nitenpyram: a nitromethylene neonicotinoid insecticide; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
(E)-nitenpyram : A nitenpyram in which the double bond has E configuration. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
nitenpyram : A C-nitro compound consisting of 2-nitroethene-1,1-diamine where one of the nitrogens bears ethyl and (6-chloro-3-pyridinyl)methyl while the other nitrogen carries a methyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 3034287 |
| CHEMBL ID | 259728 |
| CHEBI ID | 39171 |
| CHEBI ID | 39170 |
| SCHEMBL ID | 25789 |
| SCHEMBL ID | 25788 |
| MeSH ID | M0438113 |
| Synonym |
|---|
| 1,1-ethenediamine, n-((6-chloro-3-pyridinyl)methyl)-n-ethyl-n'-methyl-2-nitro-, (1e)- |
| nitenpyram [iso] |
| NCGC00166149-01 |
| (e)-nitenpyram |
| nitenpyram |
| 150824-47-8 |
| (1e)-n-((6-chloro-3-pyridinyl)methyl)-n-ethyl-n'-methyl-2-nitro-1,1-ethenediamine |
| n-[(6-chloropyridin-3-yl)methyl]-n-ethyl-n'-methyl-2-nitroethene-1,1-diamine |
| CHEBI:39171 , |
| ti 304 |
| CHEBI:39170 , |
| (e)-n-[(6-chloropyridin-3-yl)methyl]-n-ethyl-n'-methyl-2-nitroethene-1,1-diamine |
| n-((6-chloropyridin-3-yl)methyl)-n-ethyl-n'-methyl-2-nitroethene-1,1-diamine |
| (e)-n-(6-chloro-3-pyridylmethyl)-n-ethyl-n'-methyl-2-nitrovinylidenediamine |
| CHEMBL259728 |
| (e)-1-n'-[(6-chloropyridin-3-yl)methyl]-1-n'-ethyl-1-n-methyl-2-nitroethene-1,1-diamine |
| A809078 |
| n1-[(6-chloro-3-pyridyl)methyl]-n1'-ethyl-n1'-methyl-2-nitro-ethene-1,1-diamine |
| (e)-n1'-[(6-chloro-3-pyridyl)methyl]-n1'-ethyl-n1-methyl-2-nitro-ethene-1,1-diamine;nitenpyram |
| A804578 |
| 120738-89-8 |
| C18511 |
| 3a837vz81y , |
| capstar |
| hsdb 8491 |
| (e)-n-(6-chloro-3-pyridylmethyl)-n-ethyl-n2-methyl-2-nitrovinylidenediamine |
| bestguard |
| unii-3a837vz81y |
| niterndipoine |
| (1e)-n-((6-chloro-3-pyridinyl)methyl]-n-ethyl-n2-methyl-2-nitro-1,1-ethenediamine |
| 1,1-ethenediamine, n-((6-chloro-3-pyridinyl)methyl)-n-ethyl-n-methyl-2-nitro- |
| tox21_112342 |
| dtxcid6021080 |
| dtxsid8041080 , |
| cas-150824-47-8 |
| (1e)-n-[(6-chloro-3-pyridinyl)methyl]-n-ethyl-n'-methyl-2-nitro-1,1-ethenediamine |
| (e)-n-(6-chloro-3-pyridylmethyl)-n-ethyl-n'-methyl-2-nitroethylene-1,1-diamine |
| AKOS015914907 |
| nitenpyram [green book] |
| nitenpyram [mi] |
| SCHEMBL25789 |
| SCHEMBL25788 |
| tox21_112342_1 |
| NCGC00166149-02 |
| (e)-n-((6-chloropyridin-3-yl)methyl)-n-ethyl-n'-methyl-2-nitroethene-1,1-diamine |
| Q-201476 |
| CFRPSFYHXJZSBI-DHZHZOJOSA-N |
| n-[(6-chloro-3-pyridinyl)methyl]-n-ethyl-n'-methyl-2-nitro-1,1-ethenediamine |
| KS-5369 |
| 1,1-ethenediamine, n-[(6-chloro-3-pyridinyl)methyl]-n-ethyl-n'-methyl-2-nitro-, (1e)- |
| mfcd01631161 |
| n-((6-chloropyridin-3-yl)methyl)-n-ethyl-n-methyl-2-nitroethene-1,1-diamine |
| [(e)-1-{[(6-chloropyridin-3-yl)methyl](ethyl)amino}-2-nitroethenyl](methyl)amine |
| nitenpyram, pestanal(r), analytical standard |
| bdbm50486236 |
| nitenpyram 10 microg/ml in acetonitrile |
| (e)-n-((6-chloropyridin-3-yl)methyl)-n-ethyl-n-methyl-2-nitroethene-1,1-diamine |
| CS-0012837 |
| HY-B0820 |
| Q3817186 |
| S4422 |
| DB11438 |
| Q27119765 |
| A14229 |
| HMS3885B06 |
| CCG-267169 |
| capaction |
| (1e)-n-((6-chloro-3-pyridinyl)methyl)-n-ethyl-n2-methyl-2-nitro-1,1-ethenediamine |
| dtxcid40819956 |
| petarmor capaction |
Nitenpyram is one of the most commonly used neonicotinoid pesticide worldwide and was found to be toxic to non-target aquatic organisms. Little knowledge is available on the adverse effects to human health, with some evidence referring to its genotoxic potency toNon-target organisms and esophageal squamous papilloma in rats.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Nitenpyram is one of the most commonly used neonicotinoid pesticide worldwide and was found to be toxic to non-target aquatic organisms." | ( Toxic effects of nitenpyram on antioxidant enzyme system and DNA in zebrafish (Danio rerio) livers. Chen, A; Wang, J; Yan, S; Zhu, L, 2015) | 0.42 |
| " Chlorfenapyr was the most toxic adulticide among all the tested insecticides." | ( Toxicity of 25 synthetic insecticides to the field population of Culex quinquefasciatus Say. Ahmad, D; Alam, M; Ali, Q; Binyamin, M; Shad, SA; Shah, RM; Waqas, M, 2016) | 0.43 |
| " The responsiveness of these immune indicators provides new insight into and evidence of the adverse effects of neonicotinoids on aquatic non-target organisms." | ( Changes of hematological and biochemical parameters revealed genotoxicity and immunotoxicity of neonicotinoids on Chinese rare minnows (Gobiocypris rarus). Hong, X; Li, J; Tian, X; Zha, J; Zhao, X, 2018) | 0.48 |
| " In this study, the toxic effect of imidacloprid and nitenpyram on the brain of juvenile Chinese rare minnows (Gobiocypris rarus) was investigated by determining the oxidative stress, 8-hydroxy-2-deoxyguanosine (8-OHdG) content and acetylcholinesterase (AChE) activity." | ( Chronic brain toxicity response of juvenile Chinese rare minnows (Gobiocypris rarus) to the neonicotinoid insecticides imidacloprid and nitenpyram. Ge, C; He, L; Huang, Z; Jiao, W; Li, X; Lin, A; Ma, L; Tian, X; Wang, D; Yang, W; Yao, R; Zhao, Y, 2018) | 0.48 |
| " The toxic effects of nitenpyram on earthworms were combined with the method called the second-generation integrated biomarker response index method (IBRv2) to be comprehensively analyzed by studying the reactive oxygen species (ROS) content, superoxide dismutase (SOD) activity, catalase (CAT) activity, glutathione S-transferase (GST) activity, malondialdehyde (MDA) content and DNA damage degree in earthworms." | ( Oxidative stress and genotoxicity of nitenpyram to earthworms (Eisenia foetida). Chen, Y; Kim, YM; Wang, G; Wang, J; Xia, X; Zhang, W; Zhu, L, 2021) | 0.62 |
| "Despite of the global contamination and ubiquitous exposure to nitenpyram (NIT), little knowledge is available on the adverse effects to human health, with some evidence referring to its genotoxic potency to non-target organisms and esophageal squamous papilloma in rats." | ( Genotoxicity, oxidative stress and transcriptomic effects of Nitenpyram on human bone marrow mesenchymal stem cells. Cui, X; Li, Z; Liu, W; Luo, F; Xing, L; Zhang, J; Zhou, C, 2022) | 0.72 |
| " However, few studies have reported the mechanism underlying nitenpyram's toxic effect on silkworms." | ( Toxicity of nitenpyram to silkworm (Bombyx mori L.) and its potential mechanisms. Chen, G; Chen, Q; Chen, Z; Sun, S; Wang, H; Wang, K, 2023) | 0.91 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The objective of this study was to develop analytical method based on optimized dispersive liquid-liquid microextraction (DLLME) as a pretreatment procedure combined with reversed phase liquid chromatographic separation on C18 column and isocratic elution for simultaneous MS/MS determination of selected neonicotinoid insecticides in honey." | ( Multi-residue method for determination of selected neonicotinoid insecticides in honey using optimized dispersive liquid-liquid microextraction combined with liquid chromatography-tandem mass spectrometry. Banjac, V; Franko, M; Guzsvány, V; Jovanov, P; Lazić, S; Sakač, M; Šarić, B, 2013) | 0.39 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
| Class | Description |
|---|---|
| chloropyridyl insecticide | An organochlorine insecticide based on a chloropyridyl skeleton and its derivatives. |
| nitenpyram | A C-nitro compound consisting of 2-nitroethene-1,1-diamine where one of the nitrogens bears ethyl and (6-chloro-3-pyridinyl)methyl while the other nitrogen carries a methyl group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 43.6486 | 0.0025 | 41.7960 | 15,848.9004 | AID1347398 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 16.7855 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521 |
| AR protein | Homo sapiens (human) | Potency | 26.8325 | 0.0002 | 21.2231 | 8,912.5098 | AID743036 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 (µMol) | 1,000.0000 | 0.0340 | 3.9871 | 10.0000 | AID1082239 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043 | Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46 | Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7 | High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4 | Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1104202 | Insecticidal activity against adult female imidacloprid-resistant Bemisia tabaci B-biotype NJ-Imi (sweet potato whitefly) (G30) in cotton leaf discs assessed as mortality treated for 10 secs prior to adult infestation measured after 72 hr by leaf-dip bioa | 2009 | Pest management science, Nov, Volume: 65, Issue:11 | Cross-resistance, inheritance and biochemical mechanisms of imidacloprid resistance in B-biotype Bemisia tabaci. |
