Nocturnal Wandering

A parasomnia characterized by a partial arousal that occurs during stage IV of non-REM sleep. Affected individuals exhibit semipurposeful behaviors such as ambulation and are difficult to fully awaken. Children are primarily affected, with a peak age range of 4-6 years.

Synonym
Sleep Walking
Somnambulism
Nocturnal Wandering
Sleep Walking Disorder
Sleepwalking

Excerpt	Reference
"Night-terrors and somnambulism are comparatively rare in adults and are most often associated with stage 4 sleep, especially delta activity."	( Cooper, AJ, 1987)
"Episodic nocturnal wandering is rare and thought to be an atypical form of nocturnal epilepsy which is responsive to anticonvulsant therapy."	( Chu, NS; Huang, YZ, 1998)
"Sleepwalking is a rare side effect of zolpidem."	( Dollear, M; Muthukrishnan, SR; Yang, W, 2005)
"Somnambulism is a common parasomnia that reflects an impairment in the normal mechanisms of arousal from sleep in which motor behaviors are activated without full consciousness."	( Hafeez, ZH; Kalinowski, CM, 2007)
"Sleepwalking is a frequently reported side effect of zolpidem which is a short-acting hypnotic drug potentiating activity of GABA(A) receptors."	( Juszczak, GR, 2011)
"Somnambulism or sleepwalking is a sleep disorder of arousal."	( Gill, JS; Jambunathan, ST; Koh, OH; Pillai, SK, 2011)
"Somnambulism (sleepwalking) is a disorder of arousal that falls under "parasomnia" group and is more common in children."	( Mathew, T; Nadig, R; Sarma, GR; Varghese, R, 2012)
"Somnambulism is a non-rapid eye movement sleep parasomnia with potential for significant injury as well as functional nighttime and daytime impairment."	( Boucetta, S; Desautels, A; Gibbs, SA; Montplaisir, J; Nigam, M; Zadra, A, 2019)

Excerpt	Reference
"Episodic nocturnal wandering is rare and thought to be an atypical form of nocturnal epilepsy which is responsive to anticonvulsant therapy."	( Chu, NS; Huang, YZ, 1998)
"A history of childhood somnambulism may increase the risk of developing sleepwalking behaviour while under psychotropic drugs treatment."	( Landry, P; Montplaisir, J; Nielsen, T; Warnes, H, 1999)
"Zolpidem has been associated with somnambulism, but our patient did not experience this when he was on zolpidem monotherapy."	( Bhatia, SC; Petty, F; Ramaswamy, S; Sattar, SP, 2003)
"Medications that trigger sleepwalking may inadvertently put the patient at risk of injury to themselves and/or others, and contribute to poor treatment adherence."	( Kohler, M; Stallman, HM; White, J, 2018)
"However, the optimal treatment of somnambulism has not been established."	( Boucetta, S; Desautels, A; Gibbs, SA; Montplaisir, J; Nigam, M; Zadra, A, 2019)
