Compounds > triazoles
Page last updated: 2024-08-24

triazoles and acridines

triazoles has been researched along with acridines in 49 studies

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19903 (6.12)18.7374
1990's4 (8.16)18.2507
2000's10 (20.41)29.6817
2010's24 (48.98)24.3611
2020's8 (16.33)2.80

Authors

AuthorsStudies
Cholody, WM; Konopa, J; Martelli, S1
Gibel, W; Schramm, T; Schwabe, K1
Hulanicka, MD; Kredich, NM; Treiman, DM1
Manis, JJ; Oliver, DR; Whitfield, HJ1
Arjunan, P; Arora, SK; Chalody, W1
Chołody, WM; Konopa, J; Kuśnierczyk, H; Paradziej-Lukowicz, J; Radzikowski, C1
Schepetkin, IA1
Heald, RA; Hutchinson, I; McCarroll, AJ; Stevens, MF1
Gueorguieva, M; Schloffer, D; Skladanowski, A; Uhl, M; Wesierska-Gadek, J1
Larsen, AK; Lemke, K; Poindessous, V; Skladanowski, A1
Baginski, M; Bailly, C; Colson, P; Laine, W; Larsen, AK; Lemke, K; Skladanowski, A; Wojciechowski, M1
Augustin, E; Konopa, J; Moś-Rompa, A; Skwarska, A; Witkowski, JM1
Koba, M; Konopa, J1
Assaraf, YG; Bram, EE; Grimberg, M; Ifergan, I; Lemke, K; Skladanowski, A1
Filichev, VV; Géci, I; Pedersen, EB1
Hirohama, T; Imoto, S; Nagatsugi, F1
Garner, TP; Gluszyk, KI; Moses, JE; Oldham, NJ; Roe, S; Searle, MS; Stevens, MF; Williams, HE1
Barnes, J; Bryce, RA; Caraher, MC; Doncaster, JR; Humphries, MP; Nolan, KA; Stratford, IJ; Tirelli, N; Whitehead, RC1
Sabisz, M; Skladanowski, A; Wesierska-Gadek, J1
Barodia, SK; Kumari, N; Luthra, PM; Mishra, CB; Prakash, A; Senthil Kumar, JB1
Doria, F; Gunaratnam, M; Haider, SM; Neidle, S; Sparapani, S1
De Pauw, E; Gabelica, V; Haider, S; Lombardo, CM; Martínez, IS; Moses, JE; Neidle, S1
Komina, O; Maurer, M; Składanowski, A; Wesierska-Gadek, J1
Fedejko-Kap, B; Mazerska, Z; Niemira, M; Radominska-Pandya, A1
Mazerska, Z; Nowicka, AM; Stojek, Z; Zabost, E1
Bratton, SM; Fedejko-Kap, B; Finel, M; Mazerska, Z; Radominska-Pandya, A1
Ferk, F; Komina, O; Maurer, M; Składanowski, A; Węsierska-Gądek, J; Zulehner, N1
Neidle, S; Oliveira-Brett, AM; Pontinha, AD; Sparapani, S1
Augustin, E; Borowa-Mazgaj, B; Kikulska, A; Kordalewska, M; Pawłowska, M1
Augustin, E; Chambers, TC; Chu, R; Fedejko-Kap, B; Mazerska, Z; Pawlowska, M; Radominska-Pandya, A1
Hao, GF; Yang, GF; Yang, WC; Yu, NX; Zhu, XL1
Dastych, J; Mazerska, Z; Niemira, M1
Augustin, E; Hołownia, A; Mazerska, Z; Niemira, M1
Lombardo, CM; Neidle, S; Oliveira-Brett, AM; Pontinha, AD1
Akbarzadeh, T; Alinezhad, H; Foroumadi, A; Khanavi, M; Mahdavi, M; Mohammadi-Khanaposhtani, M; Razkenari, EK; Sabourian, R; Saeedi, M; Shafiee, A; Zafarghandi, NS1
Augustin, E; Borowa-Mazgaj, B; Pelikant, I; Sankowska, E; Skwarska, A; Weryszko, A1
Chiorcea-Paquim, AM; Eritja, R; Lucarelli, G; Neidle, S; Oliveira-Brett, AM; Pontinha, AD; Sparapani, S1
Fedejko-Kap, B; Mazerska, Z; Potęga, A1
Bejrowska, A; Mazerska, Z; Mróz, A; Pawłowska, M1
Acelas, M; Kouznetsov, VV; Romero Bohórquez, AR1
Darkwa, J; Makhubela, BCE; Meyer, D; Rono, CK1
Augustin, E; Kwaśniewska, A; Mazerska, Z; Pawłowska, M1
Andrałojć, W; Gdaniec, Z; Grynda, J; Gwarda, P; Laskowski, T; Mazerski, J1
Bierbach, U; Brown-Harding, H; Watkins, NH; Yao, X1
Bagiński, M; Bartoszewska, S; Bartoszewski, R; Collawn, JF; Crossman, DK; Króliczewski, J; Pogorzelska, A1
Dokala, A; Gurrapu, N; Kolluri, PK; Praveenkumar, E; Subhashini, NJP1
Sachdeva, H; Saquib, M; Tanwar, K1
Bagiński, M; Bartoszewski, R; Dąbrowska, AM; Filip-Psurska, B; Gawrońska, M; Krzymiński, K; Milczarek, M; Moszyńska, A; Psurski, M; Świtalska, M; Wietrzyk, J1
Chen, R; Huo, L; Jaiswal, Y; Jia, Z; Liang, Y; Liu, X; Lu, R; Nong, Y; Williams, L; Xu, H1

