| Assay ID | Title | Year | Journal | Article |
|---|
| AID33337 | Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat adenosine A3 receptor | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
| AID30817 | Negative chronotropic activity via A2 Adenosine receptor was tested monitoring vasodilation in rat aorta | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. |
| AID228181 | Dose producing 10% decrease in heart rate of anesthetized spontaneously hypertensive rats (SHR's) | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity. |
| AID233405 | Ratio between Ki values of A1 and A2 receptors was determined | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. |
| AID31721 | Affinity for adenosine A1 receptor assayed in a competition assay in rat brain using [3H]-CHA as radioligand | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. |
| AID227038 | Selectivity as ratio of IC50 for A1 adenosine receptor compared to EC50 for A2 adenosine receptor | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID33427 | Affinity for the adenosine A2 receptor was evaluated in a competition assay in rat striatum using [3H]-CGS- 21680 as radioligand | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. |
| AID31417 | Inhibition of adenylate cyclase via adenosine A1 receptors in rat fat cell membranes | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID227155 | Selectivity as A1 adenosine receptors(high affinity) using [3H]CCPA compared to A2 adenosine receptors using [3H]-NECA in rat striatal membranes | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID31266 | Negative chronotropic activity via A1 Adenosine receptor was tested in spontaneously beating rat atria | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. |
| AID31859 | Binding affinity against adenosine A1 receptor from rat brain using [3H]CHA as a radioligand. | 1995 | Journal of medicinal chemistry, Apr-28, Volume: 38, Issue:9
| 2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists. |
| AID30794 | Agonistic activity at adenosine A2 receptor | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID32031 | Binding affinity against low affinity component of adenosine A1 receptors from rat brain membranes using [3H]-DPCPX | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID25037 | Hydrophobicity index (k') (RP-HPLC) | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. |
| AID32029 | Binding affinity against high affinity component of adenosine A1 receptors from rat brain membranes using [3H]DPCPX | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID33769 | Functional activity against adenosine A2a receptor from rat aorta. | 1995 | Journal of medicinal chemistry, Apr-28, Volume: 38, Issue:9
| 2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists. |
| AID32025 | Binding affinity against adenosine A1 receptor from rat brain membranes using [3H]cyclohexyladenosine as radioligand. | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity. |
| AID30633 | Maximal NECA stimulation of adenylate cyclase via adenosine A2 receptor in human platelet membranes | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID234752 | Selectivity as the ratio of Ki value towards A1 receptor to that of A2a receptor. | 1995 | Journal of medicinal chemistry, Apr-28, Volume: 38, Issue:9
| 2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists. |
| AID33574 | Binding affinity against adenosine A2 receptor from rat striatum using [3H]NECA as radioligand. | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity. |
| AID231406 | Inhibition compared to inhibition by NECA (IC50 ratio) of rabbit platelet aggregation induced by ADP | 1994 | Journal of medicinal chemistry, May-27, Volume: 37, Issue:11
| 2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. |
| AID227156 | Selectivity as A1 adenosine receptors(high affinity) using [3H]-DPCPX compared to A2 adenosine receptors using [3H]NECA in rat striatal membranes | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID31260 | Adenosine A1 receptor mediated negative chronotropic activity in spontaneously beating rat atria | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| 2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors. |
| AID232497 | Relative affinities for Adenosine A1 and A2A receptors | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| 2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors. |
| AID33634 | Anti-aggregatory activity against adenosine A2A receptor from rabbit platelets. Potency ratio was reported with reference to the NECA IC50 of 0.2 uM. | 1995 | Journal of medicinal chemistry, Apr-28, Volume: 38, Issue:9
| 2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists. |
| AID33790 | Binding affinity against adenosine A2a receptor from rat striatum using [3H]-CGS- 21680 as a radioligand. | 1995 | Journal of medicinal chemistry, Apr-28, Volume: 38, Issue:9
| 2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists. |
| AID32027 | Binding affinity against adenosine A1 receptors from rat brain membranes using [3H]CCPA | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID33792 | Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
| AID32351 | Displacement of [3H]CHA from Adenosine A1 receptor of rat brain | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| 2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors. |
| AID25036 | Hydrophobicity index (k'') (RP-HPLC pH 7.5) | 1995 | Journal of medicinal chemistry, Apr-28, Volume: 38, Issue:9
| 2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists. |
| AID234758 | Selectivity determined as Ratio of Ki(nM) of A1 adenosine receptor to the Ki(nM) of A2 adenosine receptor | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity. |
| AID33770 | Vasorelaxation as Adenosine A2A receptor activity in rat aorta | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| 2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors. |
| AID30654 | Binding affinity against adenosine A2 receptor from human platelet membranes using [3H]NECA | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID232334 | Ratio of inhibition of ADP-induced rabbit platelet aggregation and Adenosine A2a receptor binding | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| 2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors. |
| AID33935 | Displacement of [3H]-CGS- 51680 from Adenosine A2A receptor of rat striatum. | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| 2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors. |
| AID33573 | Binding affinity against adenosine A2 receptor from rat striatal membranes with 50 nM CPA using [3H]-NECA | 1992 | Journal of medicinal chemistry, Jun-26, Volume: 35, Issue:13
| 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
| AID228183 | Dose producing 30% decrease in blood pressure of anesthetized spontaneously hypertensive rats (SHR's) | 1992 | Journal of medicinal chemistry, Jul-24, Volume: 35, Issue:15
| Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity. |
| AID31885 | Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand. | 1995 | Journal of medicinal chemistry, Mar-31, Volume: 38, Issue:7
| Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
| AID31265 | Functional activity against adenosine A1 receptor from rat atria. | 1995 | Journal of medicinal chemistry, Apr-28, Volume: 38, Issue:9
| 2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists. |
| AID1345685 | Human A1 receptor (Adenosine receptors) | 2002 | Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
| N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. |
| AID1345618 | Human A2A receptor (Adenosine receptors) | 1999 | Biochemical pharmacology, Jan-01, Volume: 57, Issue:1
| Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. |
| AID1345721 | Human A2B receptor (Adenosine receptors) | 2005 | Biochemical pharmacology, Nov-25, Volume: 70, Issue:11
| Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. |
| AID1345822 | Human A3 receptor (Adenosine receptors) | 2002 | Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
| N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. |
| AID1345618 | Human A2A receptor (Adenosine receptors) | 1997 | British journal of pharmacology, Jun, Volume: 121, Issue:3
| Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. |
| AID1345618 | Human A2A receptor (Adenosine receptors) | 2002 | Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
| N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |