Compounds > kpt-251
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kpt-251

Description

KPT-251: a selective inhibitor of nuclear export; structure in first source [MeSH]

Cross-References

ID SourceID
PubMed CID57519758
SCHEMBL ID11318201
MeSH IDM000612883

Synonyms (16)

Synonym
SCHEMBL11318201
kpt251
1388841-50-6
kpt-251
AKOS027324202
HY-117996
NCGC00351777-01
(z)-2-(2-(3-(3,5-bis(trifluoromethyl)phenyl)-1h-1,2,4-triazol-1-yl)vinyl)-1,3,4-oxadiazole ,
(z)-2-{2-[3-(3,5-bis-trifluoromethyl-phenyl)-[1,2,4]triazol-1-yl]-vinyl}-[1,3,4]oxadiazole
ldfxtrymmzgkic-uphrsurjsa-n
2-[(z)-2-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]ethenyl]-1,3,4-oxadiazole
nsc-773260
nsc773260
CS-0068815
PD194909
F90220

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
ISSN: 2472-5560		Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111		A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111		A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490		Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490		Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's2 (28.57)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
prednisone
1
11-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
immunosuppressive agent;
prodrug		201620168.0low000010
thiazoles
3
1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		201520168.7medium000030
hydrazine
4
azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor201520168.8medium000040
triazoles
4
1,2,3-triazole201520168.8medium000040
everolimus
1
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
primary alcohol;
secondary alcohol		anticoronaviral agent;
antineoplastic agent;
geroprotector;
immunosuppressive agent;
mTOR inhibitor		201620168.0low000010
oxadiazoles
4
201520168.8medium000040
selinexor
4
201520168.8medium000040
kpt-276
3
201520168.7high000030
cyclin d1
1
201520159.0low000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Astrocytoma, Grade IV0
1
201520159.0low000010
Benign Neoplasms, Brain0
1
201520159.0low000010
Brain Neoplasms0
1
201520159.0low000010
Cancer of Lung0
1
201520159.0low000010
Cancer of Prostate0
1
201520159.0low000010
Congenital Zika Syndrome0
1
202020204.0low000010
Diffuse Mixed Small and Large Cell Lymphoma0
1
201620168.0low000010
Disease Models, Animal0
1
202020204.0low000010
Glioblastoma0
1
201520159.0low000010
Lung Neoplasms0
1
201520159.0low000010
Lymphoma, Non-Hodgkin0
1
201620168.0low000010
Malignant Mesothelioma0
1
201520159.0low000010
Mesothelioma0
1
201520159.0low000010
Peritoneal Carcinomatosis0
1
201520159.0low000010
Peritoneal Neoplasms0
1
201520159.0low000010
Prostatic Neoplasms0
1
201520159.0low000010
Zika Virus Infection0
1
202020204.0low000010

Bioavailability (1)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, , Volume: 96, Issue:5		2019

Interactions (1)

ArticleYear
Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.
Cancer letters, , 12-28, Volume: 383, Issue:2		2016