furamidine profile

furamidine: RN given refers to parent cpd; WR 199385 refers to di-HCl; pafuramidine is a prodrug of this [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	126437
CHEMBL ID	24057
SCHEMBL ID	549198
MeSH ID	M0103342

Synonym
NCI60_002601
4,4'-(2,5-furandiyl)bis(benzenecarboximidamide)
2,5-bis(4-amidinophenyl)furan
brn 1435532
db 75
benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis-, dihydrochloride
nsc305831 ,
nsc-305831
2,5-bis(4-amidinophenyl)-furan
db75
furamidine
furandiamidine
benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis-
NCGC00014688
BGF ,
NCI305831
NCISTRUC1_001694
NCISTRUC2_001468
NCGC00097791-01
NCGC00097791-02
CHEMBL24057
4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzenecarboximidamide
73819-26-8
bdbm50388602
CCG-37385
NCGC00014688-03
NCGC00014688-02
unii-08gh1yf0ra
08gh1yf0ra ,
5-18-07-00177 (beilstein handbook reference)
furamidine-d8
furamidine dihydrochloride
SCHEMBL549198
DTXSID00224264
AKOS030254780
HY-110137A
336786-81-3
db75;nsc 305831
db-75
4,4'-(2,5-furandiyl)bis [benzenecarboximidamide]
NCGC00014688-06
CS-0058706
4,4'-(furan-2,5-diyl)dibenzimidamide
73819-26-8 (free base)

Excerpt	Reference	Relevance
"Furamidine is an effective antimicrobial agent; however, oral potency of furamidine is poor. "	( Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase. Anbazhagan, M; Boykin, DW; Bridges, AS; Hall, JE; Kurian, JR; Saulter, JY; Stephens, CE; Tidwell, RR; Trepanier, LA, 2005)	1.77
"Pafuramidine is a novel orally active antimalarial. "	( Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro. Meshnick, SR; Purfield, AE; Tidwell, RR, 2008)	1.07

Excerpt	Reference	Relevance
" In this study, we aimed to determine the mechanisms underlying the differential efficacies of these diamidines against HAT by conducting a comprehensive pharmacokinetic characterization."	( Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis. Boykin, DW; Brun, R; Miller, PN; Wang, MZ; Wenzler, T; Wu, H; Yang, S, 2014)	0.4

Excerpt	Reference	Relevance
" However, DB75 does not exhibit significant oral bioavailability and has proved to be ineffective against mouse models of late-stage sleeping sickness regardless of administration route."	( Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue. Bagnell, CR; Brock, JL; Hall, JE; Sturk, LM; Tidwell, RR, 2004)	0.32
" Oral doses were well absorbed (approximately 50-70%) and effectively converted to DB75 in both species but subject to first-pass metabolism and hepatic retention, limiting its systemic bioavailability to 10 to 20%."	( Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride). Boykin, DW; Cybulski, ZR; Fitzpatrick, K; Henderson, SJ; Houchen, TL; John, BA; McBurney, A; Midgley, I; Taylor, LM; Trendler, KL; Wright, SJ, 2007)	0.34
" An orally bioavailable prodrug of CPD-0801, DB868, is metabolized primarily in the liver to the active form."	( Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo. Generaux, CN; Goldsmith, RB; Gray, DR; Reisner, HM; Tidwell, RR; Yan, Z, 2010)	0.36

Excerpt	Relevance	Reference
"1% of control when administered at a dosage of 10 mumol/kg."	( 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. Bender, BC; Boykin, DW; Hall, JE; Kumar, A; McCurdy, DR; Tidwell, RR; Wilson, WD; Xiao, G, 1998)	0.3
"1% of control when administered at a dosage of 10 micromol/kg."	( Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. Bajic, M; Bender, BC; Boykin, DW; Hall, JE; Hopkins, KT; Kumar, A; McCurdy, DR; Tidwell, RR; Wilson, WD, 1998)	0.3
" The in vivo results show that the 4-fluorophenyl carbamate 8 and the 4-methoxyphenyl carbamate 9 in this series had the best anti-PCP activity by both intravenous and oral administration at a dosage level of 22 mol and 33 micromol/kg/day, respectively."	( Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan. Bender, BC; Boykin, DW; Hall, JE; McCurdy, DR; Rahmathullah, SM; Tidwell, RR, 1999)	0.3
" Compound 6a produced cures at an oral dosage of 5 mg/kg."	( Synthesis and antiprotozoal activity of aza-analogues of furamidine. Boykin, DW; Brun, R; Easterbrook, JD; Ismail, MA; Tanious, FA; Wilson, WD, 2003)	0.56
" Although effective treatments for early-stage sleeping sickness exist, these drugs usually require extended dosing schedules and intravenous administration."	( Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue. Bagnell, CR; Brock, JL; Hall, JE; Sturk, LM; Tidwell, RR, 2004)	0.32
" Complete cures were achieved with oral dosing of the prodrug DB289 in all three models without any overt toxicity."	( Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis. Brun, R; Kagira, JM; Karanja, SM; Mdachi, RE; Ngotho, JM; Thuita, JK; Tidwell, R; Wenzler, T, 2008)	0.35
" Sixteen healthy volunteers were dosed and challenged in a single cohort."	( Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites. Bakshi, RP; Hendrix, CW; Kumar, N; Nyunt, MM; Shapiro, TA, 2009)	0.59
" rhodesiense in vivo, curing three of four infected mice dosed intraperitoneally at 5 mg/kg x 4 days."	( Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. Bakunov, SA; Bakunova, SM; Barzcz, T; Brun, R; Chen, H; Jones, SK; Kumar, EV; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA, 2009)	0.35
" The amidoxime and N-methoxyamidine of 5a were the only produgs to provide cures (1/4 cures) in the same mouse model on oral dosage at 4x25mg/kg."	( Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. Boykin, DW; Branowska, D; Brun, R; Farahat, AA; Kumar, A; Liu, Y; Wenzler, T; Wilson, WD, 2010)	0.36

