triazoles has been researched along with thiazoles in 340 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (6.47) | 18.7374 |
| 1990's | 63 (18.53) | 18.2507 |
| 2000's | 117 (34.41) | 29.6817 |
| 2010's | 111 (32.65) | 24.3611 |
| 2020's | 27 (7.94) | 2.80 |
| Authors | Studies |
|---|---|
| Fotsch, C; St Jean, DJ | 1 |
| Cheng, CC; Daves, GD | 1 |
| Bollag, JM; Henniger, NM | 1 |
| Arrigo-Reina, R; Barbera, F; Castorina, C; Catti, T; Chiechio, S; Mazzone, G; Mazzone, S; Panico, A; Pignatello, R; Russo, A | 1 |
| Turner, NC; Wood, LJ | 1 |
| Cermelli, C; Costantino, L; Malagoli, M; Pecorari, P; Provvisionato, A; Rinaldi, M | 1 |
| Lohmeyer, M; Workman, P | 1 |
| Binnaka, T; Fujimura, K; Inoue, K; Kitagawa, S; Kubota, Y; Mizuno, T; Tani, K; Yamaguchi, T | 1 |
| Lewis, SA; Raeburn, D; Underwood, SL | 1 |
| Aboul Wafa, OM; Berto, FA | 1 |
| Cavero, I; Floch, A; Sedivy, P; Tahraoui, L | 1 |
| Bernat, A; Gigo, V; Herbert, JM; Lale, A; LaPlace, MC; Le Fur, G; Lespy, L; Maffrand, JP; Savi, P; Valette, G | 1 |
| Hara, H; Mase, T; Murase, K; Nagaoka, H; Saito, M; Tomioka, K; Yamada, T | 1 |
| Gilfillan, AM; Hope, WC; Patel, BJ; Welton, AF; Wiggan, GA | 1 |
| Herbert, JM; Lespy, L; Maffrand, JP | 1 |
| Braquet, P; Ferreira, MG; Fonteles, MC | 1 |
| Hirafuji, M; Shinoda, H | 1 |
| Bonne, C; Meynier, F; Muller, A | 1 |
| Horie, M; Mase, T; Nagaoka, H; Sakurai, Y; Tomioka, K; Yamada, T | 1 |
| Bloom, JW; Gomez, J; Halonen, M; Yamamura, HI | 1 |
| Bazill, GW; Dexter, TM | 1 |
| Davenport, JD; Hirsch, KS; Holden, HE; Jones, CD; Krumkalns, EV; Stamm, N; Suhr, RG; Taylor, HM; Winter, MA | 1 |
| Ishimaru, T; Kashi, T; Sakagami, K; Sakai, M | 1 |
| Amico-Roxas, M; Blandino, G; Bonina, F; Caruso, A; Mazzone, G; Panico, AM; Vanella, A | 1 |
| Reeves, JJ; Stables, R | 1 |
| Bozza, PT; Cordeiro, RS; Dias, PM; Faria Neto, HC; Lima, MC; Martins, MA; Silva, PM; Vargaftig, BB | 1 |
| Bernier, JL; Helbecque, N; Henichart, JP; Houssin, R | 1 |
| Barnes, PJ; Birke, FW; Dent, G; Robaut, C; Sybrecht, GW; Ukena, D | 1 |
| Coleman, WG; Williams, LS | 1 |
| Kano, S | 1 |
| Berk, S; Gisser, H | 1 |
| Kochhar, MM; Williams, BB | 1 |
| Andolsek, A; Likar, M; Schauer, P; Stanovnik, B; Tisler, M | 1 |
| Dunoff, RY; Graboyes, H; Jaffe, G; Karash, CB; Pachter, IJ; Snader, K; Weinstock, J | 1 |
| Doorenbos, NJ; Dorn, CP | 1 |
| Almirante, L; Gamba, A; Mugnaini, A; Murmann, W; Olivi, A; Polo, L; Provinciali, E; Rugarli, P | 1 |
| Brittain, RT; Jack, D | 1 |
| Ahgren, C; Backro, K; Bell, FW; Cantrell, AS; Clemens, M; Colacino, JM; Deeter, JB; Engelhardt, JA; Hogberg, M; Jaskunas, SR | 1 |
| Bado, A; Braquet, P; Laigneau, JP; Lewin, MJ; Moizo, L; Sobhani, I; Tarrade, T | 1 |
| Caliş, U; Demirdamar, R; Erol, DD; Ertan, M; Yuluğ, N | 1 |
| Cooper, K; Fray, MJ; Parry, MJ; Richardson, K; Steele, J | 1 |
| Akgün, H; Ertan, M; Rübsemann, K; Tozkoparan, B | 1 |
| Araújo, CV; Barbosa-Filho, JM; Bozza, PT; Castro-Faria-Neto, HC; Cordeiro, RS; Moreira, S; Thomas, G; Tibiriçá, EV | 1 |
| Heard, SO; Perkins, M; Toth, I | 1 |
| Cesur, N; Cesur, Z | 1 |
| Imanishi, N; Koike, H; Morooka, S; Natsume, Y | 1 |
| Dikshit, M; Kumari, R; Seth, P; Srimal, RC | 1 |
| Asakura, K; Narita, S | 1 |
| Bird, IN; Daniels, RH; Elmore, MA; Finnen, MJ; Hill, ME | 1 |
| Farkas, I; Mahmoud, SH; Somsák, L | 1 |
| Bachy, A; Fraisse, L; Herbert, JM; Keane, PE; Lale, A; Laplace, MC; Lassalle, J; Roche, B; Savi, P; Valette, G | 1 |
| Chevallet, P; Demirayak, S; Erol, K; Kiliç, FS; Zitouni, G | 1 |
| Gay, JC | 1 |
| Bourdon, V; Damas, J; Remacle-Volon, G | 1 |
| Giudice, A; Herbert, JM; Le Fur, G; Maffrand, JP; Manara, L; Manzoni, L | 1 |
| Chignard, M; Paulin, D; Renesto, P; Vicart, P | 1 |
| Hata, K; Katsu, K; Kimura, J; Miki, H; Nakamura, T; Toyosawa, T | 1 |
| Hata, K; Katsu, K; Kimura, J; Miki, H; Moriyama, M; Toyosawa, T | 1 |
| Bialer, M; Johannessen, SI; Kupferberg, HJ; Levy, RH; Loiseau, P; Perucca, E | 1 |
| Chen, J; Giris, N | 1 |
| Kakinuma, H; Kaku, Y; Naito, T; Tsukada, I; Tsuruoka, A; Yanagisawa, M | 1 |
| el-Hawash, SA; Habib, NS | 1 |
| Baker, R; Botsford, JL; Navarez, J; Riley, R; Rivera, J; Wright, T | 1 |
| Akiyama, M; Ino, M; Miwa, M; Shimura, M; Sugatani, J; Suzuki, M; Suzuki, Y; Yamazaki, R | 1 |
| Bonner, DP; Fung-Tomc, JC; Huczko, E; Minassian, B | 1 |
| Kakinuma, H; Kaku, Y; Naito, T; Nara, K; Tsukada, I; Tsuruoka, A; Yanagisawa, M | 1 |
| Algueró, M; Bartroli, J; Boncompte, E; Conte, L; Forn, J; García-Rafanell, J; Merlos, M; Ramis, J; Turmo, E; Vericat, ML | 1 |
| Bruyneel, E; Chastre, E; Gespach, C; Kotelevets, L; Mareel, M; Myssiakine, E; Noë, V | 1 |
| Brandt, ME; Doern, GV; Hajjeh, RA; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA | 1 |
| Engelhardt, P; Högberg, M; Kangasmetsä, J; Noréen, R; Sahlberg, C; Vrang, L; Zhang, H | 1 |
| Aoki, FH; Branchini, ML; Mikami, Y; Miyaji, M; Nishimura, K; Taguchi, H; Yamamoto, K; Yang, HC; Yazawa, K | 1 |
| Coleman, DC; Gee, S; Joly, S; Messer, SA; Pfaller, MA; Pujol, C; Soll, DR; Sullivan, DJ | 1 |
| Bertaccini, G; Coppelli, G; Coruzzi, G; Poli, E; Pozzoli, C | 1 |
| Matsushima, T; Nakajima, M; Niki, Y | 1 |
| Fun, HK; Govindasamy, L; Jayanthi, G; Puviarasan, K; Raj, S; Shanmuga, S; Velmurugan, D | 1 |
| Diekema, DJ; Doern, GV; Hollis, RJ; Houston, A; Jones, RN; Messer, SA; Pfaller, MA | 1 |
| Dy, LC; Pei, Y; Travers, JB | 1 |
| Bonner, DP; Fung-Tomc, JC; Huczko, E; Minassian, B; White, TC | 1 |
| Demirdamar, R; Ertan, M; Ertan, R; Kelicen, P; Kilcigil, GA; Tozkoparan, B | 1 |
| Denning, DW; Moore, CB; Walls, CM | 1 |
| Balzarini, J; Bird, LE; Diprose, J; Esnouf, RM; Ikemizu, S; Milton, J; Ren, J; Slater, M; Stammers, DK; Stuart, DI; Warren, J | 1 |
| Siatra-Papastaikoudi, T; Tiligada, E; Tsantili-Kakoulidou, A; Varvaresou, A | 1 |
| Berthou, C; Bourge, JF; Denizot, Y; Geromin, D; Sasportes, M; Sigaux, F; Soulié, A; Zhang, Y | 1 |
| Borgers, M; Borghgraef, P; Dillen, L; Goossens, J; Nobels, G; Sanz, G; Stoppie, P; Szel, H; Van Hove, C; Van Nyen, G; Van Wauwe, J; Vanden Bossche, H; Venet, M; Willemsens, G | 1 |
| Hollis, RJ; Houston, A; Jones, RN; Messer, SA; Pfaller, MA; Yamazumi, T | 1 |
| Mao, C; Sudbeck, EA; Uckun, FM; Venkatachalam, TK | 1 |
| Andriole, VT; Marino, S; Roberts, J; Schock, K | 1 |
| Cooper, S | 1 |
| Carrillo, AJ; Guarro, J | 1 |
| Aktay, G; Ertan, M; Tozkoparan, B; Yesilada, E | 1 |
| Diekema, DJ; Fluit, AC; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA; Sader, HS | 1 |
| Clemons, KV; Stevens, DA | 1 |
| Bobade, AS; Khadse, BG; Paranjape, SD | 1 |
| Coco, BJ; Kirkpatrick, WR; Patterson, TF; Perea, S | 1 |
| Calderon, L; Clemons, KV; Martinez, M; Stevens, DA | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA | 1 |
| Fukayama, N; Hayasaki, Y; Mikamo, H; Satoh, M; Shimamura, Y; Tamaya, T; Uesugi, K; Yin, XH | 1 |
| Boyken, L; Diekema, DJ; Hollis, RJ; Huynh, H; Messer, SA; Pfaller, MA | 1 |
| Diekema, DJ; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA | 2 |
| Arikan, S; Rex, JH | 1 |
| Habel, F; Hoban, D; Laverdiere, M; Restieri, C | 1 |
| Eppinger, E; Meinhardt, G; Schmidmaier, R | 1 |
| Ichihara, S; Murasaki, C; Ohwada, J; Shimma, N; Umeda, I; Yamazaki, T | 1 |
| Lira, R; Payares, G; Romanha, AJ; Sanoja, C; Urbina, JA | 1 |
| Andes, D; Conklin, R; Marchillo, K; Stamstad, T | 1 |
| Kamei, K | 1 |
| Acklin, P; Alberti, D; Buehlmayer, P; Hauffe, S; Lattmann, R; Nick, H; Schupp, J | 1 |
| Avila, NA; Bacher, J; Casler, HE; Groll, AH; Kelaher, AM; Lyman, CA; Petraitiene, R; Petraitis, V; Sarafandi, AA; Sein, T; Walsh, TJ | 1 |
| Barrett, C; Guidato, S; Guthrie, S | 1 |
| Sutton, DA | 1 |
| Gupta, AK; Tomas, E | 1 |
| Arion, VB; Fremuth, M; Jakupec, MA; Keppler, BK; Kukushkin, VY; Pombeiro, AJ; Reisner, E | 1 |
| DAS, NK; PADHI, B; ROUT, MK | 1 |
| BALLONOFF, LB; FEINSTEIN, RN; SEAHOLM, JE | 1 |
| GRAY, AP; HEITMEIER, DE | 1 |
| BUCHSCHACHER, P; FRIED, JH; HANNAH, J; MROZIK, H | 1 |
| Capilla, J; Guarro, J; Ortoneda, M; Pastor, FJ; Rinaldi, MG; Serena, C; Sutton, DA | 1 |
| Barbour, N; Bronson, JJ; Chen, CP; Clark, J; Connolly, TP; Dali, M; Gao, Q; Golik, J; Huang, S; Hudyma, TW; Kang, SH; Knipe, J; Lamb, L; Mathew, M; Matiskella, JD; Medin, I; Mosure, K; Tejwani, R; Ueda, Y; Varia, S; Venkatesh, S; Zheng, M | 1 |
| Abdel Aleem, AH; Abdel-Aal, MT; El Ashry, ES; El-Sayed, WA | 1 |
| El-Bendary, ER; Gineinah, MM; Nasr, MN | 1 |
| Bonner, D; Fung-Tomc, J; Huczko, E; Minassian, B; Washo, T | 1 |
| Cai, C; Katritzky, AR; Singh, SK; Suzuki, K | 1 |
| Capilla, J; Guarro, J; Javier Pastor, F; Ortoneda, M; Pujol, I | 1 |
| SEALE, EE | 1 |
| Foroumadi, A; Moshafi, MH; Rezaee, MA; Soltani, F | 1 |
| Boyken, L; Diekema, DJ; Hollis, RJ; Jones, RN; Messer, SA; Pfaller, MA | 1 |
| Ertan, M; Gökhan, N; Küpeli, E; Tozkoparan, B; Yeşilada, E | 1 |
| Armstrong, D; Avila, NA; Bacher, J; Groll, AH; Hemmings, M; Lyman, CA; Mickiene, D; Peter, J; Petraitiene, R; Petraitis, V; Roussillon, K; Walsh, TJ | 1 |
| Andreotti, E; Manfrini, M; Mares, D; Romagnoli, C; Vicentini, CB | 1 |
| Chiba, K; Kashimoto, S; Sato, Y; Shibamori, K; Tomita, K; Tsuzuki, Y | 1 |
| Dudding, T; Houk, KN | 1 |
| Mao, C; Uckun, FM; Venkatachalam, TK | 1 |
| Chun, MW; Chung, SY; Jeong, LS; Kim, JH; Kim, MJ; Lee, SK; Shin, JH | 1 |
| Auwerx, J; Balzarini, J; Bird, LE; De Clercq, E; Karlsson, A; Oberg, B; Ren, J; Stammers, DK; Stevens, M; Van Rompay, AR | 1 |
| Boyken, L; Diekema, DJ; Hollis, RJ; Messer, SA; Pfaller, MA; Rice, C; Tendolkar, S | 1 |
| Gu, Y; Hu, J; Hu, L; Li, W; Luo, M; Niu, F; Wu, Q; Ye, Y | 1 |
| Cuenca-Estrella, M; Garcia-Effron, G; Gomez-Lopez, A; Mellado, E; Rodriguez-Tudela, JL | 1 |
| Gil-Lamaignere, C; Müller, FM; Zhu, LP | 1 |
| Espinel-Ingroff, A; Jones, RN; Pfaller, MA | 1 |
| Fernández-Torres, B; Guarro, J; Lazéra, Mdos S; Trilles, L; Wanke, B | 1 |
| Kode, A; Menon, VP; Penumathsa, SV; Rajagopalan, R | 1 |
| Perfect, JR | 1 |
| Adolfs, TJ; Borst, AJ; Coolen, HK; de Looff, W; Keizer, HG; Kruse, CG; Lange, JH; McCreary, AC; van Stuivenberg, HH; Veerman, W; Verveer, PC; Wals, HC | 1 |
| Batra, R; Gupta, AK; Kohli, Y | 1 |
| Pan, J; Wang, Q; Zhang, Q; Zheng, RL | 1 |
| Chevallet, P; Kaplancikli, ZA; Kaya, D; Turan-Zitouni, G; Yildiz, MT | 1 |
| Steinbach, WJ | 1 |
| Devi, SK; Rajasekharan, KN; Santhoshkumar, TR; Sengupta, S; Smitha, SL; Sreejalekshmi, KG; Thomas, NE | 1 |
| Chevallet, P; Kaplancikli, ZA; Turan-Zitouni, G | 1 |
| Conetta, B; Gupta, AK; Leonardi, C; Pierce, PF; Stoltz, RR | 1 |
| Fothergill, AW; González, GM; Loebenberg, D; Rinaldi, MG; Sutton, DA | 1 |
| Bacher, J; Groll, AH; Kelaher, A; Mickiene, D; Petraitiene, R; Petraitis, V; Sarafandi, A; Walsh, TJ; Wuerthwein, G | 1 |
| Hough, LB; Lu, Q; Montero, MJ; Nalwalk, JW; Shan, Z; Svokos, K; Wentland, MP | 1 |
| Baker, CJ; Pannaraj, PS; Walsh, TJ | 1 |
| Cuenca-Estrella, M; Garcia-Effron, G; Gomez-Lopez, A; Mellado, E; Monzon, A; Rodriguez-Tudela, JL | 1 |
| Economides, C; Eracleous, E; Kolnagou, A; Kontoghiorghes, GJ | 1 |
| Dandia, A; Khaturia, S; Loupy, A; Mérienne, C; Morgant, G; Singh, R | 1 |
| Hider, RC; Zhou, T | 1 |
| Grasela, DM; Kanamaluru, V; Marino, MR; O'Mara, EM; Smith, RA; Yan, JH | 1 |
| Alves, SH; Azevedo, AC; Boff, E; Da Matta, DA; Guarro, J; Loreto, ES; Santurio, JM | 1 |
| Aperis, G; Mylonakis, E | 1 |
| Kontoghiorghes, GJ | 1 |
| Bacher, J; Kelaher, AM; Lin, P; Meletiadis, J; Petraitiene, R; Petraitis, V; Schaufele, RL; Sein, T; Stergiopoulou, T; Walsh, TJ | 1 |
| Cano, J; Gené, J; Gilgado, F; Guarro, J; Serena, C | 1 |
| Denning, DW; Gardiner, RE; Howard, SJ; Moore, CB; Park, S; Perlin, DS; Webster, I | 1 |
| D'Cruz, OJ; Uckun, FM | 1 |
| Agrawal, RK; Ravichandran, V | 1 |
| Azuma, T; Fukuda, J; Hata, M; Hikichi, H; Ito, S; Kaneko, N; Kawagoe-Takaki, H; Kawamoto, H; Kimura, T; Maehara, S; Ohta, H; Sakai, N; Satow, A; Suzuki, G | 1 |
| Scheinfeld, N | 1 |
| Adams, CL; Cowen, MS; Lawrence, AJ; Short, JL | 1 |
| Han, X; Wang, DX | 1 |
| Abdel-Hamid, H; Aouad, MR; Ashry, ES; Kassem, AA; Khattab, ShA; Louis, FF | 1 |
| Fisher, PW; Hofmann, GA; Janson, CA; Johnson, RK; Kirkpatrick, RB; Ma, C; Marino, JP; Mattern, M; Meek, TD; Ryan, MD; Schulz, C; Smith, WW; Tew, DG; Thompson, SK; Tomazek, TA; Veber, DF; Xiong, WC; Yamamoto, Y; Yamashita, K; Yang, G | 1 |
| Chhibber, M; Gupta, S; Sinha, S; Surolia, A | 1 |
| Papakostas, GI; Shelton, RC | 1 |
| Eckert, A; Mensah-Nyagan, AG; Patte-Mensah, C; Schaeffer, V | 1 |
| Bartberger, MD; Castro, VM; Chen, M; Emery, M; Fotsch, C; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Johansson, L; Jordan, SR; Komorowski, R; Li, A; Matsumoto, G; McRae, K; Moniz, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J | 1 |
| Adhikari, S; De, S; Devasagayam, TP; Menon, VP; Tilak-Jain, J | 1 |
