Page last updated: 2024-12-06

triazophos

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

triazophos: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID32184
CHEMBL ID1553726
CHEBI ID38963
SCHEMBL ID73598
MeSH IDM0059706

Synonyms (56)

Synonym
methoxone
phosphorothioic acid, o,o-diethyl o-(1-phenyl-1h-1,2,4-triazol-3-yl) ester
triazophos
hoe 2960 oj
o,o-diethyl o-(1-phenyl-1h-1,2,4-triazol-3-yl)phosphorothioate
hsdb 6455
ai3-27764
1-phenyl-3-(o,o-diethyl-thionophosphoryl)-1,2,4-triazole
brn 0682554
hoe 2960
phosphorothioic acid, 0,0-diethyl 0-(1-phenyl-1h-1,2,4-triazol-3-yl) ester
triazofosz (hungarian)
einecs 245-986-5
phosphorothioic acid, o,o-diethyl o-(1-phenyl-1,2,4-triazolyl) ester
triazophos [bsi:iso]
NCGC00163944-02
CHEBI:38963 ,
o,o-diethyl o-(1-phenyl-1h-1,2,4-triazol-3-yl) thiophosphate
hostathion
1-phenyl-1,2,4-triazolyl-3-(o,o-diethylthionophosphate)
o,o-diethyl o-(1-phenyl-1h-1,2,4-triazol-3-yl) phosphorothioate
24017-47-8
triazofos
NCGC00163944-01
C18657
tox21_301578
dtxsid9037612 ,
cas-24017-47-8
dtxcid7017612
NCGC00255454-01
diethoxy-[(1-phenyl-1,2,4-triazol-3-yl)oxy]-sulfanylidene-$l^{5}-phosphane
diethoxy-[(1-phenyl-1,2,4-triazol-3-yl)oxy]-sulfanylidenephosphorane
A817041
unii-6099j8l0ee
6099j8l0ee ,
triazophos 85%
hostation
AKOS015899305
CHEMBL1553726
triazophos [mi]
o,o-diethyl o-1-phenyl-1h-1,2,4-triazol-3-yl phosphorothioate
triazophos [iso]
triazophos [hsdb]
hoe-2960
SCHEMBL73598
AMFGTOFWMRQMEM-UHFFFAOYSA-N
o,o-diethyl o-(1-phenyl-1h-1,2,4-triazol-3-yl) thiophosphate #
trazophos
triazofosz
triazophos, pestanal(r), analytical standard
triazophos 100 microg/ml in acetone
J-015315
triazophos, certified reference material, tracecert(r)
diethoxy-[(1-phenyl-1,2,4-triazol-3-yl)oxy]-sulfanylidene-lambda5-phosphane
Q2452431
triazophos 1000 microg/ml in acetone

Research Excerpts

Overview

Triazophos (TP) is a widespread pollutant in aquatic environments. It inhibits the acetylcholinesterase enzyme and causes paralysis and death of insects.

