazoles; Triazoles

2009
In silico study of naphtha [1, 2-d] thiazol-2-amine with adenosine A 2A receptor and its role in antagonism of haloperidol-induced motor impairments in mice.
    Neuroscience letters, 2009, Oct-09, Volume: 463, Issue:3

    Topics: Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Dopamine; Haloperidol; Humans; Male; Mice; Models, Molecular; Motor Activity; Movement Disorders; Naphthalenes; Receptor, Adenosine A2A; Thiazoles; Triazoles

2009
Trial renews interest in Chagas' disease.
    Lancet (London, England), 2009, Oct-31, Volume: 374, Issue:9700

    Topics: Chagas Disease; Clinical Trials, Phase I as Topic; Drug Industry; Global Health; Humans; Latin America; Prodrugs; Research Support as Topic; Thiazoles; Triazoles

2009
Synthesis and biological activity of pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives: in silico approach.
    Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:5

    Topics: Computational Biology; Drug Design; Enzyme Inhibitors; Expert Systems; Gout Suppressants; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrimidinones; Spectrophotometry, Infrared; Thiazoles; Triazoles; Xanthine Oxidase

2010
New Drugs2010, PART 1.
    Nursing, 2010, Volume: 40, Issue:2

    Topics: Acetamides; Antibodies, Monoclonal; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Azepines; Benzazepines; Benzhydryl Compounds; Benzyl Alcohol; Benzylamines; Cyclams; Cyclopropanes; Drug Combinations; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Ethanolamines; Everolimus; Febuxostat; Fluorenes; Fluoroquinolones; Gout Suppressants; Heterocyclic Compounds; Humans; Immunosuppressive Agents; Indoles; Lacosamide; Milnacipran; Oligopeptides; Phenols; Selective Serotonin Reuptake Inhibitors; Sirolimus; Tapentadol; Thiazoles; Tolvaptan; Triazoles

2010
Linear and nonlinear optical susceptibilities of 3-phenylamino-4-phenyl-1,2,4-triazole-5-thione.
    The journal of physical chemistry. B, 2010, Feb-11, Volume: 114, Issue:5

    Topics: Algorithms; Models, Chemical; Thiazoles; Thiones; Triazoles; X-Ray Diffraction

2010
Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:5

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles

2010
Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.
    Bioorganic & medicinal chemistry, 2010, May-01, Volume: 18, Issue:9

    Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Carboxylic Acids; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Oligopeptides; Thiazoles; Triazoles

2010
Synthesis and dual PPARalpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:7

    Topics: Animals; Chlorocebus aethiops; COS Cells; Humans; PPAR alpha; PPAR delta; Thiazoles; Triazoles

2010
Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:7

    Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Interferon-gamma; Interleukin-10; Myocardium; Polymerase Chain Reaction; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2010
Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes.
    Drug metabolism letters, 2010, Volume: 4, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Oxidoreductases, N-Demethylating; Oximes; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Rifampin; RNA, Messenger; Thiazoles; Transcriptional Activation; Transfection; Triazoles

2010
Drug metabolism and pharmacokinetics of 4-substituted methoxybenzoyl-aryl-thiazoles.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:11

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dogs; Drug Stability; Half-Life; Humans; Male; Metabolic Clearance Rate; Mice; Mice, Inbred ICR; Microsomes, Liver; Predictive Value of Tests; Protein Binding; Rats; Rats, Sprague-Dawley; Small Molecule Libraries; Species Specificity; Thiazoles; Triazoles; Tubulin Modulators

2010
Synthesis, biological evaluation and molecular modeling studies of N-aryl-2-arylthioacetamides as non-nucleoside HIV-1 reverse transcriptase inhibitors.
    Chemical biology & drug design, 2010, Volume: 76, Issue:4

    Topics: Binding Sites; Cell Line; Computer Simulation; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Thiazoles; Thioacetamide; Triazoles

2010
In vitro and in vivo antifungal susceptibilities of the Mucoralean fungus Cunninghamella.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11

    Topics: Amphotericin B; Animals; Antifungal Agents; Caspofungin; Cunninghamella; Diabetes Mellitus, Experimental; Echinocandins; Itraconazole; Lipopeptides; Male; Mice; Microbial Sensitivity Tests; Mucormycosis; Pyrimidines; Thiazoles; Triazoles; Voriconazole

2010
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
    Molecular cancer, 2010, Sep-23, Volume: 9

    Topics: Casein Kinase II; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dasatinib; HeLa Cells; Humans; Immunoblotting; Jurkat Cells; Karyotyping; Liposarcoma, Myxoid; NF-kappa B; Oncogene Proteins, Fusion; Protein Kinase Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Triazoles

2010
Significance of ER-Src axis in hormonal therapy resistance.
    Breast cancer research and treatment, 2011, Volume: 130, Issue:2

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Co-Repressor Proteins; Dasatinib; Drug Resistance, Neoplasm; Drug Synergism; Estrogen Receptor alpha; Female; Gene Knockdown Techniques; Humans; Letrozole; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pyrimidines; Receptor, ErbB-2; RNA Interference; src-Family Kinases; Tamoxifen; Thiazoles; Transcription Factors; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays

2011
Effect of pesticides on plant growth promoting traits of greengram-symbiont, Bradyrhizobium sp. strain MRM6.
    Bulletin of environmental contamination and toxicology, 2011, Volume: 86, Issue:4

    Topics: Alanine; Bradyrhizobium; Dose-Response Relationship, Drug; Fabaceae; Fungicides, Industrial; Glycine; Glyphosate; Herbicides; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Organothiophosphorus Compounds; Oxazines; Symbiosis; Thiamethoxam; Thiazoles; Triazines; Triazoles

