Page last updated: 2024-09-27

Extensively Drug-Resistant Tuberculosis

Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.

Synonyms(5)

Synonym
Extremely Drug-Resistant Tuberculosis
Tuberculosis, Extensively Drug-Resistant
Extensively Drug-Resistant Tuberculosis
Tuberculosis, Extremely Drug-Resistant
XDR-TB

Research

Studies (472)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's41 (8.69)18.1394
2010's334 (70.76)28.8240
2020's97 (20.55)9.53
DrugIndicatedRelationship StrengthStudiesTrials
coumarin0low10
cytosine0low10
pyrazinamide0low270
pyrazinoic acid0low20
pyridoxine0low10
thymine0low10
arotinolol0low10
verapamil0low20
chlorpromazine0low10
ciprofloxacin0low40
clofazimine0medium252
disulfiram0low10
fluconazole0low10
isoniazid0low830
ofloxacin0low360
aminosalicylic acid0medium131
gatifloxacin0low20
thioridazine0low180
prednisolone0low10
kanamycin a0low360
carbostyril0low10
cycloserine0low80
tubercidin0low10
xanthenes0low10
phenothiazine0low10
thiophenes0low10
ditiocarb0low10
adamantane0low40
isoxazoles0low20
oxazoles0medium531
alpha-aminopyridine0low10
azomycin0medium672
resazurin0low10
malachite green0low10
c.i. 425100low10
ethambutol0low260
ethidium bromide0low10
pasiniazide0low10
streptomycin0low150
amoxicillin0low10
sisomicin0low10
amikacin0low310
mefloquine0low10
nitazoxanide0low10
sparfloxacin0low20
efavirenz0medium11
cephalosporin c0low10
terizidone0low10
triazoles0low10
fluorodeoxyglucose f180low10
oxazolidin-2-one0medium464
clarithromycin0low30
lopinavir0low10
glycidyl nitrate0low10
imipenem, anhydrous0low50
carbapenems0low70
beta-lactams0low30
levofloxacin0low130
ertapenem0low30
moxifloxacin0low200
anidulafungin0low10
azd25630low20
trimethoprim, sulfamethoxazole drug combination0low20
ritonavir0low10
meropenem0low150
linezolid0medium829
pa 8240medium181
u 1004800low30
prothionamide0low30
ethionamide0low110
carbonyl 3-chlorophenylhydrazone0low10
tolcapone0low10
sq 1090low50
clavulanic acid0low120
entacapone0low10
bedaquiline0medium843
cysteine0low10
opc-676830medium472
tebipenem0low10
amoxicillin-potassium clavulanate combination0low40
oxadiazoles0low20
cyclomarin a0low10
rifamycins0low20
clove0low10
nad0low10
oligonucleotides0low10
acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ilys-prolyl-alaninamide0low10
btz 0430low10
achn 4900low10
glycolipids0low10
piperidines0low20
colistin0low20
sulfolipid i0low10
heme0low10
tetracycline0low10
minocycline0low10
warfarin0low20
lymecycline0low10
pbtz1690low10
agar0low10
nitrophenols0low10
cord factors0low10
exudates0low10
trehalose monomycolate0low10
viomycin0low10
rifampin0low990
rifapentine0low30
azilsartan0low10
amg5310low10

Protein Targets (892)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Gonadotropin-releasing hormone receptor0112
AR protein240024
retinoic acid nuclear receptor alpha variant 1180018
estrogen nuclear receptor alpha340034
thyroid stimulating hormone receptor9009
thyroid hormone receptor beta isoform 2190019
Voltage-dependent calcium channel gamma-2 subunit100010
Heat shock protein HSP 90-alpha0011
Botulinum neurotoxin type A 0101
Neutrophil cytosol factor 10202
Glutamate receptor 2100010
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0101
Nitric oxide synthase, brain 0101
Nitric oxide synthase, inducible0101
Kappa-type opioid receptor0215
Phosphatidylinositol 4-kinase alpha0101
Mu-type opioid receptor0011
Tyrosine-protein kinase 0011
Phosphatidylinositol 4-kinase type 2-beta0101
Phosphatidylinositol 4-kinase type 2-alpha0101
Phosphatidylinositol 4-kinase beta0101
Luciferase9009
acetylcholinesterase100010
hypoxia-inducible factor 1 alpha subunit100010
RAR-related orphan receptor gamma180018
estrogen receptor 2 (ER beta)120012
progesterone receptor160016
cytochrome P450 family 3 subfamily A polypeptide 4210021
EWS/FLI fusion protein200020
farnesoid X nuclear receptor140014
G180018
cytochrome P450 2D6130013
peroxisome proliferator-activated receptor delta150015
peroxisome proliferator activated receptor gamma160016
vitamin D (1,25- dihydroxyvitamin D3) receptor140014