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, HADH2 protein	Homo sapiens (human)	Potency	5.1453	0.0251	20.2376	39.8107	AID886; AID893
Chain B, HADH2 protein	Homo sapiens (human)	Potency	5.1453	0.0251	20.2376	39.8107	AID886; AID893
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	57.4571	0.1000	20.8793	79.4328	AID588453; AID588456
TDP1 protein	Homo sapiens (human)	Potency	7.1264	0.0008	11.3822	44.6684	AID686978; AID686979
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	4.4668	0.0112	12.4002	100.0000	AID1030
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	5.0119	0.2818	9.7212	35.4813	AID2326
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	3.5481	0.0018	15.6638	39.8107	AID894
flap endonuclease 1	Homo sapiens (human)	Potency	39.8107	0.1337	25.4129	89.1251	AID588795
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	10.0000	0.0501	27.0736	89.1251	AID588590
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	12.5893	0.0316	22.3146	100.0000	AID588579
caspase-1 isoform alpha precursor	Homo sapiens (human)	Potency	3.9811	0.0003	11.4484	31.6228	AID900
Caspase-7	Homo sapiens (human)	Potency	3.9811	3.9811	18.5856	31.6228	AID889
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Protein arginine N-methyltransferase 5	Homo sapiens (human)	IC50 (µMol)	211.0000	0.0090	0.6915	8.6000	AID1128526; AID1506648
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	IC50 (µMol)	0.0350	0.0027	1.6287	9.9000	AID1391153
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	IC50 (µMol)	5.8550	0.0007	1.6003	10.0000	AID1235076; AID1235077
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	IC50 (µMol)	5.8550	0.0007	1.6306	10.0000	AID1235076; AID1235077
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	IC50 (µMol)	5.8550	0.0006	1.5257	10.0000	AID1235076; AID1235077
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	IC50 (µMol)	5.8550	0.0007	1.7472	10.0000	AID1235076; AID1235077
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	IC50 (µMol)	5.8550	0.0007	1.7411	10.0000	AID1235076; AID1235077
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	IC50 (µMol)	5.8550	0.0007	1.7411	10.0000	AID1235076; AID1235077
Protein arginine N-methyltransferase 1	Homo sapiens (human)	IC50 (µMol)	13.4333	0.2500	3.6167	9.4000	AID1128525; AID1506647; AID1685557
Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)	IC50 (µMol)	10.9450	0.0120	3.3213	8.4300	AID1398692; AID1532278; AID1532280; AID1851331; AID673458; AID703983
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	IC50 (µMol)	5.8550	0.0007	1.7411	10.0000	AID1235076; AID1235077
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Protein arginine N-methyltransferase 1	Homo sapiens (human)	Kis	2.6000	2.6000	2.6000	2.6000	AID1128529
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
peptidyl-arginine N-methylation	Protein arginine N-methyltransferase 5	Homo sapiens (human)
spliceosomal snRNP assembly	Protein arginine N-methyltransferase 5	Homo sapiens (human)
chromatin remodeling	Protein arginine N-methyltransferase 5	Homo sapiens (human)
DNA-templated transcription termination	Protein arginine N-methyltransferase 5	Homo sapiens (human)
regulation of mitotic nuclear division	Protein arginine N-methyltransferase 5	Homo sapiens (human)
peptidyl-arginine methylation	Protein arginine N-methyltransferase 5	Homo sapiens (human)
circadian regulation of gene expression	Protein arginine N-methyltransferase 5	Homo sapiens (human)
endothelial cell activation	Protein arginine N-methyltransferase 5	Homo sapiens (human)
negative regulation of gene expression via chromosomal CpG island methylation	Protein arginine N-methyltransferase 5	Homo sapiens (human)
negative regulation of cell differentiation	Protein arginine N-methyltransferase 5	Homo sapiens (human)
negative regulation of DNA-templated transcription	Protein arginine N-methyltransferase 5	Homo sapiens (human)
positive regulation of mRNA splicing, via spliceosome	Protein arginine N-methyltransferase 5	Homo sapiens (human)
positive regulation of oligodendrocyte differentiation	Protein arginine N-methyltransferase 5	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Protein arginine N-methyltransferase 5	Homo sapiens (human)
Golgi ribbon formation	Protein arginine N-methyltransferase 5	Homo sapiens (human)
liver regeneration	Protein arginine N-methyltransferase 5	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Protein arginine N-methyltransferase 5	Homo sapiens (human)
positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway	Protein arginine N-methyltransferase 5	Homo sapiens (human)
regulation of DNA-templated transcription	Protein arginine N-methyltransferase 5	Homo sapiens (human)
quinone catabolic process	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
proteolysis	Caspase-7	Homo sapiens (human)
apoptotic process	Caspase-7	Homo sapiens (human)
heart development	Caspase-7	Homo sapiens (human)
response to UV	Caspase-7	Homo sapiens (human)
protein processing	Caspase-7	Homo sapiens (human)
protein catabolic process	Caspase-7	Homo sapiens (human)
defense response to bacterium	Caspase-7	Homo sapiens (human)
fibroblast apoptotic process	Caspase-7	Homo sapiens (human)
striated muscle cell differentiation	Caspase-7	Homo sapiens (human)
neuron apoptotic process	Caspase-7	Homo sapiens (human)
protein maturation	Caspase-7	Homo sapiens (human)
lymphocyte apoptotic process	Caspase-7	Homo sapiens (human)
cellular response to lipopolysaccharide	Caspase-7	Homo sapiens (human)
cellular response to staurosporine	Caspase-7	Homo sapiens (human)
execution phase of apoptosis	Caspase-7	Homo sapiens (human)
positive regulation of plasma membrane repair	Caspase-7	Homo sapiens (human)
positive regulation of neuron apoptotic process	Caspase-7	Homo sapiens (human)
regulation of DNA-templated transcription	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
positive regulation of cell population proliferation	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
methylation	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
regulation of intracellular estrogen receptor signaling pathway	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
positive regulation of fat cell differentiation	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase I	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
response to cAMP	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
replication fork reversal	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
positive regulation of epithelial cell apoptotic process	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
negative regulation of dendrite development	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
chromatin remodeling	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Protein arginine N-methyltransferase 6	Homo sapiens (human)
base-excision repair	Protein arginine N-methyltransferase 6	Homo sapiens (human)
regulation of mitochondrion organization	Protein arginine N-methyltransferase 6	Homo sapiens (human)
methylation	Protein arginine N-methyltransferase 6	Homo sapiens (human)
protein modification process	Protein arginine N-methyltransferase 6	Homo sapiens (human)
regulation of megakaryocyte differentiation	Protein arginine N-methyltransferase 6	Homo sapiens (human)
negative regulation of DNA-templated transcription	Protein arginine N-methyltransferase 6	Homo sapiens (human)
cellular senescence	Protein arginine N-methyltransferase 6	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Protein arginine N-methyltransferase 6	Homo sapiens (human)
negative regulation of ubiquitin-dependent protein catabolic process	Protein arginine N-methyltransferase 6	Homo sapiens (human)
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	Protein arginine N-methyltransferase 6	Homo sapiens (human)
chromatin remodeling	Protein arginine N-methyltransferase 6	Homo sapiens (human)
in utero embryonic development	Protein arginine N-methyltransferase 1	Homo sapiens (human)
protein methylation	Protein arginine N-methyltransferase 1	Homo sapiens (human)
DNA damage response	Protein arginine N-methyltransferase 1	Homo sapiens (human)
cell surface receptor signaling pathway	Protein arginine N-methyltransferase 1	Homo sapiens (human)
positive regulation of cell population proliferation	Protein arginine N-methyltransferase 1	Homo sapiens (human)
RNA splicing	Protein arginine N-methyltransferase 1	Homo sapiens (human)
peptidyl-arginine methylation	Protein arginine N-methyltransferase 1	Homo sapiens (human)
viral protein processing	Protein arginine N-methyltransferase 1	Homo sapiens (human)
regulation of BMP signaling pathway	Protein arginine N-methyltransferase 1	Homo sapiens (human)
neuron projection development	Protein arginine N-methyltransferase 1	Homo sapiens (human)
positive regulation of erythrocyte differentiation	Protein arginine N-methyltransferase 1	Homo sapiens (human)
regulation of megakaryocyte differentiation	Protein arginine N-methyltransferase 1	Homo sapiens (human)
negative regulation of megakaryocyte differentiation	Protein arginine N-methyltransferase 1	Homo sapiens (human)
positive regulation of translation	Protein arginine N-methyltransferase 1	Homo sapiens (human)
negative regulation of JNK cascade	Protein arginine N-methyltransferase 1	Homo sapiens (human)
positive regulation of hemoglobin biosynthetic process	Protein arginine N-methyltransferase 1	Homo sapiens (human)
cardiac muscle tissue development	Protein arginine N-methyltransferase 1	Homo sapiens (human)
protein homooligomerization	Protein arginine N-methyltransferase 1	Homo sapiens (human)
cellular response to methionine	Protein arginine N-methyltransferase 1	Homo sapiens (human)
positive regulation of p38MAPK cascade	Protein arginine N-methyltransferase 1	Homo sapiens (human)
positive regulation of TORC1 signaling	Protein arginine N-methyltransferase 1	Homo sapiens (human)
positive regulation of double-strand break repair via homologous recombination	Protein arginine N-methyltransferase 1	Homo sapiens (human)
chromatin remodeling	Protein arginine N-methyltransferase 1	Homo sapiens (human)
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	Protein arginine N-methyltransferase 1	Homo sapiens (human)
single strand break repair	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
DNA repair	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
double-strand break repair	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
p53 binding	Protein arginine N-methyltransferase 5	Homo sapiens (human)
transcription corepressor activity	Protein arginine N-methyltransferase 5	Homo sapiens (human)
protein binding	Protein arginine N-methyltransferase 5	Homo sapiens (human)
methyltransferase activity	Protein arginine N-methyltransferase 5	Homo sapiens (human)
methyl-CpG binding	Protein arginine N-methyltransferase 5	Homo sapiens (human)
protein-arginine N-methyltransferase activity	Protein arginine N-methyltransferase 5	Homo sapiens (human)
protein-arginine omega-N symmetric methyltransferase activity	Protein arginine N-methyltransferase 5	Homo sapiens (human)
histone methyltransferase activity	Protein arginine N-methyltransferase 5	Homo sapiens (human)
identical protein binding	Protein arginine N-methyltransferase 5	Homo sapiens (human)
ribonucleoprotein complex binding	Protein arginine N-methyltransferase 5	Homo sapiens (human)
histone H4R3 methyltransferase activity	Protein arginine N-methyltransferase 5	Homo sapiens (human)
protein heterodimerization activity	Protein arginine N-methyltransferase 5	Homo sapiens (human)
E-box binding	Protein arginine N-methyltransferase 5	Homo sapiens (human)
histone H3 methyltransferase activity	Protein arginine N-methyltransferase 5	Homo sapiens (human)
histone arginine N-methyltransferase activity	Protein arginine N-methyltransferase 5	Homo sapiens (human)
dihydronicotinamide riboside quinone reductase activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
protein binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
zinc ion binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
electron transfer activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
oxidoreductase activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
oxidoreductase activity, acting on other nitrogenous compounds as donors	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
chloride ion binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
protein homodimerization activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
FAD binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
melatonin binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
resveratrol binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
NAD(P)H dehydrogenase (quinone) activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
RNA binding	Caspase-7	Homo sapiens (human)
aspartic-type endopeptidase activity	Caspase-7	Homo sapiens (human)
cysteine-type endopeptidase activity	Caspase-7	Homo sapiens (human)
protein binding	Caspase-7	Homo sapiens (human)
peptidase activity	Caspase-7	Homo sapiens (human)
cysteine-type peptidase activity	Caspase-7	Homo sapiens (human)
cysteine-type endopeptidase activity involved in apoptotic process	Caspase-7	Homo sapiens (human)
cysteine-type endopeptidase activity involved in execution phase of apoptosis	Caspase-7	Homo sapiens (human)
transcription cis-regulatory region binding	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
transcription coactivator activity	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
protein binding	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
beta-catenin binding	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
protein methyltransferase activity	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
histone arginine N-methyltransferase activity	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
protein-arginine N-methyltransferase activity	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
nuclear receptor coactivator activity	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
protein-arginine omega-N asymmetric methyltransferase activity	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
histone H3R17 methyltransferase activity	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
histone methyltransferase activity	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
lysine-acetylated histone binding	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
histone H3R2 methyltransferase activity	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
DNA-binding transcription factor binding	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
chromatin binding	Protein arginine N-methyltransferase 6	Homo sapiens (human)
protein binding	Protein arginine N-methyltransferase 6	Homo sapiens (human)
histone arginine N-methyltransferase activity	Protein arginine N-methyltransferase 6	Homo sapiens (human)
protein-arginine N-methyltransferase activity	Protein arginine N-methyltransferase 6	Homo sapiens (human)
protein-arginine omega-N monomethyltransferase activity	Protein arginine N-methyltransferase 6	Homo sapiens (human)
protein-arginine omega-N asymmetric methyltransferase activity	Protein arginine N-methyltransferase 6	Homo sapiens (human)
histone methyltransferase activity	Protein arginine N-methyltransferase 6	Homo sapiens (human)
histone binding	Protein arginine N-methyltransferase 6	Homo sapiens (human)
histone H4R3 methyltransferase activity	Protein arginine N-methyltransferase 6	Homo sapiens (human)
histone H3R2 methyltransferase activity	Protein arginine N-methyltransferase 6	Homo sapiens (human)
histone H2AR3 methyltransferase activity	Protein arginine N-methyltransferase 6	Homo sapiens (human)
histone H3 methyltransferase activity	Protein arginine N-methyltransferase 6	Homo sapiens (human)
RNA binding	Protein arginine N-methyltransferase 1	Homo sapiens (human)
protein binding	Protein arginine N-methyltransferase 1	Homo sapiens (human)
methyltransferase activity	Protein arginine N-methyltransferase 1	Homo sapiens (human)
N-methyltransferase activity	Protein arginine N-methyltransferase 1	Homo sapiens (human)
protein methyltransferase activity	Protein arginine N-methyltransferase 1	Homo sapiens (human)
methyl-CpG binding	Protein arginine N-methyltransferase 1	Homo sapiens (human)
protein-arginine N-methyltransferase activity	Protein arginine N-methyltransferase 1	Homo sapiens (human)
enzyme binding	Protein arginine N-methyltransferase 1	Homo sapiens (human)
protein-arginine omega-N monomethyltransferase activity	Protein arginine N-methyltransferase 1	Homo sapiens (human)
protein-arginine omega-N asymmetric methyltransferase activity	Protein arginine N-methyltransferase 1	Homo sapiens (human)
histone methyltransferase activity	Protein arginine N-methyltransferase 1	Homo sapiens (human)
identical protein binding	Protein arginine N-methyltransferase 1	Homo sapiens (human)
histone H4R3 methyltransferase activity	Protein arginine N-methyltransferase 1	Homo sapiens (human)
mitogen-activated protein kinase p38 binding	Protein arginine N-methyltransferase 1	Homo sapiens (human)
GATOR1 complex binding	Protein arginine N-methyltransferase 1	Homo sapiens (human)
S-adenosyl-L-methionine binding	Protein arginine N-methyltransferase 1	Homo sapiens (human)
double-stranded DNA binding	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
single-stranded DNA binding	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
exonuclease activity	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
protein binding	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
3'-tyrosyl-DNA phosphodiesterase activity	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Protein arginine N-methyltransferase 5	Homo sapiens (human)
nucleoplasm	Protein arginine N-methyltransferase 5	Homo sapiens (human)
Golgi apparatus	Protein arginine N-methyltransferase 5	Homo sapiens (human)
cytosol	Protein arginine N-methyltransferase 5	Homo sapiens (human)
methylosome	Protein arginine N-methyltransferase 5	Homo sapiens (human)
chromatin	Protein arginine N-methyltransferase 5	Homo sapiens (human)
cytoplasm	Protein arginine N-methyltransferase 5	Homo sapiens (human)
histone methyltransferase complex	Protein arginine N-methyltransferase 5	Homo sapiens (human)
cytosol	Protein arginine N-methyltransferase 5	Homo sapiens (human)
nucleus	Protein arginine N-methyltransferase 5	Homo sapiens (human)
nucleoplasm	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
cytosol	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
extracellular exosome	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
cytosol	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
endoplasmic reticulum membrane	Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)
plasma membrane	Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)
extracellular space	Caspase-7	Homo sapiens (human)
nucleus	Caspase-7	Homo sapiens (human)
cytoplasm	Caspase-7	Homo sapiens (human)
cytosol	Caspase-7	Homo sapiens (human)
nucleus	Caspase-7	Homo sapiens (human)
nucleoplasm	Caspase-7	Homo sapiens (human)
cytosol	Caspase-7	Homo sapiens (human)
endoplasmic reticulum membrane	Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)
plasma membrane	Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)
endoplasmic reticulum membrane	Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)
plasma membrane	Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)
endoplasmic reticulum membrane	Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)
plasma membrane	Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)
endoplasmic reticulum membrane	Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)
plasma membrane	Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)
nuclear replication fork	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
nucleus	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
nucleoplasm	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
cytoplasm	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
cytosol	Histone-arginine methyltransferase CARM1	Homo sapiens (human)
endoplasmic reticulum membrane	Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)
plasma membrane	Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)
nucleus	Protein arginine N-methyltransferase 6	Homo sapiens (human)
nucleoplasm	Protein arginine N-methyltransferase 6	Homo sapiens (human)
nucleolus	Protein arginine N-methyltransferase 6	Homo sapiens (human)
lysosomal membrane	Protein arginine N-methyltransferase 1	Homo sapiens (human)
nucleus	Protein arginine N-methyltransferase 1	Homo sapiens (human)
nucleoplasm	Protein arginine N-methyltransferase 1	Homo sapiens (human)
cytoplasm	Protein arginine N-methyltransferase 1	Homo sapiens (human)
cytosol	Protein arginine N-methyltransferase 1	Homo sapiens (human)
methylosome	Protein arginine N-methyltransferase 1	Homo sapiens (human)
nucleus	Protein arginine N-methyltransferase 1	Homo sapiens (human)
nucleoplasm	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
cytoplasm	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
plasma membrane	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
intracellular membrane-bounded organelle	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
nucleus	Tyrosyl-DNA phosphodiesterase 1	Homo sapiens (human)
endoplasmic reticulum membrane	Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)
plasma membrane	Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (274)

