triazoles has been researched along with fluorobenzenes in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 18 (47.37) | 29.6817 |
| 2010's | 17 (44.74) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Das, PR; DiBenedetto, DJ; Gala, D; Kugelman, M; Puar, MS | 1 |
| Crews, T; Davis, PP; Edom, RW; Gabriel, L; Wang, K | 1 |
| Atack, JR; Bristow, L; Brown, N; Carling, RW; Castro, JL; Cook, G; Dawson, GR; Farrar, S; Ferris, P; Garrett, L; Howell, O; Macaulay, A; Marshall, G; McKernan, RM; Moore, KW; Myers, J; Ragan, CI; Reynolds, DS; Rosahl, TW; Street, LJ; Sur, C; Wafford, KA; Whiting, PJ | 1 |
| Dawson, GR; McKernan, RM; Reynolds, DS | 1 |
| Atack, JR; Dawson, GR; Leslie, JC; McCabe, C; Reynolds, DS; Shaw, D; Street, LJ; Wafford, KA | 1 |
| Basile, AS; Lippa, AS; Skolnick, P | 1 |
| Atack, JR; Scott-Stevens, P; Sohal, B; Worboys, P | 1 |
| Kiss, A; Mikkelsen, JD; Mirza, N; Søderman, A | 1 |
| Mathiasen, L; Mirza, NR | 1 |
| France, CP; McMahon, LR | 1 |
| Mathiasen, LS; Mirza, NR; Rodgers, RJ | 3 |
| Groenink, L; Olivier, B; Oosting, R; Toth, M; Van Bogaert, M; van Oorschot, R | 1 |
| Erdi, P; Hajós, M; Hoffmann, WE; Kiss, T; Orbán, G; Ujfalussy, B | 1 |
| Ahmadi, S; Brockhaus, J; Brune, K; Fritschy, JM; Hess, A; Hösl, K; Knabl, J; Möhler, H; Reinold, H; Rudolph, U; Sergejeva, M; Witschi, R; Zeilhofer, HU; Zeilhofer, UB | 1 |
| Bostwick, R; Chen, T; Huston, J; Knappenberger, K; Liu, J; Norris, T; Wood, M | 1 |
| Bundzikova, J; Hansen, HH; Kiss, A; Larsen, MH; Mikkelsen, JD | 1 |
| Allen, MS; Brian Nofsinger, J; Hopkins, SC; Koch, P; Varney, MA | 1 |
| Clifton, PG; Dixon, CI; Morris, HV; Nilsson, S; Stephens, DN | 1 |
| Atack, JR; Cook, JM; Dawson, GR; Licata, SC; Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Van Linn, ML | 1 |
| Atack, JR | 2 |
| Bunck, M; Gaburro, S; Hauschild, M; Landgraf, R; Sartori, SB; Singewald, N | 1 |
| Dunn, PJ | 1 |
| Gong, Z; Xiong, YC | 1 |
| Bi, YA; El-Kattan, AF; Fenner, KS; Iseki, K; Kimoto, E; Lai, Y; Linder, C; Walsky, R; Whalen, KM; Xiao, Y; Yang, YS; Zhang, H | 1 |
| Arafat, T; Idkaidek, N | 1 |
| Anderson, R; Carlson, G; Gandal, MJ; Gur, RE; Jonak, G; Klook, K; Leitman, V; Liang, Y; Ortinski, PI; Pierce, RC; Siegel, SJ; Sisti, J; Thieu, T | 1 |
| Bölcskei, K; Danysz, W; Dekundy, A; Dézsi, L; Gravius, A; Gyertyán, I; Hofmann, M; Horváth, C; Kordás, KS; Parsons, CG; Sághy, K; Wittko-Schneider, IM | 1 |
| Morales, M; Spear, LP; Varlinskaya, EI | 1 |
| Catterall, WA; Han, S; Jones, CJ; Scheuer, T; Tai, C | 1 |
| Chaki, S; Hiyoshi, T; Kambe, D; Karasawa, J | 1 |
| Barragán-Iglesias, P; Bravo-Hernández, M; Calcutt, NA; Corleto, JA; Delgado-Lezama, R; Felix, R; González-Ramírez, R; Granados-Soto, V; Marsala, M; Pineda-Farias, JB | 1 |
| Bao, S; Lian, QQ; Liu, H; Lv, K; Su, Y; Wang, B; Wang, H; Wang, S; Zhou, WH | 1 |
| Baird, JP; Holstein, SE; Nelson, TS; Pittman, DW | 1 |
| Freeman, KB; Huskinson, SL; Rowlett, JK | 1 |
| Bachand, K; Boudreau, D; De Koninck, Y; Doyon, N; Ferrini, F; Gagnon, M; Girard, AA; Godin, AG; Kianicka, I; Labrecque, S; Lorenzo, LE; Plasencia-Fernandez, I; Ribeiro-da-Silva, A | 1 |
4 review(s) available for triazoles and fluorobenzenes
| Article | Year |
|---|---|
Anxioselective anxiolytics: can less be more?
