Compounds > triazoles
Page last updated: 2024-08-24

triazoles and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine

triazoles has been researched along with 1-hexadecyl-2-acetyl-glycero-3-phosphocholine in 717 studies

Research

Studies (717)

TimeframeStudies, this research(%)All Research%
pre-199056 (7.81)18.7374
1990's561 (78.24)18.2507
2000's81 (11.30)29.6817
2010's18 (2.51)24.3611
2020's1 (0.14)2.80

Authors

AuthorsStudies
Giessler, C; Mentz, G; Mentz, P; Mest, HJ1
Porsius, AJ; Vleeming, W; Wemer, J1
Kurachi, Y; McGregor, CG; Mutoh, H; Shimizu, T; Sugimoto, T; Tsuchimochi, H1
Black, SC; Driscoll, EM; Lucchesi, BR1
Braquet, P; Sagach, VF; Zhukova, AV1
Andries, R; Bourgain, RH; Braquet, P; Esanu, A1
Bonhomme, B; Braquet, P; Doly, M; Droy-Lefaix, MT; Millerin, M1
Ono, S; Voelkel, NF2
Esser, KM; Feuerstein, G; Hillegas, LM; Rabinovici, R; Renz, JF; Sofronski, MD; Vernick, J1
Hakkert, BC; Hart, MH; Kuijpers, TW; Roos, D1
Andrews, MJ; Cunningham, FM; Foster, AP; Lees, P2
Böhm, M; Erdmann, E; La Rosée, K; Schwinger, RH1
Bates, EJ; Ferrante, A; Kowanko, IC1
de Lima, WT; Jancar, S; Sirois, P1
Braquet, P; Filep, JG; Földes-Filep, E; Hermán, F; Schneider, F1
Turner, NC; Wood, LJ1
Auclair, E; Braquet, P; Broquet, C; Chabrier, PE; Domingo, MT; Piro, F1
Carolan, EJ; Casale, TB2
Bito, H; Honda, Z; Izumi, T; Nakamura, M; Shimizu, T1
Donigi-Gale, D; Edwards, R; Norman, KE; Rossi, AG; Shoupe, TS; Williams, TJ1
Ambruso, DR; Silliman, CC; Thurman, GW1
Rui, YC; Shen, YA; Sun, DX; Zeng, GQ; Zhu, J1
Müller, S; Nigam, S1
Zhang, JN1
Blank, B; Kempe, ER1
Bienvenu, K; Granger, DN; Russell, J1
Bozza, PT; Castro-Faria-Neto, HC; Cordeiro, RS; Lima, MC; Martins, MA; Silva, AR; Silva, PM; Vargaftig, BB1
Asakura, K; Kataura, A; Kojima, T; Narita, S; Saitoh, H; Shirasaki, H1
Bahr, T; Grupe, R; Labes, D; Lohde, C1
Fisher, RA; Hines, KL1
Barrachina, MD; Esplugues, JV; Martinez-Cuesta, MA; Piqué, JM; Whittle, BJ1
Iwahisa, Y; Okamoto, H; Terasawa, M1
Befus, AD; Davison, JS; Mathison, R1
Ono, S; Voelkel, NF; Westcott, JY1
Benyó, Z; Csáki, C; Kovách, AG; Szabó, C1
Dodam, JR; Johnson, LW; Kruse-Elliott, KT; Olson, NC1
Faden, AI; Tzendzalian, PA1
Heuer, HO; Muacevic, G1
Armstrong, ML; Densen, P; Heistad, DD; Lopez, JA; Mügge, A; Padgett, RC; Piegors, DJ1
Levine, BA; McCollum, MO; Olson, MS; Zhou, W2
Chao, W; Levine, BA; Olson, MS; Zhou, W1
Bewtra, AK; Hopp, RJ; Miyagawa, H; Nabe, M; Okada, C; Townley, G1
Shankar, G; Stern, PH1
Creutzfeldt, W; Fayyazzi, A; Leonhardt, U; Seidensticker, F; Söling, HD; Stöckmann, F1
Caramelo, C; Egido, J; Escanero, J; Gómez-Garre, D; González, E; Guerra, M; López-Farré, A; Riesco, A1
Chakrabarty, S; Flores, NA; Fluck, DS; Sheridan, DJ1
Chang, SW; Chen, CR; Voelkel, NF2
Javors, MA; Olson, MS; Zhou, W1
Leong, LL; Papadimitriou, JM; Stephens, CJ; Sturm, MJ; Taylor, RR1
Krantz, S; Lefer, AM; Ma, XL; Weyrich, AS1
Binnaka, T; Fujimura, K; Inoue, K; Kitagawa, S; Kubota, Y; Mizuno, T; Tani, K; Yamaguchi, T1
Bergmann, R; Brecht, HM; Gokel, M; Hammer, C; Saumweber, DM; Zellner, C1
Leong, LL; Stephens, CJ; Sturm, MJ; Taylor, RR1
Alison, MR; Antoniw, JW; Garvey, B; Maseri, A; Tippins, JR1
Bates, EJ; Ferrante, A; Harvey, DP1
Blom, M; Koenderman, L; Kok, PT; Roos, D; Tool, AT; Verhoeven, AJ1
Chand, N; Diamantis, W; Nolan, K; Sofia, RD1
Cardillo, R; DiMuzio, J; Post, TJ; Raible, DG; Schulman, ES1
Abraham, WM; Ahmed, T; Mansour, E1
Lewis, SA; Raeburn, D; Underwood, SL1
Faden, AI; Halt, P1
Kawahara, T; Machida, Y; Miyazawa, S; Okano, K; Yamatsu, I1
Braillon, A; Cailmail, S; Champigneulle, B; Gaudin, C; Kleber, G; Lebrec, D1
Di Braccio, M; Grossi, GC; Leoncini, G; Maresca, M; Roma, G1
Amorim, CZ; Cordeiro, RS; Martins, MA; Vargaftig, BB1
Ahmed, A; Smith, SK1
Braquet, C; Köpernik, W; Mest, HJ; Rein, T; Riedel, A1
McIntyre, TM; Prescott, SM; Smiley, PL; Stremler, KE; Zimmerman, GA1
Adamus, WS; Birke, FW; Brecht, HM; Heuer, HO; Kempe, ER1
Coëffier, E; Joseph, D; Vargaftig, BB1
Caplan, MS; Hsueh, W; Kelly, A; Zhang, C1
Cavero, I; Floch, A; Sedivy, P; Tahraoui, L1
Lim, WH; Stewart, AG1
Balsinde, J; Mollinedo, F1
Bernat, A; Gigo, V; Herbert, JM; Lale, A; LaPlace, MC; Le Fur, G; Lespy, L; Maffrand, JP; Savi, P; Valette, G1
Burghardt, C; Crowley, HJ; Janero, DR; O'Donnell, M; Selig, WM; Welton, AF; Yaremko, B1
Corfield, DR; Webber, SE; Widdicombe, JG1
Bito, H; Honda, Z; Izumi, T; Matsumoto, T; Minami, M; Mutoh, H; Nakamura, M; Noma, M; Sakanaka, C; Seyama, Y1
Durán, WN; Tomeo, AC1
Busse, WW; Sedgwick, JB; Vrtis, RR; Zoratti, EM1
Gaa, ST; Kohout, TA; Lederer, WJ; Massey, CV; Rogers, TB1
Mayeux, PR; Shah, SV; Ueda, N; Walker, PD1
Hofmann, B; Kertscher, HP; Lorenz, A; Ostermann, G1
Hirafuji, M; Shinoda, H3
Goldie, RG; Pedersen, KE; Rigby, PJ1
Grigoriadis, G; Stewart, AG2
Chan, WP; Levy, JV1
Hu, WM; Man, RY1
Filep, JG; Fournier, A; Rousseau, A; Sirois, MG; Sirois, P1
Harris, T; Stewart, AG1
Casals-Stenzel, J3
Hara, H; Mase, T; Murase, K; Nagaoka, H; Saito, M; Tomioka, K; Yamada, T1
Ammit, AJ; O'Neill, C2
Amorim, CZ; Cordeiro, RS; Henriques, MG; Vargaftig, BB; Weg, VB1
Brain, SD; Buckley, TL; Collins, PD; Williams, TJ1
Cordeiro, RS; Watson, ML; Weg, VB; Williams, TJ1
O'Neill, C; Ryan, JP; Spinks, NR1
Chand, N; Diamantis, W; Nolan, K; Pillar, J; Sofia, RD1
Gilfillan, AM; Hope, WC; Patel, BJ; Welton, AF; Wiggan, GA1
Ahmad, Z; Baumann, G; Berdel, WE; Felix, SB; Hashemi, T; Niemczyk, M3
Chao, W; Levine, BA; Olson, MS; Zhou, WG1
Eliakim, R; Karmeli, F; Okon, E; Rachmilewitz, D1
Anderson, BO; Banerjee, A; Bensard, DD; Harken, AH; Nelson, DW; Pitman, JM; Poggetti, RS; Shanley, PF; Whitman, GJ1
Honda, Z; Kurokawa, K; Shimizu, T; Takano, T; Uchida, S; Watanabe, T1
Ammit, AJ; Fleming, S; Korth, R; O'Neill, C; Wells, X1
Beck, T; Bielenberg, GW; Wagener, G1
Borst, HG; Fieguth, HG; Haverich, A; Hirt, SW; Jurmann, M; Wahlers, T1
Imura, Y; Kawamura, M; Nishikawa, K; Takatani, M; Terashita, Z; Tsushima, S1
Catto-Smith, AG; Gall, DG; MacNaughton, WK1
Horvath, CJ; Kaplan, JE; Malik, AB1
Brandt, R; Kanowski, U; Kempfert, C; Oddoy, A; Siewert, B1
Benveniste, J; Bidault, J; Jurgens, P; Leyravaud, S; Ninio, E1
Katayama, K; Katayama, S; Sakuma, Y; Shirato, M; Tsunoda, H; Yamatsu, I1
Peskar, BA; Pritze, S; Simmet, T2
Gall, DG; MacNaughton, WK1
Franklin, R; Gelfand, EW; Mazer, BD; Sawami, H1
Buckman, D; Iverson, L; Srivastava, A; Thomas, TK; Weis, W; Will, PC; Wilson, C1
Bureau, M; Dry, J; Lefort, J; Vargaftig, BB; Vincent, D1
Heuer, HO4
Klee, A; Schmid-Schönbein, GW; Seiffge, D1
Harada, K; Katayama, K; Katayama, S; Muramoto, K; Sakuma, Y; Tsunoda, H1
Kulikov, VI; Muzia, GI1
Korth, R; Middeke, M1
Becker, K; Förster, W; Lueddeckens, G; Rappold, R1
Asano, O; Clark, RS; Kawahara, T; Miyamoto, M; Miyazawa, S; Muramoto, K; Okano, K; Sakuma, Y; Shimomura, N; Yoshimura, H1
Katayama, K; Katayama, S; Nagaoka, J; Obaishi, H; Ono, H; Sakuma, Y; Shirato, M; Tsunoda, H1
Herbert, JM; Lespy, L; Maffrand, JP1
Birke, FW; Ensinger, HA1
Barnes, PJ; Chung, KF1
Braquet, P; Ferreira, MG; Fonteles, MC1
Caplan, MS; Hsueh, W; Sun, XM2
Darius, H; Heuer, HO; Lohmann, HF; Meyer, J; Schierenberg, M; Treese, N1
Braquet, P; Esanu, A; Hosford, D; Laurent, JP; Martin, C; Pommier, J; Rolland, A1
Imura, Y; Maezaki, N; Nishikawa, K; Takatani, M; Terashita, Z; Tsushima, S1
Bozza, PT; Castro-Faria-Neto, HC; Cordeiro, RS; Correia-Da-Silva, AC; Martins, MA; Morhy, L; Sousa, MV1
Baba, I; Hayashi, Y; Katagiri, Y; Suzuki, H; Tanoue, K; Yamazaki, H1
Feuerstein, G; Gleason, MM; Gu, JL; Hallenbeck, J; Lysko, PG; Yue, TL1
Terasawa, M1
Braquet, P; Esanu, A; Hosford, D; Koltai, M; Tosaki, A1
Harada, K; Katayama, K; Machida, Y; Obaishi, H; Sakuma, Y; Shimomura, N; Shirato, M; Tsunoda, H; Yamada, K; Yamatsu, I1
Calne, RY; Collier, DG; DaCosta, M; Friend, PJ; Luddington, R; Metcalfe, SM; Pollard, SG; Watson, CJ1
Heuer, HO; Keller, B; Urich, K1
Harvey, W; Hopps, RM; Murphy, CT; Wasil, M1
Fenton, J; Gudewicz, PW; Kaplan, JE; Moon, DG; van der Zee, H1
Keser, C; Kohl, J; Machleidt, W; Schweiberer, L; Siebeck, M; Spannagl, M; Weipert, J1
Balmes, J; Fine, J; Gordon, T; Sheppard, D1
Bradley, LM; Czaja, JF; Goldstein, RE; Stambouly, JJ1
Gundel, RH; Letts, LG; Wegner, CD1
Burrows, LJ; Lindley, ID; Piper, PJ; Westwick, J1
Ban, C; Hasegawa, M; Ihara, Y; Inamori, K; Itoh, H; Li, XM; Mori, T; Okagaki, A; Sagawa, N1
Abendschein, DR; Bergmann, SR; Haskel, EJ; Torr, SR; VonVoigtlander, PF1
Bonne, C; Meynier, F; Muller, A1
Goldie, RG; Paterson, JW; Pedersen, KE; Rigby, PJ1
Mikashima, H; Muramoto, Y; Setoguchi, M; Tahara, T; Takehara, S; Terasawa, M1
Giers, G; Janzarik, H; Kempe, ER; Mueller-Eckhardt, C2
Bazan, NG; Braquet, PG; Emoto, SE; Esanu, A; Fitzpatrick, JH; Gilboe, DD; Kintner, D1
Dive, C; Watson, JV; Workman, P1
Donaldson, J; Lohmeyer, M; Workman, P1
Bergmann, R; Brecht, HM; Gokel, M; Hammer, C; Saumweber, DM1
Abbas, MK; Casale, TB1
Crowley, H; Flynn, T; Maresca, C; Mason, C; O'Donnell, M; Walser, A; Yaremko, B1
Heuer, H; Meade, CJ1
Neugarten, J; Schlondorff, D; Yoo, J1
Crowley, H; Flynn, T; Maresca, C; Mason, C; O'Donnell, M; Walser, A1
Horie, M; Mase, T; Nagaoka, H; Sakurai, Y; Tomioka, K; Yamada, T1
Hirasawa, N; Mue, S; Ohuchi, K; Omata, M; Tsurufuji, S; Watanabe, M; Yagi, M1
Barnes, PJ; Chung, KF; Lötvall, JO; Tokuyama, K1
Feuerstein, G; Gleason, MM; Hallenbeck, J; Yue, TL1
Braquet, P; Friedrich, G; Giessler, J; Hirschelmann, R; Madi, S1
Braquet, P; Esanu, A1
Arima, M; Makino, S; Sagara, H; Terashi, Y; Yukawa, T1
Barnes, PJ; Challiss, RA; Chilvers, ER; Giembycz, MA; Kroegel, C1
Barnes, PJ; Chung, KF; Griffith, S; Hayes, JP; Ridge, SM1
Barnes, PJ; Belvisi, MG; Stretton, CD1
Barnes, PJ; Dijk, S; Rogers, DF1
Clark, R; Harada, K; Horie, T; Katayama, S; Miyazawa, S; Muramoto, K; Okano, K; Sakuma, Y; Shimomura, N; Tsunoda, H2
Harada, K; Katayama, S; Machida, Y; Miyazawa, S; Obaishi, H; Okano, K; Sakuma, Y; Shirato, M; Tsunoda, H; Yamada, K1
Cordeiro, RS; e Silva, PM; Martins, MA; Pasquale, CP; Vargaftig, BB1
Aratani, H; Setoguchi, M; Tahara, T; Terasawa, M1
Evans, RW; Kochanek, PM; Magargee, MJ; Melick, JA; Nemoto, EM; Schoettle, RJ2
Egan, RW; Fernandez, X; Gulbenkian, AR; Kreutner, W; Kung, T; Minnicozzi, M; Watnick, AS1
Heuer, HO; Letts, G; Meade, CJ1
Hauser, A; Heinroth-Hoffmann, I; Mest, HJ1
Geissler, FT; Henderson, WR; Kuzan, FB1
Aepfelbacher, M; Korth, R; Weber, PC1
Barnes, PJ; Giembycz, MA; Kroegel, C1
Barnes, PJ; Chanez, P; Dent, G; Sybrecht, GW; Ukena, D1
Granger, DN; Ibbotson, G; Kubes, P; Russell, J; Wallace, JL1
Bloom, JW; Gomez, J; Halonen, M; Yamamura, HI1
Zhang, F1
Blair, IA; Christman, BW; Lefferts, PL; Snapper, JR1
Beckerman, RC; Bellan, JA; Braquet, P; Dyson, MC; Kadowitz, PJ; McNamara, DB; Minkes, RK; Wegmann, MJ1
Collins, PD; Tannière-Zeller, M; Williams, FM; Williams, TJ1
Esser, KM; Farhat, M; Feuerstein, G; Rabinovici, R; Slivjak, M; Smith, EF; Yue, TL1
Feuerstein, G; Frerichs, KU; Hallenbeck, JM; Lindsberg, PJ; Yue, TL1
Conklyn, M; Conyers, G; Cramer, E; Milks, L; Showell, H1
Casals-Stenzel, J; Heuer, HO1
Brendel, W; Conzen, PF; Gutmann, R; Habazettl, H; Hobbhahn, J; Peter, K; Vollmar, B; Yekebas, E1
Conklyn, M; Showell, HJ; Watson, JW1
Durham, SK; Selig, WM; Tocker, JE; Welton, AF1
Barnes, PJ; Evans, TW; McCormack, DG2
Bazill, GW; Dexter, TM1
Jones, SB; Qi, M1
Charlier, A; Keyeux, A; Pouleur, H; Raigoso, J; Schröder, E; Van Mechelen, H1
Barton, PA; Mandel, DM; Matrosic, K; Warren, JS1
Casals-Stenzel, J; Heuer, HO; Muacevic, G; Weber, KH1
Befus, AD; Davison, JS; Mathison, R; Rimmer, C; Wallace, JL1
Gerring, EL; King, JN1
Conroy, DM; Piper, PJ; Samhoun, MN1
Chang, SW; Fernyak, S; Voelkel, NF1
Armour, CL; Black, JL; Johnson, PR1
Finn, CA; Milligan, SR1
Barnes, PJ; Chung, KF; Cole, PJ; Kroegel, C; Read, RC; Rutman, A; Wilson, R; Yukawa, T1
Fenton, JW; Kaplan, JE; Krasodomski, JA; Moon, DG; Morton, KD; van der Zee, H1
Handley, DA; Havill, AM; Van Valen, RG1
Adamus, WS; Heuer, HO; Meade, CJ; Schilling, JC1
Cordeiro, RS; Fernandes, PD; Henriques, MG; Martins, MA; Silva, PM; Vargaftig, BB; Weg, VB1
Håkansson, L; Venge, P1
Burton, DL; Cotter, JL; Sturm, MJ; Vandongen, R1
Farhat, M; Feuerstein, G; Rabinovici, R; Yue, TL1
Bassot, S; Chignard, M; Ferrer-Lopez, P; Laurent, P; Renesto, P; Schattner, M1
Adi, S; Feingold, KR; Fiers, W; Grunfeld, C; Moser, A; Soued, M1
Feuerstein, GZ; Frerichs, KU; Hallenbeck, JM; Lindsberg, PJ1
Erjefält, I; O'Donnell, SR; Persson, CG1
Hogaboam, CM; McKnight, GW; Wallace, JL1
Desquand, S; Dumarey, C; Lefort, J; Vargaftig, BB1
Halonen, M; Lohman, I1
Calne, RY; Da Costa, M; Metcalfe, S1
Bergmann, R; Brecht, HM; Hammer, C; Saumweber, DM1
Farhat, M; Feuerstein, G; Perera, PY; Rabinovici, R; Vogel, SN; Yue, TL1
Feuerstein, G; Rabinovici, R; Rudolph, AS; Yue, TL1
Lefort, J; Pretolani, M; Vargaftig, BB1
Dubbin, PN; Dusting, GJ; Harris, T; Stewart, AG1
Piper, PJ; Yaacob, HB1
Barnes, P; Chanez, P; Dent, G; Sybrecht, G; Ukena, D1
Heuer, H; Weber, KH1
Griffin, K; Hong, T; Levy, JV1
Barnes, PJ; Chung, KF; Dent, G; Kroegel, C; Venge, P; Yukawa, T1
Barnes, PJ; Dent, G; Krogel, C; Sybrecht, G; Ukena, D; Yukawa, T1
Braquet, P; Cluzel, J; Doly, M; Meyniel, G; Thierry, A1
Barnes, PJ; Kroegel, C; Westwick, J; Yukawa, T1
Phillips, WA; Stewart, AG1
Barnes, PJ; Dent, G; Sybrecht, GW; Ukena, D1
Benveniste, J; Bidault, J; Delautier, D; Hirafuji, M; Keraly, CL; Korth, R1
Bralet, J; Rochette, L; Tannière-Zeller, M1
Bienenstock, J; Hanglow, AC; Perdue, MH1
Koenderman, L; Roos, D; Tool, AT; Verhoeven, AJ1
Braquet, P; Domingo, MT; Etienne, A; Martins, MA; Soulard, C1
Casals-Stenzel, J; Heuer, H2
Imura, Y; Iwasaki, K; Nishikawa, K; Shibouta, Y; Terashita, Z1
Bitterman, H; Lefer, AM; Stahl, GL1
Abraham, WM; Garrido, R; Stevenson, JS1
Adamus, WS; Heuer, H; Meade, CJ1
Petty, AC; Scrutton, MC1
Benveniste, J; Brink, C; Brunelleschi, S; Fantozzi, R; Giotti, A; Ledda, F; Renzi, D1
Antoniw, JW; Izumi, T; Piper, PJ; Stanton, AW1
Dixon, EJ; Page, CP; Robertson, DN; Wilsoncroft, P1
Abraham, WM; Sielczak, MW; Solèr, M1
Heuer, H1
Bahrami, S; Paul, E; Redl, H; Schiesser, A; Schlag, G; Thurnher, M; Vogl, C1
Fauler, J; Frölich, JC; Sielhorst, G1
Hoffmann, IH; Mentz, G; Mentz, P; Mest, HJ; Meyer, E; Riedel, A; Sperling, J; Tschorn, W1
Chang, SW; Kuo, G; Ohara, N; Voelkel, NF1
Barnes, PJ; Chung, KF; Evans, P; Fukuda, T; Kroegel, C; Yukawa, T1
Dusting, GJ; Stewart, AG1
Adamus, WS; Lohmann, HF; Meade, CJ1
Adamus, WS; Brecht, HM; Heuer, H; Meade, CJ1
Barnes, PJ; Chung, KF; Kroegel, C; Pleass, R; Westwick, J; Yukawa, T1
Bozza, PT; Cordeiro, RS; Dias, PM; Faria Neto, HC; Lima, MC; Martins, MA; Silva, PM; Vargaftig, BB1
Del Monte, M; Subissi, A1
Fortes, ZB; Garcia-Leme, J; Lagente, V; Vargaftig, BB2
Adamus, WS; Brecht, HM; Frey, G; Heuer, H; Meade, CJ1
Griffin, KJ; Levy, JV1
Barnes, PJ; Birke, FW; Dent, G; Robaut, C; Sybrecht, GW; Ukena, D1
Aursudkij, B; Barnes, PJ; Chung, KF; Dent, G; Evans, TW; Rogers, DF1
Barnes, PJ; Chanez, P; Chung, KF; Dent, G; Kroegel, C; Yukawa, T1
Brambilla, A; Ghiorzi, A; Giachetti, A1
Casals-Stenzel, J; Muacevic, G; Weber, KH1
Lefort, J; Malanchère, E; Pretolani, M; Vargaftig, BB1
Casals-Stenzel, J; Franke, J; Friedrich, T; Lichey, J1
Maruyama, Y; Mikashima, H; Tahara, T; Terasawa, M1
Abacioğlu, N; Cakici, I; Ersoy, S; Kanzik, I; Mataraci, N; Tunçtan, B1
Exner, B; Leonhardt, U; Nebendahl, K; Ritzel, U; Schrock, E; Stöckmann, F1
Becker, K; Brodde, OE; Giessler, C; Heinroth-Hoffmann, I; Pönicke, K1
Bremer, C; Lang, H; Oldhafer, KJ; Pichlmayr, R; Schüttler, W; Spiegel, HU1
Battaglia, E; Bussolino, F; Camussi, G; Emanuelli, G; Lupia, E; Montrucchio, G; Passerini, G1
Chandel, B; Deshpande, Y; Kaminski, DL; Longo, WE; Niehoff, M; Polities, G; Robinson, S; Vernava, AM1
Greenlees, C; Medhurst, AD; Parsons, AA; Smith, SJ1
Bury, T; Corhay, JL; Louis, R; Radermecker, MF1
Biancone, L; Camussi, G; Duc, TM; Montrucchio, G; Ruikun, C; Silvestro, L; Sommer, F1
Bordet, JC; Chomarat, P; Defrance, T; McGregor, JL; Miossec, P; Murphy, JF; Rissoan, MC; Wyler, B1
Abdo, EE; Bonizzia, A; Coelho, AM; Jancar, S; Kwasniewski, FH; Machado, MC; Sampietre, SN1
Duncker, HP; Heller, A; Koch, T; Neuhof, H; Schaible, R; van Ackern, K1
Anderson, DC; Aw, TY; Granger, DN; Grisham, MB; Kurtel, H; Liao, L; Miyasaka, M; Tso, P1
Aglietta, M; Arese, M; Barra, L; Benelli, R; Bussolino, F; Ghigo, D; Montrucchio, G; Primo, L; Rola-Pleszczynski, MR; Sanavio, F1
Haruta, Y; Hozawa, S; Ishioka, S; Yamakido, M1
Dohi, T; Miyasako, T; Morita, K; Suemitsu, T; Uchiyama, Y1
Anderson, WP; Thomas, CJ; Woods, RL1
Qin, X; Yu, P; Yuan, J1
Bado, A; Braquet, P; Laigneau, JP; Lewin, MJ; Moizo, L; Sobhani, I; Tarrade, T1
Appleyard, CB; Hillier, K1
Lohmeyer, M; Workman, P1
Langer, JC; Liebman, SM; Monk, PK; Pelletier, GJ1
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Caplan, M; Chang, H; Gonzalez-Crussi, F; Hsueh, W; Qu, XW; Tan, XD1
Howard, KM; Olson, MS1
Ibe, BO; Raj, JU; Sander, FC1
Boichot, E; Braquet, P; Carre, C; Guinot, P; Lagente, V; Mencia-Huerta, JM1
Ahmed, A; Ahmed, Z; Dearn, S; Eggo, MC; Lewis, A; Rahman, M1
Palmer, C; Roberts, RL; Viswanath, M1
Komatsu, H; Kusuhara, H; Matsuyuki, H; Sugahara, K; Terasawa, M; Yamaguchi, S1
Cho, HG; Cho, O; Hybertson, BM; Lee, YM; Repine, AJ; Repine, JE; Terada, LS1
Sun, GY; Wang, JH1
Choi, IW; Choi, JH; Chung, WJ; Han, SJ; Han, SS; IM, SY; Jang, KY; Lee, DG; Lee, HB; Lee, HK; Park, KH1
Aksungar, FB; Bilsel, S; Bozkurt, A; Cetinel, U; Coşkun, T; Granger, DN; Haklar, G; Kurtel, H; Oktar, BK; Yegen, BC; Yüksel, M1
Barreiro, EJ; de Miranda, AL; Fraga, AG; Fraga, CA; Rodrigues, CR1
Dohi, T; Kitayama, S; Kurihara, H; Mizuno, N; Morita, K; Shibata, K; Shinohara, H; Yoshino, H1
Biancone, L; Bussolati, B; Camussi, G; Cassoni, P; Montrucchio, G; Rola-Pleszczynski, M; Russo, S1
Alloatti, G; Camussi, G; Mariano, F; Penna, C1
Aizawa, H; Fukuyama, S; Hara, N; Inoue, H; Komori, M; Koto, H; Matsumoto, K1
Arese, M; Biancone, L; Bussolino, F; Camussi, G; Del Sorbo, L; Giraudo, E; Tizzani, M1
Balogh, I; Kecskeméti, V1
Fujimura, A; Kawaguchi, A; Sugimoto, K1
Ida, S; Ishizuka, S; Kamanaka, M; Nakayama, K; Sasaki, H; Sekizawa, K; Suzuki, T; Yamaya, M1
Li, J; Tu, W; Zhu, W1
Dutra, PM; Lopes, AH; Pereira, AF; Rosa , MS; Vieira, RB1
Barks, JD; Eun, BL; Liu, XH1
Chang, PY; Chen, CH; Henry, PD; Jiang, T; Lee, YT; Lu, SC; Luo, S1
Chen, Y; Huang, H; Liu, Y1
Fonteles, MC; Havt, A; Monteiro, HS1
Li, J; Li, N; Tu, W; Zhu, W1
Ichinowatari, G; Ohuchi, K; Tanimoto, A; Tsuyuki, K; Yaginuma, H; Yamada, M2
Makiyama, Y; Mitsui, Y; Tanaka, Y1
Evanson, OA; McClenahan, DJ; Weiss, DJ1
Bianchi, L; Cellai, C; Della Malva, N; Laurenzana, A; Paoletti, F; Vannucchi, AM1
Carlson, SL; Hostettler, ME1
Carlson, SL; Hostettler, ME; Knapp, PE1
Benito, E; Bosch, MA1
Evanson, OA; Weiss, DJ1
Gokorsch, S; Grimminger, F; Krüll, M; Lohmeyer, J; Mayer, K; Merfels, M; Muhly-Reinholz, M; Rosseau, S; Schwarzer, N; Seeger, W; Suttorp, N1
Greischel, A; Leusch, A; Müller, G; Roth, W; Sauer, A; Volz, A; Wagner, A1
Boyle, HL; Jauchem, JR; Ryan, KL; Tehrany, MR1
Choi, EK; Choi, IW; Choi, JH; Han, SJ; Im, SY; Ko, HM; Lee, HK; Lee, HS; Seo, KH1
Magnusson, JE; Teather, LA; Wurtman, RJ1
Grandel, U; Grimminger, F; Hattar, K; Hoffmann, S; Mayer, K; Schenkel, A; Seeger, W; Sibelius, U1
Cheung, LY; Childs, EW; Hunter, FA; Smalley, DM; Udobi, KF; Wood, JG1
Cho, HG; Hybertson, BM; Lee, YM; Repine, JE1
Rasheed, H; Saeed, SA1
Dow, CS; Falcioni, G; Gabbianelli, R; Swoboda, B; Vince, FP1
Biffl, WL; Carnaggio, R; Gonzalez, RJ; Moore, EE; Offner, PJ; Silliman, CC; West, KE1
Casillan, AJ; Gonzalez, NC; Johnson, JS; Steiner, DR; Wood, JG1
Kato, M; Kurose, T; Miyaji, S; Oda, T1
Bussolati, B; Camussi, G; Deambrosis, I; Mariano, F; Russo, S1
Alloatti, G; Altruda, F; Azzolino, O; Barberis, L; Bedendi, I; Bosco, O; Del Sorbo, L; Hirsch, E; Levi, R; Malan, D; Marcantoni, A; Montrucchio, G; Penna, C; Wymann, M1
Rhee, CK1
Jung, TT; Park, SK; Rhee, CK1
Al-Salti, W; Booth, IW; Coney, AM; Ewer, AK; Marshall, JM; Ramani, P1
John, EO; Jung, TT; Park, SK; Park, YS; Rhee, CK1
Burgos, RA; Folch, H; Hancke, JL; Hermosilla, R; Hidalgo, MA; Matthei, SM1
Chlopicki, S; Jakubowski, A; Olszanecki, R1
Imoto, K; Kato, M; Miyaji, S; Miyake, H; Nakamura, M; Oda, T1
Bazan, HE; Bazan, NG; Ma, X; Ottino, P1
Alloatti, G; Berta, G; Cappello, S; Gattullo, D; Losano, G; Mognetti, B; Pagliaro, P; Penna, C1
Hagiwara, K; Kanazawa, M; Kikuchi, I; Kikuchi, S; Kobayashi, T; Nagata, M; Sakamoto, Y1
Caporale, R; Cellai, C; Di Lollo, S; Laurenzana, A; Paglierani, M; Pancrazzi, A; Paoletti, F; Vannucchi, AM1
De Plaen, IG; Ghosh, S; Han, XB; Hsueh, W; Liu, X; May, MJ1
Azambuja, P; Garcia, ES; Machado, EM1
Calixto, JB; Kassuya, CA; Marotta, DM; Menezes-de-Lima, O; Rehder, VL; Silvestre, A1
Calorini, L; Fallani, A; Gabellieri, S; Mannini, A; Mugnai, G; Ruggieri, S1
Jancar, S; Machado, MC; Molan, NA; Shio, MT; Souza, LJ1
Peng, K; Tang, YL; Wang, S; Xu, ZX; Yang, YZ1
Chen, Z; Dupré, DJ; Larrivée, JF; Le Gouill, C; Rola-Pleszczynski, M; Rollin, S; Stanková, J; Thompson, C1
Fukuda, J; Furukawa, Y; Kawano, Y; Matsumoto, H; Narahara, H; Yuge, A1
Azambuja, P; Figueiredo, MB; Garcia, ES1
Bailey, SR; Cunningham, FM; Elliott, J; Menzies-Gow, NJ; Sepulveda, MF1
Abdallah, MF; Ibe, BO; Portugal, AM; Raj, JU1
Bloechle, C; Izbicki, JR; Kaifi, J; Kluth, D; Mann, O; Schneider, C; Strate, T; Tiefenbacher, WJ; Yekebas, E1
Anderson, R; Steel, HC; Tintinger, GR1
Calixto, JB; Campos, MM; Costa, R; Fernandes, ES; Marotta, DM; Medeiros, R; Motta, EM; Quintão, NL1
Anderson, R; Steel, HC; Theron, AJ; Tintinger, GR1
Borgeat, P; Flamand, N; Lefebvre, JS; Lévesque, T; Marleau, S; Milot, V; Picard, S1
Davoine, F; Druey, KM; Dyer, KD; Kim, JD; Lacy, P; Moqbel, R; Percopo, CM; Rosenberg, HF; Xie, Z; Yang, Z1
Barbiéri, CL; de Souza Carmo, EV; Katz, S1
Asaka, N; Kakuo, H; Kiniwa, M; Ohmori, K; Oka, T; Sasaki, E; Togawa, M; Yamada, S1
Alviano, CS; Alviano, DS; Atella, GC; Folly, E; Gomes, MT; Lopes, AH; Silva-Filho, FC; Zimmermann, LT1
Faez, S; Frimmel, SA; Garland, RC; Hafezi-Moghadam, A; Nakao, S; Schering, A; Sun, D; Tayyari, F; Xie, F; Zandi, S1
Abdel-Al, M; Ditmyer, M; Howard, KM; Patel, N1
Ajiro, Y; Giles, WR; Saegusa, N; Spitzer, KW; Stafforini, DM1
Arteaga, A; Bae, R; Ibe, BO; Raj, JU1
Demopoulos, CA; Papakyriakou, A; Philippopoulos, AI; Tsoupras, AB1
Andréasson, E; Bylund, J; Christenson, K; Dahlgren, C; Forsman, H; Karlsson, A; Önnheim, K1
Bessi, VL; Bitencourt, CS; Borgeat, P; Faccioli, LH; Hamdan, L; Huynh, DN; Lefebvre, JS; Lévesque, T; Marleau, S; Ménard, L; Sohouhenou, F1
Albano, RM; Carvalho, S; da Conceição Costa, J; de Carvalho, L; de Oliveira Lima Santos, SA; Mallet de Lima, CD; Plotkowski, MC; Saliba, AM; Teixeira, MM1
Almeida, IC; Gazos-Lopes, F; Gomes, MT; Hoelz, LV; Lopes, AH; Marques, AF; Monteiro, RQ; Nakayasu, ES; Oliveira, MM; Pascutti, PG; Salloum, NG; Souto-Padrón, T; Vieira, DP1
Sahu, RP1
Goto, S; Itoh, H; Nagai, M; Ohmori, K; Osada, H; Sasaki, K; Shimizu, S; Shimoda, M; Shirai, J; Watanabe, M1
Abhilasha, KV; Chaithra, VH; Chen, CH; Jacob, SP; Kemparaju, K; Lakshmikanth, CL; Marathe, GK; McIntyre, TM; Sahu, RP; Sumanth, MS; Thyagarajan, A; Travers, JB1
Cong, Q; Gao, T; Jiang, W; Sun, M; Wang, Y; Xu, C; Yao, L; Yu, Y1
Liu, L; Liu, ZL; Zhang, F; Zhang, H1

Reviews

14 review(s) available for triazoles and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine

ArticleYear
Platelet-activating factor receptor and signal transduction.
    Biochemical pharmacology, 1992, Sep-25, Volume: 44, Issue:6

    Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Azepines; Cloning, Molecular; GTP-Binding Proteins; Humans; Molecular Sequence Data; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Second Messenger Systems; Sequence Homology, Amino Acid; Signal Transduction; Triazoles

1992
Thieno-triazolo-1,4-diazepines as antagonists of platelet-activating factor: present status.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Animals; Azepines; Central Nervous System; Flumazenil; Humans; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazolam; Triazoles

1991
The effects of hetrazepine PAF antagonists in preclinical models of asthma.
    Agents and actions. Supplements, 1991, Volume: 34

    Topics: Anaphylaxis; Animals; Antigens; Asthma; Azepines; Blood Platelets; Bronchi; Bronchoconstriction; Capillary Permeability; Cell Movement; Eosinophils; Lung; Platelet Activating Factor; Respiratory Hypersensitivity; Triazoles

1991
[Phospholipid thrombocyte activating factor, its analogs and antagonists: prospects of their use in medicine].
    Vestnik Akademii meditsinskikh nauk SSSR, 1991, Issue:10

    Topics: Azepines; Diterpenes; Fibrinolytic Agents; Ginkgolides; Humans; In Vitro Techniques; Lactones; Lysophosphatidylcholines; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Thrombosis; Triazoles

1991
Role for platelet-activating factor in asthma.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Animals; Asthma; Azepines; Eosinophils; Humans; Muscle, Smooth; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System; Triazoles

1991
Hypoxia, PAF, and necrotizing enterocolitis.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Animals; Azepines; Enterocolitis; Humans; Hypoxia; Intestines; Necrosis; Platelet Activating Factor; Quinolinium Compounds; Triazoles

1991
Involvement of platelet-activating factor (PAF) in septic shock and priming as indicated by the effect of hetrazepinoic PAF antagonists.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Animals; Azepines; Endotoxins; Humans; Models, Biological; Multiple Organ Failure; Platelet Activating Factor; Shock, Septic; Triazoles

1991
From ginkgolides to N-substituted piperidino-thieno diazepines, a new series of highly potent dual antagonists.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21B

    Topics: Animals; Azepines; Diterpenes; Ginkgolides; Humans; Lactones; Piperidines; Plant Extracts; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles

1991
PAF antagonism as an approach to the treatment of airway hyperreactivity.
    The American review of respiratory disease, 1991, Volume: 143, Issue:3 Pt 2

    Topics: Allergens; Animals; Asthma; Azepines; Bronchoconstriction; Diterpenes; Ginkgolides; Humans; Lactones; Platelet Activating Factor; Triazoles

1991
New trends in PAF antagonist research: a new series of potent hetrapazine-derived PAF antagonists.
    Agents and actions, 1991, Volume: 32, Issue:1-2

    Topics: Animals; Azepines; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles

1991
Clinical experience with platelet-activating factor antagonists. Past, present, and near future.
    Clinical reviews in allergy, 1994,Winter, Volume: 12, Issue:4

    Topics: Animals; Azepines; Clinical Trials as Topic; Graft Rejection; Humans; Kidney Transplantation; Lactones; Plant Extracts; Platelet Activating Factor; Randomized Controlled Trials as Topic; Shock, Septic; Thienopyridines; Triazoles

1994
PAF-cytokine autocatalytic feed-back network in septic shock: involvement in acute renal failure.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9 Suppl 4

    Topics: Acute Kidney Injury; Animals; Azepines; Cytokines; Diterpenes; Down-Regulation; Feedback; Ginkgolides; Humans; Lactones; Lipopolysaccharides; Platelet Activating Factor; Shock, Septic; Triazoles

1994
Activation of the phospholipase/cyclooxygenase cascade in the rabbit cornea by platelet-activating factor is challenged by PAF receptor antagonists.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1995,Fall, Volume: 11, Issue:3

    Topics: Animals; Arachidonic Acid; Azepines; Cornea; Enzyme Activation; Phospholipases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles

1995
[PAF receptor antagonist in asthma therapy].
    Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:11

    Topics: Animals; Asthma; Azepines; Humans; Platelet Activating Factor; Triazoles

1996

Trials

10 trial(s) available for triazoles and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine

ArticleYear
Pharmacodynamics, pharmacokinetics and safety profile of the new platelet-activating factor antagonist apafant in man.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:1

    Topics: Adult; Azepines; Blood Cell Count; Blood Chemical Analysis; Blood Platelets; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Intestinal Absorption; Male; Middle Aged; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Binding; Random Allocation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1991
Inhibition of cutaneous and platelet responses to platelet-activating factor by oral WEB 2086 in man.
    The Journal of allergy and clinical immunology, 1991, Volume: 88, Issue:1

    Topics: Administration, Oral; Adult; Azepines; Dose-Response Relationship, Drug; Double-Blind Method; Histamine; Humans; Injections, Intradermal; Male; Placebos; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Skin; Skin Tests; Triazoles

1991
Inhibitory effects of the new PAF acether antagonist WEB-2086 on pharmacologic changes induced by PAF inhalation in human beings.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4

    Topics: Administration, Inhalation; Administration, Oral; Adult; Airway Resistance; Azepines; Bronchi; Bronchial Provocation Tests; Double-Blind Method; Hemodynamics; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Reproducibility of Results; Triazines; Triazoles

1990
Safety, tolerability, and pharmacologic activity of multiple doses of the new platelet activating factor antagonist WEB 2086 in human subjects.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:3

    Topics: Adult; Azepines; Blood Pressure; Double-Blind Method; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Pulse; Random Allocation; Respiration; Time Factors; Triazines; Triazoles

1989
Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma.
    American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:4 Pt 1

    Topics: Adult; Analysis of Variance; Asthma; Azepines; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles

1995
Quantitative measurement of BN50727 in human plasma and urine by combined liquid chromatography/negative ion chemical ionization mass spectrometry using a particle beam interface.
    Biological mass spectrometry, 1994, Volume: 23, Issue:9

    Topics: Adult; Azepines; Chromatography, High Pressure Liquid; Humans; Male; Mass Spectrometry; Platelet Activating Factor; Thienopyridines; Triazoles

1994
The effect of the orally active platelet-activating factor antagonist WEB 2086 in the treatment of asthma.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:5

    Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Aged; Albuterol; Asthma; Azepines; Beclomethasone; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Platelet Activating Factor; Triazoles

1994
Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses.
    Thorax, 1993, Volume: 48, Issue:6

    Topics: Administration, Oral; Adult; Asthma; Azepines; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Platelet Activating Factor; Respiratory Hypersensitivity; Time Factors; Triazoles

1993
Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan.
    Advances in experimental medicine and biology, 1996, Volume: 416

    Topics: Adolescent; Adult; Aged; Anti-Asthmatic Agents; Asthma; Azepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Treatment Outcome; Triazoles

1996
A double blind, placebo controlled study of a platelet activating factor antagonist in patients with rheumatoid arthritis.
    The Journal of rheumatology, 1998, Volume: 25, Issue:8

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azepines; Double-Blind Method; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Activating Factor; Platelet Aggregation Inhibitors; Thienopyridines; Treatment Outcome; Triazoles

1998

Other Studies

693 other study(ies) available for triazoles and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine

ArticleYear
Interactions of prostanoids with the platelet activating factors.
    Prostaglandins, leukotrienes, and essential fatty acids, 1992, Volume: 47, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Guinea Pigs; Heart; Iloprost; In Vitro Techniques; Indomethacin; Myocardial Contraction; Perfusion; Platelet Activating Factor; Prostaglandins; Sulfonamides; Thromboxane A2; Thromboxane B2; Triazoles

1992
Modulation of antigen- and ischemia-induced effects by the platelet-activating factor antagonist WEB-2086 in isolated sensitized rat hearts.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:5

    Topics: Anaphylaxis; Animals; Antigens; Azepines; Chromatography, High Pressure Liquid; Chromones; Coronary Circulation; Heart; Histamine Release; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Platelet Activating Factor; Pressure; Rats; Rats, Wistar; Triazoles

1992
Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.
    Biochemical and biophysical research communications, 1992, Dec-15, Volume: 189, Issue:2

    Topics: Amino Acid Sequence; Animals; Azepines; Base Sequence; Blotting, Northern; Cloning, Molecular; DNA; Electrophysiology; Gene Expression; Heart; Heart Ventricles; Humans; Male; Middle Aged; Molecular Sequence Data; Oligodeoxyribonucleotides; Oocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA; Triazoles; Xenopus

1992
Inhibition of platelet-activating factor fails to limit ischemia and reperfusion-induced myocardial damage.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:6

    Topics: Animals; Azepines; Blood Pressure; Coronary Circulation; Dogs; Heart Rate; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Platelet Activating Factor; Platelet Aggregation; Triazoles

1992
Endothelium-dependent effects of platelet-activating factor in the coronary circulation.
    Journal of cardiovascular pharmacology, 1992, Volume: 20 Suppl 12

    Topics: Animals; Azepines; Coronary Circulation; Coronary Vessels; Diterpenes; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Ginkgolides; Hemodynamics; Injections, Intra-Arterial; Injections, Intravenous; Lactones; Platelet Activating Factor; Saponins; Triazoles; Vascular Resistance; Vasoconstriction; Vasodilation

1992
PAF-acether induced arterial thrombosis and the effect of specific antagonists.
    Advances in experimental medicine and biology, 1992, Volume: 316

    Topics: Acetyltransferases; Animals; Azepines; Blood Platelets; Down-Regulation; Guinea Pigs; Hydrogen Peroxide; Hydrolases; Mesenteric Arteries; Phenylmethylsulfonyl Fluoride; Platelet Activating Factor; Thienopyridines; Thrombosis; Triazoles

1992
Inhibition of vincristine-induced retinal impairments by a specific PAF antagonist.
    Lens and eye toxicity research, 1992, Volume: 9, Issue:3-4

    Topics: Animals; Azepines; Electroretinography; Organ Culture Techniques; Perfusion; Photic Stimulation; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Retinal Diseases; Tetrazoles; Thienopyridines; Triazoles; Vincristine

1992
PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model.
    Lung, 1992, Volume: 170, Issue:1

    Topics: Animals; Azepines; Blood Pressure; Hydroxyproline; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Artery; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thymidine; Triazoles

1992
Platelet activating factor mediates interleukin-2-induced lung injury in the rat.
    The Journal of clinical investigation, 1992, Volume: 89, Issue:5

    Topics: Animals; Azepines; Blood Pressure; Interleukin-2; Leukocyte Count; Lung Diseases; Male; Peroxidase; Platelet Activating Factor; Platelet Count; Rats; Rats, Inbred Strains; Thromboxane B2; Triazoles; Tumor Necrosis Factor-alpha

1992
Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8.
    The Journal of cell biology, 1992, Volume: 117, Issue:3

    Topics: Antigens, Surface; Azepines; Cell Adhesion; Cell Movement; Cells, Cultured; Endothelium, Vascular; Female; Furans; Humans; Interleukin-8; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pregnancy; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stimulation, Chemical; Triazoles; Tumor Necrosis Factor-alpha; Umbilical Veins

1992
Effects of WEB 2086, an antagonist to the receptor for platelet-activating factor (PAF), on PAF-induced responses in the horse.
    Equine veterinary journal, 1992, Volume: 24, Issue:3

    Topics: Animals; Azepines; Capillary Permeability; Cell Migration Inhibition; Cell Movement; Dose-Response Relationship, Drug; Horses; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1992
Existence of PAF receptors in human platelets and human lung tissue but not in the human myocardium.
    American heart journal, 1992, Volume: 124, Issue:2

    Topics: Azepines; Blood Platelets; Coronary Vessels; Depression, Chemical; Humans; In Vitro Techniques; Isometric Contraction; Lung; Middle Aged; Myocardial Contraction; Myocardium; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1992
Platelet-activating factor inhibits proteoglycan synthesis and enhances neutrophil-mediated proteoglycan degradation in cartilage explants.
    Arthritis and rheumatism, 1992, Volume: 35, Issue:8

    Topics: Animals; Azepines; Cartilage, Articular; Cattle; Cells, Cultured; Granulocyte-Macrophage Colony-Stimulating Factor; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sulfur Radioisotopes; Triazoles; Tumor Necrosis Factor-alpha

1992
Immune-complex alveolitis in the rat: evidence for platelet activating factor and leukotrienes as mediators of the vascular lesions.
    European journal of pharmacology, 1992, Mar-17, Volume: 213, Issue:1

    Topics: Alveolitis, Extrinsic Allergic; Animals; Azepines; Bronchoalveolar Lavage Fluid; Dinoprostone; Diterpenes; Econazole; Ginkgolides; Hemoglobins; Hemorrhage; Indomethacin; Lactones; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Propionates; Quinolines; Rats; Rats, Inbred Strains; Thromboxanes; Triazoles

1992
Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor.
    British journal of pharmacology, 1992, Volume: 105, Issue:4

    Topics: Animals; Azepines; Dexamethasone; Diterpenes; Gastric Mucosa; Ginkgolides; Lactones; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles

1992
Characterization of the antagonist activity of the PAF antagonists RP 59227 and WEB 2086 on elicited guinea pig peritoneal macrophages. Evidence for variable affinities and kinetics.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:3

    Topics: Animals; Azepines; Guinea Pigs; Humans; Kinetics; Macrophages; Male; Neutrophils; Peritoneum; Platelet Activating Factor; Pyridines; Superoxides; Thiazoles; Triazoles

1992
Reversible or irreversible modification of [3H]PAF binding on rabbit platelet membranes differentiates various PAF receptor antagonists.
    Lipids, 1992, Volume: 27, Issue:8

    Topics: Animals; Azepines; Blood Platelets; Cell Membrane; Dioxolanes; Diterpenes; Furans; Ginkgolides; Lactones; Molecular Structure; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Quinolinium Compounds; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tritium

1992
Effects of nedocromil sodium and WEB 2086 on chemoattractant-stimulated neutrophil migration through cellular and noncellular barriers.
    Annals of allergy, 1992, Volume: 69, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Azepines; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Nedocromil; Neutrophils; Platelet Activating Factor; Quinolones; Triazoles

1992
The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction.
    British journal of pharmacology, 1992, Volume: 107, Issue:1

    Topics: Animals; Arthus Reaction; Azepines; Complement System Proteins; Edema; Isoquinolines; Leukotriene B4; Platelet Activating Factor; Rabbits; Radioimmunoassay; Receptors, Complement; Tetrazoles; Triazoles; Zymosan

1992
Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor.
    Vox sanguinis, 1992, Volume: 63, Issue:2

    Topics: Azepines; Blood Platelets; Enzyme Activation; Erythrocytes; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1992
Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992, Volume: 13, Issue:4

    Topics: Animals; Azepines; Binding Sites; Brain; Capillaries; Cattle; Cells, Cultured; Endothelium, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1992
Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites.
    Biochemical and biophysical research communications, 1992, Dec-15, Volume: 189, Issue:2

    Topics: Alkaloids; Azepines; Binding Sites; Calcium; Drug Synergism; Humans; In Vitro Techniques; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Triazoles

1992
[Interference of platelet-activating factor antagonist, BN50739 with the releasing of inflammatory mediators from anaphylactic lung of guinea pig].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1992, Volume: 15, Issue:6

    Topics: Alveolitis, Extrinsic Allergic; Animals; Azepines; Female; Guinea Pigs; Histamine; Lung; Male; Ovalbumin; Platelet Activating Factor; Prostaglandins F; SRS-A; Thromboxane B2; Triazoles

1992
Triazolam and PAF inhibition.
    Lancet (London, England), 1992, Jan-04, Volume: 339, Issue:8784

    Topics: Azepines; Clinical Trials as Topic; Drug Administration Schedule; Humans; Platelet Activating Factor; Triazolam; Triazoles

1992
Leukotriene B4 mediates shear rate-dependent leukocyte adhesion in mesenteric venules.
    Circulation research, 1992, Volume: 71, Issue:4

    Topics: Animals; Antigens, CD; Azepines; Benzopyrans; Cats; CD18 Antigens; Endothelium, Vascular; Indoles; Leukocytes; Leukotriene B4; Mesenteric Veins; Platelet Activating Factor; Receptors, Leukocyte-Adhesion; Triazoles; Venules

1992
Interference of azelastine with anaphylaxis induced by ovalbumin challenge in actively sensitized rats.
    European journal of pharmacology, 1992, Mar-24, Volume: 213, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Dihydropyridines; Dose-Response Relationship, Drug; Hematocrit; Histamine H1 Antagonists; Leukocyte Count; Male; Meclizine; Ovalbumin; Phthalazines; Platelet Activating Factor; Platelet Count; Rats; Rats, Inbred Strains; Terfenadine; Triazoles

1992
[Effects of anti-PAF agents on nasal response after allergen challenge in guinea pigs].
    Nihon Jibiinkoka Gakkai kaiho, 1992, Volume: 95, Issue:8

    Topics: Airway Resistance; Allergens; Animals; Azepines; Guinea Pigs; Histamine H1 Antagonists; Male; Nasal Provocation Tests; Nose; Phthalazines; Platelet Activating Factor; Triazoles

1992
Influence of platelet activating factor antagonists on the protamine sulphate stimulated release of histamine from peritoneal mast cells of rats in vitro.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:1

    Topics: Acetophenones; Animals; Azepines; Diterpenes; Ginkgolides; Histamine Release; Humans; In Vitro Techniques; Ketotifen; Lactones; Male; Mast Cells; Peritoneal Cavity; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Protamines; Rats; Rats, Inbred Strains; Triazoles

1992
Regulation of hepatic glycogenolysis and vasoconstriction during antigen-induced anaphylaxis.
    The American journal of physiology, 1992, Volume: 262, Issue:5 Pt 1

    Topics: Anaphylaxis; Animals; Antigens; Azepines; Eicosanoids; Epitopes; Female; Glycogen; Liver; Nitric Oxide; Ovalbumin; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles; Vasoconstriction

1992
The role of nitric oxide and platelet-activating factor in the inhibition by endotoxin of pentagastrin-stimulated gastric acid secretion.
    European journal of pharmacology, 1992, Aug-06, Volume: 218, Issue:2-3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Azepines; Endotoxins; Female; Gastric Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentagastrin; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles

1992
Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor.
    Agents and actions, 1992, Volume: 35, Issue:3-4

    Topics: Animals; Arthus Reaction; Azepines; Capillary Permeability; Disease Models, Animal; Female; Guinea Pigs; Male; Molecular Structure; Ovalbumin; Pancreatitis; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Skin; Skin Diseases; Triazoles

1992
Platelet activating factor and systemic anaphylaxis in Nippostrongylus brasiliensis-sensitized rats: differential effects of PAF antagonists.
    British journal of pharmacology, 1992, Volume: 106, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Blood Proteins; Diterpenes; Evans Blue; Ginkgolides; Hemodynamics; Lactones; Male; Microspheres; Nippostrongylus; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles

1992
PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 73, Issue:3

    Topics: Animals; Azepines; Endothelins; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Pulmonary Circulation; Rats; Triazoles; Vasoconstriction

1992
Role of platelet-activating factor in the development of endothelial dysfunction in hemorrhagic hypotension and retransfusion.
    Thrombosis research, 1992, Apr-01, Volume: 66, Issue:1

    Topics: Animals; Azepines; Blood Transfusion; Cats; Cerebrovascular Disorders; Endothelium, Vascular; Hemorrhage; Hypotension; Male; Platelet Activating Factor; Triazoles

1992
Differential effects of WEB 2086 and SRI 63-441 on TNF-alpha-induced alterations in cardiopulmonary function.
    The American journal of physiology, 1992, Volume: 263, Issue:3 Pt 2

    Topics: Animals; Azepines; ErbB Receptors; Heart; Indomethacin; Lipids; Lung; Platelet Activating Factor; Platelet Aggregation; Quinolinium Compounds; Swine; Triazoles; Tumor Necrosis Factor-alpha

1992
Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma.
    The American journal of physiology, 1992, Volume: 263, Issue:4 Pt 2

    Topics: Animals; Azepines; Behavior, Animal; Body Water; Brain; Brain Injuries; Cations; Dialysis; Diterpenes; Ginkgolides; Glycine; Lactones; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles

1992
Platelet-activating factor antagonists in experimental shock.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:8

    Topics: Acid-Base Equilibrium; Animals; Azepines; Blood Pressure; Electrocardiography; Endotoxins; Hyperkalemia; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Shock; Triazoles

1992
Activation of leukocytes with complement C5a is associated with prostanoid-dependent constriction of large arteries in atherosclerotic monkeys in vivo.
    Atherosclerosis, 1992, Volume: 95, Issue:2-3

    Topics: Animals; Arteries; Arteriosclerosis; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Complement C5a; Fatty Acids, Unsaturated; Hemodynamics; Hydrazines; Leukocytes; Lipids; Macaca fascicularis; Male; Platelet Activating Factor; Prostaglandins; Thromboxane A2; Triazoles; Vasoconstriction

1992
Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion.
    Hepatology (Baltimore, Md.), 1992, Volume: 16, Issue:5

    Topics: Alanine Transaminase; Allopurinol; Animals; Azepines; Gadolinium; Hepatitis; Ischemia; Leukocytes; Liver; Male; Necrosis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Triazoles

1992
Role of platelet-activating factor in hepatic responses after bile duct ligation in rats.
    The American journal of physiology, 1992, Volume: 263, Issue:5 Pt 1

    Topics: Animals; Azepines; Bile Ducts; Cholestasis; Diterpenes; Endotoxins; Ginkgolides; Kupffer Cells; Lactones; Ligation; Lipopolysaccharides; Liver; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles

1992
The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils.
    Agents and actions, 1992, Volume: 37, Issue:1-2

    Topics: Adult; Asthma; Azepines; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Eosinophils; Female; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; SRS-A; Triazoles

1992
Interactions of tumor necrosis factor with local and systemic factors in fetal rat limb bones.
    Calcified tissue international, 1992, Volume: 51, Issue:5

    Topics: Animals; Azepines; Bone and Bones; Bone Resorption; Culture Techniques; Dexamethasone; Hindlimb; Indomethacin; Interferon-gamma; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Parathyroid Hormone; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins; Transforming Growth Factor beta; Triazoles; Tumor Necrosis Factor-alpha

1992
Influence of a platelet-activating factor antagonist on severe pancreatitis in two experimental models.
    International journal of pancreatology : official journal of the International Association of Pancreatology, 1992, Volume: 12, Issue:2

    Topics: Animals; Ascites; Azepines; Male; Pancreatitis; Platelet Activating Factor; Rats; Rats, Wistar; Survival Rate; Triazoles

1992
Aggregation of human polymorphonuclear leukocytes by endothelin: role of platelet-activating factor.
    European journal of pharmacology, 1992, Dec-02, Volume: 224, Issue:2-3

    Topics: Azepines; Calcium; Cell Aggregation; Centrifugation, Density Gradient; Cytosol; Diterpenes; Dose-Response Relationship, Drug; Endothelins; Ginkgolides; Humans; Lactones; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Triazoles

1992
Effects of the PAF antagonists BN50726 and BN50739 on arrhythmogenesis and extent of necrosis during myocardial ischaemia/reperfusion in rabbits.
    British journal of pharmacology, 1992, Volume: 107, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Azepines; Blood Pressure; Electrocardiography; Heart Rate; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Necrosis; Platelet Activating Factor; Rabbits; Thienopyridines; Triazoles

1992
Pulmonary vascular reactivity: effect of PAF and PAF antagonists.
    Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 73, Issue:5

    Topics: Angiotensin II; Animals; Azepines; Hypoxia; In Vitro Techniques; Male; Phospholipid Ethers; Platelet Activating Factor; Pulmonary Circulation; Pulmonary Edema; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Triazoles; Vasoconstriction; Vasodilation

1992
Platelet-activating factor as an intercellular signal in neutrophil-dependent platelet activation.
    Journal of immunology (Baltimore, Md. : 1950), 1992, Sep-01, Volume: 149, Issue:5

    Topics: Amino Acid Sequence; Animals; Azepines; Blood Platelets; Cells, Cultured; Fibrinogen; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Signal Transduction; Thromboxane A2; Triazoles

1992
The effects of a PAF antagonist on ischemic myocardial damage and arrhythmia in the dog.
    Journal of molecular and cellular cardiology, 1992, Volume: 24, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Azepines; Coronary Disease; Dogs; Myocardial Reperfusion Injury; Platelet Activating Factor; Tachycardia; Triazoles; Ventricular Fibrillation

1992
Mechanisms of the cardioprotective actions of WEB-2170, bepafant, a platelet activating factor antagonist, in myocardial ischemia and reperfusion.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3

    Topics: Animals; Azepines; Cats; Cell Adhesion; Coronary Disease; Creatine Kinase; Endothelium, Vascular; Heart; Hemodynamics; Male; Myocardial Reperfusion Injury; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Triazoles

1992
Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor.
    Scandinavian journal of gastroenterology, 1992, Volume: 27, Issue:2

    Topics: Animals; Azepines; Blood Pressure; Burns; Gastric Mucosa; Hemodynamics; Hemoglobins; Male; Oxygen; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Regional Blood Flow; Thiazoles; Thiazolidines; Triazoles

1992
Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat.
    The American journal of pathology, 1992, Volume: 140, Issue:4

    Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Diterpenes; Eicosanoids; Enzymes; Ginkgolides; Lactones; Lung; Pancreatitis; Platelet Activating Factor; Rats; Triazoles

1992
Studies on xenograft rejection: the role of leukocytes and prostaglandins and their modulation by the hetrazepine WEB 2086BS.
    Transplantation proceedings, 1992, Volume: 24, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Erythrocyte Count; Graft Rejection; Hemagglutinins; Hemoperfusion; Humans; Kidney Transplantation; Leukocytes; Platelet Activating Factor; Swine; Thromboxane B2; Transplantation, Heterologous; Triazoles

1992
Effect of WEB 2086 on myocardial infarct size and regional blood flow in the dog.
    Cardiovascular research, 1992, Volume: 26, Issue:2

    Topics: Animals; Azepines; Cardiac Output; Coronary Disease; Disease Models, Animal; Dogs; Myocardial Infarction; Myocardium; Platelet Activating Factor; Regional Blood Flow; Triazoles

1992
WEB 2086 inhibits neutrophil dependent increases in coronary resistance in blood perfused rabbit heart.
    Cardiovascular research, 1992, Volume: 26, Issue:2

    Topics: Animals; Azepines; Disease Models, Animal; Myocardial Reperfusion Injury; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Triazoles; Vascular Resistance

1992
Inhibition of neutrophil respiratory burst and degranulation responses to platelet-activating factor by antagonists WEB 2086, CV 6209 and CV 3988.
    International archives of allergy and immunology, 1992, Volume: 97, Issue:1

    Topics: Azepines; Cell Degranulation; Cell Survival; Humans; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Pyridinium Compounds; Respiratory Burst; Triazoles

1992
Release of platelet-activating factor is important for the respiratory burst induced in human eosinophils by opsonized particles.
    Blood, 1992, May-15, Volume: 79, Issue:10

    Topics: Azepines; Eosinophils; Humans; In Vitro Techniques; Kinetics; Oxygen Consumption; Phospholipases A; Platelet Activating Factor; Triazoles; Zymosan

1992
Inhibition of aeroallergen-induced bronchial eosinophilia by azelastine in guinea pigs.
    International archives of allergy and immunology, 1992, Volume: 97, Issue:3

    Topics: Administration, Oral; Animals; Azepines; Bronchodilator Agents; Dose-Response Relationship, Drug; Guinea Pigs; Leukocyte Count; Leukocytes, Mononuclear; Male; Methylprednisolone; Phthalazines; Platelet Activating Factor; Pulmonary Eosinophilia; Theophylline; Triazoles

1992
Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils.
    Journal of immunology (Baltimore, Md. : 1950), 1992, Jun-01, Volume: 148, Issue:11

    Topics: Azepines; Calcimycin; Calcium; Cytosol; Dinoprostone; Eosinophils; Histamine; Histamine Antagonists; Humans; In Vitro Techniques; Lung; Mast Cells; Neutrophils; Piperidines; Platelet Activating Factor; Prostaglandin D2; Secretory Rate; SRS-A; Triazoles

1992
Attenuation of platelet-activating factor-induced airway responses with methylprednisolone succinate in sheep.
    Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 72, Issue:4

    Topics: Airway Resistance; Animals; Azepines; Bronchoconstriction; Carbachol; Eicosanoids; Indomethacin; Methylprednisolone Hemisuccinate; Platelet Activating Factor; Propionates; Quinolines; Respiratory Mechanics; Sheep; SRS-A; Triazoles

1992
RP 59227, a novel PAF receptor antagonist: effects in guinea pig models of airway hyperreactivity.
    European journal of pharmacology, 1992, Jan-07, Volume: 210, Issue:1

    Topics: Animals; Antigens; Azepines; Bronchial Hyperreactivity; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Guinea Pigs; Male; Ovalbumin; Platelet Activating Factor; Pyridines; Thiazoles; Triazoles

1992
Platelet-activating factor reduces spinal cord blood flow and causes behavioral deficits after intrathecal administration in rats through a specific receptor mechanism.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Animals; Azepines; Blood Pressure; Dose-Response Relationship, Drug; Injections, Spinal; Male; Motor Activity; Platelet Activating Factor; Rats; Rats, Inbred Strains; Spinal Cord; Triazoles

1992
Hapten synthesis for (+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5-tet rahydro-8H-pyrido[4',3':4,5]thieno[3,2-f] triazolo[4,3-a][1,4]diazepine (E6123).
    Chemical & pharmaceutical bulletin, 1992, Volume: 40, Issue:3

    Topics: Azepines; Chromatography; Haptens; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Platelet Activating Factor; Radioimmunoassay; Triazoles

1992
Hemodynamic effects of endotoxin and platelet activating factor in cirrhotic rats.
    Gastroenterology, 1992, Volume: 103, Issue:1

    Topics: Animals; Azepines; Blood Pressure; Diterpenes; Endotoxins; Ginkgolides; Heart Rate; Hemodynamics; Lactones; Liver Cirrhosis, Experimental; Male; Platelet Activating Factor; Portal System; Rats; Rats, Inbred Strains; Triazoles

1992
1,5-Benzodiazepines. X. Dialkylamino substituted 1,5-benzodiazepine and [1,2,4]triazolo [4,3-a][1,5] benzodiazepine derivatives with inhibitory activity on PAF-induced platelet aggregation.
    Farmaco (Societa chimica italiana : 1989), 1992, Volume: 47, Issue:1

    Topics: Benzodiazepines; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Triazoles

1992
Differential inhibition by the PAF receptor antagonist, WEB 2170, of allergic inflammation in single sensitized and boosted mice.
    European journal of pharmacology, 1992, Jan-28, Volume: 211, Issue:1

    Topics: Animals; Antigens; Azepines; Dose-Response Relationship, Drug; Edema; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Platelet Activating Factor; Triazoles

1992
Platelet-activating factor stimulates phospholipase C activity in human endometrium.
    Journal of cellular physiology, 1992, Volume: 152, Issue:1

    Topics: Adult; Azepines; Cells, Cultured; Chromatography, Ion Exchange; Dose-Response Relationship, Drug; Endometrium; Female; Humans; Inositol; Inositol Phosphates; Middle Aged; Platelet Activating Factor; Time Factors; Triazoles; Type C Phospholipases

1992
Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.
    Agents and actions. Supplements, 1992, Volume: 37

    Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Azepines; Clemastine; Coronary Disease; Coronary Vessels; Guinea Pigs; Organoselenium Compounds; Ouabain; Piperidines; Platelet Activating Factor; Propranolol; Rats; Triazoles; Umbelliferones; Ventricular Fibrillation

1992
Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor.
    The Journal of biological chemistry, 1991, Jun-15, Volume: 266, Issue:17

    Topics: Azepines; Cell Adhesion; Furans; Humans; Hydrolysis; In Vitro Techniques; Indicators and Reagents; Kinetics; Neutrophils; Oxidation-Reduction; Phosphatidylcholines; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1991
LTB4, a potent chemotactic factor for purified guinea-pig eosinophils: interference of PAF-acether antagonists.
    International journal of immunopharmacology, 1991, Volume: 13, Issue:2-3

    Topics: Animals; Azepines; Chemotaxis, Leukocyte; Diterpenes; Eosinophils; Female; Ginkgolides; Guinea Pigs; In Vitro Techniques; Lactones; Leukotriene B4; Male; Platelet Activating Factor; Triazoles

1991
Platelet activating factor-induced shock and intestinal necrosis in the rat: role of endogenous platelet-activating factor and effect of saline infusion.
    Critical care medicine, 1991, Volume: 19, Issue:8

    Topics: Animals; Azepines; Intestine, Large; Isotonic Solutions; Male; Necrosis; Peroxidase; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock; Sodium Chloride; Triazoles

1991
The platelet activating factor receptor antagonist, RP 59227, blocks platelet activating factor receptors mediating liberation of reactive oxygen species in guinea pig macrophages and human polymorphonuclear leukocytes.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2

    Topics: Animals; Azepines; Glyceryl Ethers; Guinea Pigs; Humans; Luminescent Measurements; Macrophages; Male; Neutrophils; Oxygen; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles

1991
Regulation of eicosanoid generation in activated macrophages.
    International archives of allergy and applied immunology, 1991, Volume: 95, Issue:1

    Topics: Animals; Azepines; Dexamethasone; Epoprostenol; Macrophage Activation; Macrophages; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1991
Platelet-activating factor synergizes with phorbol myristate acetate in activating phospholipase D in the human promonocytic cell line U937. Evidence for different mechanisms of activation.
    The Journal of biological chemistry, 1991, Oct-05, Volume: 266, Issue:28

    Topics: Azepines; Cell Line; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Glycerophospholipids; Humans; Kinetics; Monocytes; Phosphatidic Acids; Phosphatidylinositols; Phospholipase D; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Triazoles; Type C Phospholipases

1991
Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:1

    Topics: Animals; Azepines; Blood Platelets; Bronchoconstriction; Guinea Pigs; Humans; Injections, Intravenous; Leukopenia; Male; Mice; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thrombocytopenia; Triazoles

1991
Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:1

    Topics: Animals; Azepines; Binding Sites; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Dogs; Guinea Pigs; Humans; Male; Phenanthridines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles

1991
Mechanisms of platelet activating factor-induced changes in sheep tracheal blood flow.
    British journal of pharmacology, 1991, Volume: 103, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Chromones; Cimetidine; Dose-Response Relationship, Drug; Female; Indomethacin; Methacholine Compounds; Muscle Tonus; Muscle, Smooth; Nedocromil; Platelet Activating Factor; Pyrilamine; Quinolones; Regional Blood Flow; Sheep; Trachea; Triazoles; Vascular Resistance

1991
Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.
    The Journal of biological chemistry, 1991, Oct-25, Volume: 266, Issue:30

    Topics: Amino Acid Sequence; Animals; Azepines; Base Sequence; Blotting, Northern; Cell Line; Cloning, Molecular; DNA; Guinea Pigs; Humans; Leukocytes; Membrane Potentials; Molecular Sequence Data; Ovum; Phosphatidylinositols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Conformation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles; Xenopus laevis

1991
Resistance and exchange microvessels are modulated by different PAF receptors.
    The American journal of physiology, 1991, Volume: 261, Issue:5 Pt 2

    Topics: Animals; Arterioles; Azepines; Capillary Permeability; Cheek; Cricetinae; Dose-Response Relationship, Drug; Kinetics; Male; Mesocricetus; Mouth Mucosa; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Vasoconstriction

1991
The effect of platelet-activating factor on the generation of superoxide anion in human eosinophils and neutrophils.
    The Journal of allergy and clinical immunology, 1991, Volume: 88, Issue:5

    Topics: Adult; Asthma; Azepines; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Eosinophils; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Neutrophils; Platelet Activating Factor; Rhinitis; Superoxides; Triazoles

1991
Molecular and cellular actions of platelet-activating factor in rat heart cells.
    The Journal of clinical investigation, 1991, Volume: 88, Issue:6

    Topics: Animals; Azepines; Cells, Cultured; Dose-Response Relationship, Drug; Heart; Myocardial Contraction; Phosphatidylinositols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1991
Receptor-mediated increase in cytosolic calcium in LLC-PK1 cells by platelet activating factor and thromboxane A2.
    Kidney international, 1991, Volume: 40, Issue:6

    Topics: Animals; Azepines; Calcium; Carbazoles; Cell Line; Cytosol; Kidney Tubules, Proximal; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Prostaglandin; Receptors, Thromboxane; Tetrazoles; Thienopyridines; Thromboxane A2; Triazoles

1991
Species-dependent differences of high affinity [3H]PAF-binding to platelets from humans and pigs and its inhibition by selected antagonists.
    Journal of lipid mediators, 1991, Volume: 4, Issue:3

    Topics: Animals; Azepines; Blood Platelets; Diterpenes; Ginkgolides; Humans; Lactones; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Swine; Triazoles

1991
PAF-mediated platelet adhesion to endothelial cells induced by FMLP-stimulated leukocytes.
    Journal of lipid mediators, 1991, Volume: 4, Issue:3

    Topics: Azepines; Endothelium, Vascular; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Triazoles; Umbilical Veins

1991
Quantitative assessment of increased airway microvascular permeability to 125I-labelled plasma fibrinogen induced by platelet activating factor and bradykinin.
    British journal of pharmacology, 1991, Volume: 104, Issue:1

    Topics: Animals; Autoradiography; Azepines; Bradykinin; Capillary Permeability; Fibrinogen; Guinea Pigs; Iodine Radioisotopes; Lung; Male; Paraffin Embedding; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pulmonary Circulation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Trachea; Triazoles

1991
1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine: an analogue of platelet-activating factor with partial agonist activity.
    British journal of pharmacology, 1991, Volume: 104, Issue:1

    Topics: Animals; Azepines; Blood Platelets; Calcium; Guinea Pigs; In Vitro Techniques; Macrophages; Male; Oxygen Consumption; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Signal Transduction; Superoxides; Triazoles

1991
Effects of antiplatelet agents on platelet aggregation induced by platelet--activating factor (PAF) in human whole blood.
    Prostaglandins, 1991, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Azepines; Dose-Response Relationship, Drug; Humans; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1991
Differential actions of platelet-activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused heart.
    British journal of pharmacology, 1991, Volume: 104, Issue:4

    Topics: Animals; Azepines; Coronary Vessels; Heart; In Vitro Techniques; Indoles; Piperazines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Vasoconstriction; Vasodilation

1991
Effects of endothelin-1 on vascular permeability in the conscious rat: interactions with platelet-activating factor.
    British journal of pharmacology, 1991, Volume: 104, Issue:4

    Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Diterpenes; Endothelins; Ginkgolides; Hematocrit; In Vitro Techniques; Lactones; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1991
Platelet-activating factor may participate in signal transduction processes in rabbit leukocytes.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Animals; Arachidonic Acid; Azepines; Blood Platelets; Calcimycin; Chloroquine; Female; Kinetics; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pyridinium Compounds; Rabbits; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Triazoles

1991
Pharmacological properties of YM461, a new orally active platelet-activating factor antagonist.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Administration, Oral; Animals; Azepines; Blood Platelets; Blood Pressure; Cell Membrane; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles

1991
Platelet-activating factor (PAF) receptor antagonists inhibit arachidonic acid induced platelet aggregation in rabbit whole blood.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Azepines; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles

1991
Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; Aspirin; Azepines; Cimetidine; Dexamethasone; Edema; Male; Meclizine; Methysergide; Mice; Ovalbumin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrazoles; Triazoles

1991
Inflammatory edema induced by interactions between IL-1 and the neuropeptide calcitonin gene-related peptide.
    Journal of immunology (Baltimore, Md. : 1950), 1991, May-15, Volume: 146, Issue:10

    Topics: Animals; Azepines; Calcitonin Gene-Related Peptide; Capillary Permeability; Complement C5a; Dinoprostone; Drug Synergism; Edema; Histamine H1 Antagonists; In Vitro Techniques; Interleukin-1; Male; Neutrophils; Platelet Activating Factor; Protein Synthesis Inhibitors; Rabbits; Triazoles

1991
Histamine, leukotriene D4 and platelet-activating factor in guinea pig passive cutaneous anaphylaxis.
    European journal of pharmacology, 1991, Nov-05, Volume: 204, Issue:2

    Topics: Acetophenones; Animals; Autacoids; Azepines; Blood Proteins; Bradykinin; Capillary Permeability; Chlorpheniramine; Cimetidine; Guinea Pigs; Histamine; Male; Methysergide; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; SRS-A; Tetrazoles; Triazoles

1991
Antagonists of embryo-derived platelet-activating factor act by inhibiting the ability of the mouse embryo to implant.
    Journal of reproduction and fertility, 1990, Volume: 88, Issue:1

    Topics: Animals; Azepines; Blastocyst; Decidua; Embryo Implantation; Embryo Transfer; Epoprostenol; Female; Iloprost; Mice; Mice, Inbred Strains; Platelet Activating Factor; Pregnancy; Quinolinium Compounds; Triazines; Triazoles; Trophoblasts

1990
Inhibition of PAF-induced histamine secretion and bronchoconstriction by WEB 2086.
    Research communications in chemical pathology and pharmacology, 1990, Volume: 67, Issue:1

    Topics: Animals; Azepines; Bronchi; Cromolyn Sodium; Guinea Pigs; Histamine Release; In Vitro Techniques; Leukocytes; Male; Muscle, Smooth; Platelet Activating Factor; Rabbits; Triazines; Triazoles

1990
Ro 19-3704 directly inhibits immunoglobulin E-dependent mediator release by a mechanism independent of its platelet-activating factor antagonist properties.
    European journal of pharmacology, 1990, Feb-13, Volume: 176, Issue:3

    Topics: Animals; Azepines; Diterpenes; Ginkgolides; Glyceryl Ethers; Histamine Release; Humans; Immunoglobulin E; Inositol Phosphates; L-Lactate Dehydrogenase; Lactones; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Substance P; Synovial Fluid; Thiazoles; Triazines; Triazoles; Tumor Cells, Cultured

1990
Characterization of cardiovascular events mediated by platelet activating factor during systemic anaphylaxis.
    Journal of cardiovascular pharmacology, 1990, Volume: 15, Issue:6

    Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Azepines; Blood Pressure; Cardiac Output; Cimetidine; Electrocardiography; Female; Guinea Pigs; Heart Rate; Hemodynamics; Histamine; Male; Myocardial Contraction; Ovalbumin; Platelet Activating Factor; Pyrilamine; Triazoles

1990
Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat.
    The American journal of pathology, 1990, Volume: 137, Issue:6

    Topics: Amylases; Animals; Azepines; Chronic Disease; Diterpenes; Ginkgolides; Lactones; Ligation; Male; Pancreas; Pancreatic Ducts; Pancreatitis; Platelet Activating Factor; Rats; Rats, Inbred Strains; Time Factors; Triazoles

1990
Effects of platelet-activating factor on myocardial contraction and myocardial relaxation of isolated perfused guinea pig hearts.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:5

    Topics: Animals; Azepines; Calcium; Coronary Circulation; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Perfusion; Platelet Activating Factor; Triazoles

1990
Gastric mucosal damage by ethanol is mediated by substance P and prevented by ketotifen, a mast cell stabilizer.
    Gastroenterology, 1991, Volume: 100, Issue:5 Pt 1

    Topics: Animals; Azepines; Cimetidine; Ethanol; Gastric Acid; Gastric Mucosa; Gastrins; Hydroxyzine; In Vitro Techniques; Ketotifen; Leukotriene B4; Male; Mast Cells; Pepsin A; Peptide Fragments; Platelet Activating Factor; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; SRS-A; Substance P; Triazoles

1991
Primed neutrophils injure rat lung through a platelet-activating factor-dependent mechanism.
    The Journal of surgical research, 1991, Volume: 50, Issue:5

    Topics: Animals; Azepines; Lipopolysaccharides; Lung; Lung Diseases; Male; Neutrophils; Nitroblue Tetrazolium; Oligopeptides; Peroxidase; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serum Albumin; Staining and Labeling; Triazoles

1991
Demonstration of platelet activating factor receptor in guinea pig kidney.
    Biochemical and biophysical research communications, 1991, May-31, Volume: 177, Issue:1

    Topics: Animals; Azepines; Blotting, Northern; Cell Membrane; Guinea Pigs; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Medulla; Kinetics; Membrane Proteins; Platelet Activating Factor; Platelet Membrane Glycoproteins; Poly A; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA; RNA, Messenger; Triazoles

1991
The effect of inhibitors of platelet aggregation on the metabolism of platelet-activating factor (PAF) in washed rabbit platelets.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Animals; Azepines; Blood Platelets; Chromatography, High Pressure Liquid; Iloprost; Kinetics; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinolinium Compounds; Rabbits; Triazoles; Tritium

1991
Infarct reduction by the platelet activating factor antagonist apafant in rats.
    Stroke, 1992, Volume: 23, Issue:1

    Topics: Animals; Azepines; Cerebral Infarction; Cerebrovascular Circulation; Platelet Activating Factor; Rats; Rats, Inbred F344; Triazoles

1992
Future horizons of lung preservation by application of a platelet-activating factor antagonist compared with current clinical standards. Euro-Collins flush perfusion versus donor core cooling.
    The Journal of thoracic and cardiovascular surgery, 1992, Volume: 103, Issue:2

    Topics: Animals; Azepines; Cold Temperature; Dogs; Epoprostenol; Heart-Lung Transplantation; Hemodynamics; Hypertonic Solutions; Organ Preservation; Oxygen; Platelet Activating Factor; Pulmonary Circulation; Triazoles

1992
Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Furans; Hemolysis; Humans; Hypotension; Isoquinolines; Male; Microsomes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridinium Compounds; Rabbits; Rats; Rats, Inbred Strains; Shock, Septic; Tetrahydroisoquinolines; Triazoles

1992
A role for phospholipid-derived inflammatory mediators in intestinal anaphylaxis in the rat.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Biological Transport; Carbazoles; Dinoprostone; Electrolytes; Female; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Jejunum; Leukotriene Antagonists; Leukotrienes; Phospholipids; Platelet Activating Factor; Propionates; Quinolines; Rats; Thromboxanes; Triazoles

1992
Role of platelet-activating factor in mediating tumor necrosis factor alpha-induced pulmonary vasoconstriction and plasma-lymph protein transport.
    The American review of respiratory disease, 1991, Volume: 144, Issue:6

    Topics: Animals; Azepines; Capillary Permeability; Lymphatic System; Male; Platelet Activating Factor; Pulmonary Veins; Sheep; Triazoles; Tumor Necrosis Factor-alpha; Vasoconstriction

1991
[Effects of the PAF antagonist WEB 2086 on hypoxia and angiotensin II-induced pulmonary vasoconstriction in the isolated perfused rat lung].
    Pneumologie (Stuttgart, Germany), 1991, Volume: 45, Issue:10

    Topics: Angiotensin II; Animals; Azepines; Hypoxia; Organ Culture Techniques; Perfusion; Platelet Activating Factor; Pulmonary Circulation; Rats; Triazoles; Vasoconstriction

1991
Cell adhesion by membrane-bound paf-acether.
    International immunology, 1991, Volume: 3, Issue:11

    Topics: Animals; Azepines; Calcimycin; Cell Adhesion; Diterpenes; Ginkgolides; Humans; In Vitro Techniques; Lactones; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Triazoles; Zymosan

1991
Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs.
    Prostaglandins, 1991, Volume: 42, Issue:5

    Topics: Administration, Oral; Analysis of Variance; Animals; Asthma; Azepines; Bronchial Hyperreactivity; Bronchoconstriction; Calcium; Eosinophils; Guinea Pigs; Lung; Male; Platelet Activating Factor; Triazoles

1991
Effect of platelet-activating factor on porcine pulmonary blood vessels in vitro.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 344, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Calcimycin; Diterpenes; Eicosanoids; Ginkgolides; In Vitro Techniques; Lactones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pulmonary Circulation; Radioimmunoassay; SRS-A; Swine; Thromboxane B2; Triazoles

1991
Mechanisms of platelet-activating factor-induced electrolyte transport in the rat jejunum.
    European journal of pharmacology, 1991, Jul-23, Volume: 200, Issue:1

    Topics: Animals; Arachidonic Acids; Azepines; Biological Transport, Active; Chlorides; Dinoprostone; Eicosanoic Acids; Electrophysiology; Female; Indomethacin; Jejunum; Platelet Activating Factor; Quinacrine; Rats; Triazoles

1991
B-cell activation and regulation of immunoglobulin synthesis by platelet activating factor.
    The Netherlands journal of medicine, 1991, Volume: 39, Issue:3-4

    Topics: Azepines; B-Lymphocytes; Calcium; Cell Differentiation; Cell Line; Inositol; Lymphocyte Activation; Phospholipid Ethers; Platelet Activating Factor; Receptors, Antigen, B-Cell; Triazoles

1991
Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat.
    Agents and actions, 1991, Volume: 34, Issue:1-2

    Topics: Acetates; Animals; Azepines; Colitis; Inflammation; Platelet Activating Factor; Polyunsaturated Alkamides; Pyridines; Rats; Rats, Inbred Strains; Triazoles

1991
Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig.
    Agents and actions, 1991, Volume: 34, Issue:1-2

    Topics: Animals; Aspirin; Azepines; Bronchial Diseases; Bronchoalveolar Lavage Fluid; Escherichia coli; Guinea Pigs; Lipopolysaccharides; Macrophages; Male; Neutrophils; Platelet Activating Factor; Pulmonary Edema; Pyrilamine; Respiratory Hypersensitivity; Triazoles

1991
Effects of platelet activating factor on rat platelets in vivo.
    European journal of pharmacology, 1991, Dec-17, Volume: 209, Issue:3

    Topics: Adenosine Diphosphate; Animals; Azepines; Blood Platelets; In Vitro Techniques; Leukocytes; Male; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Count; Pulmonary Embolism; Rats; Rats, Inbred Strains; Triazoles

1991
Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice.
    Prostaglandins, 1991, Volume: 42, Issue:6

    Topics: Administration, Inhalation; Anaphylaxis; Animals; Antigens; Asthma; Azepines; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; Triazoles

1991
Long time incubation of monocytic U 937 cells with LDL increases specific paf-acether binding and the cellular acetylhydrolase activity.
    Chemistry and physics of lipids, 1991, Volume: 59, Issue:3

    Topics: Acetylesterase; Azepines; Cell Line; Humans; Lipoproteins, LDL; Macrophages; Monocytes; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Triazoles

1991
Influence of aminophylline and ketotifen in comparison to the lipoxygenase inhibitors NDGA and esculetin and the PAF antagonists WEB 2170 [correction of 2107] and BN 52021 on endothelin-1 induced vaso- and bronchoconstriction.
    Prostaglandins, leukotrienes, and essential fatty acids, 1991, Volume: 44, Issue:3

    Topics: Aminophylline; Animals; Azepines; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Diterpenes; Endothelins; Ginkgolides; Guinea Pigs; Ketotifen; Lactones; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Platelet Activating Factor; Platelet Aggregation Inhibitors; Theophylline; Thromboxane B2; Triazoles; Umbelliferones; Vasoconstriction; Vasoconstrictor Agents

1991
Structure-activity studies on triazolothienodiazepine derivatives as platelet-activating factor antagonists.
    Chemical & pharmaceutical bulletin, 1991, Volume: 39, Issue:12

    Topics: Animals; Azepines; Blood Platelets; Guinea Pigs; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Activation; Structure-Activity Relationship; Triazoles

1991
Pharmacological activities of a novel thienodiazepine derivative as a platelet-activating factor antagonist. Effects on microvascular permeability, hypotension and nephrosis.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:12

    Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Endotoxins; Guinea Pigs; Male; Nephrosis; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Triazoles

1991
Protective effect of SR 27417, a novel PAF antagonist, on lethal anaphylactic and endotoxin-induced shock in mice.
    European journal of pharmacology, 1991, Dec-03, Volume: 205, Issue:3

    Topics: Anaphylaxis; Animals; Azepines; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Male; Mice; Mice, Inbred Strains; Ovalbumin; Platelet Activating Factor; Shock, Septic; Thiazoles; Triazoles

1991
Inhibition by the PAF antagonist WEB 2086 of PAF induced inositol-1,4,5-trisphosphate production in human platelets.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Adenosine Diphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Platelet Activating Factor; Thrombin; Triazoles

1991
Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Animals; Azepines; Diterpenes; Female; Gangliosides; Ginkgolides; In Vitro Techniques; Kidney; Kinetics; Lactones; Male; Perfusion; Platelet Activating Factor; Pyridines; Rabbits; Renal Circulation; Tachyphylaxis; Thiazoles; Time Factors; Triazoles

1991
Effect of the hetrazepinoic platelet-activating factor antagonist Bepafant (WEB 2170) in models of active and passive anaphylaxis in mice and guinea pigs.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Guinea Pigs; Lung; Male; Mice; Mice, Inbred Strains; Ovalbumin; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; Propranolol; Pyrilamine; Respiration; Triazoles

1991
Platelet-activating factor type activity in plasma from patients with septicemia and other diseases.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Adult; Animals; Azepines; Bacteremia; Blood Platelets; C-Reactive Protein; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Purpura, Thrombocytopenic; Rabbits; Reference Values; Triazoles

1991
Platelet activating factor (PAF) antagonists: development of a highly potent PAF antagonist, TCV-309.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21B

    Topics: Animals; Azepines; Humans; Isoquinolines; Molecular Structure; Niacinamide; Platelet Activating Factor; Pyridinium Compounds; Rabbits; Rats; Structure-Activity Relationship; Tetrahydroisoquinolines; Triazoles

1991
PAF antagonists inhibit monocrotaline-induced lung injury and pulmonary hypertension.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 71, Issue:6

    Topics: Animals; Azepines; Cardiomegaly; Hypertension, Pulmonary; Lung; Lung Injury; Male; Monocrotaline; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles

1991
Enterolobin induces rat paw oedema independently of PAF-acether.
    Memorias do Instituto Oswaldo Cruz, 1991, Volume: 86 Suppl 2

    Topics: Animals; Azepines; Dihydropyridines; Diterpenes; Edema; Ginkgolides; Lactones; Male; Plant Proteins; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles

1991
Characterization of platelet aggregation induced by the human melanoma cell line HMV-I: roles of heparin, plasma adhesive proteins, and tumor cell membrane proteins.
    Cancer research, 1991, Feb-15, Volume: 51, Issue:4

    Topics: Antibodies, Monoclonal; Azepines; Blood Coagulation Factors; Calcium; Cells, Cultured; Citrates; Citric Acid; Fibrinogen; Flow Cytometry; Heparin; In Vitro Techniques; Magnesium; Melanoma; Membrane Proteins; Microbial Collagenase; Neuraminidase; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombospondins; Triazoles; Trypsin

1991
Platelet-activating factor (PAF) receptor-mediated calcium mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells: studies with BN50739, a new PAF antagonist.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1

    Topics: Animals; Azepines; Calcium; Calcium Channel Blockers; Cells, Cultured; Gallic Acid; Hybrid Cells; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1991
[Platelet-activating factor (PAF) antagonists].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1991, Volume: 36, Issue:3

    Topics: Animals; Azepines; Binding, Competitive; Diterpenes; Furans; Ginkgolides; Humans; Lactones; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1991
Effects of platelet-activating factor on beta- and H2-receptor-mediated increase of myocardial contractile force in isolated perfused guinea pig hearts.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1991, Volume: 191, Issue:1

    Topics: Animals; Azepines; Coronary Circulation; Drug Interactions; Guanidines; Guinea Pigs; Heart Rate; Imidazoles; Impromidine; Isoproterenol; Myocardial Contraction; Platelet Activating Factor; Receptors, Adrenergic, beta; Receptors, Histamine H2; Triazoles

1991
Effect of BN 50739, a new platelet activating factor antagonist, on ischaemia induced ventricular arrhythmias in isolated working rat hearts.
    Cardiovascular research, 1991, Volume: 25, Issue:5

    Topics: Animals; Arrhythmias, Cardiac; Azepines; Coronary Disease; Dose-Response Relationship, Drug; Heart; Heart Ventricles; Male; Myocardial Reperfusion; Organ Culture Techniques; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles

1991
Activity of a novel thienodiazepine derivative as a platelet-activating factor antagonist in guinea pig lungs. Effects on platelet-activating factor and allergen induced eosinophil accumulation.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:3

    Topics: Aerosols; Animals; Azepines; Bronchoalveolar Lavage Fluid; Eosinophils; Guinea Pigs; Leukocyte Count; Lung; Male; Methylprednisolone; Platelet Activating Factor; Triazoles

1991
Survival of renal allografted dogs after limited therapy with cyclosporine and the PAF antagonist WEB 2170.
    Transplantation proceedings, 1991, Volume: 23, Issue:4

    Topics: Animals; Azepines; Cyclosporins; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Survival; Immunosuppressive Agents; Kidney Transplantation; Platelet Activating Factor; Triazoles

1991
Action of the racemate and the isomers of the platelet-activating factor antagonist bepafant (WEB 2170) after oral administration to guinea-pigs and rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:5

    Topics: Administration, Oral; Animals; Azepines; Blood Pressure; Dose-Response Relationship, Drug; Guinea Pigs; Male; Platelet Activating Factor; Pulmonary Ventilation; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship; Time Factors; Triazoles

1991
Platelet-leukocyte interaction in adhesion to endothelial cells induced by platelet-activating factor in vitro.
    British journal of pharmacology, 1991, Volume: 103, Issue:2

    Topics: Adenine; Animals; Azepines; Blood Platelets; Cell Adhesion; Diterpenes; Endothelium, Vascular; Female; Ginkgolides; Humans; In Vitro Techniques; Lactones; Leukocytes; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Pregnancy; Rabbits; Thiazoles; Triazoles; Umbilical Veins

1991
Biosynthesis of platelet activating factor (PAF) by an osteosarcoma cell line (UMR 106).
    Biochemical Society transactions, 1991, Volume: 19, Issue:2

    Topics: Animals; Azepines; Cell Line; Enzyme Activation; Kinetics; Osteosarcoma; Phospholipases A; Platelet Activating Factor; Platelet Aggregation; Rats; Sarcoma, Experimental; Triazoles

1991
Thrombin-induced leukopenia and thrombocytopenia are attenuated by PAF antagonist WEB 2086.
    The Journal of laboratory and clinical medicine, 1991, Volume: 117, Issue:4

    Topics: Animals; Azepines; Carbon Dioxide; Cell Adhesion; Leukocyte Count; Leukopenia; Platelet Activating Factor; Sheep; Thrombin; Thrombocytopenia; Thromboxane B2; Triazoles

1991
A triazolodiazepine platelet activating factor receptor antagonist (WEB 2086) reduces pulmonary dysfunction during endotoxin shock in swine.
    The Journal of trauma, 1991, Volume: 31, Issue:7

    Topics: Animals; Azepines; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; Endotoxins; Leukocyte Count; Lung; Platelet Activating Factor; Pulmonary Artery; Pulmonary Circulation; Pulmonary Gas Exchange; Salmonella; Shock, Septic; Swine; Swine, Miniature; Tissue Plasminogen Activator; Triazoles; Vascular Resistance

1991
Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin.
    British journal of industrial medicine, 1991, Volume: 48, Issue:9

    Topics: Aerosols; Airway Obstruction; Animals; Azepines; Dust; Edema; Endotoxins; Gossypium; Guinea Pigs; Male; Platelet Activating Factor; Respiration Disorders; Triazoles

1991
Sustained effects of platelet-activating factor infusion in piglets.
    Pediatric research, 1991, Volume: 30, Issue:3

    Topics: Animals; Animals, Newborn; Azepines; Female; Hypoxia; Infusions, Intravenous; Male; Platelet Activating Factor; Pulmonary Circulation; Quinolinium Compounds; Swine; Triazoles; Vasoconstriction

1991
The role of platelet activating factor in airway inflammation, airway hyperresponsiveness, and pulmonary function in monkeys.
    Annals of the New York Academy of Sciences, 1991, Volume: 629

    Topics: Aerosols; Animals; Antigens; Azepines; Bronchoconstriction; Lung; Macaca fascicularis; Male; Methacholine Chloride; Neutrophils; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System; Triazoles

1991
Intraperitoneal injection of human recombinant neutrophil-activating factor/interleukin 8 (hrNAF/IL-8) produces a T cell and eosinophil infiltrate in the guinea pig lung. Effect of PAF antagonist WEB2086.
    Annals of the New York Academy of Sciences, 1991, Volume: 629

    Topics: Animals; Azepines; Eosinophils; Guinea Pigs; Humans; Injections, Intraperitoneal; Interleukin-8; Kinetics; Lung; Platelet Activating Factor; Pulmonary Alveoli; Recombinant Proteins; Serum Albumin, Bovine; T-Lymphocytes; Triazoles

1991
The involvement of platelet-activating factor in thrombocytopenia and follicular rupture during gonadotropin-induced superovulation in immature rats.
    Endocrinology, 1991, Volume: 129, Issue:6

    Topics: Animals; Azepines; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Indomethacin; Ovulation; Ovulation Induction; Platelet Activating Factor; Platelet Activation; Platelet Count; Rats; Rats, Inbred Strains; Superovulation; Thrombocytopenia; Triazoles; Vena Cava, Inferior

1991
Inhibition of active anaphylaxis in mice and guinea pigs by the new hetrazepinoic PAF antagonist bepafant (WEB 2170).
    European journal of pharmacology, 1991, Jun-25, Volume: 199, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Bronchoconstriction; Guinea Pigs; Immunization; Male; Mice; Ovalbumin; Platelet Activating Factor; Propranolol; Pulmonary Ventilation; Pyrilamine; Triazoles

1991
Inhibition of cyclic flow variations and reocclusion after thrombolysis in dogs by a novel antagonist of platelet-activating factor.
    Journal of the American College of Cardiology, 1991, Volume: 18, Issue:7

    Topics: Administration, Oral; Animals; Benzodiazepines; Bleeding Time; Blood Coagulation; Blood Flow Velocity; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Therapy, Combination; Hemodynamics; Partial Thromboplastin Time; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Prothrombin Time; Recurrence; Tissue Plasminogen Activator; Triazolam; Triazoles

1991
PAF-induced conjunctivitis in the rabbit is mediated by peptido-leukotrienes.
    Journal of ocular pharmacology, 1990,Fall, Volume: 6, Issue:3

    Topics: Animals; Azepines; Conjunctiva; Conjunctivitis; Cyclooxygenase Inhibitors; Dicarboxylic Acids; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indomethacin; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; Second Messenger Systems; Tetrazoles; Thiazoles; Thienopyridines; Triazoles

1990
PAF receptors in guinea-pig and human lung.
    Agents and actions. Supplements, 1990, Volume: 31

    Topics: Animals; Asthma; Autoradiography; Azepines; Bronchi; Guinea Pigs; Humans; In Vitro Techniques; Lung; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Values; Tissue Distribution; Trachea; Triazoles

1990
Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors.
    Prostaglandins, 1990, Volume: 40, Issue:6

    Topics: Animals; Azepines; Binding, Competitive; Blood Platelets; Brain; Diazepam; Humans; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, GABA-A; Triazoles

1990
PAF-acether-antagonist WEB 2086 for treatment of chronic idiopathic thrombocytopenia.
    Lancet (London, England), 1990, Jul-21, Volume: 336, Issue:8708

    Topics: Azepines; Chronic Disease; Drug Evaluation; Humans; Platelet Activating Factor; Thrombocytopenia; Triazoles

1990
Recovery of postischemic brain metabolism and function following treatment with a free radical scavenger and platelet-activating factor antagonists.
    Journal of neurochemistry, 1991, Volume: 56, Issue:1

    Topics: Adenosine Monophosphate; Animals; Azepines; Brain; Creatine; Dimethyl Sulfoxide; Dogs; Electroencephalography; Evoked Potentials, Auditory; Free Radical Scavengers; Glucose; Glycogen; Hydrogen-Ion Concentration; Ischemic Attack, Transient; Kinetics; Oxygen; Phosphocreatine; Platelet Activating Factor; Thienopyridines; Triazoles; Vascular Resistance

1991
Multiparametric flow cytometry of the modulation of tumor cell membrane permeability by developmental antitumor ether lipid SRI 62-834 in EMT6 mouse mammary tumor and HL-60 human promyelocytic leukemia cells.
    Cancer research, 1991, Feb-01, Volume: 51, Issue:3

    Topics: Animals; Antineoplastic Agents; Azepines; Cell Division; Cell Membrane Permeability; Flow Cytometry; Furans; Humans; Hydrogen-Ion Concentration; Leukemia, Promyelocytic, Acute; Mammary Neoplasms, Animal; Mice; Phospholipid Ethers; Platelet Activating Factor; Time Factors; Triazoles; Tumor Cells, Cultured

1991
Platelet-activating factor (PAF) antagonist WEB 2086 does not modulate the cytotoxicity of PAF or antitumour alkyl lysophospholipids ET-18-O-methyl and SRI 62-834 in HL-60 promyelocytic leukaemia cells.
    Biochemical pharmacology, 1991, Jan-15, Volume: 41, Issue:2

    Topics: Antineoplastic Agents; Azepines; Calcium; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Furans; Humans; Leukemia, Promyelocytic, Acute; Phospholipid Ethers; Platelet Activating Factor; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured

1991
The involvement of platelet-activating factor in hyperacute xenogeneic rejection and its modulation by the PAF-antagonist WEB 2086BS.
    Transplantation proceedings, 1991, Volume: 23, Issue:1 Pt 1

    Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Azepines; Female; Graft Rejection; Hemoperfusion; Humans; Kidney Transplantation; Male; Platelet Activating Factor; Swine; Thromboxane B2; Transplantation, Heterologous; Triazoles

1991
Effects of various barriers on platelet-activating factor-induced neutrophil chemotaxis.
    The Journal of allergy and clinical immunology, 1991, Volume: 87, Issue:2

    Topics: Azepines; Cell Line; Cell Separation; Cells, Cultured; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Endothelium, Vascular; Epithelium; Filtration; Humans; Microscopy, Electron; Neutrophils; Platelet Activating Factor; Time Factors; Triazoles

1991
Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:3

    Topics: Animals; Azepines; Benzodiazepines; Blood Platelets; Bronchoconstriction; Chemical Phenomena; Chemistry; Dogs; Guinea Pigs; Male; Molecular Conformation; Molecular Structure; Platelet Activating Factor; Structure-Activity Relationship; Thiophenes; Triazoles

1991
Protective effects of specific platelet-activating factor receptor antagonists in experimental glomerulonephritis.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3

    Topics: Animals; Azepines; Glomerular Filtration Rate; Glomerulonephritis; Hemodynamics; Kidney; Male; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles

1991
Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:4

    Topics: Animals; Azepines; Guinea Pigs; Indicators and Reagents; Lung; Magnetic Resonance Spectroscopy; Molecular Structure; Platelet Activating Factor; Structure-Activity Relationship; Thiophenes; Triazoles

1991
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
    Biochemical and biophysical research communications, 1991, Apr-30, Volume: 176, Issue:2

    Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Male; Metabolic Clearance Rate; Methylprednisolone; Piperazines; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Ticlopidine; Triazoles

1991
Stimulation of neutrophil adherence to vascular endothelial cells by histamine and thrombin and its inhibition by PAF antagonists and dexamethasone.
    British journal of pharmacology, 1991, Volume: 102, Issue:1

    Topics: Animals; Azepines; Cell Adhesion; Cells, Cultured; Dexamethasone; Endothelium, Vascular; Furans; Histamine; Humans; In Vitro Techniques; Indomethacin; Male; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thrombin; Triazoles

1991
Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage.
    The American review of respiratory disease, 1991, Volume: 143, Issue:6

    Topics: Administration, Inhalation; Animals; Azepines; Bronchi; Bronchoconstriction; Capillary Permeability; Evans Blue; Guinea Pigs; Lung Compliance; Platelet Activating Factor; Respiratory System; Time Factors; Triazoles

1991
Characterization of platelet-activating factor-induced elevation of cytosolic free-calcium level in neurohybrid NCB-20 cells.
    Neuroscience, 1991, Volume: 41, Issue:1

    Topics: Animals; Azepines; Calcium; Calcium Channel Blockers; Cerebral Cortex; Cricetinae; Cricetulus; Cytosol; Diterpenes; Gallic Acid; Ginkgolides; Hybrid Cells; Lactones; Mice; Neuroblastoma; Platelet Activating Factor; Quinolinium Compounds; Triazoles

1991
Allergen-induced bronchospasm in passively sensitized guinea pigs: influence of new substances in comparison to reference compounds.
    Agents and actions, 1991, Volume: 32, Issue:1-2

    Topics: Acrylates; Allergens; Animals; Azepines; Benzoates; Bronchial Spasm; Disease Models, Animal; Guinea Pigs; Immunization, Passive; Male; Ovalbumin; Phospholipases A; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles

1991
[Involvement of platelet activating factor (PAF) in ovalbumin antigen-induced late asthmatic response and increase of airway hyperresponsiveness in a guinea pig experimental model of asthma].
    Arerugi = [Allergy], 1991, Volume: 40, Issue:2

    Topics: Airway Resistance; Animals; Asthma; Azepines; Disease Models, Animal; Guinea Pigs; Hypersensitivity, Delayed; Male; Ovalbumin; Platelet Activating Factor; Triazoles

1991
Platelet-activating factor stimulates a rapid accumulation of inositol (1,4,5)trisphosphate in guinea pig eosinophils: relationship to calcium mobilization and degranulation.
    The Journal of allergy and clinical immunology, 1991, Volume: 88, Issue:1

    Topics: Animals; Azepines; Calcium; Cell Separation; Cytoplasmic Granules; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Inositol 1,4,5-Trisphosphate; Male; Peritoneal Cavity; Platelet Activating Factor; Second Messenger Systems; Stimulation, Chemical; Time Factors; Triazoles

1991
Bombesin-induced bronchoconstriction in the guinea pig: mode of action.
    The Journal of pharmacology and experimental therapeutics, 1991, Jul-01, Volume: 258, Issue:1

    Topics: Animals; Azepines; Blood Pressure; Bombesin; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Male; Muscle, Smooth; Platelet Activating Factor; Pyrilamine; Trachea; Triazoles

1991
Bradykinin-induced plasma exudation in guinea-pig airways: involvement of platelet activating factor.
    British journal of pharmacology, 1990, Volume: 101, Issue:3

    Topics: Animals; Azepines; Bradykinin; Edema; Evans Blue; Exudates and Transudates; Guinea Pigs; Male; Plasma; Platelet Activating Factor; Respiratory Physiological Phenomena; Respiratory System; Triazoles

1990
Effects of a novel PAF antagonist, E6123, on PAF-induced biological responses.
    Agents and actions. Supplements, 1990, Volume: 31

    Topics: Animals; Azepines; Blood Platelets; Bronchoconstriction; Bronchoconstrictor Agents; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Platelet Activating Factor; Platelet Aggregation; Triazoles

1990
Effects of a novel PAF antagonist, E6123, on passive anaphylaxis.
    Agents and actions. Supplements, 1990, Volume: 31

    Topics: Anaphylaxis; Animals; Antigens; Azepines; Bronchoconstriction; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Triazoles

1990
Eosinophil accumulation in the rat pleural cavity after mast cell stimulation with compound 48/80 involves protein synthesis and is selectively suppressed by dexamethasone.
    International archives of allergy and applied immunology, 1990, Volume: 92, Issue:4

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Cycloheximide; Dexamethasone; Eosinophils; Female; Leukocyte Count; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Pleura; Protein Biosynthesis; Rats; Rats, Inbred Strains; Triazoles

1990
Pharmacological activities of a novel thienodiazepine derivative as a platelet-activating factor antagonist.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:11

    Topics: Administration, Oral; Animals; Azepines; Blood Platelets; Bronchoconstriction; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Injections, Intravenous; Mice; Mice, Inbred ICR; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Species Specificity; Triazoles

1990
Pharmacological actions of Y-24180: I. A potent and specific antagonist of platelet-activating factor.
    Prostaglandins, 1990, Volume: 40, Issue:6

    Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Bronchi; Female; Guinea Pigs; Hematocrit; Male; Mice; Mice, Inbred ICR; Platelet Activating Factor; Rats; Rats, Inbred Lew; Triazoles

1990
Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption.
    Advances in experimental medicine and biology, 1990, Volume: 277

    Topics: Animals; Azepines; Brain; Cerebrovascular Circulation; Diterpenes; Ginkgolides; Indomethacin; Lactones; Male; Oxygen Consumption; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles

1990
Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224.
    The American review of respiratory disease, 1990, Volume: 142, Issue:3

    Topics: Albumins; Anaphylaxis; Animals; Asthma; Azepines; Betamethasone; Bronchoalveolar Lavage Fluid; Cell Count; Eosinophils; Guinea Pigs; Histamine; Immunization; Indomethacin; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung; Male; Naphthyridines; Ovalbumin; Platelet Activating Factor; Pyrazoles; Thromboxanes; Triazoles

1990
Tumor necrosis factor (TNF) and endotoxin prime effects of PAF in vivo.
    Journal of lipid mediators, 1990, Volume: 2 Suppl

    Topics: Animals; Azepines; Drug Interactions; Endotoxins; Gastrointestinal Transit; Mice; Platelet Activating Factor; Shock, Septic; Triazoles; Tumor Necrosis Factor-alpha

1990
Effects of platelet activating factor antagonists on arachidonic acid-induced platelet aggregation and TXA2 formation.
    Prostaglandins, leukotrienes, and essential fatty acids, 1990, Volume: 41, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Azepines; Blood Platelets; Diterpenes; Ginkgolides; Imidazoles; In Vitro Techniques; Lactones; Naphthalenes; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Triazoles

1990
Role of spermatozoal platelet-activating factor in fertilization.
    Prostaglandins, 1990, Volume: 39, Issue:1

    Topics: Animals; Arachidonic Acids; Azepines; Chromatography, High Pressure Liquid; Female; Fertilization; Fertilization in Vitro; Humans; Leukotriene B4; Lipoxygenase; Male; Mice; Platelet Activating Factor; Pregnancy; Prostaglandins F; Sperm Motility; Spermatozoa; Thromboxane B2; Triazines; Triazoles

1990
1,25-(OH)2 vitamin D-3 enhances Paf-stimulated calcium mobilization in U937 cells by expression of specific Paf binding sites.
    Biochimica et biophysica acta, 1990, Feb-19, Volume: 1051, Issue:2

    Topics: Animals; Azepines; Calcitriol; Calcium; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Binding; Receptors, Cell Surface; Receptors, G-Protein-Coupled; SRS-A; Triazines; Triazoles

1990
Platelet activating factor stimulates cyclo-oxygenase activity in guinea pig eosinophils. Concerted biosynthesis of thromboxane A2 and E-series prostaglandins.
    Journal of immunology (Baltimore, Md. : 1950), 1990, May-01, Volume: 144, Issue:9

    Topics: Animals; Azepines; Calcimycin; Calcium; Complement C5a; Cyclooxygenase Inhibitors; Enzyme Activation; Eosinophils; Flurbiprofen; Guinea Pigs; Imidazoles; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Triazines; Triazoles

1990
[Characterization of platelet-activating factor (PAF)-receptors in neutrophilic and eosinophilic granulocytes].
    Pneumologie (Stuttgart, Germany), 1990, Volume: 44 Suppl 1

    Topics: Azepines; Cell Degranulation; Eosinophils; Humans; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1990
Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence.
    The American journal of physiology, 1990, Volume: 259, Issue:2 Pt 1

    Topics: Animals; Azepines; Cats; Cell Adhesion; Diterpenes; Ginkgolides; Intestine, Small; Ischemia; Lactones; Leukocytes; Mesenteric Arteries; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Values; Reperfusion; Triazoles

1990
Characterization of receptors for platelet-activating factor in guinea pig lung membranes.
    American journal of respiratory cell and molecular biology, 1990, Volume: 3, Issue:3

    Topics: Animals; Azepines; Cell Membrane; Female; Guinea Pigs; Kinetics; Lung; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles

1990
Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular species.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Oct-15, Volume: 145, Issue:8

    Topics: Azepines; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; In Vitro Techniques; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Time Factors; Triazoles

1990
[Protective effect of a platelet activating factor antagonist in experimental liver injury].
    Zhonghua yi xue za zhi, 1990, Volume: 70, Issue:7

    Topics: Animals; Azepines; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Liver; Malondialdehyde; Peroxidase; Platelet Activating Factor; Rats; Rats, Inbred Strains; Superoxide Dismutase; Triazoles

1990
Effect of platelet-activating factor receptor antagonism on endotoxin-induced lung dysfunction in awake sheep.
    The American review of respiratory disease, 1990, Volume: 142, Issue:6 Pt 1

    Topics: Animals; Azepines; Consciousness; Cyclooxygenase Inhibitors; Endotoxins; Escherichia coli; Platelet Activating Factor; Platelet Membrane Glycoproteins; Premedication; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Distress Syndrome; Sheep; Thromboxane-A Synthase; Triazoles

1990
Influence of SK&F 95587 and BN 50730 on bronchoconstrictor responses in the cat.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Azepines; Bronchoconstriction; Cats; Dose-Response Relationship, Drug; Female; Lung; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Prostaglandin; Receptors, Thromboxane; Respiration; Sulfonamides; Tetrazoles; Thienopyridines; Time Factors; Triazoles