| Alastruey-Izquierdo, A; Alcazar-Fuoli, L; Cuenca-Estrella, M; Mellado, E; Monzon, A; Rodriguez-Tudela, JL | 1 |
| Knipe, JO; Mosure, KW | 1 |
| Chen, S; Lui, K; Mori, T; Tamura, T; Zhou, D | 1 |
| Kruse, CG; Lange, JH | 1 |
| Karthikeyan, MS | 1 |
| Ayala, J; Elizondo, M; González, GM | 1 |
| Kalgutkar, AS; Obach, RS; Soglia, JR; Zhao, SX | 1 |
| Lewis, JW; Tipton, DA | 1 |
| Kazan, F; Ozkirimli, S; Tunali, Y | 1 |
| Bertilsson, L; Hynninen, VV; Korhonen, T; Kurkinen, KJ; Laine, K; Neuvonen, PJ; Olkkola, KT | 1 |
| Abe, H; Morita, H; Sakai, M; Sheikh, MC; Takagi, S | 1 |
| Akita, N; Fukutomi, T; Gonzalez, FJ; Hossain, MA; Kimura, G; Ogata, M; Staels, B; Suzuki, S; Tsujita, M; Yokoyama, S | 1 |
| Barile, E; Chen, LH; Chen, V; Dahl, R; De, SK; Emdadi, A; Machleidt, T; Murphy, R; Pellecchia, M; Riel-Mehan, M; Stebbins, JL; Yuan, H | 1 |
| Baldwin, J; Buckner, FS; Charman, S; Charman, WN; Creason, S; El Mazouni, F; Gujjar, R; Marwaha, A; Phillips, MA; Rathod, PK; Shackleford, DM; White, J; White, KL | 1 |
| Bailly, C; Baldeyrou, B; Beauchard, A; Besson, T; Chérouvrier, JR; Domon, L; Jaunet, A; Lansiaux, A; Murillo, L; Picot, L; Thiéry, V | 1 |
| Dannaoui, E; Lortholary, O; Schwarz, P | 1 |
| Bernier, JL; Brassart, B; Chavatte, P; El Bakali, J; Farce, A; Fontaine, G; Guédin, A; Hénichart, JP; Houssin, R; Klupsch, F; Mergny, JL; Riou, JF; Roussel, P | 1 |
| Becker, J; Davison, J; Hu, W; Jiang, B; Kauffman, S; Martel, N; Martin, CE; Ocampo, P; Oh, C; Roemer, T; Sillaots, S; Trosok, S; Veillette, K; Wang, H; Xu, D; Yang, M; Zhang, L | 1 |
| Fassihi, A; Moeinifard, B; Sabet, R | 1 |
| Barodia, SK; Kumar, JB; Kumari, R; Luthra, PM; Mishra, CB; Prakash, A | 1 |
| Moloney, A | 1 |
| Bodade, RG; Dawane, BS; Khandare, NT; Khobragade, CN; Konda, SG | 1 |
| Hussar, DA | 2 |
| Auluck, S; Kityk, IV; Reshak, AH; Stys, D | 1 |
| Goldani, LZ; Pasqualotto, AC; Thiele, KO | 1 |
| Chandrashekar, SM; Kistayya, C; Mallikarjuna, BP; Rajendraprasad, Y; Suresh Kumar, GV | 1 |
| Vera-Cabrera, L; Welsh, E; Welsh, O | 1 |
| Abdel-Rahman, H; Hamada, T; Hamada, Y; Hidaka, K; Igawa, N; Ikari, H; Kimura, T; Kiso, Y; Nagamine, A; Nguyen, JT; Sohma, Y; Tagad, HD; Yamani, A | 1 |
| Aasen, AJ; Ciocoiu, CC; Hansen, TV; Nguyen, HH; Nikolić, N; Thoresen, GH | 1 |
| Bahia, MT; Caldas, IS; Carneiro, CM; Crepalde, G; de Lana, M; Diniz, Lde F; Guedes, PM; Talvani, A; Urbina, JA | 1 |
| Jeong, H; Koh, KH; Yang, K | 1 |
| Dalton, JT; Li, CM; Lu, Y; Miller, DD; Narayanan, R | 1 |
| Hong, Y; Rugang, Z; Xiaohe, Z; Xiuqing, S; Yu, Q | 1 |
| Guarro, J; Mayayo, E; Pastor, FJ; Pujol, I; Ruíz-Cendoya, M; Sutton, DA | 1 |
| Bovée, JV; Bruijn, IH; Hogendoorn, PC; Schrage, YM; Szuhai, K; Willems, SM | 1 |
| Chakravarty, D; Challa, R; Cortez, V; Nair, BC; Tekmal, RR; Vadlamudi, RK; Vallabhaneni, S | 1 |
| Sheng, CQ; Wang, SZ; Zhang, WN | 1 |
| Ahemad, M; Khan, MS | 2 |
| Türel, O | 1 |
| Brown, RM; Duncan, JR; Lawrence, AJ; Ledent, C; Stagnitti, MR | 1 |
| Chow, MS; Wang, S; Zuo, Z | 1 |
| De, S; Devasagayam, TP | 1 |
| Almansour, AI; Arumugam, N; Ashraf Ali, M; Choon, TS; Elumalai, K; Ismail, R; Kumar, RS; Osman, H; Singh, A | 1 |
| Ashokan, B; Bharathan, A; Komalam, RJ; Rajasekharan, KN; Santhoshkumar, TR; Sengupta, S; Sreerekha, KV; Thamkachy, R; Thomas, SA | 1 |
| Abdel-Latif, E; Abdel-Wahab, BF; Awad, GE; Mohamed, HA | 1 |
| Belavagi, NS; Gong, YD; Kalashetti, MB; Khan, AY; Khazi, IA; Mohammed Iqbal, AK | 1 |
| Bobade, VD; Gaikwad, ND; Patil, SV | 1 |
| Blum, W; Caligiuri, M; Croce, CM; Garzon, R; Kauffman, M; Klisovic, R; Marcucci, G; Na, C; Ranganathan, P; Santhanam, R; Shacham, S; Walker, A; Yu, X | 1 |
| An, G; Fang, L; Leung, S; Li, Y; Wang, S; Wang, Y; Wisely, B; Xiang, Z; Zhang, G; Zhang, J; Zhang, W; Zhong, Z; Zhou, L | 1 |
| Hollóczki, O; Kelemen, Z; Nyulászi, L | 1 |
| Donald, MB; Kurth, MJ; Phuan, PW; Rodriguez, KX; Shay, H; Verkman, AS | 1 |
| Dadmal, TL; Janaki Ramaiah, M; Kosurkar, UB; Kumbhare, RM; Pal-Bhadra, M; Pushpavalli, SN | 1 |
| Chaturvedi, SC; Manivannan, E; Prasanna, S | 1 |
| Guan, Y; Hu, H; Jiang, J; Lin, C; Pan, Y; Wang, L; Xie, Z; Zhu, D; Zhu, X | 1 |
| Lekshmi, SU; Rajasekharan, KN; Santhoshkumar, TR; Sengupta, S; Thamkachy, R; Thomas, SA; Vasudevan, S | 1 |
| Chuprakov, S; Fokin, VV; Kwok, SW | 1 |
| Hao, GF; Luo, YP; Tan, Y; Wu, QY; Xi, Z; Yang, GF; Yang, SG; Zuo, Y | 1 |
| Czajkowska, B; Krzystanek, M; Lapray, D; Markowski, G; Pałasz, A; Peyron, C; Rojczyk-Gołębiewska, E; Skowronek, R; Wiaderkiewicz, R | 1 |
| Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR | 1 |
| Sebestyén, Z; Szabó, B; Szepesi, K | 1 |
| Kumar, N; Kumari, N; Luthra, PM; Mishra, CB; Prakash, A; Sharma, D | 1 |
| Alexander, PW; Chaplin, JH; Charman, SA; Chatelain, E; Hargrove, TY; Keenan, M; Lepesheva, GI; Perez, CJ; Waterman, MR; Wawrzak, Z | 1 |
| Hoyer, D; Jacobson, LH | 1 |
| Maehara, S | 1 |
| Chew, GT; Sahebkar, A; Watts, GF | 1 |
| Baumgartner, S; Fleischmann, R; Hingorani, V; Kerr, B; Manhard, K; Miner, JN; Polvent, E; Quart, B; Shen, Z; Suster, M; Yeh, LT | 1 |
| Han, J; Mei, H; Pan, Y; Soloshonok, VA; Xie, C; Xiong, Y | 1 |
| Jain, MR; Krel, M; Li, H; Perlin, DS; Petraitiene, R; Petraitis, V; Walsh, TJ; Zhao, Y | 1 |
| Edwards, NL; So, A | 1 |
| Jansen, TL | 1 |
| Ambrus, G; Cole, DC; Davenport, R; Ellery, J; Fosbeary, R; Hixon, MS; Jennings, AJ; Kadotani, A; Kamada, Y; Kamran, R; Lanier, M; Matsumoto, S; Mizukami, A; Okada, K; Okubo, S; Saikatendu, K; Walsh, L; Wu, H | 1 |
| Raboisson, P; Swedberg, MD | 1 |
| Belaidi, S; Chand, S; Pathak, SK; Prasad, O; Sachan, AK; Sinha, L; Srivastava, R | 1 |
| Ahmed, SA; de Hoog, GS; Duncanson, F; Fahal, AH; Kloezen, W; van de Sande, WW; Zijlstra, EE | 1 |
| Andrews, PC; Blair, VL; Brammananth, R; Coppel, RL; Crellin, PK; Luqman, A | 1 |
| Green, AL; Hsu, JH; Hubbell-Engler, B; Jones, K; Knoff, DS; Kung, AL; Ligon, KL; Maire, CL; McCauley, D; Perry, JA; Ramkissoon, LA; Ramkissoon, SH; Shacham, S | 1 |
| Al-Harbi, NO; Amr, Ael-G; Bahashwan, SA; Fayed, AA; Ramadan, MA | 1 |
| Han, X; Shen, Y; Shi, Y; Wang, J; Wang, S; Yao, J; Zhang, N | 1 |
| Appalanaidu, K; Bhadra, MP; Dadmal, TL; Kishore, KS; Kumbhare, RM; Pushpa Valli, SN; Ramaiah, MJ; Rao, YK; Tiwari, SK | 1 |
| Abdelhamid, AO; Ahmed, SA; Gomha, SM | 1 |
| Ikeda, F; Iyoda, T; Mikawa, T; Suzuki, M; Yamaguchi, H | 1 |
| Ito, TK; Kadariya, Y; Pei, J; Sementino, E; Tan, Y; Testa, JR | 1 |
| Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A | 1 |
| Fernández-García, M; Gómez-Garcés, JL; López, D; López-Fabal, F; Tejero, R | 1 |
| Cominetti, D; De Cesare, M; Deraco, M; Doldi, V; Friedlander, S; Gandellini, P; Kauffman, MG; Landesman, Y; Lopergolo, A; Pennati, M; Shacham, S; Zaffaroni, N | 1 |
| Alcaro, S; Bianco, G; Ceruso, M; Cottiglia, F; Distinto, S; Maccioni, E; Meleddu, R; Melis, C; Supuran, CT | 1 |
| Lin, JB; Mast, N; Pikuleva, IA | 1 |
| Chen, H; Ding, HF; Dong, Z; Fang, D; Huang, S; Jing, Q; Lu, Y; Su, SB; Yang, L | 1 |
| Fernández-García, M; Gómez-Garcés, JL; Gutiérrez, B; López, D; López-Fabal, F; Tejero, R | 1 |
| Feng, L; Hua, X; Sheng, E; Shi, H; Wang, M; Yu, T; Zhou, L | 1 |
| Bancescu, G; Barbuceanu, F; Barbuceanu, SF; Draghici, C; Saramet, G | 1 |
| Sha, H; Sun, Y; Wei, S | 1 |
| Baloglu, E; Crochiere, ML; Del Alamo, D; Donovan, S; Kauffman, M; Klebanov, B; Landesman, Y; Lee, M; Shacham, S | 1 |
| Sabio, M; Topiol, S | 1 |
| Abrams, C; Aneja, R; Bailey, L; Bastian, AR; Chaiken, I; Huynh, J; Kalyana Sundaram, RV; Li, H; Papazoglou, E; Rashad, AA; Weiss, K; Wrenn, S | 1 |
| Khouzam, HR | 1 |
| Asada, M | 1 |
| Byers, FW; Crouch, RD; Daniels, JS; Emmitte, KA; Lindsley, CW; Morrison, RD | 1 |
| Babaoglu, K; Brautigam, CA; Clark, L; Coleman, PJ; Gotter, AL; Harrell, CM; Renger, JJ; Roecker, AJ; Rosenbaum, DM; Scheuermann, TH; Shao, Z; Winrow, CJ; Yin, J | 1 |
| Gupte, A; Hawkins, CJ; Miles, MA; Shekhar, TM; Tascone, B; Taylor, S; Walkley, CR | 1 |
| Brown, SL; Cuyamendous, C; Field, JJ; Harvey, JE; Hemi Cumming, A; Miller, JH; Tao, X; Teesdale-Spittle, PH | 1 |
| Garneau-Tsodikova, S; Ngo, HX; Shrestha, SK | 1 |
| Balmer, ME; Bucheli, TD; Garcia Delgado, MF; Hanke, I; Huntscha, S; Kasteel, R; Poiger, T; Wettstein, FE | 1 |
| Bogo, G; Bortolotti, L; Bosch, J; Medrzycki, P; Molowny-Horas, R; Porrini, C; Renzi, MT; Sgolastra, F; Teper, D; Tosi, S | 1 |
| Aboukameel, A; Azmi, AS; Baloglu, E; Bhutani, D; Carlson, R; Elloul, S; Kauffman, M; Mohammad, RM; Muqbil, I; Senapedis, W; Shacham, S; Zonder, J | 1 |
| Asafo-Adjei, EA; Corey, BW; Ernst, RK; Hittle, LE; Huggins, WM; Jacobs, AC; Melander, C; Melander, RJ; Thompson, MG; Zurawski, DV | 1 |
| Yamaguchi, H | 1 |
| Huang, CF; Liu, HS; Ramesh, C; Su, CL; Tseng, CL; Yao, CF | 1 |
| Cai, Z; Ding, Z; Jiang, Y; Jin, Y; Li, R; Ni, T; Pang, L; Wang, T; Xie, F; Yu, S; Zhang, D; Zhao, J | 1 |
| Chai, Y; Cheng, J; Cui, K; Ge, J; Li, Y; Liu, X; Yan, H; Yu, X | 1 |
| Bagul, C; Bhattacharjee, D; Jain, N; Kamal, A; Kapure, JS; Shaik, SP; Subba Rao, AV; Sultana, F; Vishnuvardhan, MVPS | 1 |
| Antunes, E; Bonilla-Becerra, SM; Calmasini, FB; de Oliveira, MG; Rojas-Moscoso, JA; Zanesco, A | 1 |
| Blasioli, S; Braschi, I; Medrzycki, P; Molowny-Horas, R; Porrini, C; Renzi, T; Sgolastra, F; Tosi, S | 1 |
| Benedec, D; Ionuţ, I; Nastasă, C; Oniga, O; Stana, A; Tamaian, R; Tiperciuc, B; Vodnar, DC | 1 |
| Almeida, IC; Alonso-Vega, C; Alves, F; Gascon, J; Ortiz, L; Pinazo, MJ; Ribeiro, I; Schijman, A; Strub-Wourgaft, N; Torrico, F | 1 |
| Bahia, MT; Caldas, IS; Diniz, LF; Mazzeti, AL; Ribeiro, I | 1 |
| Ishii, Y; Ito, Y; Matsuki, S; Ogawa, O; Sanpei, K; Schuck, EL; Takeda, K; Uemura, N | 1 |
| Cola Fernandes Rodrigues, J; de Souza, W; Lima Prado Godinho, J; Teixeira de Macedo Silva, S; Urbina, JA; Visbal, G | 1 |
| Arnan, X; Bosch, J; Cabbri, R; Isani, G; Medrzycki, P; Sgolastra, F; Teper, D | 1 |
| Okubo, A; Tsubouchi, I; Watanabe, S | 1 |
| Alonso-Vega, C; Alves, F; de la Barra, A; Flevaud, L; Garcia, L; Gascon, J; Illanes, D; Juiz, N; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Schijman, AG; Torrico, F | 1 |
| Abbas, EMH; Awad, HM; El-Kady, DS; El-Sayed, WA; Kassem, AF | 1 |
| Chai, HH; Chen, GZ; Chen, WX; Chen, YS; Fu, XC; Guo, YW; Li, SP; Ma, L; Song, MY; Sun, HT; Tan, MX | 1 |
| Boisbrun, M; Duval, RE; Fontanay, S; Thomas, B; Varbanov, M | 1 |
| Cuervo-Rodríguez, R; Del Campo, A; Echeverría, C; Fernández-García, M; Muñoz-Bonilla, A; San Martín, M | 1 |
| Aramaki, C; Kamata, H; Kano, R; Mori, Y; Murayama, N; Yamagishi, K; Yokoi, S | 1 |
| Fukushima, S; Hiruma, M; Ihn, H; Kano, R; Kimura, U; Matsumoto, T; Noguchi, H; Yaguchi, T | 2 |
| Akbar, S; Ganapathi, T; Ganesh Kumar, C; Kamal, A; Khan, I; Nagendra Babu, B; Sayeed, IB; Shareef, MA; Sirisha, K | 1 |
| Ahsan Halim, S; Al-Harrasi, A; Csuk, R; Ibrar, A; Khan, A; Khan, I; Mehsud, S; Saeed, A | 1 |
| Chen, B; Chen, J; Huang, M; Huang, S; Liu, Y; Sun, Y; Wang, B; Wang, C; Wang, X; Xiong, L; Zhao, N | 1 |
| Huruta, H; Kamata, H; Kano, R | 1 |
| Ito, T; Kamata, H; Kano, R; Miura, A; Suzuki, K | 1 |
| Harada, K; Hase, M; Hiruma, J; Hiruma, M; Kamata, H; Kano, R; Noguchi, H; Yokota, M | 1 |
| Abrantes, JL; Alves, CM; Cunha, AC; de Freitas, CS; de Melo, GR; Ferreira, VF; Fintelman-Rodrigues, N; Jordão, AK; Marttorelli, A; Sacramento, CQ; Souza, TML | 1 |
| Kamata, H; Kano, R; Sugita, T | 1 |
| Bahia, MT; Caldas, IS; Diniz, LF; Machado, YA; Marques, MJ; Martins-Filho, OA; Mazzeti, AL; Novaes, RD; Santos, LJS; Vilas Boas, BR | 1 |
| Dong, J; Li, D; Li, X; Liu, W; Mei, H; Song, N; Zheng, H | 1 |
| Au, HYA; Bhattacharyya, T; Chatelain, E; Franco, CH; Freitas-Junior, LH; Giardini, MA; Le, H; Madeira, RP; Miles, MA; Moraes, CB; Pascoalino, BS; Romera, LMD; Schenkman, S; Torrecilhas, AC; Warhurst, DC | 1 |
| Banothu, J; Bavantula, R; Ganesh Kumar, C; Gondru, R; Kanugala, S; Pasupuleti, M; Raj, S | 1 |
| Hata, K | 1 |
| Dong, J; Kan, S; Liang, G; Liu, W; Song, N; Zhang, M; Zheng, H | 1 |
| Blokhina, SV; Doroshenko, IA; Levshin, IB; Ol'khovich, MV; Perlovich, GL; Sharapova, AV | 1 |
| Huang, YH; Liu, JG; Miao, CY; Qing, SL; Su, DF; Tian, JS; Wang, P; Wang, SN; Xu, JY; Xu, TY | 1 |
| Camarasa, MJ; de Lucio, H; Gago, F; García-Soriano, JC; Jiménez-Ruiz, A; Revuelto, A; Sánchez-Murcia, PA; Velázquez, S | 1 |
| Brêtas, CM; César, IC; Gazzinelli, BP | 1 |
| Bahia, MT; de Castro, KCMP; Mazzeti, AL; Mendes, PF; Mosqueira, VCF; Spósito, PÁ; Urbina, JA | 1 |
| Borruso, L; Cesco, S; Lucini, L; Mimmo, T; Miras-Moreno, B; Pii, Y; Puglisi, E; Spini, G; Taskin, E; Tiziani, R; Trevisan, M; Zangrillo, MS | 1 |
| Alamir, A; Asgari, MS; Bandarian, F; Faramarzi, MA; Hajimiri, MH; Hamedifar, H; Hosseini, S; Iraji, A; Larijani, B; Mahdavi, M; Mojtabavi, S; Moradi, S; Nasli Esfahani, A; Nasli-Esfahani, E | 1 |
