Hypercalciuria

Excretion of abnormally high level of CALCIUM in the URINE, greater than 4 mg/kg/day.

Synonym
Hypercalciuria

Excerpt	Reference
"Hypercalciuria is believed to be a polygenic trait and is influenced significantly by diet."	( Alon, US; Srivastava, T, 2007)
"If significant hypercalciuria is found, treatment to prevent upper urinary tract calculi may be considered."	( Al-Taheini, K; Filler, G; Leonard, M, 2007)
"Hypercalciuria is a risk factor for stone disease by increasing the level of saturation of calcium oxalate and calcium phosphate in the urine and by decreasing inhibitor function."	( Smith, CL; St Peter, JV, 2007)
"Idiopathic hypercalciuria is a defect occurring in 5-10% of the general population and most commonly detected in patients with calcium kidney stones or osteoporosis."	( Gambaro, G; Soldati, L; Vezzoli, G, 2008)
"Since hypercalciuria is a common feature of idiopathic calcium oxalate (CaOx) nephrolithiasis, renal epithelial cells of stone patients are exposed to various crystals in the presence of high calcium."	( Byer, KJ; Khan, SR; Khaskhali, MH, 2009)
"Idiopathic hypercalciuria is an inherited metabolic abnormality characterised by excessive amounts of calcium excreted into the urine in patients with normal serum levels of calcium."	( Balaguer, A; Escribano, J; Feliu, A; Pagone, F; Roqué I Figuls, M, 2009)
"Hypercalciuria is a common cause for stone formation in children."	( Alon, US; Auron, A; Srivastava, T; Winston, MJ, 2009)
"Idiopathic hypercalciuria is the most important predisposing risk factor for calcium oxalate (CaOx) renal stone formation."	( Kirejczyk, JK; Konstantynowicz, J; Korzeniecka-Kozerska, A; Porowski, T; Taranta-Janusz, K; Zoch-Zwierz, W, 2009)
"Idiopathic hypercalciuria is a common disorder in children and can present with a range of clinical presentations such as hematuria, voiding dysfunction, flank pain, abdominal pain, nephrolithiasis, urinary tract infection and decreased bone mineral density."	( Schwaderer, A; Srivastava, T, 2009)
"Hypercalciuria is a risk factor for osteoporosis and nephrolithiasis."	( Blank, RD; Hansen, KE; Jones, AN; Lindstrom, MJ; Penniston, KL, 2010)
"Hypocitraturia and hypercalciuria are risk factors for calcium stone disease."	( Adeva, MM; Souto, G, 2011)
"Hypercalciuria is defined as urinary calcium excretion ≥0."	( Konrad, M; Kutilek, S; Skalova, S, 2011)
"Hypercalciuria is the most common metabolic abnormality that causes urolithiasis."	( Wróblewski, T; Wystrychowski, A, 2011)
"Idiopathic hypercalciuria is one of the most important risk factor of calcium nephrolithiasis and is classified into absorptive, resorptive, and renal leak."	( Aruga, S; Honma, Y, 2011)
"Hypercalciuria is one of the early manifestations of diabetic nephropathy."	( Akai, Y; Asai, O; Imura, A; Iwano, M; Konishi, N; Matsui, M; Nabeshima, Y; Nakatani, K; Saito, Y; Sakan, H; Samejima, K; Tanaka, T; Yamaguchi, Y; Yoshimoto, S, 2012)
"Hypercalciuria is frequent in patients with acromegaly, but it is unclear how GH/IGF-I regulate renal calcium handling."	( Azizi, M; Blanchard, A; Brailly-Tabard, S; Chanson, P; Gauci, C; Kamenický, P; Letierce, A; Lombès, M; Prié, D; Salenave, S; Souberbielle, JC, 2012)
"Hypercalciuria is the most common metabolic abnormality found in patients with calcium-containing kidney stones."	( Bushinsky, DA; Krieger, NS, 2013)
"Hypercalciuria is the most common identifiable metabolic cause of calcium kidney calculus disease."	( Heidarzadeh, A; Maleknejad, S; Moradi, B; Safaei Asl, A, 2013)
"Hypercalciuria is one of the most common causes of unexplained isolated hematuria."	( Cho, YK; Choi, IS; Choi, YE; Jung, ES; Kim, CJ; Yang, EM, 2013)
"Hypercalciuria is a common poorly understood abnormality among stone formers."	( Cook, P; Griffin, DG; Walker, V, 2014)
"Hypercalciuria is a frequent characteristic of hypertension."	( Anderson, L; Eley, S; Nichols, S; Pointer, MA; Royall, B; Waters, B; Wells, C, 2015)
"Hypercalciuria is another accompanying feature."	( Carmon, V; Farfel, Z; Halevy, R; Hanukoglu, A; Holtzman, EJ; London, S; Mayan, H; Oleinikov, K; Tenenbaum-Rakover, Y, 2015)
"Idiopathic hypercalciuria is a frequent defect in calcium kidney stone formers that is associated with high intestinal calcium absorption and osteopenia."	( Arcidiacono, T; Macrina, L; Rubinacci, A; Spotti, D; Vezzoli, G, 2016)
