An antagonist at the protease-activated receptor-1.
ChEBI ID: 83313
| Member | Definition | Class |
|---|---|---|
| vorapaxar | A carbamate ester that is the ethyl ester of [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethynyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamic acid. A protease-activated receptor-1 antagonist used (as its sulfate salt) for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation. | vorapaxar |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 18 (8.22) | 29.6817 |
| 2010's | 177 (80.82) | 24.3611 |
| 2020's | 24 (10.96) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 57 (25.33%) | 5.53% |
| Reviews | 74 (32.89%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 94 (41.78%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Proteinase-activated receptor 1 | Homo sapiens (human) | IC50 | 0.0626 | 8 | 8 |
| Proteinase-activated receptor 1 | Homo sapiens (human) | Ki | 0.0077 | 5 | 5 |