| Chin, CM; Scarim, CB | 1 |
| Bonifaz, A; Burrows, J; Eadie, K; Fahal, A; Konings, M; Lim, W; Nyuykonge, B; Perry, B; Samby, K; Smeets, J; Todd, M; van de Sande, W; Verbon, A | 1 |
| Abastabar, M; Badali, H; Bonifaz, A; Fahal, A; Lim, W; Nyuykonge, B; van Amelsvoort, L; van de Sande, W; Verbon, A | 1 |
| Alavinia, S; Babamoradi, J; Ghorbani-Vaghei, R | 1 |
| Eisner, JR; Lerner, LM; Michmerhuizen, AR; Pesch, AM; Pierce, LJ; Rae, JM; Schwartz, R; Speers, CW; Ward, C; Wilder-Romans, K; Zhang, A | 1 |
| Jiang, N; Liu, S; Tan, Z; Wang, F; Wang, X; Yang, J; Zhai, X; Zhang, J | 1 |
| Guan, Q; Hong, Y; Li, B; Li, M; Li, N; Li, X; Wu, L; Zhang, B; Zhang, W | 1 |
34 review(s) available for triazoles and thiazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
The chemistry and biochemistry of C-nucleosides.
Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Formycins; Imidazoles; Isoxazoles; Nucleosides; Oxadiazoles; Pseudouridine; Purine Nucleosides; Pyrazoles; Showdomycin; Thiazoles; Triazoles; Uridine | 1976 |
Histamine H2-antagonists--past, present and future.
Topics: Animals; Aspirin; Burimamide; Chemical Phenomena; Chemistry; Cimetidine; Dogs; Furans; Gastric Acid; Guanidines; Guinea Pigs; Half-Life; Histamine H2 Antagonists; Humans; Imidazoles; Methylamines; Ranitidine; Rats; Stomach; Thiazoles; Triazoles | 1983 |
[Present problems and future trend of antifungals for deep seated mycosis. Azole antifungal agents].
Topics: Animals; Antifungal Agents; Azoles; Dosage Forms; Drug Interactions; Drug Resistance, Microbial; Fungi; Humans; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 1999 |
Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase.
Topics: Amino Acid Substitution; Drug Design; Drug Resistance, Microbial; HIV; HIV Reverse Transcriptase; Humans; Models, Molecular; Mutation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Triazoles | 2000 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
Ravuconazole Eisai/Bristol-Myers Squibb.
Topics: Administration, Oral; Animals; Antifungal Agents; Clinical Trials as Topic; Humans; Mycoses; Structure-Activity Relationship; Thiazoles; Triazoles | 2002 |
[Present status and future prospects of azole antifungal agents in Japan].
Topics: Antifungal Agents; Azoles; Cyclodextrins; Drug Design; Fluconazole; Forecasting; Itraconazole; Japan; Miconazole; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2002 |
Development of tridentate iron chelators: from desferrithiocin to ICL670.
Topics: Animals; Benzoates; Callithrix; Chemical Phenomena; Chemistry, Physical; Deferasirox; Dihydropyridines; Dogs; Humans; Iron; Iron Chelating Agents; Rats; Thiazoles; Triazoles | 2003 |
Laboratory evaluation of new antifungal agents against rare and refractory mycoses.
Topics: Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Echinocandins; Fungi; Humans; Lipopeptides; Microbial Sensitivity Tests; Mitosporic Fungi; Mycoses; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2002 |
New antifungal agents.
Topics: Administration, Oral; Anidulafungin; Anti-Bacterial Agents; Antifungal Agents; Caspofungin; Chemistry, Pharmaceutical; Drug Approval; Echinocandins; Humans; Lipopeptides; Macrolides; Mycoses; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2003 |
Antifungal resistance: the clinical front.
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Caspofungin; Drug Resistance, Fungal; Echinocandins; Fluconazole; Health Status; Humans; Lipopeptides; Peptides, Cyclic; Pyrimidines; Risk Factors; Thiazoles; Treatment Outcome; Triazoles; United States; Voriconazole | 2004 |
Antifungal agents in children.
Topics: Age Factors; Amphotericin B; Anidulafungin; Antifungal Agents; Caspofungin; Chemistry, Pharmaceutical; Child; Clinical Trials as Topic; Drug Approval; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Lipopeptides; Lipoproteins; Micafungin; Mycoses; Patient Selection; Pediatrics; Peptides, Cyclic; Pyrimidines; Safety; Thiazoles; Triazoles; United States; Voriconazole | 2005 |
Advances in iron overload therapies. prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NA11 and their combinations.
Topics: Benzoates; Carboxylic Acids; Deferasirox; Deferiprone; Deferoxamine; Drug Therapy, Combination; Hemochromatosis; Humans; Iron Chelating Agents; Iron Overload; Pyridones; Siderophores; Thalassemia; Thiazoles; Triazoles | 2005 |
Newer triazole antifungal agents: pharmacology, spectrum, clinical efficacy and limitations.
Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Cryptococcosis; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Resistance, Fungal; Drug Therapy, Combination; Humans; Pyrimidines; Randomized Controlled Trials as Topic; Thiazoles; Triazoles; Voriconazole | 2006 |
Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers.
Topics: Benzoates; Carboxylic Acids; Chelation Therapy; Clinical Trials as Topic; Deferasirox; Deferiprone; Deferoxamine; Drug Evaluation; Drug Therapy, Combination; Forecasting; Hemochromatosis; Humans; Hydroxyethyl Starch Derivatives; Iron Chelating Agents; Iron Overload; Molecular Structure; Pyridones; Starch; Thalassemia; Thiazoles; Transfusion Reaction; Triazoles | 2006 |
Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Topics: Acquired Immunodeficiency Syndrome; Anti-Retroviral Agents; Chemistry, Pharmaceutical; Drug Design; Drug Industry; HIV; HIV Reverse Transcriptase; Humans; Models, Chemical; Models, Molecular; Mutation; Pyrimidines; Reverse Transcriptase Inhibitors; Thiazoles; Thymine; Triazoles | 2006 |
A review of deferasirox, bortezomib, dasatinib, and cyclosporine eye drops: possible uses and known side effects in cutaneous medicine.
Topics: Animals; Antineoplastic Agents; Benzoates; Boronic Acids; Bortezomib; Cyclosporine; Dasatinib; Deferasirox; Humans; Iron Chelating Agents; Ophthalmic Solutions; Protein Kinase Inhibitors; Pyrazines; Pyrimidines; Randomized Controlled Trials as Topic; Skin Diseases; Skin Neoplasms; Thiazoles; Triazoles | 2007 |
Recent progress in the improvement of the coupling efficiency of "difficult sequences" in peptide synthesis.
Topics: Acylation; Amino Acid Sequence; Molecular Structure; Organophosphorus Compounds; Peptide Fragments; Peptides; Proline; Resins, Synthetic; Temperature; Thiazoles; Thiocyanates; Triazoles | 2007 |
Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder.
Topics: Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Depressive Disorder, Major; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Drug Resistance; Drug Therapy, Combination; Fluoxetine; Humans; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Serotonin 5-HT2 Receptor Antagonists; Thiazoles; Trazodone; Triazoles | 2008 |
Novel triazole antifungal drugs: focus on isavuconazole, ravuconazole and albaconazole.
Topics: Animals; Antifungal Agents; Clinical Trials as Topic; Drug Resistance, Fungal; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Nitriles; Pyridines; Quinazolines; Thiazoles; Triazoles | 2010 |
Onychomycosis.
Topics: Administration, Cutaneous; Administration, Oral; Antifungal Agents; Ciclopirox; Drug Administration Schedule; Drug Therapy, Combination; Fluconazole; Foot Dermatoses; Humans; Itraconazole; Mitosporic Fungi; Morpholines; Naphthalenes; Onychomycosis; Pyridones; Pyrimidines; Terbinafine; Thiazoles; Triazoles; Voriconazole | 2010 |
[Recent advances in the study of new antifungal lead compounds].
Topics: Antifungal Agents; Fungi; Heterocyclic Compounds; Humans; Lipopeptides; Molecular Structure; Mycoses; Nitriles; Plant Extracts; Plants, Medicinal; Pyridines; Quinazolines; Quinones; Structure-Activity Relationship; Thiazoles; Triazoles | 2010 |
Newer antifungal agents.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis, Invasive; Child; Clinical Trials as Topic; Half-Life; Humans; Lipopeptides; Nitriles; Pyridines; Quinazolines; Thiazoles; Triazoles | 2011 |
Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.
Topics: Acetamides; Animals; Azepines; Benzofurans; Humans; Isoquinolines; Models, Biological; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrimidines; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles; Wakefulness | 2014 |
[Pharmaceutical applications of sulfobuthylether-beta-cyclodextrin].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antiemetics; Antifungal Agents; Antipsychotic Agents; Aripiprazole; beta-Cyclodextrins; Chemistry, Pharmaceutical; Dosage Forms; Drug Stability; Humans; Hungary; Multiple Myeloma; Oligopeptides; Piperazines; Pyrimidines; Quinolones; Quinuclidines; Solubility; Thiazoles; Triazoles; Voriconazole | 2013 |
Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?
Topics: Acetamides; Animals; Azepines; Behavior, Addictive; Benzofurans; Feeding Behavior; Humans; Intracellular Signaling Peptides and Proteins; Isoquinolines; Mice; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Piperidines; Pyrimidines; Rats; Reward; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles | 2013 |
[Pharmacological characterization of metabotropic glutamate-receptor 1 antagonist for the treatment of schizophrenia].
Topics: Animals; Benzimidazoles; Drug Discovery; Humans; Isoindoles; Mice; Molecular Targeted Therapy; Naphthalenes; Protein Binding; Rats; Receptors, Metabotropic Glutamate; Schizophrenia; Thiazoles; Triazoles | 2013 |
New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease.
Topics: Acetates; Animals; Atherosclerosis; Chalcones; Cholesterol, HDL; Dyslipidemias; Fatty Liver; Fenofibrate; Humans; Insulin Resistance; Lipoproteins, HDL; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptors; Propionates; Quinolines; Sulfonamides; Thiazoles; Triazoles; Triglycerides | 2014 |
Emerging therapies for gout.
Topics: Acetamides; Adrenocorticotropic Hormone; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Benzodiazepines; Febuxostat; Gout; Gout Suppressants; Humans; Imino Furanoses; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Melanocortins; Phenylacetates; Polyethylene Glycols; Pyrimidinones; Recombinant Fusion Proteins; Thiazoles; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents | 2014 |
Psychopharmacology of chronic pain: a focus on antidepressants and atypical antipsychotics.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Bupropion; Chronic Pain; Humans; Mianserin; Mirtazapine; Olanzapine; Piperazines; Quetiapine Fumarate; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Thiazoles; Trazodone; Triazoles | 2016 |
New drugs 2016, part 1.
Topics: Aminobutyrates; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azabicyclo Compounds; Azepines; Benzazepines; Biphenyl Compounds; Ceftazidime; Drug Approval; Drug Combinations; Humans; Ivabradine; Morphinans; Polyethylene Glycols; Pyridines; Tetrazoles; Thiazoles; Triazoles; United States; United States Food and Drug Administration; Valsartan | 2016 |
Potential of Ravuconazole and its Prodrugs as the New OralTherapeutics for Onychomycosis.
Topics: Administration, Oral; Antifungal Agents; Arthrodermataceae; Candida; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Discovery; Humans; Onychomycosis; Prodrugs; Thiazoles; Triazoles | 2016 |
Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds.
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Drug Development; Female; Humans; Thiazoles; Thiosemicarbazones; Triazoles | 2022 |
9 trial(s) available for triazoles and thiazoles
| Article | Year |
|---|---|
A phase I/II randomized, double-blind, placebo-controlled, dose-ranging study evaluating the efficacy, safety and pharmacokinetics of ravuconazole in the treatment of onychomycosis.
Topics: Administration, Oral; Antifungal Agents; Double-Blind Method; Drug Administration Schedule; Foot Dermatoses; France; Humans; Nails; Ontario; Onychomycosis; Severity of Illness Index; Thiazoles; Treatment Outcome; Triazoles; United States | 2005 |
The effect of ravuconazole on the pharmacokinetics of nelfinavir in healthy male volunteers.
Topics: Adolescent; Adult; Anti-HIV Agents; Area Under Curve; Cytochrome P-450 CYP3A; Drug Interactions; Half-Life; Humans; Male; Middle Aged; Nelfinavir; Thiazoles; Triazoles | 2006 |
Voriconazole increases while itraconazole decreases plasma meloxicam concentrations.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Blood Coagulation; Cross-Over Studies; Cyclooxygenase 1; Cytochrome P-450 Enzyme System; Drug Interactions; Genotype; Half-Life; Humans; Itraconazole; Male; Meloxicam; Protein Binding; Pyrimidines; Thiazines; Thiazoles; Thromboxane B2; Triazoles; Voriconazole; Young Adult | 2009 |
Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia.