2011
mGlu5 and adenosine A2A receptor interactions regulate the conditioned effects of cocaine.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:7

    Topics: Analysis of Variance; Animals; Autoradiography; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Drug Interactions; Excitatory Amino Acid Antagonists; Iodine Isotopes; Locomotion; Male; Mice; Mice, Knockout; Protein Binding; Pyridines; Radionuclide Imaging; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles; Time Factors; Triazines; Triazoles

2012
An approach for rapid development of nasal delivery of analgesics--identification of relevant features, in vitro screening and in vivo verification.
    International journal of pharmaceutics, 2011, Nov-25, Volume: 420, Issue:1

    Topics: Absorption; Administration, Intranasal; Administration, Oral; Analgesics; Animals; Area Under Curve; Benzopyrans; Cell Line; Drug Stability; Ethanolamines; Feasibility Studies; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Male; Meloxicam; Nasal Mucosa; Nebivolol; Permeability; Piroxicam; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Respiratory Mucosa; Thiazines; Thiazoles; Triazoles; Tryptamines

2011
Protective effect of an aminothiazole compound against γ-radiation induced oxidative damage.
    Free radical research, 2011, Volume: 45, Issue:11-12

    Topics: Animals; Apoptosis; DNA Damage; Female; Gamma Rays; Humans; Indoles; Lipid Peroxidation; Lymphocytes; Mice; Mitochondria, Liver; Oxidative Stress; Radiation-Protective Agents; Rats; Rats, Wistar; Spleen; Thiadiazoles; Thiazoles; Triazoles

2011
Toxicological assessment of selective pesticides towards plant growth promoting activities of phosphate solubilizing Pseudomonas aeruginosa.
    Acta microbiologica et immunologica Hungarica, 2011, Volume: 58, Issue:3

    Topics: Brassica; Dose-Response Relationship, Drug; Herbicides; Imidazoles; Neonicotinoids; Nitro Compounds; Oxazines; Pesticides; Phosphates; Pseudomonas aeruginosa; Rhizobium; Rhizosphere; RNA, Bacterial; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Siderophores; Soil Microbiology; Soil Pollutants; Thiamethoxam; Thiazoles; Triazines; Triazoles

2011
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Topics: Acetylcholinesterase; Alzheimer Disease; Azo Compounds; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Indoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Piperidines; Spiro Compounds; Structure-Activity Relationship; Temperature; Thiazoles; Thiosemicarbazones; Triazoles

2012
Diaminothiazoles inhibit angiogenesis efficiently by suppressing Akt phosphorylation.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Cyclin-Dependent Kinases; Human Umbilical Vein Endothelial Cells; Humans; Microtubules; Neovascularization, Pathologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiazoles; Triazoles; Vascular Endothelial Growth Factor A

2012
Design and synthesis of new 4-pyrazolin-3-yl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolin-1-ylthiazoles as potential antimicrobial agents.
    European journal of medicinal chemistry, 2012, Volume: 52

    Topics: Anti-Infective Agents; Chemistry Techniques, Synthetic; Drug Design; Microbial Sensitivity Tests; Thiazoles; Triazoles

2012
Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring.
    European journal of medicinal chemistry, 2012, Volume: 53

    Topics: Animals; Chemistry Techniques, Synthetic; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Hypolipidemic Agents; Male; Oxadiazoles; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Triazoles

2012
Hybrids of ravuconazole: synthesis and biological evaluation.
    European journal of medicinal chemistry, 2012, Volume: 54

    Topics: Anti-Infective Agents; Aspergillus niger; Bacteria; Candida albicans; Chemistry Techniques, Synthetic; Microbial Sensitivity Tests; Thiazoles; Triazoles

2012
Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia.
    Blood, 2012, Aug-30, Volume: 120, Issue:9

    Topics: Acrylamides; Acrylates; Acute Disease; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Drug Evaluation, Preclinical; Exportin 1 Protein; Female; fms-Like Tyrosine Kinase 3; Humans; Kaplan-Meier Estimate; Karyopherins; Leukemia, Myeloid; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Receptors, Cytoplasmic and Nuclear; Thiazoles; Triazoles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays; Young Adult

2012
Increasing human Th17 differentiation through activation of orphan nuclear receptor retinoid acid-related orphan receptor γ (RORγ) by a class of aryl amide compounds.
    Molecular pharmacology, 2012, Volume: 82, Issue:4

    Topics: Amides; Benzamides; Cell Differentiation; Circular Dichroism; Genes, Reporter; Humans; Interleukin-17; Jurkat Cells; Nuclear Receptor Subfamily 1, Group F, Member 3; Primary Cell Culture; Protein Stability; Structure-Activity Relationship; T-Lymphocytes; Th17 Cells; Thiazoles; Triazoles

2012
On the organocatalytic activity of N-heterocyclic carbenes: role of sulfur in thiamine.
    The Journal of organic chemistry, 2012, Jul-20, Volume: 77, Issue:14

    Topics: Aldehydes; Benzoin; Catalysis; Heterocyclic Compounds; Imidazoles; Methane; Molecular Structure; Quantum Theory; Sulfur; Thiamine; Thiazoles; Triazoles

2012
Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis.
    Bioorganic & medicinal chemistry, 2012, Sep-01, Volume: 20, Issue:17

    Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Molecular Structure; Structure-Activity Relationship; Thiazoles; Triazoles

2012
Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents.
    Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Neoplasms; Structure-Activity Relationship; Thiazoles; Triazoles

