Compounds > 3,4,6-tri-o-acetylglucal
Page last updated: 2024-11-07

3,4,6-tri-o-acetylglucal

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,4,6-tri-o-acetylglucal is a synthetic derivative of glucal, a naturally occurring sugar. It is synthesized by acetylation of glucal, typically using acetic anhydride and a base catalyst. 3,4,6-tri-o-acetylglucal is a versatile building block in organic synthesis, particularly for the preparation of glycosides and other carbohydrate derivatives. It has been studied extensively for its potential applications in medicinal chemistry and carbohydrate chemistry. For example, it has been used in the synthesis of antiviral agents, anti-inflammatory drugs, and carbohydrate mimetics. The compound's unique reactivity and structural features make it a valuable tool for exploring the synthesis of novel carbohydrate-based molecules.'

3,4,6-tri-O-acetylglucal: RN given refers to (D)-isomer with unspecified acetate locants [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID102891
SCHEMBL ID12083311
MeSH IDM0127571

Synonyms (33)

Synonym
d-arabino-hex-1-enitol, 1,5-anhydro-2-deoxy-, triacetate
LS-14102
nsc66181
nsc-66181
nsc287428
nsc-287428
(3,4-diacetyloxy-3,4-dihydro-2h-pyran-2-yl)methyl acetate
d-glucal triacetate
einecs 223-859-5
3,4,6-tri-o-acetylglucal
2,6-anhydro-5-deoxy-d-arabino-hex-5-enitol triacetate
1,5-anhydro-2-deoxy-d-arabino-hex-1-enitol triacetate
einecs 220-709-0
FT-0624544
FT-0634522
AM84889
tri-o-acetylglucal
SY009244
mfcd00063253
SCHEMBL12083311
d-arabino-hex-1-enopyranose, 1,2-dideoxy-, triacetate
LLPWGHLVUPBSLP-UHFFFAOYSA-N
tri-o-acetyl-l-glucal
1,3,4-tri-o-acetyl-2,6-anhydro-5-deoxyhex-5-enitol
AKOS030212726
mfcd00064092
SY017625
FT-0773735
d-arabino-hex-1-enitol, 1,5-anhydro-2-deoxy-, 3,4,6-triacetate
1,5-anhydro-2-deoxy-d-arabino-hex-1-enitol3,4,6-tri-o-acetyl
DTXSID90863045
2-(acetoxymethyl)-3,4-dihydro-2h-pyran-3,4-diyl (2r,3s,4s)-diacetate
SY356451
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (9.09)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's3 (27.27)24.3611
2020's2 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.85 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.34 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
malic acid
malic acid : A 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.. 2-hydroxydicarboxylic acid : Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.		2.01102-hydroxydicarboxylic acid;
C4-dicarboxylic acid		food acidity regulator;
fundamental metabolite
cyanides
Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.		2.0110pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
4-toluenesulfonyl chloride
[no description available]		210
calcium gluconate
[no description available]		2.610calcium saltnutraceutical
cellobiose
beta-cellobiose : A cellobiose with beta configuration at the reducing-end glucose residue.		2.0110cellobioseepitope
glycidol
glycidol: structure given in first source		2.0110epoxide;
primary alcohol
mercury
Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.		2.0110elemental mercury;
zinc group element atom		neurotoxin
iodine
[no description available]		2.1110halide anion;
monoatomic iodine		human metabolite
triethyl phosphite
triethyl phosphite: RN given refers to parent cpd; structure		210
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.75301,2,3-triazole
allyltrimethylsilane
allyltrimethylsilane: used to make allyl C-glycosylic compounds		210
phosphites
Phosphites: Inorganic salts or organic esters of phosphorous acid that contain the (3-)PO3 radical. (From Grant & Hackh's Chemical Dictionary, 5th ed). phosphite(3-) : A trivalent inorganic anion obtained by removal of all three protons from phosphorous acid.		210phosphite ion;
trivalent inorganic anion
deoxyglucose
Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.		3.6390
cellobial
cellobial: RN & structure given in first source		2.0110
glycosides
[no description available]		210
d-glucal
[no description available]		1.9610
lithium tetrafluoroborate
[no description available]		210
ConditionIndicatedRelationship StrengthStudiesTrials
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		02.0610