Reviews

2 review(s) available for triazoles and acridines

ArticleYear
[Recommendations for testing and evaluation of drugs as to carcinogenicity].
    Archiv fur Geschwulstforschung, 1971, Volume: 37, Issue:1

    Topics: Acridines; Alcohols; Alkylating Agents; Animals; Antithyroid Agents; Azo Compounds; Carbazoles; Carcinogens; Coal Tar; Dextrans; Estrogens; Immunosuppressive Agents; Iron; Lactones; Methylthiouracil; Naphthoquinones; Paraffin; Phenylbutazone; Reserpine; Sulfhydryl Compounds; Sulfonamides; Sulfonic Acids; Tannins; Thiourea; Toxicology; Triazoles; Urethane; World Health Organization

1971
Design and Development of Triazole Derivatives as Prospective Anticancer Agents: A Review.
    Anti-cancer agents in medicinal chemistry, 2022, Volume: 22, Issue:19

    Topics: Acridines; Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Neoplasms; Prospective Studies; Pyrimidines; Structure-Activity Relationship; Triazoles

2022

Other Studies

47 other study(ies) available for triazoles and acridines

ArticleYear
8-Substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones as potential antineoplastic agents. Synthesis and biological activity.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:10

    Topics: Acridines; Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry, Physical; Dose-Response Relationship, Drug; Humans; Rats; Triazoles; Tumor Cells, Cultured

1990
The structural gene for O-acetylserine sulfhydrylase A in Salmonella typhimurium. Identity with the trzA locus.
    The Journal of biological chemistry, 1974, Feb-10, Volume: 249, Issue:3

    Topics: Acridines; Chromosome Mapping; Cross Reactions; Cysteine; Drug Resistance, Microbial; Genes; Genotype; Immunodiffusion; Lyases; Mutation; Nitrosoguanidines; Phosphotransferases; Salmonella typhimurium; Serine; Transduction, Genetic; Triazoles

1974
Evidence for a composite state of an F'his, gnd element and a cryptic plasmid in a derivative of Salmonella typhimurium LT2.
    Journal of bacteriology, 1974, Volume: 119, Issue:1

    Topics: Acridines; Alanine; Amino Alcohols; Carbon Radioisotopes; Centrifugation, Density Gradient; Conjugation, Genetic; DNA, Bacterial; DNA, Circular; Drug Resistance, Microbial; Extrachromosomal Inheritance; Histidine; Molecular Weight; Mutation; Operon; Phosphogluconate Dehydrogenase; Phosphoric Monoester Hydrolases; Salmonella typhimurium; Triazoles; Tritium

1974
Structural studies on DNA-binding drugs: crystal structure and molecular dynamics studies of triazoloacridinones.
    Acta crystallographica. Section B, Structural science, 1993, Feb-01, Volume: 49 ( Pt 1)

    Topics: Acridines; Antineoplastic Agents; DNA; Models, Molecular; Triazoles; X-Ray Diffraction