| AID1082240 | Phytotoxicity against Vitis vinifera seedlings assessed as lesions at 50 to 100 ppm after 9 days | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1082231 | Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol at IC50 concentration | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1092183 | Insecticidal activity against Myzus persicae (green peach aphid) assessed as mortality at 25 degC after 72 hr | 2012 | Journal of agricultural and food chemistry, Sep-26, Volume: 60, Issue:38 | Synthesis, insecticidal activity, crystal structure, and molecular docking studies of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring. |
| AID1082244 | Phytotoxicity against Glycine max (soybean) seedlings assessed as lesions in unfoliolate leaves at 100 ppm after 9 days | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1091884 | In vivo insecticidal activity against fifth-instar larval stage of Nilaparvata lugens (brown planthopper) in second semester rice seedlings assessed as insect mortality at 100 mg/L treated for 5 secs before larval infestation measured after 72 hr | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies. |
| AID1111949 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as inhibition of honeydew excretion at LC20 concentration measured after 72 hr by dipping method | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1082232 | Inhibition of xanthine oxidase at IC50 concentration | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1112903 | Displacement of [3H]-methyl-SFX from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1082239 | Inhibition of Agaricus bisporus (mushroom) tyrosinase | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1082706 | Insecticidal activity against Empoasca (Green Leafhopper) | 2012 | Journal of agricultural and food chemistry, Jan-11, Volume: 60, Issue:1 | Design, synthesis, and particular biological behaviors of chain-opening nitromethylene neonicotinoids with cis configuration. |
| AID1092187 | Insecticidal activity against Myzus persicae (green peach aphid) assessed as mortality at 25 degC after 72 hr at 100 mg/L | 2012 | Journal of agricultural and food chemistry, Sep-26, Volume: 60, Issue:38 | Synthesis, insecticidal activity, crystal structure, and molecular docking studies of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring. |
| AID1111952 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as mortality measured after 72 hr by dipping method | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID318725 | Displacement of [3H]ACE from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-22, Volume: 104, Issue:21 | Mapping the elusive neonicotinoid binding site. |
| AID1091885 | In vivo insecticidal activity against fifth-instar larval stage of Nilaparvata lugens (brown planthopper) in second semester rice seedlings assessed as insect mortality at 500 mg/L treated for 5 secs before larval infestation measured after 72 hr | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies. |
| AID1112902 | Displacement of [3H]IMD from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1112899 | Insecticidal activity against Myzus persicae 4106A (green peach aphid) fed on compound treated chinese cabbage discs after 72 hr | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1082228 | Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 20 mg/l after 72 hr | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Synthesis, insecticidal activity, and molecular docking studies of nitenpyram analogues with a flexible ester arm anchored on tetrahydropyrimidine ring. |
| AID1092189 | Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 25 degC after 72 hr at 20 mg/L | 2012 | Journal of agricultural and food chemistry, Sep-26, Volume: 60, Issue:38 | Synthesis, insecticidal activity, crystal structure, and molecular docking studies of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring. |