Assay ID	Title	Year	Journal	Article
AID322579	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected mouse model assessed as survival at 5 mg/kg, ip after 4 days	2008	Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2	Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
AID372440	Resistance factor, ratio of IC50 for tbat1 knock out Trypanosoma cruzi BS221 to IC50 for wild type Trypanosoma cruzi BS221	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.
AID228684	In vitro DNA binding affinity to oligo [d(CGCGAATTCGCG)2].	2001	Journal of medicinal chemistry, May-24, Volume: 44, Issue:11	Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.
AID478754	Binding affinity to d(CGCGAATTCGCG)2 dodecamer assessed as change in melting temperature	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Theoretical models of pentamidine analogs activity based on their DNA minor groove complexes.
AID269497	Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as average days of survival at 20 mg/kg, ip	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
AID562487	Antitrypanosomal activity against Trypanosoma brucei gambiense K03048 by Alamar blue assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID191632	Toxicity is evaluated according to a five-level scale ranging from 0 to 5+ at the specified iv dose of 13.3 (umol/kg/day)	1999	Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19	Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan.
AID779102	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as mouse survival at 5 mg/kg, ip administered on day 3 post infection for 4 days measured up to 60 days	2013	Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21	Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
AID1235077	Displacement of [3H]-MK-801 from rat cortical membranes NMDA receptor by beta counting analysis in presence of 30 uM spermine	2015	Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15	Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.
AID1767951	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation measured after 24 hrs by liquid scintillation counting method
AID551686	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 after 70 hrs by alamar blue assay	2011	Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2	Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
AID173671	In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 13.3 umol/kg/day	1998	Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20	Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID1128530	Uncompetitive inhibition of His6x-tagged recombinant PRMT1 (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]SAM and histone H4 (1 to 20) as substrate by double reciprocal plot analysis	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID53470	Inhibitory dose against oncornaviral DNA polymerase activity of moloney murine leukemia virus	1980	Journal of medicinal chemistry, Jul, Volume: 23, Issue:7	Diaryl amidine derivatives as oncornaviral DNA polymerase inhibitors.
AID1146855	Antitrypanosomal activity against Trypanosoma rhodesiense infected in mouse assessed as increase in survival time by 30 days at 10 mg/kg relative to control	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles.
AID249233	In vivo antitrypanosomal activity (20 mg/kg for 4 days, i.p.) measured as cured mice infected with Trypanosoma brucei rhodesiense strain STIB900; 0 cured out of 4	2005	Journal of medicinal chemistry, Aug-25, Volume: 48, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
AID1426421	Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense after 70 hrs by Alamar blue assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID124114	In vivo average survival rate of mouse infected by T.b. rhodesiense was determined for a period of 60 days at dose of 20 mg/kg by i.p. administration	2003	Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22	Synthesis and antiprotozoal activity of aza-analogues of furamidine.
AID1146852	Antitrypanosomal activity against Trypanosoma rhodesiense infected in mouse assessed as increase in survival time by 30 days at 2.5 mg/kg relative to control	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles.
AID249181	Apparent permeability determined across the Caco-2 cell monolayers in both basolateral (BL) to apical (AP) directions	2004	Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17	O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
AID173669	In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 0.03 umol/kg/day	1998	Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20	Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID1128531	Inhibition of His6x-tagged recombinant PRMT1 (unknown origin) expressed in Escherichia coli BL21(DE3) using fluorescein-labeled histone H4 (1 to 20) as substrate at 10 to 50 uM after 8 mins by competitive fluorescence anisotropy binding assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID372439	Antitrypanosomal activity against tbat1 knockout Trypanosoma cruzi BS221 infected in mouse macrophage by reporter dye assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.
AID1873842	Binding affinity to biotin labeled hairpin DNA 5'-GAATTC-3' (unknown origin) assessed as equilibrium dissociation constant by sensor chip immobilization based surface plasmon resonance analysis	2022	Bioorganic & medicinal chemistry, 08-15, Volume: 68	Drug design and DNA structural research inspired by the Neidle laboratory: DNA minor groove binding and transcription factor inhibition by thiophene diamidines.
AID249190	In vitro cytotoxicity evaluated using cultured L6 rat myoblast cells	2005	Journal of medicinal chemistry, Aug-25, Volume: 48, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
AID779103	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as mouse survival at 20 mg/kg, ip administered on day 3 post infection for 4 days measured up to 60 days	2013	Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21	Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
AID174181	The cysts/g of lung (% of control ) is calculated at a dose of 0.3 umol/kg /day against Pneumocystis carinii in rats	1998	Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1	2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID593435	Binding affinity to poly(dA-dT)2DNA assessed as change in melting temperature	2011	Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7	Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.
AID1128532	Inhibition of PRMT1 in human 293T cells assessed as reduction of GFP-ALY methylation by Western blot analysis	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID286672	Cytotoxic index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
AID1426412	Antiparasitic activity against asexual intraerythrocytic stage of Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID562495	Ratio of IC50 for Trypanosoma brucei gambiense ITMAP141267 to IC50 for wild-type Trypanosoma brucei rhodesiense STIB903	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID562488	Antitrypanosomal activity against Trypanosoma brucei gambiense ITMAP141267 by Alamar blue assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID562485	Antitrypanosomal activity against pentamidine-resistant Trypanosoma brucei rhodesiense STIB900 by Alamar blue assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID42672	In vitro minimum fungicidal concentration against Candida albicans.	2001	Journal of medicinal chemistry, May-24, Volume: 44, Issue:11	Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.
AID1506653	Inhibition of PRMT1 (unknown origin) assessed as reduction in methyl transfer from [14C]SAM to biotinylated histone H4 peptide H4-20-Biotin at 0.2 mM incubated for 30 mins by radiometric gel assay	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
AID382524	Toxicity against immunosuppressed rat pneumocystis model at 39.8 umol/kg/day, po	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1	Carbamate prodrugs of N-alkylfuramidines.
AID212860	In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 0.3 umol/kg/day	1998	Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20	Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID290096	Antiparasitic activity against Trypanosoma cruzi Tulahuen LacZ C4	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
AID598107	Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.
AID243248	Ratio of maximum concentration bound and specificity sum for triplex nucleic acids	2004	Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23	Structural selectivity of aromatic diamidines.
AID213471	In vitro inhibitory activity against Trypanosoma brucei rhodesiense	2004	Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14	Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents.
AID290098	Antitrypanosomal activity in Trypanosoma brucei rhodesiense STIB900 infected mouse at 20 mg/kg, ip administered for 4 days	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
AID551685	Binding affinity to Poly d(A-T)n DNA assessed as change in melting temperature	2011	Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2	Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
AID562514	Antitrypanosomal activity against Trypanosoma brucei brucei GVR35 infected in NMRI mouse CNS model assessed as cure from infection at 20 mg/kg, ip for 5 days	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID1506646	Inhibition of PRMT5 (unknown origin) assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H4-20-Biotin at 100 uM pre-incubated for 3 mins before [3H]-SAM addition and measured after 45 mins by scintillation proximity a	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
AID564073	Antitrypanosomal activity against bloodstream forms of Trypanosoma cruzi YuYu after 24 hrs by light microscopy in presence of 50% mouse blood	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.
AID756894	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
AID228683	In vitro binding affinity to poly dA.dT.	2001	Journal of medicinal chemistry, May-24, Volume: 44, Issue:11	Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.
AID454674	Selectivity ratio of IC50 for Trypanosoma brucei rhodesiense STIB900 to IC50 for Plasmodium falciparum K1	2009	Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18	Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
AID593440	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1	2011	Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7	Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.
AID454672	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900	2009	Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18	Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
AID756883	Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as host mean survival days at 5 mg/kg, ip qd for 4 days	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
AID322577	Antiprotozoal activity against Plasmodium falciparum K1	2008	Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2	Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
AID756893	Antiprotozoal activity against intracellular amastigote form of Trypanosoma cruzi Tulahuen C2C4 expressing LacZ infected in rat L6 cells after 48 hrs	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
AID251284	In vivo antitrypanosomal activity (20 mg/kg for 4 days, i.p.) measured as survival days of mice infected with Trypanosoma brucei rhodesiense strain STIB900	2005	Journal of medicinal chemistry, Aug-25, Volume: 48, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
AID340909	Binding affinity to Clostridium perfringens genomic DNA assessed as decrease in fluorescence intensity at 1 uM by fluorescence spectral method relative to control	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID151198	In vitro inhibitory activity against Plasmodium falciparum	2003	Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22	Synthesis and antiprotozoal activity of aza-analogues of furamidine.
AID290094	Antiparasitic activity against Plasmodium falciparum K1	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
AID161946	The compound was tested in vivo against Pneumocystis carinii pneumonia (PCP) in the immunosuppressed rat model at iv dose of 13.3 (umol/kg/day)	1999	Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19	Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan.
AID521059	Antimicrobial activity against Trypanosoma brucei brucei 427 bloodstream form assessed as inhibition of mitochondrial ATPase activity 10 uM after 10 mins	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID551689	Antiplasmodial activity against Plasmodium falciparum K1 infected in human RBC after 48 hrs by [3H]-hypoxanthine incorporation assay	2011	Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2	Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
AID598109	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.
AID598105	Binding affinity to poly(dA-dT)n DNA assessed as change in melting temperature at 0.3:1 molar compound/DNA ratio by spectrophotometry	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.
AID432049	Cytotoxicity against rat L6 cells	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
AID118270	Number of mice (out of 4) cured from Trypanosoma brucei rhodesiense infection which are parasite free for 60 days was determined at i.p. dose of 20 mg/kg	2004	Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14	Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents.
AID562493	Ratio of IC50 for melasoprol-resistant Trypanosoma brucei rhodesiense STIB900 to IC50 for wild-type Trypanosoma brucei rhodesiense STIB901	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID100421	Inhibitory activity against Leishmania donovani (amastigote)	2003	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12	The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
