Compounds > tris-(2,4-di-tert-butylphenyl) phosphite
Page last updated: 2024-11-06

tris-(2,4-di-tert-butylphenyl) phosphite

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tris-(2,4-di-tert-butylphenyl) phosphite, also known as tris(2,4-di-tert-butylphenyl) phosphite, is a hindered phosphite ester. It is a versatile compound with applications in various fields, including polymer chemistry, catalysis, and as a stabilizer in organic materials. It is commonly used as a stabilizer in polymers to prevent oxidation and degradation, particularly in polyolefins. Its bulky tert-butyl groups provide steric hindrance, preventing the phosphite from reacting with free radicals that can lead to polymer degradation. The synthesis of tris-(2,4-di-tert-butylphenyl) phosphite typically involves the reaction of 2,4-di-tert-butylphenol with phosphorus trichloride. The hindered nature of the phosphite ester makes it a suitable ligand for transition metal catalysts, playing a role in various catalytic reactions. The compound has also been studied for its potential applications in the development of new flame retardants and antioxidants. Its unique properties, including its steric hindrance and its ability to scavenge free radicals, make it a promising candidate for these applications.'

tris-(2,4-di-tert-butylphenyl) phosphite: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID91601
CHEBI ID144343
SCHEMBL ID26607
MeSH IDM0222707

Synonyms (60)

Synonym
AC-15273
tris(2,4-di-tert-butylphenyl) phosphite, 98%
tris(2,4-ditert-butylphenyl) phosphite
phenol, 2,4-di-tert-butyl-, phosphite (3:1)
irgafos 168
einecs 250-709-6
phenol, 2,4-bis(1,1-dimethylethyl)-, phosphite (3:1)
31570-04-4
tris(2,4-di-tert-butylphenyl) phosphite
tris(2,4-di-tert-butylphenyl)phosphite
AKOS001482440
FT-0655843
phosphorous acid tris(2,4-di-tert-butylphenyl) ester
P1421
CHEBI:144343
tris(2,4-di-t-butylphenyl)phosphite
tris(2,4-ditert-butylphenyl)phosphite
A820911
phenol, 2,4-bis(1,1-dimethylethyl)-, 1,1',1''-phosphite
unii-834e5h0lff
834e5h0lff ,
tris-(2,4-di-tert-butylphenyl) phosphite
ec 250-709-6
c42h63o3p
tris-(2,4-di-tert-butylphenyl)phosphite
BP-12274
irgafos-168
plastic additive 5
phosphite 168
jp-650
tris (2,4-di-tert-butyl-phenyl)phosphite
everfos 168
2,4-bis(1,1-dimethylethyl)phenol phosphite (3:1)
doverphos s 480
tris(2,4-tert-butylphenyl) phosphite
plastic additive 5 [usp-rs]
SCHEMBL26607
hostanox par 24
tris-(2,4-di-t-butylphenyl) phosphite
lowinox 242
naugard 524
alkanox 240
tris (2,4-di-tert-butylphenyl) phosphite
tris(2,4-di-tert butylphenyl)phosphite
tris(2,4-di-tert.butylphenyl)phosphite
antioxidant 168 ,
DTXSID2027969
sr-01000391442
SR-01000391442-1
mfcd00072706
plastic additive 5, united states pharmacopeia (usp) reference standard
D70443
plastic additive 12, european pharmacopoeia (ep) reference standard
tris(2,4-di-t-butylphenyl) phosphite
tris(2,4-ditertbutylphenyl)phosphite
tris(2,4-di-tert-butylphenyl)phosphite 100 microg/ml in acetonitrile
AS-12273
as 2112; at 168; alkanox 240; alkanox p 240; antioxidant 168
Q27269395
CS-0035260
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
alkylbenzeneA monocyclic arene that is benzene substituted with one or more alkyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (13.33)18.2507
2000's5 (33.33)29.6817
2010's4 (26.67)24.3611
2020's4 (26.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 40.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index40.89 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.90 (4.65)
Search Engine Demand Index55.05 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (40.89)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		2.0210aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
2-propanol
2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.. propan-2-ol : A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.		2.1510secondary alcohol;
secondary fatty alcohol		protic solvent
bisphenol a
4,4'-isopropylidene diphenol: stimulates proliferative responses and cytokine productions of murine spleen cells and thymus cells in vitro. bisphenol : By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom.. bisphenol A : A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.		2.2510bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
n-vinyl-2-pyrrolidinone
N-vinyl-2-pyrrolidinone: monomer of POVIDONE; structure given in first source		2.0510pyrrolidin-2-ones
styrene
Styrene: A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.. styrene : A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.		2.0210styrenes;
vinylarene;
volatile organic compound		mouse metabolite;
mutagen;
plant metabolite
caprolactam
Caprolactam: Cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. Can cause local irritation.. epsilon-caprolactam : A member of the class of caprolactams that is azepane substituted by an oxo group at position 2.		2.0210caprolactamshuman blood serum metabolite
diethylhexyl phthalate
Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.		2.0210diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		2.110alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
(2-hydroxy-4-(octyloxy)phenyl)phenylmethanone
2-hydroxy-4-octyloxybenzophenone: exhibits pseudo-positive initiation activity in carcinogenesis; structure in first source		2.0210benzophenones
irganox 1076
[no description available]		2.4320
drometrizole
drometrizole: structure in first source		1.9910triazoles
sodium persulfate
sodium persulfate: RN given refers to peroxydisulfuric acid, di-Na salt		2.0310
irganox 1010
pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate): has antioxidant activity		2.7930
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		1.99101,2,3-triazole
phosphites
Phosphites: Inorganic salts or organic esters of phosphorous acid that contain the (3-)PO3 radical. (From Grant & Hackh's Chemical Dictionary, 5th ed). phosphite(3-) : A trivalent inorganic anion obtained by removal of all three protons from phosphorous acid.		5.16140phosphite ion;
trivalent inorganic anion
1,4-diphenylbutadiene
[no description available]		2.0210styrenes
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0510