Page last updated: 2024-12-07

1,4-diethynylbenzene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,4-Diethynylbenzene is a symmetrical aromatic compound with two ethynyl groups at the para-positions. It serves as a building block for the synthesis of various conjugated polymers, dendrimers, and other advanced materials. Its rigid structure and electron-rich nature contribute to its ability to form stable pi-conjugated systems. It can be synthesized through a variety of methods, including the Sonogashira coupling reaction. 1,4-diethynylbenzene is a valuable precursor for the development of high-performance organic electronic materials due to its excellent optoelectronic properties. Its applications include organic light-emitting diodes (OLEDs), solar cells, and organic field-effect transistors (OFETs). The compound is also being investigated for its potential in medical applications, such as drug delivery and bioimaging.'

1,4-diethynylbenzene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID120463
CHEMBL ID224048
MeSH IDM0513398

Synonyms (39)

Synonym
HMS1679K02
benzene,1,4-diethynyl-
1,4-diethynyl-benzene
p-diethynylbenzene
brn 2038365
1,4-diethynylbenzene
inchi=1/c10h6/c1-3-9-5-7-10(4-2)8-6-9/h1-2,5-8
benzene, 1,4-diethynyl-
1,4-diethynylbenzene, 96%
935-14-8
CHEMBL224048
AKOS000672612
FT-0659504
D2151
A19334
30700-96-0
4-05-00-01805 (beilstein handbook reference)
benzene, p-diethynyl-
benzene, diethynyl-
AM20041423
10.14272/MVLGANVFCMOJHR-UHFFFAOYSA-N
doi:10.14272/mvlganvfcmojhr-uhfffaoysa-n
STR09668
1,4-diethynylbenzene #
1,4-bis(ethynyl)benzene
mfcd00078375
F19210
DTXSID40918397
SY039661
YSZC102
doi:10.14272/mvlganvfcmojhr-uhfffaoysa-n.1
10.14272/MVLGANVFCMOJHR-UHFFFAOYSA-N.1
p-diethynylbenzene;benzene, 1,4-diethynyl-
BCP32320
doi:10.14272/mvlganvfcmojhr-uhfffaoysa-n.2
10.14272/MVLGANVFCMOJHR-UHFFFAOYSA-N.2
1,4-diethynylbenzene, 97%
CS-W016563
EN300-1850842
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID284009Inhibition of Yersinia pestis protein tyrosine phosphatase at 100 uM2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
A two stage click-based library of protein tyrosine phosphatase inhibitors.
AID1414424Inhibition of MRP1 in human 2008/MRP1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring cell survival at 2 uM after 5 days by MTS assay relative to control2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".
AID284010Inhibition of Yersinia pestis protein tyrosine phosphatase 1B at 100 uM2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
A two stage click-based library of protein tyrosine phosphatase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.04 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.44 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]