Topics: Adult; Aged; Colchicine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Thioglycolates; Triazoles; Uric Acid | 2014 |
CRM1 as a new therapeutic target for non-Hodgkin lymphoma.
Topics: Acrylamides; Acrylates; Animals; Antineoplastic Agents; Caspases; Cell Cycle Checkpoints; Down-Regulation; Exportin 1 Protein; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Karyopherins; Lymphoma, Non-Hodgkin; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Proteins; Proteolysis; Receptors, Cytoplasmic and Nuclear; Thiazoles; Triazoles; Xenograft Model Antitumor Assays | 2015 |
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Parasite Load; Placebos; Polymerase Chain Reaction; Prospective Studies; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2018 |
Clinical Drug-Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects.
Topics: Administration, Oral; Adult; Antifungal Agents; Biological Assay; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Metabolome; Onychomycosis; Prodrugs; Thiazoles; Triazoles; Young Adult | 2018 |
Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study.
Topics: Adult; Aged; Antifungal Agents; Double-Blind Method; Female; Foot Dermatoses; Humans; Male; Middle Aged; Onychomycosis; Prodrugs; Thiazoles; Treatment Outcome; Triazoles; Young Adult | 2018 |
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease.
Topics: Adolescent; Adult; Chagas Disease; DNA, Protozoan; Humans; Middle Aged; Monitoring, Physiologic; Nitroimidazoles; Parasite Load; Placebos; Real-Time Polymerase Chain Reaction; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2019 |
297 other study(ies) available for triazoles and thiazoles
| Article | Year |
|---|---|
Effect of chemicals used as nitrification inhibitors on the denitrification process.
Topics: Anaerobiosis; Aniline Compounds; Azides; Mercury; Nitrates; Organometallic Compounds; Pseudomonas; Pyridines; Pyrimidines; Soil Microbiology; Sulfanilamides; Thiazoles; Triazoles | 1976 |
Synthesis of carboxyalkylthio-triazoles and bicyclic derivatives with antiinflammatory and analgesic activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Edema; Lethal Dose 50; Mice; Pain Measurement; Rats; Structure-Activity Relationship; Superoxides; Thiazoles; Triazoles | 1992 |
Characterization of the antagonist activity of the PAF antagonists RP 59227 and WEB 2086 on elicited guinea pig peritoneal macrophages. Evidence for variable affinities and kinetics.
Topics: Animals; Azepines; Guinea Pigs; Humans; Kinetics; Macrophages; Male; Neutrophils; Peritoneum; Platelet Activating Factor; Pyridines; Superoxides; Thiazoles; Triazoles | 1992 |
Synthesis and biological activity of new heterocyclic structures: [1,3]thiazino[2,3-i]purine, thiazolo[3,2-c] [1,2,3]triazolo[4,5-e]pyrimidine and [1,2,3]triazolo [4', 5': 4,5] pyrimido[6,1-b][1,3]thiazine.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Antiviral Agents; Bacteria; Fungi; Isomerism; Microbial Sensitivity Tests; Purines; Pyrimidines; Thiazines; Thiazoles; Triazoles; Vero Cells; Viral Plaque Assay; Viruses | 1992 |
Lack of enantio-selectivity in the in vitro antitumour cytotoxicity and membrane-damaging activity of ether lipid SRI 62-834: further evidence for a non-receptor-mediated mechanism of action.
Topics: Antineoplastic Agents; Azepines; Cell Death; Cell Membrane; Furans; Humans; Phospholipid Ethers; Platelet Aggregation Inhibitors; Stereoisomerism; Tetrazolium Salts; Thiazoles; Triazoles; Tumor Cells, Cultured | 1992 |
Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor.
Topics: Animals; Azepines; Blood Pressure; Burns; Gastric Mucosa; Hemodynamics; Hemoglobins; Male; Oxygen; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Regional Blood Flow; Thiazoles; Thiazolidines; Triazoles | 1992 |
RP 59227, a novel PAF receptor antagonist: effects in guinea pig models of airway hyperreactivity.
Topics: Animals; Antigens; Azepines; Bronchial Hyperreactivity; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Guinea Pigs; Male; Ovalbumin; Platelet Activating Factor; Pyridines; Thiazoles; Triazoles | 1992 |
Benzo[b]thiophenes, Part I: Synthesis and antimicrobial activity of benzo[b]thienyl-1,3,4-oxadiazole, -1,2,4-triazoline, and -thiazoline derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida albicans; Microbial Sensitivity Tests; Oxadiazoles; Thiazoles; Thiophenes; Triazoles | 1992 |
The platelet activating factor receptor antagonist, RP 59227, blocks platelet activating factor receptors mediating liberation of reactive oxygen species in guinea pig macrophages and human polymorphonuclear leukocytes.
Topics: Animals; Azepines; Glyceryl Ethers; Guinea Pigs; Humans; Luminescent Measurements; Macrophages; Male; Neutrophils; Oxygen; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1991 |
Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist.
Topics: Animals; Azepines; Blood Platelets; Bronchoconstriction; Guinea Pigs; Humans; Injections, Intravenous; Leukopenia; Male; Mice; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thrombocytopenia; Triazoles | 1991 |
Pharmacological properties of YM461, a new orally active platelet-activating factor antagonist.
Topics: Administration, Oral; Animals; Azepines; Blood Platelets; Blood Pressure; Cell Membrane; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles | 1991 |
Ro 19-3704 directly inhibits immunoglobulin E-dependent mediator release by a mechanism independent of its platelet-activating factor antagonist properties.
Topics: Animals; Azepines; Diterpenes; Ginkgolides; Glyceryl Ethers; Histamine Release; Humans; Immunoglobulin E; Inositol Phosphates; L-Lactate Dehydrogenase; Lactones; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Substance P; Synovial Fluid; Thiazoles; Triazines; Triazoles; Tumor Cells, Cultured | 1990 |
Protective effect of SR 27417, a novel PAF antagonist, on lethal anaphylactic and endotoxin-induced shock in mice.
Topics: Anaphylaxis; Animals; Azepines; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Male; Mice; Mice, Inbred Strains; Ovalbumin; Platelet Activating Factor; Shock, Septic; Thiazoles; Triazoles | 1991 |
Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney.
Topics: Animals; Azepines; Diterpenes; Female; Gangliosides; Ginkgolides; In Vitro Techniques; Kidney; Kinetics; Lactones; Male; Perfusion; Platelet Activating Factor; Pyridines; Rabbits; Renal Circulation; Tachyphylaxis; Thiazoles; Time Factors; Triazoles | 1991 |
Platelet-leukocyte interaction in adhesion to endothelial cells induced by platelet-activating factor in vitro.
Topics: Adenine; Animals; Azepines; Blood Platelets; Cell Adhesion; Diterpenes; Endothelium, Vascular; Female; Ginkgolides; Humans; In Vitro Techniques; Lactones; Leukocytes; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Pregnancy; Rabbits; Thiazoles; Triazoles; Umbilical Veins | 1991 |
PAF-induced conjunctivitis in the rabbit is mediated by peptido-leukotrienes.
Topics: Animals; Azepines; Conjunctiva; Conjunctivitis; Cyclooxygenase Inhibitors; Dicarboxylic Acids; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indomethacin; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; Second Messenger Systems; Tetrazoles; Thiazoles; Thienopyridines; Triazoles | 1990 |
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Male; Metabolic Clearance Rate; Methylprednisolone; Piperazines; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Ticlopidine; Triazoles | 1991 |
Characterization of receptors for platelet-activating factor in guinea pig lung membranes.
Topics: Animals; Azepines; Cell Membrane; Female; Guinea Pigs; Kinetics; Lung; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1990 |
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil | 1990 |
Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups.
Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Benzhydryl Compounds; Chemical Phenomena; Chemistry; Female; Gonadotropins, Equine; Imidazoles; Microsomes; Molecular Structure; NADP; Ovary; Pyrazoles; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship; Thiazoles; Triazoles; X-Ray Diffraction | 1990 |
[Synthetic cephalosporins. IV. Synthesis and antibacterial activity of 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(O-substituted oxyimino)acetamido]-3-(1,2,3-triazol-1-yl)methyl-3-cephem-4-carboxylic acid and related compounds].
Topics: Animals; Bacteria; Cephalosporins; Drug Resistance, Microbial; Mice; Structure-Activity Relationship; Thiazoles; Triazoles | 1989 |
[Reactivity of 3-aryl-4-amino-5-mercapto-4H-1,2,4-triazoles: synthesis and biological evaluation of 3,6-diaryl derivatives of 7H-1,2,4-thiazole[3,4-b][1,3,4]thiadiazines, of 3-aryl-4-amino-5-carboxymethylthio-4H-1,2,4-triazoles].
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Male; Mice; Microbial Sensitivity Tests; Rats; Rats, Inbred Strains; Superoxides; Thiadiazines; Thiazines; Thiazoles; Triazoles | 1987 |
The antisecretory profile of action of the H2-receptor antagonists, famotidine, loxtidine, ranitidine and L-643,441 on the rat isolated gastric mucosa.
Topics: Animals; Bucladesine; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Methacholine Chloride; Methacholine Compounds; Ranitidine; Rats; Thiadiazoles; Thiazoles; Triazoles | 1987 |
Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan.
Topics: Animals; Azepines; Carrageenan; Leukocyte Count; Male; Platelet Activating Factor; Pleurisy; Pyridines; Rats; Rats, Inbred Strains; Thiazoles; Triazines; Triazoles; Zymosan | 1989 |
A new bithiazole derivative with intercalative properties.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; DNA; Hot Temperature; Intercalating Agents; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Thiazoles; Thymus Gland; Triazoles | 1986 |
Radioligand binding of antagonists of platelet-activating factor to intact human platelets.
Topics: Azepines; Binding Sites; Binding, Competitive; Blood Platelets; Humans; Kinetics; Platelet Activating Factor; Pyridines; Thiazoles; Triazines; Triazoles; Tritium | 1988 |
First enzyme of histidine biosynthesis and repression control of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium.
Topics: Amino Acids; Amino Acyl-tRNA Synthetases; Carbon Radioisotopes; Cell-Free System; Enzyme Repression; Histidine; Leucine; Mutation; Operon; Salmonella typhimurium; Thiazoles; Triazoles | 1974 |
[Studies on thiocyanation of heterocyclic compounds. IV. Syntheses of imidazo-(2,1-b)-1,3,4-thiadiazole and thiazolo(3,2-b)-s-triazole derivatives, and thiocyanation and bromination of their compounds].
Topics: Bromine; Chemical Phenomena; Chemistry; Imidazoles; Thiazoles; Triazoles | 1972 |
Radiation chemistry of nitrogen and sulfur heterocyclics.
Topics: Chromatography, Gas; Free Radicals; Heterocyclic Compounds; Imidazoles; Nitrogen; Pyrazines; Pyrazoles; Pyrimidines; Pyrroles; Radiochemistry; Sulfur; Tetrazoles; Thiazoles; Thiophenes; Triazines; Triazoles | 1973 |
Bicyclic triazoles. 1. 3-(2-Furyl)-5-phenylthiazolo-2,3-c)-s-triazole.
Topics: Animals; Blood Pressure; Bridged-Ring Compounds; Furans; Male; Rats; Rats, Inbred Strains; Stimulation, Chemical; Thiazoles; Triazoles | 1972 |
Synthesis and activity of some 1,2,4-triazolylthiazolidones.
Topics: Antiviral Agents; Chemical Phenomena; Chemistry; Thiazoles; Triazoles | 1971 |
Pteridines. 8. Some 2,4,7-triamino-6-heteroarylpteridines.
Topics: Chromatography, Paper; Furans; Hydrogen-Ion Concentration; Imidazoles; Oxazoles; Pteridines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Spectrum Analysis; Thiazoles; Thiophenes; Triazoles; Ultraviolet Rays | 1968 |
Steroids 23. Synthesis fo some ring A-fused heterocyclic steroids.
Topics: Anabolic Agents; Chemical Phenomena; Chemistry; Heterocyclic Compounds; Imidazoles; Oxazoles; Pyrazoles; Thiazoles; Triazoles | 1965 |
Derivatives of imidazole. II. Synthesis and reactions of imidazo[1,2-alpha]pyrimidines and other bi- and tricyclic imidazo derivatives with analgesic, antiinflammatory, antipyretic, and anticonvulsant activity.
Topics: Aminopyrine; Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Aspirin; Chemistry, Organic; Electrophysiology; Imidazoles; Mice; Organic Chemistry Phenomena; Phenylbutazone; Pyridazines; Pyrimidines; Rats; Thiazoles; Triazoles | 1966 |
The PETT series, a new class of potent nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase.
Topics: Animals; Antiviral Agents; Base Sequence; Benzodiazepines; Brain; Cattle; Cells, Cultured; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; HIV-1; Humans; Imidazoles; Intercalating Agents; Male; Molecular Sequence Data; Pyridines; Rats; Rats, Inbred F344; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Thiourea; Triazoles | 1995 |
Platelet-activating factor stimulates gastric acid secretion in isolated rabbit gastric glands.
Topics: Aminopyrine; Animals; Azepines; Biological Transport; Calcium; Carbachol; Dose-Response Relationship, Drug; Egtazic Acid; Famotidine; Fluorescent Dyes; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Rabbits; Thiazoles; Thienopyridines; Triazoles; Verapamil | 1995 |
Synthesis and biological activities of some 3,6-disubstituted thiazolo[3,2-b][1,2,4]triazoles.
Topics: Animals; Anticonvulsants; Antifungal Agents; Candida; Electroshock; Male; Mice; Microbial Sensitivity Tests; Pentylenetetrazole; Seizures; Spectrophotometry, Infrared; Thiazoles; Triazoles | 1995 |
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.
Topics: Animals; Azepines; Benzodiazepines; Imidazoles; Mice; Platelet Activating Factor; Pyridines; Rabbits; Structure-Activity Relationship; Thiazoles; Triazoles | 1995 |
Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones as potential platelet aggregation inhibitors.
Topics: Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Thiazoles; Triazoles | 1995 |
Yangambin: a new naturally-occurring platelet-activating factor receptor antagonist: in vivo pharmacological studies.
Topics: Animals; Antihypertensive Agents; Azepines; Blood Platelets; Female; Furans; Heart Rate; Leukocytes; Lignans; Male; Plants; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1995 |
The role of platelet-activating factor in lipopolysaccharide-induced myocardial depression in guinea pigs.
Topics: Animals; Azepines; Depression, Chemical; Drug Interactions; Escherichia coli; Female; Guinea Pigs; Isoproterenol; Lipopolysaccharides; Male; Myocardial Contraction; Phenylephrine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Time Factors; Triazoles | 1995 |
Synthesis of some 4-thiazoline and 4H-1,2,4-triazole derivatives of imidazo[1,2-a]pyridine as possible anticonvulsants.
Topics: Animals; Anticonvulsants; Magnetic Resonance Spectroscopy; Pyridines; Rats; Rats, Sprague-Dawley; Thiazoles; Triazoles | 1994 |
Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils.
Topics: Animals; Azepines; Binding, Competitive; Calcium; Cell Count; Cell Degranulation; Chemotaxis, Leukocyte; Free Radical Scavengers; Inositol 1,4,5-Trisphosphate; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Standards; Signal Transduction; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines; Triazoles; Vitamin E | 1994 |
Effect of platelet activating factor antagonists in different models of thrombosis.
Topics: Animals; Arterial Occlusive Diseases; Azepines; Cats; Diterpenes; Ginkgolides; Lactones; Male; Mice; Mice, Inbred Strains; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thiazoles; Thrombophlebitis; Triazoles | 1994 |
The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs.
Topics: Airway Resistance; Animals; Azepines; Chromones; Guinea Pigs; Histamine H1 Antagonists; Immunization; Lipoxygenase Inhibitors; Male; Ovalbumin; Phthalazines; Platelet Activating Factor; Pyrilamine; Rhinitis, Allergic, Perennial; Sneezing; SRS-A; Thiazoles; Thiazolidines; Triazoles | 1993 |
Endothelial cell-associated platelet-activating factor primes neutrophils for enhanced superoxide production and arachidonic acid release during adhesion to but not transmigration across IL-1 beta-treated endothelial monolayers.
Topics: Arachidonic Acid; Azepines; Cell Adhesion; Cell Movement; Cell Polarity; Endothelium, Vascular; Humans; In Vitro Techniques; Interleukin-1; Neutrophil Activation; Neutrophils; Piperazines; Platelet Activating Factor; Superoxides; Thiazoles; Thiazolidines; Triazoles | 1994 |
Preparation of C-(2-deoxyhex/pent-1-enopyranosyl)heterocycles.
Topics: Cyanides; Glycosides; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleosides; Optical Rotation; Oxadiazoles; Solvents; Stereoisomerism; Thiazoles; Triazoles | 1994 |
Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist.
Topics: Animals; Antioxidants; Azepines; Blood Glucose; Blood Platelets; Cattle; Diabetes Mellitus, Experimental; Free Radical Scavengers; Humans; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Mitochondria, Heart; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Superoxides; Sympathomimetics; Thiazoles; Thiobarbituric Acid Reactive Substances; Triazoles | 1993 |
Synthesis and vasodilatory activity of some thiazolo-triazole derivative.
Topics: Animals; Muscle, Smooth, Vascular; Sheep; Structure-Activity Relationship; Thiazoles; Triazoles; Vasodilation; Vasodilator Agents | 1993 |
Mechanism and regulation of neutrophil priming by platelet-activating factor.
Topics: Adult; Amiloride; Azepines; Calcium; Chelating Agents; Diacylglycerol Kinase; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphotransferases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyrimidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Thiazoles; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
Platelet-activating factor and the vascular effects of zymosan in rats.
Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Female; Hematocrit; Hemodynamics; Iodine Radioisotopes; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Triazoles; Zymosan | 1993 |
Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine.
Topics: Animals; Azepines; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Diseases; Intestinal Mucosa; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Thiazoles; Triazoles | 1996 |
Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils.
