An antagonist at purinergic P2X receptors
ChEBI ID: 91081
| Member | Definition | Class |
|---|---|---|
| pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid | An arenesulfonic acid that is pyridoxal 5'-phosphate carrying an additional 2,4-disulfophenylazo substituent at position 6. | 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 126 (21.28) | 18.2507 |
| 2000's | 354 (59.80) | 29.6817 |
| 2010's | 104 (17.57) | 24.3611 |
| 2020's | 8 (1.35) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 7 (1.17%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 591 (98.83%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 22.3872 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 25.1189 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 | Rattus norvegicus (Norway rat) | IC50 | 12.0000 | 1 | 1 |
| P2X purinoceptor 1 | Mus musculus (house mouse) | IC50 | 0.0990 | 1 | 1 |
| P2X purinoceptor 1 | Rattus norvegicus (Norway rat) | IC50 | 33.1997 | 3 | 3 |
| P2X purinoceptor 2 | Homo sapiens (human) | IC50 | 2.0200 | 1 | 1 |
| P2X purinoceptor 2 | Rattus norvegicus (Norway rat) | IC50 | 1.6000 | 1 | 1 |
| P2X purinoceptor 3 | Homo sapiens (human) | IC50 | 0.2400 | 1 | 1 |
| P2X purinoceptor 3 | Rattus norvegicus (Norway rat) | IC50 | 120.1200 | 2 | 2 |
| P2X purinoceptor 4 | Homo sapiens (human) | IC50 | 16.8000 | 2 | 2 |
| P2X purinoceptor 4 | Mus musculus (house mouse) | IC50 | 21.0000 | 1 | 1 |
| P2X purinoceptor 4 | Rattus norvegicus (Norway rat) | IC50 | 251.3000 | 2 | 2 |
| P2X purinoceptor 5 | Homo sapiens (human) | IC50 | 8.4500 | 1 | 1 |
| P2X purinoceptor 6 | Rattus norvegicus (Norway rat) | IC50 | 251.0000 | 2 | 2 |
| P2X purinoceptor 7 | Homo sapiens (human) | IC50 | 1.1800 | 1 | 1 |
| P2Y purinoceptor 1 | Meleagris gallopavo (turkey) | IC50 | 16.6000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Delta-type opioid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| P2X purinoceptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.0990 | 1 | 1 |
| P2X purinoceptor 2 | Rattus norvegicus (Norway rat) | EC50 | 12.0000 | 1 | 1 |
| P2X purinoceptor 3 | Homo sapiens (human) | EC50 | 0.9700 | 2 | 2 |
| P2X purinoceptor 4 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| P2X purinoceptor 4 | Rattus norvegicus (Norway rat) | EC50 | 10.0000 | 1 | 1 |
| P2X purinoceptor 5 | Rattus norvegicus (Norway rat) | EC50 | 2.6000 | 1 | 1 |
| P2X purinoceptor 6 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| P2X purinoceptor 7 | Rattus norvegicus (Norway rat) | EC50 | 62.0000 | 1 | 1 |
| P2Y purinoceptor 1 | Homo sapiens (human) | EC50 | 9.6000 | 2 | 2 |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| P2Y purinoceptor 2 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| P2Y purinoceptor 4 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |