Page last updated: 2024-08-05 15:45:39

EC 3.4.21.37 (leukocyte elastase) inhibitor

An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the activity of leukocyte elastase (EC 3.4.21.37).

ChEBI ID: 64922

Members (2)

MemberDefinitionClass
cupressuflavoneA biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-8 of the two chromene rings respectively. Isolated from Cupressus sempervirens and Juniperus occidentalis, it exhibits free radical scavenging and antielastase activities.cupressuflavone
methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketoneA tripeptide derived from methoxysuccinyl-Ala-Ala-Pro-Val by conversion of the terminal carboxy group to the corresponding chloromethyl ketone.methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone

Research

Studies (39)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19909 (23.08)18.7374
1990's12 (30.77)18.2507
2000's4 (10.26)29.6817
2010's11 (28.21)24.3611
2020's3 (7.69)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other40 (100.00%)84.16%

Protein Targets (12)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
DNA polymerase eta isoform 1Homo sapiens (human)Potency25.118911
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency79.432811
DNA polymerase kappa isoform 1Homo sapiens (human)Potency79.432811
flap endonuclease 1Homo sapiens (human)Potency63.095711
gemininHomo sapiens (human)Potency0.819911

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Beta-secretase 1Homo sapiens (human)IC5010.000011
Chymotrypsin-like elastase family member 2ASus scrofa (pig)IC50500.000011
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)IC509.290011
Cyclin-dependent-like kinase 5 Homo sapiens (human)IC509.290011
Cystathionine beta-synthaseHomo sapiens (human)IC5011.500011
Cystathionine gamma-lyaseHomo sapiens (human)IC50400.000011
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC509.600011
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)Ki10.700011