"This is a case report of a patient with sleepwalking likely caused by tapentadol ER secondary to higher than the recommended dose for the treatment of pain."	( Ko, EYJ; Tupper, MW, 2022)
"Recently, some cases of somnambulism or sleep-related eating disorder (SRED) have been reported in patients treated with these drugs."	( Ferreira, A; Gouverneur, A; Morival, C; Pageot, C; Pariente, A; Tournier, M, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	37 (25.69)	23.3326
1990's	22 (15.28)	12.5806
2000's	40 (27.78)	18.1394
2010's	40 (27.78)	28.8240
2020's	5 (3.47)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	1	0
bupropion	low	2	0
melatonin	medium	3	2
phenytoin	low	2	0
albuterol	low	1	0
alprazolam	medium	1	1
amitriptyline	low	3	0
benserazide	low	1	0
biperiden	medium	1	1
brotizolam	low	1	0
carbamazepine	low	3	0
cetirizine	low	1	0
chloral hydrate	low	4	0
chlordiazepoxide	low	1	0
chlorpheniramine	low	1	0
chlorpromazine	low	2	0
ciprofloxacin	low	1	0
citalopram	low	1	0
clonazepam	medium	13	1
amphetamine	low	3	0
diazepam	medium	7	1
diphenhydramine	low	1	0
valproic acid	low	3	0
fexofenadine	low	1	0
fluphenazine	low	1	0
fluoxetine	low	1	0
haloperidol	low	1	0
imipramine	low	10	0
loratadine	low	1	0
methylphenidate	low	2	0
metoprolol	low	1	0
apnea	low	3	0
oxazepam	low	1	0
perphenazine	low	2	0
phenobarbital	low	1	0
piracetam	low	1	0
pirenzepine	low	2	0
prazosin	low	1	0
propranolol	low	3	0
risperidone	medium	2	1
secobarbital	low	1	0
temazepam	low	1	0
terfenadine	low	1	0
thioridazine	low	4	0
thiothixene	low	1	0
triazolam	medium	5	1
zaleplon	low	4	0
zolpidem	low	24	0
zopiclone	low	3	0
levodopa	low	2	0
methaqualone	low	2	0
brompheniramine	low	1	0
quinoxalines	low	1	0
xanthenes	low	1	0
cyclohexanol	low	1	0
thiazoles	low	2	0
ephedrine	low	1	0
lithium carbonate	low	1	0
clopenthixol	low	1	0
2-piperidone	low	1	0
s,n,n'-tripropylthiocarbamate	low	1	0
pimozide	low	1	0
lisuride	low	1	0
bromocriptine	low	1	0
paroxetine	low	2	0
ziprasidone	low	1	0
venlafaxine hydrochloride	low	1	0
triazoles	low	1	0
fluorodeoxyglucose f18	low	1	0
nicotine	low	2	0
pramipexole	low	1	0
reboxetine	low	1	0
asenapine	low	1	0
varenicline	low	1	0
ramelteon	low	2	0
chlorprothixene	low	2	0
eszopiclone	low	2	0
benztropine	low	1	0
D-fructopyranose	low	3	0
lithium	medium	6	1
quinine	low	1	0
ethchlorvynol	low	1	0
levetiracetam	low	1	0
topiramate	low	3	0
cysteine	low	1	0
ergoline	low	1	0
tapentadol	low	1	0
technetium tc 99m exametazime	low	1	0
sodium oxybate	low	1	0
suvorexant	low	1	0
quetiapine fumarate	low	5	0
olanzapine	low	6	0
ego	low	3	0
technetium tc 99m bicisate	low	1	0

