An antogonist that blocks chemokine receptor 2 (CCR2).
ChEBI ID: 149711
| Member | Definition | Class |
|---|---|---|
| cenicriviroc | A member of the class of benzazocines that is (5Z)-1,2,3,4-tetrahydro-1-benzazocine which is substituted by a 2-methylpropyl, N-{4-[(S)-(1-propyl-1H-imidazol-5-yl)methanesulfinyl]phenyl}carboxamide and 4-(2-butoxyethoxy)phenyl groups at positions 1, 5 and 8, respectively. It is a potent chemokine 2 and 5 receptor antagonist currently in development for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis (NASH). | cenicriviroc |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (9.62) | 29.6817 |
| 2010's | 29 (55.77) | 24.3611 |
| 2020's | 18 (34.62) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 12 (23.08%) | 5.53% |
| Reviews | 13 (25.00%) | 6.00% |
| Case Studies | 1 (1.92%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 26 (50.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| C-C chemokine receptor type 2 | Homo sapiens (human) | IC50 | 0.0059 | 2 | 2 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
| C-C chemokine receptor type 5 | Mus musculus (house mouse) | IC50 | 0.0002 | 1 | 1 |
| C-C chemokine receptor type 7 | Homo sapiens (human) | IC50 | 0.0031 | 1 | 1 |