1990
The relationship between neutrophils and increased microvascular permeability in a model of myocardial ischaemia and reperfusion in the rabbit.
    British journal of pharmacology, 1990, Volume: 100, Issue:4

    Topics: Anesthesia; Animals; Antibodies, Monoclonal; Azepines; Blood Pressure; Blood Proteins; Capillary Permeability; Coronary Disease; Heart Rate; In Vitro Techniques; Indium Radioisotopes; Iodine Radioisotopes; Male; Mechlorethamine; Models, Biological; Myocardial Reperfusion Injury; Neutrophils; Platelet Activating Factor; Rabbits; Triazoles

1990
Platelet activating factor (PAF) and tumor necrosis factor-alpha (TNF alpha) interactions in endotoxemic shock: studies with BN 50739, a novel PAF antagonist.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:1

    Topics: Animals; Azepines; Blood Cells; Hemodynamics; Humans; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Recombinant Proteins; Shock, Septic; Thromboxanes; Triazoles; Tumor Necrosis Factor-alpha

1990
Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits.
    Stroke, 1990, Volume: 21, Issue:10

    Topics: Animals; Azepines; Cerebrovascular Disorders; Disease Models, Animal; Platelet Activating Factor; Rabbits; Reference Values; Regional Blood Flow; Spinal Cord; Spinal Cord Injuries; Triazoles

1990
A factor in serum lowers resistance and opens tight junctions of MDCK cells.
    The American journal of physiology, 1990, Volume: 259, Issue:4 Pt 1

    Topics: Animals; Azepines; Blood; Cell Line; Chromatography, Gel; Complement C3a; Complement C5a; Culture Media; Dogs; Humans; Inflammation; Intercellular Junctions; Kidney; Kinetics; Molecular Weight; Platelet Activating Factor; Serum Albumin; Triazoles

1990
Use of WEB 2086 and WEB 2170 as platelet-activating factor antagonists.
    Methods in enzymology, 1990, Volume: 187

    Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Lung; Methods; Molecular Structure; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Rabbits; Triazoles

1990
Pulmonary hypertension after heparin-protamine: roles of left-sided infusion, histamine, and platelet-activating factor.
    Anesthesia and analgesia, 1990, Volume: 71, Issue:6

    Topics: Animals; Azepines; Clemastine; Hemodynamics; Heparin Antagonists; Hypertension, Pulmonary; Platelet Activating Factor; Protamines; Ranitidine; Swine; Triazoles

1990
IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators.
    The American review of respiratory disease, 1990, Volume: 142, Issue:5

    Topics: Acute Disease; Animals; Azepines; Bronchoconstriction; Dicarboxylic Acids; Dose-Response Relationship, Drug; Furans; Guinea Pigs; Immunization; Immunoglobulin G; Indoles; Lipids; Lung; Male; Ovalbumin; Phenylcarbamates; Piroxicam; Platelet Activating Factor; Propranolol; Pyrilamine; Respiratory Hypersensitivity; SRS-A; Sulfonamides; Tosyl Compounds; Triazoles

1990
Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists.
    The American review of respiratory disease, 1990, Volume: 142, Issue:5

    Topics: Animals; Azepines; Blood Pressure; Bronchi; Bronchoalveolar Lavage Fluid; Dexamethasone; Enzyme Inhibitors; Guinea Pigs; Humans; Indazoles; Indomethacin; Lung; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Pressure; Propranolol; Pyrilamine; SRS-A; Trachea; Triazoles

1990
Platelet-activating factor: evidence against a role in hypoxic pulmonary vasoconstriction.
    Critical care medicine, 1990, Volume: 18, Issue:12

    Topics: Animals; Azepines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Injections, Intravenous; Male; Platelet Activating Factor; Pulmonary Circulation; Swine; Triazoles; Vascular Resistance; Vasoconstriction

1990
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
    Cancer research, 1990, Dec-01, Volume: 50, Issue:23

    Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil

1990
Contribution of platelet activating factor to hemodynamic and sympathetic responses to bacterial endotoxin in conscious rats.
    Circulatory shock, 1990, Volume: 32, Issue:2

    Topics: Animals; Azepines; Blood Glucose; Blood Pressure; Catecholamines; Endotoxins; Heart Rate; Hemodynamics; Lactates; Lactic Acid; Male; Platelet Activating Factor; Rats; Shock, Septic; Sympathetic Nervous System; Triazoles

1990
Alterations in endocardial vascular resistance after reperfusion in a low flow, high demand model of ischemia: effects of dipyridamole and WEB-2086, a platelet-activating factor antagonist.
    Journal of the American College of Cardiology, 1990, Volume: 16, Issue:7

    Topics: Adenosine; Animals; Azepines; Coronary Vessels; Dipyridamole; Dogs; Hemodynamics; Myocardial Reperfusion Injury; Platelet Activating Factor; Triazoles; Vascular Resistance

1990
Intrapulmonary tumor necrosis factor triggers local platelet-activating factor production in rat immune complex alveolitis.
    Laboratory investigation; a journal of technical methods and pathology, 1990, Volume: 63, Issue:6

    Topics: Alveolitis, Extrinsic Allergic; Animals; Antibodies; Antigen-Antibody Complex; Azepines; Furans; Immunoglobulin G; Kinetics; Lung; Macrophages; Male; Neutrophils; Platelet Activating Factor; Rats; Triazoles; Tumor Necrosis Factor-alpha

1990
Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3

    Topics: Administration, Oral; Animals; Azepines; Bronchoconstriction; Capillary Permeability; Cell Aggregation; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Hypotension; Infusions, Intravenous; Injections, Intradermal; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Skin; Time Factors; Triazoles

1990
Alterations in regional blood flow in rats following sensitization to the nematode Nippostrongylus brasiliensis: effects of PAF antagonists.
    British journal of pharmacology, 1990, Volume: 101, Issue:1

    Topics: Animals; Anthelmintics; Azepines; Blood Pressure; Cardiac Output; Diterpenes; Ginkgolides; Heart Rate; Immunization; Injections, Intraperitoneal; Lactones; Liver Circulation; Male; Microspheres; Nippostrongylus; Platelet Activating Factor; Rats; Rats, Inbred Strains; Regional Blood Flow; Submandibular Gland; Triazoles; Vascular Resistance

1990
Antagonism of endotoxin-induced disruption of equine gastrointestinal motility with the platelet-activating factor antagonist WEB 2086.
    Journal of veterinary pharmacology and therapeutics, 1990, Volume: 13, Issue:4

    Topics: Animals; Azepines; Endotoxins; Gastrointestinal Motility; Heart Rate; Hematocrit; Horses; Leukocyte Count; Male; Muscle Contraction; Platelet Activating Factor; Stomach; Triazoles

1990
Relaxations of guinea-pig isolated trachea induced by platelet-activating factor are epithelial-dependent and are antagonised by WEB 2086.
    European journal of pharmacology, 1990, Sep-21, Volume: 186, Issue:2-3

    Topics: Albuterol; Animals; Azepines; Epithelium; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Platelet Activating Factor; Trachea; Triazoles

1990
Beneficial effect of a platelet-activating factor antagonist, WEB 2086, on endotoxin-induced lung injury.
    The American journal of physiology, 1990, Volume: 258, Issue:1 Pt 2

    Topics: Animals; Azepines; Dose-Response Relationship, Drug; Endotoxins; Glutathione; Glutathione Disulfide; In Vitro Techniques; Lung; Male; Permeability; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serum Albumin, Bovine; Time Factors; Triazines; Triazoles

1990
Endogenous platelet activating factor does not modulate blood flow and metabolism in normal rat brain.
    Stroke, 1990, Volume: 21, Issue:3

    Topics: Animals; Azepines; Blood Pressure; Brain; Cerebrovascular Circulation; Diterpenes; Ginkgolides; Indomethacin; Lactones; Male; Oxygen; Platelet Activating Factor; Rats; Rats, Inbred Strains; Reference Values; Triazines; Triazoles

1990
The action of platelet activating factor and its antagonism by WEB 2086 on human isolated airways.
    The European respiratory journal, 1990, Volume: 3, Issue:1

    Topics: Azepines; Bronchi; Histamine; Humans; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Triazines; Triazoles

1990
Failure of platelet-activating factor (PAF-acether) to induce decidualization in mice and failure of antagonists of PAF to inhibit implantation.
    Journal of reproduction and fertility, 1990, Volume: 88, Issue:1

    Topics: Animals; Azepines; Decidua; Diterpenes; Embryo Implantation; Estradiol; Female; Ginkgolides; Lactones; Mice; Mice, Inbred Strains; Ovariectomy; Phospholipid Ethers; Platelet Activating Factor; Pregnancy; Progesterone; Triazines; Triazoles

1990
The effects of activated eosinophils and neutrophils on guinea pig airway epithelium in vitro.
    American journal of respiratory cell and molecular biology, 1990, Volume: 2, Issue:4

    Topics: Animals; Azepines; Catalase; Cell Survival; Cilia; Eosinophils; Epithelium; Guinea Pigs; Male; Neutrophils; Peritoneal Cavity; Platelet Activating Factor; Trachea; Triazines; Triazoles

1990
Platelet activating factor and sheep platelets: a sensitive new bioassay.
    Thrombosis research, 1990, Feb-15, Volume: 57, Issue:4

    Topics: Adenosine Diphosphate; Alprazolam; Animals; Azepines; Biological Assay; Blood Platelets; Cell Separation; Furans; Platelet Activating Factor; Platelet Aggregation; Serotonin; Sheep; Thrombin; Triazines; Triazoles

1990
Prevention of non-specific airway hyperreactivity after allergen challenge in guinea-pigs by the PAF receptor antagonist SDZ 64-412.
    British journal of pharmacology, 1990, Volume: 99, Issue:2

    Topics: Allergens; Animals; Azepines; Bronchi; Bronchoalveolar Lavage Fluid; Eosinophils; Guinea Pigs; Histamine; Hypersensitivity; In Vitro Techniques; Isoquinolines; Male; Methylprednisolone; Platelet Activating Factor; Triazines; Triazoles; Vagotomy; Vagus Nerve

1990
Differential inhibition by two hetrazepine PAF antagonists of acute inflammation in the mouse.
    British journal of pharmacology, 1990, Volume: 99, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Carrageenan; Dose-Response Relationship, Drug; Edema; Exudates and Transudates; Female; Leukocyte Count; Male; Mice; Platelet Activating Factor; Pleurisy; Serotonin; Triazines; Triazoles

1990
Inhibition of neutrophil and eosinophil chemotactic responses to PAF by the PAF-antagonists WEB-2086, L-652,731, and SRI-63441.
    Journal of leukocyte biology, 1990, Volume: 47, Issue:5

    Topics: Azepines; Chemotaxis; Complement C5; Eosinophils; Furans; Humans; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Quinolinium Compounds; Triazoles

1990
PAF potentiates protamine-induced lung edema: role of pulmonary venoconstriction.
    Journal of applied physiology (Bethesda, Md. : 1985), 1990, Volume: 68, Issue:3

    Topics: Animals; Azepines; Drug Synergism; In Vitro Techniques; Male; Neutrophils; Platelet Activating Factor; Protamines; Pulmonary Circulation; Pulmonary Edema; Rats; Rats, Inbred Strains; Triazoles; Vasoconstriction

1990
Platelet activating factor and one-kidney, one clip hypertension.
    Hypertension (Dallas, Tex. : 1979), 1990, Volume: 15, Issue:6 Pt 1

    Topics: Animals; Azepines; Blood Platelets; Blood Pressure; Hypertension, Renal; Male; Platelet Activating Factor; Rats; Rats, Inbred Strains; Renal Artery; Serotonin; Sodium; Triazoles

1990
Pharmacologic profile of BN 50739, a new PAF antagonist in vitro and in vivo.
    Prostaglandins, 1990, Volume: 39, Issue:5

    Topics: Animals; Azepines; Blood Platelets; Hypotension; In Vitro Techniques; Male; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Serotonin; Triazoles

1990
Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G.
    The American journal of physiology, 1990, Volume: 258, Issue:6 Pt 1

    Topics: Amino Acid Sequence; Aspirin; Azepines; Blood Platelets; Cathepsin G; Cathepsins; Complement C5a; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Pancreatic Elastase; Platelet Activating Factor; Platelet Activation; Protease Inhibitors; Recombinant Proteins; Serine Endopeptidases; Serotonin; Triazoles

1990
Search for mediators of the lipogenic effects of tumor necrosis factor: potential role for interleukin 6.
    Cancer research, 1990, Jul-15, Volume: 50, Issue:14

    Topics: Animals; Aspirin; Azepines; Cholesterol; Fatty Acids; Ibuprofen; Interleukin-6; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Oleic Acid; Oleic Acids; Pentoxifylline; Phenoxybenzamine; Platelet Activating Factor; Propranolol; Rats; Rats, Inbred Strains; Reference Values; Triazoles; Triglycerides; Tumor Necrosis Factor-alpha

1990
Platelet-activating factor and progressive brain damage following focal brain injury.
    Journal of neurosurgery, 1990, Volume: 73, Issue:2

    Topics: Animals; Azepines; Blood-Brain Barrier; Body Water; Brain Injuries; Cerebral Cortex; Male; Neurons; Neutrophils; Permeability; Platelet Activating Factor; Rats; Rats, Inbred Strains; Regional Blood Flow; Triazoles

1990
Early and late tracheobronchial plasma exudation by platelet-activating factor administered to the airway mucosal surface in guinea pigs: effects of WEB 2086 and enprofylline.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1

    Topics: Animals; Azepines; Bronchi; Capillary Permeability; Guinea Pigs; Male; Mucous Membrane; Platelet Activating Factor; Trachea; Triazoles; Xanthines

1990
Platelet-activating factor mediates gastric damage induced by hemorrhagic shock.
    The American journal of physiology, 1990, Volume: 259, Issue:1 Pt 1

    Topics: Animals; Azepines; Diterpenes; Gastric Mucosa; Ginkgolides; Lactones; Male; Membrane Potentials; Muscle, Smooth; Platelet Activating Factor; Rats; Rats, Inbred Strains; Regional Blood Flow; Shock, Hemorrhagic; Stomach; Triazoles

1990
The booster injection of antigen during active sensitization of guinea-pig modifies the anti-anaphylactic activity of the PAF antagonist WEB 2086.
    British journal of pharmacology, 1990, Volume: 100, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Blood Cell Count; Bronchi; Enzyme-Linked Immunosorbent Assay; Guinea Pigs; Histamine; Immunization, Secondary; Immunoglobulin G; Lung; Ovalbumin; Platelet Activating Factor; Radioimmunoassay; Spectrometry, Fluorescence; Thromboxane B2; Triazoles

1990
Effects of the PAF antagonist WEB 2086 on PAF-induced physiologic alterations and on IgE anaphylaxis in the rabbit.
    The American review of respiratory disease, 1990, Volume: 142, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Bronchial Spasm; Hypotension; Immunoglobulin E; Leukopenia; Lung; Platelet Activating Factor; Rabbits; Thrombocytopenia; Triazoles

1990
Failure of the platelet-activating-factor antagonist WEB 2086 BS for treatment of chronic autoimmune thrombocytopenia.
    Blut, 1990, Volume: 61, Issue:1

    Topics: Adult; Aged; Autoimmune Diseases; Azepines; Chronic Disease; Drug Evaluation; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Prospective Studies; Thrombocytopenia; Triazoles

1990
Prolongation of rat heart allograft survival using low-dose cyclosporine and PAF antagonist WEB 2170.
    Transplantation proceedings, 1990, Volume: 22, Issue:4

    Topics: Animals; Azepines; Cyclosporins; Graft Rejection; Graft Survival; Heart Transplantation; Platelet Activating Factor; Rats; Transplantation, Heterotopic; Transplantation, Homologous; Triazoles

1990
Effects of a PAF-antagonist (WEB 2086) on hyperacute xenogeneic rejection in ex vivo perfused kidneys.
    Transplantation proceedings, 1990, Volume: 22, Issue:4

    Topics: Animals; Azepines; Female; Graft Rejection; Hemagglutination Tests; Humans; Kidney Transplantation; Male; Perfusion; Platelet Activating Factor; Swine; Transplantation, Heterologous; Triazoles

1990
Hypoxia causes ischemic bowel necrosis in rats: the role of platelet-activating factor (PAF-acether).
    Gastroenterology, 1990, Volume: 99, Issue:4

    Topics: Animals; Azepines; Enterocolitis, Pseudomembranous; Hypoxia; Intestine, Small; Male; Platelet Activating Factor; Quinolinium Compounds; Rats; Rats, Inbred Strains; Triazoles

1990
Protective effect of BN 50739, a new platelet-activating factor antagonist, in endotoxin-treated rabbits.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:3

    Topics: Animals; Azepines; Blood Cell Count; Endotoxins; Leukopenia; Male; Platelet Activating Factor; Rabbits; Thrombocytopenia; Thromboxane B2; Triazoles

1990
Biological responses to liposome-encapsulated hemoglobin (LEH) are improved by a PAF antagonist.
    Circulatory shock, 1990, Volume: 31, Issue:4

    Topics: Animals; Azepines; Blood Substitutes; Chemical Phenomena; Chemistry, Physical; Drug Interactions; Hemodynamics; Hemoglobins; Leukocyte Count; Liposomes; Male; Oxygen; Phosphatidylcholines; Platelet Activating Factor; Platelet Count; Rats; Rats, Inbred Strains; Thromboxane B2; Triazoles

1990
Limited interference of specific Paf antagonists with hyper-responsiveness to Paf itself of lungs from actively sensitized guinea-pigs.
    British journal of pharmacology, 1989, Volume: 97, Issue:2

    Topics: Animals; Azepines; Bronchi; Female; Guinea Pigs; Histamine; Histamine Release; Hypersensitivity; In Vitro Techniques; Lung; Male; Muscle, Smooth; Perfusion; Platelet Activating Factor; Pulmonary Edema; SRS-A; Trachea; Triazines; Triazoles

1989
Evidence for an intracellular action of platelet-activating factor in bovine cultured aortic endothelial cells.
    British journal of pharmacology, 1989, Volume: 96, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Thoracic; Azepines; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Platelet Activating Factor; Triazines; Triazoles

1989
Interactions of platelet activating factor, thromboxane A2 and leukotrienes in guinea-pig heart.
    Progress in clinical and biological research, 1989, Volume: 301

    Topics: Anaphylaxis; Animals; Azepines; Cyclooxygenase Inhibitors; Guinea Pigs; Heart; In Vitro Techniques; Indomethacin; Leukotrienes; Lipoxygenase Inhibitors; Naphthoquinones; ortho-Aminobenzoates; Platelet Activating Factor; Thromboxane A2; Triazines; Triazoles

1989
Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086. Correlation between receptor binding and function.
    FEBS letters, 1989, Feb-27, Volume: 244, Issue:2

    Topics: Azepines; Glucuronidase; Humans; In Vitro Techniques; Kinetics; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles

1989
Structure-activity relationships and effects of platelet-activating factor antagonists in the hetrazepine series.
    International archives of allergy and applied immunology, 1989, Volume: 88, Issue:1-2

    Topics: Azepines; Computer Simulation; Drug Design; Humans; In Vitro Techniques; Models, Molecular; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazines; Triazoles

1989
The benzodiazepine receptor ligands RO 5-4864 and RO 15-1788 do not block the inhibition of PAF-induced platelet aggregation seen with the hetrazepine WEB2086.
    Biochemical and biophysical research communications, 1989, Apr-14, Volume: 160, Issue:1

    Topics: Adenosine Triphosphate; Animals; Azepines; Benzodiazepinones; Blood Platelets; Female; Flumazenil; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, GABA-A; Triazines; Triazoles

1989
Stimulation of degranulation from human eosinophils by platelet-activating factor.
    Journal of immunology (Baltimore, Md. : 1950), 1989, May-15, Volume: 142, Issue:10

    Topics: Alkaline Phosphatase; Azepines; Calcium; Cytoplasmic Granules; Eosinophil Peroxidase; Eosinophils; Extracellular Space; Glucuronidase; Humans; Kinetics; Peroxidases; Platelet Activating Factor; Superoxides; Triazines; Triazoles

1989
PAF-receptors on eosinophils: identification with a novel ligand, [3H]WEB 2086.
    Biochemical pharmacology, 1989, May-15, Volume: 38, Issue:10

    Topics: Animals; Azepines; Eosinophils; Guinea Pigs; Peroxidases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles

1989
Presence of specific platelet-activating factor binding sites in the rat retina.
    European journal of pharmacology, 1989, Apr-12, Volume: 163, Issue:1

    Topics: Animals; Azepines; Diterpenes; Ginkgolides; In Vitro Techniques; Lactones; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Retina; Triazines; Triazoles

1989
Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils.
    Biochemical and biophysical research communications, 1989, Jul-14, Volume: 162, Issue:1

    Topics: Animals; Azepines; Calcium; Eosinophil Peroxidase; Eosinophils; Guinea Pigs; Magnesium; Male; Peroxidases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Superoxides; Triazines; Triazoles

1989
Intracellular platelet-activating factor regulates eicosanoid generation in guinea-pig resident peritoneal macrophages.
    British journal of pharmacology, 1989, Volume: 98, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Azepines; Calcimycin; Chromatography, High Pressure Liquid; Culture Media; Dinoprostone; Eicosanoids; Guinea Pigs; In Vitro Techniques; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Platelet Activating Factor; Superoxides; Triazines; Triazoles

1989
[3H]WEB 2086 labels platelet activating factor receptors in guinea pig and human lung.
    European journal of pharmacology, 1989, Oct-10, Volume: 169, Issue:2-3

    Topics: Animals; Azepines; Guinea Pigs; In Vitro Techniques; Lung; Male; Membranes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles

1989
Interaction of the Paf antagonist WEB 2086 and its hetrazepine analogues with human platelets and endothelial cells.
    British journal of pharmacology, 1989, Volume: 98, Issue:2

    Topics: Azepines; Blood Platelets; Calcium; Cytosol; Endothelium, Vascular; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles; Umbilical Veins

1989
PAF-acether-induced mortality in mice: protection by benzodiazepines.
    Drugs under experimental and clinical research, 1989, Volume: 15, Issue:11-12

    Topics: Adrenergic beta-Agonists; Albuterol; Animals; Benzodiazepines; Cattle; Death; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice; Plant Extracts; Platelet Activating Factor; Pyrilamine; Triazoles

1989
Effects of platelet-activating factor on ion transport in isolated rat jejunum.
    The American journal of physiology, 1989, Volume: 257, Issue:5 Pt 1

    Topics: Animals; Azepines; Biological Transport; Diterpenes; Electric Conductivity; Ginkgolides; In Vitro Techniques; Ions; Jejunum; Lactones; Male; Mast Cells; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thioxanthenes; Triazines; Triazoles; Xanthones

1989
Platelet-activating factor (PAF) acts as an intercellular messenger in the changes of cytosolic free Ca2+ in human neutrophils induced by opsonized particles.
    FEBS letters, 1989, Dec-18, Volume: 259, Issue:1

    Topics: Azepines; Calcium; Cytosol; Humans; In Vitro Techniques; Neutrophils; Phagocytosis; Platelet Activating Factor; Signal Transduction; Triazines; Triazoles; Zymosan

1989
Chemotactic effect of PAF-acether on peritoneal eosinophils from normal rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1989, Volume: 22, Issue:9

    Topics: Animals; Azepines; Chemotactic Factors; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Diterpenes; Eosinophils; Ginkgolides; In Vitro Techniques; Lactones; Male; Peritoneal Cavity; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazoles

1989
The pathophysiological role of PAF in anaphylactic lung reaction in the guinea pig and in endotoxin shock evidenced by the specific PAF-antagonist WEB 2086.
    Progress in clinical and biological research, 1989, Volume: 308

    Topics: Anaphylaxis; Animals; Antigens; Azepines; Disease Models, Animal; Endotoxins; Escherichia coli; Guinea Pigs; Lung Diseases; Ovalbumin; Platelet Activating Factor; Pyrilamine; Shock, Septic; Triazines; Triazoles

1989
Endothelin-induced sudden death and the possible involvement of platelet activating factor (PAF).
    Life sciences, 1989, Volume: 45, Issue:20

    Topics: Animals; Aspirin; Azepines; Blood Pressure; Death, Sudden; Dexamethasone; Diltiazem; Electrocardiography; Endothelins; Guinea Pigs; Hypertension; Hypotension; Male; Mice; Mice, Inbred ICR; Peptides; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Triazines; Triazoles

1989
Protective effects of a specific platelet activating factor (PAF) antagonist, WEB 2086, in traumatic shock.
    Thrombosis research, 1989, Feb-01, Volume: 53, Issue:3

    Topics: Animals; Azepines; Blood Pressure; Cathepsin D; Male; Mice; Myocardial Depressant Factor; Nitrogen; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock, Traumatic; Triazines; Triazoles

1989
A possible role for PAF in allergen-induced late responses: modification by a selective antagonist.
    Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 66, Issue:5

    Topics: Aerosols; Allergens; Animals; Antigens, Helminth; Ascaris; Asthma; Azepines; Chlorpheniramine; Chromones; Disease Models, Animal; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Indomethacin; Lung; Platelet Activating Factor; Reference Values; Sheep; SRS-A; Triazines; Triazoles

1989
PAF-induced platelet aggregation ex vivo as a method for monitoring pharmacological activity in healthy volunteers.
    Methods and findings in experimental and clinical pharmacology, 1989, Volume: 11, Issue:6

    Topics: Adult; Azepines; Blood Pressure; Double-Blind Method; Electrocardiography; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Triazines; Triazoles

1989
Platelet aggregation in whole blood: is the response to adrenaline, 5-hydroxytryptamine and PAF a direct consequence of stimulation by these agonists?
    Thrombosis research, 1989, Apr-15, Volume: 54, Issue:2

    Topics: Apyrase; Azepines; Cell Count; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Hirudins; Humans; Idazoxan; Indomethacin; Ketanserin; Platelet Activating Factor; Platelet Aggregation; Serotonin; Triazines; Triazoles

1989
Interference of WEB 2086 and BN 52021 with Paf-induced effects on guinea-pig trachea.
    British journal of pharmacology, 1989, Volume: 97, Issue:2

    Topics: Animals; Azepines; Dinoprostone; Diterpenes; Ginkgolides; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Lactones; Male; Muscle Relaxation; Muscle, Smooth; Platelet Activating Factor; Trachea; Triazines; Triazoles

1989
Platelet-activating factor (Paf) antagonist, WEB 2086, protects against Paf-induced hypotension in Macaca fascicularis.
    British journal of pharmacology, 1989, Volume: 97, Issue:3

    Topics: Animals; Azepines; Blood Pressure; Dose-Response Relationship, Drug; Histamine; Macaca fascicularis; Male; Platelet Activating Factor; Triazines; Triazoles

1989
The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin.
    British journal of pharmacology, 1989, Volume: 97, Issue:3

    Topics: Acetylcholine; Animals; Azepines; Bronchi; Diterpenes; Ginkgolides; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Lactones; Male; Phospholipid Ethers; Platelet Activating Factor; Propranolol; Respiratory Hypersensitivity; Triazines; Triazoles

1989
A PAF antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep.
    Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 67, Issue:1

    Topics: Airway Resistance; Animals; Antigens, Helminth; Ascaris; Azepines; Bronchoalveolar Lavage Fluid; Carbachol; Dose-Response Relationship, Drug; Platelet Activating Factor; Respiratory Hypersensitivity; Sheep; Triazines; Triazoles

1989
Effect of a new and specific PAF-antagonist, WEB 2086, on PAF and endotoxin/tumor necrosis factor induced changes in mortality and intestinal transit velocity.
    Progress in clinical and biological research, 1989, Volume: 308

    Topics: Animals; Azepines; Drug Synergism; Endotoxins; Gastrointestinal Motility; Mice; Platelet Activating Factor; Triazines; Triazoles; Tumor Necrosis Factor-alpha

1989
Effect of PAF-antagonists in endotoxin shock--ovine and rat experiments.
    Progress in clinical and biological research, 1989, Volume: 308

    Topics: Animals; Azepines; Blood Pressure; Diterpenes; Ginkgolides; Hemodynamics; Kinetics; Lactones; Lymph; Male; Platelet Activating Factor; Proteins; Pulmonary Artery; Rats; Rats, Inbred Strains; Sheep; Shock, Septic; Triazines; Triazoles

1989
Platelet-activating factor induces the production of leukotrienes by human monocytes.
    Biochimica et biophysica acta, 1989, Sep-04, Volume: 1013, Issue:1

    Topics: Azepines; Cells, Cultured; Chromatography, High Pressure Liquid; Diterpenes; Ginkgolides; Humans; Kinetics; Lactones; Leukotrienes; Monocytes; Plant Extracts; Platelet Activating Factor; Triazines; Triazoles

1989
The relevance of eicosanoids including PAF for the biochemical regulation of cardiac rhythm.
    Progress in clinical and biological research, 1989, Volume: 301

    Topics: Alprostadil; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Azepines; Diterpenes; Dogs; Fatty Acids, Unsaturated; Female; Ginkgolides; Guinea Pigs; Heart Rate; In Vitro Techniques; Lactones; Male; Platelet Activating Factor; Sulfonamides; Triazines; Triazoles

1989
Effect of platelet-activating factor (PAF) on porcine pulmonary vessels in vitro.
    Progress in clinical and biological research, 1989, Volume: 301

    Topics: Animals; Azepines; In Vitro Techniques; Leukotrienes; Platelet Activating Factor; Pulmonary Artery; Pulmonary Veins; Swine; Triazines; Triazoles; Vasoconstriction

1989
Tumor necrosis factor-induced lung injury is not mediated by platelet-activating factor.
    The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 1

    Topics: Animals; Azepines; Capillary Permeability; Eicosanoids; Glutathione; Lung; Male; Platelet Activating Factor; Pulmonary Circulation; Rats; Rats, Inbred Strains; Surface Properties; Triazines; Triazoles; Tumor Necrosis Factor-alpha

1989
Evidence against a role for platelet-activating factor in hypoxic pulmonary vasoconstriction in the rat.
    Clinical science (London, England : 1979), 1989, Volume: 77, Issue:4

    Topics: Animals; Azepines; Diterpenes; Ginkgolides; Hypoxia; Lactones; Male; Platelet Activating Factor; Pulmonary Circulation; Rats; Rats, Inbred Strains; Triazines; Triazoles; Vasoconstriction

1989
Density heterogeneity of eosinophil leucocytes: induction of hypodense eosinophils by platelet-activating factor.
    Immunology, 1989, Volume: 68, Issue:1

    Topics: Animals; Azepines; Centrifugation, Density Gradient; Eosinophils; Guinea Pigs; Platelet Activating Factor; Triazines; Triazoles

1989
Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages.
    British journal of pharmacology, 1988, Volume: 94, Issue:4

    Topics: Animals; Azepines; Blood Platelets; Calcimycin; Cell Aggregation; Diterpenes; Epoprostenol; Furans; Ginkgolides; In Vitro Techniques; Lactones; Macrophages; Male; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazines; Triazoles

1988
Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086.
    Lancet (London, England), 1988, Nov-12, Volume: 2, Issue:8620

    Topics: Administration, Oral; Azepines; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Count; Thrombocytopenia; Triazines; Triazoles

1988
Characterization of platelet-activating factor-induced elevation of cytosolic free calcium concentration in eosinophils.
    FEBS letters, 1989, Jan-16, Volume: 243, Issue:1

    Topics: Animals; Azepines; Calcium; Cytosol; Eosinophils; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Reference Values; Triazines; Triazoles

1989
Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan.
    British journal of pharmacology, 1989, Volume: 96, Issue:2

    Topics: Animals; Azepines; Carrageenan; Leukocyte Count; Male; Platelet Activating Factor; Pleurisy; Pyridines; Rats; Rats, Inbred Strains; Thiazoles; Triazines; Triazoles; Zymosan

1989
Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites.
    Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 338, Issue:4

    Topics: Acetylcholine; Animals; Arachidonic Acids; Atropine; Azepines; Cyclooxygenase Inhibitors; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Lipoxygenase Inhibitors; Lung; Male; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Thromboxane A2; Triazines; Triazoles

1988
PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: inhibition by specific antagonists.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:1

    Topics: Animals; Azepines; Blood Pressure; Diterpenes; Endotoxins; Ginkgolides; Lactones; Male; Microcirculation; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rats; Rats, Inbred Strains; Splanchnic Circulation; Triazines; Triazoles

1988
Inhibitory effect of oral WEB 2086, a novel selective PAF-acether antagonist, on ex vivo platelet aggregation.
    European journal of clinical pharmacology, 1988, Volume: 35, Issue:3

    Topics: Adult; Azepines; Double-Blind Method; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Random Allocation; Triazines; Triazoles

1988
The thieno-triazolodiazepine WEB 2086 inhibits platelet aggregation and ATP release from porcine platelets induced by platelet activating factor (PAF).
    Thrombosis research, 1988, Jul-15, Volume: 51, Issue:2

    Topics: Adenosine Triphosphate; Animals; Azepines; Blood Platelets; Platelet Activating Factor; Platelet Aggregation Inhibitors; Swine; Triazines; Triazoles

1988
Effect of the PAF-antagonist WEB 2086 on anaphylactic lung reaction: comparison of inhalative and intravenous challenge.
    Agents and actions. Supplements, 1988, Volume: 23

    Topics: Administration, Inhalation; Anaphylaxis; Animals; Azepines; Blood Pressure; Guinea Pigs; Injections, Intravenous; Lung; Platelet Activating Factor; Triazines; Triazoles

1988
Radioligand binding of antagonists of platelet-activating factor to intact human platelets.
    FEBS letters, 1988, Feb-15, Volume: 228, Issue:2

    Topics: Azepines; Binding Sites; Binding, Competitive; Blood Platelets; Humans; Kinetics; Platelet Activating Factor; Pyridines; Thiazoles; Triazines; Triazoles; Tritium

1988
Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man.
    British journal of pharmacology, 1988, Volume: 94, Issue:1

    Topics: Adenosine Diphosphate; Animals; Azepines; Capillary Permeability; Guinea Pigs; Humans; In Vitro Techniques; Male; Ovalbumin; Platelet Activating Factor; Platelet Aggregation; Triazines; Triazoles

1988
Platelet-activating factor induces eosinophil peroxidase release from purified human eosinophils.
    Immunology, 1988, Volume: 64, Issue:3

    Topics: Azepines; Eosinophil Peroxidase; Eosinophils; Humans; Peroxidases; Platelet Activating Factor; Triazines; Triazoles

1988
Platelet-activating factor (PAF-acether) and microcirculation: effect of Lyso-PAF and PAF-antagonists.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1987, Volume: 20, Issue:5

    Topics: Animals; Azepines; Male; Mesenteric Arteries; Microcirculation; Norepinephrine; Platelet Activating Factor; Rats; Rats, Inbred Strains; Triazines; Triazoles; Vasoconstriction

1987
Protective effect of WEB 2086, a novel antagonist of platelet activating factor, in endotoxin shock.
    European journal of pharmacology, 1987, Mar-17, Volume: 135, Issue:2

    Topics: Animals; Azepines; Blood Pressure; Male; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock, Septic; Triazines; Triazoles

1987
WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage.
    Pharmacological research communications, 1987, Volume: 19, Issue:2

    Topics: Animals; Azepines; Gastric Mucosa; Platelet Activating Factor; Rats; Stomach Ulcer; Triazines; Triazoles

1987
Effects of WEB 2086, a novel antagonist of platelet activating factor, in active and passive anaphylaxis.
    Immunopharmacology, 1987, Volume: 13, Issue:2

    Topics: Administration, Oral; Anaphylaxis; Animals; Azepines; Blood Pressure; Guinea Pigs; Immunization; Immunization, Passive; Injections, Intravenous; Male; Mice; Ovalbumin; Platelet Activating Factor; Pyrilamine; Respiration; Triazines; Triazoles

1987
Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:3

    Topics: Animals; Anticonvulsants; Azepines; Capillary Permeability; Chemical Phenomena; Chemistry; Guinea Pigs; Humans; Hypnotics and Sedatives; Indium; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Skin; Triazines; Triazoles

1987
Interference by the novel PAF-acether antagonist WEB 2086 with the bronchopulmonary responses to PAF-acether and to active and passive anaphylactic shock in guinea-pigs.
    European journal of pharmacology, 1987, Aug-21, Volume: 140, Issue:3

    Topics: Anaphylaxis; Animals; Azepines; Female; Guinea Pigs; Histamine; In Vitro Techniques; Indicators and Reagents; Leukopenia; Male; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; Radioimmunoassay; Respiratory System; Spectrometry, Fluorescence; Thrombocytopenia; Thromboxane B2; Triazines; Triazoles

1987
Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist.
    British journal of pharmacology, 1987, Volume: 91, Issue:4

    Topics: Animals; Azepines; Blood Pressure; Bronchi; Female; In Vitro Techniques; Lung; Organ Size; Platelet Activating Factor; Pulmonary Artery; Rats; Rats, Inbred Strains; Triazines; Triazoles

1987
PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines.
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:5

    Topics: Azepines; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Thiophenes; Triazoles

1987
Effects of platelet-activating factor antagonists WEB 2086 and BN 50730 on digoxin-induced arrhythmias.
    Pharmacology & toxicology, 1995, Volume: 76, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Azepines; Digoxin; Female; Guinea Pigs; Hemodynamics; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Thienopyridines; Triazoles

1995
Effect of a platelet-activating factor antagonist on pancreas perfusion after 24 h of ischemia.
    Pancreas, 1995, Volume: 11, Issue:2

    Topics: Animals; Azepines; Cold Temperature; Ischemia; Pancreas; Platelet Activating Factor; Reperfusion; Swine; Tissue Preservation; Triazoles

1995
PAF effects on eicosanoid release in neonatal rat cardiomyocytes.
    Prostaglandins, leukotrienes, and essential fatty acids, 1995, Volume: 53, Issue:3

    Topics: Animals; Animals, Newborn; Aspirin; Azepines; Cyclooxygenase Inhibitors; Epoprostenol; Heart; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thromboxane A2; Triazoles