"Hypercalciuria is an adverse event of postsurgical hypoparathyroidism treatment that can lead to renal complications."	( Barahona, MJ; García-Pascual, L; Perea, V; Simó, R, 2017)
"Hypercalciuria is a main risk factor for kidney stone formation."	( Duan, X; Liu, Y; Wu, W; Zeng, G; Zeng, T; Zhu, W, 2018)
"Idiopathic hypercalciuria is a metabolic abnormality with various causes and developmental pathways."	( Butnaru, DV; Gerasimenko, AS; Gorbatenko, VS; Olefir, YV; Shatalova, OV; Yavorskii, AN, 2017)
"Idiopathic hypercalciuria is defined as calcium excretion greater than 220 and 300 mg/day in women and men respectively, or greater than 4 mg/kg body weight."	( Martínez, P; Pailler, M; Spivacow, FR, 2019)
"Idiopathic hypercalciuria is a heterogeneous generalized disorder caused by various defects in calcium transport and increased urinary calcium excretion."	( Fadeev, VV; Glinkina, IV; Golounina, OO; Runova, GE; Sych, YP, 2020)
"Hypercalciuria is to a large extent explained by indices of known physiological importance to 24 h U-Ca."	( Harsløf, T; Rejnmark, L; Ridder, LO; Sikjaer, T; Underbjerg, L, 2021)
"Hypercalciuria is a frequent complication in adequately treated adult TM patients."	( Aliberti, L; Ambrosio, MR; Bondanelli, M; Carnevale, A; Gagliardi, I; Gamberini, MR; Verrienti, M; Zatelli, MC; Ziggiotto, A, 2022)
"Hypercalciuria is the main risk factor for recurrent calcium urolithiasis."	( Alkouri, R; Bertocchio, JP; Castiglione, V; Cavalier, E; Daudon, M; Dousseaux, MP; Inaoui, R; Izzedine, H; Pieroni, L; Tostivint, IN, 2022)
"Hypercalciuria is common in patients with osteoporosis."	( Abdalbary, M; Chishti, E; El-Husseini, A; Faugere, MC; Mohamed, R; Nassar, MK; Parikh, T; Sawaya, BP; Sayed-Ahmed, N; Shakhashiro, M, 2023)
"Idiopathic hypercalciuria is defined as excessive urine calcium excretion in the absence of an identifiable cause."	( Tang, J; Tang, OW, 2023)

Excerpt	Reference
"Hypercalciuria has been associated to Randall's plaque formation."	( Bazin, D; Daudon, M; Letavernier, E, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	58 (9.81)	23.3326
1990's	1 (0.17)	12.5806
2000's	111 (18.78)	18.1394
2010's	337 (57.02)	28.8240
2020's	84 (14.21)	9.53

Drug	Relationship Strength	Studies	Trials
ethylene glycol	low	2	0
citric acid, anhydrous	medium	52	1
chlorine	low	3	0
glycine	low	1	0
hydrogen carbonate	low	6	0
phytic acid	medium	2	1
inositol	low	3	0
niacinamide	low	1	0
oxalic acid	low	3	0
phosphorylethanolamine	low	1	0
pyridoxal phosphate	low	1	0
pyridoxine	low	1	0
thiosulfates	medium	1	1
uric acid	medium	50	1
urea	medium	2	1
xanthine	low	1	0
alendronate	medium	22	4
bendroflumethiazide	low	1	0
celecoxib	low	1	0
chlorothiazide	low	1	0
chlorthalidone	medium	4	1
ciprofloxacin	low	1	0
deferiprone	low	2	0
deferoxamine	low	1	0
fluorouracil	medium	3	1
furosemide	medium	6	1
gentamicin	low	1	0
hydrochlorothiazide	medium	19	4
indapamide	medium	2	1
isoproterenol	low	1	0
ketoconazole	low	3	0
omeprazole	low	4	0
pantoprazole	low	1	0
potassium chloride	low	1	0
ticlopidine	low	1	0
aldosterone	low	2	0
penicillamine	low	3	0
norethandrolone	low	1	0
prednisone	low	3	0
glutamine	low	1	0
leucine	low	1	0
histidine	low	1	0
threonine	low	1	0
arginine	low	1	0
methylprednisolone	low	1	0
azacitidine	low	1	0
nandrolone	low	2	0
limestone	medium	1	1
calcium citrate	medium	5	1
potassium citrate	medium	13	2
deoxycytidine	low	2	0
durapatite	low	1	0
cyclic cmp	low	1	0
iodinated glycerol	low	1	0
cadmium	low	1	0
magnesium sulfate	medium	3	2
camptothecin	medium	1	1
calcium phosphate, dibasic, anhydrous	low	1	0
calcium phosphate, monobasic, anhydrous	low	1	0
tricalcium phosphate	medium	19	1
sodium thiosulfate	medium	1	1
chlorine	low	2	0
ammonium chloride	low	1	0
calcium oxalate	medium	56	2
colforsin	low	1	0
fura-2	low	1	0
clopidogrel	low	1	0
irinotecan	medium	1	1
capecitabine	low	2	0
triazoles	low	3	0
zoledronic acid	low	1	0
calcium phosphate, dibasic, dihydrate	low	2	0
deoxypyridinoline	low	2	0
fura-2-am	low	1	0
weddellite	low	1	0
celastrol	low	1	0
dibutyryl cyclic-3',5'-cytidine monophosphate	low	1	0
copper bis(histidinate)	low	1	0
dirhodium tetraacetate	low	1	0
cinacalcet	low	6	0
sb 203580	low	1	0
deferasirox	low	3	0
cortisone	low	4	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