Protein Targets (847)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	0	1	1
glp-1 receptor, partial	9	0	0	9
thioredoxin reductase	25	0	0	25
GLS protein	19	0	0	19
regulator of G-protein signaling 4	16	0	0	16
estrogen-related nuclear receptor alpha	28	0	0	28
estrogen nuclear receptor alpha	41	0	0	41
NPYLR7B	0	0	1	1
arylsulfatase A	22	0	0	22
euchromatic histone-lysine N-methyltransferase 2	37	0	0	37
thyroid stimulating hormone receptor	13	0	0	13
flap endonuclease 1	6	0	0	6
peripheral myelin protein 22	17	0	0	17
ATP-binding cassette sub-family C member 3	0	38	0	38
Multidrug resistance-associated protein 4	0	38	0	38
Bile salt export pump	0	53	0	53
Beta-2 adrenergic receptor	0	9	4	13
Beta-1 adrenergic receptor	0	8	4	12
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-3 adrenergic receptor	0	5	3	8
Delta-type opioid receptor	0	5	1	6
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Beta-2 adrenergic receptor	0	4	4	9
Canalicular multispecific organic anion transporter 1	0	36	0	36
ATP-dependent phosphofructokinase	19	0	0	19
TDP1 protein	39	0	0	39
AR protein	37	0	0	37
glucocorticoid receptor [Homo sapiens]	28	0	0	28
pregnane X nuclear receptor	26	0	0	26
peroxisome proliferator activated receptor gamma	17	0	0	17
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	23	0	0	23
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
thyroid hormone receptor beta isoform 2	31	0	0	31
nuclear receptor ROR-gamma isoform 1	12	0	0	12
lamin isoform A-delta10	27	0	0	27
Gamma-aminobutyric acid receptor subunit pi	12	14	3	29
Bromodomain-containing protein 4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	12	6	18
Gamma-aminobutyric acid receptor subunit beta-1	12	14	3	29
Gamma-aminobutyric acid receptor subunit delta	12	14	3	29
Gamma-aminobutyric acid receptor subunit gamma-2	0	12	3	15
Gamma-aminobutyric acid receptor subunit gamma-2	12	14	3	29
Gamma-aminobutyric acid receptor subunit alpha-5	12	14	3	29
Gamma-aminobutyric acid receptor subunit alpha-3	12	14	3	29
Gamma-aminobutyric acid receptor subunit gamma-1	12	14	3	29
Gamma-aminobutyric acid receptor subunit alpha-2	12	14	3	29
Gamma-aminobutyric acid receptor subunit alpha-4	12	14	3	29
Gamma-aminobutyric acid receptor subunit gamma-3	12	14	3	29
Gamma-aminobutyric acid receptor subunit alpha-6	12	14	3	29
Cholecystokinin receptor type A	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	12	6	18
Gamma-aminobutyric acid receptor subunit alpha-3	0	12	4	16
Gamma-aminobutyric acid receptor subunit alpha-2	0	12	4	16
Gamma-aminobutyric acid receptor subunit beta-2	0	10	3	13
Gamma-aminobutyric acid receptor subunit alpha-1	12	14	3	29
Gamma-aminobutyric acid receptor subunit beta-3	12	14	3	29
Gamma-aminobutyric acid receptor subunit beta-2	12	14	3	29
Cholecystokinin receptor type A	0	4	0	4
GABA theta subunit	12	14	3	29
ATPase family AAA domain-containing protein 5	16	0	0	16
Ataxin-2	30	0	0	30
Gamma-aminobutyric acid receptor subunit epsilon	12	14	3	29
Luciferase	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	24	0	0	24
cytochrome P450 2D6	24	0	0	24
peroxisome proliferator-activated receptor delta	14	0	0	14
Snq2p	0	0	0	7
aryl hydrocarbon receptor	13	0	0	13
activating transcription factor 6	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	16	0	0	16
Cellular tumor antigen p53	25	0	0	25
Pleiotropic ABC efflux transporter of multiple drugs	0	7	0	14
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
USP1 protein, partial	14	0	0	14
NFKB1 protein, partial	7	0	0	7
cytochrome P450 2D6 isoform 1	16	0	0	16
D(1A) dopamine receptor	22	0	0	22
chromobox protein homolog 1	22	0	0	22
atrial natriuretic peptide receptor 2 precursor	11	0	0	11
serine/threonine-protein kinase mTOR isoform 1	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
muscarinic acetylcholine receptor M1	18	0	0	18
Solute carrier family 22 member 1	0	12	0	13
Polyunsaturated fatty acid lipoxygenase ALOX15B	10	0	0	10
Voltage-dependent L-type calcium channel subunit alpha-1F	0	13	0	13
5-hydroxytryptamine receptor 4	0	36	0	36
Albumin	0	0	9	9
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	27	0	27
Muscarinic acetylcholine receptor M2	0	27	2	29
Muscarinic acetylcholine receptor M4	0	26	1	27
Muscarinic acetylcholine receptor M1	0	11	0	11
Muscarinic acetylcholine receptor M3	0	10	0	10
Muscarinic acetylcholine receptor M4	0	12	0	12
5-hydroxytryptamine receptor 2C	0	24	1	25