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a8008
v-jun sarcoma virus 17 oncogene homolog (avian)9009
Histone H2A.x110011
heat shock protein beta-18008
nuclear factor erythroid 2-related factor 2 isoform 1180018
Solute carrier family 22 member 1 0505
Solute carrier organic anion transporter family member 2B1 0505
Interferon beta210021
HLA class I histocompatibility antigen, B alpha chain 180018
Replicase polyprotein 1ab0628
Replicase polyprotein 1ab011314
Thrombopoietin receptor0011
Potassium voltage-gated channel subfamily H member 2023127
Sodium channel protein type 5 subunit alpha0505
Inositol hexakisphosphate kinase 1180018
Solute carrier organic anion transporter family member 1B30607
Potassium voltage-gated channel subfamily D member 30101
Broad substrate specificity ATP-binding cassette transporter ABCG2010111
Solute carrier organic anion transporter family member 1B10809
cytochrome P450 2C9, partial180018
peripheral myelin protein 22110011
histone acetyltransferase KAT2A isoform 1120012
lamin isoform A-delta10160016
ATP-binding cassette sub-family C member 3028028
Multidrug resistance-associated protein 4028028
Bile salt export pump039039
Canalicular multispecific organic anion transporter 1027027
Aminoglycoside 3'-phosphotransferase 0001
ATP-dependent phosphofructokinase5005
Chain A, 2-oxoglutarate Oxygenase130013
Microtubule-associated protein tau100010
thioredoxin glutathione reductase2002
Smad39009
euchromatic histone-lysine N-methyltransferase 2200020
microphthalmia-associated transcription factor isoform 90101
Carbonic anhydrase 10506
Carbonic anhydrase 20506
Tyrosine-protein phosphatase non-receptor type 10011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Chain A, Beta-lactamase6006
Beta-lactamase 0102
Beta-lactamase 0103
Beta-lactamase 0003
Beta-lactamase 0103
apical membrane antigen 1, AMA14004
Beta-lactamase 0001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)8008
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
DNA polymerase kappa isoform 17007
Bile salt export pump012012
Beta-lactamase SHV-10102
Beta-lactamase SHV-10205
Cytochrome P450 2C9 014015
Beta-lactamase0104
Solute carrier family 15 member 10101
Solute carrier family 15 member 10101
Cytochrome P450 2J20505
B2 metallo-beta-lactamase 0003
Solute carrier family 15 member 20101
Beta-lactamase 0102
Beta-lactamase 0102
Solute carrier family 15 member 20101
Beta-lactamase 0102
Beta-lactamase 0002
Cytochrome P450 1A2011113
Cytochrome P450 3A4015017
Cytochrome P450 2C80404
Cytochrome P450 2D609111
Cytochrome P450 2B60315
Cytochrome P450 2C1909010
Spike glycoprotein142218
ATP synthase subunit c0011
ATP synthase subunit c 0101
Sigma intracellular receptor 20101
TDP1 protein240024
GLI family zinc finger 3230023
glucocorticoid receptor [Homo sapiens]240024
retinoid X nuclear receptor alpha150015
estrogen-related nuclear receptor alpha190019
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
nuclear receptor subfamily 1, group I, member 25005
Cellular tumor antigen p53150015
ATPase family AAA domain-containing protein 5110011
Ataxin-2130013
Chain A, Putative fructose-1,6-bisphosphate aldolase6006
Chain A, serum paraoxonase0101
nuclear receptor ROR-gamma isoform 1120012
Carbonic anhydrase 120203
Carbonic anhydrase 30202
Carbonic anhydrase 40202
Carbonic anhydrase 60202
Carbonic anhydrase 5A, mitochondrial0202
Carbonic anhydrase 70202
Carbonic anhydrase 90203
Carbonic anhydrase 130202
Poly [ADP-ribose] polymerase tankyrase-20101
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Proteasome subunit beta type-110001
thioredoxin reductase8008
phosphopantetheinyl transferase100010
ATAD5 protein, partial3003
Fumarate hydratase6006
USP1 protein, partial110011
NFKB1 protein, partial2002
Thrombopoietin2002
caspase 7, apoptosis-related cysteine protease6006
nuclear receptor subfamily 1, group I, member 3130013
NADPH oxidase 10202
pregnane X nuclear receptor170017
polyprotein6006
67.9K protein7007
Snq2p0003
caspase-36006
IDH16006
Adenylate cyclase type 1 0202
Caspase-74004