1993
Experimental antitumor activity and toxicity of the selected triazolo- and imidazoacridinones.
    Archivum immunologiae et therapiae experimentalis, 1994, Volume: 42, Issue:5-6

    Topics: Acridines; Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Imidazoles; Lethal Dose 50; Leukemia P388; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasm Transplantation; Triazoles

1994
Lucigenin luminescence elicited by microsomes and its modulation by nitroazole compounds.
    IUBMB life, 1999, Volume: 48, Issue:5

    Topics: Acridines; Animals; Cattle; Horses; Luminescent Measurements; Male; Metronidazole; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Superoxide Dismutase; Triazoles; Xanthine Oxidase

1999
Synthesis and properties of bioactive 2- and 3-amino-8-methyl-8H-quino[4,3,2-kl]acridine and 8,13-dimethyl-8H-quino[4,3,2-kl]acridinium salts.
    Organic & biomolecular chemistry, 2004, Jan-21, Volume: 2, Issue:2

    Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Cyclization; Hot Temperature; Humans; Inhibitory Concentration 50; Solvents; Structure-Activity Relationship; Triazoles

2004
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest.
    Cancer research, 2004, Jul-01, Volume: 64, Issue:13

    Topics: Acridines; Amsacrine; Animals; Apoptosis; CDC2 Protein Kinase; Cell Division; Cyclin B; DNA Damage; Fibroblasts; G2 Phase; Mice; Mice, Knockout; Poly(ADP-ribose) Polymerases; Topoisomerase II Inhibitors; Triazoles; Tumor Suppressor Protein p53

2004
The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties.
    Molecular pharmacology, 2004, Volume: 66, Issue:4

    Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Catalytic Domain; DNA; DNA Topoisomerases, Type II; Drug Interactions; Drug Screening Assays, Antitumor; Gene Expression; HL-60 Cells; Humans; Mice; Multidrug Resistance-Associated Proteins; NIH 3T3 Cells; Plasmids; Razoxane; Spheroids, Cellular; Time Factors; Topoisomerase II Inhibitors; Triazoles; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2004
Induction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with antitumor activities.
    Nucleic acids research, 2005, Volume: 33, Issue:18

    Topics: Acridines; Antineoplastic Agents; Circular Dichroism; Deoxyribonuclease I; DNA; DNA Footprinting; Enzyme Inhibitors; Guanine; Intercalating Agents; Models, Molecular; Phosphorylcholine; Spectrophotometry; Structure-Activity Relationship; Topoisomerase II Inhibitors; Triazoles

2005
Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305.
    Biochemical pharmacology, 2006, Dec-15, Volume: 72, Issue:12

    Topics: Acridines; Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Cell Division; Cell Line, Tumor; Cell Proliferation; Electrophoresis, Agar Gel; Flow Cytometry; G2 Phase; HL-60 Cells; Humans; In Situ Nick-End Labeling; Intracellular Membranes; Leukemia; Membrane Potentials; Mitochondria; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Triazoles

2006
Interactions of antitumor triazoloacridinones with DNA.
    Acta biochimica Polonica, 2007, Volume: 54, Issue:2

    Topics: Acridines; Acridones; Animals; Antineoplastic Agents; Biotransformation; Cross-Linking Reagents; DNA; DNA, Neoplasm; HeLa Cells; HL-60 Cells; Humans; Intercalating Agents; Mice; NIH 3T3 Cells; Nucleic Acid Conformation; Triazoles

2007
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
    Biochemical pharmacology, 2007, Jun-30, Volume: 74, Issue:1

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Amplification; Gene Expression Regulation, Neoplastic; Heterozygote; Humans; Indoles; Irinotecan; Mitoxantrone; Neoplasm Proteins; RNA, Messenger; Triazoles

2007
Stabilization of parallel triplexes by twisted intercalating nucleic acids (TINAs) incorporating 1,2,3-triazole units and prepared by microwave-accelerated click chemistry.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Volume: 13, Issue:22

    Topics: Acridines; DNA; Intercalating Agents; Microwaves; Models, Molecular; Nucleic Acid Conformation; Oligonucleotides; Spectrometry, Fluorescence; Triazoles

2007
DNA-templated click chemistry for creation of novel DNA binding molecules.
    Bioorganic & medicinal chemistry letters, 2008, Oct-15, Volume: 18, Issue:20

