Page last updated: 2024-08-05 15:45:39
EC 3.4.21.37 (leukocyte elastase) inhibitor
An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the activity of leukocyte elastase (EC 3.4.21.37).
ChEBI ID: 64922
Members (2)
| Member | Definition | Class |
|---|---|---|
| cupressuflavone | A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-8 of the two chromene rings respectively. Isolated from Cupressus sempervirens and Juniperus occidentalis, it exhibits free radical scavenging and antielastase activities. | cupressuflavone |
| methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone | A tripeptide derived from methoxysuccinyl-Ala-Ala-Pro-Val by conversion of the terminal carboxy group to the corresponding chloromethyl ketone. | methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone |
Research
Studies (39)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 9 (23.08) | 18.7374 |
| 1990's | 12 (30.77) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 11 (28.21) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 40 (100.00%) | 84.16% |
Protein Targets (12)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.8199 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Chymotrypsin-like elastase family member 2A | Sus scrofa (pig) | IC50 | 500.0000 | 1 | 1 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 9.2900 | 1 | 1 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 9.2900 | 1 | 1 |
| Cystathionine beta-synthase | Homo sapiens (human) | IC50 | 11.5000 | 1 | 1 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 9.6000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Ki | 10.7000 | 1 | 1 |