Muscarinic acetylcholine receptor M5	0	12	0	12
Muscarinic acetylcholine receptor M5	0	26	0	26
Alpha-2A adrenergic receptor	0	34	2	38
Muscarinic acetylcholine receptor M2	0	11	0	11
Muscarinic acetylcholine receptor M1	0	31	4	36
Angiotensin-converting enzyme	0	29	0	29
D(2) dopamine receptor	0	39	8	54
5-hydroxytryptamine receptor 2A	0	24	1	25
Alpha-2B adrenergic receptor	0	33	1	36
Alpha-2C adrenergic receptor	0	36	2	40
5-hydroxytryptamine receptor 1A	0	37	4	42
Muscarinic acetylcholine receptor M3	0	32	2	34
D(1A) dopamine receptor	0	29	2	34
D(1B) dopamine receptor	0	9	0	12
UDP-glucuronosyltransferase 1A4	0	1	0	7
Sodium-dependent noradrenaline transporter	0	36	2	38
Histamine H2 receptor	0	21	2	23
Alpha-1D adrenergic receptor	0	35	2	40
5-hydroxytryptamine receptor 2A	0	43	4	50
5-hydroxytryptamine receptor 2C	0	42	4	46
5-hydroxytryptamine receptor 1B	0	26	1	27
5-hydroxytryptamine receptor 1D	0	10	1	11
5-hydroxytryptamine receptor 1F	0	10	1	11
5-hydroxytryptamine receptor 2B	0	21	2	23
5-hydroxytryptamine receptor 6	0	3	1	4
Histamine H1 receptor	0	8	0	8
Sodium-dependent serotonin transporter	0	35	4	39
5-hydroxytryptamine receptor 7	0	11	1	12
5-hydroxytryptamine receptor 5A	0	3	1	4
5-hydroxytryptamine receptor 5B	0	3	1	4
Histamine H1 receptor	0	46	5	54
D(3) dopamine receptor	0	34	4	44
Sodium channel protein type 1 subunit alpha	0	7	0	7
Sodium channel protein type 4 subunit alpha	0	7	0	9
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	5	1	6
5-hydroxytryptamine receptor 2B	0	42	2	44
Alpha-1A adrenergic receptor	0	29	5	34
Histamine H2 receptor	15	3	0	22
D(1A) dopamine receptor	12	1	0	13
5-hydroxytryptamine receptor 6	0	35	1	38
5-hydroxytryptamine receptor 7	0	10	0	10
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	13	0	13
Sodium-dependent dopamine transporter	0	24	2	26
Potassium voltage-gated channel subfamily H member 2	0	51	0	52
Voltage-dependent L-type calcium channel subunit alpha-1S	0	13	0	13
Voltage-dependent L-type calcium channel subunit alpha-1C	0	14	0	14
Sodium channel protein type 5 subunit alpha	0	11	0	11
Sodium channel protein type 9 subunit alpha	0	8	0	8
Sigma non-opioid intracellular receptor 1	0	5	1	6
5-hydroxytryptamine receptor 4	0	3	1	4
Nuclear receptor subfamily 3 group C member 3	0	27	0	27
Sodium channel protein type 2 subunit alpha	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	24	0	24
5-hydroxytryptamine receptor 3B	0	5	1	6
Sodium channel protein type 3 subunit alpha	0	7	0	7
Sodium channel protein type 11 subunit alpha	0	5	0	5
Sodium channel protein type 8 subunit alpha	0	5	0	5
Histamine H3 receptor	0	9	0	9
Sodium channel protein type 10 subunit alpha	0	5	0	5
Solute carrier family 22 member 3	0	1	0	1
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	4	1	5
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	2	0	2
Sodium-dependent dopamine transporter	0	22	1	23
Sigma non-opioid intracellular receptor 1	0	9	0	9
ATAD5 protein, partial	14	0	0	14
Microtubule-associated protein tau	16	0	0	16
Bloom syndrome protein isoform 1	10	0	0	10
neuropeptide S receptor isoform A	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
5-hydroxytryptamine receptor 3E	0	6	0	6
acetylcholinesterase	15	0	0	15
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
RAR-related orphan receptor gamma	19	0	0	19
SMAD family member 2	4	0	0	4
Fumarate hydratase	12	0	0	12
PPM1D protein	3	0	0	3
SMAD family member 3	4	0	0	4
GLI family zinc finger 3	30	0	0	30
estrogen receptor 2 (ER beta)	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	27	0	0	27
progesterone receptor	15	0	0	15
EWS/FLI fusion protein	19	0	0	19
retinoic acid nuclear receptor alpha variant 1	24	0	0	24
retinoid X nuclear receptor alpha	17	0	0	17
farnesoid X nuclear receptor	15	0	0	15
G	12	0	0	12
polyprotein	12	0	0	12
67.9K protein	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
lysosomal alpha-glucosidase preproprotein	4	0	0	4
mu-type opioid receptor isoform MOR-1	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	21	0	0	21
transcriptional regulator ERG isoform 3	4	0	0	4
heat shock protein beta-1	7	0	0	7
geminin	28	0	0	28
histone acetyltransferase KAT2A isoform 1	9	0	0	9
5-hydroxytryptamine receptor 2A	0	0	1	1
Solute carrier family 22 member 2	0	7	0	8
5-hydroxytryptamine receptor 3A	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
5-hydroxytryptamine receptor 3B	0	6	0	6