Topics: Azepines; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Endothelium, Vascular; Ginkgolides; Humans; Lactones; Leukocyte Elastase; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles | 1996 |
In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum.
Topics: Animals; Antifungal Agents; Aspergillosis; Candidiasis; Cryptococcosis; Female; Fluconazole; Fungi; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Thiazoles; Triazoles | 1996 |
Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis, and cryptococcosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Brain Diseases; Candidiasis; Candidiasis, Oral; Cryptococcosis; Female; Fluconazole; Lung Diseases, Fungal; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Rats; Rats, Sprague-Dawley; Thiazoles; Triazoles | 1996 |
Progress report on new antiepileptic drugs: a summary of the Third Eilat Conference.
Topics: Acetamides; Animals; Anticonvulsants; Azetidines; Carbamates; Drug Evaluation, Preclinical; Drugs, Investigational; Epilepsy; Humans; Israel; Levetiracetam; Nipecotic Acids; Phenylenediamines; Piracetam; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Thiazoles; Tiagabine; Triazoles | 1996 |
Species differences in PAF receptor binding in the lungs between hamster and guinea pig.
Topics: Animals; Azepines; Binding, Competitive; Cricetinae; Fibrinolytic Agents; Guinea Pigs; Kinetics; Ligands; Lung; Male; Mesocricetus; Organophosphorus Compounds; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Triazoles | 1997 |
Synthesis and antifungal activity of novel thiazole-containing triazole antifungals.
Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Candida; Candidiasis; Mice; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Structure-Activity Relationship; Thiazoles; Triazoles | 1997 |
Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Candida albicans; Escherichia coli; Microbial Sensitivity Tests; Quinoxalines; Staphylococcus aureus; Thiazoles; Triazoles | 1997 |
Assay for toxic chemicals using bacteria.
Topics: Bacteria; Coloring Agents; Culture Media; Minerals; Oxidation-Reduction; Platelet Aggregation Inhibitors; Rhizobium; Tetrazolium Salts; Thiazoles; Toxicity Tests; Triazoles | 1997 |
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Neutrophils; P-Selectin; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles | 1998 |
In vitro activity of a new oral triazole, BMS-207147 (ER-30346)
Topics: Amphotericin B; Antifungal Agents; Candida; Cryptococcus; Microbial Sensitivity Tests; Thiazoles; Triazoles | 1998 |
Synthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives.
Topics: Animals; Antifungal Agents; Candidiasis; Culture Media; Fungi; Mice; Microbial Sensitivity Tests; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 1998 |
New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candidiasis; Colony Count, Microbial; Fungi; Male; Mice; Molecular Conformation; Pyrimidinones; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles | 1998 |
Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.
Topics: Androstadienes; Animals; Azepines; Cell Adhesion Molecules; Cell Movement; Chromones; Colonic Neoplasms; Dogs; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Genes, src; GTP-Binding Proteins; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Kidney; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Thiazoles; Transformation, Genetic; Triazoles; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin | 1998 |
In vitro susceptibilities of Candida bloodstream isolates to the new triazole antifungal agents BMS-207147, Sch 56592, and voriconazole.
Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 1998 |
Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Topics: Anti-HIV Agents; Blood Proteins; Cell Line; HIV-1; Humans; Microbial Sensitivity Tests; Protein Binding; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Triazoles | 1998 |
Colorimetric MTT assessment of antifungal activity of D0870 against fluconazole-resistant Candida albicans.
Topics: Antifungal Agents; Candida albicans; Candidiasis; Colorimetry; Drug Resistance, Microbial; Fluconazole; Humans; Microbial Sensitivity Tests; Tetrazolium Salts; Thiazoles; Triazoles | 1998 |
In vitro susceptibilities of Candida dubliniensis isolates tested against the new triazole and echinocandin antifungal agents.
Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Candida; Candidiasis; Caspofungin; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 1999 |
Effects of histamine H2 receptor agonists and antagonists on the isolated guinea pig gallbladder.
Topics: Animals; Benzothiazoles; Dopamine Agents; Famotidine; Gallbladder; Guanidines; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Phenoxypropanolamines; Piperidines; Pyridines; Receptors, Histamine H2; Sincalide; Thiazoles; Triazoles | 1999 |
3-Cyclopropyl-1,2,4-triazolo[3,4-b]benzothiazole monohydrate.
Topics: Benzothiazoles; Crystallization; Crystallography, X-Ray; Hydrogen Bonding; Molecular Structure; Thiazoles; Triazoles | 1999 |
In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America.
Topics: Antifungal Agents; Candida; Dose-Response Relationship, Drug; Fluconazole; Humans; Itraconazole; Latin America; Microbial Sensitivity Tests; North America; Population Surveillance; Thiazoles; Triazoles | 1999 |
Augmentation of ultraviolet B radiation-induced tumor necrosis factor production by the epidermal platelet-activating factor receptor.
Topics: Azepines; Cells, Cultured; Humans; Indoles; Keratinocytes; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Thiazoles; Triazoles; Tumor Necrosis Factor-alpha; Ultraviolet Rays; Vitamin E | 1999 |
ER 30346. BMS 207147.
Topics: Animals; Antifungal Agents; Dogs; Drug Interactions; Drugs, Investigational; Fungi; Humans; Mycoses; Rats; Thiazoles; Triazoles | 1999 |
In vitro antifungal activity of BMS-207147 and itraconazole against yeast strains that are non-susceptible to fluconazole.
Topics: Antifungal Agents; Candida; Drug Resistance, Microbial; Fluconazole; Itraconazole; Microbial Sensitivity Tests; Thiazoles; Triazoles | 1999 |
Synthesis and evaluation of anti-inflammatory activity of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their Michael addition products.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Magnetic Resonance Spectroscopy; Male; Mice; Stomach Ulcer; Thiazoles; Triazoles | 1999 |
In vitro activity of the new triazole BMS-207147 against Aspergillus species in comparison with itraconazole and amphotericin B.
Topics: Amphotericin B; Antifungal Agents; Aspergillus; Drug Resistance, Microbial; Humans; Itraconazole; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2000 |
Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
Topics: Binding, Competitive; Crystallography, X-Ray; Deoxyguanine Nucleotides; DNA Primers; Dose-Response Relationship, Drug; HIV Reverse Transcriptase; Inhibitory Concentration 50; Intercalating Agents; Kinetics; Models, Chemical; Models, Molecular; Protein Binding; Pyridines; Regression Analysis; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thiazoles; Thiourea; Triazoles | 2000 |
Synthesis and biological evaluation of indole containing derivatives of thiosemicarbazide and their cyclic 1,2,4-triazole and 1,3,4-thiadiazole analogs.
Topics: Anti-Infective Agents; Antifungal Agents; Antiviral Agents; Bacteriophages; Lipids; Microbial Sensitivity Tests; Semicarbazides; Structure-Activity Relationship; Thiazoles; Triazoles | 2000 |
Interferon-gamma-induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis.
Topics: Adult; Azepines; Calcium; Cell Membrane; Cytotoxicity, Immunologic; Gene Expression; Humans; Interferon-gamma; Killer Cells, Natural; Membrane Glycoproteins; Neoplasms; Perforin; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pore Forming Cytotoxic Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Transfection; Triazoles; Tumor Cells, Cultured | 2000 |
R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents.
Topics: Animals; Aromatase Inhibitors; Benzothiazoles; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Epidermis; Female; Humans; Hyperplasia; Keratosis; Male; Mice; Ovariectomy; Rats; Rats, Wistar; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Tissue Distribution; Tretinoin; Triazoles; Vagina | 2000 |
In vitro activities of ravuconazole (BMS-207147) against 541 clinical isolates of Cryptococcus neoformans.
Topics: Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Fluconazole; Humans; Itraconazole; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2000 |
Efficacies of two new antifungal agents, the triazole ravuconazole and the echinocandin LY-303366, in an experimental model of invasive aspergillosis.
Topics: Anidulafungin; Animals; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Brain; Disease Models, Animal; Echinocandins; Liver; Lung; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles | 2000 |
NTZ for cryptosporidiosis: larger expanded access; buyers' club/FDA conflict. Food and Drug Administration.
Topics: Altruism; Clinical Trials as Topic; Consumer Organizations; Cryptosporidiosis; Drug Industry; Drugs, Investigational; Health Services Accessibility; Humans; Nitro Compounds; Thiazoles; Triazoles; United States; United States Food and Drug Administration | 1996 |
In vitro activities of four novel triazoles against Scedosporium spp.
Topics: Antifungal Agents; Humans; Microbial Sensitivity Tests; Pyrimidines; Quinazolines; Scedosporium; Thiazoles; Triazoles; Voriconazole | 2001 |
Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry, Physical; Edema; Female; Magnetic Resonance Spectroscopy; Male; Mice; Spectrophotometry, Infrared; Stomach Ulcer; Thiazoles; Triazoles | 2001 |
International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surv
Topics: Antifungal Agents; Candida; Candidiasis; Europe; Fluconazole; Fungemia; Humans; Latin America; North America; Pyrimidines; Sentinel Surveillance; Thiazoles; Triazoles; Voriconazole | 2001 |
Efficacy of ravuconazole in treatment of mucosal candidosis in SCID mice.
Topics: Administration, Oral; Animals; Antifungal Agents; Candidiasis, Chronic Mucocutaneous; Digestive System; Dose-Response Relationship, Drug; Female; Mice; Mice, SCID; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2001 |
Synthesis and evaluation of new triazolobenzothiazole derivatives as potential anti-tubercular agents.
Topics: Antitubercular Agents; Chemical Phenomena; Chemistry, Physical; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Spectrophotometry, Infrared; Thiazoles; Triazoles | 2001 |
Efficacy of ravuconazole (BMS-207147) in a guinea pig model of disseminated aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Male; Organ Culture Techniques; Organ Specificity; Thiazoles; Triazoles | 2002 |
Efficacy of ravuconazole in treatment of systemic murine histoplasmosis.
Topics: Animals; Antifungal Agents; Colony Count, Microbial; Female; Fluconazole; Histoplasmosis; Itraconazole; Liver; Mice; Spleen; Survival; Survival Analysis; Thiazoles; Triazoles | 2002 |
Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Canada; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Quality Control; Thiazoles; Triazoles; United States; Voriconazole | 2002 |
Penetration of ravuconazole, a new triazole antifungal, into rat tissues.
Topics: Administration, Oral; Animals; Antifungal Agents; Biological Availability; Female; Half-Life; Lung; Rats; Specific Pathogen-Free Organisms; Thiazoles; Triazoles; Uterus | 2002 |
Clinical evaluation of a frozen commercially prepared microdilution panel for antifungal susceptibility testing of seven antifungal agents, including the new triazoles posaconazole, ravuconazole, and voriconazole.
Topics: Antifungal Agents; Candida; Freezing; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2002 |
In vitro activities of ravuconazole and voriconazole compared with those of four approved systemic antifungal agents against 6,970 clinical isolates of Candida spp.
Topics: Antifungal Agents; Candida; Candidiasis; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2002 |
In vitro activity of three new triazoles and one echinocandin against Candida bloodstream isolates from cancer patients.
Topics: Antifungal Agents; Blood; Candida; Candidiasis; Echinocandins; Humans; In Vitro Techniques; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Neoplasms; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2002 |
Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; CD11c Antigen; CD4 Antigens; Cell Cycle; Cell Differentiation; Diacylglycerol Kinase; Enzyme Activators; Enzyme Inhibitors; Farnesol; Flow Cytometry; Genes, fos; Genes, jun; Humans; Immunoblotting; Isoenzymes; Leukemia, Myeloid; Naphthalenes; Oncogene Protein p21(ras); Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Sulfonamides; Thiazoles; Triazoles; Tumor Cells, Cultured | 2002 |
Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals.
Topics: Animals; Antifungal Agents; Aspergillus fumigatus; Azoles; Candida albicans; Candidiasis; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Itraconazole; Ketoconazole; Microbial Sensitivity Tests; Prodrugs; Rats; Solubility; Thiazoles; Triazoles | 2002 |
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Mice; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2003 |
In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis model.
Topics: Animals; Antifungal Agents; Area Under Curve; Candidiasis; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2003 |
Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin.
Topics: Animals; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Female; Lipopeptides; Lipoproteins; Lung; Lung Diseases, Fungal; Micafungin; Organ Size; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles | 2003 |
Patterning of motor neurons by retinoic acid in the chick embryo hindbrain in vitro.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endoderm; Gene Expression Regulation, Developmental; Homeodomain Proteins; In Situ Hybridization; In Vitro Techniques; LIM-Homeodomain Proteins; Mesoderm; Motor Neurons; Nerve Tissue Proteins; Retinoic Acid 4-Hydroxylase; Rhombencephalon; Thiazoles; Transcription Factors; Tretinoin; Triazoles | 2003 |
Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi.
Topics: Amphotericin B; Anti-Bacterial Agents; Aspergillus; Caspofungin; Echinocandins; Fungi; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Mycoses; Penicillium; Peptides; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2003 |
Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2,4-triazole)Ru(III) complexes.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Organometallic Compounds; Ruthenium; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles; Triazoles | 2003 |
Use of mercurated thiazoles as fungistatic agents.
Topics: Antifungal Agents; Fungicides, Industrial; Humans; Thiazoles; Triazoles | 1954 |
EFFECT ON CATALASE IN VIVO AND IN VITRO OF COMPOUNDS RELATED TO AMINOTRIAZOLE. ANL-6823.
Topics: Amitrole; Azides; Azoles; Catalase; Enzyme Inhibitors; Erythrocytes; Imidazoles; In Vitro Techniques; Isoniazid; Kidney; Liver; Oxadiazoles; Oxazoles; Oxidation-Reduction; Pentylenetetrazole; Pharmacology; Pyrazoles; Rats; Research; Thiazoles; Triazoles | 1964 |
BETA-HYDROXYPHENETHYLAMINO DERIVATIVES OF VARIOUS NITROGEN HETEROCYCLES.
Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antipyretics; Chemistry, Pharmaceutical; Hypnotics and Sedatives; Muscle Relaxants, Central; Nitrogen; Pharmacology; Phenethylamines; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Research; Thiazoles; Triazines; Triazoles | 1964 |
HETEROCYCLIC STEROIDS IN THE ANTIINFLAMMATORY SERIES.
Topics: Anti-Inflammatory Agents; Chemistry, Pharmaceutical; Imidazoles; Inflammation; Pharmacology; Pyrazoles; Pyrimidines; Research; Steroids; Steroids, Heterocyclic; Thiazoles; Triazoles | 1964 |
In vitro activities of new antifungal agents against Chaetomium spp. and inoculum standardization.
Topics: Antifungal Agents; Chaetomium; Colony Count, Microbial; Humans; Microbial Sensitivity Tests; Mitosporic Fungi; Pyrimidines; Reference Standards; Thiazoles; Triazoles; Voriconazole | 2003 |
Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties.
Topics: Animals; Antifungal Agents; Candidiasis; Drug Stability; Female; Humans; Indicators and Reagents; Infusions, Intravenous; Mice; Mice, Inbred ICR; Prodrugs; Rats; Solubility; Structure-Activity Relationship; Survival; Thiazoles; Triazoles | 2003 |
Synthesis of some functionalized arylaminomethyl-1 ,2,4-triazoles, 1,3,4-oxa- and thiadiazoles.
Topics: Antiviral Agents; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Hepatitis B virus; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methylation; Oxazoles; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Triazoles | 2003 |
Synthesis and in vitro antibacterial evaluation of novel imidazo[2',1':5,1]-1,2,4-triazolo[4,3-c]-quinazoline derivatives of 5-thioxo-1, 2, 4-triazole, 4-oxothiazolidine, and their open-chain counterparts.
Topics: Anti-Bacterial Agents; Colony Count, Microbial; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Quinazolines; Quinazolinones; Structure-Activity Relationship; Thiazoles; Triazoles | 2003 |
In vitro activity of ravuconazole against Zygomycetes, Scedosporium and Fusarium isolates.
Topics: Amphotericin B; Antifungal Agents; Fungi; Fusarium; Itraconazole; Microbial Sensitivity Tests; Pyrimidines; Scedosporium; Thiazoles; Triazoles; Voriconazole | 2003 |
Facile syntheses of oxazolines and thiazolines with N-acylbenzotriazoles under microwave irradiation.
Topics: Microwaves; Oxazoles; Thiazoles; Triazoles | 2004 |
In vitro interactions of licensed and novel antifungal drugs against Fusarium spp.
Topics: Amphotericin B; Antifungal Agents; Drug Interactions; Drug Resistance, Fungal; Fusarium; Humans; Itraconazole; Microbial Sensitivity Tests; Naphthalenes; Pyrimidines; Quinazolines; Sensitivity and Specificity; Terbinafine; Thiazoles; Triazoles; Voriconazole | 2004 |
Studies on the fungistatic powers of a new benzothiazol and an antihistaminic compound.
Topics: Antifungal Agents; Fungicides, Industrial; Histamine H1 Antagonists; Humans; Thiazoles; Triazoles | 1951 |
Synthesis and evaluation of in vitro antimycobacterial activity of some 5-(5-nitro-2-thienyl)-2-(piperazinyl, piperidinyl and morpholinyl)-1,3,4-thiadiazole derivatives.
Topics: Antitubercular Agents; Indicators and Reagents; Microbial Sensitivity Tests; Morpholines; Mycobacterium tuberculosis; Piperazines; Piperidines; Thiazoles; Triazoles | 2003 |
In vitro susceptibilities of rare Candida bloodstream isolates to ravuconazole and three comparative antifungal agents.