2012
Rationalization of physico-chemical properties of 5, 6-diarylthiazolo [3,2-b]-1, 2, 4-triazoles towards cyclooxygenase-2 (COX-2) inhibition: a QSAR approach.
    Indian journal of biochemistry & biophysics, 2004, Volume: 41, Issue:4

    Topics: Anti-Inflammatory Agents; Catalytic Domain; Chemistry, Pharmaceutical; Chemistry, Physical; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Design; Electrochemistry; Humans; Inhibitory Concentration 50; Models, Chemical; Models, Theoretical; Quantitative Structure-Activity Relationship; Thiazoles; Triazoles

2004
Cu-catalyzed direct C-H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles.
    Organic & biomolecular chemistry, 2013, Feb-28, Volume: 11, Issue:8

    Topics: Catalysis; Copper; Models, Molecular; Molecular Structure; Organometallic Compounds; Stereoisomerism; Thiazoles; Triazoles

2013
Upregulation of DR5 receptor by the diaminothiazole DAT1 [4-amino-5-benzoyl-2-(4-methoxy phenyl amino) thiazole] triggers an independent extrinsic pathway of apoptosis in colon cancer cells with compromised pro and antiapoptotic proteins.
    Apoptosis : an international journal on programmed cell death, 2013, Volume: 18, Issue:6

    Topics: Apoptosis; bcl-Associated Death Protein; Caspase 8; Colonic Neoplasms; Down-Regulation; HCT116 Cells; Humans; Mitochondria; Receptors, TNF-Related Apoptosis-Inducing Ligand; Serpins; Thiazoles; Triazoles; Up-Regulation; Viral Proteins

2013
Transannulation of 1-sulfonyl-1,2,3-triazoles with heterocumulenes.
    Journal of the American Chemical Society, 2013, Mar-27, Volume: 135, Issue:12

    Topics: Catalysis; Imidazoles; Isocyanates; Isothiocyanates; Methane; Polyenes; Rhodium; Sulfinic Acids; Thiazoles; Triazoles

2013
Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors.
    Bioorganic & medicinal chemistry, 2013, Jun-01, Volume: 21, Issue:11

    Topics: Biological Assay; Glycine max; Herbicides; Molecular Docking Simulation; Plant Proteins; Plant Weeds; Protoporphyrinogen Oxidase; Species Specificity; Structure-Activity Relationship; Sulfonamides; Thiazoles; Triazoles

2013
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:9

    Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2013
Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists.
    Bioorganic & medicinal chemistry, 2013, Oct-01, Volume: 21, Issue:19

    Topics: Adenosine A2 Receptor Antagonists; Animals; Drug Design; HEK293 Cells; Humans; Male; Mice; Models, Biological; Molecular Structure; Protein Binding; Pyrimidines; Receptor, Adenosine A2A; Thiazoles; Triazoles

2013
Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
    The Journal of biological chemistry, 2013, Nov-01, Volume: 288, Issue:44

    Topics: 14-alpha Demethylase Inhibitors; Antiprotozoal Agents; Chagas Disease; Crystallography, X-Ray; Humans; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanosoma cruzi

2013
Dasatinib-letrozole gets split verdict.
    Cancer discovery, 2014, Volume: 4, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Dasatinib; Female; Humans; Letrozole; Nitriles; Protein Kinase Inhibitors; Pyrimidines; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles; Treatment Outcome; Triazoles

2014
Concise and scalable asymmetric synthesis of 5-(1-amino-2,2,2-trifluoroethyl)thiazolo[3,2-b][1,2,4]triazoles.
    Organic & biomolecular chemistry, 2014, Apr-07, Volume: 12, Issue:13

    Topics: Models, Molecular; Molecular Structure; Stereoisomerism; Thiazoles; Triazoles

2014
Host biomarkers of invasive pulmonary aspergillosis to monitor therapeutic response.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:6

    Topics: Amphotericin B; Animals; Annexin A1; Antifungal Agents; Aspergillus fumigatus; Biomarkers; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Invasive Pulmonary Aspergillosis; Neutropenia; Proteomics; Rabbits; Thiazoles; Triazoles

2014
Treat to target in gout by combining two modes of action.
    Rheumatology (Oxford, England), 2014, Volume: 53, Issue:12

    Topics: Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thiazoles; Thioglycolates; Triazoles

2014
A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).
    Journal of medicinal chemistry, 2014, Jun-26, Volume: 57, Issue:12

    Topics: Animals; Binding Sites; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Humans; Kinetics; Mice; Models, Molecular; Protein Conformation; Pyrazoles; Rats; S-Adenosylmethionine; Structure-Activity Relationship; Thiazoles; Triazoles

2014
AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 350, Issue:2

    Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Isoxazoles; Male; Oxadiazoles; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazoles

2014
Molecular structure, vibrational and electronic properties of 4-Phenyl-3H-1,3-thiazol-2-ol using density functional theory and comparison of drug efficacy of keto and enol forms by QSAR analysis.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2014, Nov-11, Volume: 132

    Topics: Electrons; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Quantum Theory; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Stereoisomerism; Thermodynamics; Thiazoles; Triazoles; Vibration

2014
Madurella mycetomatis is highly susceptible to ravuconazole.
    PLoS neglected tropical diseases, 2014, Volume: 8, Issue:6

    Topics: Antifungal Agents; Itraconazole; Ketoconazole; Madurella; Microbial Sensitivity Tests; Thiazoles; Triazoles