Spike glycoprotein0224
Replicase polyprotein 1ab0325
cytochrome P450 2D6 isoform 13003
cellular tumor antigen p53 isoform a4004
D(1A) dopamine receptor3003
vitamin D3 receptor isoform VDRA120012
chromobox protein homolog 1130013
potassium voltage-gated channel subfamily H member 2 isoform d110011
caspase-34004
histone deacetylase 9 isoform 35005
mitogen-activated protein kinase 19009
atrial natriuretic peptide receptor 2 precursor3003
ras-related protein Rab-9A3003
serine/threonine-protein kinase mTOR isoform 13003
geminin170017
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 19009
M-phase phosphoprotein 84004
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)6006
Gamma-aminobutyric acid receptor subunit pi93012
Proteasome subunit alpha type-70001
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Transmembrane protease serine 20224
Glutamate receptor ionotropic, NMDA 2D0101
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0606
5-hydroxytryptamine receptor 40808
Potassium channel subfamily K member 20101
Epidermal growth factor receptor0202
Albumin01611
Albumin0033
Major prion protein0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Major prion protein0011
Integrin beta-33003
Tyrosine-protein kinase Fyn0202
Procathepsin L0224
Aldo-keto reductase family 1 member B10808
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M40404
ATP-dependent translocase ABCB108118
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Integrin alpha-IIb3003
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0808
Replicase polyprotein 1a0224
Replicase polyprotein 1ab0224
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10404
Polyunsaturated fatty acid lipoxygenase ALOX150404
Angiotensin-converting enzyme0606
D(2) dopamine receptor0607
5-hydroxytryptamine receptor 2A0202
Gamma-aminobutyric acid receptor subunit beta-193012
Alpha-1B adrenergic receptor010010
Sphingomyelin phosphodiesterase0101
Alpha-2B adrenergic receptor0606
Gamma-aminobutyric acid receptor subunit delta93012
Gamma-aminobutyric acid receptor subunit gamma-293012
Alpha-2C adrenergic receptor0404
D0303
D(3) dopamine receptor0303
5-hydroxytryptamine receptor 1A0618
Alpha-2B adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit alpha-593012
Gamma-aminobutyric acid receptor subunit alpha-393012
D(2) dopamine receptor0101
Muscarinic acetylcholine receptor M30404
Proteasome subunit beta type-10001
Substance-K receptor0404
D(1A) dopamine receptor0607
D(4) dopamine receptor0607
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0303
UDP-glucuronosyltransferase 1A40102
Alpha-2A adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit gamma-193012
Gamma-aminobutyric acid receptor subunit alpha-293012
Alpha-1D adrenergic receptor0606
Sodium-dependent noradrenaline transporter 0808
Sodium-dependent dopamine transporter0303
Histamine H2 receptor0606
Alpha-1D adrenergic receptor0404
D(1B) dopamine receptor0303
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 2C0808
Gamma-aminobutyric acid receptor subunit alpha-493012
Gamma-aminobutyric acid receptor subunit gamma-393012
5-hydroxytryptamine receptor 1B0606
Trypanothione reductase0202
Gamma-aminobutyric acid receptor subunit alpha-693012
D(4) dopamine receptor0303
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0112
Sodium-dependent serotonin transporter0606
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0101
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0306
5-hydroxytryptamine receptor 70202
Histamine H1 receptor0404
Mu-type opioid receptor0606
Glutamate receptor ionotropic, NMDA 1 0213
D(3) dopamine receptor0809
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor0202
Kappa-type opioid receptor0808
5-hydroxytryptamine receptor 2B0808
Melanocortin receptor 30202
Alpha-1A adrenergic receptor010010
Histamine H2 receptor6006
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60606
5-hydroxytryptamine receptor 70202
Gastrin/cholecystokinin type B receptor0101
Proteasome subunit alpha type-60023
D(2) dopamine receptor0506
Calmodulin 0112