AID252577	In vivo effect on average days of survival was measured upon intraperitoneal dose at 40 mg/kg in STIB900 mouse model	2004	Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17	O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
AID1146860	Antitrypanosomal activity against Trypanosoma rhodesiense infected in mouse assessed as increase in survival time by 30 days at 320 mg/kg relative to control	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles.
AID1128526	Inhibition of HA-tagged recombinant PRMT5 (unknown origin) expressed in HEK293T cells using [3H]SAM and histone H4 (1 to 20) as substrate after 8 mins by P81 filter binding assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID481848	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 in infected mouse model assessed as host survival time at 5 mg/kg, ip for 4 days	2010	Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10	Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
AID756892	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma cruzi Tulahuen C2C4	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
AID1391153	Inhibition of recombinant human NQO2 assessed as change in rate of decolouration of DCPIP measured over 1 min by spectrophotometric method	2018	Bioorganic & medicinal chemistry letters, 05-01, Volume: 28, Issue:8	Evaluation of analogues of furan-amidines as inhibitors of NQO2.
AID521062	Drug uptake in Trypanosoma brucei brucei 427 bloodstream form nucleus at 1 uM after 5 mins by fluorescence microscopy	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID269493	Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as survival upto 60 days at 20 mg/kg, ip	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
AID117932	In vivo average survival days of mice infected by Trypanosoma brucei rhodesiense was determined for a period of 60 days at i.p. dose of 20 mg/kg	2004	Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14	Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents.
AID286669	Antitrypanosomal activity against Trypanosoma brucei rhodesiense	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
AID562517	Antitrypanosomal activity against Trypanosoma brucei brucei GVR35 infected in NMRI mouse CNS model assessed as survival of mouse at 20 mg/kg, ip for 5 days	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID454675	Cytotoxicity against rat L6 cells	2009	Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18	Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
AID521055	Antimicrobial activity against Trypanosoma brucei brucei 427 bloodstream form assessed as reduction in mitochondrial membrane potential at 1 uM after 1 min using rhodamine 123 exclusion test	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID1506648	Inhibition of PRMT5 (unknown origin) assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H4-20-Biotin pre-incubated for 3 mins before [3H]-SAM addition and measured after 45 mins by scintillation proximity assay	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
AID290099	Survival of Trypanosoma brucei rhodesiense STIB900 infected mouse at 20 mg/kg, ip administered for 4 days	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
AID481844	Antiplasmodial activity against Plasmodium falciparum K1	2010	Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10	Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
AID454679	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as survival days at 5 mg/kg, ip	2009	Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18	Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
AID756891	Antiprotozoal activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
AID521056	Antimicrobial activity against Trypanosoma brucei brucei 427 bloodstream form assessed as reduction in mitochondrial membrane potential at 10 uM after 1 min using rhodamine 123 exclusion test	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID1128536	Antiproliferative activity against human MOLM13 cells with MLL-AF9 translocation assessed as cell viability at 20 uM measured everyday for 3 days by CellTiter-Glo assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID565605	Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as complete cure from microbial infection at 0.20 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.
AID551688	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900	2011	Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2	Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
AID1146859	Antitrypanosomal activity against Trypanosoma rhodesiense infected in mouse assessed as increase in survival time by 30 days at 160 mg/kg relative to control	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles.
AID269498	Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as average days of survival at 5 mg/kg, ip	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
AID212722	Toxicity at a dose of 2.7 umol/kg/day against Pneumocystis carinii in rats	1998	Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1	2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID1426427	Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 24 hrs by Alamar blue assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID246017	In vivo effect (cures) determined by number of mice that survived (0) and are parasite free (8) for 60 days upon intraperitoneal dose, observed in STIB900 mouse model	2004	Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17	O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
AID340906	Drug level in Trypanosoma brucei brucei S427 at 7.5 uM after 8 hrs	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID1426415	Oral bioavailability in Swiss Webster mouse at 30 mg/kg	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID382517	Antimicrobial activity against Pneumocystis carinii in immunosuppressed rat assessed as number of cysts/g of lung at 13.3 umol/kg/day, iv relative to control	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1	Carbamate prodrugs of N-alkylfuramidines.
AID1235079	Displacement of [3H]-ifenprodil from rat cortical membranes NMDA receptor by beta counting analysis in absence of spermine	2015	Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15	Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.
AID1755260	Inhibition of HOXA9 (unknown origin) expressed in reticulocyte lysate system binding to DNA Hoxa9-binding site (5'-biotin-cctctcctctcctGCGATGATTTACGACCGC) (unknown origin) assessed as Hoxa9/DNA remaining complexes at 5 to 10 uM incubated for 20 mins with	2019	Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3	Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model.
AID55635	DNA binding affinity measured as an increase in thermal melting of poly(dA.dT)2	2003	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12	The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
AID756886	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
AID1146856	Antitrypanosomal activity against Trypanosoma rhodesiense infected in mouse assessed as increase in survival time by 30 days at 20 mg/kg relative to control	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles.
AID322576	Antiprotozoan activity against Trypanosoma brucei rhodesiense STIB900	2008	Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2	Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
AID1297654	Binding affinity to AT rich 5'-Biotin-DNA (unknown origin) by surface plasmon resonance analysis	2016	European journal of medicinal chemistry, Jun-30, Volume: 116	An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics.
AID1128525	Inhibition of His6x-tagged recombinant PRMT1 (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]SAM and histone H4 (1 to 20) as substrate after 8 mins by P81 filter binding assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID269490	Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
AID1767954	Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as reduction in parasitemia by measuring time taken to cure at 5 mg/kg, ip measured up to 60 days (Rvb = 11 days)
AID1128528	Inhibition of His6x-tagged PRMT6 (unknown origin) using [3H]SAM and histone H3.1 as substrate at 20 uM after 1 hr by P81 filter binding assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID564075	Antitrypanosomal activity against bloodstream forms of Trypanosoma cruzi CL after 24 hrs by light microscopy in presence of 50% mouse blood	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.
AID340907	Drug level in Trypanosoma brucei brucei S427 at 7.5 uM after 24 hrs	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID248592	In vitro inhibitory activity against Trypanosoma brucei rhodesiense evaluated in acute mouse model of trypanosomiasis	2004	Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17	O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
AID562491	Antitrypanosomal activity against Trypanosoma brucei brucei AT1KO by Alamar blue assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID454680	Binding affinity to DNA assessed as change in melting temperature	2009	Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18	Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
AID765723	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	2013	European journal of medicinal chemistry, Sep, Volume: 67	Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.
AID756890	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
AID1128524	Inhibition of HA-tagged recombinant PRMT5 (unknown origin) expressed in HEK293T cells using [3H]SAM and histone H4 (1 to 20) as substrate at 20 uM after 8 mins by P81 filter binding assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID286674	Cytotoxic index, ratio of IC50 for rat L6 cells to IC50 for chloroquine-resistant Plasmodium falciparum K1	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
AID1128527	Inhibition of GST-tagged CARM1 (unknown origin) using [3H]SAM and histone H3.1 as substrate at 20 uM after 1 hr by P81 filter binding assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID286671	Cytotoxicity against rat L6 cells	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
AID1062629	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 assessed as growth inhibition after 70 hrs by Alamar blue assay	2014	Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1	Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
AID286673	Ratio of cytotoxic index (ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense) of drug to cytotoxic index of furamidine	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
AID1146857	Antitrypanosomal activity against Trypanosoma rhodesiense infected in mouse assessed as increase in survival time by 30 days at 40 mg/kg relative to control	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles.
AID562718	Toxicity in NMRI mouse CNS model at 25 mg/kg, ip for 10 days	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID269492	Cytotoxicity against rat L6 cells	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
AID1146858	Antitrypanosomal activity against Trypanosoma rhodesiense infected in mouse assessed as increase in survival time by 30 days at 80 mg/kg relative to control	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles.
AID1767949	Binding affinity to poly (dA-dT) (unknown origin) assessed as thermal stability by measuring change in melting temperature
AID564072	Antitrypanosomal activity against bloodstream forms of Trypanosoma cruzi Y after 24 hrs by light microscopy in presence of 50% mouse blood	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.
AID1532278	Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.
AID158689	In vitro inhibitory activity for Plasmodium falciparum	2004	Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14	Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents.
AID55634	DNA binding affinity measured as an increase in thermal melting of d(CGCGAATTCGCG)2	2003	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12	The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
AID1128537	Antiproliferative activity against human Jurkat cells assessed as cell viability at 20 uM measured everyday for 3 days by CellTiter-Glo assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID598106	Cytotoxicity against rat L6 cells	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.
AID372438	Antitrypanosomal activity against wild type Trypanosoma cruzi BS221 infected in mouse macrophage by reporter dye assay	2007	Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11	2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.
AID521060	Antimicrobial activity against Trypanosoma brucei brucei 427 bloodstream form assessed as inhibition of mitochondrial ATPase activity at 100 uM after 10 mins	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID54997	In vitro binding affinity towards calf thymus (CT DNA)	2003	Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22	Synthesis and antiprotozoal activity of aza-analogues of furamidine.
AID779107	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 assessed as parasite growth inhibition after 70 hrs by Alamar blue assay	2013	Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21	Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
AID340903	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 after 72 hrs	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID1391154	Antimalarial activity against Plasmodium falciparum 3D7 asexual cultures grown under 5% haematocrit assessed as decrease in parasite DNA level by flow cytometry	2018	Bioorganic & medicinal chemistry letters, 05-01, Volume: 28, Issue:8	Evaluation of analogues of furan-amidines as inhibitors of NQO2.
AID703983	Inhibition of human recombinant Tdp1 assessed as conversion of 14-mer 5'-32P-labeled 3'-phosphotyrosyl DNA substrate N14Y to 14-mer 5'-32P-labeled 3'-phosphate DNA product N14P after 15 mins by PAGE analysis	2012	Journal of medicinal chemistry, Oct-25, Volume: 55, Issue:20	5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.