| AID1111951 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as reduction in body weight at LC20 concentration measured after 48 hr by dipping method (Rvb = 0.36 +/- 0.0006 mg/aphid) | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1111948 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as longevity at LC20 concentration | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1082233 | Inhibition of Agaricus bisporus (mushroom) tyrosinase at IC50 concentration | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1111950 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as reduction in body weight at LC20 concentration measured after 72 hr by dipping method (Rvb = 0.40 +/- 0.0002 mg/aphid) | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1092185 | Insecticidal activity against Myzus persicae (green peach aphid) assessed as mortality at 25 degC after 72 hr at 4 mg/L | 2012 | Journal of agricultural and food chemistry, Sep-26, Volume: 60, Issue:38 | Synthesis, insecticidal activity, crystal structure, and molecular docking studies of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring. |
| AID1111954 | Resistance ratio, LC50 for Aphis gossypii RF45 (cotton aphid) to LC50 for Aphis gossypii SS | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1092184 | Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 25 degC after 72 hr | 2012 | Journal of agricultural and food chemistry, Sep-26, Volume: 60, Issue:38 | Synthesis, insecticidal activity, crystal structure, and molecular docking studies of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring. |
| AID1104204 | Insecticidal activity against adult female imidacloprid-susceptible Bemisia tabaci B-biotype NJ (sweet potato whitefly) in cotton leaf discs assessed as mortality treated for 10 secs prior to adult infestation measured after 72 hr by leaf-dip bioassay | 2009 | Pest management science, Nov, Volume: 65, Issue:11 | Cross-resistance, inheritance and biochemical mechanisms of imidacloprid resistance in B-biotype Bemisia tabaci. |
| AID1111953 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as reduction in body weight at LC20 concentration measured after 24 hr by dipping method (Rvb = 0.33 +/- 0.0004 mg/aphid) | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1112900 | Insecticidal activity against neonicotinoid-resistant Myzus persicae FRC-P (green peach aphid) fed on compound treated chinese cabbage discs after 72 hr | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1112898 | Resistance index, ratio of LC50 for neonicotinoid-resistant Myzus persicae FRC-P (green peach aphid) to LC50 for Myzus persicae 4106A | 2013 | Pest management science, May, Volume: 69, Issue:5 | Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid. |
| AID1091883 | In vivo insecticidal activity against fifth-instar larval stage of Nilaparvata lugens (brown planthopper) in second semester rice seedlings assessed as insect mortality at 10 mg/L treated for 5 secs before larval infestation measured after 72 hr | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11 | Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies. |
| AID1111183 | Insecticidal activity against B-biotype thiamethoxam-sensitive Bemisia tabaci (sweet potato whitefly) in cabbage leaf assessed as mortality after 48 hr by leaf disk assay | 2010 | Pest management science, Mar, Volume: 66, Issue:3 | Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae). |
| AID1111947 | Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as fecundity at LC20 concentration | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1082229 | Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 100 mg/l after 72 hr | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Synthesis, insecticidal activity, and molecular docking studies of nitenpyram analogues with a flexible ester arm anchored on tetrahydropyrimidine ring. |
| AID1111181 | Cross resistant, ratio of LC50 for B-biotype thiamethoxam-resistant Bemisia tabaci (sweet potato whitefly) to LC50 for B-biotype thiamethoxam-sensitive Bemisia tabaci (sweet potato whitefly) | 2010 | Pest management science, Mar, Volume: 66, Issue:3 | Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae). |
| AID1101023 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Myzus persicae (green peach aphid) whole body membrane after 90 min by filter binding assay | 2000 | Journal of neurochemistry, Sep, Volume: 75, Issue:3 | Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site. |