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepinones; Carbolines; Clinical Trials as Topic; Fluorobenzenes; GABA-A Receptor Agonists; Humans; Indoles; Pyrroles; Quinolones; Triazoles | 2004 |
GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
Topics: Animals; Benzodiazepines; Cognition; Diazepam; Female; Fluorobenzenes; GABA-A Receptor Agonists; Hippocampus; Humans; Isoxazoles; Male; Maze Learning; Memory; Mice; Nootropic Agents; Protein Isoforms; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Substrate Specificity; Triazines; Triazoles | 2011 |
GABAA receptor subtype-selective modulators. I. α2/α3-selective agonists as non-sedating anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Benzimidazoles; Benzodiazepines; Diazepam; Dogs; Fluorobenzenes; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; Male; Mice; Mice, Transgenic; Protein Isoforms; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Structure-Activity Relationship; Substrate Specificity; Triazoles | 2011 |
The importance of green chemistry in process research and development.
Topics: Biocatalysis; Fluorobenzenes; gamma-Aminobutyric Acid; Green Chemistry Technology; Lipase; Pharmaceutical Preparations; Pregabalin; Pyrazines; Pyrimidines; Rosuvastatin Calcium; Sitagliptin Phosphate; Solvents; Sulfonamides; Transaminases; Triazoles | 2012 |
34 other study(ies) available for triazoles and fluorobenzenes
| Article | Year |
|---|---|
Decomposition of alpha-hydroxyaryl ketones and characterization of some unusual products.
Topics: Antifungal Agents; Benzene; Chromatography, Thin Layer; Drug Stability; Fluorobenzenes; Ketones; Oxidation-Reduction; Triazoles | 1992 |
An electron-capture dienophile derivatization agent for increasing sensitivity: determination of a vitamin D analog (Ro 24-2090) in plasma samples with liquid chromatography/mass spectrometry.
Topics: Animals; Cholecalciferol; Chromatography, High Pressure Liquid; Cricetinae; Dogs; Fluorobenzenes; Haplorhini; Humans; Mass Spectrometry; Mice; Rabbits; Rats; Swine; Triazoles | 1996 |
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
Topics: Allosteric Site; Animals; Anti-Anxiety Agents; Anticonvulsants; Azides; Benzodiazepines; Binding, Competitive; Brain; Cell Line; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Fluorobenzenes; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Motor Activity; Patch-Clamp Techniques; Receptors, GABA-A; Reflex, Startle; Triazoles | 2000 |
Anxiolytic-like action of diazepam: which GABA(A) receptor subtype is involved?
Topics: Animals; Anti-Anxiety Agents; Diazepam; Fluorobenzenes; Locomotion; Mice; Point Mutation; Rats; Receptors, GABA-A; Triazoles | 2001 |
Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour.
Topics: Animals; Conditioning, Operant; Extinction, Psychological; Fluorobenzenes; GABA Agents; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Male; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Triazoles | 2004 |
Rodent pharmacokinetics and receptor occupancy of the GABAA receptor subtype selective benzodiazepine site ligand L-838417.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Brain; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flumazenil; Fluorobenzenes; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Transgenic; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Rodentia; Species Specificity; Triazoles; Tritium | 2005 |
Effects of benzodiazepines receptor agonists on the hypothalamic-pituitary-adrenocortical axis.
Topics: Adrenocorticotropic Hormone; Animals; Azabicyclo Compounds; Carbolines; Corticosterone; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fluorobenzenes; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred Strains; Models, Biological; Paraventricular Hypothalamic Nucleus; Piperazines; Pituitary-Adrenal System; Proto-Oncogene Proteins c-fos; Pyridines; Radioimmunoassay; Receptors, GABA-A; Triazoles; Zolpidem | 2005 |
A comparison of chlordiazepoxide, bretazenil, L838,417 and zolpidem in a validated mouse Vogel conflict test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepinones; Chlordiazepoxide; Conflict, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drinking Behavior; Drug Interactions; Electroshock; Fluorobenzenes; GABA Agents; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pyridines; Reaction Time; Reproducibility of Results; Time Factors; Triazoles; Water Deprivation; Zolpidem | 2005 |
Differential behavioral effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Fluorobenzenes; GABA Modulators; Macaca mulatta; Midazolam; Pregnanediones; Receptors, GABA-A; Triazoles | 2006 |
Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination.
Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Cues; Discrimination Learning; Fluorobenzenes; GABA Modulators; Generalization, Psychological; Male; Piperazines; Protein Subunits; Pyridazines; Pyridines; Rats; Receptors, GABA-A; Triazoles; Zolpidem | 2006 |
Effects of genetic background and null mutation of 5-HT1A receptors on basal and stress-induced body temperature: modulation by serotonergic and GABAA-ergic drugs.
Topics: Animals; Body Temperature; Body Temperature Regulation; Buspirone; Diazepam; Fever; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Modulators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Stress, Psychological; Triazoles; Zolpidem | 2006 |
Pharmacological and computational analysis of alpha-subunit preferential GABA(A) positive allosteric modulators on the rat septo-hippocampal activity.
Topics: Action Potentials; Animals; Electroencephalography; Fluorobenzenes; GABA Agonists; GABA Antagonists; Hippocampus; Male; Models, Neurological; Neural Networks, Computer; Neural Pathways; Neurons; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Septum of Brain; Triazoles; Zolpidem | 2007 |
Comparative effects of nonselective and subtype-selective gamma-aminobutyric acidA receptor positive modulators in the rat-conditioned emotional response test.
Topics: Amygdala; Animals; Conditioning, Operant; Emotions; Fluorobenzenes; Functional Laterality; GABA Agents; GABA Modulators; Ligands; Male; Microinjections; Midazolam; Rats; Receptors, GABA-A; Structure-Activity Relationship; Triazoles | 2007 |
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenzenes; Formaldehyde; Ganglia, Spinal; Hot Temperature; Inflammation; Male; Mice; Neurons; Organ Specificity; Pain; Protein Isoforms; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Triazoles | 2008 |
Strain- and model-dependent effects of chlordiazepoxide, L-838,417 and zolpidem on anxiety-like behaviours in laboratory mice.
Topics: Animals; Anxiety; Behavior, Animal; Chlordiazepoxide; Conflict, Psychological; Darkness; Fluorobenzenes; GABA Modulators; Hypnotics and Sedatives; Light; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Models, Psychological; Pyridines; Species Specificity; Triazoles; Zolpidem | 2008 |
A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.
Topics: Carbolines; Cell Culture Techniques; Cell Line; Cell Membrane; Cryopreservation; Diazepam; DNA; Dose-Response Relationship, Drug; Drug Discovery; Flumazenil; Flunitrazepam; Fluorescent Dyes; Fluorobenzenes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Receptors, GABA-A; Reproducibility of Results; Spectrometry, Fluorescence; Transfection; Triazoles; Tritium | 2008 |
GABA regulates the rat hypothalamic-pituitary-adrenocortical axis via different GABA-A receptor alpha-subtypes.
Topics: Animals; Brain; Corticotropin-Releasing Hormone; Diazepam; Fluorobenzenes; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamo-Hypophyseal System; Male; Neural Pathways; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Protein Subunits; Proto-Oncogene Proteins c-fos; Pyridines; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Triazoles; Zolpidem | 2008 |
In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry.
Topics: Algorithms; Animals; Azabicyclo Compounds; Binding Sites; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; In Vitro Techniques; Indicators and Reagents; Ligands; Male; Mice; Models, Statistical; Piperazines; Pyridines; Receptors, GABA-A; Stereoisomerism; Tandem Mass Spectrometry; Triazoles; Zolpidem | 2009 |
Alpha1- and alpha2-containing GABAA receptor modulation is not necessary for benzodiazepine-induced hyperphagia.
Topics: Analysis of Variance; Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Energy Intake; Female; Fluorobenzenes; GABA Modulators; GABA-A Receptor Agonists; Hyperphagia; Male; Mice; Mice, Knockout; Midazolam; Random Allocation; Receptors, GABA-A; Triazoles | 2009 |
Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes.
Topics: Animals; Barbiturates; Carbolines; Catheterization; Central Nervous System Depressants; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Fluorobenzenes; GABA Agonists; GABA Antagonists; GABA Modulators; Neuropsychological Tests; Pyridines; Receptors, GABA-A; Saimiri; Triazoles; Zolpidem | 2010 |
Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Corticosterone; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Expressed Emotion; Fear; Fluorobenzenes; Male; Mice; Neurokinin-1 Receptor Antagonists; Phobic Disorders; Physical Conditioning, Animal; Piperidines; Psychopathology; Triazoles; Up-Regulation | 2011 |
[Effect of L-838,417 on pain behavior in a rat model of trigeminal neuralgia].