    Topics: Acridines; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; DNA; Drug Design; Intercalating Agents; Kinetics; Models, Chemical; Nucleic Acid Conformation; Peptides; Protein Binding; Temperature; Triazoles

2008
Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.
    Organic & biomolecular chemistry, 2009, Oct-21, Volume: 7, Issue:20

    Topics: Acridines; Circular Dichroism; DNA; Enzyme Inhibitors; G-Quadruplexes; Humans; Ligands; Mass Spectrometry; Molecular Dynamics Simulation; Proto-Oncogene Proteins c-kit; Substrate Specificity; Telomerase; Telomere; Triazoles

2009
Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2.
    Bioorganic & medicinal chemistry, 2010, Jan-15, Volume: 18, Issue:2

    Topics: Acridines; Animals; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; DNA; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Male; Models, Molecular; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Quinone Reductases; Salmon; Spermatozoa; Structure-Activity Relationship; Transition Temperature; Triazoles

2010
Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints.
    Biochemical pharmacology, 2010, May-15, Volume: 79, Issue:10

    Topics: Acridines; Apoptosis; Blotting, Western; Cell Cycle; Cell Death; Cyclin B1; DNA Damage; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Gene Expression Regulation; HeLa Cells; Humans; Mitosis; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Polyploidy; Proteasome Endopeptidase Complex; Quinazolines; Topoisomerase II Inhibitors; Triazoles; Tumor Suppressor Protein p53

2010
Novel 8-(furan-2-yl)-3-benzyl thiazolo [5,4-e][1,2,4] triazolo [1,5-c] pyrimidine-2(3H)-thione as selective adenosine A(2A) receptor antagonist.
    Neuroscience letters, 2011, Jan-13, Volume: 488, Issue:1

    Topics: Acridines; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cell Line, Transformed; Chloroquinolinols; Corpus Striatum; Cyclic AMP; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Mice; Models, Molecular; Phenethylamines; Protein Binding; Pyrimidines; Receptors, Adenosine A2; Time Factors; Triazoles; Tritium

2011
Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.
    Journal of the American Chemical Society, 2010, Sep-08, Volume: 132, Issue:35

    Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fibroblasts; G-Quadruplexes; Humans; Ligands; Models, Molecular; Molecular Structure; Proto-Oncogene Proteins c-kit; Stereoisomerism; Structure-Activity Relationship; Telomerase; Telomere; Triazoles

2010
Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.
    Chemical communications (Cambridge, England), 2010, Dec-28, Volume: 46, Issue:48

    Topics: Acridines; Computer Simulation; Drug Design; G-Quadruplexes; Ligands; Small Molecule Libraries; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Telomere; Triazoles

2010
Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle.
    Journal of experimental therapeutics & oncology, 2011, Volume: 9, Issue:1

    Topics: Acridines; Breast Neoplasms; Cyclin-Dependent Kinase 2; Female; G2 Phase; HL-60 Cells; Humans; Immunoblotting; Phosphorylation; Topoisomerase II Inhibitors; Triazoles; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2011
Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells.
    Xenobiotica; the fate of foreign compounds in biological systems, 2011, Volume: 41, Issue:12

    Topics: Acridines; Aminoacridines; Animals; Antineoplastic Agents; Biocatalysis; Biotransformation; Cell Hypoxia; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hep G2 Cells; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Microsomes, Liver; Oxygenases; Rats; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Tissue Donors; Triazoles

2011
Influence of temperature and interactions with ligands on dissociation of dsDNA and ligand-dsDNA complexes of various types of binding. An electrochemical study.
    Physical chemistry chemical physics : PCCP, 2012, Mar-14, Volume: 14, Issue:10

    Topics: Acridines; Aminoacridines; Animals; Binding Sites; Bisbenzimidazole; Cattle; DNA; Electrochemistry; Ligands; Molecular Structure; Nucleic Acid Denaturation; Organometallic Compounds; Temperature; Triazoles

2012
Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:9

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; Biotransformation; Catalysis; Chromatography, High Pressure Liquid; Glucuronides; Glucuronosyltransferase; Humans; Intestines; Kinetics; Liver; Microsomes, Liver; Models, Biological; Mutation; Recombinant Proteins; Substrate Specificity; Triazoles