Gamma-aminobutyric acid receptor subunit alpha-193012
Gamma-aminobutyric acid receptor subunit beta-393012
Gamma-aminobutyric acid receptor subunit beta-293012
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0606
Sodium-dependent dopamine transporter 0808
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0204
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0606
Voltage-dependent L-type calcium channel subunit alpha-1C0606
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 9 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2D0213
Nuclear receptor subfamily 3 group C member 3 0606
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0213
GABA theta subunit93012
D0101
Sodium channel protein type 2 subunit alpha0101
Proteasome subunit beta type-70001
Sigma non-opioid intracellular receptor 10404
Angiotensin-converting enzyme 2 0224
Gamma-aminobutyric acid receptor subunit epsilon93012
Sodium channel protein type 3 subunit alpha0101
Glutamate receptor ionotropic, NMDA 3A0213
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
Chain A, HADH2 protein9009
Chain B, HADH2 protein9009
Chain A, Cruzipain5005
aldehyde dehydrogenase 1 family, member A1120012
cytochrome P450 2C9 precursor3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0204
DNA gyrase subunit A06010
DNA gyrase subunit B06010
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0103
DNA topoisomerase 4 subunit A0305
DNA topoisomerase 2-alpha0106
DNA gyrase subunit A0204
Multidrug resistance protein MdtK0022
DNA gyrase subunit B0507
DNA gyrase subunit A0709
Enoyl-[acyl-carrier-protein] reductase [NADH]0207
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0202
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 12002
streptokinase A precursor0077
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0102
Beta-lactamase 0202
Beta-lactamase 0101
Beta-lactamase 0102
Beta-lactamase0101
Beta-lactamase0202
Beta-lactamase0103
Neutrophil elastase0101
Beta-lactamase OXA-10101
Beta-lactamase TEM0205
Beta-lactamase0101
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0101
Class D beta-lactamase0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0103
Metallo-b-lactamase 0004
Beta-lactamase 0103
Carbapenem-hydrolyzing beta-lactamase KPC0204
Beta-lactamase class B VIM-2 0015
Chain A, JmjC domain-containing histone demethylation protein 3A6006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
transcriptional regulator ERG isoform 33003
mitogen-activated protein kinase kinase kinase kinase 2 isoform 10011
eyes absent homolog 2 isoform a1001
mitogen-activated protein kinase kinase kinase 3 isoform 10011
Estrogen receptor0022
Spike glycoprotein0011
Cruzipain0101
C-terminal-binding protein 11001
Estrogen receptor beta0022
pregnane X receptor2002
GALC protein2002
thyroid hormone receptor beta isoform a4004
glycogen synthase kinase-3 alpha0001
muscleblind-like protein 1 isoform 14004
Exportin-10101
Glyceraldehyde-3-phosphate dehydrogenase0101
NAD-dependent histone deacetylase SIR20103
Cytochrome P450 2A60102
Aldo-keto reductase family 1 member B10202
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
Amine oxidase [flavin-containing] B0202
Cytochrome P450 2A50001
Amine oxidase [flavin-containing] A 0101
Acetylcholinesterase0101
Acetylcholinesterase0101
UDP-glucuronosyltransferase 1A1 0202
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal0101
Substance-P receptor0001
UDP-glucuronosyltransferase 2B10 0101
Quinone oxidoreductase0001
Beta-secretase 10101
Sorbitol dehydrogenase0101
Induced myeloid leukemia cell differentiation protein Mcl-10202
Zn finger protein 0101
Dihydroorotate dehydrogenase 0101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
thyroid stimulating hormone receptor7007
regulator of G-protein signaling 44004
Bloom syndrome protein isoform 12002
D-alanine--D-alanine ligase0101
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 0101
Proton-coupled amino acid transporter 10101
Deoxycytidine kinase0001
Chain A, Ferritin light chain4004
15-lipoxygenase, partial5005