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Flucytosine; Fungemia; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2004 |
Synthesis, characterization and antiinflammatory-analgesic properties of 6-(alpha-amino-4-chlorobenzyl)thiazolo [3,2-b]-1,2,4-triazol-5-ols.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoquinones; Capillary Permeability; Carrageenan; Chemical Phenomena; Chemistry, Physical; Edema; Foot; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mice; Models, Molecular; Molecular Conformation; Naproxen; Pain; Spectroscopy, Fourier Transform Infrared; Stomach Ulcer; Structure-Activity Relationship; Thiazoles; Triazoles | 2004 |
Efficacy, safety, and plasma pharmacokinetics of escalating dosages of intravenously administered ravuconazole lysine phosphoester for treatment of experimental pulmonary aspergillosis in persistently neutropenic rabbits.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Dose-Response Relationship, Drug; Female; Galactose; Half-Life; Image Processing, Computer-Assisted; Immunosuppressive Agents; Injections, Intravenous; Lung; Mannans; Microbial Sensitivity Tests; Neutropenia; Rabbits; Survival Analysis; Tetrazolium Salts; Thiazoles; Tomography, X-Ray Computed; Triazoles | 2004 |
Synthesis and antifungal action of new tricyclazole analogues.
Topics: Botrytis; Fungicides, Industrial; Microscopy, Electron; Pyrazoles; Structure-Activity Relationship; Thiazoles; Triazoles | 2004 |
Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Naphthyridines; Neoplasm Transplantation; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Transplantation, Heterologous; Triazoles | 2004 |
Computational predictions of stereochemistry in asymmetric thiazolium- and triazolium-catalyzed benzoin condensations.
Topics: Benzoin; Catalysis; Models, Molecular; Molecular Structure; Stereoisomerism; Thiazoles; Triazoles | 2004 |
Effect of stereo and regiochemistry towards wild and multidrug resistant HIV-1 virus: viral potency of chiral PETT derivatives.
Topics: Anti-HIV Agents; Drug Resistance, Multiple; Drug Stability; HIV-1; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2004 |
Synthesis and biological evaluation of novel apio nucleosides with thiazole-4-carboxamide and 1,2,4-triazole-3-carboxamide.
Topics: Mannose; Nucleosides; Structure-Activity Relationship; Thiazoles; Triazoles | 2004 |
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.
Topics: Amino Acid Sequence; Anti-HIV Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thiazoles; Triazoles | 2004 |
Cross-resistance between fluconazole and ravuconazole and the use of fluconazole as a surrogate marker to predict susceptibility and resistance to ravuconazole among 12,796 clinical isolates of Candida spp.
Topics: Antifungal Agents; Candida; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2004 |
Density functional theory and ab initio studies of geometry, electronic structure and vibrational spectra of novel benzothiazole and benzotriazole herbicides.
Topics: Benzothiazoles; Data Interpretation, Statistical; Herbicides; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thiazoles; Triazoles | 2004 |
In vitro activities of ravuconazole and four other antifungal agents against fluconazole-resistant or -susceptible clinical yeast isolates.
Topics: Antifungal Agents; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles; Yeasts | 2004 |
Effects of several antifungal drug combinations against clinical and environmental isolates of Cryptococcus neoformans from China.
Topics: Animals; Antifungal Agents; Caspofungin; China; Columbidae; Cryptococcosis; Cryptococcus neoformans; Drug Interactions; Echinocandins; Feces; Flucytosine; Humans; Lipopeptides; Microbial Sensitivity Tests; Naphthalenes; Peptides; Peptides, Cyclic; Terbinafine; Thiazoles; Triazoles | 2004 |
Clinical evaluation of the Sensititre YeastOne colorimetric antifungal plate for antifungal susceptibility testing of the new triazoles voriconazole, posaconazole, and ravuconazole.
Topics: Antifungal Agents; Candida; Candidiasis; Humans; Microbial Sensitivity Tests; Pyrimidines; Reagent Kits, Diagnostic; Thiazoles; Triazoles; Voriconazole | 2004 |
In vitro antifungal susceptibility of Cryptococcus gattii.
Topics: Antifungal Agents; Cryptococcus; Cryptococcus neoformans; Humans; Microbial Sensitivity Tests; Quinazolines; Thiazoles; Triazoles | 2004 |
Influence of a thiazole derivative on ethanol and thermally oxidized sunflower oil-induced oxidative stress.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Ethanol; gamma-Glutamyltransferase; Lipid Peroxidation; Liver; Male; Oxidation-Reduction; Oxidative Stress; Plant Oils; Rats; Rats, Wistar; Sunflower Oil; Thiazoles; Triazoles | 2004 |
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.
Topics: Administration, Oral; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Hypotension; Hypothermia; Imidazoles; Mice; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2005 |
In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species.
Topics: Antifungal Agents; Arthrodermataceae; Fluconazole; Fungi; Humans; Itraconazole; Microbial Sensitivity Tests; Mycoses; Naphthalenes; Terbinafine; Thiazoles; Triazoles; Yeasts | 2005 |
Redifferentiation of human hepatoma cell induced by 6-(p-chlorophenyl)-3-[1-(p-chlorophenyl)-5-methyl-1 H-1,2,3-triazol-4-yl]-s-triazolo[3,4-b]-1,3,4-thiadiazole (TDZ).
Topics: alpha-Fetoproteins; Animals; Antineoplastic Agents; Cell Cycle; Cell Differentiation; Cell Survival; DNA, Neoplasm; Electrophoresis; Electrophysiology; Flow Cytometry; Humans; Liver Neoplasms, Experimental; Microscopy, Electron, Scanning; Sarcoma 180; Thiazoles; Thymidine; Triazoles; Tumor Cells, Cultured | 2005 |
Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Candida; Escherichia coli; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Staphylococcus aureus; Thiazoles; Triazoles | 2005 |
4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system.
Topics: Animals; Antineoplastic Agents; Binding Sites; Brain; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Microtubules; Mitotic Index; Protein Binding; Thiazoles; Triazoles; Tubulin | 2005 |
Synthesis and antituberculosis activity of new 3-alkylsulfanyl-1,2,4-triazole derivatives.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Chalcones; Culture Media; Microbial Sensitivity Tests; Models, Chemical; Mycobacterium tuberculosis; Oxazines; Temperature; Thiazoles; Triazoles; Xanthenes | 2005 |
In vitro activities of new and established triazoles against opportunistic filamentous and dimorphic fungi.
Topics: Antifungal Agents; Fungi; Humans; Microbial Sensitivity Tests; Mycoses; Pyrimidines; Species Specificity; Thiazoles; Triazoles; Voriconazole | 2005 |
Compartmental pharmacokinetics and tissue distribution of the antifungal triazole ravuconazole following intravenous administration of its di-lysine phosphoester prodrug (BMS-379224) in rabbits.
Topics: Adipose Tissue; Animals; Brain; Half-Life; Injections, Intravenous; Kidney; Liver; Lung; Lysine; Prodrugs; Rabbits; Thiazoles; Tissue Distribution; Triazoles | 2005 |
Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.
Topics: Algorithms; Analgesics; Animals; Behavior, Animal; Benzothiazoles; Brain; Cimetidine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Injections, Intraventricular; Male; Mice; Molecular Structure; Pain; Pain Measurement; Phenoxypropanolamines; Piperidines; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Triazoles | 2005 |
Advances in antifungal therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anidulafungin; Animals; Antifungal Agents; Caspofungin; Child; Child, Preschool; Clinical Trials as Topic; Echinocandins; Fungal Proteins; Humans; Infant; Infant, Newborn; Lipopeptides; Lipoproteins; Micafungin; Middle Aged; Mycoses; Peptides, Cyclic; Pyrimidines; Thiazoles; Treatment Outcome; Triazoles; Voriconazole | 2005 |
In vitro activity of ravuconazole against 923 clinical isolates of nondermatophyte filamentous fungi.
Topics: Antifungal Agents; Fungi; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2005 |
Efficient microwave enhanced regioselective synthesis of a series of benzimidazolyl/triazolyl spiro [indole-thiazolidinones] as potent antifungal agents and crystal structure of spiro[3H-indole-3,2'-thiazolidine]-3'(1,2,4-triazol-3-yl)-2,4'(1H)-dione.
Topics: Antifungal Agents; Benzimidazoles; Colletotrichum; Crystallization; Fusarium; Indoles; Microwaves; Models, Molecular; Molecular Structure; Rhizoctonia; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidines; Triazoles; X-Ray Diffraction | 2006 |
The design of orally active iron chelators.
Topics: Administration, Oral; Benzoates; Clinical Trials as Topic; Deferasirox; Dihydropyridines; Drug Design; Drug Evaluation, Preclinical; Humans; Iron; Iron Chelating Agents; Ligands; Models, Molecular; Molecular Structure; Oxidation-Reduction; Pyridones; Thiazoles; Triazoles | 2005 |
In vitro activities of new and conventional antimycotics against fluconazole-susceptible and non-susceptible Brazilian Candida spp. isolates.
Topics: Antifungal Agents; Brazil; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sensitivity Tests; Quinazolines; Thiazoles; Triazoles | 2006 |
Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Drug Antagonism; Drug Therapy, Combination; Humans; Liposomes; Lung Diseases, Fungal; Microbial Sensitivity Tests; Models, Biological; Polyenes; Rabbits; Thiazoles; Triazoles | 2006 |
Antifungal susceptibilities of the species of the Pseudallescheria boydii complex.
Topics: Amphotericin B; Antifungal Agents; Candida; Drug Resistance, Fungal; Echinocandins; Fluconazole; Flucytosine; Humans; Itraconazole; Ketoconazole; Lipopeptides; Lipoproteins; Micafungin; Microbial Sensitivity Tests; Naphthalenes; Peptides, Cyclic; Pseudallescheria; Pyrimidines; Quality Control; Quinazolines; Scedosporium; Terbinafine; Thiazoles; Triazoles; Voriconazole | 2006 |
Multi-azole resistance in Aspergillus fumigatus.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Caspofungin; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple, Fungal; Echinocandins; Fungal Proteins; Humans; Itraconazole; Lipopeptides; Lung Diseases, Fungal; Male; Microbial Sensitivity Tests; Middle Aged; Mutation, Missense; Peptides, Cyclic; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2006 |
Predicting anti-HIV activity of PETT derivatives: CoMFA approach.
Topics: Anti-HIV Agents; Computational Biology; Drug Design; Humans; Models, Molecular; Quantitative Structure-Activity Relationship; Reverse Transcriptase Inhibitors; Static Electricity; Thiazoles; Thiourea; Triazoles | 2007 |
Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC).
Topics: Animals; Benzimidazoles; Binding, Competitive; Calcium Signaling; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Inositol Phosphates; Male; Mice; Mice, Inbred ICR; Molecular Structure; Motor Activity; Naphthalenes; Point Mutation; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Thiazoles; Transfection; Triazoles | 2007 |
Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Alcohol Drinking; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Ethanol; Extinction, Psychological; Glutamic Acid; Models, Animal; Motor Activity; Pyridines; Pyrimidines; Rats; Rats, Inbred Strains; Reaction Time; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Self Administration; Thiazoles; Time Factors; Triazoles; Xanthines | 2008 |
Novel regioselective formation of S- and N-hydroxyl-alkyls of 5-(3-chlorobenzo[b]thien-2-yl)-3-mercapto-4H-1,2,4-triazole and a facile synthesis of triazolo-thiazoles and thiazolo-triazoles. Role of catalyst and microwave.
Topics: Alkylation; Catalysis; Ethanol; Microwaves; Sodium Acetate; Stereoisomerism; Thiazines; Thiazoles; Triazoles | 2007 |
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Topics: Aminopeptidases; Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Capillaries; Cell Proliferation; Crystallography, X-Ray; Endothelial Cells; Endothelium, Vascular; Furans; In Vitro Techniques; Male; Metalloendopeptidases; Models, Molecular; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles | 2007 |
Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
Topics: Amyloidosis; Benzamides; Benzothiazoles; Cell Line; Cell Survival; Cross-Linking Reagents; Drug Design; Fluorescence; Glutaral; Humans; Kinetics; Models, Molecular; Oxadiazoles; Phenyl Ethers; Prealbumin; Protein Denaturation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Thiazoles; Triazoles; Tryptophan | 2007 |
Selective regulation of neurosteroid biosynthesis in human neuroblastoma cells under hydrogen peroxide-induced oxidative stress condition.
Topics: Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Letrozole; Neuroblastoma; Nitriles; Oxidative Stress; Serum; Steroids; Tetrazolium Salts; Thiazoles; Time Factors; Triazoles | 2008 |
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Adipose Tissue; Animals; Cortisone; Crystallography, X-Ray; Diabetes Mellitus, Type 2; Humans; Hydrocortisone; Hypoglycemic Agents; Ligands; Liver; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2008 |
Antioxidant activity of an aminothiazole compound: possible mechanisms.
Topics: Animals; Antioxidants; DNA; DNA Damage; Female; Free Radical Scavengers; Lipid Peroxidation; Mitochondria, Liver; Molecular Structure; Oxidation-Reduction; Proteins; Rats; Rats, Wistar; Thiazoles; Triazoles | 2008 |
Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.
Topics: Amino Acid Substitution; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Azoles; Cytochrome P-450 Enzyme System; Drug Resistance, Fungal; Fungal Proteins; Genes, Fungal; Humans; Itraconazole; Microbial Sensitivity Tests; Molecular Epidemiology; Molecular Sequence Data; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2008 |
Nonclinical pharmacokinetics of BMS-292655, a water-soluble prodrug of the antifungal ravuconazole.
Topics: Animals; Antifungal Agents; Blood Proteins; Dogs; Humans; Hydrolysis; In Vitro Techniques; Macaca fascicularis; Male; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Thiazoles; Triazoles | 2008 |
MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands.
Topics: Anastrozole; Aromatase Inhibitors; Biological Assay; Cell Line, Tumor; Coumarins; ERRalpha Estrogen-Related Receptor; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Fulvestrant; Genes, Reporter; Genistein; Humans; Letrozole; Ligands; Luciferases; Nitriles; Receptors, Estrogen; Response Elements; Tamoxifen; Thiazoles; Transfection; Triazoles | 2008 |
Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives.
Topics: Animals; Anti-Obesity Agents; CHO Cells; Cricetinae; Cricetulus; Humans; Imidazoles; Isomerism; Models, Chemical; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Solubility; Structure-Activity Relationship; Thiazoles; Triazoles; Water | 2008 |
Synthesis, analgesic, anti-inflammatory and antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles.
Topics: Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Microbial Sensitivity Tests; Spectrum Analysis; Structure-Activity Relationship; Thiazoles; Triazoles | 2009 |
Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: results of a 3-year (2004 to 2007) surveillance study.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Candida; Candida albicans; Candida glabrata; Candida tropicalis; Candidiasis; Caspofungin; Child; Child, Preschool; Echinocandins; Female; Fluconazole; Humans; Infant; Infant, Newborn; Itraconazole; Lipopeptides; Male; Mexico; Microbial Sensitivity Tests; Middle Aged; Pyrimidines; Thiazoles; Triazoles; Voriconazole; Young Adult | 2008 |
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles | 2008 |
Effects of a hindered amine light stabilizer and a UV light absorber used in maxillofacial elastomers on human gingival epithelial cells and fibroblasts.
Topics: Cell Line; Cell Membrane; Cell Proliferation; Cell Survival; Colorimetry; Coloring Agents; Decanoic Acids; Epithelial Cells; Fibroblasts; Gingiva; Humans; L-Lactate Dehydrogenase; Materials Testing; Maxillofacial Prosthesis; Piperidines; Silicone Elastomers; Spectrophotometry; Tetrazolium Salts; Thiazoles; Time Factors; Triazoles | 2008 |
Synthesis, antibacterial and antifungal activities of 3-(1,2,4-triazol-3-yl)-4-thiazolidinones.
Topics: Anti-Bacterial Agents; Antifungal Agents; Microbial Sensitivity Tests; Schiff Bases; Sulfhydryl Compounds; Thiazoles; Thioglycolates; Triazoles | 2009 |
First synthesis of non-symmetrical "phthalimidoyl active ester" bi-dentate cross-linking reagents having an acid chloride, 2-benzothiazole, or 1-benzotriazol group.
Topics: Antigens; Benzylamines; Chlorides; Cholesterol; Cross-Linking Reagents; Esters; Phthalimides; Proteins; Substrate Specificity; Thiazoles; Triazoles | 2008 |
On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
Topics: Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Bezafibrate; Cell Line, Tumor; Fenofibrate; Fibroblasts; Gemfibrozil; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pioglitazone; PPAR delta; PPAR gamma; Propionates; Thiazoles; Thiazolidinediones; Triazoles | 2009 |
Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase.
Topics: Activating Transcription Factor 2; Animals; Binding Sites; Diabetes Mellitus, Type 2; Drug Design; HeLa Cells; Humans; Hypoglycemic Agents; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Mice; Phosphorylation; Protein Binding; Structure-Activity Relationship; Substrate Specificity; Thiadiazoles; Thiazoles; Triazoles | 2009 |
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
Topics: Administration, Oral; Animals; Antimalarials; Dihydroorotate Dehydrogenase; Humans; In Vitro Techniques; Malaria; Male; Mice; Microsomes, Liver; Models, Molecular; Oxidoreductases Acting on CH-CH Group Donors; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimidines; Structure-Activity Relationship; Thiazoles; Triazoles | 2009 |
Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type I; Female; Humans; Indoles; Leukemia; Quinolines; Thiazoles; Topoisomerase I Inhibitors; Triazoles | 2009 |
In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes.
Topics: Amphotericin B; Antifungal Agents; Azoles; Cyclosporine; Drug Interactions; Immunosuppressive Agents; Itraconazole; Microbial Sensitivity Tests; Mucorales; Rhizopus; Sirolimus; Tacrolimus; Thiazoles; Triazoles | 2009 |
2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.
Topics: Computer Simulation; Crystallography, X-Ray; Drug Design; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Telomere; Thiazoles; Transition Temperature; Triazoles | 2009 |
Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Cerulenin; Cluster Analysis; Fatty Acid Desaturases; Fatty Acids, Unsaturated; Fungal Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Hyphae; Male; Mice; Mice, Inbred ICR; Molecular Structure; Mutation; Stearoyl-CoA Desaturase; Survival Rate; Thiazoles; Time Factors; Triazoles; Virulence | 2009 |
QSAR study of PETT derivatives as potent HIV-1 reverse transcriptase inhibitors.