2014
Homo- and heteroleptic bismuth(III/V) thiolates from N-heterocyclic thiones: synthesis, structure and anti-microbial activity.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2014, Oct-27, Volume: 20, Issue:44

    Topics: Animals; Anti-Infective Agents; Bismuth; Chlorocebus aethiops; Coordination Complexes; COS Cells; Imidazoles; Microbial Sensitivity Tests; Structure-Activity Relationship; Sulfhydryl Compounds; Thiazoles; Thiones; Triazoles

2014
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
    Neuro-oncology, 2015, Volume: 17, Issue:5

    Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Exportin 1 Protein; Glioblastoma; Humans; Hydrazines; Karyopherins; Macaca fascicularis; Male; Mice; Oxadiazoles; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays

2015
Androgen receptor antagonists and anti-prostate cancer activities of some newly synthesized substituted fused pyrazolo-, triazolo- and thiazolo-pyrimidine derivatives.
    International journal of molecular sciences, 2014, Nov-24, Volume: 15, Issue:11

    Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; CHO Cells; Cricetulus; Humans; Lethal Dose 50; Male; Prostatic Neoplasms; Pyrazoles; Pyrimidines; Thiazoles; Triazoles

2014
Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.
    Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Caspase 9; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A1; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Pyrimidines; Structure-Activity Relationship; Thiazoles; Triazoles

2015
Synthesis and cytotoxicity evaluation of some novel thiazoles, thiadiazoles, and pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones incorporating triazole moiety.
    Molecules (Basel, Switzerland), 2015, Jan-14, Volume: 20, Issue:1

    Topics: Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Spectrophotometry, Infrared; Structure-Activity Relationship; Thiadiazoles; Thiazoles; Triazoles

2015
[In vitro antifungal activity of ravuconazole against isolates of dermatophytes and Candida species from patients with dermatomycoses].
    Medical mycology journal, 2014, Volume: 55, Issue:4

    Topics: Antifungal Agents; Arthrodermataceae; Candida; Dermatomycoses; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Humans; Itraconazole; Naphthalenes; Terbinafine; Thiazoles; Triazoles

2014
Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice.
    Cancer biology & therapy, 2015, Volume: 16, Issue:4

    Topics: Animals; Apoptosis; Azepines; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Everolimus; Homeodomain Proteins; Imidazoles; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Quinolines; Signal Transduction; Thiazoles; Transcription, Genetic; Triazoles; Vincristine

2015
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
    Bioorganic & medicinal chemistry, 2015, May-15, Volume: 23, Issue:10

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Design; Edema; Humans; Inflammation; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Naproxen; Nociception; Pain; Pain Measurement; Structure-Activity Relationship; Thiazoles; Thiones; Triazoles

2015
High Efficiency Antimicrobial Thiazolium and Triazolium Side-Chain Polymethacrylates Obtained by Controlled Alkylation of the Corresponding Azole Derivatives.
    Biomacromolecules, 2015, Jun-08, Volume: 16, Issue:6

    Topics: Alkylation; Anti-Infective Agents; Polymethacrylic Acids; Pseudomonas aeruginosa; Staphylococcus aureus; Thiazoles; Triazoles

2015
Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin.
    Oncotarget, 2015, May-30, Volume: 6, Issue:15

    Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Exportin 1 Protein; G1 Phase Cell Cycle Checkpoints; Humans; Hydrazines; Inhibitor of Apoptosis Proteins; Karyopherins; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mice; Mice, SCID; Neoplasm Proteins; Oxadiazoles; Peritoneal Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Survivin; Thiazoles; Triazoles; Tumor Suppressor Protein p53

2015
New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII.
    Bioorganic & medicinal chemistry letters, 2015, Aug-15, Volume: 25, Issue:16

    Topics: Benzenesulfonamides; Binding Sites; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Enzyme Activation; Humans; Isoenzymes; Models, Biological; Molecular Structure; Sulfonamides; Thiazoles; Triazoles

2015
Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.
    Molecular pharmacology, 2015, Volume: 88, Issue:3

    Topics: Adjuvants, Pharmaceutic; Anastrozole; Anilides; Animals; Antifungal Agents; Antineoplastic Agents; Breast Neoplasms; Cholestanetriol 26-Monooxygenase; Dexmedetomidine; Enzyme Inhibitors; Fadrozole; Female; Hypnotics and Sedatives; Mice; Mice, Inbred C57BL; Nitriles; Protein Binding; Thiazoles; Tosyl Compounds; Triazoles

2015
Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression.
    Oncotarget, 2015, Aug-28, Volume: 6, Issue:25

    Topics: Animals; Apoptosis; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Oncogene Proteins; Ovarian Neoplasms; Oxazoles; RNA, Small Interfering; Thiazoles; Triazoles

2015
Copolymers of acrylonitrile with quaternizable thiazole and triazole side-chain methacrylates as potent antimicrobial and hemocompatible systems.
    Acta biomaterialia, 2015, Volume: 25

    Topics: Acrylonitrile; Anti-Infective Agents; Bacteria; Hemolysis; Humans; Kinetics; Materials Testing; Methacrylates; Microbial Sensitivity Tests; Polymers; Proton Magnetic Resonance Spectroscopy; Thiazoles; Triazoles; Yeasts

2015
Dual-labeled time-resolved fluoroimmunoassay for simultaneous detection of clothianidin and diniconazole in agricultural samples.
    Food chemistry, 2016, Feb-01, Volume: 192

    Topics: Crops, Agricultural; Fluoroimmunoassay; Guanidines; Neonicotinoids; Pesticide Residues; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Triazoles