SMAD family member 28008
GLS protein7007
PPM1D protein5005
SMAD family member 38008
hypothetical protein, conserved2002
nonstructural protein 11001
pyruvate kinase2002
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
LacZ protein (plasmid)0011
aryl hydrocarbon receptor9009
activating transcription factor 66006
thyrotropin-releasing hormone receptor2002
beta-2 adrenergic receptor1001
peripheral myelin protein 22 isoform 11001
type-1 angiotensin II receptor0101
polyunsaturated fatty acid lipoxygenase ALOX122002
cytochrome P450 2C19 precursor1001
atrial natriuretic peptide receptor 1 precursor2002
runt-related transcription factor 1 isoform AML1b2002
perilipin-50101
glucose-6-phosphate 1-dehydrogenase isoform b0101
perilipin-10101
core-binding factor subunit beta isoform 22002
huntingtin isoform 27007
polypyrimidine tract-binding protein 1 isoform a1001
flap endonuclease 14004
serine/threonine-protein kinase PLK11001
apelin receptor0101
heat shock protein HSP 90-alpha isoform 20103
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Vpr3003
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
pyruvate kinase PKM isoform b1001
neuropeptide S receptor isoform A4004
Fatty-acid amide hydrolase 10101
Transient receptor potential cation channel subfamily A member 10011
Carbamate kinase0101
Retinal dehydrogenase 10101
Amyloid-beta precursor protein1001
Aldehyde dehydrogenase, mitochondrial0101
Ornithine decarboxylase1001
Fructose-1,6-bisphosphatase 10101
Adenosine receptor A30404
Amine oxidase [flavin-containing] A0606
C-X-C chemokine receptor type 20202
Mitogen-activated protein kinase 3 0101
Protein-lysine 6-oxidase0101
Lysine-specific demethylase 5A0101
Caspase-10202
Alpha-synuclein1405
C-C chemokine receptor type 20202
C-C chemokine receptor type 40202
C-C chemokine receptor type 50202
Gasdermin-D0202
Lysyl oxidase homolog 30101
Inositol monophosphatase 11001
TAR DNA-binding protein 432002
NACHT, LRR and PYD domains-containing protein 3 0101
Lysyl oxidase homolog 40101
Histone-lysine N-methyltransferase EHMT20101
Monoglyceride lipase0101
Gasdermin-D0202
Histone-lysine N-methyltransferase EHMT10101
Lysyl oxidase homolog 20101
heat shock protein 90, putative0002
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
Chain A, POL POLYPROTEIN0101
Chain A, POL POLYPROTEIN0101
Chain B, POL POLYPROTEIN0101
Chain A, POL POLYPROTEIN0101
Chain B, POL POLYPROTEIN0101
Chain A, Pol Polyprotein0101
Chain B, Pol Polyprotein0101
Prothrombin 0101
Gag-Pol polyprotein0303
Gag-Pol polyprotein0303
Acetylcholinesterase0001
Cannabinoid receptor 10202
Microsomal triglyceride transfer protein large subunit0101
Disintegrin and metalloproteinase domain-containing protein 170101
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 0101
Reverse transcriptase/RNaseH 0319
Protease 0429
Fructose-1,6-bisphosphatase 1 0001
Reverse transcriptase 0112
Cholesterol 24-hydroxylase0011
UDP-glucuronosyltransferase 1A90002
Catechol O-methyltransferase0303
Catechol O-methyltransferase0202
Adenosine receptor A2a0303
UDP-glucuronosyltransferase 2B150002
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Metallo-beta-lactamase VIM-19 0003
Beta-lactamase 0003
Pantothenate synthetase0202
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
glp-1 receptor, partial3003
WRN1001
Microphthalmia-associated transcription factor0001
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
luciferase1001
alpha-galactosidase2002
FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)0001
tumor necrosis factor1001
histone-lysine N-methyltransferase NSD2 isoform 10001
nuclear factor erythroid 2-related factor 2 isoform 25005
polyadenylate-binding protein 10101
nuclear factor NF-kappa-B p105 subunit isoform 11001
caspase-1 isoform alpha precursor1001
Telomerase reverse transcriptase0101
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0202
Platelet-activating factor receptor1001
Caspase-71001
10 kDa heat shock protein, mitochondrial0202
Guanine nucleotide-binding protein G2002
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