1995
Beneficial effect of the platelet-activating factor antagonist WEB 2170 on reperfusion injury after orthotopic liver transplantation.
    Transplantation proceedings, 1995, Volume: 27, Issue:5

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azepines; Bilirubin; Body Weight; Graft Survival; Liver; Liver Function Tests; Liver Transplantation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Reperfusion Injury; Swine; Time Factors; Triazoles

1995
Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis.
    The Journal of experimental medicine, 1994, Jul-01, Volume: 180, Issue:1

    Topics: Animals; Azepines; Collagen; Drug Combinations; Female; Laminin; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Platelet Activating Factor; Proteoglycans; Triazoles; Tumor Necrosis Factor-alpha

1994
Effect of platelet-activating factor and its antagonists on colonic dysmotility and tissue levels of colonic neuropeptides.
    European journal of pharmacology, 1994, Apr-11, Volume: 256, Issue:1

    Topics: Alprazolam; Animals; Azepines; Colitis; Colon; Gastrointestinal Motility; In Vitro Techniques; Iodine Radioisotopes; Neuropeptides; Platelet Activating Factor; Rabbits; Substance P; Triazoles; Vasoactive Intestinal Peptide

1994
Nitric oxide synthase inhibitors 7- and 6-nitroindazole relax smooth muscle in vitro.
    European journal of pharmacology, 1994, Apr-11, Volume: 256, Issue:1

    Topics: Alprazolam; Animals; Azepines; Colitis; Colon; Gastrointestinal Motility; In Vitro Techniques; Iodine Radioisotopes; Neuropeptides; Platelet Activating Factor; Rabbits; Substance P; Triazoles; Vasoactive Intestinal Peptide

1994
Potentiation of histamine release from human leucocytes by PAF.
    Agents and actions, 1994, Volume: 41, Issue:1-2

    Topics: Adolescent; Adult; Antibodies, Anti-Idiotypic; Azepines; Chemotactic Factors; Dipeptides; Female; Granulocytes; Histamine Release; Humans; Hypersensitivity, Immediate; Immunoglobulin E; In Vitro Techniques; Leukocytes; Male; Platelet Activating Factor; Triazoles

1994
Platelet-activating factor-induced endothelial cell expression of adhesion molecules and modulation of surface glycocalyx, evaluated by electron spectroscopy chemical analysis.
    Seminars in thrombosis and hemostasis, 1994, Volume: 20, Issue:2

    Topics: Antibodies, Monoclonal; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cycloheximide; Electron Probe Microanalysis; Endothelium, Vascular; Fluorescent Antibody Technique; Gene Expression Regulation; Glycoproteins; Humans; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polysaccharides; Proteoglycans; Triazoles; Umbilical Veins

1994
The vitronectin receptor (alpha v beta 3) is implicated, in cooperation with P-selectin and platelet-activating factor, in the adhesion of monocytes to activated endothelial cells.
    The Biochemical journal, 1994, Dec-01, Volume: 304 ( Pt 2)

    Topics: Amino Acid Sequence; Antibodies, Monoclonal; Azepines; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Integrins; Molecular Sequence Data; Monocytes; Oligopeptides; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cytoadhesin; Receptors, Vitronectin; Thrombin; Triazoles; Umbilical Veins

1994
Effect of PAF antagonists on cerulein-induced pancreatitis.
    Journal of lipid mediators and cell signalling, 1995, Volume: 11, Issue:1

    Topics: Acute Disease; Amylases; Animals; Azepines; Capillary Permeability; Ceruletide; Diterpenes; Evans Blue; Ginkgolides; Lactones; Male; Pancreas; Pancreatitis; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles

1995
Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung.
    Shock (Augusta, Ga.), 1994, Volume: 1, Issue:2

    Topics: Animals; Azepines; Catalase; Cattle; Deferoxamine; Diclofenac; Female; Free Radical Scavengers; Hemoglobins; Histamine Release; Iron; Male; Perfusion; Platelet Activating Factor; Pulmonary Circulation; Rabbits; Stimulation, Chemical; Thromboxane B2; Triazoles; Vascular Resistance; Vasoconstriction

1994
Mechanisms of oxidized chylomicron-induced leukocyte-endothelial cell adhesion.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 2

    Topics: Animals; Antibodies, Monoclonal; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Chylomicrons; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Lipid Peroxidation; Male; Microcirculation; Oxidation-Reduction; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triazoles

1995
Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.
    The Journal of clinical investigation, 1995, Volume: 96, Issue:2

    Topics: Aged; Animals; Azepines; Base Sequence; Cell Line; Chemotaxis; Choriocarcinoma; Collagen; Culture Media, Conditioned; Cytokines; Dogs; Drug Combinations; Endothelium, Vascular; Female; Growth Substances; Humans; Interleukin-1; Laminin; Lymphoma, Large B-Cell, Diffuse; Macrophages; Male; Mice; Mice, Inbred DBA; Molecular Sequence Data; Neoplasm Proteins; Neovascularization, Pathologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sarcoma, Kaposi; Skin Neoplasms; Thrombin; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Umbilical Veins; Uterine Neoplasms

1995
Platelet-activating factor mediated potentiation of stimulation-evoked catecholamine release and the rise in intracellular free Ca2+ concentration in adrenal chromaffin cells.
    Journal of lipid mediators and cell signalling, 1995, Volume: 11, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Adrenal Glands; Animals; Azepines; Caffeine; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Dose-Response Relationship, Drug; Kinetics; Platelet Activating Factor; Platelet Membrane Glycoproteins; Potassium Chloride; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Stimulation, Chemical; Time Factors; Triazoles

1995
Nitric oxide inhibition does not prevent the hypotensive response to increased renal perfusion in rabbits.
    Clinical and experimental pharmacology & physiology, 1995, Volume: 22, Issue:5

    Topics: Animals; Arginine; Azepines; Blood Pressure; Diuresis; Enzyme Inhibitors; Extracorporeal Circulation; Female; Kidney; Male; Natriuresis; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Perfusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Renal Circulation; Sodium Bicarbonate; Triazoles; Vascular Resistance

1995
[The effect of platelet-activating factor antagonists on early bacteria translocation of rat after burn injury].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 1995, Volume: 33, Issue:4

    Topics: Animals; Azepines; Bacterial Translocation; Burns; Escherichia coli; Escherichia coli Infections; Platelet Activating Factor; Random Allocation; Rats; Rats, Wistar; Triazoles

1995
Platelet-activating factor stimulates gastric acid secretion in isolated rabbit gastric glands.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1

    Topics: Aminopyrine; Animals; Azepines; Biological Transport; Calcium; Carbachol; Dose-Response Relationship, Drug; Egtazic Acid; Famotidine; Fluorescent Dyes; Gastric Acid; Gastric Mucosa; Histamine; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Rabbits; Thiazoles; Thienopyridines; Triazoles; Verapamil

1995
Biosynthesis of platelet-activating factor in normal and inflamed human colon mucosa: evidence for the involvement of the pathway of platelet-activating factor synthesis de novo in inflammatory bowel disease.
    Clinical science (London, England : 1979), 1995, Volume: 88, Issue:6

    Topics: Aged; Azepines; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Colon; Culture Techniques; Cytidine Diphosphate Choline; Female; Glyceryl Ethers; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Middle Aged; Platelet Activating Factor; Triazoles

1995
Growth arrest vs direct cytotoxicity and the importance of molecular structure for the in vitro anti-tumour activity of ether lipids.
    British journal of cancer, 1995, Volume: 72, Issue:2

    Topics: Animals; Antineoplastic Agents; Azepines; Cell Cycle; Cell Division; Cell Membrane; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Mammary Neoplasms, Experimental; Mice; Phospholipid Ethers; Platelet Activating Factor; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured

1995
Mast cell mediators and peritoneal adhesion formation in the rat.
    The Journal of surgical research, 1995, Volume: 59, Issue:3

    Topics: Animals; Azepines; Disease Models, Animal; Histamine Antagonists; Leukotriene D4; Male; Mast Cells; Methysergide; Ondansetron; Peritoneal Diseases; Platelet Activating Factor; Propionates; Pyrilamine; Quinolines; Ranitidine; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Tissue Adhesions; Triazoles

1995
Protective effect of a specific PAF antagonist on vincristine-induced experimental retinopathy.
    Acta ophthalmologica Scandinavica, 1995, Volume: 73, Issue:2

    Topics: Animals; Azepines; Dark Adaptation; Electroretinography; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Thienopyridines; Triazoles; Vincristine

1995
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo[4,5-c]pyridine.
    Journal of medicinal chemistry, 1995, Sep-01, Volume: 38, Issue:18

    Topics: Animals; Azepines; Benzodiazepines; Imidazoles; Mice; Platelet Activating Factor; Pyridines; Rabbits; Structure-Activity Relationship; Thiazoles; Triazoles

1995
Endothelin-1 induces neutrophil-independent vascular injury in the rat gastric microcirculation.
    European journal of pharmacology, 1995, May-04, Volume: 278, Issue:1

    Topics: Animals; Azepines; Capillary Permeability; Disease Models, Animal; Endothelins; Endothelium, Vascular; Gastric Mucosa; Infusions, Intra-Arterial; Isotope Labeling; Male; Methacrylates; Neutrophils; Platelet Activating Factor; Rats; Rats, Wistar; Serum Albumin; Stomach Ulcer; Thromboxane-A Synthase; Triazoles

1995
Platelet adhesion to cultured bovine cerebral microvascular endothelial cells by stimulation of platelet activating factor and antagonism of drugs.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995, Volume: 16, Issue:4

    Topics: Alkaloids; Animals; Azepines; Benzylisoquinolines; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Microcirculation; Platelet Activating Factor; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Triazoles

1995
Platelet-activating factor antagonists (BN 52021 and BN 50730) inhibit tumor necrosis factor-alfa-mediated cytotoxicity on murine L929 tumor cells.
    Molecular immunology, 1993, Volume: 30, Issue:6

    Topics: Animals; Aprotinin; Azepines; Cytotoxicity, Immunologic; Diterpenes; Dose-Response Relationship, Immunologic; Ginkgolides; Lactones; Mice; Platelet Activating Factor; Tetrazoles; Thienopyridines; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1993
Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage.
    Circulation research, 1993, Volume: 73, Issue:1

    Topics: Albumins; Animals; Arginine; Azepines; Blood Flow Velocity; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cyclic GMP; Intercellular Adhesion Molecule-1; Leukocytes; Male; NG-Nitroarginine Methyl Ester; P-Selectin; Phalloidine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Triazoles; Venules

1993
Inhibition of leukocyte adhesion to endothelial cells of human umbilical vein by Y-24180, an antagonist of platelet-activating factor.
    International journal of immunopharmacology, 1993, Volume: 15, Issue:6

    Topics: Animals; Antigens, CD; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Edema; Endothelium, Vascular; Guinea Pigs; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Male; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Triazoles; Umbilical Veins

1993
Activation of capsaicin-sensitive sensory fibers modulates PAF-induced bronchial hyperresponsiveness in anesthetized guinea pigs.
    The American review of respiratory disease, 1993, Volume: 148, Issue:4 Pt 1

    Topics: Anesthesia; Animals; Azepines; Bronchial Hyperreactivity; Bronchoconstriction; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Male; Nerve Fibers; Platelet Activating Factor; Ruthenium Red; Serum Albumin, Bovine; Time Factors; Triazoles

1993
Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide.
    Circulation research, 1993, Volume: 73, Issue:6

    Topics: Amino Acid Oxidoreductases; Animals; Azepines; Blood Vessels; Cardiovascular System; Cells, Cultured; Enzyme Induction; Lipopolysaccharides; Macrophages; Male; Mice; Nitric Oxide Synthase; Nitrites; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles; Vasomotor System

1993
Increased prostaglandin I2 and thromboxane A2 production by rat dental pulp after intravenous administration of endotoxin.
    Archives of oral biology, 1994, Volume: 39, Issue:11

    Topics: Animals; Arachidonic Acid; Azepines; Dental Pulp; Endotoxins; Epoprostenol; Escherichia coli; Indomethacin; Injections, Intravenous; Jejunum; Lung; Male; Platelet Activating Factor; Rats; Rats, Wistar; Thromboxane A2; Time Factors; Triazoles

1994
Treatment of carrageenan induced arthritis by the platelet activating factor antagonist BN 50730.
    Annals of the rheumatic diseases, 1995, Volume: 54, Issue:2

    Topics: Animals; Arthritis, Experimental; Azepines; Carrageenan; Injections, Intra-Articular; Platelet Activating Factor; Rabbits; Thienopyridines; Triazoles

1995
Platelet-activating factor mediates trinitrobenzene induced colitis.
    Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 51, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Colitis; Colon; Dinoprostone; Eicosanoids; Gastrointestinal Contents; Leukotriene B4; Platelet Activating Factor; Rabbits; Second Messenger Systems; Thromboxane B2; Triazoles; Trinitrobenzenesulfonic Acid

1994
Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor.
    Blood, 1995, May-01, Volume: 85, Issue:9

    Topics: Animals; Azepines; Cell Adhesion; Chemotaxis, Leukocyte; Dihydropyridines; Edema; Imidazoles; Inflammation; Interleukin-1; Leukocytes; Male; Mesentery; Microcirculation; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Skin; Triazoles

1995
Role of thromboxane A2 and platelet-activating factor in allergic bronchoconstriction in guinea pig airway in vivo.
    Journal of lipid mediators and cell signalling, 1995, Volume: 11, Issue:1

    Topics: Administration, Inhalation; Animals; Antigens; Asthma; Azepines; Bridged Bicyclo Compounds; Bronchoconstriction; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Guinea Pigs; Hypersensitivity; Male; Platelet Activating Factor; Receptors, Prostaglandin; Thromboxane A2; Triazoles

1995
Mechanisms for lipoxin A4 induced neutrophil dependent cytotoxicity for human endothelial cells.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Azepines; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotriene B4; Lipoxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Triazoles; Umbilical Veins; Virulence Factors, Bordetella

1995
Evidence for the predominant role of intracellular PAF binding sites in the regulation of phospholipase A2 in human neutrophils.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Alkaloids; Azepines; Humans; Indoles; Leukotriene Antagonists; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Triazoles

1995
The role of platelet-activating factor in lipopolysaccharide-induced myocardial depression in guinea pigs.
    Journal of critical care, 1995, Volume: 10, Issue:1

    Topics: Animals; Azepines; Depression, Chemical; Drug Interactions; Escherichia coli; Female; Guinea Pigs; Isoproterenol; Lipopolysaccharides; Male; Myocardial Contraction; Phenylephrine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Time Factors; Triazoles

1995
Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2.
    The American journal of physiology, 1995, Volume: 268, Issue:5 Pt 2

    Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Hindlimb; Ibuprofen; Male; Phenylacetates; Platelet Activating Factor; Rats; Rats, Wistar; Regional Blood Flow; Sulfonamides; Thromboxane A2; Thromboxanes; Triazoles; Vascular Resistance

1995
Occurrence of disseminated intravascular coagulation (DIC) in active systemic anaphylaxis: role of platelet-activating factor.
    Clinical and experimental immunology, 1995, Volume: 100, Issue:3

    Topics: Anaphylaxis; Animals; Azepines; Disseminated Intravascular Coagulation; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Platelet Activating Factor; Triazoles

1995
Presence of specific platelet-activating factor binding-sites in neuroblastoma N1E-115 cells.
    Neuroscience letters, 1995, Feb-17, Volume: 186, Issue:2-3

    Topics: Animals; Azepines; Binding Sites; Binding, Competitive; Brain Neoplasms; Diterpenes; Ginkgolides; Kinetics; Lactones; Mice; Neuroblastoma; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles; Tumor Cells, Cultured

1995
Platelet activating factor induces nerve growth factor production by rat astrocytes.
    Neuroscience letters, 1995, Feb-15, Volume: 186, Issue:1

    Topics: Animals; Astrocytes; Azepines; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Kinetics; Nerve Growth Factors; Nerve Tissue Proteins; Platelet Activating Factor; Rats; Triazoles; Tumor Necrosis Factor-alpha

1995
1-O-hexadecyl-2-metoxy-glycero-3-phosphatidylcholine--a methoxy ether lipid inhibiting platelet activating factor-induced platelet aggregation and neutrophil oxidative metabolism.
    Biochemical pharmacology, 1995, May-26, Volume: 49, Issue:11

    Topics: Azepines; Blood Platelets; Calcium; Humans; Luminescent Measurements; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Triazoles

1995
Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia.
    Cardiovascular research, 1995, Volume: 29, Issue:4

    Topics: Adenosine; Animals; Azepines; Guinea Pigs; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophil Activation; Neutrophils; Perfusion; Platelet Activating Factor; Receptors, Purinergic P1; Theobromine; Triazoles; Xanthines

1995
Platelet-activating factor mediates the ozone-induced increase in airway microvascular leakage in guinea pigs.
    European journal of pharmacology, 1995, Mar-16, Volume: 292, Issue:3-4

    Topics: Animals; Azepines; Bronchi; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Inflammation Mediators; Male; Ozone; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Physiological Phenomena; Respiratory System; Trachea; Triazoles

1995
Platelet-activating factor receptor antagonist improves renal function and glomerular lesions in renal ablation.
    The Journal of laboratory and clinical medicine, 1994, Volume: 124, Issue:6

    Topics: Albuminuria; Animals; Azepines; Blood Pressure; Body Weight; Eicosanoids; Inulin; Kidney; Kidney Glomerulus; Male; Nephrectomy; Organ Size; p-Aminohippuric Acid; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles

1994
Pharmacological profile of UK-74,505, a novel and selective PAF antagonist with potent and prolonged oral activity.
    Journal of lipid mediators and cell signalling, 1994, Volume: 10, Issue:3

    Topics: Administration, Oral; Animals; Aorta; Azepines; Blood Platelets; Brain; Calcium Channels, L-Type; Capillary Permeability; Cattle; Dihydropyridines; Diltiazem; Gallopamil; Guinea Pigs; Hypotension; Imidazoles; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Proteins; Nitrendipine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Potassium Chloride; Rabbits; Rats; Rats, Sprague-Dawley; Skin; Triazoles; Tritium

1994
Antagonism of neutrophil adherence in the deteriorating stroke model in rabbits.
    Journal of neurosurgery, 1995, Volume: 82, Issue:2

    Topics: Animals; Azepines; Cell Adhesion; Cerebrovascular Disorders; Ischemia; Male; Neutrophils; Platelet Activating Factor; Rabbits; Reperfusion Injury; Spinal Cord; Triazoles

1995
Quantitative measurement of a new synthetic hetrazepine derivative, BN50730, in human plasma and urine by combined liquid chromatography-negative chemical ionization mass spectrometry using a particle beam interface.
    Journal of chromatography. B, Biomedical applications, 1994, Aug-19, Volume: 658, Issue:2

    Topics: Adult; Azepines; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Male; Mass Spectrometry; Platelet Activating Factor; Quality Control; Spectrophotometry, Ultraviolet; Thienopyridines; Triazoles

1994
Evidence for a colonic PAF receptor.
    The Journal of surgical research, 1995, Volume: 58, Issue:1

    Topics: Animals; Azepines; Colon; Eicosanoids; In Vitro Techniques; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1995
Platelet-activating factor and sepsis-induced small intestinal microvascular hypoperfusion.
    The Journal of surgical research, 1995, Volume: 58, Issue:1

    Topics: Animals; Azepines; Bacteremia; Escherichia coli Infections; Intestine, Small; Male; Microcirculation; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles; Vasoconstriction

1995
Permeability of ferret trachea in vitro to 99mTc-DTPA and [14C]antipyrine.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:3

    Topics: Animals; Antipyrine; Azepines; Cell Membrane Permeability; Epithelium; Female; Ferrets; Male; Membrane Potentials; Muscle, Smooth; Platelet Activating Factor; Technetium Tc 99m Pentetate; Trachea; Triazoles

1994
Characterization of a behavioral model for peripherally evoked itch suggests platelet-activating factor as a potent pruritogen.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:2

    Topics: Animals; Azepines; Female; Guinea Pigs; Histamine; Male; Platelet Activating Factor; Pruritus; Pyridinium Compounds; Triazoles

1995
Long-lasting inhibitory activity of the hetrazepinic BN 50730 on exudation and cellular alterations evoked by PAF and LPS.
    British journal of pharmacology, 1994, Volume: 113, Issue:3

    Topics: Animals; Azepines; Cell Movement; Chemotaxis, Leukocyte; Exudates and Transudates; Female; Leukocytes; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Aggregation; Rabbits; Rats; Rats, Wistar; Thienopyridines; Triazoles

1994
Interactions of constitutive nitric oxide with PAF and thromboxane on rat intestinal vascular integrity in acute endotoxaemia.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Animals; Azepines; Blood Pressure; Capillaries; Capillary Permeability; Cyclooxygenase Inhibitors; Diterpenes; Escherichia coli; Ginkgolides; Intestinal Mucosa; Intestines; Lactones; Lipopolysaccharides; Male; Nitric Oxide; Phenylephrine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Thromboxane; Thromboxane A2; Triazoles

1994
Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils.
    European journal of pharmacology, 1994, Nov-15, Volume: 269, Issue:3

    Topics: Animals; Azepines; Binding, Competitive; Calcium; Cell Count; Cell Degranulation; Chemotaxis, Leukocyte; Free Radical Scavengers; Inositol 1,4,5-Trisphosphate; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Standards; Signal Transduction; Structure-Activity Relationship; Superoxides; Thiazoles; Thiazolidines; Triazoles; Vitamin E

1994
Effect of platelet activating factor antagonists in different models of thrombosis.
    Thrombosis research, 1994, Dec-15, Volume: 76, Issue:6

    Topics: Animals; Arterial Occlusive Diseases; Azepines; Cats; Diterpenes; Ginkgolides; Lactones; Male; Mice; Mice, Inbred Strains; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thiazoles; Thrombophlebitis; Triazoles

1994
Functional PAF receptors in glia cells: binding parameters and regulation of expression.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1994, Volume: 12, Issue:7

    Topics: Animals; Animals, Newborn; Astrocytes; Azepines; Bucladesine; Calcium; Calcium Radioisotopes; Cells, Cultured; Gene Expression Regulation, Developmental; Insulin; Kinetics; Nerve Tissue Proteins; Neuroglia; Oligodendroglia; Phenotype; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1994
The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs.
    Auris, nasus, larynx, 1993, Volume: 20, Issue:3

    Topics: Airway Resistance; Animals; Azepines; Chromones; Guinea Pigs; Histamine H1 Antagonists; Immunization; Lipoxygenase Inhibitors; Male; Ovalbumin; Phthalazines; Platelet Activating Factor; Pyrilamine; Rhinitis, Allergic, Perennial; Sneezing; SRS-A; Thiazoles; Thiazolidines; Triazoles

1993
Molecular mechanisms involved in superoxide-induced leukocyte-endothelial cell interactions in vivo.
    The American journal of physiology, 1994, Volume: 266, Issue:2 Pt 2

    Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Azepines; Blood Pressure; Catalase; CD18 Antigens; Endothelium, Vascular; Free Radical Scavengers; Hypoxanthine; Hypoxanthines; Leukocytes; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Receptors, Leukocyte-Adhesion; Splanchnic Circulation; Superoxides; Triazoles; Xanthine Oxidase

1994
Endothelial cell-associated platelet-activating factor primes neutrophils for enhanced superoxide production and arachidonic acid release during adhesion to but not transmigration across IL-1 beta-treated endothelial monolayers.
    Journal of immunology (Baltimore, Md. : 1950), 1994, Oct-15, Volume: 153, Issue:8

    Topics: Arachidonic Acid; Azepines; Cell Adhesion; Cell Movement; Cell Polarity; Endothelium, Vascular; Humans; In Vitro Techniques; Interleukin-1; Neutrophil Activation; Neutrophils; Piperazines; Platelet Activating Factor; Superoxides; Thiazoles; Thiazolidines; Triazoles

1994
Functional platelet-activating factor receptors linked to inositol lipid hydrolysis, calcium mobilization and tyrosine kinase activity in the human endometrial HEC-1B cell line.
    Journal of reproduction and fertility, 1994, Volume: 101, Issue:2

    Topics: Azepines; Calcium; Cell Line; Endometrium; Female; Fura-2; Humans; Hydrolysis; Inositol; Inositol 1,4,5-Trisphosphate; Lipid Metabolism; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1994
Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet-activating factor in eosinophil activation.
    American journal of respiratory cell and molecular biology, 1994, Volume: 11, Issue:5

    Topics: Alkaloids; Animals; Azepines; Calcium; Cell Membrane; Cytosol; Eosinophil Peroxidase; Eosinophils; Guinea Pigs; Male; Peritoneal Lavage; Peroxidases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Triazoles

1994
Determination of the platelet activating factor antagonist 6-(2- chlorophenyl)-9-[(4-methoxyphenyl)thiocarbamoyl]-1-methyl-7,8,9,10- tetrahydro-4H-pyrido[4',3'-4,5]-thieno[3,2-f][1,2,4]triazolo[4, 3-a][1,4] diazepine in human plasma by liquid chromatograp
    Journal of chromatography. B, Biomedical applications, 1994, Jul-01, Volume: 657, Issue:1

    Topics: Azepines; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Mass Spectrometry; Microchemistry; Platelet Activating Factor; Quality Control; Sensitivity and Specificity; Thienopyridines; Triazoles

1994
Role of R-type calcium channels in the response of the perfused arterial and venous mesenteric vasculature of the rat to platelet-activating factor.
    British journal of pharmacology, 1994, Volume: 112, Issue:4

    Topics: Animals; Arginine; Azepines; Calcium Channels; Isradipine; Male; Mesenteric Arteries; Mesenteric Veins; NG-Nitroarginine Methyl Ester; Perfusion; Platelet Activating Factor; Quinolinium Compounds; Rats; Rats, Wistar; Triazoles

1994
WEB-2086 and indomethacin do not modify blood pressure fall on unclipping hypertensive rats.
    Clinical and experimental pharmacology & physiology, 1994, Volume: 21, Issue:5

    Topics: Animals; Azepines; Blood Pressure; Disease Models, Animal; Hypertension, Renal; Indomethacin; Injections, Intravenous; Male; Platelet Activating Factor; Rats; Rats, Wistar; Renal Artery; Triazoles

1994
Agonist-induced up-regulation of platelet-activating factor receptor messenger RNA in human monocytes.
    European journal of pharmacology, 1994, Jul-15, Volume: 268, Issue:2

    Topics: Adult; Azepines; Gene Expression Regulation; Humans; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles; Up-Regulation

1994
Changes of cytosolic calcium ion concentrations in human endothelial cells in response to thrombin, platelet-activating factor, and leukotriene B4.
    The Journal of laboratory and clinical medicine, 1994, Volume: 124, Issue:5

    Topics: Azepines; Calcium; Cells, Cultured; Cytosol; Endothelium, Vascular; Fura-2; Humans; Ions; Leukotriene B4; Osmolar Concentration; Platelet Activating Factor; Thrombin; Triazoles

1994
Interactions between leukotrienes and histamine in the anaphylactic contraction of guinea pig lung parenchyma.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lung; Male; Muscle Contraction; Ovalbumin; Platelet Activating Factor; Quinolines; Triazoles

1994
Delayed treatment with platelet activating factor receptor antagonist web 2086 attenuates pulmonary dysfunction in porcine endotoxin shock.
    The Journal of trauma, 1994, Volume: 37, Issue:5

    Topics: Animals; Azepines; Blood Pressure; Cathepsin B; Creatinine; Extravascular Lung Water; Hypertension, Pulmonary; Lipopolysaccharides; Lung; Platelet Activating Factor; Pulmonary Artery; Pulmonary Gas Exchange; Salmonella; Shock, Septic; Swine; Swine, Miniature; Triazoles; Tumor Necrosis Factor-alpha; Vascular Resistance

1994
[Effects of calcimycin on platelet adhesion to cultured bovine cerebral microvascular endothelial cells and its antagonism by drugs].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1994, Volume: 29, Issue:5

    Topics: Alkaloids; Animals; Azepines; Benzylisoquinolines; Brain; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Male; Microcirculation; Platelet Activating Factor; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Pyrans; Rabbits; Triazoles

1994
Platelet-activating factor induced calcium mobilization and phosphoinositide metabolism in cultured bovine cerebral microvascular endothelial cells.
    Biochimica et biophysica acta, 1994, Nov-10, Volume: 1224, Issue:2

    Topics: Animals; Azepines; Brain; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Endothelium, Vascular; Phosphatidylinositols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles

1994
Platelet-activating factor and WEB-2086 directly modulate rat cardiomyocyte contractility.
    Journal of molecular and cellular cardiology, 1994, Volume: 26, Issue:2

    Topics: Animals; Azepines; In Vitro Techniques; Kinetics; Myocardial Contraction; Myocardium; Platelet Activating Factor; Rats; Rats, Inbred WKY; Triazoles

1994
Effect of platelet activating factor antagonist WEB 2086 on the production of TNF from murine peritoneal macrophages.
    Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:10

    Topics: Animals; Azepines; Biological Assay; Fibrosarcoma; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Platelet Activating Factor; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1993
Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1994, Volume: 15, Issue:1

    Topics: Animals; Azepines; Cell Division; Colony-Stimulating Factors; Female; Interleukin-1; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Phagocytosis; Platelet Activating Factor; Spleen; Triazoles

1994
Pharmacological analysis of neutrophil chemotactic factor production by leucocytes and roles of PAF in allergic inflammation in rats.
    British journal of pharmacology, 1994, Volume: 111, Issue:1

    Topics: Animals; Azepines; Benzoquinones; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Furans; Hypersensitivity; Immunization; Interleukin-8; Isoelectric Focusing; Leukocytes; Lipoxygenase Inhibitors; Phospholipid Ethers; Platelet Activating Factor; Rats; Triazoles

1994
Protection from BB rat diabetes by the platelet-activating factor inhibitor BN50730.
    Autoimmunity, 1993, Volume: 16, Issue:4

    Topics: Age Factors; Animals; Autoimmune Diseases; Azepines; Diabetes Mellitus, Type 1; Insulin; Islets of Langerhans; Male; Platelet Activating Factor; Rats; Rats, Inbred BB; Tetrazoles; Thienopyridines; Thyroid Gland; Thyroiditis, Autoimmune; Triazoles

1993
A flow cytometric assay reveals an enhancement of phagocytosis by platelet activating factor in murine peritoneal macrophages.
    Cellular immunology, 1994, Volume: 156, Issue:2

    Topics: Animals; Azepines; Calcium; Female; Flow Cytometry; In Vitro Techniques; Latex; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Phagocytosis; Phospholipid Ethers; Platelet Activating Factor; Triazoles

1994
Lipopolysaccharide-induced pleural neutrophil accumulation depends on marrow neutrophils and platelet-activating factor.
    European journal of pharmacology, 1994, Apr-04, Volume: 270, Issue:2-3

    Topics: Animals; Azepines; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cell Movement; Dihydropyridines; Escherichia coli; Injections; Kinetics; Leukocyte Count; Lipopolysaccharides; Male; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pleura; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thorax; Triazoles

1994
Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets.
    The Biochemical journal, 1994, Jul-15, Volume: 301 ( Pt 2)

    Topics: Animals; Azepines; Blood Platelets; Calcium; Cations, Divalent; Indoles; Inositol 1,4,5-Trisphosphate; Ionomycin; Maleimides; Manganese; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Rabbits; Signal Transduction; Triazoles

1994
Hyperalgesia induced by Bothrops jararaca venom in rats: role of eicosanoids and platelet activating factor (PAF).
    Toxicon : official journal of the International Society on Toxinology, 1994, Volume: 32, Issue:4

    Topics: Animals; Azepines; Bothrops; Crotalid Venoms; Dexamethasone; Diterpenes; Dose-Response Relationship, Drug; Eicosanoids; Fibrinolytic Agents; Ginkgolides; Hyperalgesia; Indomethacin; Lactones; Male; Platelet Activating Factor; Rats; Rats, Wistar; Triazoles

1994
Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog.
    Xenobiotica; the fate of foreign compounds in biological systems, 1994, Volume: 24, Issue:4

    Topics: Animals; Antipyrine; Azepines; Cytochrome P-450 Enzyme System; Dogs; Half-Life; Male; Metabolic Clearance Rate; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases, N-Demethylating; Platelet Activating Factor; Regression Analysis; Triazoles; Trimethadione

1994
The effect of a free radical scavenger and platelet-activating factor antagonist on FFA accumulation in post-ischemic canine brain.
    Neurochemical research, 1994, Volume: 19, Issue:4

    Topics: Animals; Arachidonic Acids; Azepines; Brain; Dimethyl Sulfoxide; Dogs; Fatty Acids, Nonesterified; Free Radical Scavengers; In Vitro Techniques; Ischemic Attack, Transient; Oleic Acids; Palmitic Acids; Platelet Activating Factor; Reperfusion; Stearic Acids; Triazoles

1994
Histologic and ultrastructural changes after large-colon torsion, with and without use of a specific platelet-activating factor antagonist (WEB 2086), in ponies.
    American journal of veterinary research, 1994, Volume: 55, Issue:5

    Topics: Animals; Azepines; Colon; Colonic Diseases; Edema; Epithelium; Female; Horse Diseases; Horses; Intestinal Mucosa; Male; Microscopy, Electron; Necrosis; Neutrophils; Platelet Activating Factor; Torsion Abnormality; Triazoles

1994
[Lung 3H-thymidine incorporation in monocrotaline (MCT)-treated rats--role of platelet-activating factor (PAF)].
    Nihon Kyobu Shikkan Gakkai zasshi, 1994, Volume: 32, Issue:5

    Topics: Animals; Azepines; DNA; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thymidine; Triazoles

1994
Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

    Topics: Antibodies, Monoclonal; Antigens, CD; Azepines; Biological Assay; CD11 Antigens; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Hypoxia; Cells, Cultured; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Kinetics; Neutrophils; Oleic Acid; Oleic Acids; Platelet Activating Factor; Recombinant Proteins; Stearic Acids; Time Factors; Triazoles; Umbilical Veins

1993
Platelet-activating factor inhibits excitatory transmission in rat neostriatum.
    Neuroscience letters, 1993, Jun-11, Volume: 155, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Azepines; Glutamates; Glutamic Acid; Neostriatum; Neural Inhibition; Platelet Activating Factor; Platelet Membrane Glycoproteins; Quinoxalines; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1993
Hyperacute rejection in an ex vivo model of renal xenografting. Role of the mediator response and its pharmacologic manipulation by the specific platelet-activating factor antagonist WEB 2086BS.
    Transplantation, 1994, Volume: 57, Issue:3

    Topics: Adult; Animals; Antibodies, Heterophile; Antibody Formation; Azepines; Female; Graft Rejection; Hematocrit; Hemoglobins; Humans; Inflammation; Kidney; Kidney Transplantation; Male; Perfusion; Platelet Activating Factor; Pressure; Prostaglandins; Swine; Transplantation, Heterologous; Triazoles; Tumor Necrosis Factor-alpha; Vascular Resistance

1994
Binding and metabolism of platelet-activating factor (PAF) by isolated rat type II pneumonocytes.
    Archives of biochemistry and biophysics, 1994, Feb-01, Volume: 308, Issue:2

    Topics: Animals; Azepines; Biotransformation; Cells, Cultured; Kinetics; Lung; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1994
Interactions between synthesis of platelet-activating factor and leukotriene B4 in isolated human polymorphonuclear leukocytes.
    Inflammation, 1993, Volume: 17, Issue:6

    Topics: Arachidonate 5-Lipoxygenase; Azepines; Calcimycin; Chemotaxis, Leukocyte; Drug Interactions; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotriene B4; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1993
Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation.
    Nature, 1994, Jan-13, Volume: 367, Issue:6459

    Topics: Action Potentials; Animals; Azepines; Diterpenes; Ginkgolides; Hippocampus; In Vitro Techniques; Lactones; Long-Term Potentiation; Male; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrazoles; Thienopyridines; Triazoles

1994
A comparison of the actions of platelet activating factor (PAF) antagonists WEB 2170 and WEB 2086 in the horse.
    Journal of veterinary pharmacology and therapeutics, 1993, Volume: 16, Issue:4

    Topics: Animals; Azepines; Capillary Permeability; Dose-Response Relationship, Drug; Histamine; Horses; Leukocyte Count; Male; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Skin; Triazoles

1993
In vitro modulation of interleukin-1 beta secretion by cultured rat doxorubicin-stimulated whole glomeruli and dissociated mesangial glomerular cells.
    Immunology, 1994, Volume: 81, Issue:1

    Topics: Animals; Azepines; Cells, Cultured; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Glomerular Mesangium; Interleukin-1; Kidney Glomerulus; Kinetics; Lipopolysaccharides; Male; Molecular Weight; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles

1994
Effect of a platelet-activating factor antagonist, WEB 2086, on inhibition of active oxygen generation in human polymorphonuclear leukocytes.
    Pharmacology, 1994, Volume: 48, Issue:2

    Topics: Azepines; Free Radicals; Humans; Hydroxyl Radical; Neutrophils; Platelet Activating Factor; Superoxides; Triazoles

1994
Platelet-activating factor is a messenger in the electroconvulsive shock-induced transcriptional activation of c-fos and zif-268 in hippocampus.
    Journal of neuroscience research, 1994, Volume: 37, Issue:1

    Topics: Animals; Azepines; Base Sequence; DNA-Binding Proteins; Early Growth Response Protein 1; Electroshock; Gene Expression Regulation; Hippocampus; Immediate-Early Proteins; Male; Microsomes; Molecular Sequence Data; Neuronal Plasticity; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Seizures; Synaptic Membranes; Tetrazoles; Thienopyridines; Transcription Factors; Transcription, Genetic; Triazoles; Zinc Fingers

1994
Gastrointestinal physiology-regulated dogs: utilization of a bioavailability study of a new thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]-diazepine, an antagonist of platelet-activating factor, and its preparations.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:1

    Topics: Administration, Oral; Animals; Atropine; Azepines; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Dosage Forms; Humans; Injections, Intravenous; Intestinal Absorption; Male; Pentagastrin; Platelet Activating Factor; Solubility; Tablets; Triazoles