ExcerptReferenceRelevance
"Triazophos (TP) is a widespread pollutant in aquatic environments. "( Transcriptome analysis reveals sex-specific alterations in gonads of green mussel exposed to organophosphorus insecticide triazophos.
Cai, W; Chen, H; Liu, Y; Zhang, L, 2022
)
2.37
"Triazophos is a commonly used organophosphate insecticide, which inhibits the acetylcholinesterase enzyme and causes paralysis and death of insects. "( Analysis of suppressive effects of pesticide triazophos on leucocyte immune responses in a teleost,
Bhardwaj, AK; Chandra, RK; Tripathi, MK, 2022
)
2.42
"Triazophos is a commonly used organophosphorous insecticide that causes alterations in haematological and histological parameters in fish."( Evaluation of triazophos induced immunotoxicity of spleen and head kidney in fresh water teleost, Channa punctata.
Bhardwaj, AK; Chandra, RK; Tripathi, MK, 2021
)
1.7
"Triazophos (TAP) is a widely used phosphorus pesticide in China that possesses a potential risk for water pollution. "( Triazophos (TAP) removal in horizontal subsurface flow constructed wetlands (HSCWs) and its accumulation in plants and substrates.
Cheng, S; Cui, N; Dai, Y; Li, Z; Wu, J; Wu, L; Zhong, F, 2017
)
3.34
"Triazophos (TAP) is a widely used pesticide that is easily accumulated in the environment due to its relatively high stability: this accumulation from agricultural runoff results in potential hazards to aquatic ecosystems. "( Biological mechanisms associated with triazophos (TAP) removal by horizontal subsurface flow constructed wetlands (HSFCW).
Anderson, B; Cheng, S; Cui, N; Dai, Y; Feng, Y; Wu, J, 2016
)
2.15
"Triazophos is a broad-spectrum and highly effective insecticide, and the residues of triazophos have been frequently detected in the environment. "( Cloning, expression and mutation of a triazophos hydrolase gene from Burkholderia sp. SZL-1.
Cheng, MG; Guo, SH; Hong, Q; Huang, X; Li, Q; Zhang, H; Zhao, MJ, 2016
)
2.15
"Triazophos is a widely used organophosphorous insecticide that has potentially adverse effects to organisms. "( Expression and Functional Properties of an Anti-Triazophos High-Affinity Single-Chain Variable Fragment Antibody with Specific Lambda Light Chain.
Guo, Y; Liang, X; Liu, R; Liu, Y; Xiang, D; Zhu, G, 2016
)
2.13
"Triazophos is a contaminant of wastewater at manufacturing facilities, and remediative treatment may be needed. "( Kinetics and products of photo-Fenton degradation of triazophos.
Chen, M; Deng, Y; Lin, K; Yuan, D, 2004
)
2.02
"Triazophos is a kind of organophosphorous pesticide which was widely used by farmers all over the world in 1990's. "( [Construction of a versatile degrading bacteria Pseudomonas putida KT2440-DOP and its degrading characteristics].
Gu, LF; He, J; Huang, X; Jia, KZ; Li, SP, 2006
)
1.78

Effects

Triazophos (TAP) has been widely used in agriculture for controlling insect pests. It has become a part of widespread pollutant of the aquatic environment due to its residue.

ExcerptReferenceRelevance
"Triazophos (TAP) has become a part of widespread pollutant of the aquatic environment due to its residue. "( Effect of acute exposure of triazophos on histological structure and apoptosis of the brain and liver of zebrafish (Danio rerio).
Gul, Y; Meng, Y; Shao, J; Wang, G; Wu, M; Xiong, D; Yang, H, 2019
)
2.25
"Triazophos (TAP) has been widely used in agriculture for controlling insect pests and is a known organophosphorus pesticide. "( Toxic effects of triazophos on rare minnow (Gobiocypris rarus) embryos and larvae.
Gong, YX; Li, DL; Ling, F; Liu, L; Wang, GX; Wang, Y; Zhu, B, 2014
)
2.18

Toxicity

ExcerptReferenceRelevance
" The toxicological interaction of five organophosphorus pesticides was evaluated using the concentration addition model, the combination index-isobologram equation and the toxic unit approach."( Binary combinations of organophosphorus pesticides exhibit differential toxicity under oxidised and un-oxidised conditions.
Arora, S; Kumar, A, 2015
)
0.42
" These results contribute to the growing knowledge on the effects of insecticidal usage in agriculture on non-target invertebrates, and necessitate the need to explore alternate insecticides that can effectively control insect pests but safe for non-target organisms."( Side effects of insecticidal usage in rice farming system on the non-target house fly Musca domestica in Punjab, Pakistan.
Khan, HAA, 2020
)
0.56
" Toxicity assays of strain Z1 using reporter recombinase gene (recA) and zebrafish showed that there was no accumulation of toxic metabolites during the degradation process."( Simultaneous degradation of triazophos, methamidophos and carbofuran pesticides in wastewater using an Enterobacter bacterial bioreactor and analysis of toxicity and biosafety.
Chen, Z; Wang, G; Xu, Z; Zhang, Y, 2020
)
0.85

Compound-Compound Interactions

ExcerptReferenceRelevance
" In this study, SERS was combined with dispersive liquid-liquid microextraction (DLLME) to develop a rapid and reliable method for the detection of organophosphorus pesticides (OPPs)."( Rapid and reliable detection and quantification of organophosphorus pesticides using SERS combined with dispersive liquid-liquid microextraction.
Li, G; Li, X; Sun, Y; Wang, L; Wang, P; Xu, Y, 2022
)
0.72
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