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
ATP-dependent translocase ABCB1	0	17	0	27
Cytochrome P450 3A4	0	14	0	17
5-hydroxytryptamine receptor 1A	0	20	10	30
Neuronal acetylcholine receptor subunit alpha-4	2	6	3	12
Neuronal acetylcholine receptor subunit beta-2	2	6	3	12
Alpha-1B adrenergic receptor	0	27	5	32
D	0	20	0	20
Glutamate receptor 2	12	1	0	13
D(4) dopamine receptor	0	19	3	27
Alpha-1D adrenergic receptor	0	25	5	30
D(4) dopamine receptor	0	13	0	13
Histamine H1 receptor	0	6	0	7
5-hydroxytryptamine receptor 7	0	16	1	17
Alpha-1A adrenergic receptor	0	17	3	25
Alpha-1B adrenergic receptor	0	11	2	16
5-hydroxytryptamine receptor 3A	0	9	0	9
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	5	0	5
Spike glycoprotein	23	2	3	28
D(2) dopamine receptor	0	28	3	32
Inositol monophosphatase 1	10	0	0	10
5-hydroxytryptamine receptor 3D	0	6	0	6
Multidrug and toxin extrusion protein 2	0	6	0	6
5-hydroxytryptamine receptor 3C	0	6	0	6
Inositol hexakisphosphate kinase 1	12	0	0	12
Multidrug and toxin extrusion protein 1	0	7	0	7
cytochrome P450 2C9, partial	12	0	0	12
vitamin D3 receptor isoform VDRA	9	0	0	9
M-phase phosphoprotein 8	13	0	0	13
Zinc finger protein mex-5	0	0	1	1
POsterior Segregation	0	0	1	1
Genome polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	4	3	7
Hexokinase-2	0	1	0	1
Spike glycoprotein	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Transmembrane protease serine 2	0	2	3	5
Procathepsin L	0	2	3	5
Replicase polyprotein 1a	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Replicase polyprotein 1ab	0	2	3	5
Sodium-dependent serotonin transporter	0	12	1	13
Angiotensin-converting enzyme 2	0	2	3	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Genome polyprotein	0	1	1	2
dopamine D1 receptor	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
ATP-dependent translocase ABCB1	0	3	0	3
Androgen receptor	0	3	0	3
D(3) dopamine receptor	0	16	1	17
Alpha-2B adrenergic receptor	0	19	4	23
ATP-dependent translocase ABCB1	0	3	0	3
Alpha-2C adrenergic receptor	0	19	4	23
Alpha-2A adrenergic receptor	0	19	4	23
D(1B) dopamine receptor	0	11	0	11
Alpha-synuclein	0	1	0	1
Platelet-activating factor receptor	0	2	0	2
Acetylcholine receptor subunit alpha	0	5	2	7
Acetylcholine receptor subunit gamma	0	5	2	7
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	5	2	7
UDP-glucuronosyltransferase 2B7	0	3	0	6
Neuronal acetylcholine receptor subunit beta-2	0	5	2	8
UDP-glucuronosyltransferase 1-6	0	1	0	2
Cytochrome P450 2B6	0	0	1	3
UDP-glucuronosyltransferase 1A1	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	5	2	8
Neuronal acetylcholine receptor subunit alpha-3	0	5	2	7
Cytochrome P450 2C19	0	7	0	9
UDP-glucuronosyltransferase 2B10	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	4	2	6
Neuronal acetylcholine receptor subunit alpha-4	0	5	2	8
Acetylcholine receptor subunit delta	0	5	2	7
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
cytochrome P450 2C9 precursor	9	0	0	9
cytochrome P450 3A4 isoform 1	12	0	0	12
Bile salt export pump	0	7	0	7
Beta-2 adrenergic receptor	0	7	0	8
Angiotensin-converting enzyme	0	2	0	2
Beta-1 adrenergic receptor	0	7	2	10
D(2) dopamine receptor	0	6	0	6
Beta-3 adrenergic receptor	0	5	0	5
Alpha-2A adrenergic receptor	0	2	0	2
D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D	0	6	0	6
Lysosomal alpha-glucosidase	0	1	0	1
Chain A, Beta-lactamase	7	0	0	7
thyroid stimulating hormone receptor	10	0	0	10
IDH1	9	0	0	9
thyroid hormone receptor beta isoform a	5	0	0	5
mitogen-activated protein kinase 1	11	0	0	11
Vpr	2	0	0	2
Major prion protein	0	0	4	4
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	13	0	14
Cytochrome P450 2J2	0	12	0	13
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Histamine H4 receptor	0	7	2	9
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	0	4
Translocator protein	0	4	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	10	2	12
Gastrin/cholecystokinin type B receptor	0	3	0	3
atrial natriuretic peptide receptor 1 precursor	6	0	0	6
MBT domain-containing protein 1	0	1	0	1
Solute carrier family 22 member 1	0	6	0	8
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Solute carrier family 22 member 2	0	6	0	7
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Proteasome subunit beta type-11	0	0	0	1
phosphopantetheinyl transferase	8	0	0	8
Thrombopoietin	8	0	0	8
Smad3	6	0	0	6
caspase 7, apoptosis-related cysteine protease	10	0	0	10