AID562490	Antitrypanosomal activity against Trypanosoma brucei brucei BS221 by Alamar blue assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID237614	poly(d(A-T)2) binding affinity is measured as change in DNA melting temperature	2005	Journal of medicinal chemistry, Aug-25, Volume: 48, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
AID212867	In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 2.7 umol/kg/day	1998	Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20	Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID673458	Inhibition of Tdp1	2012	Journal of medicinal chemistry, 05-10, Volume: 55, Issue:9	Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
AID765725	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 after 72 hrs by Alamar blue assay	2013	European journal of medicinal chemistry, Sep, Volume: 67	Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.
AID1128523	Inhibition of His6x-tagged recombinant PRMT1 (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]SAM and histone H4 (1 to 20) as substrate at 20 uM after 8 mins by P81 filter binding assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID286676	Selectivity for chloroquine-resistant Plasmodium falciparum K1 over Trypanosoma brucei rhodesiense	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
AID1767952	Selectivity index, ratio of IC50 for cytotoxicity against rat L6 cells to IC50 for antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900
AID1426414	Half life in Swiss Webster mouse at 30 mg/kg, po	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID565606	Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 0.20 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.
AID481842	Binding affinity to poly(dA.dT) assessed as change in melting temperature by spectrophotometry	2010	Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10	Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
AID1426428	Selectivity index, ratio of IC50 for HEK293 cells to IC50 for drug-resistant Plasmodium falciparum Dd2 infected in erythrocytes	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID340905	Binding affinity at d(CGCGAATTCGCG) synthetic oligomer duplex assessed as increase in melting temperature	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID226666	Cell toxicity was evaluated	2003	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12	The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
AID521047	Antimicrobial activity against Trypanosoma brucei brucei 427 bloodstream form assessed as inhibition of glucose-dependent cellular respiration at 300 uM	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID521046	Antimicrobial activity against Trypanosoma brucei brucei 427 bloodstream form assessed as inhibition of glucose-dependent cellular respiration	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID562504	Antitrypanosomal activity against wild-type Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as survival of mouse at 5 mg/kg, ip for 4 days	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID1851332	Cytotoxicity against human HeLa cells	2022	Bioorganic & medicinal chemistry letters, 10-01, Volume: 73	Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking.
AID1235078	Ratio of IC50 for displacement of [3H]-MK-801 from rat cortical membranes NMDA receptor in presence of 30 uM spermine to IC50 for displacement of [3H]-MK-801 from rat cortical membranes NMDA receptor in absence of 30 spermine	2015	Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15	Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.
AID1128535	Antiproliferative activity against human CHRF-288-11 cells harboring trisomy 21 assessed as cell viability at 20 uM measured everyday for 3 days by CellTiter-Glo assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID1506651	Inhibition of PRMT1 (unknown origin) assessed as reduction in methyl transfer from SAM to biotinylated histone H4 peptide H4-20-Biotin at 0.2 mM incubated for 3.5 hrs by mass spectrometry	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
AID551687	Cytotoxicity against rat L6 cells by alamar blue assay	2011	Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2	Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
AID290093	Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
AID756895	Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 after 72 hrs by Alamar Blue assay	2013	Journal of medicinal chemistry, Jul-11, Volume: 56, Issue:13	Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
AID598108	Antiparasitic activity against Plasmodium falciparum K1	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.
AID432047	Antileishmanial activity against Leishmania donovani MHOM/SD/62/1S-CL2D amastigotes	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
AID779106	Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay	2013	Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21	Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
AID598110	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1	2010	Bioorganic & medicinal chemistry, Jan-15, Volume: 18, Issue:2	Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines.
AID1146861	Antitrypanosomal activity against Trypanosoma rhodesiense infected in mouse assessed as increase in survival time by 30 days at 640 mg/kg relative to control	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles.
AID1426429	Selectivity index, ratio of IC50 for HEK293 cells to IC50 for drug-sensitive Plasmodium falciparum 3D7 infected in erythrocytes	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID290095	Antiparasitic activity against Leishmania donovani	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
AID1235076	Displacement of [3H]-MK-801 from rat cortical membranes NMDA receptor by beta counting analysis in absence of spermine	2015	Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15	Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.
AID269494	Antiprotozoal activity in mouse infected with Trypanosoma brucei rhodesiense STIB900 measured as survival upto 60 days at 5 mg/kg, ip	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
AID593437	Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900	2011	Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7	Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.
AID212865	In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 13.3 umol/kg/day	1998	Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20	Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID779108	Binding affinity to poly(dA-dT)2 DNA (unknown origin) assessed as change in melting temperature by spectrophotometric analysis	2013	Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21	Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
AID1426413	Cmax in Swiss Webster mouse at 30 mg/kg, po	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID562502	Antitrypanosomal activity against wild-type Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as survival of mouse at 20 mg/kg, ip for 4 days	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID174194	The cysts/g of lung (% of control ) is calculated at a dose of 2.7 umol/kg/day against Pneumocystis carinii in rats	1998	Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1	2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID521064	Drug uptake in Trypanosoma brucei brucei 427 bloodstream form mitochondria at 100 uM after 5 mins by fluorescence microscopy	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID521063	Drug uptake in Trypanosoma brucei brucei 427 bloodstream form kinetoplast at 1 uM after 5 mins by fluorescence microscopy	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID593436	Cytotoxicity against rat L6 cells	2011	Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7	Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.
AID1426423	Antiparasitic activity against Giardia lamblia	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID765719	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as mean survival days at 5 mg/kg, ip administered for 4 days	2013	European journal of medicinal chemistry, Sep, Volume: 67	Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.
AID593471	Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as mean relapse day of parasitemia at 5 mg/kg, ip for 4 days	2011	Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7	Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.
AID562519	Antitrypanosomal activity against Trypanosoma brucei brucei GVR35 infected in NMRI mouse CNS model assessed as survival of mouse at 10 mg/kg, ip for 10 days	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID562486	Antitrypanosomal activity against melasoprol-resistant Trypanosoma brucei rhodesiense STIB900 by Alamar blue assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID565604	Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as complete cure from microbial infection at 0.25 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.
AID286675	Ratio of cytotoxic index (ratio of IC50 for rat L6 cells to IC50 for chloroquine-resistant Plasmodium falciparum K1) of drug to cytotoxic index of furamidine	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
AID1506654	Inhibition of PRMT1 (unknown origin) assessed as reduction in methyl transfer from [14C]SAM to biotinylated histone H4 peptide H4-20-Biotin at 0.1 mM incubated for 30 mins by radiometric gel assay	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
AID1398692	Inhibition of recombinant Tdp1 (unknown origin) using 5'-(5,6 FAM-aac gtc agg gtc ttc c-BHQ1)-3' as substrate measured every 55 secs for 8 mins by fluorimetric assay	2018	Bioorganic & medicinal chemistry, 08-15, Volume: 26, Issue:15	Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.
AID340904	Binding affinity to poly(dA).poly(dT) assessed as increase in melting temperature	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID213672	Inhibitory activity against Trypanosoma cruzi	2003	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12	The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
AID562498	Ratio of IC50 for Trypanosoma brucei gambiense K03048 to IC50 for Trypanosoma brucei gambiense STIB930	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID565597	Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 0.125 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.
AID1755301	Drug localization in nucleus of mouse MigA9 cells at 20 uM incubated for 2 hrs by TO-PRO-3/propidium iodide staining based by fluorescence microscopy	2019	Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3	Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model.
AID521061	Antimicrobial activity against Trypanosoma brucei brucei 427 bloodstream form assessed as inhibition of mitochondrial ATPase activity pretreated with oligomycin for 10 mins	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID1426425	Antiparasitic activity against drug-resistant Plasmodium falciparum Dd2 infected in erythrocytes assessed as growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID1146854	Antitrypanosomal activity against Trypanosoma rhodesiense infected in mouse assessed as increase in survival time by 30 days at 5 mg/kg relative to control	1977	Journal of medicinal chemistry, Sep, Volume: 20, Issue:9	Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles.
AID1062627	Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay	2014	Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1	Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
AID454678	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as survival days at 20 mg/kg, ip	2009	Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18	Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
AID1426426	Antiparasitic activity against drug-sensitive Plasmodium falciparum 3D7 infected in erythrocytes assessed as growth inhibition after 48 hrs by SYBR green 1 dye-based flow cytometry	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID212704	Toxicity at a dose of 0.03 umol/kg/day against Pneumocystis carinii in rats	1998	Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1	2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID551690	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1	2011	Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2	Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
AID1062626	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900	2014	Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1	Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
AID173670	In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 0.3 umol/kg/day	1998	Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20	Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID454673	Antiplasmodial activity against Plasmodium falciparum K1	2009	Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18	Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
AID212707	Toxicity at a dose of 0.3 umol/kg/day against Pneumocystis carinii in rats	1998	Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1	2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID243249	Ratio of maximum concentration bound and specificity sum for triplex DNA and quadruplex nucleic acids	2004	Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23	Structural selectivity of aromatic diamidines.
AID551691	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as parasitemia free host at 5 mg/kg, ip administered 2 days after post infection for 4 consecutive days measured up to 60 days	2011	Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2	Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
AID593438	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900	2011	Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7	Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.
AID432043	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
AID42676	In vitro minimum inhibitory concentration against Candida albicans.	2001	Journal of medicinal chemistry, May-24, Volume: 44, Issue:11	Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.