| AID318726 | Displacement of [3H]EPI from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay | 2007 | Proceedings of the National Academy of Sciences of the United States of America, May-22, Volume: 104, Issue:21 | Mapping the elusive neonicotinoid binding site. |
| AID1104200 | Resistance factor, ratio of LC50 for adult female Bemisia tabaci B-biotype NJ-Imi (sweet potato whitefly) (G30) to LC50 for adult female B-type Bemisia tabaci NJ | 2009 | Pest management science, Nov, Volume: 65, Issue:11 | Cross-resistance, inheritance and biochemical mechanisms of imidacloprid resistance in B-biotype Bemisia tabaci. |
| AID1111955 | Insecticidal activity against imidacloprid-resistant Aphis gossypii RF45 (cotton aphid) in cotton leaves assessed as mortality measured after 48 hr by dipping method | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1092188 | Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 25 degC after 72 hr at 4 mg/L | 2012 | Journal of agricultural and food chemistry, Sep-26, Volume: 60, Issue:38 | Synthesis, insecticidal activity, crystal structure, and molecular docking studies of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring. |
| AID1082241 | Phytotoxicity against Zea mays (maize) seedlings assessed as lesions at 50 to 100 ppm after 9 days | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1082237 | Inhibition of xanthine oxidase | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1092190 | Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 25 degC after 72 hr at 100 mg/L | 2012 | Journal of agricultural and food chemistry, Sep-26, Volume: 60, Issue:38 | Synthesis, insecticidal activity, crystal structure, and molecular docking studies of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring. |
| AID1111182 | Insecticidal activity against B-biotype thiamethoxam-resistant Bemisia tabaci (sweet potato whitefly) in cabbage leaf assessed as mortality after 48 hr by leaf disk assay | 2010 | Pest management science, Mar, Volume: 66, Issue:3 | Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae). |
| AID1111956 | Insecticidal activity against Aphis gossypii SS (cotton aphid) in cotton leaves assessed as mortality measured after 48 hr by dipping method | 2011 | Pest management science, Dec, Volume: 67, Issue:12 | Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii. |
| AID1082227 | Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality after 72 hr | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Synthesis, insecticidal activity, and molecular docking studies of nitenpyram analogues with a flexible ester arm anchored on tetrahydropyrimidine ring. |
| AID1101020 | Displacement of [3H]IMI from nicotinic acetylcholine receptor in Drosophila melanogaster head membrane after 90 min by filter binding assay | 2000 | Journal of neurochemistry, Sep, Volume: 75, Issue:3 | Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site. |
| AID1092186 | Insecticidal activity against Myzus persicae (green peach aphid) assessed as mortality at 25 degC after 72 hr at 20 mg/L | 2012 | Journal of agricultural and food chemistry, Sep-26, Volume: 60, Issue:38 | Synthesis, insecticidal activity, crystal structure, and molecular docking studies of nitenpyram analogues with an ω-hydroxyalkyl ester arm anchored on the tetrahydropyrimidine ring. |
| AID1082242 | Phytotoxicity against Gossypium hirsutum (cotton) seedlings assessed as lesions at 50 to 100 ppm after 9 days | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1082238 | Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition. |
| AID1082230 | Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 500 mg/l after 72 hr | 2011 | Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9 | Synthesis, insecticidal activity, and molecular docking studies of nitenpyram analogues with a flexible ester arm anchored on tetrahydropyrimidine ring. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (15.84) | 29.6817 |
| 2010's | 54 (53.47) | 24.3611 |
| 2020's | 31 (30.69) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 4 (3.92%) | 5.53% |
| Reviews | 1 (0.98%) | 6.00% |
| Case Studies | 1 (0.98%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 96 (94.12%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||