NADPH oxidase 1	0	3	0	3
caspase-3	10	0	0	10
Adenylate cyclase type 1	0	4	0	4
Histone H2A.x	7	0	0	7
Caspase-7	7	0	0	7
cellular tumor antigen p53 isoform a	6	0	0	6
caspase-3	7	0	0	7
histone deacetylase 9 isoform 3	3	0	0	3
ras-related protein Rab-9A	11	0	0	11
DNA polymerase kappa isoform 1	4	0	0	4
survival motor neuron protein isoform d	8	0	0	8
lethal factor (plasmid)	8	0	0	8
Proteasome subunit alpha type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Potassium channel subfamily K member 2	0	6	2	8
Epidermal growth factor receptor	0	5	0	5
Albumin	0	2	6	9
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	0	1	1
Integrin beta-3	6	0	0	6
Cytochrome P450 1A2	0	5	1	7
Tyrosine-protein kinase Fyn	0	5	0	5
Integrin alpha-IIb	6	0	0	6
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Cytochrome P450 2D6	0	14	1	16
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Sphingomyelin phosphodiesterase	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	6	0	6
Adenylate cyclase type 3	0	4	0	4
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	4	0	4
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	4	0	4
Mu-type opioid receptor	0	9	3	12
Glutamate receptor ionotropic, NMDA 1	0	3	0	4
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	7	1	8
Kappa-type opioid receptor	0	8	1	9
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	2	3
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	5
Glutamate receptor ionotropic, NMDA 2C	0	3	0	4
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	3	0	5
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	0	4
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	0	4
Proteasome subunit beta type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	4
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
DNA polymerase iota isoform a (long)	7	0	0	7
Guanine nucleotide-binding protein G	3	0	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Chain A, Cruzipain	2	0	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	3	0	4
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	3	0	4
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	8	0	0	8
Sodium-dependent noradrenaline transporter	0	4	0	4
Tryptophan 5-hydroxylase 1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
Acetylcholinesterase	0	4	0	4
Aromatase	0	1	0	1
Sigma intracellular receptor 2	0	4	0	4
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	4	0	4
Transporter	0	15	1	17
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	7	0	7
Gamma-aminobutyric acid receptor subunit delta	0	7	0	7
Gamma-aminobutyric acid receptor subunit beta-1	0	8	0	8
Translocator protein	0	2	0	2
Translocator protein	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	9	0	9
Gamma-aminobutyric acid receptor subunit epsilon	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	10	0	10
Gamma-aminobutyric acid receptor subunit gamma-1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	7	1	8
Gamma-aminobutyric acid receptor subunit theta	0	7	0	7
Beta-1 adrenergic receptor	0	2	2	5
glucocerebrosidase	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
peripheral myelin protein 22 isoform 1	9	0	0	9
cytochrome P450 2C19 precursor	7	0	0	7
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	3	0	0	3
Endothelin receptor type B	0	2	0	2
5-hydroxytryptamine receptor 3A	0	4	0	4
Endothelin receptor type B	0	2	0	2
Adenosine receptor A1	0	3	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 5A	0	2	0	2
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	6	0	6
5-hydroxytryptamine receptor 1A	0	2	0	2
Gamma-aminobutyric acid	0	2	0	2
Fatty acid-binding protein, liver	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	6	3	10
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
huntingtin isoform 2	6	0	0	6
Histamine N-methyltransferase	0	0	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H3 receptor	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Cytochrome P450 2C8	0	3	0	3
Dipeptidyl peptidase 4	0	2	0	2
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	7	0	0	7
Adenosine receptor A3	0	3	1	4
Disintegrin and metalloproteinase domain-containing protein 17	6	0	0	6
POU domain, class 2, transcription factor 1	0	0	0	1
Nischarin	0	1	0	1
15-lipoxygenase, partial	4	0	0	4
nonstructural protein 1	2	0	0	2
Cocaine esterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