2016
Design, Synthesis, Characterization and Antimicrobial Evaluation of Some Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolotriazole Class.
    Chemical & pharmaceutical bulletin, 2015, Volume: 63, Issue:9

    Topics: Anti-Bacterial Agents; Antifungal Agents; Candida; Dose-Response Relationship, Drug; Drug Design; Gram-Negative Bacteria; Gram-Positive Bacteria; Heterocyclic Compounds; Microbial Sensitivity Tests; Molecular Structure; Nitrogen; Structure-Activity Relationship; Thiazoles; Triazoles

2015
Therapeutic targeting of BET protein BRD4 delays murine lupus.
    International immunopharmacology, 2015, Volume: 29, Issue:2

    Topics: Animals; Azepines; Disease Progression; DNA; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Mice; Mice, Inbred MRL lpr; Monocytes; Nerve Tissue Proteins; Nuclear Proteins; Proteinuria; Receptors, Cell Surface; Spleen; Tetrazolium Salts; Thiazoles; Transcription Factors; Triazoles

2015
A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds.
    Oncotarget, 2016, Jan-12, Volume: 7, Issue:2

    Topics: Acrylamides; Acrylates; Active Transport, Cell Nucleus; Animals; Antibiotics, Antineoplastic; Biotinylation; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Exportin 1 Protein; Fatty Acids, Unsaturated; HCT116 Cells; Humans; Hydrazines; Karyopherins; Leukocytes, Mononuclear; Mice; Molecular Structure; Receptors, Cytoplasmic and Nuclear; Reproducibility of Results; Thiazoles; Triazoles

2016
7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5.
    Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

    Topics: Benzamides; Binding Sites; Crystallography, X-Ray; Drug Discovery; Indoles; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Protein Domains; Pyrazoles; Pyridines; Pyrimidines; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazines; Triazoles

2016
Impact of HIV-1 Membrane Cholesterol on Cell-Independent Lytic Inactivation and Cellular Infectivity.
    Biochemistry, 2016, Jan-26, Volume: 55, Issue:3

    Topics: beta-Cyclodextrins; Cell Line, Tumor; Cholesterol; HIV Core Protein p24; HIV Envelope Protein gp120; HIV-1; Humans; Membrane Fluidity; Membrane Lipids; Peptides; Sulfhydryl Compounds; Thiazoles; Triazoles

2016
[Development and Distribution of Drugs for NTDs: Efforts of One Pharmaceutical Company].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2016, Volume: 136, Issue:2

    Topics: Animals; Antifungal Agents; Chagas Disease; Cost-Benefit Analysis; Drug Discovery; Drug Industry; Global Health; Humans; Intersectoral Collaboration; Mice; Neglected Diseases; Prodrugs; Thiazoles; Triazoles; Tropical Medicine

2016
Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:8

    Topics: Administration, Oral; Aldehyde Oxidase; Animals; Area Under Curve; Benzamides; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats, Sprague-Dawley; Risk Assessment; Substrate Specificity; Thiazoles; Triazoles

2016
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
    Nature structural & molecular biology, 2016, Volume: 23, Issue:4

    Topics: Azepines; Crystallography, X-Ray; Humans; Ligands; Models, Molecular; Orexin Receptor Antagonists; Orexin Receptors; Protein Binding; Protein Conformation; Pyrrolidines; Thiazoles; Triazoles

2016
IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
    Oncotarget, 2016, Jun-07, Volume: 7, Issue:23

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Baculoviral IAP Repeat-Containing 3 Protein; Bone Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Survival; Cyclohexanes; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; HEK293 Cells; Humans; Inhibitor of Apoptosis Proteins; Mice, Knockout; Osteosarcoma; Phenotype; Pyrroles; Receptor-Interacting Protein Serine-Threonine Kinases; Retinoblastoma Protein; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Transfection; Triazoles; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases

2016
Synthesis of a simplified triazole analogue of pateamine A.
    Organic & biomolecular chemistry, 2016, Jun-14, Volume: 14, Issue:22

    Topics: Antineoplastic Agents; Azides; Catalysis; Chemistry Techniques, Synthetic; Copper; Epoxy Compounds; Macrolides; Thiazoles; Triazoles

2016
Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity.
    ChemMedChem, 2016, 07-19, Volume: 11, Issue:14

    Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillus; Candida; Fluconazole; HEK293 Cells; Hemolysis; Heterocyclic Compounds, 2-Ring; Humans; Itraconazole; Mice; Microbial Sensitivity Tests; Reactive Oxygen Species; Structure-Activity Relationship; Thiazoles; Triazoles; Voriconazole

2016
Leaching of the Neonicotinoids Thiamethoxam and Imidacloprid from Sugar Beet Seed Dressings to Subsurface Tile Drains.
    Journal of agricultural and food chemistry, 2016, Aug-24, Volume: 64, Issue:33

    Topics: Agriculture; Beta vulgaris; Bromides; Chromatography, High Pressure Liquid; Environmental Monitoring; Epoxy Compounds; Groundwater; Herbicides; Imidazoles; Insecticides; Methacrylates; Neonicotinoids; Nitro Compounds; Oxazines; Phenylacetates; Seeds; Soil; Soil Pollutants; Spectrometry, Mass, Electrospray Ionization; Strobilurins; Thiamethoxam; Thiazoles; Triazoles; Water Pollutants, Chemical

2016
Synergistic mortality between a neonicotinoid insecticide and an ergosterol-biosynthesis-inhibiting fungicide in three bee species.
    Pest management science, 2017, Volume: 73, Issue:6