2012
PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells.
    Biochemical pharmacology, 2012, Nov-15, Volume: 84, Issue:10

    Topics: Acridines; Antineoplastic Agents; Apoptosis; BRCA1 Protein; Breast Neoplasms; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Breaks; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Topoisomerase II Inhibitors; Triazoles; Tumor Suppressor Protein p53

2012
Triazole-acridine conjugates: redox mechanisms and in situ electrochemical evaluation of interaction with double-stranded DNA.
    Bioelectrochemistry (Amsterdam, Netherlands), 2013, Volume: 89

    Topics: Acridines; Biosensing Techniques; DNA; Electrochemistry; Hydrogen-Ion Concentration; Oxidation-Reduction; Triazoles

2013
CYP3A4 overexpression enhances the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in CHO cells.
    Acta pharmacologica Sinica, 2013, Volume: 34, Issue:1

    Topics: Acridines; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 CYP3A; Cytotoxins; Humans; Triazoles; Up-Regulation

2013
Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:2

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; Biotransformation; Cell Survival; Dose-Response Relationship, Drug; Female; Glucuronides; Glucuronosyltransferase; HeLa Cells; Humans; Inhibitory Concentration 50; Transfection; Triazoles; Uterine Cervical Neoplasms

2013
Structural basis of femtomolar inhibitors for acetylcholinesterase subtype selectivity: insights from computational simulations.
    Journal of molecular graphics & modelling, 2013, Volume: 41

    Topics: Acetylcholinesterase; Acridines; Animals; Binding Sites; Cholinesterase Inhibitors; Drosophila melanogaster; Isoenzymes; Mice; Molecular Dynamics Simulation; Phenanthridines; Protein Binding; Structure-Activity Relationship; Tacrine; Thermodynamics; Torpedo; Triazoles

2013
Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia.
    Biochemical pharmacology, 2013, Jul-15, Volume: 86, Issue:2

    Topics: Acridines; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; DNA Primers; Hep G2 Cells; Humans; Hypoxia; Nitracrine; Pregnane X Receptor; Real-Time Polymerase Chain Reaction; Receptors, Steroid; Triazoles; Up-Regulation

2013
CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells.
    Cell biology international, 2014, Volume: 38, Issue:11

    Topics: Acridines; Antineoplastic Agents; Biocatalysis; Cell Cycle Checkpoints; Cell Survival; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Hep G2 Cells; Humans; Mass Spectrometry; Nitracrine; Triazoles

2014
Triazole-linked phenyl derivatives: redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA.
    Bioelectrochemistry (Amsterdam, Netherlands), 2015, Volume: 101

    Topics: Acridines; Biosensing Techniques; Carbon; DNA; Electrochemical Techniques; Hydrogen-Ion Concentration; Oxidation-Reduction; Solutions; Triazoles

2015
Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives.
    European journal of medicinal chemistry, 2015, Mar-06, Volume: 92

    Topics: Acetylcholinesterase; Acridines; Acridones; Animals; Antioxidants; Cholinesterase Inhibitors; Culicidae; Dose-Response Relationship, Drug; Drug Design; Electrophorus; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles

2015
The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
    Acta pharmacologica Sinica, 2015, Volume: 36, Issue:3

    Topics: Acridines; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Proliferation; Dose-Response Relationship, Drug; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mitogen-Activated Protein Kinases; Molecular Targeted Therapy; Mutation; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; STAT5 Transcription Factor; Time Factors; Transfection; Triazoles; U937 Cells

2015
Atomic Force Microscopy and Voltammetric Investigation of Quadruplex Formation between a Triazole-Acridine Conjugate and Guanine-Containing Repeat DNA Sequences.
    Analytical chemistry, 2015, Jun-16, Volume: 87, Issue:12

    Topics: Acridines; DNA; Electrochemical Techniques; G-Quadruplexes; Guanine; Microscopy, Atomic Force; Molecular Structure; Repetitive Sequences, Nucleic Acid; Triazoles

2015
Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by anti-tumor triazoloacridinone C-1305.
    Xenobiotica; the fate of foreign compounds in biological systems, 2016, Volume: 46, Issue:12

    Topics: Acridines; Antineoplastic Agents; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Humans; Triazoles