carboplatin	low	1	0
indican	low	1	0
retinol	low	1	0
tacrolimus	low	1	0
cocaine	low	1	0
eicosapentaenoic acid	low	1	0
decitabine	low	1	0
sea 0400	low	1	0
thiourea	low	1	0
D-fructopyranose	low	2	0
lithium	low	2	0
cystine	low	4	0
osteoprotegerin	low	3	0
dinoprostone	low	1	0
dinoprost	low	1	0
calcitriol	medium	30	4
vitamin d 2	medium	1	1
cholecalciferol	medium	11	5
amphotericin b	low	1	0
8-epi-prostaglandin f2alpha	low	1	0
topiramate	low	2	0
deamino arginine vasopressin	low	1	0
strontium	low	2	0
phosphorus	low	16	0
25-hydroxyvitamin d 2	low	1	0
magnesium citrate	low	2	0
selenium	low	1	0
oxalates	low	18	0
s 1743	low	2	0
kb r7943	low	1	0
ym-254890	low	1	0
struvite	low	2	0
ym 244769	low	1	0
pituitrin	low	1	0
dihydrotachysterol	low	1	0
cellulose	low	2	0
interleukin-8	low	1	0
warfarin	low	1	0
epidermal growth factor	low	1	0
transforming growth factor beta	low	1	0
cyclosporine	low	4	0
levoleucovorin	medium	2	1
rifampin	low	1	0
allopurinol	low	1	0
1,24-dihydroxyvitamin d2	medium	1	1
leptin	low	1	0

Protein Targets (1,301)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
aldehyde dehydrogenase 1 family, member A1	26	0	0	26
AR protein	26	0	0	26
glucocorticoid receptor [Homo sapiens]	26	0	0	26
thyroid hormone receptor beta isoform a	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
geminin	32	0	0	32
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	3	0	3
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	5	0	5
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Guanine nucleotide-binding protein G	3	0	0	3
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	3	0	4
Farnesyl pyrophosphate synthase	0	4	0	4
Acetylcholinesterase	0	4	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	3	0	3
Farnesyl pyrophosphate synthase	0	2	0	2
interleukin 8	7	0	0	7
TDP1 protein	29	0	0	29
thyroid stimulating hormone receptor	13	0	0	13
estrogen receptor 2 (ER beta)	13	0	0	13
progesterone receptor	16	0	0	16
estrogen-related nuclear receptor alpha	26	0	0	26
estrogen nuclear receptor alpha	33	0	0	33
IDH1	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	24	0	0	24
Bloom syndrome protein isoform 1	6	0	0	6
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	17	0	0	17
ras-related protein Rab-9A	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	25	0	0	25
survival motor neuron protein isoform d	9	0	0	9
lamin isoform A-delta10	17	0	0	17
ATP-binding cassette sub-family C member 3	0	21	0	21
Multidrug resistance-associated protein 4	0	21	0	22
Polyphenol oxidase 2	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	29	0	29
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	15	0	0	15
Glutamate receptor 2	8	0	0	8
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	3	2	5
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	5
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Canalicular multispecific organic anion transporter 1	0	21	0	21
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
Chain A, Cruzipain	9	0	0	9
phosphopantetheinyl transferase	11	0	0	11
GLS protein	7	0	0	7
farnesoid X nuclear receptor	14	0	0	14
peroxisome proliferator-activated receptor delta	17	0	0	17
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	12	0	0	12
peripheral myelin protein 22	13	0	0	13
Cytochrome P450 1A2	0	4	0	5
Cytochrome P450 3A4	0	11	1	15
Cytochrome P450 2D6	0	6	0	6
Cytochrome P450 2C9	0	11	0	12
Cytochrome P450 2C19	0	9	0	10
Nuclear receptor ROR-gamma	7	0	0	7
Potassium voltage-gated channel subfamily H member 2	0	6	0	7
Aurora kinase B	0	1	1	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	18	0	0	18
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	10	0	0	10
NFKB1 protein, partial	4	0	0	4
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	7	0	0	7
chromobox protein homolog 1	16	0	0	16
flap endonuclease 1	6	0	0	6
DNA polymerase iota isoform a (long)	9	0	0	9
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	9	0	0	9
Chain A, Beta-lactamase	6	0	0	6
glp-1 receptor, partial	7	0	0	7
pregnane X receptor	7	0	0	7
RAR-related orphan receptor gamma	19	0	0	19
ATAD5 protein, partial	7	0	0	7
Fumarate hydratase	8	0	0	8
PPM1D protein	10	0	0	10
GLI family zinc finger 3	23	0	0	23
Thrombopoietin	3	0	0	3
Smad3	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	20	0	0	20
retinoid X nuclear receptor alpha	18	0	0	18
pregnane X nuclear receptor	17	0	0	17