1994
Platelet activating factor impairs pressor responses to noradrenaline in the anaesthetized rat but does not mediate endotoxin-induced hyporeactivity.
    Circulatory shock, 1994, Volume: 42, Issue:1

    Topics: Anesthesia; Animals; Azepines; Blood Circulation; Blood Pressure; Endotoxins; Male; Norepinephrine; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles

1994
Effect of the platelet-activating factor antagonist BN 50739 and its diluents on mitochondrial respiration and membrane lipids during and following cerebral ischemia.
    Journal of neurochemistry, 1994, Volume: 62, Issue:5

    Topics: Animals; Azepines; Brain; Fatty Acids, Nonesterified; Intracellular Membranes; Ischemic Attack, Transient; Lipid Peroxidation; Male; Membrane Lipids; Mitochondria; Oxygen Consumption; Phospholipids; Platelet Activating Factor; Prosencephalon; Rats; Rats, Sprague-Dawley; Triazoles

1994
Role of platelet-activating factor (PAF) in oxygen radical-induced cardiac dysfunction.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:2

    Topics: Animals; Azepines; Free Radicals; Fumarates; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Platelet Activating Factor; Reactive Oxygen Species; Superoxide Dismutase; Triazoles

1994
Rat liver blood flow after ischemia and reperfusion. The effects of the platelet-activating factor antagonist WEB-2170 and of removing circulating leukocytes.
    Transplantation, 1994, May-27, Volume: 57, Issue:10

    Topics: Animals; Azepines; Liver; Liver Circulation; Male; Neutrophils; Oxyhemoglobins; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Triazoles; Vinblastine

1994
Mast cell activation augments gastric mucosal injury through a leukotriene-dependent mechanism.
    The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 1

    Topics: Animals; Azepines; Blood Pressure; Chymases; Dexamethasone; Gastric Mucosa; Leukotriene Antagonists; Leukotrienes; Male; Mast Cells; Nippostrongylus; Platelet Activating Factor; Propionates; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene; Reference Values; Regional Blood Flow; Serine Endopeptidases; Stomach; Strongylida Infections; Triazoles

1994
Development of radioimmunoassay for the novel platelet activating factor receptor antagonist, E6123, and its application to pharmacokinetics in laboratory animals.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:2

    Topics: Animals; Azepines; Biological Availability; Chromatography, High Pressure Liquid; Cross Reactions; Dogs; Guinea Pigs; Haptens; Immune Sera; Macaca mulatta; Male; Platelet Activating Factor; Rabbits; Radioimmunoassay; Sensitivity and Specificity; Serum Albumin, Bovine; Spectrophotometry, Ultraviolet; Triazoles

1994
The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival.
    Transplantation, 1993, Volume: 56, Issue:4

    Topics: Animals; Azepines; Cyclosporine; Dogs; Drug Therapy, Combination; Graft Survival; Immunosuppression Therapy; Kidney Transplantation; Platelet Activating Factor; Survival Analysis; Transplantation, Homologous; Triazoles

1993
Pharmacokinetics of a new thienodiazepine platelet activating factor receptor antagonist (E6123) in laboratory animals. Is there a metabolic polymorphism in the rhesus monkey?
    Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:6

    Topics: Animals; Azepines; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Dogs; Guinea Pigs; Macaca mulatta; Male; Platelet Activating Factor; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Triazoles

1993
Metabolic polymorphism of E6123 in rhesus monkey.
    Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:6

    Topics: Animals; Azepines; Erythrocytes; Feces; Hydrogen-Ion Concentration; Kinetics; Macaca mulatta; Male; Platelet Activating Factor; Polymorphism, Genetic; Triazoles

1993
Effect of platelet-activating factor (PAF) receptor blockers on smooth muscle cell replication in vitro and allograft arteriosclerosis in vivo.
    Transplant international : official journal of the European Society for Organ Transplantation, 1993, Volume: 6, Issue:5

    Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Autoradiography; Azepines; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Fibroblasts; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred WF; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Transplantation, Homologous; Triazoles

1993
Platelet activating factor and histamine effects in synovial blood flow evaluated by laser-Doppler flowmetry.
    The Journal of rheumatology, 1993, Volume: 20, Issue:8

    Topics: Animals; Azepines; Female; Histamine; Laser-Doppler Flowmetry; Male; Platelet Activating Factor; Rabbits; Regional Blood Flow; Synovial Membrane; Triazoles; Vasoconstriction

1993
Platelet-activating-factor-induced augmentation of production of eosinophil-lineage cells in hematopoietic precursor cells obtained from human umbilical cord blood.
    International archives of allergy and immunology, 1993, Volume: 102, Issue:4

    Topics: Azepines; Cell Differentiation; Cells, Cultured; Cytokines; Enzyme-Linked Immunosorbent Assay; Eosinophils; Fetal Blood; Gene Expression; Hematopoietic Stem Cells; Humans; Interleukin-3; Platelet Activating Factor; Polymerase Chain Reaction; RNA, Messenger; Triazoles

1993
PAF activation of a voltage-gated R-type Ca2+ channel in human and canine aortic endothelial cells.
    British journal of pharmacology, 1993, Volume: 110, Issue:2

    Topics: Azepines; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Endothelium, Vascular; Fura-2; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Ion Channel Gating; Isradipine; Male; Platelet Activating Factor; Potassium; Triazoles

1993
Partial agonist effect of the platelet-activating factor receptor antagonists, WEB 2086 and WEB 2170, in the rat perfused heart.
    British journal of pharmacology, 1993, Volume: 110, Issue:2

    Topics: Animals; Azepines; Heart; In Vitro Techniques; Leukotrienes; Perfusion; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Vasoconstriction; Vasodilation

1993
Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist.
    Journal of lipid mediators, 1993, Volume: 8, Issue:1

    Topics: Animals; Antioxidants; Azepines; Blood Glucose; Blood Platelets; Cattle; Diabetes Mellitus, Experimental; Free Radical Scavengers; Humans; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Mitochondria, Heart; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock, Septic; Superoxides; Sympathomimetics; Thiazoles; Thiobarbituric Acid Reactive Substances; Triazoles

1993
Prevention of chloroquine-induced electroretinographic damage by a new platelet-activating factor antagonist, BN 50730.
    Ophthalmic research, 1993, Volume: 25, Issue:5

    Topics: Animals; Azepines; Chloroquine; Dark Adaptation; Electroretinography; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Tetrazoles; Thienopyridines; Triazoles

1993
Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet-activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the brown Norway rat.
    International archives of allergy and immunology, 1994, Volume: 103, Issue:1

    Topics: Allergens; Animals; Arachidonate 5-Lipoxygenase; Asthma; Azepines; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Hypersensitivity, Immediate; Male; Methysergide; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred BN; Serotonin; Triazoles

1994
Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin.
    Biochemical and biophysical research communications, 1993, Dec-15, Volume: 197, Issue:2

    Topics: Animals; Azepines; Calcium; Chloride Channels; Cloning, Molecular; Endotoxins; Escherichia coli; Female; Guinea Pigs; L Cells; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Membrane Potentials; Mice; Neutrophils; Oocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction; Superoxides; Triazoles; Tumor Necrosis Factor-alpha; Xenopus laevis

1993
Differential sensitivity of mouse strains to platelet activating factor-induced vasopermeability and mortality: effect of antagonists.
    Journal of lipid mediators, 1993, Volume: 8, Issue:3

    Topics: Animals; Azepines; Capillary Permeability; Coloring Agents; Diterpenes; Evans Blue; Ginkgolides; Lactones; Mice; Mice, Inbred A; Mice, Inbred BALB C; Platelet Activating Factor; Species Specificity; Triazoles

1993
Platelet activating factor (PAF) enhances mitosis in preimplantation mouse embryos.
    Reproduction, fertility, and development, 1993, Volume: 5, Issue:3

    Topics: Animals; Azepines; Blastocyst; Cell Count; Culture Techniques; Female; Mice; Mitosis; Mitotic Index; Platelet Activating Factor; Triazoles

1993
Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines.
    Biochemical and biophysical research communications, 1993, Dec-30, Volume: 197, Issue:3

    Topics: Azepines; B-Lymphocytes; Calcium; Cell Line; Cycloheximide; Dactinomycin; Gene Expression; Humans; Ionomycin; Kinetics; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Time Factors; Transcription, Genetic; Transforming Growth Factor beta; Triazoles; Tumor Cells, Cultured; Up-Regulation

1993
Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro.
    Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:7

    Topics: Alkaloids; Animals; Azepines; Benzylisoquinolines; Binding Sites; Cattle; Cerebral Arteries; Isoquinolines; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetrahydroisoquinolines; Triazoles

1993
Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor.
    The Journal of laboratory and clinical medicine, 1994, Volume: 123, Issue:1

    Topics: Animals; Azepines; Endotoxins; Lipopolysaccharides; Lung; Male; Neutrophils; Peroxidase; Platelet Activating Factor; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Triazoles; Tumor Necrosis Factor-alpha

1994
Tumour necrosis factor and endotoxin synergistically activate intestinal phospholipase A2 in mice. Role of endogenous platelet activating factor and effect of exogenous platelet activating factor.
    Gut, 1994, Volume: 35, Issue:2

    Topics: Animals; Azepines; Drug Synergism; Endotoxins; Enzyme Activation; Intestines; Lipopolysaccharides; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Quinolinium Compounds; Stimulation, Chemical; Triazoles; Tumor Necrosis Factor-alpha

1994
Compounds biologically similar to platelet activating factor are present in stored blood components.
    Lipids, 1993, Volume: 28, Issue:5

    Topics: Azepines; Blood Preservation; Gas Chromatography-Mass Spectrometry; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Platelet Activating Factor; Radioimmunoassay; Triazoles

1993
Triazolobenzodiazepines: a new class of stimulators of tissue-type plasminogen activator synthesis in human endothelial cells.
    Biochemical pharmacology, 1993, Jul-06, Volume: 46, Issue:1

    Topics: Benzodiazepines; Cells, Cultured; Endothelium, Vascular; Humans; Plasminogen Activator Inhibitor 1; Platelet Activating Factor; RNA, Messenger; Structure-Activity Relationship; Tissue Plasminogen Activator; Triazoles

1993
Experimental otitis media with effusion induced by platelet activating factor.
    The Annals of otology, rhinology, and laryngology, 1993, Volume: 102, Issue:8 Pt 1

    Topics: Animals; Azepines; Chinchilla; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Otitis Media with Effusion; Platelet Activating Factor; Temporal Bone; Time Factors; Triazoles

1993
Involvement of platelet-activating factor (PAF) in endotoxin- or ischaemia-induced intestinal hyperpermeability in the rat.
    Journal of lipid mediators, 1993, Volume: 7, Issue:1

    Topics: Allopurinol; Animals; Azepines; Endotoxins; Free Radical Scavengers; Intestinal Mucosa; Intestines; Male; Permeability; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Thienopyridines; Triazoles; Xanthine Oxidase

1993
Platelet-activating factor induces collagenase expression in corneal epithelial cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Sep-15, Volume: 90, Issue:18

    Topics: Animals; Azepines; Base Sequence; Blotting, Northern; Collagenases; Cornea; Cycloheximide; Epithelium; Gene Expression; Genes, fos; Genes, jun; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Organ Culture Techniques; Platelet Activating Factor; Rabbits; RNA, Messenger; Tetrazoles; Thienopyridines; Triazoles

1993
Platelet-activating factor-induced human eosinophil transendothelial migration: evidence for a dynamic role of the endothelium.
    American journal of respiratory cell and molecular biology, 1993, Volume: 8, Issue:1

    Topics: Azepines; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Eosinophils; Humans; Leukotriene B4; Microscopy, Electron; Neutrophils; Platelet Activating Factor; Triazoles

1993
Role of PAF in the allergic pleurisy caused by ovalbumin in actively sensitized rats.
    Journal of leukocyte biology, 1993, Volume: 53, Issue:1

    Topics: Analysis of Variance; Animals; Azepines; Chemotactic Factors, Eosinophil; Diterpenes; Drug Hypersensitivity; Eosinophils; Female; Freund's Adjuvant; Ginkgolides; Inflammation; Lactones; Leukocyte Count; Male; Oligopeptides; Ovalbumin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pleurisy; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1993
Mediators of the hypotensive response to increased renal perfusion in rabbits.
    Hypertension (Dallas, Tex. : 1979), 1993, Volume: 21, Issue:2

    Topics: Animals; Azepines; Blood Pressure; Diuresis; Enalaprilat; Hemodynamics; Hypotension; Indomethacin; Natriuresis; Perfusion; Platelet Activating Factor; Pressure; Rabbits; Renal Circulation; Triazoles

1993
Pharmacological characterization of a receptor for platelet-activating factor on guinea pig peritoneal macrophages using [3H]apafant, a selective and competitive platelet-activating factor antagonist: evidence that the noncompetitive behavior of apafant i
    Molecular pharmacology, 1993, Volume: 43, Issue:2

    Topics: Animals; Azepines; Binding, Competitive; Guinea Pigs; In Vitro Techniques; Kinetics; Macrophages; Male; Peritoneal Cavity; Platelet Activating Factor; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Burst; Triazoles

1993
Role of platelet-activating factor in hypotension and platelet activation induced by infusion of thrombolytic agents in rabbits.
    Circulation research, 1993, Volume: 72, Issue:3

    Topics: Animals; Azepines; Female; Hypotension; Male; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Quinolines; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Streptokinase; Tissue Plasminogen Activator; Triazoles

1993
Platelet-activating factor-induced enhancement of superoxide anion generation in guinea-pigs.
    European journal of pharmacology, 1993, Feb-23, Volume: 232, Issue:1

    Topics: Animals; Azepines; Guinea Pigs; Injections, Intravenous; Luminescent Measurements; Macrophages, Alveolar; Male; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Thromboxane; Superoxides; Thromboxane A2; Triazoles

1993
PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances.
    Prostaglandins, leukotrienes, and essential fatty acids, 1993, Volume: 48, Issue:3

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Disease Models, Animal; Diterpenes; Eicosanoids; Female; Ginkgolides; Lactones; Masoprocol; Mice; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock; Species Specificity; Triazoles

1993
Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils.
    Life sciences, 1993, Volume: 52, Issue:20

    Topics: Animals; Azepines; Binding, Competitive; Cell Membrane; Cholera Toxin; Enzyme Activation; Eosinophils; GTP Phosphohydrolases; Guinea Pigs; Male; Nerve Tissue Proteins; Pertussis Toxin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinases; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Substrate Specificity; Triazoles; Virulence Factors, Bordetella

1993
Mechanism and regulation of neutrophil priming by platelet-activating factor.
    Journal of cellular physiology, 1993, Volume: 156, Issue:1

    Topics: Adult; Amiloride; Azepines; Calcium; Chelating Agents; Diacylglycerol Kinase; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphotransferases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyrimidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Thiazoles; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella

1993
Meningocortical lesion increases expression of the cholecystokinin gene in rat cerebral cortex: evidence for the involvement of platelet-activating factor (PAF).
    Brain research. Molecular brain research, 1993, Volume: 18, Issue:4

    Topics: Animals; Azepines; Cerebral Cortex; Cholecystokinin; Gene Expression Regulation; Lipoxygenase; Male; Meninges; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1993
Transcriptional modulation of platelet-activating factor receptor gene expression by cyclic AMP.
    The Journal of biological chemistry, 1993, Aug-15, Volume: 268, Issue:23

    Topics: Animals; Azepines; Bucladesine; Calcium; Cell Membrane; Cells, Cultured; Cricetinae; Cyclic AMP; Cycloheximide; Dinoprostone; Flow Cytometry; Gene Expression Regulation; Humans; Kinetics; Monocytes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Transcription, Genetic; Triazoles

1993
Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis.
    Gastroenterology, 1993, Volume: 105, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Azepines; Benzopyrans; Blood Pressure; Cell Adhesion; Cell Communication; Cell Movement; Leukocytes; Leukotriene B4; Mesenteric Veins; Microscopy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Quinacrine; Rats; Rats, Inbred WKY; Regional Blood Flow; Triazoles; Venules

1993
Platelet activating factor-induced microvascular permeability increases in the cat hindlimb.
    Circulatory shock, 1993, Volume: 41, Issue:1

    Topics: Animals; Azepines; Capillary Permeability; Cats; Cimetidine; Diphenhydramine; Endothelium, Vascular; Hindlimb; Histamine; Isoproterenol; Leukocyte Count; Leukocytes; Platelet Activating Factor; Triazoles

1993
Bronchopulmonary responses to endothelin-1 in sensitized and challenged guinea-pigs: role of cyclooxygenase metabolites and platelet-activating factor.
    Fundamental & clinical pharmacology, 1993, Volume: 7, Issue:6

    Topics: Aerosols; Animals; Azepines; Bronchi; Disease Models, Animal; Endothelins; Glycopeptides; Guinea Pigs; Immunization; Indomethacin; Lung; Male; Neprilysin; Ovalbumin; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Respiratory Function Tests; Tetrazoles; Thienopyridines; Time Factors; Triazoles

1993
Autocrine amplification of PAF-acether formation in immunologically activated murine macrophages.
    Journal of leukocyte biology, 1993, Volume: 54, Issue:4

    Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Animals; Azepines; Cells, Cultured; Chromatography, High Pressure Liquid; Diterpenes; Female; Ginkgolides; Kinetics; Lactones; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mycobacterium bovis; Platelet Activating Factor; Triazoles

1993
Effect of 5-lipoxygenase and cyclooxygenase blockade on porcine hemodynamics during continuous infusion of platelet-activating factor.
    Prostaglandins, leukotrienes, and essential fatty acids, 1993, Volume: 49, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Blood; Calcimycin; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Hemodynamics; Hypertension, Pulmonary; In Vitro Techniques; Indomethacin; Infusions, Intra-Arterial; Leukotriene B4; Lipoxygenase Inhibitors; Naphthoquinones; ortho-Aminobenzoates; Platelet Activating Factor; Swine; Thromboxane B2; Triazoles

1993
Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo.
    Prostaglandins, leukotrienes, and essential fatty acids, 1993, Volume: 49, Issue:2

    Topics: Animals; Asthma; Azepines; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Leukotriene Antagonists; Leukotrienes; Male; Platelet Activating Factor; Pyridines; Pyrimidinones; Respiratory Hypersensitivity; Tetrazoles; Triazoles

1993
Human platelets secrete chemotactic activity for eosinophils.
    Blood, 1993, Jan-01, Volume: 81, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Calcium; Chemotactic Factors; Chemotaxis, Leukocyte; Cytoplasmic Granules; Cytosol; Eosinophils; Humans; Platelet Activating Factor; Platelet Factor 4; Platelet Storage Pool Deficiency; Prostaglandin Endoperoxides; Thromboxane A2; Triazoles

1993
Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086.
    American journal of veterinary research, 1993, Volume: 54, Issue:2

    Topics: Anesthesia, Intravenous; Animals; Azepines; Blood Pressure; Clonixin; Female; Horses; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Triazoles

1993
Role of platelet-activating factor in polymorphonuclear neutrophil recruitment in reperfused ischemic rabbit heart.
    The American journal of pathology, 1993, Volume: 142, Issue:2

    Topics: Animals; Azepines; Cell Movement; Female; Heart; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Neutrophils; Platelet Activating Factor; Quinolines; Rabbits; Risk Factors; Triazoles

1993
Roles of platelet-activating factor, thromboxane A2, ADP and thrombin in thrombogenesis in the guinea pig.
    European journal of pharmacology, 1993, Feb-16, Volume: 231, Issue:3

    Topics: Adenosine Diphosphate; Animals; Azepines; Biphenyl Compounds; Guinea Pigs; Heptanoic Acids; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Ticlopidine; Triazoles

1993
Platelet-activating factor and the vascular effects of zymosan in rats.
    European journal of pharmacology, 1993, Feb-09, Volume: 231, Issue:2

    Topics: Animals; Azepines; Blood Pressure; Capillary Permeability; Female; Hematocrit; Hemodynamics; Iodine Radioisotopes; Male; Muscle, Smooth, Vascular; Platelet Activating Factor; Rats; Rats, Wistar; Thiazoles; Thiazolidines; Triazoles; Zymosan

1993
Effect of inhaled lyso-platelet-activating factor on airway microvascular leakage in the guinea pig.
    Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 74, Issue:3

    Topics: Administration, Inhalation; Aerosols; Airway Resistance; Animals; Azepines; Blood Pressure; Bronchoconstriction; Capillary Permeability; Dose-Response Relationship, Drug; Evans Blue; Female; Guinea Pigs; Injections, Intravenous; Lysophosphatidylcholines; Platelet Activating Factor; Respiratory Function Tests; Respiratory System; Triazoles

1993
The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit.
    The American review of respiratory disease, 1993, Volume: 147, Issue:5

    Topics: Airway Resistance; Anaphylaxis; Animals; Azepines; Basophil Degranulation Test; Blood Pressure; Chlorpheniramine; Cimetidine; Histamine; Immunoglobulin E; Leukocyte Count; Lung Compliance; Platelet Activating Factor; Rabbits; Serotonin; Tidal Volume; Triazoles

1993
Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation.
    The American journal of pathology, 1993, Volume: 142, Issue:5

    Topics: Animals; Azepines; Calcium; Ceruletide; Male; Osmolar Concentration; Pancreas; Pancreatitis; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles

1993
Effect of a specific platelet-activating factor antagonist on cardiovascular and peripheral cellular responses to colonic ischemia and reperfusion in anesthetized ponies.
    American journal of veterinary research, 1993, Volume: 54, Issue:3

    Topics: Analysis of Variance; Animals; Azepines; Blood Pressure; Body Temperature; Cardiac Output; Colon; Female; Heart Rate; Hemodynamics; Horses; Ischemia; Leukocyte Count; Male; Orchiectomy; Platelet Activating Factor; Pulmonary Circulation; Reperfusion; Triazoles; Vascular Resistance

1993
Involvement of platelet-activating factor in death following anaphylactic shock in boosted and in unboosted mice.
    European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1

    Topics: Anaphylaxis; Animals; Azepines; Immunization, Secondary; Immunoglobulin E; Immunoglobulin G; Male; Mice; Ovalbumin; Platelet Activating Factor; Triazoles; Vaccination

1993
Platelet-activating factor preferentially stimulates the phospholipase A2/cyclooxygenase cascade in the rabbit cornea.
    Current eye research, 1995, Volume: 14, Issue:9

    Topics: Animals; Arachidonic Acid; Azepines; Cornea; Dinoprostone; Female; In Vitro Techniques; Male; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rabbits; Thienopyridines; Triazoles

1995
Signaling by E-selectin and ICAM-1 induces endothelial tissue factor production via autocrine secretion of platelet-activating factor and tumor necrosis factor alpha.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 1995, Volume: 15, Issue:9

    Topics: Antigen-Antibody Reactions; Azepines; Cells, Cultured; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction; Stimulation, Chemical; Thromboplastin; Triazoles; Tumor Necrosis Factor-alpha

1995
Plasma mediated neutrophil stimulation during coronary angioplasty: autocrine effect of platelet activating factor.
    British heart journal, 1995, Volume: 74, Issue:6

    Topics: Angioplasty, Balloon, Coronary; Azepines; CD18 Antigens; Cells, Cultured; Coronary Circulation; Diterpenes; Femoral Artery; Femoral Vein; Ginkgolides; Humans; Lactones; Myocardial Ischemia; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Superoxides; Triazoles

1995
[The roles of platelet activating factor in intestinal mucosal barrier injury after burn].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 1995, Volume: 33, Issue:7

    Topics: Animals; Azepines; Burns; Female; Intestinal Mucosa; Male; Membrane Potentials; Peroxidase; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles

1995
Role of PAF in the late airway microvascular leakage induced by antigen in IgE-sensitized rat.
    Fundamental & clinical pharmacology, 1995, Volume: 9, Issue:4

    Topics: Administration, Oral; Animals; Antigens; Azepines; Bronchi; Capillary Permeability; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Immunoglobulin E; Injections, Intravenous; Male; Methysergide; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Specific Pathogen-Free Organisms; Thienopyridines; Trachea; Triazoles

1995
Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor.
    Biochemical and biophysical research communications, 1996, Jan-26, Volume: 218, Issue:3

    Topics: Azepines; Calcium; Ion Channel Gating; Membrane Potentials; Neuroblastoma; Neurons; Platelet Activating Factor; Potassium Channels; Triazoles; Tumor Cells, Cultured

1996
Platelet-activating factor mediates pulmonary macromolecular leak following intestinal ischemia-reperfusion.
    The Journal of surgical research, 1996, Feb-01, Volume: 60, Issue:2

    Topics: Animals; Azepines; Capillary Permeability; Hemodynamics; Intestines; Ischemia; Lung; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Triazoles

1996
Alkyl-PAF and acyl-PAF human neutrophil priming for enhanced fMLP- and rC5a-induced superoxide anion production.
    Journal of leukocyte biology, 1996, Volume: 59, Issue:2

    Topics: Adrenergic beta-Antagonists; Amino Acid Sequence; Anions; Azepines; Complement C5a; Drug Synergism; Female; Humans; Male; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidylcholines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Recombinant Proteins; Superoxides; Triazoles

1996
Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity.
    Toxicology letters, 1996, Volume: 84, Issue:2

    Topics: 1-Naphthylisothiocyanate; Animals; Azepines; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Liver; Male; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles

1996
Formation of a highly stable complex between BN 50730 [tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4',3'-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4] and the platelet-activating factor receptor in ra
    Biochemical pharmacology, 1996, Jan-26, Volume: 51, Issue:2

    Topics: Animals; Azepines; Binding Sites; Blood Platelets; Cell Membrane; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles

1996
PAF-induced airways hyperreactivity is modulated by mast cells in mice.
    American journal of respiratory cell and molecular biology, 1996, Volume: 14, Issue:5

    Topics: Acetylcholine; Analysis of Variance; Animals; Azepines; Blood Cell Count; Bone Marrow Transplantation; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Evans Blue; Hematocrit; Lung; Male; Mast Cells; Mice; Mice, Inbred AKR; Mice, Mutant Strains; Nedocromil; Permeability; Platelet Activating Factor; Prostaglandin D2; Species Specificity; Trachea; Triazoles

1996
Role of platelet-activating factor in pathogenesis of galactosamine-lipopolysaccharide-induced liver injury.
    Digestive diseases and sciences, 1996, Volume: 41, Issue:5

    Topics: Animals; Azepines; Cell Adhesion; Cells, Cultured; Chemical and Drug Induced Liver Injury; Endothelium; Escherichia coli; Galactosamine; Lipopolysaccharides; Liver; Male; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles; Tumor Necrosis Factor-alpha

1996
Mutations of two adjacent amino acids generate inactive and constitutively active forms of the human platelet-activating factor receptor.
    The Journal of biological chemistry, 1996, Apr-05, Volume: 271, Issue:14

    Topics: Amino Acid Sequence; Animals; Azepines; Base Sequence; Cells, Cultured; Chlorocebus aethiops; CHO Cells; Cricetinae; DNA Primers; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Membrane Glycoproteins; Molecular Sequence Data; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles

1996
Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production.
    Biochemical and biophysical research communications, 1996, Feb-27, Volume: 219, Issue:3

    Topics: Amino Acid Sequence; Animals; Aspartic Acid; Azepines; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; CHO Cells; Conserved Sequence; Cricetinae; GTP-Binding Proteins; Inositol Phosphates; Kinetics; Mutagenesis, Site-Directed; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Point Mutation; Protein Conformation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Transfection; Triazoles

1996
Augmentation of tumor metastasis by platelet-activating factor.
    Cancer research, 1996, Jun-01, Volume: 56, Issue:11

    Topics: Animals; Antineoplastic Agents; Azepines; Female; Interleukin-1; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Platelet Activating Factor; Triazoles; Tumor Necrosis Factor-alpha

1996
Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils.
    Biochemical pharmacology, 1996, Jul-12, Volume: 52, Issue:1

    Topics: Adrenal Glands; Alkaloids; Animals; Azepines; Calcium; Calcium Channel Blockers; Cattle; Chromaffin Granules; Enzyme Inhibitors; Imidazoles; Ion Transport; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Triazoles

1996
Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi.
    Biochemical and biophysical research communications, 1996, Jun-25, Volume: 223, Issue:3

    Topics: Animals; Azepines; Cell Differentiation; Kinetics; Microscopy, Electron; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Trypanosoma cruzi

1996
Protective effect of a platelet-activating factor antagonist (WEB-2086) in postischemic renal failure.
    Annals of vascular surgery, 1996, Volume: 10, Issue:1

    Topics: Acute Kidney Injury; Animals; Azepines; Disease Models, Animal; Diuresis; Female; Ischemia; Kidney; Kidney Function Tests; Male; Necrosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Triazoles

1996
Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages.
    American journal of veterinary research, 1996, Volume: 57, Issue:4

    Topics: Adenosine Diphosphate Ribose; Aluminum Chloride; Aluminum Compounds; Analysis of Variance; Animals; Azepines; Bronchoalveolar Lavage; Cell Survival; Cells, Cultured; Chlorides; GTP-Binding Proteins; Inositol; Inositol Phosphates; L-Lactate Dehydrogenase; Macrophages, Alveolar; NAD; Pertussis Toxin; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Sodium Fluoride; Swine; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella

1996
Rapid tracheal infusion of surfactant versus bolus instillation in rabbits: effects on oxygenation, blood pressure and surfactant distribution.
    Biology of the neonate, 1996, Volume: 69, Issue:2

    Topics: Animals; Azepines; Blood Pressure; Lung; Oxygen; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Surface-Active Agents; Tissue Distribution; Trachea; Triazoles

1996
Microvascular mechanisms of histamine-induced potentiation of leukocyte adhesion evoked by chemoattractants.
    British journal of pharmacology, 1995, Volume: 116, Issue:8

    Topics: Amino Acid Sequence; Animals; Azepines; Chemotactic Factors; Drug Synergism; Female; Histamine; Leukocytes; Leukotriene B4; Microcirculation; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rats; Rats, Wistar; Splanchnic Circulation; Triazoles

1995
Role for intracellular platelet-activating factor in the circulatory failure in a model of gram-positive shock.
    British journal of pharmacology, 1995, Volume: 116, Issue:8

    Topics: Acute Kidney Injury; Animals; Azepines; Cells, Cultured; Diterpenes; Ginkgolides; Hemodynamics; Lactones; Lipopolysaccharides; Lung; Male; Nitric Oxide Synthase; Nitrites; Norepinephrine; Plant Extracts; Platelet Activating Factor; Rats; Rats, Wistar; Shock, Septic; Streptomyces; Teichoic Acids; Triazoles; Tumor Necrosis Factor-alpha

1995
Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1996, Volume: 7, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azepines; Carbazoles; Clonixin; Endotoxins; Heparin; Horses; In Vitro Techniques; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinacrine; Thromboxane A2; Triazoles

1996
Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1996, Volume: 7, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin; Succinates; Sulfonamides; Thromboxane A2; Triazoles; Vasoconstrictor Agents

1996
Decrease of ciliary beat frequency by platelet activating factor: protective effect of ketotifen.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:5

    Topics: Animals; Azepines; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Ketotifen; Mucociliary Clearance; Platelet Activating Factor; Platelet Aggregation Inhibitors; Trachea; Triazoles

1996
Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero- 3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes.
    Brain research, 1996, Apr-09, Volume: 715, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Astrocytes; Azepines; Cells, Cultured; Citrulline; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stimulation, Chemical; Thienopyridines; Triazoles

1996
Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:4

    Topics: Animals; Azepines; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Diseases; Intestinal Mucosa; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Thiazoles; Triazoles

1996
Hypoxia induces PMN adherence to umbilical vein endothelium.
    Cardiovascular research, 1995, Volume: 30, Issue:6

    Topics: Antibodies, Monoclonal; Azepines; Cell Adhesion; Culture Techniques; Endothelium, Vascular; Humans; Hypoxia; Intercellular Adhesion Molecule-1; Microscopy, Electron, Scanning; Neutrophil Activation; Neutrophils; Oleic Acid; Oleic Acids; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Umbilical Veins

1995
Priming of eosinophil recruitment in vivo by LPS pretreatment.
    Journal of immunology (Baltimore, Md. : 1950), 1996, Aug-15, Volume: 157, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Azepines; CD18 Antigens; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Complement C5a, des-Arginine; Cycloheximide; Drug Synergism; Edema; Eosinophilia; Eosinophils; Female; Guinea Pigs; Immunoglobulin G; Interleukin 1 Receptor Antagonist Protein; Leukocyte Count; Leukotriene B4; Lipopolysaccharides; Lipoxygenase Inhibitors; Neutrophils; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; Protein Synthesis Inhibitors; Pyrans; Quinolones; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Recombinant Fusion Proteins; Sialoglycoproteins; Skin; Triazoles; Zymosan

1996
Platelet-activating factor is involved in the regulation of pathological leukocyte adhesion after liver transplantation.
    The Journal of surgical research, 1996, Feb-15, Volume: 61, Issue:1

    Topics: Animals; Azepines; Cell Adhesion; Endothelium, Vascular; Female; Leukocyte Count; Leukocytes; Liver; Liver Circulation; Liver Transplantation; Microcirculation; Microscopy, Fluorescence; Platelet Activating Factor; Postoperative Complications; Rats; Rats, Sprague-Dawley; Transaminases; Triazoles

1996
Helicobacter pylori stimulates gastric acid secretion via platelet activating factor.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1996, Volume: 47, Issue:1

    Topics: Aminopyrine; Animals; Anti-Ulcer Agents; Azepines; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Male; Omeprazole; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Thienopyridines; Triazoles

1996
Platelet-activating factor-induced inositol 1,4,5-trisphosphate generation in undifferentiated and differentiated U937 cells: role of tyrosine kinase.
    International journal of immunopharmacology, 1996, Volume: 18, Issue:3

    Topics: Azepines; Blotting, Western; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Humans; Inositol 1,4,5-Trisphosphate; Isoflavones; Monocytes; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Triazoles

1996
Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis.
    The Journal of biological chemistry, 1996, Sep-20, Volume: 271, Issue:38

    Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Azepines; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Conformation; Proto-Oncogene Proteins c-myc; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Transfection; Triazoles

1996
Platelet-activating factor modulates leukocyte adhesion to endothelium in ischemia-reperfusion.
    Microvascular research, 1996, Volume: 51, Issue:1

    Topics: Animals; Azepines; Cell Adhesion; Cheek; Cricetinae; Endothelium, Vascular; Leukocytes; Male; Mesocricetus; Mouth Mucosa; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reperfusion Injury; Triazoles

1996
Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium.
    Investigative ophthalmology & visual science, 1996, Volume: 37, Issue:10

    Topics: Amanitins; Animals; Azepines; Blotting, Northern; Cornea; Cyclic AMP; Dactinomycin; Epithelium; Ethers, Cyclic; Gene Expression Regulation, Enzymologic; GTP-Binding Proteins; Okadaic Acid; Organ Culture Techniques; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Synthesis Inhibitors; Rabbits; RNA, Messenger; Thienopyridines; Transcription, Genetic; Transcriptional Activation; Triazoles; Urokinase-Type Plasminogen Activator

1996
Eosinophil migration in response to three molecular species of platelet activating factor.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:6

    Topics: Adult; Azepines; Cell Movement; Cell Separation; Chemotaxis; Eosinophils; Humans; Platelet Activating Factor; Platelet Aggregation Inhibitors; Polycarboxylate Cement; Porosity; Structure-Activity Relationship; Triazoles

1996
Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis.
    Journal of lipid mediators and cell signalling, 1996, Volume: 13, Issue:1

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Azepines; C-Reactive Protein; Dinoprostone; Disease Models, Animal; Indenes; Interleukin-6; Joints; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protease Inhibitors; Rabbits; Random Allocation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Synovial Fluid; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha; Uric Acid

1996
Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain.
    Brain research, 1996, Feb-19, Volume: 709, Issue:2

    Topics: Animals; Ascorbic Acid; Azepines; Brain; Brain Ischemia; Bridged Bicyclo Compounds; Dehydroascorbic Acid; Extracellular Space; Fatty Acids, Monounsaturated; Free Radicals; Male; Oxygen; Partial Pressure; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion; Thromboxane A2; Triazoles

1996
Effect of locally applied WEB 2086, a platelet-activating factor antagonist, on inflammatory skin conditions in mice.
    Archives of dermatological research, 1996, Volume: 288, Issue:8

    Topics: Animals; Azepines; Dermatitis, Allergic Contact; Gels; Mice; Mice, Inbred Strains; Platelet Activating Factor; Radiodermatitis; Triazoles; Ultraviolet Rays

1996
Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils.
    British journal of pharmacology, 1996, Volume: 117, Issue:5

    Topics: Azepines; Cells, Cultured; Diterpenes; Dose-Response Relationship, Drug; Endothelium, Vascular; Ginkgolides; Humans; Lactones; Leukocyte Elastase; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Triazoles

1996
Pharmacological evidence of a role for platelet activating factor as a modulator of vasomotor tone and blood pressure.
    European journal of pharmacology, 1996, Jul-25, Volume: 308, Issue:3

    Topics: Animals; Azepines; Blood Pressure; Carotid Arteries; Diterpenes; Enzyme Inhibitors; Female; Ginkgolides; Glutamic Acid; Injections, Intraventricular; Lactones; Male; Muscle Tonus; Norepinephrine; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Membrane Glycoproteins; Quinacrine; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1996
Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells.
    Journal of neurochemistry, 1996, Volume: 67, Issue:4

    Topics: Animals; Azepines; Cell Line, Transformed; Cell Membrane; GTP-Binding Proteins; Guanosine Triphosphate; Hippocampus; Hybrid Cells; Immune Sera; Mice; Mice, Inbred C57BL; Neuroblastoma; Neurons; Pertussis Toxin; Phosphatidylinositols; Platelet Activating Factor; Triazoles; Virulence Factors, Bordetella

1996
Induction of IL-4 by platelet-activating factor.
    Clinical and experimental immunology, 1996, Volume: 106, Issue:1

    Topics: Antibodies, Monoclonal; Azepines; Cells, Cultured; Histocompatibility Antigens Class II; Humans; Immunoglobulin A; Interleukin-4; Interleukin-6; Leukocytes, Mononuclear; Lymphocyte Activation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1996
Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method.
    Journal of pharmacological and toxicological methods, 1996, Volume: 36, Issue:1