putative polyprotein0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor5005
DNA polymerase beta4004
Polyphenol oxidase 20305
Nuclear receptor ROR-gamma2002
Chain A, BCL-2-RELATED PROTEIN A10011
unnamed protein product0101
bcl-2-like protein 11 isoform 10011
Histone deacetylase 30101
Rap guanine nucleotide exchange factor 33003
Chymotrypsinogen A0101
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Heme oxygenase 1 0101
ATP-dependent translocase ABCB10303
Lanosterol 14-alpha demethylase0112
Aromatase0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
ATP-dependent translocase ABCB10304
Heme oxygenase 20101
Malate dehydrogenase, cytoplasmic0101
Histone deacetylase 40101
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
Histone deacetylase 10101
Lanosterol 14-alpha demethylase0213
Sterol 14-alpha demethylase0011
Sterol 14-alpha demethylase0112
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
14-alpha sterol demethylase 0011
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
likely tRNA 2'-phosphotransferase0101
endonuclease IV1001
Beta-lactamase 0101
Beta-lactamase 0002
arylsulfatase A4004
Metallo-beta-lactamase type 20013
Metallo-beta-lactamase VIM-11 0002
Metallo-beta-lactamase VIM-20002
Metallo-beta-lactamase0002
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-130002
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0001
Beta-lactamase 0002
Beta-lactamase 0002
Metallo-beta-lactamase0002
Beta-lactamase 0002
Beta-lactamase 0013
Beta-lactamase 0001
Beta-lactamase IMP-1 0002
BlaVIM-1 0002
Histamine H3 receptor0002
Beta-lactamase 0002
Beta-lactamase VIM-1 0002
bromodomain adjacent to zinc finger domain 2B5005
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
N-glycosylase/DNA lyase0101
Myeloperoxidase0101
Formamidopyrimidine-DNA glycosylase0101
Macrophage migration inhibitory factor0101
Endonuclease III-like protein 10101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0101
Endonuclease 8-like 10101
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
CAAX prenyl protease 2 isoform 20001
Tubulin beta-4A chain0101
Tubulin beta chain0101
Tubulin alpha-3C chain0101
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
Fatty-acid amide hydrolase 10202
DNA primase0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Multidrug and toxin extrusion protein 10202
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
30S ribosomal protein S60202
30S ribosomal protein S70202
50S ribosomal protein L150202
50S ribosomal protein L100202
50S ribosomal protein L110202
50S ribosomal protein L7/L120202
50S ribosomal protein L190202
50S ribosomal protein L10202
50S ribosomal protein L200202
50S ribosomal protein L270202
50S ribosomal protein L280202
50S ribosomal protein L290202
50S ribosomal protein L310202
50S ribosomal protein L31 type B0202
50S ribosomal protein L320202
50S ribosomal protein L330202
50S ribosomal protein L340202
50S ribosomal protein L350202
50S ribosomal protein L360202
30S ribosomal protein S100202
30S ribosomal protein S110202
30S ribosomal protein S120202
30S ribosomal protein S130202
30S ribosomal protein S160202
30S ribosomal protein S180202
30S ribosomal protein S190202
30S ribosomal protein S200202
30S ribosomal protein S20202
30S ribosomal protein S30202
30S ribosomal protein S40202
30S ribosomal protein S50202
30S ribosomal protein S80202
30S ribosomal protein S90202
50S ribosomal protein L130202
50S ribosomal protein L140202
50S ribosomal protein L160202
50S ribosomal protein L230202
30S ribosomal protein S150202
50S ribosomal protein L170202
50S ribosomal protein L210202
50S ribosomal protein L300202
50S ribosomal protein L60202
30S ribosomal protein S140202
30S ribosomal protein S170202
30S ribosomal protein S10202
50S ribosomal protein L180202
Prostaglandin G/H synthase 10202
Amine oxidase [flavin-containing] B0303
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial0101
50S ribosomal protein L20202
50S ribosomal protein L30202
50S ribosomal protein L240202
50S ribosomal protein L40202
50S ribosomal protein L220202
