Page last updated: 2024-12-07

n-iodosuccinimide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

N-Iodosuccinimide (NIS) is a versatile reagent used in organic synthesis. It is a white, crystalline solid that is soluble in organic solvents. NIS is typically prepared by reacting succinimide with iodine in the presence of a base. It serves as a mild and selective electrophilic iodinating reagent, allowing for the introduction of iodine atoms into organic molecules. The reaction mechanism involves the formation of an iodonium ion, which then attacks the substrate. NIS is often used in the synthesis of iodinated compounds, which have various applications in medicine, agriculture, and materials science. For instance, iodinated compounds are used as radiopharmaceuticals for diagnostic imaging, as pesticides, and as components in polymers. The unique reactivity of NIS, allowing for selective iodine incorporation, makes it an essential tool for organic chemists in developing new synthetic methods and exploring the properties of diverse iodinated compounds. NIS is particularly important in the synthesis of complex natural products and pharmaceuticals.'

Cross-References

ID SourceID
PubMed CID120273
CHEBI ID53204
SCHEMBL ID18779
MeSH IDM0051755

Synonyms (51)

Synonym
AC-534
1-iodo-pyrrolidine-2,5-dione
NIS ,
516-12-1
n-iodosuccinimide, 95%
1-iodopyrrolidine-2,5-dione
succiniodimide
n-iodosuccinimide ,
brn 0113917
succinimide, n-iodo-
einecs 208-221-6
2,5-pyrrolidinedione, 1-iodo-
CHEBI:53204
I0074
AKOS009156901
n-iodo succinimide
A828685
c4h4ino2
unii-3cos3x3n4p
3cos3x3n4p ,
5-21-09-00544 (beilstein handbook reference)
FT-0632267
AM20100260
n-iodosuccinimide (nis)
BP-21328
SCHEMBL18779
n-iodosuccinimide [mi]
1-iodo-2,5-pyrrolidinedione
n-iodosuccinimid
n-iodopyrrolidin-2,5-dione
n-iodosuccinic acid imide
LQZMLBORDGWNPD-UHFFFAOYSA-N
n-iodsuccinimide
n-iodosuccinirnide
n-iodo-succinimide
W-202947
STR02991
mfcd00005512
F0001-1344
DTXSID10199550
CS-W008878
n-iodosuccinimide, purum, >=97.0% (rt)
P16496
SY001605
BCP18538
Q27124017
STL191537
n-jod-succinimid
n-iodosuccinimide; nbs content < 0.1%
PB48800
EN300-52551
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
dicarboximideAn imide in which the two acyl substituents on nitrogen are carboacyl groups.
pyrrolidinone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (60)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (3.33)18.2507
2000's17 (28.33)29.6817
2010's38 (63.33)24.3611
2020's3 (5.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 106.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index106.82 (24.57)
Research Supply Index4.11 (2.92)
Research Growth Index5.27 (4.65)
Search Engine Demand Index189.95 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (106.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other60 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]