    Topics: Animals; Azepines; Binding, Competitive; Blood Platelets; Filtration; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1996
Effects of platelet activating factor on the distribution of radiolabelled leucocytes and platelets in normal horses and asymptomatic horses with chronic obstructive pulmonary disease.
    Research in veterinary science, 1996, Volume: 61, Issue:2

    Topics: Analysis of Variance; Animals; Azepines; Blood Platelets; Eosinophils; Heart Rate; Horse Diseases; Horses; Indium Radioisotopes; Leukocyte Count; Lung Diseases, Obstructive; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pleura; Pressure; Reference Values; Respiration; Respiratory Function Tests; Time Factors; Triazoles

1996
Escherichia coli hemolysin and Staphylococcus aureas alpha-toxin potently induce neutrophil adhesion to cultured human endothelial cells.
    Journal of immunology (Baltimore, Md. : 1950), 1996, Nov-01, Volume: 157, Issue:9

    Topics: Azepines; Bacterial Proteins; Bacterial Toxins; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Endothelium, Vascular; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation; Hemolysin Proteins; Humans; Macrophage-1 Antigen; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staphylococcus aureus; Thienopyridines; Triazoles; Umbilical Veins

1996
Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs.
    The European respiratory journal, 1996, Volume: 9, Issue:10

    Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Anesthesia, General; Animals; Antigens; Asthma; Azepines; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Hypersensitivity; Immunization; Inflammation Mediators; Injections, Intravenous; Male; Platelet Activating Factor; Propranolol; Respiration, Artificial; Time Factors; Triazoles

1996
Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1996, Volume: 43, Issue:7

    Topics: Animals; Azepines; Blood Platelets; Cattle; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Microscopy, Electron; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1996
Plasmin promotes an endothelium-dependent adhesion of neutrophils. Involvement of platelet activating factor and P-selectin.
    Circulation, 1996, Jun-15, Volume: 93, Issue:12

    Topics: Animals; Antibodies; Antibodies, Monoclonal; Azepines; Capillary Permeability; Cattle; CD18 Antigens; Cell Adhesion; Endothelium, Vascular; Fibrinolysin; Humans; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Streptokinase; Tissue Plasminogen Activator; Triazoles

1996
The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro
    Cytokine, 1996, Volume: 8, Issue:9

    Topics: Azepines; Cells, Cultured; Dose-Response Relationship, Drug; Epithelium; Humans; Interleukin-6; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Thymus Gland; Triazoles

1996
Demonstration of reversible priming of human neutrophils using platelet-activating factor.
    Blood, 1996, Dec-01, Volume: 88, Issue:11

    Topics: Adult; Azepines; Cell Adhesion; Cell Polarity; Cell Size; Cells, Cultured; Dihydropyridines; Enzyme Activation; Humans; Imidazoles; Macrophage-1 Antigen; Microspheres; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Burst; Superoxides; Time Factors; Triazoles; Tumor Necrosis Factor-alpha

1996
Effect of Y-24180, a platelet-activating factor-receptor antagonist, on the antigen-induced airway microvascular leakage in guinea pigs.
    Japanese journal of pharmacology, 1996, Volume: 72, Issue:3

    Topics: Animals; Antigens; Azepines; Bronchi; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Linear Models; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Trachea; Triazoles

1996
Effect of BN 50727 on pathological findings and tissue platelet activating factor levels during ileal ischemia in newborn piglets.
    Journal of pediatric surgery, 1996, Volume: 31, Issue:12

    Topics: Animals; Animals, Newborn; Azepines; Disease Models, Animal; Enterocolitis, Pseudomembranous; Humans; Ileum; Infant, Newborn; Ischemia; Platelet Activating Factor; Swine; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha

1996
Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney.
    Research communications in molecular pathology and pharmacology, 1996, Volume: 94, Issue:2

    Topics: Animals; Azepines; Dihydropyridines; Ginkgolides; In Vitro Techniques; Kidney; Lactones; Norepinephrine; Platelet Activating Factor; Rabbits; Tachyphylaxis; Triazoles; Vasoconstriction

1996
Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:1

    Topics: Administration, Oral; Animals; Azepines; Blood Pressure; Cyproheptadine; Dogs; Guinea Pigs; Histamine Antagonists; Male; Mice; Motor Activity; Platelet Activating Factor; Platelet Aggregation; Pyrilamine; Rabbits; Rats; Rats, Sprague-Dawley; Triazoles

1997
Augmented expression of platelet-activating factor receptor gene by TNF-alpha through transcriptional activation in human monocytes.
    Journal of leukocyte biology, 1997, Volume: 61, Issue:1

    Topics: Azepines; Half-Life; Humans; Interleukin-6; Monocytes; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Transcriptional Activation; Triazoles; Tumor Necrosis Factor-alpha; Up-Regulation

1997
Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages.
    Journal of immunology (Baltimore, Md. : 1950), 1997, Feb-01, Volume: 158, Issue:3

    Topics: Animals; Azepines; Cattle; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Collagen; Drug Combinations; Hepatocyte Growth Factor; Humans; Laminin; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Phosphotyrosine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles

1997
Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.
    FEBS letters, 1997, Feb-03, Volume: 402, Issue:2-3

    Topics: Amino Acid Sequence; Animals; Azepines; Binding, Competitive; CHO Cells; COS Cells; Cricetinae; Cysteine; Dithiothreitol; DNA Primers; Humans; Inositol Phosphates; Kinetics; Models, Structural; Mutagenesis, Site-Directed; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Protein Structure, Secondary; Proto-Oncogene Proteins c-myc; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Transfection; Triazoles

1997
Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs.
    Pharmacology, 1997, Volume: 54, Issue:1

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchodilator Agents; Chromones; Drug Interactions; Drug Therapy, Combination; Guinea Pigs; Heptanoic Acids; Male; Methacrylates; Platelet Activating Factor; Theophylline; Triazoles

1997
Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells.
    Advances in experimental medicine and biology, 1996, Volume: 416

    Topics: Alternative Splicing; Azepines; Calcium; Cells, Cultured; Endometrium; Estradiol; Female; Gene Expression; Humans; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Polymerase Chain Reaction; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Stromal Cells; Triazoles; Up-Regulation

1996
Role of platelet-activating factor in skeletal muscle ischemia-reperfusion injury.
    Advances in experimental medicine and biology, 1996, Volume: 416

    Topics: Animals; Azepines; Dogs; Female; Heart Rate; In Vitro Techniques; Ischemia; Muscle, Skeletal; Necrosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Reperfusion Injury; Triazoles

1996
Platelet-activating factor. A possible role in the modulation of the vasomotor tone and blood pressure.
    Advances in experimental medicine and biology, 1996, Volume: 416

    Topics: Adrenergic alpha-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Blood Pressure; Carotid Arteries; Diterpenes; Enzyme Inhibitors; Ginkgolides; Indomethacin; Lactones; Muscle Tonus; Muscle, Smooth, Vascular; Norepinephrine; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinacrine; Rabbits; Triazoles

1996
Non-specific PAF binding to embryonal F9 cells and prostacyclin synthesis in human umbilical vein endothelial cells.
    Advances in experimental medicine and biology, 1996, Volume: 416

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Carcinoma, Embryonal; Cell Line; Embryo, Mammalian; Endothelium, Vascular; Epoprostenol; Humans; Mice; Neoplasms, Germ Cell and Embryonal; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Umbilical Veins

1996
A mitogen-activated protein kinase (MAP-kinase) cascade is stimulated by platelet activating factor (PAF) in corneal epithelium.
    Current eye research, 1997, Volume: 16, Issue:4

    Topics: Animals; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, DEAE-Cellulose; Cornea; Enzyme Activation; Epithelium; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rabbits; Stimulation, Chemical; Thienopyridines; Triazoles

1997
The platelet-activating factor receptor antagonist WEB 2170 prevents neonatal necrotizing enterocolitis in rats.
    Journal of pediatric gastroenterology and nutrition, 1997, Volume: 24, Issue:3

    Topics: Animals; Animals, Newborn; Azepines; Enterocolitis, Pseudomembranous; Intestinal Mucosa; Intestine, Small; Necrosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1997
Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock.
    Surgery, 1997, Volume: 121, Issue:5

    Topics: Animals; Azepines; Blood Gas Analysis; Fluid Therapy; Hemodynamics; Lipopolysaccharides; Platelet Activating Factor; Platelet Aggregation Inhibitors; Resuscitation; Shock, Traumatic; Swine; Triazoles

1997
Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.
    The Journal of clinical investigation, 1997, May-15, Volume: 99, Issue:10

    Topics: Animals; Antioxidants; Ascorbic Acid; Azepines; Blood Platelets; Cell Adhesion; Cell Aggregation; Chemokine CCL4; Cricetinae; Humans; Interleukin-8; Macrophage Inflammatory Proteins; Monocytes; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reference Values; Smoking; Time Factors; Triazoles

1997
Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism.
    Arteriosclerosis, thrombosis, and vascular biology, 1997, Volume: 17, Issue:5

    Topics: Azepines; Humans; Immunity; Interferon-gamma; Leukocytes, Mononuclear; Lipoproteins, LDL; Oxidation-Reduction; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Necrosis Factor-alpha

1997
Species differences in PAF receptor binding in the lungs between hamster and guinea pig.
    Journal of lipid mediators and cell signalling, 1997, Volume: 16, Issue:2

    Topics: Animals; Azepines; Binding, Competitive; Cricetinae; Fibrinolytic Agents; Guinea Pigs; Kinetics; Ligands; Lung; Male; Mesocricetus; Organophosphorus Compounds; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Triazoles

1997
PAF antagonists as possible inhibitors of corneal epithelial defects and ulceration.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1997, Volume: 13, Issue:3

    Topics: Azepines; Cornea; Corneal Injuries; Diterpenes; Enzyme Activation; Epithelium; Extracellular Matrix Proteins; Fibrinolytic Agents; Ginkgolides; Lactones; Metalloendopeptidases; Phospholipid Ethers; Platelet Activating Factor; Thienopyridines; Triazoles; Urokinase-Type Plasminogen Activator; Wound Healing

1997
Platelet-activating factor stimulates interleukin-6 production by human endothelial cells and synergizes with tumor necrosis factor for enhanced production of granulocyte-macrophage colony stimulating factor.
    Inflammation, 1997, Volume: 21, Issue:2

    Topics: Azepines; Drug Synergism; Endothelium, Vascular; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1997
Studies of the nature of the binding by albumin of platelet-activating factor released from cells.
    The Journal of biological chemistry, 1997, Jul-25, Volume: 272, Issue:30

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Biological Availability; Blastocyst; Calcimycin; Cattle; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; Ionophores; Mice; Pepsin A; Peptide Mapping; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Binding; Protein Conformation; Serum Albumin; Serum Albumin, Bovine; Sulfhydryl Reagents; Triazoles; Trypsin

1997
Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration.
    Toxicology, 1997, Sep-05, Volume: 121, Issue:3

    Topics: Administration, Oral; Alanine Transaminase; Animals; Azepines; Blood Platelets; Chemical and Drug Induced Liver Injury; Female; Fibrinogen; Hydroxyurea; Injections, Intraperitoneal; Injections, Intravenous; Leukotrienes; Lipopolysaccharides; Lipoxygenase Inhibitors; Liver; Liver Diseases; Necrosis; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombocytopenia; Triazoles

1997
Dissociation of TNF-alpha from endotoxin-induced nitric oxide and acute-phase hypotension.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2

    Topics: Animals; Azepines; Blood Pressure; Endotoxins; Enzyme Induction; Escherichia coli; Heart Rate; Hypotension; Immunoglobulin G; Lipopolysaccharides; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thienopyridines; Time Factors; Transcription, Genetic; Triazoles; Tumor Necrosis Factor-alpha

1997
Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha.
    The American journal of pathology, 1997, Volume: 151, Issue:2

    Topics: Animals; Azepines; Cell Movement; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Activating Factor; Triazoles; Tumor Necrosis Factor-alpha

1997
Structural and functional requirements for agonist-induced internalization of the human platelet-activating factor receptor.
    The Journal of biological chemistry, 1997, Aug-22, Volume: 272, Issue:34

    Topics: Animals; Azepines; Cell Compartmentation; CHO Cells; COS Cells; Cricetinae; Endocytosis; GTP-Binding Proteins; Humans; Inositol Phosphates; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Transfection; Triazoles

1997
Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta.
    Veterinary immunology and immunopathology, 1997, Volume: 57, Issue:3-4

    Topics: Adjuvants, Immunologic; Animals; Azepines; Blood Coagulation Factors; Cattle; Endotoxins; Female; Fibrinolytic Agents; Humans; Indoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Leukotriene Antagonists; Lipoxygenase Inhibitors; Mammary Glands, Animal; Mastitis, Bovine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Recombinant Proteins; Sialoglycoproteins; Triazoles

1997
Human monocytes maintained in culture acquire functional responsiveness to platelet-activating factor that is independent of increases in protein tyrosine phosphorylation.
    Clinical and experimental pharmacology & physiology, 1997, Volume: 24, Issue:8

    Topics: Azepines; Calcium; Cells, Cultured; Humans; Monocytes; Oxygen; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Tyrosine

1997
Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: amelioration by platelet-activating factor antagonist BN 50739.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Animals; Azepines; Blood Pressure; Brain; Disease Models, Animal; Electroencephalography; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Femoral Artery; Hyperglycemia; Intracellular Membranes; Ischemic Attack, Transient; Lipid Peroxidation; Male; Membrane Lipids; Mitochondria; Oxygen Consumption; Phospholipids; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reference Values; Reperfusion; Thiobarbituric Acid Reactive Substances; Time Factors; Triazoles

1997
Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1997, Volume: 44, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Cattle; Dose-Response Relationship, Drug; Drug Synergism; Infusions, Intravenous; Ketoprofen; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Time Factors; Triazoles

1997
Effect of platelet-activating factor on bovine pulmonary function.
    The Veterinary record, 1997, Aug-16, Volume: 141, Issue:7

    Topics: Animals; Azepines; Cattle; Heart Rate; Lung; Lung Compliance; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Respiration; Respiratory Function Tests; Respiratory Mechanics; Tidal Volume; Triazoles

1997
Platelet-activating factor mediates angiotensin II-induced proteinuria in isolated perfused rat kidney.
    Journal of the American Society of Nephrology : JASN, 1997, Volume: 8, Issue:9

    Topics: Angiotensin II; Animals; Azepines; Dexamethasone; Glucocorticoids; In Vitro Techniques; Kidney; Male; Perfusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Proteinuria; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1997
cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2

    Topics: Animals; Azepines; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Female; Glomerular Mesangium; Indomethacin; Kinetics; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Transcription, Genetic; Triazoles; Virulence Factors, Bordetella

1997
A simple, rapid and specific radioreceptor assay for platelet-activating factor.
    Advances in experimental medicine and biology, 1997, Volume: 407

    Topics: Animals; Azepines; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Humans; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Substrate Specificity; Triazoles

1997
The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves.
    Veterinary research communications, 1997, Volume: 21, Issue:7

    Topics: Animals; Azepines; Cattle; Chromatography, High Pressure Liquid; Infusions, Intravenous; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Time Factors; Triazoles

1997
Eosinophil chemotaxis induced by several biologically active substances and the effects of apafant on it in vitro.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:10

    Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Chemotaxis; Eosinophils; Guinea Pigs; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles

1997
Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes.
    American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:5

    Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Chromones; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Lung; Methacrylates; Mice; Mice, Transgenic; Phenylpropionates; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Thromboxanes; Triazoles

1997
Platelet-activating factor induces cyclooxygenase-2 gene expression in corneal epithelium. Requirement of calcium in the signal transduction pathway.
    Investigative ophthalmology & visual science, 1997, Volume: 38, Issue:12

    Topics: Aniline Compounds; Animals; Azepines; Blotting, Northern; Blotting, Western; Calcimycin; Calcium; Cyclooxygenase 2; Enzyme Induction; Epithelium, Corneal; Fluorescent Dyes; Gene Expression; Ionophores; Isoenzymes; Microscopy, Confocal; Organ Culture Techniques; Peroxidases; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rabbits; RNA, Messenger; Signal Transduction; Thienopyridines; Triazoles; Xanthenes

1997
Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action.
    Pharmacology, 1997, Volume: 54, Issue:5

    Topics: Acetylcholine; Administration, Oral; Animals; Azepines; Binding Sites; Blood Platelets; Bradykinin; Bronchial Hyperreactivity; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Injections, Intravenous; Leukotriene D4; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Structure-Activity Relationship; Triazoles

1997
[A study on changes and its mechanisms of intestinal mucosal permeability after severe burn].
    Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns, 1996, Volume: 12, Issue:5

    Topics: Animals; Azepines; Burns; Female; Intestinal Mucosa; Male; Permeability; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Technetium Tc 99m Pentetate; Triazoles

1996
Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea.
    Respirology (Carlton, Vic.), 1997, Volume: 2, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkylating Agents; Animals; Azepines; Bronchitis; Capillary Permeability; Coloring Agents; Disease Models, Animal; Drug Interactions; Evans Blue; Indazoles; Leukotrienes; Male; Mechlorethamine; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rabbits; Reference Values; Trachea; Triazoles; Vasoconstrictor Agents

1997
Lung oedema induced by Tityus serrulatus scorpion venom in the rat.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1997, Volume: 118, Issue:2

    Topics: Animals; Aprotinin; Azepines; Capillary Permeability; Cyclooxygenase Inhibitors; Diterpenes; Drug Interactions; Fibrinolytic Agents; Ginkgolides; Hemostatics; Heparin; Hypertension; Injections, Intravenous; Lactones; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandins; Pulmonary Edema; Rats; Rats, Wistar; Scorpion Venoms; Triazoles

1997
Effects of apafant on PAF-induced downregulation of beta-adrenoceptors in guinea pigs.
    Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:8

    Topics: Adrenergic beta-Agonists; Animals; Azepines; Binding, Competitive; Bronchi; Down-Regulation; Guinea Pigs; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Platelet Activating Factor; Platelet Aggregation Inhibitors; Receptors, Adrenergic, beta; Triazoles

1997
Inhibitor effect of apafant on bronchopulmonary responses to platelet activating factor and to antigen in rats.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:12

    Topics: Animals; Azepines; Bronchi; Histamine; Hypersensitivity, Immediate; In Vitro Techniques; Lung; Male; Organ Size; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pulmonary Circulation; Rats; Rats, Inbred BN; Rats, Wistar; Triazoles

1997
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Neutrophils; P-Selectin; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles

1998
Possible mechanism of alprazolam-induced amnesia in mice.
    Pharmacology, 1998, Volume: 56, Issue:1

    Topics: Alprazolam; Amnesia; Animals; Azepines; Drug Evaluation, Preclinical; Female; Flumazenil; GABA Agonists; Male; Maze Learning; Mice; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles

1998
Platelet-activating factor mediates monocyte chemoattractant protein-1 expression in glomerular immune injury.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1998, Volume: 13, Issue:1

    Topics: Animals; Azepines; Chemokine CCL2; Complement System Proteins; Glomerulonephritis; Kidney Glomerulus; Male; Platelet Activating Factor; Polymerase Chain Reaction; Rabbits; Rats; Rats, Wistar; RNA, Messenger; Triazoles

1998
Investigation of the effects of platelet-activating factor (PAF) on ion transport and prostaglandin synthesis in human colonic mucosa in vitro.
    British journal of pharmacology, 1998, Volume: 123, Issue:2

    Topics: Azepines; Biological Transport; Colon; Humans; Intestinal Mucosa; Ions; Membrane Potentials; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prostaglandins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1998
Involvement of platelet-activating factor in cell death induced under ischemia/postischemia-like conditions in an immortalized hippocampal cell line.
    Journal of neurochemistry, 1998, Volume: 70, Issue:3

    Topics: Azepines; Calcium; Cell Death; Cell Line, Transformed; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Ischemia; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reperfusion Injury; Signal Transduction; Triazoles

1998
PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition.
    Pulmonary pharmacology & therapeutics, 1997, Volume: 10, Issue:3

    Topics: Albumins; Animals; Anti-Asthmatic Agents; Azepines; Bradykinin; Drug Interactions; Female; Ferrets; Male; Muramidase; Nedocromil; Platelet Activating Factor; Platelet Aggregation Inhibitors; Trachea; Triazoles

1997
The acute increases in vasomotor tone and blood pressure induced by carotid artery occlusion are modulated by platelet-activating factor (PAF) independently of nitric oxide release.
    Journal of lipid mediators and cell signalling, 1997, Volume: 17, Issue:3

    Topics: Animals; Azepines; Blood Pressure; Cardiac Output; Carotid Arteries; Carotid Stenosis; Enzyme Inhibitors; Feedback; Female; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pressoreceptors; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles; Vascular Resistance; Vasoconstriction

1997
Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla.
    The Annals of otology, rhinology, and laryngology, 1998, Volume: 107, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Azepines; Biphenyl Compounds; Chinchilla; Dinoprostone; Ear, Middle; Fatty Acids, Nonesterified; Heptanoic Acids; Hydrolases; Leukotriene Antagonists; Leukotriene C4; Mucous Membrane; Otitis Media; Phospholipids; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pneumococcal Infections; Propionates; Quinolines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Thromboxane; Thromboxane B2; Triazoles

1998
High and low affinity mutants of platelet-activating factor receptor.
    Advances in experimental medicine and biology, 1997, Volume: 433

    Topics: Amino Acid Sequence; Animals; Azepines; COS Cells; Guinea Pigs; Kinetics; Mutagenesis, Site-Directed; Oligopeptides; Peptides; Platelet Activating Factor; Platelet Membrane Glycoproteins; Point Mutation; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Transfection; Triazoles; Tritium

1997
Effects of platelet-activating factor on intracellular Ca2+ concentration and contractility in isolated cardiomyocytes.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:5

    Topics: Analysis of Variance; Animals; Azepines; Calcium; Male; Myocardial Contraction; Myocardium; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles

1998
Inhibition of tumor necrosis factor-alpha production by SK&F 98625, a CoA-independent transacylase inhibitor, in cultured rat peritoneal macrophages.
    Life sciences, 1998, Volume: 62, Issue:20

    Topics: Acyltransferases; Animals; Azepines; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Furans; Imidazoles; Macrophages, Peritoneal; Male; Organophosphorus Compounds; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Thapsigargin; Triazoles; Tumor Necrosis Factor-alpha

1998
Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.
    The Journal of biological chemistry, 1998, Jun-05, Volume: 273, Issue:23

    Topics: Androstadienes; Animals; Azepines; Cell Adhesion Molecules; Cell Movement; Chromones; Colonic Neoplasms; Dogs; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Genes, src; GTP-Binding Proteins; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Kidney; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Thiazoles; Transformation, Genetic; Triazoles; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin

1998
The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs.
    Current eye research, 1998, Volume: 17, Issue:5

    Topics: Animals; Anterior Chamber; Aqueous Humor; Azepines; Betamethasone; Chemotaxis, Leukocyte; Dinoprostone; Escherichia coli; Flow Cytometry; Guinea Pigs; Indomethacin; Leukocyte Count; Leukocytes; Lipopolysaccharides; Male; Ophthalmic Solutions; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Uveitis, Anterior

1998
In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes.
    The Journal of investigative dermatology, 1998, Volume: 110, Issue:6

    Topics: Animals; Azepines; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gene Expression; Genes; Humans; In Situ Hybridization; Keratinocytes; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Skin; Transcription, Genetic; Triazoles

1998
Inhibition of Na+,K(+)-ATPase by platelet-activating factor in dog submandibular glands.
    Prostaglandins & other lipid mediators, 1998, Volume: 55, Issue:5-6

    Topics: Animals; Azepines; Binding Sites; Dogs; Membrane Proteins; Mucins; Ouabain; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sodium-Potassium-Exchanging ATPase; Subcellular Fractions; Submandibular Gland; Triazoles

1998
Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves.
    Veterinary research communications, 1998, Volume: 22, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Blood Platelets; Cattle; Golgi Apparatus; Ketoprofen; Male; Microscopy, Electron; Microtubules; Mitochondria; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Count; Reference Values; Triazoles

1998
Platelet-activating factor is a downstream messenger of kainate-induced activation of mitogen-activated protein kinases in primary hippocampal neurons.
    Journal of neuroscience research, 1998, Aug-01, Volume: 53, Issue:3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astrocytes; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuronal Plasticity; Neurons; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Kinases; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles

1998
Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro.
    The European respiratory journal, 1998, Volume: 12, Issue:1

    Topics: Airway Resistance; Animals; Azepines; Bronchial Hyperreactivity; Culture Techniques; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Muscle, Smooth; Platelet Activating Factor; Platelet Aggregation Inhibitors; Recombinant Proteins; Triazoles; Tumor Necrosis Factor-alpha

1998
PAF and CD18 mediate neutrophil infiltration in upper gastrointestinal tract during intra-abdominal sepsis.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: Abdomen; Animals; Antibodies, Monoclonal; Azepines; Blood Pressure; CD18 Antigens; Cecum; Hematocrit; Intercellular Adhesion Molecule-1; Intestines; Leukocyte Count; Male; Neutrophils; Peroxidase; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Sepsis; Triazoles

1998
Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke.
    The European respiratory journal, 1998, Volume: 12, Issue:2

    Topics: Animals; Azepines; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Guinea Pigs; Male; Nicotiana; Plants, Toxic; Platelet Activating Factor; Pulmonary Eosinophilia; Smoke; Time Factors; Triazoles

1998
Platelet-activating factor modulates pulmonary vasomotor tone in the perinatal lamb.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:3

    Topics: Angiotensin II; Animals; Animals, Newborn; Azepines; Blood Pressure; Female; Muscle Tonus; Muscle, Smooth, Vascular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pregnancy; Pulmonary Circulation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sheep; Triazoles; Vascular Resistance; Vasoconstrictor Agents

1998
Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Sep-15, Volume: 161, Issue:6

    Topics: Adjuvants, Immunologic; Azepines; Cell Culture Techniques; Cell Line; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Drug Synergism; Eosinophils; Epithelial Cells; Humans; Immunization; Leukocyte Count; Lung; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Cells, Cultured

1998
Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats.
    Pharmacological research, 1998, Volume: 38, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Azepines; Hemodynamics; Ischemic Preconditioning; Male; Platelet Activating Factor; Rats; Triazoles

1998
Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice.
    The Journal of experimental medicine, 1998, Nov-02, Volume: 188, Issue:9

    Topics: Anaphylaxis; Animals; Antibodies, Monoclonal; Azepines; Female; Haptens; Histamine; Immunoglobulin E; Interleukin-4; Mast Cells; Mice; Mice, Mutant Strains; Penicillin V; Platelet Activating Factor; Triazoles

1998
Modulation by lipid mediators of immune complex-induced lung inflammation in mice.
    European journal of pharmacology, 1998, Nov-13, Volume: 361, Issue:1

    Topics: Animals; Antigen-Antibody Complex; Arthus Reaction; Azepines; Benzopyrans; Blood Vessels; Bronchoalveolar Lavage Fluid; Capillary Permeability; Dose-Response Relationship, Drug; Eicosanoids; Hemoglobins; Immune Complex Diseases; Indoles; Indomethacin; Lipoxygenase Inhibitors; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neutrophils; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pneumonia; Receptors, Leukotriene B4; Species Specificity; Triazoles

1998
Xenogeneic rejection mechanisms shown by intravital microscopy.
    Transplantation proceedings, 1998, Volume: 30, Issue:8

    Topics: Animals; Azepines; Bile; Blood Pressure; Blood Transfusion; Elapid Venoms; Graft Rejection; Humans; Liver Circulation; Microcirculation; Microscopy, Fluorescence; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous; Transplantation, Isogeneic; Triazoles

1998
Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47, Issue:12

    Topics: Animals; Azepines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Ear; Eosinophils; Female; Immunoglobulin E; Kinetics; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1998
Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change.
    The American journal of pathology, 1999, Volume: 154, Issue:2

    Topics: Angiotensin II; Azepines; Cell Size; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Glomerular Mesangium; Humans; Interleukin-12; Interleukin-8; Lipopolysaccharides; Platelet Activating Factor; Platelet Aggregation Inhibitors; Receptors, Interleukin; Receptors, Interleukin-12; RNA, Messenger; Superoxides; Time Factors; Triazoles; Tumor Necrosis Factor-alpha

1999
Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death.
    The Journal of biological chemistry, 1999, Mar-05, Volume: 274, Issue:10

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Hippocampus; Neurons; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Second Messenger Systems; Signal Transduction; Thienopyridines; Triazoles

1999
Intracellular mechanisms of hydrogen peroxide-mediated neutrophil adherence to cultured human endothelial cells.
    Microvascular research, 1999, Volume: 57, Issue:2

    Topics: Azepines; Calcimycin; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hydrogen Peroxide; In Vitro Techniques; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase Inhibitors; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Second Messenger Systems; Tetradecanoylphorbol Acetate; Triazoles

1999
Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application.
    Stroke, 1999, Volume: 30, Issue:4

    Topics: Animals; Azepines; Blood Pressure; Blood-Brain Barrier; Carbon Dioxide; Cell Communication; Cerebrovascular Circulation; Endothelium, Vascular; Hematocrit; Hydrogen-Ion Concentration; Leukocyte Count; Leukocytes; Male; Microcirculation; Microscopy, Fluorescence; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles

1999
Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application.
    Stroke, 1999, Volume: 30, Issue:4

    Topics: Animals; Azepines; Blood Pressure; Blood-Brain Barrier; Cell Communication; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; Leukocytes; Male; Microcirculation; Microscopy, Fluorescence; Pia Mater; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles

1999
Effects of Y-24180, a receptor antagonist to platelet-activating factor, on allergic cutaneous eosinophilia in mice.
    Life sciences, 1999, Volume: 64, Issue:11

    Topics: Animals; Azepines; Cytokines; Eosinophilia; Hypersensitivity; Male; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Skin Diseases; Triazoles

1999
Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism.
    Circulation research, 1999, Apr-16, Volume: 84, Issue:7

    Topics: Animals; Azepines; Biocompatible Materials; Biological Transport; Cell Division; Cell Movement; Cell Nucleus; Cells, Cultured; Collagen; DNA-Binding Proteins; Drug Combinations; Endothelium, Vascular; Fibroblast Growth Factor 2; Gene Expression; Humans; Interleukin-8; Kinetics; Laminin; Mice; Milk Proteins; Neoplasm Proteins; Neovascularization, Physiologic; Phosphorylation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Proteoglycans; Proto-Oncogene Proteins; Receptors, Cytokine; Receptors, Thrombopoietin; Signal Transduction; STAT1 Transcription Factor; STAT5 Transcription Factor; Thrombopoietin; Trans-Activators; Triazoles; Tyrosine; Umbilical Veins

1999
Effect of platelet activating factor and its antagonist on the mucociliary clearance of the eustachian tube in guinea pigs.
    The Annals of otology, rhinology, and laryngology, 1999, Volume: 108, Issue:5

    Topics: Animals; Azepines; Cilia; Coloring Agents; Dose-Response Relationship, Drug; Epithelium; Eustachian Tube; Guinea Pigs; Microscopy, Electron; Mucociliary Clearance; Otitis Media with Effusion; Platelet Activating Factor; Rosaniline Dyes; Triazoles

1999
The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat.
    European journal of immunology, 1999, Volume: 29, Issue:5

    Topics: Azepines; Chemotaxis; Gene Products, tat; HIV-1; Humans; Monocytes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; tat Gene Products, Human Immunodeficiency Virus; Triazoles

1999
Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1999, Volume: 18, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Azepines; Captopril; Coronary Disease; Disease Models, Animal; Drug Therapy, Combination; Heart Transplantation; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Inbred F344; Rats, Inbred Lew; Transplantation, Homologous; Treatment Outcome; Triazoles; Ventricular Remodeling

1999
Mechanisms of interaction of a plasmalogenic analog of platelet-activating factor with human platelets.
    Biochemistry. Biokhimiia, 1999, Volume: 64, Issue:6

    Topics: Adenylyl Cyclase Inhibitors; Alprostadil; Azepines; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Humans; Kinetics; Plasmalogens; Platelet Activating Factor; Triazoles

1999
Possible participation of intracellular platelet-activating factor in tumor necrosis factor-alpha production by rat peritoneal macrophages.
    European journal of pharmacology, 1999, Jun-25, Volume: 374, Issue:3

    Topics: Animals; Azepines; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Furans; Imidazoles; Indomethacin; Macrophages, Peritoneal; Male; Organophosphorus Compounds; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thapsigargin; Triazoles; Tumor Necrosis Factor-alpha

1999
Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1999, Volume: 50, Issue:2

    Topics: Animals; Azepines; Blood Pressure; Enzyme Inhibitors; Escherichia coli; Indans; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thromboxane A2; Triazoles

1999
Proposal of a new PAF pharmacophoric map by the AM1 method.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1999, Volume: 8, Issue:4

    Topics: Azepines; Models, Molecular; Molecular Conformation; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Quantum Theory; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Triazoles

1999
HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity.
    Journal of neurochemistry, 1999, Volume: 73, Issue:2

    Topics: Animals; Antimanic Agents; Azepines; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Enzyme Activation; Excitatory Amino Acid Agonists; Gene Products, tat; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; HIV-1; Lithium Chloride; N-Methylaspartate; Neurons; Neurotoxins; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; tat Gene Products, Human Immunodeficiency Virus; Triazoles

1999
Involvement of platelet-activating factor in the modulation of vascular tone in the isolated perfused rabbit kidney.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 359, Issue:6

    Topics: Animals; Azepines; Dinoprost; Enzyme Inhibitors; Female; Furans; In Vitro Techniques; Kidney; Lignans; Male; Muscle Tonus; Muscle, Smooth, Vascular; Norepinephrine; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinacrine; Rabbits; Renal Circulation; Triazoles; Vasoconstrictor Agents

1999
Role of nitric oxide and platelet-activating factor in cardiac alterations induced by tumor necrosis factor-alpha in the guinea-pig papillary muscle.
    Cardiovascular research, 1999, Volume: 41, Issue:3

    Topics: Action Potentials; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Azepines; Cyclooxygenase Inhibitors; Depression, Chemical; Guinea Pigs; Heart; In Vitro Techniques; Indomethacin; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Propranolol; Triazoles; Tumor Necrosis Factor-alpha

1999
Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Aug-15, Volume: 163, Issue:4

    Topics: Animals; Apolipoproteins; Apolipoproteins D; Azepines; Carrier Proteins; Cell Division; Cell Line; Cell Movement; DNA-Binding Proteins; Endothelium, Vascular; Female; Glycoproteins; Humans; Injections, Subcutaneous; Interleukin-3; Macromolecular Substances; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Milk Proteins; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Binding; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Interleukin-3; STAT5 Transcription Factor; Trans-Activators; Triazoles; Tumor Suppressor Proteins

1999
Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086.
    Circulation research, 1999, Aug-20, Volume: 85, Issue:4

    Topics: Animals; Arteriosclerosis; Azepines; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Lipid Peroxidation; Mice; Monocytes; Phospholipid Ethers; Phospholipids; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles

1999
Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism.
    Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Azepines; Disease Models, Animal; Male; Myocardial Ischemia; Perfusion; Platelet Activating Factor; Protective Agents; Rats; Rats, Wistar; Triazoles; Vasodilation; Ventricular Fibrillation

1999
Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia.
    Prostaglandins & other lipid mediators, 1999, Volume: 58, Issue:1

    Topics: Animals; Azepines; Dactinomycin; Gene Expression Regulation; Kinetics; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Histamine H1; Triazoles; Trigeminal Ganglion

1999
Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor.
    Pharmacology & toxicology, 1999, Volume: 85, Issue:3

    Topics: Animals; Azepines; Bucladesine; Cholera Toxin; Glomerular Filtration Rate; In Vitro Techniques; Kidney Glomerulus; Male; Perfusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Sodium; Triazoles; Urodynamics

1999
Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression.
    Journal of neuroscience research, 1999, Nov-15, Volume: 58, Issue:4

    Topics: Animals; Azepines; Cyclooxygenase 2; Enzyme Induction; Hippocampus; Interleukin-1; Isoenzymes; Mice; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Recombinant Proteins; Thienopyridines; Triazoles

1999
Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells.
    Hepatology (Baltimore, Md.), 1999, Volume: 30, Issue:5

    Topics: Alanine Transaminase; Animals; Azepines; Cell Nucleus; Cells, Cultured; Cytoplasm; DNA-Binding Proteins; Endotoxemia; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Kupffer Cells; Lipopolysaccharides; Liver; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic; Triazoles

1999
Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis.
    The American journal of pathology, 1999, Volume: 155, Issue:5

    Topics: Azepines; Cell Movement; Diterpenes; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gene Products, tat; Ginkgolides; HIV-1; Humans; Lactones; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sarcoma, Kaposi; tat Gene Products, Human Immunodeficiency Virus; Triazoles; Tumor Cells, Cultured

1999
Mechanosensitive properties of gastric vagal afferent fibers in the rat.
    Journal of neurophysiology, 1999, Volume: 82, Issue:5

    Topics: Afferent Pathways; Animals; Azepines; Dilatation; Infusions, Intra-Arterial; Male; Mechanoreceptors; Muscle, Smooth; Nerve Fibers; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Stomach; Triazoles; Vagus Nerve

1999
Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1999, Volume: 50, Issue:3

    Topics: Animals; Azepines; Cell Movement; Endotoxemia; Indans; Lactic Acid; Lipopolysaccharides; Lung; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thromboxane A2; Triazoles

1999
Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock.
    Critical care medicine, 1999, Volume: 27, Issue:11

    Topics: Aeromonas hydrophila; Animals; Arachidonic Acid; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Eicosanoids; Female; Gram-Negative Bacterial Infections; Heart Diseases; Hemodynamics; Hypertension, Pulmonary; Lipoxygenase Inhibitors; Masoprocol; Oxazoles; Oxygen; Oxygen Consumption; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Shock, Septic; Swine; Thromboxane A2; Triazoles; Tumor Necrosis Factor-alpha

1999
Inhibition of eosinophil activation in bronchoalveolar lavage fluid from atopic asthmatics by Y-24180, an antagonist to platelet-activating factor.
    Life sciences, 1999, Volume: 65, Issue:20