UDP-glucuronosyltransferase 1A9	0	1	0	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	1	0	1
Mu-type opioid receptor	0	5	0	5
Kappa-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
TAR DNA-binding protein 43	4	0	0	4
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Envelope glycoprotein	0	0	2	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Synaptic vesicle glycoprotein 2A	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
apical membrane antigen 1, AMA1	3	0	0	3
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
Polyphenol oxidase 2	0	1	0	3
Carbonic anhydrase 12	0	2	0	4
Carbonic anhydrase 1	0	4	0	6
Carbonic anhydrase 2	0	4	1	7
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Carbonic anhydrase 3	0	2	0	3
Tyrosinase	0	1	0	1
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 6	0	2	0	4
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	1	5
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 7	0	2	0	4
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	2	0	4
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	2	0	3
Carbonic anhydrase 13	0	2	0	4
Carbonic anhydrase 14	0	2	0	4
Carbonic anhydrase 5B, mitochondrial	0	2	0	4
phosphoglycerate kinase	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
alpha-galactosidase	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Bile acid receptor	0	1	0	1
Sodium-dependent neutral amino acid transporter B(0)AT2	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
interleukin 8	2	0	0	2
ClpP	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	2	0	2
Cholinesterase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	0	3
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	3	1	4
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	3	1	4
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear receptor ROR-gamma	3	0	0	3
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Beta-1 adrenergic receptor	0	2	0	2
Endothelin-1 receptor	0	2	1	3
5-hydroxytryptamine receptor 1D	0	3	0	3
Type-2 angiotensin II receptor	0	3	0	3
Angiotensin-converting enzyme	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	4	3	8
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	3	2	6
Neuronal acetylcholine receptor subunit beta-3	0	2	3	6
Neuronal acetylcholine receptor subunit beta-4	0	4	3	8
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	2	2
Muscarinic acetylcholine receptor M4	0	3	0	3
Delta-type opioid receptor	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	3	6
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Mu-type opioid receptor	0	3	0	3
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
endonuclease IV	4	0	0	4
ubiquitin-conjugating enzyme E2 N	0	2	0	2
protein AF-9 isoform a	0	0	0	1
bcl-2-related protein A1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Aldehyde oxidase 1	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Dihydrofolate reductase	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
pregnane X receptor	2	0	0	2
GALC protein	3	0	0	3
DNA polymerase III, partial	1	0	0	1
XBP1	0	2	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA damage-inducible transcript 3 protein	0	2	0	2
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
WD repeat-containing protein 48	0	1	0	1
Hsf1 protein	0	0	1	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
5-hydroxytryptamine receptor 1B	0	4	1	5
5-hydroxytryptamine receptor 1E	0	1	0	1
interferon gamma precursor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Beta-casein	0	1	0	1
Interstitial collagenase	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-mannosidase 2C1	0	0	1	1
Bromodomain-containing protein 2	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Free fatty acid receptor 3	0	0	1	1
Orexin receptor type 1	0	2	0	2
Orexin receptor type 2	0	2	0	2
Orexin receptor type 1	0	1	0	1
Orexin receptor type 2	0	1	0	1
Substance-K receptor	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Parkin	2	0	0	2
Transcriptional activator protein LuxR	0	1	0	1
C-C chemokine receptor type 5	0	2	0	2
Cathepsin D	0	1	0	1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Histone deacetylase 3	0	2	0	2
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Treatment

Research

Studies (144)

Protein Targets (847)

Nocturnal Wandering

Synonyms(5)

Research Excerpts

Overview

Treatment

Research

Studies (144)

Drugs Studied (102)

Protein Targets (847)