    Topics: Animals; Bees; Brassica rapa; Fungicides, Industrial; Guanidines; Insecticides; Neonicotinoids; Thiazoles; Triazoles

2017
Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.
    Cancer letters, 2016, 12-28, Volume: 383, Issue:2

    Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Everolimus; Exportin 1 Protein; Humans; Hydrazines; Karyopherins; Lymphoma, Non-Hodgkin; Mice, Inbred ICR; Mice, SCID; Oxadiazoles; Prednisone; Protein Kinase Inhibitors; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Time Factors; TOR Serine-Threonine Kinases; Transcription Factor RelA; Triazoles; Tumor Burden; Vincristine; Xenograft Model Antitumor Assays

2016
1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens.
    ACS infectious diseases, 2017, 01-13, Volume: 3, Issue:1

    Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles

2017
Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction.
    European journal of medicinal chemistry, 2017, May-26, Volume: 132

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; Curcumin; Databases, Genetic; Glycogen Synthase Kinase 3; Humans; Liver Neoplasms; Structure-Activity Relationship; Thiazoles; Triazoles; Urea

2017
Design, synthesis, and in vitro evaluation of novel antifungal triazoles.
    Bioorganic & medicinal chemistry letters, 2017, 05-15, Volume: 27, Issue:10

    Topics: Antifungal Agents; Crystallography, X-Ray; Drug Design; Fungi; Microbial Sensitivity Tests; Molecular Conformation; Nitriles; Pyridines; Structure-Activity Relationship; Thiazoles; Triazoles

2017
Uptake and translocation of imidacloprid, thiamethoxam and difenoconazole in rice plants.
    Environmental pollution (Barking, Essex : 1987), 2017, Volume: 226

    Topics: Dioxolanes; Guanidines; Imidazoles; Neonicotinoids; Nitro Compounds; Oryza; Oxazines; Plant Leaves; Plant Roots; Soil; Soil Pollutants; Thiamethoxam; Thiazoles; Triazoles

2017
Design and synthesis of 1,2,3-triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates as tubulin polymerization inhibitors.
    Bioorganic & medicinal chemistry, 2017, 07-01, Volume: 25, Issue:13

    Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Imidazoles; MCF-7 Cells; Molecular Docking Simulation; Molecular Structure; Polymerization; Structure-Activity Relationship; Thiazoles; Triazoles; Tubulin

2017
Micturition dysfunction in four-month old ovariectomized rats: Effects of testosterone replacement.
    Life sciences, 2017, Jun-15, Volume: 179

    Topics: Acetanilides; Androgens; Angiotensin II; Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intramuscular; Letrozole; Muscle, Smooth; Nitriles; Ovariectomy; Postmenopause; Rats; Rats, Sprague-Dawley; Testosterone; Thiazoles; Triazoles; Urethra; Urination Disorders

2017
Lethal effects of Cr(III) alone and in combination with propiconazole and clothianidin in honey bees.
    Chemosphere, 2018, Volume: 191

    Topics: Animals; Bees; Chromium; Drug Interactions; Guanidines; Insecticides; Neonicotinoids; Pesticides; Thiazoles; Triazoles

2018
Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors.
    International journal of molecular sciences, 2018, Jan-11, Volume: 19, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; DNA Gyrase; Molecular Docking Simulation; Protein Binding; Quantitative Structure-Activity Relationship; Schiff Bases; Thiazoles; Topoisomerase II Inhibitors; Triazoles

2018
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:6

    Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Mice; Microbial Sensitivity Tests; Nitroimidazoles; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2018
In vitro antileishmanial activity of ravuconazole, a triazole antifungal drug, as a potential treatment for leishmaniasis.
    The Journal of antimicrobial chemotherapy, 2018, 09-01, Volume: 73, Issue:9

    Topics: Antiprotozoal Agents; Drug Repositioning; Flow Cytometry; Fluorometry; Inhibitory Concentration 50; Leishmania mexicana; Mass Spectrometry; Microscopy, Electron; Microscopy, Fluorescence; Parasitic Sensitivity Tests; Thiazoles; Triazoles

2018
Combined exposure to sublethal concentrations of an insecticide and a fungicide affect feeding, ovary development and longevity in a solitary bee.
    Proceedings. Biological sciences, 2018, 08-22, Volume: 285, Issue:1885

    Topics: Animals; Bees; Dose-Response Relationship, Drug; Feeding Behavior; Female; Fungicides, Industrial; Guanidines; Insecticides; Longevity; Neonicotinoids; Ovary; Thiazoles; Triazoles

2018
Design, Synthesis and Anticancer Activity of New Thiazole-Tetrazole or Triazole Hybrid Glycosides Targeting CDK-2 via Structure-Based Virtual Screening.
    Mini reviews in medicinal chemistry, 2019, Volume: 19, Issue:11

    Topics: Antineoplastic Agents; Azoles; Binding Sites; Catalytic Domain; Cell Line; Cell Survival; Cyclin-Dependent Kinase 2; Drug Design; Glycosides; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Tetrazoles; Thiazoles; Triazoles

2019
The chemokine CXCL1 and its receptor CXCR2 contribute to chronic stress-induced depression in mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:8

    Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Brain-Derived Neurotrophic Factor; Chemokine CXCL1; Depression; Fluoxetine; Glycogen Synthase Kinase 3 beta; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Phenylurea Compounds; Receptors, Interleukin-8B; Stress, Psychological; Thiazoles; Triazoles; Urea

2019
Synthesis and Antibacterial Evaluation of Bis-thiazolium, Bis-imidazolium, and Bis-triazolium Derivatives.
    ChemMedChem, 2019, 07-03, Volume: 14, Issue:13