polyprotein	8	0	0	8
67.9K protein	9	0	0	9
Parkin	2	0	0	2
peroxisome proliferator activated receptor gamma	15	0	0	15
arylsulfatase A	6	0	0	6
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
thyroid stimulating hormone receptor	8	0	0	8
activating transcription factor 6	10	0	0	10
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	3	0	0	3
cellular tumor antigen p53 isoform a	2	0	0	2
huntingtin isoform 2	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Interferon beta	20	0	0	20
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Adenosine receptor A3	0	3	0	3
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Adenosine receptor A1	0	3	0	3
D(1A) dopamine receptor	3	0	0	3
Spike glycoprotein	9	0	0	9
Multidrug and toxin extrusion protein 1	0	5	0	5
Histone-lysine N-methyltransferase EHMT2	0	2	0	2
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
acetylcholinesterase	9	0	0	9
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
DNA polymerase kappa isoform 1	8	0	0	8
cytochrome P450 3A4 isoform 1	12	0	0	12
Gamma-aminobutyric acid receptor subunit pi	12	3	0	15
Gamma-aminobutyric acid receptor subunit beta-1	12	3	0	15
Gamma-aminobutyric acid receptor subunit delta	12	3	0	15
Gamma-aminobutyric acid receptor subunit gamma-2	12	3	0	15
Gamma-aminobutyric acid receptor subunit alpha-5	12	3	0	15
Gamma-aminobutyric acid receptor subunit alpha-3	12	3	0	15
Gamma-aminobutyric acid receptor subunit gamma-1	12	3	0	15
Gamma-aminobutyric acid receptor subunit alpha-2	12	3	0	15
Gamma-aminobutyric acid receptor subunit alpha-4	12	3	0	15
Gamma-aminobutyric acid receptor subunit gamma-3	12	3	0	15
Gamma-aminobutyric acid receptor subunit alpha-6	12	3	0	15
Gamma-aminobutyric acid receptor subunit alpha-1	12	4	0	16
Gamma-aminobutyric acid receptor subunit beta-3	12	3	0	15
Gamma-aminobutyric acid receptor subunit beta-2	12	3	0	15
GABA theta subunit	12	3	0	15
Gamma-aminobutyric acid receptor subunit epsilon	12	3	0	15
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Ferritin light chain	5	0	0	5
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	11	0	0	11
Microtubule-associated protein tau	11	0	0	11
thioredoxin glutathione reductase	3	0	0	3
mitogen-activated protein kinase 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	9	0	0	9
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	1	0	1
Vitamin D3 receptor	0	2	3	9
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	1	1	2
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	1	3
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Histone H2A.x	7	0	0	7
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	7	0	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
regulator of G-protein signaling 4	9	0	0	9
EWS/FLI fusion protein	22	0	0	22
glucocerebrosidase	2	0	0	2
putative alpha-glucosidase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	4	0	0	4
relaxin receptor 1 isoform 1	2	0	0	2
Telomerase reverse transcriptase	0	2	0	2
Serine/threonine-protein kinase Chk1	0	0	2	2
Histone deacetylase 3	0	2	0	2
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	1
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	1	1	7
DNA topoisomerase 2-alpha	0	2	0	5
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Type-2 restriction enzyme HindIII	0	1	0	1
Histone deacetylase 4	0	2	0	2
Ribonuclease pancreatic	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
DNA topoisomerase 2-beta	0	0	0	1
DNA topoisomerase 1	0	1	0	2
Histone deacetylase 1	0	2	0	2
DNA topoisomerase 1	0	1	0	1
Integrase	0	2	0	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Liver carboxylesterase 1	0	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Solute carrier organic anion transporter family member 1B1	0	5	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
G	14	0	0	14
cytochrome P450 2D6	10	0	0	10
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
Inositol hexakisphosphate kinase 1	14	0	0	14
cytochrome P450 2C9, partial	14	0	0	14
L-ornithine N(5)-monooxygenase	0	1	1	2
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase isozyme L1	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Replicase polyprotein 1ab	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Ubiquitin carboxyl-terminal hydrolase isozyme L3	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	1	2
Nuclear receptor subfamily 4 group A member 1	0	0	1	1
