3-methyl-s-triazolo(3,4-a)phthalazine profile

3-methyl-s-triazolo(3,4-a)phthalazine: metabolite of hydralazine; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

3-methyl-1,2,4-triazolo[3,4-a]phthalazine : A 1,2,4-triazolo[3,4-a]phthalazine having a methyl substituent at the 3-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	97339
CHEBI ID	60480
MeSH ID	M0052414

Synonyms (25)

Synonym
1,4-triazolo[3,4-a]phthalazine, 3-methyl-
s-triazolo[3, 3-methyl-
nsc116346
nsc-116346
20062-41-3
3-methyltriazolophthalazine
3-methyl-1,2,4-triazolo[3,4-a]phthalazine
CHEBI:60480 ,
3-methyl-s-triazolo[3,4-a]phthalazine
3-methyl[1,2,4]triazolo[3,4-a]phthalazine
3-methyl-[1,2,4]triazolo[3,4-a]phthalazine
AKOS006271459
nsc 116346
03760vrh6p ,
unii-03760vrh6p
s-triazolo(3,4-a)phthalazine, 3-methyl-
3-methyl-s-triazolo(3,4-a)phthalazine
1,2,4-triazolo(3,4-a)phthalazine, 3-methyl-
FT-0672245
EPITOPE ID:137350
3-methyltriazolo(3,4-a)phthalazine
DTXSID90173878
1,2,4-triazolo[3,4-a]phthalazine, 3-methyl-
J-012987
Q27127311

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" All the hydrazones studied had an effective hypotensive effect after a high dosing (10 mg/kg); however, their potency was much smaller than that of HP, when plasma-free concentration-response curves were compared."	( Pharmacokinetics of formation and excretion of some metabolites of hydralazine and their hypotensive effect in rats. Iwaki, M; Ogiso, T; Ohtsuki, N, 1985)	0.27

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
triazolophthalazine	An organic heterotricyclic compound comprising a triazole ring fused to a phthalazine ring system.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (80.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.23 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.31 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.23)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
hydralazine Hydralazine: A direct-acting vasodilator that is used as an antihypertensive agent.. hydralazine : The 1-hydrazino derivative of phthalazine; a direct-acting vasodilator that is used as an antihypertensive agent.	3.06	5	0	azaarene; hydrazines; ortho-fused heteroarene; phthalazines	antihypertensive agent; vasodilator agent
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2.65	3	0	1,2,3-triazole

Condition	Indicated	Relationship Strength	Studies	Trials
Blood Pressure, High [description not available]	0	1.96	1	0
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	0	1.96	1	0

3-methyl-s-triazolo(3,4-a)phthalazine

Description