2016
Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:3

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Glucuronides; Glucuronosyltransferase; Hep G2 Cells; HT29 Cells; Humans; Irinotecan; Isoenzymes; Microsomes, Liver; Triazoles

2018
Facile and highly diastereo and regioselective synthesis of novel octahydroacridine-isoxazole and octahydroacridine-1,2,3-triazole molecular hybrids from citronella essential oil.
    Molecular diversity, 2019, Volume: 23, Issue:1

    Topics: Acridines; Alkynes; Catalysis; Copper; Cycloaddition Reaction; Cymbopogon; Isoxazoles; Oils, Volatile; Triazoles

2019
A Novel Series of N-aryltriazole and N-acridinyltriazole Hybrids as Potential Anticancer Agents.
    Current organic synthesis, 2019, Volume: 16, Issue:6

    Topics: Acridines; Alkynes; Antineoplastic Agents; Azides; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Cycloaddition Reaction; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Molecular Structure; Structure-Activity Relationship; Triazoles

2019
Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs' Cytotoxicity, Metabolism and Cellular Response.
    International journal of molecular sciences, 2020, May-31, Volume: 21, Issue:11

    Topics: Acridines; Aminoacridines; Antineoplastic Agents; Apoptosis; Biotransformation; Cell Line, Tumor; Cytochrome P-450 CYP3A; Drug Design; Drug Screening Assays, Antitumor; Glucuronides; Glucuronosyltransferase; HCT116 Cells; Humans; Isoenzymes; MCF-7 Cells; Membrane Potential, Mitochondrial; Necrosis; Substrate Specificity; Triazoles

2020
A strong preference for the TA/TA dinucleotide step discovered for an acridine-based, potent antitumor dsDNA intercalator, C-1305: NMR-driven structural and sequence-specificity studies.
    Scientific reports, 2020, 07-16, Volume: 10, Issue:1

    Topics: Acridines; Adenine Nucleotides; Antineoplastic Agents; Base Sequence; Binding Sites; DNA; Drug Discovery; Intercalating Agents; Ligands; Models, Molecular; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Thymine Nucleotides; Triazoles

2020
A membrane transporter determines the spectrum of activity of a potent platinum-acridine hybrid anticancer agent.
    Scientific reports, 2020, 09-16, Volume: 10, Issue:1

    Topics: A549 Cells; Acridines; Antineoplastic Agents; Benzamides; Biphenyl Compounds; Cell Proliferation; Cell Survival; Drug Synergism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Molecular Structure; Morpholines; Organic Cation Transport Proteins; Organoplatinum Compounds; Platinum; Pyridones; Pyrimethamine; Sulfones; Triazoles

2020
Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor.
    Cellular & molecular biology letters, 2021, Mar-17, Volume: 26, Issue:1

    Topics: Acridines; Cell Line; Endoplasmic Reticulum Stress; Endoribonucleases; Humans; Hymecromone; Protein Serine-Threonine Kinases; RNA Splicing; RNA, Messenger; Triazoles; X-Box Binding Protein 1

2021
Selective CDK4/6 inhibition of novel 1,2,3-triazole tethered acridinedione derivatives induces G1/S cell cycle transition arrest via Rb phosphorylation blockade in breast cancer models.
    Bioorganic chemistry, 2021, Volume: 116

    Topics: Acridines; Antineoplastic Agents; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Dose-Response Relationship, Drug; Female; Humans; Models, Molecular; Molecular Structure; Phosphorylation; Protein Kinase Inhibitors; Retinoblastoma; Structure-Activity Relationship; Triazoles

2021
Combined anticancer therapy with imidazoacridinone analogue C-1305 and paclitaxel in human lung and colon cancer xenografts-Modulation of tumour angiogenesis.
    Journal of cellular and molecular medicine, 2022, Volume: 26, Issue:14

    Topics: Acridines; Apoptosis; Colonic Neoplasms; Heterografts; Humans; Lung; Lung Neoplasms; Paclitaxel; Triazoles

2022
Design and Synthesis of Acridine-Triazole and Acridine-Thiadiazole Derivatives and Their Inhibitory Effect against Cancer Cells.
    International journal of molecular sciences, 2022, Dec-21, Volume: 24, Issue:1

    Topics: Acridines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dermatologic Agents; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Thiadiazoles; Triazoles; Zebrafish

2022