    Topics: Anti-Bacterial Agents; Cell Line; Cell Survival; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Imidazoles; Microbial Sensitivity Tests; Quaternary Ammonium Compounds; Thiazoles; Triazoles

2019
Porous Microstructured Surfaces with pH-Triggered Antibacterial Properties.
    Macromolecular bioscience, 2019, Volume: 19, Issue:8

    Topics: Anti-Bacterial Agents; Bacterial Adhesion; Hydrogen-Ion Concentration; Microbial Viability; Polystyrenes; Porosity; Staphylococcus aureus; Static Electricity; Structure-Activity Relationship; Surface Properties; Thiazoles; Triazoles

2019
High multi-azole-resistant Malassezia pachydermatis clinical isolates from canine Malassezia dermatitis.
    Medical mycology, 2020, Feb-01, Volume: 58, Issue:2

    Topics: Animals; Antifungal Agents; Azoles; Dermatomycoses; Dog Diseases; Dogs; Drug Resistance, Multiple, Fungal; Itraconazole; Japan; Malassezia; Microbial Sensitivity Tests; Thiazoles; Triazoles

2020
Fungal melanonychia caused by Candida parapsilosis successfully treated with oral fosravuconazole.
    The Journal of dermatology, 2019, Volume: 46, Issue:10

    Topics: Administration, Oral; Aged; Antifungal Agents; Candida parapsilosis; Female; Hand Dermatoses; Humans; Melanosis; Onychomycosis; Prodrugs; Thiazoles; Treatment Outcome; Triazoles

2019
Tinea unguium caused by terbinafine-resistant Trichophyton rubrum successfully treated with fosravuconazole.
    The Journal of dermatology, 2019, Volume: 46, Issue:12

    Topics: Aged; Antifungal Agents; Drug Resistance, Fungal; Female; Hand Dermatoses; Humans; Onychomycosis; Terbinafine; Thiazoles; Tinea; Triazoles

2019
Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors.
    Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19

    Topics: Anti-Bacterial Agents; Biofilms; Molecular Docking Simulation; Molecular Structure; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Triazoles; Virulence Factors

2019
Exploring biological efficacy of coumarin clubbed thiazolo[3,2-b][1,2,4]triazoles as efficient inhibitors of urease: A biochemical and in silico approach.
    International journal of biological macromolecules, 2020, Jan-01, Volume: 142

    Topics: Binding Sites; Catalytic Domain; Coumarins; Enzyme Inhibitors; Models, Molecular; Molecular Structure; Protein Binding; Structure-Activity Relationship; Thiazoles; Triazoles; Urease

2020
Pharmacological Targeting of BET Bromodomains Inhibits Lens Fibrosis via Downregulation of MYC Expression.
    Investigative ophthalmology & visual science, 2019, 11-01, Volume: 60, Issue:14

    Topics: Actins; Adult; Animals; Azepines; Blotting, Western; Cadherins; Cell Movement; Cell Proliferation; Down-Regulation; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibronectins; Fibrosis; Humans; Lens, Crystalline; Proteins; Proto-Oncogene Proteins c-myc; Rabbits; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Thiazoles; Transforming Growth Factor beta2; Triazoles

2019
Antifungal susceptibility of dermatophyte isolates from companion animals to ravuconazole.
    Veterinary dermatology, 2020, Volume: 31, Issue:2

    Topics: Animals; Antifungal Agents; Cats; Drug Resistance, Multiple, Fungal; Microbial Sensitivity Tests; Microsporum; Thiazoles; Tinea; Triazoles

2020
In vitro algaecid effect of itraconazole and ravuconazole on Prototheca species.
    Medical mycology, 2020, Aug-01, Volume: 58, Issue:6

    Topics: Humans; Infections; Itraconazole; Microbial Sensitivity Tests; Prototheca; Thiazoles; Triazoles

2020
In Vitro Ravuconazole Susceptibility of Anthropophilic Dermatophyte Strains Isolated from Japanese Patients.
    Japanese journal of infectious diseases, 2020, May-22, Volume: 73, Issue:3

    Topics: Antifungal Agents; Arthrodermataceae; Dermatomycoses; Drug Resistance, Fungal; Humans; Itraconazole; Microbial Sensitivity Tests; Terbinafine; Thiazoles; Triazoles

2020
Neuraminidase from Influenza A and B Viruses is Susceptible to the Compound 4-(4-Phenyl-1H-1,2,3-Triazol-1-yl)-2,2,6,6-Tetramethylpiperidine-1- Oxyl.
    Current topics in medicinal chemistry, 2020, Volume: 20, Issue:2

    Topics: Antiviral Agents; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Influenza A virus; Influenza B virus; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Neuraminidase; Piperidines; Structure-Activity Relationship; Thiazoles; Triazoles

2020
Antifungal Susceptibility of Clinical Isolates and Artificially Produced Multi-azole-resistant Strains of Cryptococcus neoformans (formerly: Cryptococcus grubii) to Ravuconazole.
    Medical mycology journal, 2020, Volume: 61, Issue:1

    Topics: Antifungal Agents; Cryptococcus neoformans; Drug Resistance, Fungal; Thiazoles; Triazoles

2020
Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection.
    Antimicrobial agents and chemotherapy, 2020, 07-22, Volume: 64, Issue:8

    Topics: Amlodipine; Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2020
    Antimicrobial agents and chemotherapy, 2020, 08-20, Volume: 64, Issue:9

    Topics: Antifungal Agents; Ascomycota; Fungi; Microbial Sensitivity Tests; Nitriles; Pyridines; Thiazoles; Triazoles; Voriconazole