Receptor-type tyrosine-protein phosphatase epsilon	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 6	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	1
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	0	1	0	1
Heat shock factor protein 1	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Receptor-type tyrosine-protein phosphatase eta	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	1	2
Regulator of G-protein signaling 17	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 15	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase isozyme L5	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	4	0	4
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
caspase 7, apoptosis-related cysteine protease	2	0	0	2
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Rac1 protein	0	0	1	1
caspase-3	2	0	0	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
Caspase-7	2	0	0	2
interferon gamma precursor	0	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	2
caspase-3	2	0	0	2
heat shock protein beta-1	5	0	0	5
Prostaglandin E synthase	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	1	2
Carbonic anhydrase 12	0	7	1	13
Prostaglandin G/H synthase 1	0	4	0	4
Prostaglandin G/H synthase 2	0	3	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	0	3
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 1	0	13	1	21
Carbonic anhydrase 2	0	15	2	24
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	6	1	8
Procathepsin L	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Quinolone resistance protein NorA	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	3	0	3
Beta-3 adrenergic receptor	0	3	1	4
Alpha-1B adrenergic receptor	0	4	0	4
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 1A	0	4	0	4
D(1A) dopamine receptor	0	3	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	10	1	16
Prostaglandin G/H synthase 1	0	3	0	4
Carbonic anhydrase 6	0	6	1	12
Sodium-dependent noradrenaline transporter	0	6	0	6
Adenosine receptor A1	0	1	0	2
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	8	0	8
Sodium-dependent serotonin transporter	0	3	1	5
Delta-type opioid receptor	0	4	0	4
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	4	0	4
Bifunctional epoxide hydrolase 2	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	8	2	15
Prostaglandin G/H synthase 2	0	3	2	6
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase	0	5	0	6
Alpha-1A adrenergic receptor	0	4	0	4
Carbonic anhydrase 7	0	6	1	12
Urotensin-2 receptor	0	1	0	1
Carbonic anhydrase	0	2	0	3
Ras-related protein Rab-2A	0	0	1	1
D(2) dopamine receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	3
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	4	0	4
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Sodium-dependent dopamine transporter	0	6	0	6
Prostaglandin G/H synthase 2	0	1	0	1
Mitogen-activated protein kinase 14	0	3	2	5
Carbonic anhydrase 9	0	10	1	16
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	3	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
Cyclooxygenase-2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase 15	0	4	0	5
P2Y purinoceptor 12	0	1	0	1
Carbonic anhydrase 14	0	7	1	13
Carbonic anhydrase 5B, mitochondrial	0	7	1	13
nonstructural protein 1	5	0	0	5
ORF73	0	0	1	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Carbonic anhydrase 13	0	5	0	10
Luciferase	6	0	0	6
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	3	0	3
Glycine receptor subunit alpha-1	0	0	3	3
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
PINK1	1	0	0	1
Extracellular calcium-sensing receptor	0	0	1	1
Angiotensin-converting enzyme 2	0	1	0	1
cytochrome P450 2C9 precursor	4	0	0	4
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	6	0	1	7
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	3	1	4
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
Cytochrome P450 2C8	0	4	0	4
Cytochrome P450 2B6	0	3	1	4
P2Y purinoceptor 12	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Amyloid-beta precursor protein	1	3	0	4
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
D	0	1	0	1
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	2	6
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	3	2	6
Glutamate receptor ionotropic, NMDA 2B	0	4	2	7
Glutamate receptor ionotropic, NMDA 2C	0	3	2	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	2	6