Topics: Enzyme Inhibitors; HIV Reverse Transcriptase; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Thiazoles; Triazoles | 2009 |
In silico study of naphtha [1, 2-d] thiazol-2-amine with adenosine A 2A receptor and its role in antagonism of haloperidol-induced motor impairments in mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Dopamine; Haloperidol; Humans; Male; Mice; Models, Molecular; Motor Activity; Movement Disorders; Naphthalenes; Receptor, Adenosine A2A; Thiazoles; Triazoles | 2009 |
Trial renews interest in Chagas' disease.
Topics: Chagas Disease; Clinical Trials, Phase I as Topic; Drug Industry; Global Health; Humans; Latin America; Prodrugs; Research Support as Topic; Thiazoles; Triazoles | 2009 |
Synthesis and biological activity of pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives: in silico approach.
Topics: Computational Biology; Drug Design; Enzyme Inhibitors; Expert Systems; Gout Suppressants; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrimidinones; Spectrophotometry, Infrared; Thiazoles; Triazoles; Xanthine Oxidase | 2010 |
New Drugs2010, PART 1.
Topics: Acetamides; Antibodies, Monoclonal; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Azepines; Benzazepines; Benzhydryl Compounds; Benzyl Alcohol; Benzylamines; Cyclams; Cyclopropanes; Drug Combinations; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Ethanolamines; Everolimus; Febuxostat; Fluorenes; Fluoroquinolones; Gout Suppressants; Heterocyclic Compounds; Humans; Immunosuppressive Agents; Indoles; Lacosamide; Milnacipran; Oligopeptides; Phenols; Selective Serotonin Reuptake Inhibitors; Sirolimus; Tapentadol; Thiazoles; Tolvaptan; Triazoles | 2010 |
Linear and nonlinear optical susceptibilities of 3-phenylamino-4-phenyl-1,2,4-triazole-5-thione.
Topics: Algorithms; Models, Chemical; Thiazoles; Thiones; Triazoles; X-Ray Diffraction | 2010 |
Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2010 |
Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.
Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Carboxylic Acids; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Oligopeptides; Thiazoles; Triazoles | 2010 |
Synthesis and dual PPARalpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516.
Topics: Animals; Chlorocebus aethiops; COS Cells; Humans; PPAR alpha; PPAR delta; Thiazoles; Triazoles | 2010 |
Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Interferon-gamma; Interleukin-10; Myocardium; Polymerase Chain Reaction; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Humans; Oxidoreductases, N-Demethylating; Oximes; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Rifampin; RNA, Messenger; Thiazoles; Transcriptional Activation; Transfection; Triazoles | 2010 |
Drug metabolism and pharmacokinetics of 4-substituted methoxybenzoyl-aryl-thiazoles.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dogs; Drug Stability; Half-Life; Humans; Male; Metabolic Clearance Rate; Mice; Mice, Inbred ICR; Microsomes, Liver; Predictive Value of Tests; Protein Binding; Rats; Rats, Sprague-Dawley; Small Molecule Libraries; Species Specificity; Thiazoles; Triazoles; Tubulin Modulators | 2010 |
Synthesis, biological evaluation and molecular modeling studies of N-aryl-2-arylthioacetamides as non-nucleoside HIV-1 reverse transcriptase inhibitors.
Topics: Binding Sites; Cell Line; Computer Simulation; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Thiazoles; Thioacetamide; Triazoles | 2010 |
In vitro and in vivo antifungal susceptibilities of the Mucoralean fungus Cunninghamella.
Topics: Amphotericin B; Animals; Antifungal Agents; Caspofungin; Cunninghamella; Diabetes Mellitus, Experimental; Echinocandins; Itraconazole; Lipopeptides; Male; Mice; Microbial Sensitivity Tests; Mucormycosis; Pyrimidines; Thiazoles; Triazoles; Voriconazole | 2010 |
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
Topics: Casein Kinase II; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dasatinib; HeLa Cells; Humans; Immunoblotting; Jurkat Cells; Karyotyping; Liposarcoma, Myxoid; NF-kappa B; Oncogene Proteins, Fusion; Protein Kinase Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Triazoles | 2010 |
Significance of ER-Src axis in hormonal therapy resistance.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Co-Repressor Proteins; Dasatinib; Drug Resistance, Neoplasm; Drug Synergism; Estrogen Receptor alpha; Female; Gene Knockdown Techniques; Humans; Letrozole; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pyrimidines; Receptor, ErbB-2; RNA Interference; src-Family Kinases; Tamoxifen; Thiazoles; Transcription Factors; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Effect of pesticides on plant growth promoting traits of greengram-symbiont, Bradyrhizobium sp. strain MRM6.
Topics: Alanine; Bradyrhizobium; Dose-Response Relationship, Drug; Fabaceae; Fungicides, Industrial; Glycine; Glyphosate; Herbicides; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Organothiophosphorus Compounds; Oxazines; Symbiosis; Thiamethoxam; Thiazoles; Triazines; Triazoles | 2011 |
mGlu5 and adenosine A2A receptor interactions regulate the conditioned effects of cocaine.
Topics: Analysis of Variance; Animals; Autoradiography; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Drug Interactions; Excitatory Amino Acid Antagonists; Iodine Isotopes; Locomotion; Male; Mice; Mice, Knockout; Protein Binding; Pyridines; Radionuclide Imaging; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles; Time Factors; Triazines; Triazoles | 2012 |
An approach for rapid development of nasal delivery of analgesics--identification of relevant features, in vitro screening and in vivo verification.
Topics: Absorption; Administration, Intranasal; Administration, Oral; Analgesics; Animals; Area Under Curve; Benzopyrans; Cell Line; Drug Stability; Ethanolamines; Feasibility Studies; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Male; Meloxicam; Nasal Mucosa; Nebivolol; Permeability; Piroxicam; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Respiratory Mucosa; Thiazines; Thiazoles; Triazoles; Tryptamines | 2011 |
Protective effect of an aminothiazole compound against γ-radiation induced oxidative damage.
Topics: Animals; Apoptosis; DNA Damage; Female; Gamma Rays; Humans; Indoles; Lipid Peroxidation; Lymphocytes; Mice; Mitochondria, Liver; Oxidative Stress; Radiation-Protective Agents; Rats; Rats, Wistar; Spleen; Thiadiazoles; Thiazoles; Triazoles | 2011 |
Toxicological assessment of selective pesticides towards plant growth promoting activities of phosphate solubilizing Pseudomonas aeruginosa.
Topics: Brassica; Dose-Response Relationship, Drug; Herbicides; Imidazoles; Neonicotinoids; Nitro Compounds; Oxazines; Pesticides; Phosphates; Pseudomonas aeruginosa; Rhizobium; Rhizosphere; RNA, Bacterial; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Siderophores; Soil Microbiology; Soil Pollutants; Thiamethoxam; Thiazoles; Triazines; Triazoles | 2011 |
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Topics: Acetylcholinesterase; Alzheimer Disease; Azo Compounds; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Indoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Piperidines; Spiro Compounds; Structure-Activity Relationship; Temperature; Thiazoles; Thiosemicarbazones; Triazoles | 2012 |
Diaminothiazoles inhibit angiogenesis efficiently by suppressing Akt phosphorylation.
Topics: Angiogenesis Inhibitors; Animals; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Cyclin-Dependent Kinases; Human Umbilical Vein Endothelial Cells; Humans; Microtubules; Neovascularization, Pathologic; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiazoles; Triazoles; Vascular Endothelial Growth Factor A | 2012 |
Design and synthesis of new 4-pyrazolin-3-yl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolin-1-ylthiazoles as potential antimicrobial agents.
Topics: Anti-Infective Agents; Chemistry Techniques, Synthetic; Drug Design; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2012 |
Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring.
Topics: Animals; Chemistry Techniques, Synthetic; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Hypolipidemic Agents; Male; Oxadiazoles; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Triazoles | 2012 |
Hybrids of ravuconazole: synthesis and biological evaluation.
Topics: Anti-Infective Agents; Aspergillus niger; Bacteria; Candida albicans; Chemistry Techniques, Synthetic; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2012 |
Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia.
Topics: Acrylamides; Acrylates; Acute Disease; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Drug Evaluation, Preclinical; Exportin 1 Protein; Female; fms-Like Tyrosine Kinase 3; Humans; Kaplan-Meier Estimate; Karyopherins; Leukemia, Myeloid; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Receptors, Cytoplasmic and Nuclear; Thiazoles; Triazoles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays; Young Adult | 2012 |
Increasing human Th17 differentiation through activation of orphan nuclear receptor retinoid acid-related orphan receptor γ (RORγ) by a class of aryl amide compounds.
Topics: Amides; Benzamides; Cell Differentiation; Circular Dichroism; Genes, Reporter; Humans; Interleukin-17; Jurkat Cells; Nuclear Receptor Subfamily 1, Group F, Member 3; Primary Cell Culture; Protein Stability; Structure-Activity Relationship; T-Lymphocytes; Th17 Cells; Thiazoles; Triazoles | 2012 |
On the organocatalytic activity of N-heterocyclic carbenes: role of sulfur in thiamine.
Topics: Aldehydes; Benzoin; Catalysis; Heterocyclic Compounds; Imidazoles; Methane; Molecular Structure; Quantum Theory; Sulfur; Thiamine; Thiazoles; Triazoles | 2012 |
Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis.
Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Molecular Structure; Structure-Activity Relationship; Thiazoles; Triazoles | 2012 |
Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Neoplasms; Structure-Activity Relationship; Thiazoles; Triazoles | 2012 |
Rationalization of physico-chemical properties of 5, 6-diarylthiazolo [3,2-b]-1, 2, 4-triazoles towards cyclooxygenase-2 (COX-2) inhibition: a QSAR approach.
Topics: Anti-Inflammatory Agents; Catalytic Domain; Chemistry, Pharmaceutical; Chemistry, Physical; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Design; Electrochemistry; Humans; Inhibitory Concentration 50; Models, Chemical; Models, Theoretical; Quantitative Structure-Activity Relationship; Thiazoles; Triazoles | 2004 |
Cu-catalyzed direct C-H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles.
Topics: Catalysis; Copper; Models, Molecular; Molecular Structure; Organometallic Compounds; Stereoisomerism; Thiazoles; Triazoles | 2013 |
Upregulation of DR5 receptor by the diaminothiazole DAT1 [4-amino-5-benzoyl-2-(4-methoxy phenyl amino) thiazole] triggers an independent extrinsic pathway of apoptosis in colon cancer cells with compromised pro and antiapoptotic proteins.
Topics: Apoptosis; bcl-Associated Death Protein; Caspase 8; Colonic Neoplasms; Down-Regulation; HCT116 Cells; Humans; Mitochondria; Receptors, TNF-Related Apoptosis-Inducing Ligand; Serpins; Thiazoles; Triazoles; Up-Regulation; Viral Proteins | 2013 |
Transannulation of 1-sulfonyl-1,2,3-triazoles with heterocumulenes.
Topics: Catalysis; Imidazoles; Isocyanates; Isothiocyanates; Methane; Polyenes; Rhodium; Sulfinic Acids; Thiazoles; Triazoles | 2013 |
Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors.
Topics: Biological Assay; Glycine max; Herbicides; Molecular Docking Simulation; Plant Proteins; Plant Weeds; Protoporphyrinogen Oxidase; Species Specificity; Structure-Activity Relationship; Sulfonamides; Thiazoles; Triazoles | 2013 |
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists.
Topics: Adenosine A2 Receptor Antagonists; Animals; Drug Design; HEK293 Cells; Humans; Male; Mice; Models, Biological; Molecular Structure; Protein Binding; Pyrimidines; Receptor, Adenosine A2A; Thiazoles; Triazoles | 2013 |
Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
Topics: 14-alpha Demethylase Inhibitors; Antiprotozoal Agents; Chagas Disease; Crystallography, X-Ray; Humans; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanosoma cruzi | 2013 |
Dasatinib-letrozole gets split verdict.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Dasatinib; Female; Humans; Letrozole; Nitriles; Protein Kinase Inhibitors; Pyrimidines; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles; Treatment Outcome; Triazoles | 2014 |
Concise and scalable asymmetric synthesis of 5-(1-amino-2,2,2-trifluoroethyl)thiazolo[3,2-b][1,2,4]triazoles.
Topics: Models, Molecular; Molecular Structure; Stereoisomerism; Thiazoles; Triazoles | 2014 |
Host biomarkers of invasive pulmonary aspergillosis to monitor therapeutic response.
Topics: Amphotericin B; Animals; Annexin A1; Antifungal Agents; Aspergillus fumigatus; Biomarkers; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Invasive Pulmonary Aspergillosis; Neutropenia; Proteomics; Rabbits; Thiazoles; Triazoles | 2014 |
Treat to target in gout by combining two modes of action.
Topics: Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thiazoles; Thioglycolates; Triazoles | 2014 |
A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).
Topics: Animals; Binding Sites; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Humans; Kinetics; Mice; Models, Molecular; Protein Conformation; Pyrazoles; Rats; S-Adenosylmethionine; Structure-Activity Relationship; Thiazoles; Triazoles | 2014 |
AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Isoxazoles; Male; Oxadiazoles; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazoles | 2014 |
Molecular structure, vibrational and electronic properties of 4-Phenyl-3H-1,3-thiazol-2-ol using density functional theory and comparison of drug efficacy of keto and enol forms by QSAR analysis.
Topics: Electrons; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Quantum Theory; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Stereoisomerism; Thermodynamics; Thiazoles; Triazoles; Vibration | 2014 |
Madurella mycetomatis is highly susceptible to ravuconazole.
Topics: Antifungal Agents; Itraconazole; Ketoconazole; Madurella; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2014 |
Homo- and heteroleptic bismuth(III/V) thiolates from N-heterocyclic thiones: synthesis, structure and anti-microbial activity.
Topics: Animals; Anti-Infective Agents; Bismuth; Chlorocebus aethiops; Coordination Complexes; COS Cells; Imidazoles; Microbial Sensitivity Tests; Structure-Activity Relationship; Sulfhydryl Compounds; Thiazoles; Thiones; Triazoles | 2014 |
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Exportin 1 Protein; Glioblastoma; Humans; Hydrazines; Karyopherins; Macaca fascicularis; Male; Mice; Oxadiazoles; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays | 2015 |
Androgen receptor antagonists and anti-prostate cancer activities of some newly synthesized substituted fused pyrazolo-, triazolo- and thiazolo-pyrimidine derivatives.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; CHO Cells; Cricetulus; Humans; Lethal Dose 50; Male; Prostatic Neoplasms; Pyrazoles; Pyrimidines; Thiazoles; Triazoles | 2014 |
Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 9; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A1; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Pyrimidines; Structure-Activity Relationship; Thiazoles; Triazoles | 2015 |
Synthesis and cytotoxicity evaluation of some novel thiazoles, thiadiazoles, and pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones incorporating triazole moiety.
Topics: Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Spectrophotometry, Infrared; Structure-Activity Relationship; Thiadiazoles; Thiazoles; Triazoles | 2015 |
[In vitro antifungal activity of ravuconazole against isolates of dermatophytes and Candida species from patients with dermatomycoses].
Topics: Antifungal Agents; Arthrodermataceae; Candida; Dermatomycoses; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Humans; Itraconazole; Naphthalenes; Terbinafine; Thiazoles; Triazoles | 2014 |
Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice.
Topics: Animals; Apoptosis; Azepines; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Everolimus; Homeodomain Proteins; Imidazoles; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Quinolines; Signal Transduction; Thiazoles; Transcription, Genetic; Triazoles; Vincristine | 2015 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Design; Edema; Humans; Inflammation; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Naproxen; Nociception; Pain; Pain Measurement; Structure-Activity Relationship; Thiazoles; Thiones; Triazoles | 2015 |
High Efficiency Antimicrobial Thiazolium and Triazolium Side-Chain Polymethacrylates Obtained by Controlled Alkylation of the Corresponding Azole Derivatives.
Topics: Alkylation; Anti-Infective Agents; Polymethacrylic Acids; Pseudomonas aeruginosa; Staphylococcus aureus; Thiazoles; Triazoles | 2015 |
Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Exportin 1 Protein; G1 Phase Cell Cycle Checkpoints; Humans; Hydrazines; Inhibitor of Apoptosis Proteins; Karyopherins; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mice; Mice, SCID; Neoplasm Proteins; Oxadiazoles; Peritoneal Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Survivin; Thiazoles; Triazoles; Tumor Suppressor Protein p53 | 2015 |
New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII.
Topics: Benzenesulfonamides; Binding Sites; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Enzyme Activation; Humans; Isoenzymes; Models, Biological; Molecular Structure; Sulfonamides; Thiazoles; Triazoles | 2015 |
Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.
Topics: Adjuvants, Pharmaceutic; Anastrozole; Anilides; Animals; Antifungal Agents; Antineoplastic Agents; Breast Neoplasms; Cholestanetriol 26-Monooxygenase; Dexmedetomidine; Enzyme Inhibitors; Fadrozole; Female; Hypnotics and Sedatives; Mice; Mice, Inbred C57BL; Nitriles; Protein Binding; Thiazoles; Tosyl Compounds; Triazoles | 2015 |
Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression.
Topics: Animals; Apoptosis; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Oncogene Proteins; Ovarian Neoplasms; Oxazoles; RNA, Small Interfering; Thiazoles; Triazoles | 2015 |
Copolymers of acrylonitrile with quaternizable thiazole and triazole side-chain methacrylates as potent antimicrobial and hemocompatible systems.
Topics: Acrylonitrile; Anti-Infective Agents; Bacteria; Hemolysis; Humans; Kinetics; Materials Testing; Methacrylates; Microbial Sensitivity Tests; Polymers; Proton Magnetic Resonance Spectroscopy; Thiazoles; Triazoles; Yeasts | 2015 |
Dual-labeled time-resolved fluoroimmunoassay for simultaneous detection of clothianidin and diniconazole in agricultural samples.