    Topics: Adult; Antigens, CD; Asthma; Azepines; Blood Proteins; Bronchi; Bronchoalveolar Lavage Fluid; Eosinophil Granule Proteins; Eosinophils; Female; Fibronectins; Humans; Integrin alpha1; Intercellular Adhesion Molecule-1; Leukocyte Count; Macrophage-1 Antigen; Male; Middle Aged; Platelet Activating Factor; Ribonucleases; Triazoles

1999
Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi.
    Biochemical and biophysical research communications, 1999, Dec-09, Volume: 266, Issue:1

    Topics: Animals; Azepines; Culture Media, Conditioned; Phosphoprotein Phosphatases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Triazoles; Trypanosoma cruzi

1999
Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:1

    Topics: Animals; Azepines; Cell Movement; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Lymphokines; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Skin; Triazoles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell- and platelet-activating factor receptor-dependent pathway in rats.
    Scandinavian journal of gastroenterology, 1999, Volume: 34, Issue:12

    Topics: Animals; Azepines; Blood Pressure; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; In Vitro Techniques; Ketotifen; Laser-Doppler Flowmetry; Male; Mast Cells; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Platelet Activating Factor; Rats; Rats, Inbred Lew; Triazoles

1999
Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:1

    Topics: Animals; Azepines; Cell Death; Cell Line; Coculture Techniques; Dose-Response Relationship, Drug; Endothelium, Vascular; Macrophages, Peritoneal; Mice; Phagocytes; Phagocytosis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridinium Compounds; Triazoles; Tumor Necrosis Factor-alpha

2000
Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor.
    British journal of pharmacology, 2000, Volume: 129, Issue:2

    Topics: Animals; Antibodies, Blocking; Azepines; Cell Nucleus; Electrophoresis; Epithelial Cells; Ileum; Immunohistochemistry; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Neutrophils; NF-kappa B; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Triazoles; Tumor Necrosis Factor-alpha

2000
Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves.
    American journal of veterinary research, 2000, Volume: 61, Issue:3

    Topics: Animals; Azepines; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cattle; Flow Cytometry; Hemoglobins; Intradermal Tests; Leukocyte Count; Lung; Macrophage-1 Antigen; Male; Mannheimia haemolytica; Neutrophils; Pasteurellosis, Pneumonic; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pulmonary Alveoli; Triazoles

2000
Interferon-gamma-induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis.
    Blood, 2000, Apr-01, Volume: 95, Issue:7

    Topics: Adult; Azepines; Calcium; Cell Membrane; Cytotoxicity, Immunologic; Gene Expression; Humans; Interferon-gamma; Killer Cells, Natural; Membrane Glycoproteins; Neoplasms; Perforin; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pore Forming Cytotoxic Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Transfection; Triazoles; Tumor Cells, Cultured

2000
Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin.
    British journal of pharmacology, 2000, Volume: 129, Issue:7

    Topics: Animals; Azepines; Cadherins; Cytoskeleton; Dextrans; Enzyme Inhibitors; Epithelium; Glucose; Hypotension; Intestinal Mucosa; Intestines; Leukocytosis; Male; Permeability; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Protein-Tyrosine Kinases; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Triazoles; Tyrosine; Tyrphostins

2000
The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats.
    The Journal of biological chemistry, 2000, Jun-30, Volume: 275, Issue:26

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; DNA, Complementary; Endotoxemia; Endotoxins; Kupffer Cells; Leukocytes; Lipopolysaccharides; Liver; Macrophages, Peritoneal; Male; Phospholipases A; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Chloride; Tissue Distribution; Triazoles; Up-Regulation

2000
Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:4

    Topics: Animals; Animals, Newborn; Azepines; Binding, Competitive; Cell Membrane; DNA, Complementary; Female; Gene Expression Regulation, Developmental; Lung; Molecular Sequence Data; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pregnancy; Pulmonary Circulation; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Nucleic Acid; Sheep; Triazoles; Tritium

2000
Effects of the platelet activating factor antagonists BN 52021 and BN 50730 on antigen-induced bronchial hyperresponsiveness and eosinophil infiltration in lung from sensitized guinea-pigs.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1993, Volume: 23, Issue:12

    Topics: Acetylcholine; Aerosols; Animals; Azepines; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Diterpenes; Eosinophilia; Ginkgo biloba; Ginkgolides; Guinea Pigs; Lactones; Leukotriene B4; Lung Diseases; Male; Molecular Structure; Ovalbumin; Plants, Medicinal; Platelet Activating Factor; Specific Pathogen-Free Organisms; Thienopyridines; Triazoles

1993
Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line.
    Molecular medicine (Cambridge, Mass.), 2000, Volume: 6, Issue:1

    Topics: Azepines; Calcium; Cell Line; Endometrium; Enzyme Activation; Epithelial Cells; Female; Humans; Indoles; Infertility, Female; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase C-alpha; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles

2000
Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection.
    Pediatric research, 2000, Volume: 48, Issue:1

    Topics: Animals; Animals, Newborn; Atrophy; Azepines; Brain; Brain Edema; Female; Hypoxia-Ischemia, Brain; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles; Weight Gain

2000
Y-24180, an antagonist of platelet-activating factor, suppresses interleukin 5 production in cultured murine th(2)cells and human peripheral blood mononuclear cells.
    Cytokine, 2000, Volume: 12, Issue:7

    Topics: Animals; Azepines; Cells, Cultured; Gene Expression; Humans; Interleukin-5; Leukocytes, Mononuclear; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Th2 Cells; Triazoles

2000
Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 279, Issue:1

    Topics: Animals; Azepines; Cell Adhesion; Indicators and Reagents; Interleukin-1; Intubation, Intratracheal; Leukocyte Count; Lung; Lung Diseases; Male; Neutrophils; Nitroblue Tetrazolium; Permeability; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Proteins; Time Factors; Triazoles

2000
Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC).
    Neurochemical research, 2000, Volume: 25, Issue:5

    Topics: Animals; Astrocytes; Azepines; Cell Line, Transformed; Cytokines; Diterpenes; Enzyme Induction; Gene Expression Regulation, Enzymologic; Ginkgolides; Group II Phospholipases A2; Interferon-gamma; Interleukin-1; Lactones; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha

2000
Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB.
    Inflammation, 2000, Volume: 24, Issue:5

    Topics: Acetylcysteine; Animals; Antioxidants; Azepines; Benzoquinones; Disseminated Intravascular Coagulation; DNA-Binding Proteins; Female; Gene Expression Regulation; Genistein; Hemorrhage; Hydrogen Peroxide; I-kappa B Proteins; Isoflavones; Kidney Medulla; Lactams, Macrocyclic; Lethal Dose 50; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Platelet Activating Factor; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pulmonary Edema; Pyrrolidines; Quinones; Reactive Oxygen Species; Rifabutin; Serine Proteinase Inhibitors; Signal Transduction; Specific Pathogen-Free Organisms; Succinic Acid; Thiocarbamates; Tosylphenylalanyl Chloromethyl Ketone; Triazoles; Tumor Necrosis Factor-alpha; Vitamin E

2000
Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Azepines; Cell Movement; Endothelin-1; Female; Injections, Intra-Arterial; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Intestine, Small; Luminescent Measurements; Male; Necrosis; Neutrophils; Oxidative Stress; Peroxidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Triazoles

2000
Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 11, Issue:4

    Topics: Animals; Azepines; Models, Molecular; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Triazoles

2000
Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils.
    Prostaglandins & other lipid mediators, 2000, Volume: 62, Issue:4

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Azepines; Calcium; Cytosol; Enzyme Inhibitors; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rabbits; Terpenes; Tosylphenylalanyl Chloromethyl Ketone; Triazoles

2000
PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis.
    The American journal of pathology, 2000, Volume: 157, Issue:5

    Topics: Animals; Azepines; Breast Neoplasms; Cell Division; Cell Movement; Female; Humans; Mice; Mice, SCID; Neoplasm Transplantation; Neovascularization, Pathologic; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Cells, Cultured

2000
Role of NO and PAF in the impairment of skeletal muscle contractility induced by TNF-alpha.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:6

    Topics: Animals; Azepines; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Phospholipases A; Platelet Activating Factor; S-Nitroso-N-Acetylpenicillamine; Stereoisomerism; Triazoles; Tumor Necrosis Factor-alpha

2000
PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:3

    Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Cell Count; Eosinophils; Goblet Cells; Guinea Pigs; Male; Metaplasia; Nicotiana; Peroxidase; Plants, Toxic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Skin; Smoke; Trachea; Triazoles

2001
Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat.
    European journal of immunology, 2001, Volume: 31, Issue:2

    Topics: Angiogenesis Inducing Agents; Animals; Azepines; Cell Movement; Endothelium, Vascular; Female; Gene Products, tat; HIV-1; Humans; Mice; Mice, Inbred C57BL; Platelet Activating Factor; tat Gene Products, Human Immunodeficiency Virus; Triazoles

2001
The role of platelet-activating factor (PAF) antagonists and nitric oxide in cardiac actions of PAF. Electrophysiological and morphological study.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2000, Volume: 51, Issue:4 Pt 1

    Topics: 4-Aminopyridine; Action Potentials; Animals; Azepines; Diterpenes; Electrophysiology; Fibrinolytic Agents; Ginkgolides; Glyburide; Guinea Pigs; Heart; In Vitro Techniques; Lactones; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Potassium Channel Blockers; Reperfusion Injury; Triazoles

2000
Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity.
    Life sciences, 2001, Jan-26, Volume: 68, Issue:10

    Topics: Animals; Azepines; Cyclosporine; Dose-Response Relationship, Drug; Endothelin-1; Hemodynamics; Immunosuppressive Agents; Kidney; Male; Platelet Activating Factor; Rats; Rats, Wistar; Thromboxane B2; Triazoles

2001
Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression.
    American journal of respiratory cell and molecular biology, 2001, Volume: 24, Issue:4

    Topics: Aged; Antibodies; Antioxidants; Azepines; Bacterial Adhesion; Cells, Cultured; Epithelial Cells; Female; Gene Expression; Humans; Hydrochloric Acid; Interleukin-1; Male; Middle Aged; Neutralization Tests; NF-kappa B; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pneumococcal Infections; Pneumonia, Aspiration; Pyrrolidines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Streptococcus pneumoniae; Thiocarbamates; Trachea; Triazoles

2001
[Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2000, Volume: 23, Issue:10

    Topics: Animals; Azepines; Female; Leukocyte Elastase; Lung; Male; Pancreatitis, Acute Necrotizing; Peroxidase; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Random Allocation; Respiratory Mucosa; Swine; Trachea; Triazoles

2000
Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis.
    Current microbiology, 2001, Volume: 43, Issue:1

    Topics: Animals; Azepines; Female; Leishmania; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Triazoles

2001
Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats.
    Pediatric research, 2001, Volume: 49, Issue:6

    Topics: Animals; Animals, Newborn; Azepines; Brain Injuries; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Hippocampus; Hypoxia, Brain; Learning; Memory; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Thienopyridines; Triazoles

2001
Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.
    Circulation, 2001, Jul-31, Volume: 104, Issue:5

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; GTP-Binding Proteins; Indoles; Isoquinolines; Lipoproteins, LDL; Pertussis Toxin; Phospholipases A; Platelet Activating Factor; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Signal Transduction; Sulfonamides; Triazoles; Virulence Factors, Bordetella

2001
[The role and significance of PAF in the early pulmonary injury following burns combined with endotoxemia in rats].
    Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns, 1999, Volume: 15, Issue:6

    Topics: Animals; Azepines; Burns; Endotoxemia; Female; Lung; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Random Allocation; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles; Tumor Necrosis Factor-alpha

1999
The renal effects of Bothrops jararacussu venom and the role of PLA(2) and PAF blockers.
    Toxicon : official journal of the International Society on Toxinology, 2001, Volume: 39, Issue:12

    Topics: Animals; Antigens, Human Platelet; Azepines; Biological Transport; Bothrops; Crotalid Venoms; Dexamethasone; Dose-Response Relationship, Drug; Drug Combinations; Female; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Male; Perfusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Potassium; Pressure; Rats; Rats, Wistar; Renal Circulation; Sodium; Triazoles; Urination; Urodynamics

2001
Effects of platelet activating factor antagonist (BN50739) on gut mucosal injury in acute severe pancreatitis in pigs.
    Chinese medical journal, 2000, Volume: 113, Issue:8

    Topics: Acute Disease; Animals; Azepines; Intestinal Mucosa; Pancreatitis; Platelet Activating Factor; Swine; Triazoles

2000
Participation of prostaglandin E2 and platelet-activating factor in thapsigargin-induced production of interleukin-6.
    European journal of pharmacology, 2002, Jan-11, Volume: 434, Issue:3

    Topics: Acetyltransferases; Acyl-Carrier Protein S-Acetyltransferase; Animals; Azepines; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Furans; Imidazoles; Indomethacin; Interleukin-6; Macrophages, Peritoneal; Male; Organophosphorus Compounds; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Thapsigargin; Triazoles

2002
Anti-CD44 monoclonal antibody (IM7) induces murine systemic shock mediated by platelet activating factor.
    Journal of autoimmunity, 2002, Volume: 18, Issue:1

    Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antibodies, Monoclonal; Azepines; Capillary Permeability; Cyproheptadine; Diphenhydramine; Erythrocytes; Hyaluronan Receptors; Hypotension; Immunoglobulin Fab Fragments; Immunoglobulin G; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Platelet Activating Factor; Triazoles

2002
In vitro evaluation of the role of platelet-activating factor and interleukin-8 in Mannheimia haemolytica-induced bovine pulmonary endothelial cell injury.
    American journal of veterinary research, 2002, Volume: 63, Issue:3

    Topics: Animals; Azepines; Cattle; Cattle Diseases; Cell Adhesion; Cell Degranulation; Coculture Techniques; Endothelium, Vascular; Female; Interleukin-8; Macrophages, Alveolar; Mannheimia haemolytica; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Superoxides; Triazoles

2002
Specific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:7

    Topics: Animals; Antineoplastic Agents; Azepines; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Histones; HL-60 Cells; Humans; K562 Cells; Kinetics; Leukemia; Leukemia, Erythroblastic, Acute; Mice; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Triazoles; Tumor Cells, Cultured

2002
PAF antagonist treatment reduces pro-inflammatory cytokine mRNA after spinal cord injury.
    Neuroreport, 2002, Jan-21, Volume: 13, Issue:1

    Topics: Animals; Azepines; Cytokines; Female; Inflammation Mediators; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Long-Evans; RNA, Messenger; Spinal Cord Injuries; Thoracic Vertebrae; Time Factors; Triazoles

2002
Platelet-activating factor induces cell death in cultured astrocytes and oligodendrocytes: involvement of caspase-3.
    Glia, 2002, Volume: 38, Issue:3

    Topics: Animals; Animals, Newborn; Antigens, Differentiation; Astrocytes; Azepines; Caspase 3; Caspases; Cell Death; Cells, Cultured; Central Nervous System; Diterpenes; Dose-Response Relationship, Drug; Free Radical Scavengers; Ginkgolides; Glial Fibrillary Acidic Protein; Inflammation; Lactones; Mice; Mice, Inbred CBA; Oligodendroglia; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Spinal Cord Injuries; Triazoles

2002
Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes.
    Prostaglandins & other lipid mediators, 2002, Volume: 67, Issue:3-4

    Topics: Animals; Azepines; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; L-Lactate Dehydrogenase; Lung; Male; Phosphatidylcholines; Platelet Activating Factor; Protein Kinase C; Rats; Rats, Wistar; Stimulation, Chemical; Time Factors; Triazoles

2002
Evaluation of lipopolysaccharide-induced activation of equine neutrophils.
    American journal of veterinary research, 2002, Volume: 63, Issue:6

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Azepines; CD11 Antigens; CD18 Antigens; Cell Degranulation; Complement System Proteins; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flow Cytometry; Horses; Interleukin-8; Lipopolysaccharides; Neutrophil Activation; Neutrophils; Pentoxifylline; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles; Tumor Necrosis Factor-alpha

2002
Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages.
    Biochimica et biophysica acta, 2002, Jun-13, Volume: 1583, Issue:1

    Topics: Animals; Azepines; Base Sequence; Cells, Cultured; DNA Primers; Hydrolysis; Imidazoles; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Organophosphorus Compounds; Phosphorylation; Piperidines; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Thapsigargin; Triazoles

2002
Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:2

    Topics: Azepines; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Fatty Acids, Omega-3; Humans; Intercellular Adhesion Molecule-1; Monocytes; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thienopyridines; Triazoles; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2002
Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2002, Volume: 16, Issue:3

    Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Azepines; Bile Ducts; Caco-2 Cells; Carbon Radioisotopes; Humans; Intestinal Mucosa; Male; Mice; Mice, Knockout; Platelet Activating Factor; Tissue Distribution; Triazoles

2002
Platelet-activating factor does not mediate circulatory failure induced by 35-GHz microwave heating.
    Methods and findings in experimental and clinical pharmacology, 2002, Volume: 24, Issue:5

    Topics: Animals; Azepines; Fever; Hemodynamics; Hypotension; Male; Microwaves; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Triazoles

2002
Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B).
    The Journal of biological chemistry, 2002, Nov-22, Volume: 277, Issue:47

    Topics: Animals; Azepines; Cell Line; Female; Interleukin-1; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Platelet Activating Factor; Pyridinium Compounds; Receptors, Interleukin-1; Signal Transduction; Time Factors; Triazoles; Tumor Necrosis Factor-alpha

2002
Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats.
    Psychopharmacology, 2002, Volume: 163, Issue:3-4

    Topics: Animals; Azepines; Diterpenes; Dose-Response Relationship, Drug; Formaldehyde; Ginkgolides; Inflammation; Lactones; Male; Pain; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thienopyridines; Time Factors; Triazoles

2002
Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10.
    Critical care medicine, 2002, Volume: 30, Issue:10

    Topics: Arachidonic Acid; Autocrine Communication; Azepines; Escherichia coli; Humans; In Vitro Techniques; Indoles; Interleukin-10; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipopolysaccharide Receptors; Lipopolysaccharides; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Prospective Studies; Respiratory Burst; Superoxides; Triazoles

2002
In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock.
    Shock (Augusta, Ga.), 2002, Volume: 18, Issue:5

    Topics: Animals; Azepines; Cell Adhesion; Endothelium, Vascular; Fluorescent Dyes; Leukocytes; Lymphocyte Function-Associated Antigen-1; Male; Microcirculation; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Resuscitation; Rhodamines; Shock, Hemorrhagic; Triazoles

2002
Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces.
    The Journal of laboratory and clinical medicine, 2002, Volume: 140, Issue:5

    Topics: Animals; Azepines; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cell Count; Endothelium, Vascular; Hydrogen Peroxide; Intercellular Junctions; Intubation, Intratracheal; Lung; Male; Neutrophils; NF-kappa B; Peroxidase; Platelet Activating Factor; Pneumonia; Rats; Rats, Sprague-Dawley; Triazoles

2002
Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation.
    Acta pharmacologica Sinica, 2003, Volume: 24, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Azepines; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Drug Synergism; Epinephrine; Flurbiprofen; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Signal Transduction; Triazoles; Verapamil; Yohimbine

2003
A new method to evaluate spontaneous platelet aggregation in type 2 diabetes by Cellfacts.
    Clinica chimica acta; international journal of clinical chemistry, 2003, Volume: 329, Issue:1-2

    Topics: Adenosine Diphosphate; Antioxidants; Azepines; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Triazoles; Vitamin E

2003
Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C.
    Surgical infections, 2001,Winter, Volume: 2, Issue:4

    Topics: Adolescent; Adult; Aged; Apoptosis; Azepines; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Injury Severity Score; Maleimides; Middle Aged; Neutrophils; Phospholipids; Plasma; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Signal Transduction; Time Factors; Triazoles; Wounds and Injuries

2001
Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4.
    Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 94, Issue:6

    Topics: Animals; Azepines; Capillary Permeability; Cell Adhesion; Fluorescence; Hypoxia; Leukocytes; Leukotriene B4; Male; Microcirculation; Oxidants; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Rhodamines; Splanchnic Circulation; Triazoles; Vasculitis

2003
The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:4

    Topics: Animals; Antigens; Azepines; Capillary Permeability; Conjunctivitis, Allergic; Disease Models, Animal; Dose-Response Relationship, Drug; Dye Dilution Technique; Guinea Pigs; Humans; Immunization, Passive; Ketotifen; Male; Ophthalmic Solutions; Platelet Activating Factor; Pruritus; Time Factors; Triazoles

2003
Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Nov-15, Volume: 171, Issue:10

    Topics: Animals; Antibodies, Monoclonal; Azepines; CD40 Antigens; CD40 Ligand; Cell Communication; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Endothelium, Vascular; Female; Humans; Injections, Subcutaneous; Intracellular Fluid; Laminin; Mice; Mice, Inbred C57BL; Models, Immunological; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteoglycans; Receptors, G-Protein-Coupled; Triazoles

2003
Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility.
    Cardiovascular research, 2003, Nov-01, Volume: 60, Issue:2

    Topics: Animals; Azepines; Class Ib Phosphatidylinositol 3-Kinase; Female; In Vitro Techniques; Isoenzymes; Mice; Mice, Knockout; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Perfusion; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles

2003
Candidate's thesis: Platelet-activating factor-induced hearing loss: mediated by nitric oxide?
    The Laryngoscope, 2003, Volume: 113, Issue:12

    Topics: Animals; Azepines; Cochlea; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; Immunohistochemistry; Longitudinal Studies; Microscopy, Electron, Scanning; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Activating Factor; Random Allocation; Round Window, Ear; Triazoles

2003
Effect of inhibitors of leukotriene and/or platelet activating factor on killed H. influenzae induced experimental otitis media with effusion.
    International journal of pediatric otorhinolaryngology, 2004, Volume: 68, Issue:1

    Topics: Animals; Arachidonic Acid; Azepines; Case-Control Studies; Chinchilla; Chromatography, High Pressure Liquid; Haemophilus influenzae; Injections, Intraperitoneal; Leukotriene Antagonists; Leukotrienes; Naphthyridines; Otitis Media with Effusion; Platelet Activating Factor; Platelet Aggregation Inhibitors; Random Allocation; Temporal Bone; Triazoles

2004
The role of platelet activating factor in a neonatal piglet model of necrotising enterocolitis.
    Gut, 2004, Volume: 53, Issue:2

    Topics: Animals; Animals, Newborn; Azepines; Blood Gas Analysis; Blood Pressure; Enterocolitis, Necrotizing; Hypoxia; Intestinal Mucosa; Lipopolysaccharides; Mesenteric Arteries; Models, Animal; Platelet Activating Factor; Regional Blood Flow; Swine; Triazoles; Vascular Resistance

2004
Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells.
    The Annals of otology, rhinology, and laryngology, 2004, Volume: 113, Issue:2

    Topics: Albumins; Animals; Azepines; Chinchilla; Hair Cells, Auditory, Outer; Platelet Activating Factor; Sodium Chloride; Triazoles

2004
Left regional cardiac perfusion in vitro with platelet-activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous "mediators" facilitated by interactions, and moderated by paradoxical antago
    British journal of pharmacology, 2004, Volume: 142, Issue:2

    Topics: Animals; Azepines; Coronary Vessels; Heart Ventricles; In Vitro Techniques; Male; Myocardial Ischemia; Norepinephrine; Perfusion; Platelet Activating Factor; Potassium; Rats; Rats, Wistar; Triazoles; Ventricular Fibrillation; Ventricular Function

2004
Determination of specific receptor sites for platelet activating factor in bovine neutrophils.
    American journal of veterinary research, 2004, Volume: 65, Issue:5

    Topics: Animals; Azepines; Base Sequence; Blotting, Western; Cattle; Cyclooctanes; Diterpenes; DNA Primers; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Ginkgolides; HL-60 Cells; Humans; Kinetics; Lactones; Lignans; Molecular Sequence Data; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polycyclic Compounds; Radioligand Assay; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Triazoles; Tritium

2004
Involvement of platelet activating factor in immediate heart response to lipopolysaccharide.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004, Volume: 55, Issue:2

    Topics: Animals; Azepines; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Escherichia coli; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phospholipid Ethers; Platelet Activating Factor; Rats; Receptors, Leukotriene; Receptors, Thromboxane A2, Prostaglandin H2; Triazoles

2004
Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs.
    Journal of pharmacological sciences, 2004, Volume: 95, Issue:4

    Topics: Administration, Topical; Animals; Azepines; Chronic Disease; Conjunctiva; Conjunctivitis, Allergic; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Eosinophils; Guinea Pigs; Male; Ophthalmic Solutions; Ovalbumin; Platelet Activating Factor; Tears; Triazoles

2004
Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells.
    Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:9

    Topics: Animals; Antibodies; Azepines; Cattle; Cell Division; Cell Movement; Cells, Cultured; Corneal Neovascularization; Dose-Response Relationship, Drug; Endothelial Cells; Fibroblast Growth Factor 2; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; RNA, Messenger; Skin; Thienopyridines; Triazoles; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A

2004
Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:5

    Topics: Alkaloids; Animals; Azepines; Benzophenanthridines; Cardiotonic Agents; Chromones; Coronary Circulation; Enzyme Inhibitors; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Morpholines; Myocardial Reperfusion Injury; Myocardium; Necrosis; Perfusion; Phenanthridines; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Rats; Rats, Wistar; Triazoles; Ventricular Function, Left

2005
Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils.
    American journal of respiratory cell and molecular biology, 2006, Volume: 34, Issue:6

    Topics: Adult; Antibodies, Monoclonal; Asthma; Azepines; Basement Membrane; Chemotaxis, Leukocyte; Coculture Techniques; Collagen; Culture Media, Conditioned; Drug Combinations; Eosinophils; Humans; Interleukin-8; Laminin; Leukotriene B4; Matrix Metalloproteinase 9; Neutrophil Activation; Neutrophils; Paracrine Communication; Platelet Activating Factor; Protease Inhibitors; Proteoglycans; Pulmonary Eosinophilia; Triazoles; Tumor Necrosis Factor-alpha

2006
Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086.
    British journal of cancer, 2006, Jun-05, Volume: 94, Issue:11

    Topics: Azepines; Breast Neoplasms; Cathepsin D; Cell Cycle; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Movement; Humans; Platelet Activating Factor; Triazoles

2006
Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor.
    Immunology, 2006, Volume: 118, Issue:2

    Topics: Animals; Azepines; Cell Line; Chemokine CXCL2; Chemokines, CXC; Dose-Response Relationship, Immunologic; Electrophoretic Mobility Shift Assay; Enterocytes; Gene Expression Regulation; I-kappa B Proteins; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Platelet Activating Factor; Pyrrolidines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Triazoles; Tumor Necrosis Factor-alpha

2006
WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph.
    Journal of insect physiology, 2006, Volume: 52, Issue:7

    Topics: Animals; Azepines; Catechol Oxidase; Enzyme Precursors; Hemocytes; Hemolymph; Larva; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rhodnius; Triazoles; Trypanosoma

2006
Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor.
    European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3

    Topics: Analgesics; Animals; Anisoles; Anti-Inflammatory Agents; Azepines; Binding, Competitive; Carrageenan; Cerebral Cortex; Dioxoles; Inflammation; Lignans; Male; Mice; Pain Measurement; Pain Threshold; Peroxidase; Phyllanthus; Plant Extracts; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pleurisy; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Tetrahydronaphthalenes; Time Factors; Triazoles

2006
Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line.
    Prostaglandins & other lipid mediators, 2006, Volume: 81, Issue:3-4

    Topics: Animals; Azepines; Cell Movement; Collagen; Culture Media, Conditioned; Drug Combinations; Interferon-gamma; Laminin; Melanoma; Mice; Neoplasm Invasiveness; Phenotype; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Proteoglycans; Receptors, G-Protein-Coupled; Stress Fibers; Time Factors; Triazoles; Tumor Cells, Cultured

2006
Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2007, Volume: 7, Issue:1

    Topics: Acute Disease; Animals; Azepines; Candida albicans; Kupffer Cells; Lipopolysaccharides; Liver; Male; Nitric Oxide; Pancreatitis; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Taurocholic Acid; Triazoles; Tumor Necrosis Factors

2007
Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice.
    Chinese medical journal, 2007, May-20, Volume: 120, Issue:10

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Azepines; Capillaries; Cholesterol; Hindlimb; Ischemia; Lipoproteins, LDL; Male; Mice; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles

2007
Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor.
    Cellular signalling, 2007, Volume: 19, Issue:10

    Topics: Animals; Azepines; Chlorocebus aethiops; COS Cells; Down-Regulation; Lysosomes; Platelet Activating Factor; Platelet Membrane Glycoproteins; Proteasome Inhibitors; Protein Kinase C; Protein Transport; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles

2007
The effects of platelet-activating factor on the secretion of interleukin-8 and growth-regulated oncogene alpha in human immortalized granulosa cell line (GC1a).
    American journal of reproductive immunology (New York, N.Y. : 1989), 2007, Volume: 58, Issue:5

    Topics: Azepines; Cell Line; Chemokine CXCL1; Enzyme-Linked Immunosorbent Assay; Female; Granulosa Cells; Humans; Interleukin-8; Ovulation; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles

2007
Blockades of phospholipase A(2) and platelet-activating factor receptors reduce the hemocyte phagocytosis in Rhodnius prolixus: in vitro experiments.
    Journal of insect physiology, 2008, Volume: 54, Issue:2

    Topics: Animals; Azepines; Eicosanoids; Hemocytes; Heteroptera; Larva; Phagocytosis; Phospholipase A2 Inhibitors; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles

2008
Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses.
    American journal of veterinary research, 2008, Volume: 69, Issue:2

    Topics: Animals; Aspirin; Azepines; Benzamides; Blood Platelets; Calcimycin; Female; Horses; Leukocytes; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; Serotonin; Thromboxane A2; Time Factors; Triazoles; Tryptamines; Vasoconstriction

2008
Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases.
    Cell proliferation, 2008, Volume: 41, Issue:2

    Topics: Animals; Azepines; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; Flavonoids; Hypoxia; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; NF-kappa B; Oxygen; Platelet Activating Factor; Pulmonary Artery; Pulmonary Veins; Sheep; Structure-Activity Relationship; Triazoles

2008
Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity.
    Pancreas, 2009, Volume: 38, Issue:1

    Topics: Amylases; Animals; Azepines; Capillaries; Cell Adhesion; Ceruletide; Disease Models, Animal; Edema; Female; Glycodeoxycholic Acid; Leukocytes; Microcirculation; Oligopeptides; Pancreas; Pancreatitis; Pancreatitis, Acute Necrotizing; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Regional Blood Flow; Severity of Illness Index; Taurocholic Acid; Time Factors; Triazoles

2009
Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure.
    Chemical biology & drug design, 2008, Volume: 72, Issue:3

    Topics: Anti-Inflammatory Agents; Antifungal Agents; Cells, Cultured; Fluconazole; Humans; Imidazoles; Itraconazole; Ketoconazole; Leukotriene B4; Molecular Structure; Neutrophils; Platelet Activating Factor; Pyrimidines; Triazoles; Voriconazole

2008
Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw.
    Biochemical pharmacology, 2009, Apr-01, Volume: 77, Issue:7

    Topics: Animals; Azepines; Forelimb; Male; Pain; Pain Measurement; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Triazoles

2009
Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 64, Issue:5

    Topics: Adult; Anti-Inflammatory Agents; Calcium; Humans; Immunoassay; Immunologic Factors; Leukotriene B4; Neutrophils; Platelet Activating Factor; Spectrometry, Fluorescence; Triazoles; Young Adult

2009
Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010, Volume: 24, Issue:2

    Topics: Animals; Azepines; Cell Movement; Dihydropyridines; Female; Flagellin; Humans; Imidazoles; Leukotriene B4; Ligands; Mice; Mice, Inbred C57BL; Neutrophils; Platelet Activating Factor; Poly I-C; Propionates; Quinolines; Thienopyridines; Toll-Like Receptors; Triazoles

2010
Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Jun-01, Volume: 184, Issue:11

    Topics: Animals; Azepines; Cell Degranulation; Eosinophils; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles

2010
Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages.
    PloS one, 2010, Nov-03, Volume: 5, Issue:11

    Topics: Amino Acid Chloromethyl Ketones; Animals; Antibodies; Azepines; Cell Communication; Cells, Cultured; Coculture Techniques; Cytokines; Female; Host-Parasite Interactions; Leishmania; Leukocyte Elastase; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Microscopy, Fluorescence; Neutrophils; Nitric Oxide; Platelet Activating Factor; Reactive Oxygen Species; Triazoles; Tumor Necrosis Factor-alpha

2010
Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets.
    Arzneimittel-Forschung, 2010, Volume: 60, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Benzimidazoles; Chemotaxis, Leukocyte; Cloning, Molecular; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Ferrets; Guinea Pigs; Humans; Inflammation; Lipopolysaccharides; Male; Nitriles; Phosphodiesterase 4 Inhibitors; Platelet Activating Factor; Rats; Rats, Inbred BN; Rats, Inbred Lew; Respiratory Tract Diseases; Tissue Distribution; Triazoles; Tumor Necrosis Factor-alpha; Vomiting

2010
Effects of platelet-activating factor on the interaction of Trypanosoma cruzi with Rhodnius prolixus.
    Parasitology research, 2011, Volume: 108, Issue:6

    Topics: Animals; Azepines; Chagas Disease; Host-Parasite Interactions; N-Acetylneuraminic Acid; Neuraminidase; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rhodnius; Triazoles; Trypanosoma cruzi

2011
Noninvasive molecular imaging reveals role of PAF in leukocyte-endothelial interaction in LPS-induced ocular vascular injury.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011, Volume: 25, Issue:4

    Topics: Animals; Azepines; Ginkgolides; Lactones; Leukocyte Rolling; Lipopolysaccharides; Male; Membrane Glycoproteins; Molecular Imaging; Platelet Activating Factor; Rats; Rats, Inbred Lew; Triazoles; Uveitis

2011
Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011, Volume: 60, Issue:8

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Azepines; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Imidazoles; Lipopolysaccharides; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles

2011
Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:6

    Topics: Acidosis; Alkalosis; Animals; Azepines; Benzophenanthridines; Dose-Response Relationship, Drug; Flavonoids; Guanidines; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; Indoles; Ion Transport; Maleimides; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Kinase Inhibitors; Receptors, G-Protein-Coupled; Signal Transduction; Sodium; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Sulfones; Time Factors; Triazoles

2011
Albuterol isomers modulate platelet-activating factor synthesis and receptor signaling in human bronchial smooth muscle cells.
    International archives of allergy and immunology, 2012, Volume: 158, Issue:1

    Topics: Albuterol; Azepines; Bronchi; Bronchodilator Agents; Cell Line; Cell Proliferation; Humans; Inositol 1,4,5-Trisphosphate; Myocytes, Smooth Muscle; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles

2012
Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor.
    Journal of inorganic biochemistry, 2013, Volume: 120

    Topics: Animals; Azepines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Dynamics Simulation; Organometallic Compounds; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rhodium; Structure-Activity Relationship; Thrombin; Triazoles

2013
Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Actins; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Cyclosporine; Cytochalasin B; Cytoskeleton; Gelsolin; Humans; Marine Toxins; NADPH Oxidases; Neutrophils; Oligopeptides; Oxazoles; Peptide Fragments; Platelet Activating Factor; Receptors, Formyl Peptide; Superoxides; Thiazolidines; Triazoles

2013
Cooperative role of endogenous leucotrienes and platelet-activating factor in ischaemia-reperfusion-mediated tissue injury.
    Journal of cellular and molecular medicine, 2013, Volume: 17, Issue:12

    Topics: Amidines; Animals; Azepines; Biological Assay; Carbamates; Dermis; Disease Models, Animal; Extravasation of Diagnostic and Therapeutic Materials; Extremities; Inflammation; Leukotriene B4; Leukotrienes; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Neutrophil Infiltration; Platelet Activating Factor; Platelet Membrane Glycoproteins; Propionates; Quinolines; Rabbits; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Reperfusion Injury; Triazoles

2013
Central role of PAFR signalling in ExoU-induced NF-κB activation.
    Cellular microbiology, 2014, Volume: 16, Issue:8

    Topics: Animals; Azepines; Bacterial Proteins; Bacterial Toxins; Cell Line; Enzyme Activation; Female; Gene Expression Regulation; Humans; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Promoter Regions, Genetic; Protein Binding; Pseudomonas aeruginosa; Pseudomonas Infections; Receptors, G-Protein-Coupled; Signal Transduction; Transcription Factor RelA; Triazoles

2014
Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi.
    PLoS neglected tropical diseases, 2014, Volume: 8, Issue:8

    Topics: Animals; Azepines; Lysophosphatidylcholines; Models, Molecular; Molecular Docking Simulation; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Rabbits; Receptors, G-Protein-Coupled; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triazoles; Trypanosoma cruzi

2014
Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells.
    Molecular medicine reports, 2015, Volume: 12, Issue:1

    Topics: Animals; Apoptosis; Azepines; Cell Line; Cell Proliferation; Gene Expression Regulation; Humans; Isothiocyanates; Melanoma; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Reactive Oxygen Species; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles

2015
Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs.
    American journal of veterinary research, 2016, Volume: 77, Issue:9

    Topics: Animals; Azepines; Dogs; Edema; Erythema; Histamine; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Prednisolone; Receptors, G-Protein-Coupled; Skin; Skin Diseases; Triazoles

2016
Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF.
    Journal of lipid research, 2018, Volume: 59, Issue:11

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Chromatography, Liquid; Female; Healthy Volunteers; Lysophosphatidylcholines; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles

2018
Human mesenchymal stem cells in the tumour microenvironment promote ovarian cancer progression: the role of platelet-activating factor.
    BMC cancer, 2018, Oct-19, Volume: 18, Issue:1

    Topics: Animals; Azepines; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Disease Progression; Female; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Triazoles; Tumor Microenvironment

2018
Effect of Platelet-Activating Factor on Barrier Function of ARPE-19 Cells.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: Azepines; Cadherins; Cell Line; Cell Membrane Permeability; Electric Impedance; Humans; Neovascularization, Physiologic; Platelet Activating Factor; Platelet Aggregation Inhibitors; Retinal Pigment Epithelium; Tight Junctions; Triazoles; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein

2020