AID562494	Ratio of IC50 for Trypanosoma brucei gambiense K03048 to IC50 for wild-type Trypanosoma brucei rhodesiense STIB902	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID382523	Toxicity against immunosuppressed rat pneumocystis model at 13.3 umol/kg/day, iv	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1	Carbamate prodrugs of N-alkylfuramidines.
AID162071	The compound was tested in vivo against Pneumocystis carinii pneumonia (PCP) in the immunosuppressed rat model at oral dose of 39.8(umol/kg/day)	1999	Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19	Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan.
AID562496	Ratio of IC50 for Trypanosoma brucei gambiense STIB930 to IC50 for wild-type Trypanosoma brucei rhodesiense STIB904	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID481843	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900	2010	Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10	Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
AID1767953	Selectivity index, ratio of IC50 for cytotoxicity against rat L6 cells to IC50 for antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells
AID174177	The cysts/g of lung (% of control ) is calculated at a dose of 0.03 umol/kg /day against Pneumocystis carinii in rats	1998	Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1	2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID1128538	Antiproliferative activity against human HL60 cells with PML-RAR alpha translocation assessed as cell viability at 20 uM measured everyday for 3 days by CellTiter-Glo assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID322578	Cytotoxicity against rat L6 cells	2008	Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2	Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
AID551692	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as effect on survival days at 5 mg/kg, ip administered 2 days after post infection for 4 consecutive days measured up to 60 days	2011	Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2	Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
AID1426424	Antiparasitic activity against Leishmania spp.	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID1851333	Cytotoxicity against human HEK293-A cells	2022	Bioorganic & medicinal chemistry letters, 10-01, Volume: 73	Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking.
AID1062628	Antiplasmodial activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by li	2014	Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1	Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
AID1506647	Inhibition of PRMT1 (unknown origin) assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H4-20-Biotin at 10 uM pre-incubated for 3 mins before [3H]-SAM addition and measured after 15 mins by scintillation proximity as	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
AID765724	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900	2013	European journal of medicinal chemistry, Sep, Volume: 67	Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.
AID1851331	Inhibition of recombinant human TDP1 measured by real-time oligonucleotide biosensor assay	2022	Bioorganic & medicinal chemistry letters, 10-01, Volume: 73	Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking.
AID765718	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	2013	European journal of medicinal chemistry, Sep, Volume: 67	Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.
AID432046	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for chloroquine-resistant Plasmodium falciparum K1	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
AID1532281	Binding affinity to recombinant human Tdp1 (149 to 608 residues) expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.
AID38040	Drug concentration required to inhibit B16 cell growth by 50% after 72 hours of incubation	2002	Journal of medicinal chemistry, May-09, Volume: 45, Issue:10	Distribution of furamidine analogues in tumor cells: influence of the number of positive charges.
AID593439	Antiparasitic activity against Plasmodium falciparum K1	2011	Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7	Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.
AID765722	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for chloroquine-resistant Plasmodium falciparum K1	2013	European journal of medicinal chemistry, Sep, Volume: 67	Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.
AID322575	Binding affinity to poly(dA-dT) DNA	2008	Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2	Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
AID248239	In vitro antiprotozoal activity against Trypanosoma brucei rhodesiense strain STIB900	2005	Journal of medicinal chemistry, Aug-25, Volume: 48, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
AID562484	Antitrypanosomal activity against wild-type Trypanosoma brucei rhodesiense STIB900 by Alamar blue assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID1767950	Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 measured after 72 hrs by alamar blue dye based fluorimetry analysis
AID269491	Antiprotozoal activity against Plasmodium falciparum K1	2006	Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
AID562489	Antitrypanosomal activity against Trypanosoma brucei gambiense STIB930 by Alamar blue assay	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID1426422	Antitrypanosomal activity against Trypanosoma cruzi after 70 hrs by Alamar blue assay	2017	European journal of medicinal chemistry, Feb-15, Volume: 127	Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
AID340902	Antitrypanosomal activity against Trypanosoma brucei brucei S427 after 72 hrs	2007	Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8	Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID1685557	Inhibition of recombinant human His-tagged PRMT1 expressed in Escherichia coli BL21 (DE3) using biotin-labeled histone H4-20 as substrate incubated for 8 mins in presence of [3H]-SAM cofactor by scintillation proximity assay	2021	RSC medicinal chemistry, Jan-01, Volume: 12, Issue:1	Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases.
AID1062617	Trypanocidal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as mean survival days at 5 mg/kg, ip qd administered for 4 days	2014	Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1	Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
AID1767948	Cytotoxicity against rat L6 cells by Alamar blue assay
AID290097	Cytotoxicity against rat L6 cells by alamar blue assay	2007	European journal of medicinal chemistry, Apr, Volume: 42, Issue:4	Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
AID124386	No. of mice that survived T.b. rhodesiense infection and are parasite free for 60 days was determined at dose of 20 mg/kg by i.p. administration; 4 animals tested	2003	Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22	Synthesis and antiprotozoal activity of aza-analogues of furamidine.
AID212858	In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 0.03 umol/kg/day	1998	Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20	Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID565599	Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 0.0625 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.
AID562492	Ratio of IC50 for pentamidine-resistant Trypanosoma brucei rhodesiense STIB900 to IC50 for wild-type Trypanosoma brucei rhodesiense STIB900	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID162419	In vitro binding affinity towards Poly (dA-dT)2	2003	Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22	Synthesis and antiprotozoal activity of aza-analogues of furamidine.
AID564074	Antitrypanosomal activity against bloodstream forms of Trypanosoma cruzi Columbian after 24 hrs by light microscopy in presence of 50% mouse blood	2010	Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7	Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.
AID521058	Antimicrobial activity against Trypanosoma brucei brucei 427 bloodstream form assessed as inhibition of mitochondrial ATPase activity at 50 uM after 10 mins	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID432045	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
AID521049	Inhibition of respiration in Trypanosoma brucei brucei 427 bloodstream form mitochondria using glycerol-3-phosphate as substrate at 600 uM	2008	Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3	The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei.
AID1128533	Antiproliferative activity against human HEL cells harboring JAK2 V617F mutant assessed as cell viability at 20 uM measured everyday for 3 days by CellTiter-Glo assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID565603	Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 0.25 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days	2009	Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12	In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.
AID779109	Antiplasmodial activity against Plasmodium falciparum K1 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis	2013	Bioorganic & medicinal chemistry, Nov-01, Volume: 21, Issue:21	Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
AID247973	In vitro antiprotozoal activity for Plasmodium falciparum K1	2005	Journal of medicinal chemistry, Aug-25, Volume: 48, Issue:17	Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
AID1128529	Competitive inhibition of His6x-tagged recombinant PRMT1 (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]SAM and histone H4 (1 to 20) as substrate by double reciprocal plot analysis	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID208055	In vitro inhibitory activity against T. b. rhodesiense	2003	Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22	Synthesis and antiprotozoal activity of aza-analogues of furamidine.
AID1128534	Antiproliferative activity against human CMY cells harboring trisomy 21 assessed as cell viability at 20 uM measured everyday for 3 days by CellTiter-Glo assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
AID191637	Toxicity is evaluated according to a five-level scale ranging from 0 to 5+ at the specified oral dose of 39.8 (umol/kg/day)	1999	Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19	Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan.
AID173672	In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 2.7 umol/kg/day	1998	Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20	Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID382518	Antimicrobial activity against Pneumocystis carinii in immunosuppressed rat assessed as number of cysts/g of lung at 39.8 umol/kg/day, po relative to control	2008	European journal of medicinal chemistry, Jan, Volume: 43, Issue:1	Carbamate prodrugs of N-alkylfuramidines.
AID562497	Ratio of IC50 for Trypanosoma brucei brucei AT1KO to IC50 for Trypanosoma brucei brucei BS221	2009	Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10	New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
AID100423	Inhibitory activity against Leishmania donovani (macrophage); Not determined	2003	Bioorganic & medicinal chemistry letters, Jun-16, Volume: 13, Issue:12	The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
AID481845	Cytotoxicity against rat L6 cells	2010	Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10	Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
AID432044	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
AID249180	Apparent permeability determined across the Caco-2 cell monolayers in both apical (AP) to basolateral (BL) directions	2004	Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17	O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
AID286670	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	2007	Journal of medicinal chemistry, May-17, Volume: 50, Issue:10	Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
AID1062625	Selectivity index, ratio of IC50 for rat L6 cells to IC50 for chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells	2014	Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1	Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
AID1532280	Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc c-BHQ1)-3' as substrate measured every 1 min for 7 mins by fluorimetric method	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (3.70)	18.7374
1990's	10 (9.26)	18.2507
2000's	56 (51.85)	29.6817
2010's	31 (28.70)	24.3611
2020's	7 (6.48)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (0.93%)	5.53%
Reviews	3 (2.78%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	104 (96.30%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
adenine [no description available]	2.44	2	0	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
carbamates [no description available]	2.42	2	0	amino-acid anion
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	2.02	1	0	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
pyridine azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.	7.06	1	0	azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines	environmental contaminant; NMR chemical shift reference compound
thymine [no description available]	2.02	1	0	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite
17-octadecynoic acid octadec-17-ynoic acid : An acetylenic fatty acid that is octadecanoi acid (stearic acid) which has been doubly dehydrogenated at positions 17 and 18 to give the corresponding alkynoic acid.	2.03	1	0	acetylenic fatty acid; long-chain fatty acid; monounsaturated fatty acid; terminal acetylenic compound	EC 1.14.14.94 (leukotriene-B4 20-monooxygenase) inhibitor; EC 1.14.15.3 (alkane 1-monooxygenase) inhibitor; P450 inhibitor
tyrphostin 25 [no description available]	2.07	1	0	benzenetriol
arcaine arcaine: RN given refers to parent cpd; structure. 1,4-diguanidinobutane : A guanidine derivative consisting of butane having guanidino groups at the 1- and 4-positions.	2.11	1	0	guanidines
