Page last updated: 2024-12-06

glycolamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Glycolamide is an organic compound with the formula NH2CH2CO2H. It is a white solid that is soluble in water. Glycolamide is a versatile building block for the synthesis of a variety of compounds, including pharmaceuticals, polymers, and agricultural chemicals. Glycolamide has been investigated as a potential agent for the treatment of diabetes, cancer, and inflammation. Glycolamide has been shown to have anti-inflammatory properties, and it is currently being investigated as a potential treatment for inflammatory bowel disease. Glycolamide is also being studied for its potential use in the synthesis of biodegradable polymers. It is a building block for the synthesis of peptides, amino acids, and other important organic molecules. Glycolamide is a chiral molecule, meaning it exists in two enantiomeric forms. The L-enantiomer is naturally occurring, while the D-enantiomer is synthetic. Glycolamide is a versatile compound with a wide range of potential applications.'

Cross-References

ID SourceID
PubMed CID69021
CHEBI ID30321
MeSH IDM0152645

Synonyms (34)

Synonym
EN300-42421
BB 0216360
glycollamide
CHEBI:30321
2-hydroxyacetamide
2-hydroxyacetimidic acid
glycolamide
598-42-5
nsc97323
acetamide, 2-hydroxy-
nsc-97323
glycolamide, 98%
STK070128
18eak3ur7c ,
nsc 97323
unii-18eak3ur7c
AKOS005389776
FT-0677166
2-hydroxy-acetamide
TZGPACAKMCUCKX-UHFFFAOYSA-N
mfcd00047895
DTXSID70208531
F9995-4160
n-hydroxyacetamide, aldrichcpr
glycolic acid amide
glycolic amide
Q27111657
CS-W016686
D77798
glykolsa currencyureamid
AS-57066
SB83802
SY039316
Z424788508

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" This article describes the discovery of 2-phenyl-4-piperazinylbenzimidazoles as small molecule GnRH antagonists with nanomolar potency in in vitro binding and functional assays, excellent bioavailability (rat %F>70) and demonstrated oral activity in a rat model having shown significant serum leuteinizing hormone (LH) suppression."( 2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor.
Chengalvala, M; Cottom, J; Feingold, I; Garrick, L; Green, D; Hauze, D; Huselton, C; Jetter, J; Kao, W; Kopf, GS; Lundquist, JT; Mann, C; Mehlmann, J; Pelletier, JC; Rogers, J; Shanno, L; Wrobel, J, 2008
)
0.35

Dosage Studied

ExcerptRelevanceReference
" In this in vivo study, oil solutions of the N,N-diethyl glycolamide ester prodrug of naproxen (16 mg/ml) were injected into the rat knee joint by dosing 6 μl formulation per 100g body weight."( Prolonged naproxen joint residence time after intra-articular injection of lipophilic solutions comprising a naproxen glycolamide ester prodrug in the rat.
Agårdh, L; He, W; Larsen, C; Larsen, F; Larsen, SW; Lu, Y; Ostergaard, J; Thing, M; Wu, W, 2013
)
0.84
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
acetamidesCompounds with the general formula RNHC(=O)CH3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.88)18.7374
1990's1 (5.88)18.2507
2000's7 (41.18)29.6817
2010's7 (41.18)24.3611
2020's1 (5.88)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.19 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index5.29 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]