Topics: Animals; Fluorobenzenes; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Triazoles; Trigeminal Neuralgia | 2011 |
Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes.
Topics: Anti-Anxiety Agents; Anticholesteremic Agents; Atorvastatin; Bile; Biological Transport; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluorobenzenes; Hepatocytes; Heptanoic Acids; Humans; Isoenzymes; Midazolam; Models, Biological; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides; Time Factors; Triazoles | 2012 |
Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system.
Topics: Acetates; Anthraquinones; Azithromycin; Benzhydryl Compounds; Cinacalcet; Cloxacillin; Cresols; Cyclopropanes; Female; Fluorobenzenes; Humans; Hydrochlorothiazide; Losartan; Male; Metformin; Naphthalenes; Phenylpropanolamine; Piroxicam; Pyrazines; Pyrimidines; Quinolines; Rosuvastatin Calcium; Saliva; Sitagliptin Phosphate; Sulfides; Sulfonamides; Tamsulosin; Tolterodine Tartrate; Triazoles | 2012 |
GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.
Topics: Animals; Autistic Disorder; Baclofen; Disease Models, Animal; Evoked Potentials, Auditory; Exploratory Behavior; Fluorobenzenes; GABA-B Receptor Agonists; In Situ Hybridization; Intellectual Disability; Interneurons; Male; Mice; Mice, Transgenic; Parvalbumins; Phenotype; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Risperidone; Schizophrenia; Social Behavior; Synaptic Potentials; Triazoles | 2012 |
Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function.
Topics: Allosteric Regulation; Analgesics; Animals; Anxiety; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Fear; Fluorobenzenes; GABA-A Receptor Agonists; Male; Maze Learning; Memory Disorders; Motor Activity; Pain; Rats; Rats, Wistar; Receptors, GABA-A; Triazoles | 2012 |
Anxiolytic effects of the GABA(A) receptor partial agonist, L-838,417: impact of age, test context familiarity, and stress.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Female; Fluorobenzenes; GABA Agonists; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 2013 |
Enhancement of inhibitory neurotransmission by GABAA receptors having α2,3-subunits ameliorates behavioral deficits in a mouse model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Benzodiazepines; Brain; Disease Models, Animal; Fluorobenzenes; Interpersonal Relations; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Protein Subunits; Pyridines; Receptors, GABA-A; Social Behavior; Synaptic Transmission; Triazoles; Zolpidem | 2014 |
Involvement of glutamatergic and GABAergic transmission in MK-801-increased gamma band oscillation power in rat cortical electroencephalograms.
Topics: Amino Acids; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Excitatory Amino Acid Antagonists; Fluorobenzenes; GABA Agents; Gamma Rhythm; gamma-Aminobutyric Acid; Glutamic Acid; Haloperidol; Male; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Riluzole; Triazoles | 2014 |
The α5 subunit containing GABAA receptors contribute to chronic pain.
Topics: Animals; Chronic Pain; Female; Fluorobenzenes; Hyperalgesia; Imidazoles; Injections, Spinal; Pain Measurement; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Triazoles | 2016 |
Contribution of the α5 GABAA receptor to the discriminative stimulus effects of propofol in rat.
Topics: Animals; Carbolines; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluorobenzenes; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Imidazoles; Indoles; Male; Propofol; Pyridazines; Pyrroles; Random Allocation; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 2018 |
Selective stimulation of central GABA
Topics: Animals; Behavior, Animal; Eating; Fluorobenzenes; GABA-A Receptor Agonists; Injections, Intraventricular; Male; Motivation; Rats; Rats, Sprague-Dawley; Sucrose; Triazoles | 2019 |
Self-administration of benzodiazepine and cocaine combinations by male and female rhesus monkeys in a choice procedure: role of α1 subunit-containing GABA
Topics: Animals; Benzodiazepines; Choice Behavior; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Female; Fluorobenzenes; Macaca mulatta; Male; Receptors, GABA-A; Self Administration; Triazoles | 2019 |
Enhancing neuronal chloride extrusion rescues α2/α3 GABA
Topics: Analgesia; Analgesics; Animals; Brain-Derived Neurotrophic Factor; Chlorides; Disease Models, Animal; Fluorobenzenes; GABA-A Receptor Agonists; Ion Transport; K Cl- Cotransporters; Ligands; Male; Neuralgia; Neurons; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, GABA-A; Symporters; Synapses; Triazoles | 2020 |