50S ribosomal protein L50202
30S ribosomal protein S210202
50S ribosomal protein L250202
50S ribosomal protein L36 20202
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Renin0101
Chain A, protease0101
Chain B, protease0101
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, PROTEASE RETROPEPSIN0101
Chain B, PROTEASE RETROPEPSIN0101
Chain A, Protease Retropepsin0101
Chain B, Protease Retropepsin0101
Chain A, Protease Retropepsin0101
Chain B, Protease Retropepsin0101
Gag-Pol polyprotein0202
Gag-Pol polyprotein0202
Gag-Pol polyprotein0202
Gag-Pol polyprotein0202
CAAX prenyl protease 1 homolog0101
Plasmepsin V 0202
Protease 0437
Adenosine receptor A10101
Stromelysin-10202
Matrilysin0101
Multidrug transporter MdfA0202
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40505
Voltage-dependent L-type calcium channel subunit alpha-1C0303
DNA gyrase subunit B0101
Potassium voltage-gated channel subfamily E member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Potassium voltage-gated channel subfamily KQT member 10101
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
NPC intracellular cholesterol transporter 1 precursor2002
pyruvate kinase PKM isoform a1001
Endothelin receptor type B1001
Endothelin-1 receptor1001
Signal transducer and activator of transcription 30101
Pyruvate-flavodoxin oxidoreductase0101
Anoctamin-10101
STE240001
CAAX prenyl protease0001
Trypsin0001
Rap guanine nucleotide exchange factor 41001
Decaprenylphosphoryl-beta-D-ribose oxidase0102
interleukin 82002
lysosomal alpha-glucosidase preproprotein2002
rac GTPase-activating protein 1 isoform a0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cannabinoid receptor 10202
Prostaglandin G/H synthase 20202
Prostaglandin G/H synthase 2 0101
Prostaglandin G/H synthase 1 0101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nociceptin receptor0011
Estrogen receptor beta0202
dopamine D1 receptor1001
NAD-dependent protein deacetylase sirtuin-60202
Nicotinate phosphoribosyltransferase0101
Hydroxycarboxylic acid receptor 20011
Pyridoxal kinase0001
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1A40101
Nuclear receptor subfamily 1 group I member 20022
NH(3)-dependent NAD(+) synthetase0101
Arylacetamide deacetylase0102
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Chain A, HIV-1 PROTEASE0101
Chain B, HIV-1 PROTEASE0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, Endothiapepsin0101
Chain A, Endothiapepsin0101
Solute carrier family 22 member 20101
Solute carrier family 22 member 30101
Cytochrome P450 3A50101
Thromboxane-A synthase 0101
Vasopressin V1a receptor0202
Thromboxane-A synthase0001
Sodium/bile acid cotransporter0101
Multidrug and toxin extrusion protein 20101
4,4'-diapophytoene synthase0202
Geranylgeranyl pyrophosphate synthase0101
Translocator protein0101
Squalene synthase0202
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
Tetracycline resistance protein, class B0001
72 kDa type IV collagenase0101
Neutrophil collagenase0101
Collagenase 30101
Solute carrier family 22 member 80001
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Solute carrier family 22 member 70001
Parkin1001
Tryptophan 5-hydroxylase 10101
Histamine H1 receptor0101
Cathepsin D 0101
Sigma non-opioid intracellular receptor 10101
Mucosa-associated lymphoid tissue lymphoma translocation protein 10101
Thymidine phosphorylase0101
Transthyretin0112
Genome polyprotein0112
Krueppel-like factor 100101
Chain A, Purine nucleoside phosphorylase0101
Chain A, Purine nucleoside phosphorylase DeoD-type0101
NS5 0011
MSH0001
Hsf1 protein0012
glycogen synthase kinase-3 beta isoform 10011
Heat shock cognate 71 kDa protein0011
Adenosine kinase0101
Programmed cell death protein 40101
glucocerebrosidase1001
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
Potassium voltage-gated channel subfamily A member 30101
Delta-type opioid receptor0101
Multidrug resistance-associated protein 1 0214
Mu-type opioid receptor0101
Chloroquine resistance transporter0101
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]