3,4,6-tri-o-acetylglucal

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,4,6-tri-o-acetylglucal is a synthetic derivative of glucal, a naturally occurring sugar. It is synthesized by acetylation of glucal, typically using acetic anhydride and a base catalyst. 3,4,6-tri-o-acetylglucal is a versatile building block in organic synthesis, particularly for the preparation of glycosides and other carbohydrate derivatives. It has been studied extensively for its potential applications in medicinal chemistry and carbohydrate chemistry. For example, it has been used in the synthesis of antiviral agents, anti-inflammatory drugs, and carbohydrate mimetics. The compound's unique reactivity and structural features make it a valuable tool for exploring the synthesis of novel carbohydrate-based molecules.'

3,4,6-tri-O-acetylglucal: RN given refers to (D)-isomer with unspecified acetate locants [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	102891
SCHEMBL ID	12083311
MeSH ID	M0127571

Synonyms (33)

Synonym
d-arabino-hex-1-enitol, 1,5-anhydro-2-deoxy-, triacetate
LS-14102
nsc66181
nsc-66181
nsc287428
nsc-287428
(3,4-diacetyloxy-3,4-dihydro-2h-pyran-2-yl)methyl acetate
d-glucal triacetate
einecs 223-859-5
3,4,6-tri-o-acetylglucal
2,6-anhydro-5-deoxy-d-arabino-hex-5-enitol triacetate
1,5-anhydro-2-deoxy-d-arabino-hex-1-enitol triacetate
einecs 220-709-0
FT-0624544
FT-0634522
AM84889
tri-o-acetylglucal
SY009244
mfcd00063253
SCHEMBL12083311
d-arabino-hex-1-enopyranose, 1,2-dideoxy-, triacetate
LLPWGHLVUPBSLP-UHFFFAOYSA-N
tri-o-acetyl-l-glucal
1,3,4-tri-o-acetyl-2,6-anhydro-5-deoxyhex-5-enitol
AKOS030212726
mfcd00064092
SY017625
FT-0773735
d-arabino-hex-1-enitol, 1,5-anhydro-2-deoxy-, 3,4,6-triacetate
1,5-anhydro-2-deoxy-d-arabino-hex-1-enitol3,4,6-tri-o-acetyl
DTXSID90863045
2-(acetoxymethyl)-3,4-dihydro-2h-pyran-3,4-diyl (2r,3s,4s)-diacetate
SY356451

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (9.09)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (45.45)	29.6817
2010's	3 (27.27)	24.3611
2020's	2 (18.18)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.85 (24.57)
Research Supply Index	2.48 (2.92)
Research Growth Index	4.34 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.85)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
malic acid malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.. 2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.	2.01	1	2-hydroxydicarboxylic acid; C4-dicarboxylic acid	food acidity regulator; fundamental metabolite
cyanides Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.	2.01	1	pseudohalide anion	EC 1.9.3.1 (cytochrome c oxidase) inhibitor
4-toluenesulfonyl chloride [no description available]	2	1
calcium gluconate [no description available]	2.6	1	calcium salt	nutraceutical
cellobiose beta-cellobiose : A cellobiose with beta configuration at the reducing-end glucose residue.	2.01	1	cellobiose	epitope
glycidol glycidol: structure given in first source	2.01	1	epoxide; primary alcohol
mercury Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.	2.01	1	elemental mercury; zinc group element atom	neurotoxin
iodine [no description available]	2.11	1	halide anion; monoatomic iodine	human metabolite
triethyl phosphite triethyl phosphite: RN given refers to parent cpd; structure	2	1
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2.75	3	1,2,3-triazole
allyltrimethylsilane allyltrimethylsilane: used to make allyl C-glycosylic compounds	2	1
phosphites Phosphites: Inorganic salts or organic esters of phosphorous acid that contain the (3-)PO3 radical. (From Grant & Hackh's Chemical Dictionary, 5th ed). phosphite(3-) : A trivalent inorganic anion obtained by removal of all three protons from phosphorous acid.	2	1	phosphite ion; trivalent inorganic anion
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	3.63	9
cellobial cellobial: RN & structure given in first source	2.01	1
glycosides [no description available]	2	1
d-glucal [no description available]	1.96	1
lithium tetrafluoroborate [no description available]	2	1

Condition	Relationship Strength	Studies
Plasmodium falciparum Malaria [description not available]	2.1	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.1	1
Cytomegalovirus A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.	2.06	1

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