Page last updated: 2024-09-27

Central Nervous System Phaeohyphomycosis

CNS infections caused by neurotropic dematiaceous fungi that contain melanin in their cell walls. The infections often result in BRAIN ABSCESS; ENCEPHALITIS; and MENINGITIS in patients who are often immunocompetent. The common causative fungi include members Cladophialophora bantiana, Exophiala dermatitidis, Rhinocladiella mackenziei, and Ochroconis gallopavum. R. mackenziei infection is seen almost exclusively in patients from the MIDDLE EAST.

Synonyms(6)

Synonym
Primary Central Nervous System Phaeohyphomycosis
Cerebral Phaeohyphomycosis
Phaeohyphomycosis, Central Nervous System, Primary
Central Nervous System Phaeohyphomycosis, Primary
Phaeohyphomycosis, Central Nervous System
Central Nervous System Phaeohyphomycosis

Research Excerpts

Overview

ExcerptReference
"Primary central nervous system phaeohyphomycosis is a fatal fungal infection due mainly to the neurotropic melanized fungiCladophialophora bantiana,Rhinocladiella mackenziei, andExophiala dermatitidis."( de Hoog, GS; Deng, S; Gerrits van den Ende, AH; Ilkit, M; Liao, W; Pan, W; Rafati, H; Rijs, AJ; Seyedmousavi, S; Van der Lee, AH; Verweij, PE; Vitale, RG, 2016)

Research

Studies (10)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's8 (80.00)28.8240
2020's2 (20.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
fluconazole0low10
flucytosine0low10
triazoles0low50
voriconazole0low60
posaconazole0low10
amphotericin b0low30
isavuconazole0low10

Protein Targets (151)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, Cruzipain1001
interleukin 81001
phosphopantetheinyl transferase2002
GLS protein1001
glucocorticoid receptor [Homo sapiens]3003
farnesoid X nuclear receptor3003
peroxisome proliferator-activated receptor delta2002
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA1001
nuclear factor erythroid 2-related factor 2 isoform 13003
peripheral myelin protein 221001
lamin isoform A-delta103003
Cytochrome P450 1A20101
Cytochrome P450 3A40404
Cytochrome P450 2D60101
Cytochrome P450 2C9 0404
Cytochrome P450 2C190202
Nuclear receptor ROR-gamma1001
Potassium voltage-gated channel subfamily H member 20202
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20303
Chain A, BCL-2-RELATED PROTEIN A10011
acetylcholinesterase1001
GLI family zinc finger 33003
apical membrane antigen 1, AMA11001
cytochrome P450 family 3 subfamily A polypeptide 45005
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha3003
pregnane X nuclear receptor3003
estrogen nuclear receptor alpha3003
G5005
cytochrome P450 2D62002
unnamed protein product0101
chromobox protein homolog 11001
transcriptional regulator ERG isoform 31001
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase iota isoform a (long)2002
geminin2002
cytochrome P450 3A4 isoform 11001
bcl-2-like protein 11 isoform 10011
Gamma-aminobutyric acid receptor subunit pi1001
Histone deacetylase 30101
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0404
Rap guanine nucleotide exchange factor 32002
Chymotrypsinogen A0101
Beta-lactamase0101
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p533003
Steroid 17-alpha-hydroxylase/17,20 lyase0202
Heme oxygenase 1 0101
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10101
Lanosterol 14-alpha demethylase0134
Aromatase0202
Gamma-aminobutyric acid receptor subunit beta-11001
Cytochrome P450 11B1, mitochondrial0202
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Cytochrome P450 11B2, mitochondrial0202
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
ATP-dependent translocase ABCB10101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Heme oxygenase 20101
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Malate dehydrogenase, cytoplasmic0101
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Cytochrome P450 1440033
Steroid C26-monooxygenase0033
Steroid C26-monooxygenase0033
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
TAR DNA-binding protein 431001
Histone deacetylase 10101
Lanosterol 14-alpha demethylase0112
Sterol 14-alpha demethylase0033
Sterol 14-alpha demethylase0224
Histone deacetylase 70101
GABA theta subunit1001
Inositol hexakisphosphate kinase 15005
Histone deacetylase 20101
Canalicular multispecific organic anion transporter 10404
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
14-alpha sterol demethylase 0033
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit epsilon1001
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
cytochrome P450 2C9, partial5005
heat shock protein 90, putative0001
likely tRNA 2'-phosphotransferase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Skn7p0001
AR protein3003
EWS/FLI fusion protein3003
nonstructural protein 11001
heat shock protein 900011
calcineurin A1, putative0011
serine/threonine-protein kinase PLK11001
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Spike glycoprotein3003
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma2002
Fumarate hydratase2002
GALC protein1001
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 32002
estrogen-related nuclear receptor alpha2002
polyprotein2002
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
thyroid hormone receptor beta isoform 22002
heat shock protein beta-11001
Voltage-dependent calcium channel gamma-2 subunit2002
Glutamate receptor 22002
Sterol 14-alpha-demethylase0022
SMAD family member 21001
SMAD family member 31001
TDP1 protein1001
caspase 7, apoptosis-related cysteine protease1001
progesterone receptor1001
peroxisome proliferator activated receptor gamma1001
caspase-31001
thyroid stimulating hormone receptor1001
14-alpha sterol demethylase 0022
ATPase family AAA domain-containing protein 51001
Ataxin-21001
14-alpha sterol demethylase 0022
mitogen-activated protein kinase 11001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
Cytochrome P450 2B60101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Cholesterol 24-hydroxylase0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]