benzamidine benzamidine: RN given refers to parent cpd. benzamidine : A carboxamidine that is benzene carrying an amidino group.	6.93	1	0	benzenes; carboxamidine	serine protease inhibitor
diminazene Diminazene: An effective trypanocidal agent.. diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group.	3.4	7	0	carboxamidine; triazene derivative	antiparasitic agent; trypanocidal drug
camostat camostat : A benzoate ester resulting from the formal condensation of the carboxy group of 4-guanidinobenzoic acid with the hydroxy group of 2-(dimethylamino)-2-oxoethyl (4-hydroxyphenyl)acetate. It is a potent inhibitor of the human transmembrane protease serine 2 (TMPRSS2) and its mesylate salt is currently under investigation for its effectiveness in COVID-19 patients.	2.41	1	0	benzoate ester; carboxylic ester; diester; guanidines; tertiary carboxamide	anti-inflammatory agent; anticoronaviral agent; antifibrinolytic drug; antihypertensive agent; antineoplastic agent; antiviral agent; serine protease inhibitor
carbonyl cyanide m-chlorophenyl hydrazone Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.	2.04	1	0	hydrazone; monochlorobenzenes; nitrile	antibacterial agent; geroprotector; ionophore
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	3.76	10	0	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
dapi DAPI: RN given refers to parent cpd.	2.91	4	0	indoles	fluorochrome
ebastine [no description available]	2.03	1	0	organic molecular entity
fluconazole Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.	2	1	0	conazole antifungal drug; difluorobenzene; tertiary alcohol; triazole antifungal drug	environmental contaminant; P450 inhibitor; xenobiotic
gabexate Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.	7.41	1	0	benzoate ester
miltefosine miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.	2.44	2	0	phosphocholines; phospholipid	anti-inflammatory agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antiprotozoal drug; apoptosis inducer; immunomodulator; protein kinase inhibitor
mefloquine hydrochloride [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.	2.03	1	0	organofluorine compound; piperidines; quinolines; secondary alcohol
nafamostat nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic	7.9	2	0	benzoic acids; guanidines
netropsin Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.	2.98	4	0
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	11.22	43	0	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
oxophenylarsine oxophenylarsine: inhibits protein-tyrosine-phosphatase. phenylarsine oxide : An arsine oxide derived from phenylarsine.	2.03	1	0	arsine oxides	antineoplastic agent; apoptosis inducer; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
vorinostat Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.. vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).	2.15	1	0	dicarboxylic acid diamide; hydroxamic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	2.05	1	0	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
thymidine [no description available]	2.03	1	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
benzimidazole 1H-benzimidazole : The 1H-tautomer of benzimidazole.	2.06	1	0	benzimidazole; polycyclic heteroarene
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.67	3	0	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
framycetin Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.	2.07	1	0	aminoglycoside	allergen; antibacterial drug; Escherichia coli metabolite
isoxazoles Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.	2.03	1	0	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
melarsoprol Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.	3.56	8	0	triazines
podophyllotoxin Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.	3.16	5	0	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
thiophene-2-carboxylate thiophene-2-carboxylic acid : A thiophenecarboxylic acid in which the carboxy group is located at position 2.	1.93	1	0	thiophenecarboxylic acid
diphenylamine Diphenylamine: In humans it may be irritating to mucous membranes. Methemoglobinemia has been produced experimentally. In veterinary use, it is one of active ingredients in topical agents for prevention and treatment of screwworm infestation. An indicator in tests for nitrate poisoning.. diphenylamine : An aromatic amine containing two phenyl substituents. It has been used as a fungicide for the treatment of superficial scald in apples and pears, but is no longer approved for this purpose within the European Union.	2.05	1	0	aromatic amine; bridged diphenyl fungicide; secondary amino compound	antifungal agrochemical; antioxidant; carotogenesis inhibitor; EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor; ferroptosis inhibitor; radical scavenger
alpha-naphthoflavone alpha-naphthoflavone: inhibits P4501A1 and P4501A2; stimulates some activities of P4503A4. alpha-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).	2.43	2	0	extended flavonoid; naphtho-gamma-pyrone; organic heterotricyclic compound	aryl hydrocarbon receptor agonist; aryl hydrocarbon receptor antagonist; EC 1.14.14.14 (aromatase) inhibitor
Berberine chloride (TN) [no description available]	2.02	1	0	organic molecular entity
2'-deoxyadenosine 2'-deoxyformycin A: RN not in Chemline 9/85; RN and structure given in first source	2.03	1	0	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
ethidium bromide [no description available]	2.38	2	0	organic bromide salt	geroprotector; intercalator; trypanocidal drug
antimycin a [no description available]	2.04	1	0	benzamides; formamides; macrodiolide; phenols	antifungal agent; mitochondrial respiratory-chain inhibitor; piscicide
1,12-dodecamethylenediamine 1,12-dodecamethylenediamine: RN given refers to parent cpd. dodecane-1,12-diamine : An alkane-alpha,omega-diamine that is dodecane substituted by amino groups at positions 1 and 12.	2.11	1	0	alkane-alpha,omega-diamine
n-methylaspartate N-Methylaspartate: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).. N-methyl-D-aspartic acid : An aspartic acid derivative having an N-methyl substituent and D-configuration.	2.6	1	0	amino dicarboxylic acid; D-alpha-amino acid; D-aspartic acid derivative; secondary amino compound	neurotransmitter agent
coralyne [no description available]	2.02	1	0
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.11	1	0	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
daunorubicin Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.	1.99	1	0	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite
benzonidazole benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.	2.74	3	0	C-nitro compound; imidazoles; monocarboxylic acid amide	antiprotozoal drug
4',6-bis(2'imidazolinyl-4',5'-h)-2-phenylindole 4',6-bis(2'imidazolinyl-4',5'-H)-2-phenylindole: used to produce distinct fluorescent bands in human chromosomes; structure	1.95	1	0
1,2-di(5-amidino-2-benzofuranyl)ethane 1,2-di(5-amidino-2-benzofuranyl)ethane: preferential inhibitor of bovine factor Xa; structure given in first source	1.95	1	0
topotecan Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.. topotecan : A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.	2.21	1	0	pyranoindolizinoquinoline	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor
irinotecan [no description available]	7.11	1	0	carbamate ester; delta-lactone; N-acylpiperidine; pyranoindolizinoquinoline; ring assembly; tertiary alcohol; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	2.03	1	0	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
phenamidine phenamidine: RN given refers to parent cpd; structure	2.15	1	0
propamidine propamidine: structure given in first source. propamidine : A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.	2.8	3	0	aromatic ether; guanidines; polyether	antimicrobial agent; antiseptic drug
hexamidine hexamidine : A polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol.	2.15	1	0	aromatic ether; guanidines; polyether	antimicrobial agent; antiseptic drug
melarsomine melarsomine: structure given in first source	2.05	1	0
salicylhydroxamic acid [no description available]	2.04	1	0	hydroxamic acid; phenols	antibacterial drug; EC 1.11.2.2 (myeloperoxidase) inhibitor; EC 3.5.1.5 (urease) inhibitor; trypanocidal drug
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	2.06	1	0	1,2,3-triazole
artemether Artemether: An artemisinin derivative that is used in the treatment of MALARIA.. artemether : An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.	2.03	1	0	artemisinin derivative; cyclic acetal; organic peroxide; semisynthetic derivative; sesquiterpenoid	antimalarial
2,5-diphenylfuran [no description available]	2	1	0	diphenylfuran
atovaquone Atovaquone: A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.. atovaquone : A naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position.	2.04	1	0	hydroxy-1,2-naphthoquinone
artesunic acid [no description available]	2.03	1	0
piperaquine piperaquine : An aminoquinoline that is 1,3-di(piperazin-1-yl)propane in which the nitrogen at position 4 of each of the piperazine moieties is replaced by a 7-chloroquinolin-4-yl group.	2.04	1	0	aminoquinoline; N-arylpiperazine; organochlorine compound	antimalarial
butamidine butamidine: RN refers to HCl; structure in first source	2.53	2	0
3-methoxy-7h-8-methyl-11-((3'-amino)propylamino)benzo(e)pyrido(4,3-b)indole 3-methoxy-7H-8-methyl-11-((3'-amino)propylamino)benzo(e)pyrido(4,3-b)indole: a benzo(e)pyridoindole derivative	2.02	1	0
2-(4-amidinophenyl)-1-benzofuran-5-carboxamidine 2-(4-amidinophenyl)-1-benzofuran-5-carboxamidine: structure given in first source	1.95	1	0
nsc 88915 4-pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate): a tyrosyl-DNA phosphodiesterase inhibitor; structure in first source	2.07	1	0
leupeptins Leupeptins: A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.	2.02	1	0
puromycin [no description available]	2.13	1	0	puromycins	antiinfective agent; antimicrobial agent; antineoplastic agent; EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor; EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor; nucleoside antibiotic; protein synthesis inhibitor
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	2.03	1	0	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.17	1	0	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
db 244 [no description available]	2.93	4	0
furimidazoline furimidazoline: structure in first source	3.12	5	0
db293 DB293: structure in first source	2.96	4	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.	2.02	1	0	amino aldehyde; carbamate ester; tripeptide	proteasome inhibitor
(+)-usnic acid [no description available]	2.21	1	0	usnic acid
sesquiterpenes [no description available]	2.03	1	0
ag-213 tyrphostin 47: inhibits protein-tyrosine kinase activity of EGF-R both in vitro and in living cells;	2.07	1	0
n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine HET0016: 20-Hydroxyeicosatetraenoic Acid synthesis inhibitor	2.03	1	0	toluenes
valinomycin Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.. valinomycin : A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.	2.04	1	0	cyclodepsipeptide; macrocycle	antimicrobial agent; antiviral agent; bacterial metabolite; potassium ionophore
rhodamine 123 Rhodamine 123: A fluorescent probe with low toxicity which is a potent substrate for ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 and the bacterial multidrug efflux transporter. It is used to assess mitochondrial bioenergetics in living cells and to measure the efflux activity of ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 in both normal and malignant cells. (Leukemia 1997;11(7):1124-30). rhodamine 123(1+) : A cationic fluorescent dye derived from 9-phenylxanthene.	2.04	1	0	organic cation; xanthene dye	fluorochrome
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.08	1	0	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
20-hydroxy-5,8,11,14-eicosatetraenoic acid 20-hydroxy-5,8,11,14-eicosatetraenoic acid: stimulator of renal sodium, potassium atpase; RN given is for the (all-Z) isomer. 20-HETE : A HETE that consists of arachidonic acid bearing a hydroxy substituent at position 20.	2.03	1	0	HETE; hydroxy monocarboxylic acid	human metabolite; mouse metabolite
diminazene aceturate diminazene diaceturate : An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine.	2.41	2	0	N-acetylglycinate salt	antiparasitic agent; trypanocidal drug
hydroxystilbamidine hydroxystilbamidine: minor descriptor (63-86); on-line & INDEX MEDICUS search STILBAMIDINES (66-86); RN given refers to parent cpd	1.95	1	0
ag 99 tyrphostin A46: epidermal growth factor-urogastrone receptor antagonist	2.07	1	0
ag-490 [no description available]	2.07	1	0	catechols; enamide; monocarboxylic acid amide; nitrile; secondary carboxamide	anti-inflammatory agent; antioxidant; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; geroprotector; STAT3 inhibitor
ag 30 AG 30: structure given in first source; do not confuse with AG-30 antimicrobial peptide	2.07	1	0
stilbamidine stilbamidine: RN given refers to parent cpd	3.11	5	0
mbx 1090 [no description available]	2.31	1	0
pafuramidine pafuramidine: a prodrug of furamidine	7.51	23	1
db 820 [no description available]	3.55	8	0
arterolane arterolane: a trioxolane with antimalarial activity; structure in first source. arterolane : An oxaspiro compound that is dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.1(3,7)]decane] substituted by a 2-[(2-amino-2-methylpropyl)amino]-2-oxoethyl group at position 4s. Its maleic acid salt is used as an antimalarial drug in combination with piperaquine.	2.44	2	0
piperidines Piperidines: A family of hexahydropyridines.	2.03	1	0
oligomycin a [no description available]	2.04	1	0	antibiotic antifungal agent; diketone; oligomycin; pentol	antineoplastic agent; EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor; nematicide
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2	1	0	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor
db 766 [no description available]	2.05	1	0