2020
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.
    International journal for parasitology. Drugs and drug resistance, 2020, Volume: 13

    Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2020
1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies.
    Bioorganic & medicinal chemistry letters, 2021, 02-01, Volume: 33

    Topics: Anti-Bacterial Agents; Antifungal Agents; Bacillus subtilis; Biofilms; Candida; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Triazoles

2021
Development of E1224 by leveraging a strategic partnership for the medicines creation against neglected tropical diseases.
    Parasitology international, 2021, Volume: 81

    Topics: Chagas Disease; Global Health; Neglected Diseases; Thiazoles; Triazoles; Tropical Medicine; Trypanocidal Agents; Trypanosoma cruzi

2021
In Vitro activity of ravuconazole against Candida auris and vaginal candida isolates.
    Mycoses, 2021, Volume: 64, Issue:6

    Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Female; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Thiazoles; Triazoles; Vagina

2021
Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole.
    Bioorganic & medicinal chemistry letters, 2021, 05-15, Volume: 40

    Topics: Antifungal Agents; Drug Design; Fungi; Microbial Sensitivity Tests; Pyrimidines; Solubility; Thiazoles; Triazoles

2021
Pharmacological characterization of MT-1207, a novel multitarget antihypertensive agent.
    Acta pharmacologica Sinica, 2021, Volume: 42, Issue:6

    Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Dogs; Electrocardiography; Female; Guinea Pigs; Heart Rate; Hypertension; Male; Molecular Docking Simulation; Rabbits; Rats, Inbred SHR; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha; Stroke; Thiazoles; Triazoles; Vasodilation; Vasodilator Agents

2021
Efficient Dimerization Disruption of
    Journal of medicinal chemistry, 2021, 05-13, Volume: 64, Issue:9

    Topics: Antiprotozoal Agents; Cell Line; Drug Design; Humans; Leishmania infantum; NADH, NADPH Oxidoreductases; Protein Multimerization; Protein Structure, Quaternary; Structure-Activity Relationship; Thiazoles; Triazoles

2021
Development of a stability-indicating assay method by HPLC-DAD and MS characterization of forced degradation products of ravuconazole.
    Journal of chromatographic science, 2022, Feb-16, Volume: 60, Issue:2

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Hydrogen Peroxide; Hydrolysis; Reproducibility of Results; Thiazoles; Triazoles

2022
Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease.
    Experimental parasitology, 2021, Volume: 228

    Topics: Animals; Chagas Disease; Emulsions; Female; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mice; Myocytes, Cardiac; Nanostructures; Rats; Thiazoles; Triazoles; Trypanosoma cruzi

2021
The hidden effects of agrochemicals on plant metabolism and root-associated microorganisms.
    Plant science : an international journal of experimental plant biology, 2021, Volume: 311

    Topics: Agrochemicals; Crops, Agricultural; Herbicides; Italy; Microbiota; Plant Roots; Secondary Metabolism; Solanum lycopersicum; Thiazoles; Triazoles; Xenobiotics

2021
Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors.
    Molecular diversity, 2022, Volume: 26, Issue:4

    Topics: Acetamides; alpha-Glucosidases; Glycoside Hydrolase Inhibitors; Kinetics; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Thiazoles; Triazoles

2022
Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.
    PLoS neglected tropical diseases, 2022, Volume: 16, Issue:2

    Topics: Acetamides; Animals; Antifungal Agents; Ascomycota; Drug Discovery; Drug Evaluation, Preclinical; Fenbendazole; Madurella; Moths; Mycetoma; Neglected Diseases; Piperazines; Pyrimidines; Pyrroles; Thiazoles; Triazoles

2022
Eumycetoma causative agents are inhibited in vitro by luliconazole, lanoconazole and ravuconazole.
    Mycoses, 2022, Volume: 65, Issue:6

    Topics: Antifungal Agents; Humans; Imidazoles; Itraconazole; Madurella; Mycetoma; Thiazoles; Triazoles

2022
Click synthesis of 1,2,3-triazoles using copper iodide nanoparticles anchored poly(sulfonamide-thiazole) modified layered double hydroxides/chitosan nanocomposite.
    International journal of biological macromolecules, 2022, Jun-01, Volume: 209, Issue:Pt A

    Topics: Chitosan; Copper; Hydroxides; Iodides; Nanocomposites; Nanoparticles; Spectroscopy, Fourier Transform Infrared; Sulfanilamide; Thiazoles; Triazoles

2022
Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer.
    British journal of cancer, 2022, Volume: 127, Issue:5

    Topics: Androgen Receptor Antagonists; Androgens; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Naphthalenes; Piperidines; Pyrrolidines; Radiation Tolerance; Receptors, Androgen; Receptors, Estrogen; Tamoxifen; Thiazoles; Triazoles

2022
Design, synthesis and anti-tumor efficacy of novel phenyl thiazole/triazole derivatives as selective TrkA inhibitors.
    Bioorganic & medicinal chemistry, 2022, 10-15, Volume: 72

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Indazoles; Molecular Structure; Morpholinos; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles; Triazoles; Tropomyosin

2022
Discovery of 6-aryl-2-(3,4,5-trimethoxyphenyl)thiazole[3,2-b][1,2,4]triazoles as potent tubulin polymerization inhibitors.
    European journal of medicinal chemistry, 2023, Aug-05, Volume: 256

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Structure; Polymerization; Structure-Activity Relationship; Thiazoles; Triazoles; Tubulin; Tubulin Modulators

2023