Topics: Crops, Agricultural; Fluoroimmunoassay; Guanidines; Neonicotinoids; Pesticide Residues; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Triazoles | 2016 |
Design, Synthesis, Characterization and Antimicrobial Evaluation of Some Heterocyclic Condensed Systems with Bridgehead Nitrogen from Thiazolotriazole Class.
Topics: Anti-Bacterial Agents; Antifungal Agents; Candida; Dose-Response Relationship, Drug; Drug Design; Gram-Negative Bacteria; Gram-Positive Bacteria; Heterocyclic Compounds; Microbial Sensitivity Tests; Molecular Structure; Nitrogen; Structure-Activity Relationship; Thiazoles; Triazoles | 2015 |
Therapeutic targeting of BET protein BRD4 delays murine lupus.
Topics: Animals; Azepines; Disease Progression; DNA; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Mice; Mice, Inbred MRL lpr; Monocytes; Nerve Tissue Proteins; Nuclear Proteins; Proteinuria; Receptors, Cell Surface; Spleen; Tetrazolium Salts; Thiazoles; Transcription Factors; Triazoles | 2015 |
A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds.
Topics: Acrylamides; Acrylates; Active Transport, Cell Nucleus; Animals; Antibiotics, Antineoplastic; Biotinylation; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Exportin 1 Protein; Fatty Acids, Unsaturated; HCT116 Cells; Humans; Hydrazines; Karyopherins; Leukocytes, Mononuclear; Mice; Molecular Structure; Receptors, Cytoplasmic and Nuclear; Reproducibility of Results; Thiazoles; Triazoles | 2016 |
7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5.
Topics: Benzamides; Binding Sites; Crystallography, X-Ray; Drug Discovery; Indoles; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Protein Domains; Pyrazoles; Pyridines; Pyrimidines; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazines; Triazoles | 2016 |
Impact of HIV-1 Membrane Cholesterol on Cell-Independent Lytic Inactivation and Cellular Infectivity.
Topics: beta-Cyclodextrins; Cell Line, Tumor; Cholesterol; HIV Core Protein p24; HIV Envelope Protein gp120; HIV-1; Humans; Membrane Fluidity; Membrane Lipids; Peptides; Sulfhydryl Compounds; Thiazoles; Triazoles | 2016 |
[Development and Distribution of Drugs for NTDs: Efforts of One Pharmaceutical Company].
Topics: Animals; Antifungal Agents; Chagas Disease; Cost-Benefit Analysis; Drug Discovery; Drug Industry; Global Health; Humans; Intersectoral Collaboration; Mice; Neglected Diseases; Prodrugs; Thiazoles; Triazoles; Tropical Medicine | 2016 |
Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
Topics: Administration, Oral; Aldehyde Oxidase; Animals; Area Under Curve; Benzamides; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats, Sprague-Dawley; Risk Assessment; Substrate Specificity; Thiazoles; Triazoles | 2016 |
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Topics: Azepines; Crystallography, X-Ray; Humans; Ligands; Models, Molecular; Orexin Receptor Antagonists; Orexin Receptors; Protein Binding; Protein Conformation; Pyrrolidines; Thiazoles; Triazoles | 2016 |
IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Baculoviral IAP Repeat-Containing 3 Protein; Bone Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Survival; Cyclohexanes; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; HEK293 Cells; Humans; Inhibitor of Apoptosis Proteins; Mice, Knockout; Osteosarcoma; Phenotype; Pyrroles; Receptor-Interacting Protein Serine-Threonine Kinases; Retinoblastoma Protein; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Transfection; Triazoles; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2016 |
Synthesis of a simplified triazole analogue of pateamine A.
Topics: Antineoplastic Agents; Azides; Catalysis; Chemistry Techniques, Synthetic; Copper; Epoxy Compounds; Macrolides; Thiazoles; Triazoles | 2016 |
Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillus; Candida; Fluconazole; HEK293 Cells; Hemolysis; Heterocyclic Compounds, 2-Ring; Humans; Itraconazole; Mice; Microbial Sensitivity Tests; Reactive Oxygen Species; Structure-Activity Relationship; Thiazoles; Triazoles; Voriconazole | 2016 |
Leaching of the Neonicotinoids Thiamethoxam and Imidacloprid from Sugar Beet Seed Dressings to Subsurface Tile Drains.
Topics: Agriculture; Beta vulgaris; Bromides; Chromatography, High Pressure Liquid; Environmental Monitoring; Epoxy Compounds; Groundwater; Herbicides; Imidazoles; Insecticides; Methacrylates; Neonicotinoids; Nitro Compounds; Oxazines; Phenylacetates; Seeds; Soil; Soil Pollutants; Spectrometry, Mass, Electrospray Ionization; Strobilurins; Thiamethoxam; Thiazoles; Triazoles; Water Pollutants, Chemical | 2016 |
Synergistic mortality between a neonicotinoid insecticide and an ergosterol-biosynthesis-inhibiting fungicide in three bee species.
Topics: Animals; Bees; Brassica rapa; Fungicides, Industrial; Guanidines; Insecticides; Neonicotinoids; Thiazoles; Triazoles | 2017 |
Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Everolimus; Exportin 1 Protein; Humans; Hydrazines; Karyopherins; Lymphoma, Non-Hodgkin; Mice, Inbred ICR; Mice, SCID; Oxadiazoles; Prednisone; Protein Kinase Inhibitors; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Time Factors; TOR Serine-Threonine Kinases; Transcription Factor RelA; Triazoles; Tumor Burden; Vincristine; Xenograft Model Antitumor Assays | 2016 |
1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens.
Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Drug Discovery; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2017 |
Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; Curcumin; Databases, Genetic; Glycogen Synthase Kinase 3; Humans; Liver Neoplasms; Structure-Activity Relationship; Thiazoles; Triazoles; Urea | 2017 |
Design, synthesis, and in vitro evaluation of novel antifungal triazoles.
Topics: Antifungal Agents; Crystallography, X-Ray; Drug Design; Fungi; Microbial Sensitivity Tests; Molecular Conformation; Nitriles; Pyridines; Structure-Activity Relationship; Thiazoles; Triazoles | 2017 |
Uptake and translocation of imidacloprid, thiamethoxam and difenoconazole in rice plants.
Topics: Dioxolanes; Guanidines; Imidazoles; Neonicotinoids; Nitro Compounds; Oryza; Oxazines; Plant Leaves; Plant Roots; Soil; Soil Pollutants; Thiamethoxam; Thiazoles; Triazoles | 2017 |
Design and synthesis of 1,2,3-triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates as tubulin polymerization inhibitors.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Imidazoles; MCF-7 Cells; Molecular Docking Simulation; Molecular Structure; Polymerization; Structure-Activity Relationship; Thiazoles; Triazoles; Tubulin | 2017 |
Micturition dysfunction in four-month old ovariectomized rats: Effects of testosterone replacement.
Topics: Acetanilides; Androgens; Angiotensin II; Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intramuscular; Letrozole; Muscle, Smooth; Nitriles; Ovariectomy; Postmenopause; Rats; Rats, Sprague-Dawley; Testosterone; Thiazoles; Triazoles; Urethra; Urination Disorders | 2017 |
Lethal effects of Cr(III) alone and in combination with propiconazole and clothianidin in honey bees.
Topics: Animals; Bees; Chromium; Drug Interactions; Guanidines; Insecticides; Neonicotinoids; Pesticides; Thiazoles; Triazoles | 2018 |
Antibacterial Evaluation and Virtual Screening of New Thiazolyl-Triazole Schiff Bases as Potential DNA-Gyrase Inhibitors.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; DNA Gyrase; Molecular Docking Simulation; Protein Binding; Quantitative Structure-Activity Relationship; Schiff Bases; Thiazoles; Topoisomerase II Inhibitors; Triazoles | 2018 |
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Mice; Microbial Sensitivity Tests; Nitroimidazoles; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
In vitro antileishmanial activity of ravuconazole, a triazole antifungal drug, as a potential treatment for leishmaniasis.
Topics: Antiprotozoal Agents; Drug Repositioning; Flow Cytometry; Fluorometry; Inhibitory Concentration 50; Leishmania mexicana; Mass Spectrometry; Microscopy, Electron; Microscopy, Fluorescence; Parasitic Sensitivity Tests; Thiazoles; Triazoles | 2018 |
Combined exposure to sublethal concentrations of an insecticide and a fungicide affect feeding, ovary development and longevity in a solitary bee.
Topics: Animals; Bees; Dose-Response Relationship, Drug; Feeding Behavior; Female; Fungicides, Industrial; Guanidines; Insecticides; Longevity; Neonicotinoids; Ovary; Thiazoles; Triazoles | 2018 |
Design, Synthesis and Anticancer Activity of New Thiazole-Tetrazole or Triazole Hybrid Glycosides Targeting CDK-2 via Structure-Based Virtual Screening.
Topics: Antineoplastic Agents; Azoles; Binding Sites; Catalytic Domain; Cell Line; Cell Survival; Cyclin-Dependent Kinase 2; Drug Design; Glycosides; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Tetrazoles; Thiazoles; Triazoles | 2019 |
The chemokine CXCL1 and its receptor CXCR2 contribute to chronic stress-induced depression in mice.
Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Brain-Derived Neurotrophic Factor; Chemokine CXCL1; Depression; Fluoxetine; Glycogen Synthase Kinase 3 beta; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Phenylurea Compounds; Receptors, Interleukin-8B; Stress, Psychological; Thiazoles; Triazoles; Urea | 2019 |
Synthesis and Antibacterial Evaluation of Bis-thiazolium, Bis-imidazolium, and Bis-triazolium Derivatives.
Topics: Anti-Bacterial Agents; Cell Line; Cell Survival; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Imidazoles; Microbial Sensitivity Tests; Quaternary Ammonium Compounds; Thiazoles; Triazoles | 2019 |
Porous Microstructured Surfaces with pH-Triggered Antibacterial Properties.
Topics: Anti-Bacterial Agents; Bacterial Adhesion; Hydrogen-Ion Concentration; Microbial Viability; Polystyrenes; Porosity; Staphylococcus aureus; Static Electricity; Structure-Activity Relationship; Surface Properties; Thiazoles; Triazoles | 2019 |
High multi-azole-resistant Malassezia pachydermatis clinical isolates from canine Malassezia dermatitis.
Topics: Animals; Antifungal Agents; Azoles; Dermatomycoses; Dog Diseases; Dogs; Drug Resistance, Multiple, Fungal; Itraconazole; Japan; Malassezia; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2020 |
Fungal melanonychia caused by Candida parapsilosis successfully treated with oral fosravuconazole.
Topics: Administration, Oral; Aged; Antifungal Agents; Candida parapsilosis; Female; Hand Dermatoses; Humans; Melanosis; Onychomycosis; Prodrugs; Thiazoles; Treatment Outcome; Triazoles | 2019 |
Tinea unguium caused by terbinafine-resistant Trichophyton rubrum successfully treated with fosravuconazole.
Topics: Aged; Antifungal Agents; Drug Resistance, Fungal; Female; Hand Dermatoses; Humans; Onychomycosis; Terbinafine; Thiazoles; Tinea; Triazoles | 2019 |
Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors.
Topics: Anti-Bacterial Agents; Biofilms; Molecular Docking Simulation; Molecular Structure; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Triazoles; Virulence Factors | 2019 |
Exploring biological efficacy of coumarin clubbed thiazolo[3,2-b][1,2,4]triazoles as efficient inhibitors of urease: A biochemical and in silico approach.
Topics: Binding Sites; Catalytic Domain; Coumarins; Enzyme Inhibitors; Models, Molecular; Molecular Structure; Protein Binding; Structure-Activity Relationship; Thiazoles; Triazoles; Urease | 2020 |
Pharmacological Targeting of BET Bromodomains Inhibits Lens Fibrosis via Downregulation of MYC Expression.
Topics: Actins; Adult; Animals; Azepines; Blotting, Western; Cadherins; Cell Movement; Cell Proliferation; Down-Regulation; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibronectins; Fibrosis; Humans; Lens, Crystalline; Proteins; Proto-Oncogene Proteins c-myc; Rabbits; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Thiazoles; Transforming Growth Factor beta2; Triazoles | 2019 |
Antifungal susceptibility of dermatophyte isolates from companion animals to ravuconazole.
Topics: Animals; Antifungal Agents; Cats; Drug Resistance, Multiple, Fungal; Microbial Sensitivity Tests; Microsporum; Thiazoles; Tinea; Triazoles | 2020 |
In vitro algaecid effect of itraconazole and ravuconazole on Prototheca species.
Topics: Humans; Infections; Itraconazole; Microbial Sensitivity Tests; Prototheca; Thiazoles; Triazoles | 2020 |
In Vitro Ravuconazole Susceptibility of Anthropophilic Dermatophyte Strains Isolated from Japanese Patients.
Topics: Antifungal Agents; Arthrodermataceae; Dermatomycoses; Drug Resistance, Fungal; Humans; Itraconazole; Microbial Sensitivity Tests; Terbinafine; Thiazoles; Triazoles | 2020 |
Neuraminidase from Influenza A and B Viruses is Susceptible to the Compound 4-(4-Phenyl-1H-1,2,3-Triazol-1-yl)-2,2,6,6-Tetramethylpiperidine-1- Oxyl.
Topics: Antiviral Agents; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Influenza A virus; Influenza B virus; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Neuraminidase; Piperidines; Structure-Activity Relationship; Thiazoles; Triazoles | 2020 |
Antifungal Susceptibility of Clinical Isolates and Artificially Produced Multi-azole-resistant Strains of Cryptococcus neoformans (formerly: Cryptococcus grubii) to Ravuconazole.
Topics: Antifungal Agents; Cryptococcus neoformans; Drug Resistance, Fungal; Thiazoles; Triazoles | 2020 |
Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection.
Topics: Amlodipine; Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Topics: Antifungal Agents; Ascomycota; Fungi; Microbial Sensitivity Tests; Nitriles; Pyridines; Thiazoles; Triazoles; Voriconazole | 2020 |
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.
Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacillus subtilis; Biofilms; Candida; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Triazoles | 2021 |
Development of E1224 by leveraging a strategic partnership for the medicines creation against neglected tropical diseases.
Topics: Chagas Disease; Global Health; Neglected Diseases; Thiazoles; Triazoles; Tropical Medicine; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
In Vitro activity of ravuconazole against Candida auris and vaginal candida isolates.
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Female; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Thiazoles; Triazoles; Vagina | 2021 |
Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole.
Topics: Antifungal Agents; Drug Design; Fungi; Microbial Sensitivity Tests; Pyrimidines; Solubility; Thiazoles; Triazoles | 2021 |
Pharmacological characterization of MT-1207, a novel multitarget antihypertensive agent.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Dogs; Electrocardiography; Female; Guinea Pigs; Heart Rate; Hypertension; Male; Molecular Docking Simulation; Rabbits; Rats, Inbred SHR; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha; Stroke; Thiazoles; Triazoles; Vasodilation; Vasodilator Agents | 2021 |
Efficient Dimerization Disruption of
Topics: Antiprotozoal Agents; Cell Line; Drug Design; Humans; Leishmania infantum; NADH, NADPH Oxidoreductases; Protein Multimerization; Protein Structure, Quaternary; Structure-Activity Relationship; Thiazoles; Triazoles | 2021 |
Development of a stability-indicating assay method by HPLC-DAD and MS characterization of forced degradation products of ravuconazole.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Hydrogen Peroxide; Hydrolysis; Reproducibility of Results; Thiazoles; Triazoles | 2022 |
Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease.
Topics: Animals; Chagas Disease; Emulsions; Female; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mice; Myocytes, Cardiac; Nanostructures; Rats; Thiazoles; Triazoles; Trypanosoma cruzi | 2021 |
The hidden effects of agrochemicals on plant metabolism and root-associated microorganisms.
Topics: Agrochemicals; Crops, Agricultural; Herbicides; Italy; Microbiota; Plant Roots; Secondary Metabolism; Solanum lycopersicum; Thiazoles; Triazoles; Xenobiotics | 2021 |
Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors.
Topics: Acetamides; alpha-Glucosidases; Glycoside Hydrolase Inhibitors; Kinetics; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Thiazoles; Triazoles | 2022 |
Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.
Topics: Acetamides; Animals; Antifungal Agents; Ascomycota; Drug Discovery; Drug Evaluation, Preclinical; Fenbendazole; Madurella; Moths; Mycetoma; Neglected Diseases; Piperazines; Pyrimidines; Pyrroles; Thiazoles; Triazoles | 2022 |
Eumycetoma causative agents are inhibited in vitro by luliconazole, lanoconazole and ravuconazole.
Topics: Antifungal Agents; Humans; Imidazoles; Itraconazole; Madurella; Mycetoma; Thiazoles; Triazoles | 2022 |
Click synthesis of 1,2,3-triazoles using copper iodide nanoparticles anchored poly(sulfonamide-thiazole) modified layered double hydroxides/chitosan nanocomposite.
Topics: Chitosan; Copper; Hydroxides; Iodides; Nanocomposites; Nanoparticles; Spectroscopy, Fourier Transform Infrared; Sulfanilamide; Thiazoles; Triazoles | 2022 |
Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer.
Topics: Androgen Receptor Antagonists; Androgens; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Naphthalenes; Piperidines; Pyrrolidines; Radiation Tolerance; Receptors, Androgen; Receptors, Estrogen; Tamoxifen; Thiazoles; Triazoles | 2022 |
Design, synthesis and anti-tumor efficacy of novel phenyl thiazole/triazole derivatives as selective TrkA inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Indazoles; Molecular Structure; Morpholinos; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles; Triazoles; Tropomyosin | 2022 |
Discovery of 6-aryl-2-(3,4,5-trimethoxyphenyl)thiazole[3,2-b][1,2,4]triazoles as potent tubulin polymerization inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Structure; Polymerization; Structure-Activity Relationship; Thiazoles; Triazoles; Tubulin; Tubulin Modulators | 2023 |