Condition	Relationship Strength	Studies	Trials
Experimental Leukemia [description not available]	1.95	1	0
P carinii Pneumonia [description not available]	2.92	4	0
Pneumonia, Pneumocystis A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.	2.92	4	0
African Sleeping Sickness [description not available]	5.15	17	0
Trypanosomiasis, African A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.	5.15	17	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.84	11	0
Cyst [description not available]	2.04	1	0
Plasmodium falciparum Malaria [description not available]	5.26	4	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	5.26	4	1
Trypanosomiasis Infection with protozoa of the genus TRYPANOSOMA.	2.47	2	0
American Trypanosomiasis [description not available]	3.88	4	0
Chagas Disease Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.	3.88	4	0
Leucocythaemia [description not available]	2.54	2	0
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2.54	2	0
Cancer of Lung [description not available]	2.21	1	0
Experimental Neoplasms [description not available]	2.21	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	2.21	1	0
Degenerative Diseases, Central Nervous System [description not available]	2.41	1	0
Neurodegenerative Diseases Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.	2.41	1	0
Congenital Myotonic Dystrophy [description not available]	2.17	1	0
Myotonic Dystrophy Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLECTUAL DISABILITY may also occur. Abnormal TRINUCLEOTIDE REPEAT EXPANSION in the 3' UNTRANSLATED REGIONS of DMPK PROTEIN gene is associated with Myotonic Dystrophy 1. DNA REPEAT EXPANSION of zinc finger protein-9 gene intron is associated with Myotonic Dystrophy 2.	7.17	1	0
Glomerulonephritis, Lupus [description not available]	2.11	1	0
Lupus Nephritis Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).	7.11	1	0
Infections, Plasmodium [description not available]	2.06	1	0
Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	7.06	1	0
Adenocarcinoma, Basal Cell [description not available]	2.01	1	0
B16 Melanoma [description not available]	2.01	1	0
Benign Neoplasms [description not available]	2.01	1	0
Cancer of Prostate [description not available]	2.01	1	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.01	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.01	1	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.01	1	0
Parasitemia The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)	2.03	1	0
Plasmodium vivax Malaria [description not available]	2.03	1	0
Malaria, Vivax Malaria caused by PLASMODIUM VIVAX. This form of malaria is less severe than MALARIA, FALCIPARUM, but there is a higher probability for relapses to occur. Febrile paroxysms often occur every other day.	2.03	1	0
Leishmania Infection [description not available]	2.94	1	0
Leishmaniasis A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).	2.94	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.03	1	0

furamidine

Description

Cross-References

Synonyms (44)

Research Excerpts

Overview

Pharmacokinetics

Bioavailability

Dosage Studied

Protein Targets (25)

Potency Measurements

Inhibition Measurements

Other Measurements

Biological Processes (76)

Molecular Functions (56)

Ceullar Components (16)

Bioassays (274)

Research

Studies (108)

Market Indicators

Research Demand Index: 29.79

Study Types

furamidine

Description

Cross-References

Synonyms (44)

Research Excerpts

Overview

Pharmacokinetics

Bioavailability

Dosage Studied

Protein Targets (25)

Potency Measurements

Inhibition Measurements

Other Measurements

Biological Processes (76)

Molecular Functions (56)

Ceullar Components (16)

Bioassays (274)

Research

Studies (108)

Market Indicators

Research Demand Index: 29.79

Study Types

Related Drugs (95)

Related Conditions (38)