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	3	2	6
Sigma non-opioid intracellular receptor 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	2	6
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Rap guanine nucleotide exchange factor 3	4	0	0	4
ATP-dependent translocase ABCB1	0	5	0	5
5-hydroxytryptamine receptor 1A	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	0	1	1
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	2
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
endonuclease IV	4	0	0	4
dopamine D1 receptor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Glucocorticoid receptor	0	6	1	7
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4A	0	3	1	4
Lysine-specific demethylase 5A	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
apical membrane antigen 1, AMA1	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
Lysine-specific demethylase 6A	0	1	0	1
Lysine-specific demethylase 5C	0	1	0	1
Lysine-specific demethylase 2B	0	1	0	1
Deoxyhypusine hydroxylase	0	2	0	2
Lysine-specific demethylase 2A	0	1	0	1
Methylcytosine dioxygenase TET2	0	1	0	1
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Reverse transcriptase/RNaseH	0	0	1	1
Solute carrier family 22 member 2	0	2	0	4
Solute carrier family 22 member 1	0	4	0	6
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	3	2	5
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	2	4
Prostaglandin E2 receptor EP3 subtype	0	3	2	5
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	3	1	4
Solute carrier organic anion transporter family member 2A1	0	2	0	4
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	0	0	3
Solute carrier family 22 member 7	0	0	0	2
Solute carrier family 22 member 8	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier family 22 member 7	0	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))	0	1	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	2	0	2
Aromatase	0	4	0	4
Tissue factor	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Oxoeicosanoid receptor 1	0	1	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
Bile salt export pump	0	9	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	2	1	3
Thymidylate synthase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Albumin	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Cytochrome P450 2J2	0	4	0	4
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Proton-coupled amino acid transporter 1	0	2	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	1	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Hsf1 protein	0	0	1	1
GALC protein	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Alpha-2C adrenergic receptor	0	4	0	4
Multidrug and toxin extrusion protein 2	0	2	0	2
NPYLR7B	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	2
beta-2 adrenergic receptor	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-2 adrenergic receptor	0	2	2	5
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	1	0	1
Beta-1 adrenergic receptor	0	2	1	4
Beta-2 adrenergic receptor	0	0	1	1
D(4) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Beta-adrenergic receptor kinase 1	0	0	1	1
Alpha-1D adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
D(3) dopamine receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	2	2
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	0	2	2
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	2	2
Taste receptor type 2 member 13	0	0	2	2
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	2	2
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	2	2
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Alpha-2A adrenergic receptor	0	4	0	4
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Translocator protein	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Estrogen receptor	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Substance-K receptor	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
Thromboxane-A synthase	0	2	0	2
Histamine H2 receptor	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	1	4
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
ClpP	1	0	0	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Fatty acid synthase	0	4	0	4
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	2	0	2
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, Beta-arrestin 1	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Sodium/potassium/calcium exchanger 2	0	1	1	2
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Pyridoxal kinase	0	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Alpha-synuclein	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Chain A, Erk2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
tyrosine-protein kinase Yes	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Citron Rho-interacting kinase	0	1	1	2
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	1	1	2
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Mitogen-activated protein kinase 13	0	1	2	3
Mitogen-activated protein kinase 2	0	1	0	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	1	1	2
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	1	1	2
Cyclin-dependent kinase 14	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	1	2
Receptor tyrosine-protein kinase erbB-2	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Myeloperoxidase	0	1	0	1
Protein kinase C beta type	0	1	0	1
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Neutrophil elastase	0	1	0	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Serine/threonine-protein kinase pim-1	0	0	1	1
Tyrosinase	0	1	0	1
Fibroblast growth factor receptor 1	0	0	1	1
Cholesteryl ester transfer protein	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	1	1	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	1	2
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Casein kinase II subunit alpha'	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	1	2
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Protein kinase C eta type	0	1	1	2
Cyclin-dependent kinase 2	0	0	1	1
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	1	1	2
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	1	1	2
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	1	1	2
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Protein kinase C iota type	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Mitogen-activated protein kinase 14	0	1	1	2
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Casein kinase I isoform epsilon	0	1	1	2
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 12	0	1	2	3
Mitogen-activated protein kinase 10	0	2	1	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 1	0	1	1	2
Angiopoietin-1 receptor	0	1	1	2
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Protein kinase C theta type	0	1	1	2
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	1	2
Tyrosine-protein kinase BTK	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	1	1	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Serine/threonine-protein kinase D1	0	1	1	2
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	1	2	3
Serine/threonine-protein kinase STK11	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
P2X purinoceptor 7	0	1	0	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
SRSF protein kinase 1	0	0	1	1
P2X purinoceptor 7	0	1	0	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	1	1	2
BMP-2-inducible protein kinase	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase NLK	0	1	1	2
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	1	1	2
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Carbonic anhydrase	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Urease	0	2	0	3
Urease subunit alpha	0	2	0	2
D(3) dopamine receptor	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	2	0	2
Urease subunit beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	2	0	2
eyes absent homolog 2 isoform a	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Ricin	0	1	0	1
Cholinesterase	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Chain A, Guanine nucleotide-binding protein G(i) subunit alpha-1/Guanine nucleotide-binding protein G(q) subunit alpha chimeric protein	0	1	0	1
Chain B, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0	1	0	1
Guanine nucleotide-binding protein subunit alpha-11	0	1	0	1
Guanine nucleotide-binding protein G(q) subunit alpha	0	1	0	1
Guanine nucleotide-binding protein G(o) subunit alpha	0	1	0	1
Guanine nucleotide binding protein q polypeptide	0	1	0	1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (591)

Protein Targets (1,301)

Hypercalciuria

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (591)

Drugs Studied (153)

Protein Targets (1,301)