RoleDescription
EC 3.1.1.7 (acetylcholinesterase) inhibitorAn EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
acaricideA substance used to destroy pests of the subclass Acari (mites and ticks).
agrochemicalAn agrochemical is a substance that is used in agriculture or horticulture.
nematicideA substance used to destroy pests of the phylum Nematoda (roundworms).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
organic thiophosphate
organothiophosphate insecticide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (18)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency35.57420.007215.758889.3584AID1224835
acetylcholinesteraseHomo sapiens (human)Potency35.35750.002541.796015,848.9004AID1347395; AID1347397; AID1347398; AID1347399
phosphopantetheinyl transferaseBacillus subtilisPotency63.09570.141337.9142100.0000AID1490
RAR-related orphan receptor gammaMus musculus (house mouse)Potency17.22890.006038.004119,952.5996AID1159523
AR proteinHomo sapiens (human)Potency39.32550.000221.22318,912.5098AID743054; AID743063
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency18.39800.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency68.58960.000417.946075.1148AID1346795
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency7.94330.000214.376460.0339AID588532
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency34.05060.003041.611522,387.1992AID1159552; AID1159553; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency30.08340.000817.505159.3239AID1159527; AID1159531
pregnane X nuclear receptorHomo sapiens (human)Potency31.39370.005428.02631,258.9301AID1346982; AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency29.18610.000229.305416,493.5996AID743069; AID743079
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency14.81650.001024.504861.6448AID743212; AID743215
aryl hydrocarbon receptorHomo sapiens (human)Potency15.91800.000723.06741,258.9301AID651777; AID743085; AID743122
thyroid stimulating hormone receptorHomo sapiens (human)Potency9.68850.001628.015177.1139AID1224843
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency14.12540.354828.065989.1251AID504847
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency19.95260.00798.23321,122.0200AID2546
Cellular tumor antigen p53Homo sapiens (human)Potency29.46440.002319.595674.0614AID651631; AID651743
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (124)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (34)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (19)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (46)

Assay IDTitleYearJournalArticle
AID1081360Solubility in water2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081358Drug level in Cicer arietinum (chickpea) green seeds measured 100 days post dose following field application at 1 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081362Drug level in Solanum lycopersicum (tomato) roots measured post dose following field application at 1 and 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081337Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as reduction in nematode population measured 110 days post dose following field application at 1 to 2 kg of active ingred2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081361Drug level in Triticum aestivum (wheat) plant roots measured post dose following field application2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081369Drug absorption in Solanum lycopersicum (tomato) roots assessed as mean drug level measured post dose following field application at 1 and 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081355Drug level in Cicer arietinum (chickpea) green seeds measured 100 days post dose following field application at 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081349Drug level in Solanum lycopersicum (tomato) green seeds measured 100 days post dose following field application at 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081344Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 1.8 to2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081324Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 1.38 to2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081341Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 1.8 t2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081333Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested in tomato plants plots assessed as reduction in nematode population measured 55 days post dose following field application at 1 to 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081346Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 2 kg of active ingredient/h2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081371Drug absorption in Solanum lycopersicum (tomato) roots measured 30 days post dose following field application at 1 and 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081359Drug level in Cicer arietinum (chickpea) green seeds measured 90 days post dose following field application at 1 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081348Drug level in Solanum lycopersicum (tomato) green seeds measured 120 days post dose following field application at 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081327Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 1 kg of active ingredient/he2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081343Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 1 kg of active ingredient/2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081353Drug level in Solanum lycopersicum (tomato) green seeds measured 90 days post dose following field application at 1 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081345Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 1.8 to2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081351Drug level in Solanum lycopersicum (tomato) green seeds measured 120 days post dose following field application at 1 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081352Drug level in Solanum lycopersicum (tomato) green seeds measured 100 days post dose following field application at 1 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081350Drug level in Solanum lycopersicum (tomato) green seeds measured 90 days post dose following field application at 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081331Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 1 kg of active ingredient/hec2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081328Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 1.38 to 2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081340Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 1.8 t2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081356Drug level in Cicer arietinum (chickpea) green seeds measured 90 days post dose following field application at 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081325Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 1.38 to2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081366Cmax in Solanum lycopersicum (tomato) shoots measured 45 days post dose following field application at 1 and 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081334Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as reduction in nematode population measured 110 days post dose following field application at 1 to 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081370Drug absorption in Cicer arietinum (chickpea) roots measured 45 days post dose following field application at 1 and 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081332Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as reduction in nematode population measured 110 days post dose following field application at 1 to 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081342Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 2 kg of active ingredient/2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081326Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 2 kg of active ingredient/he2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081368Drug translocation in Solanum lycopersicum (tomato) roots assessed as mean drug level measured post dose following field application at 1 and 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081357Drug level in Cicer arietinum (chickpea) green seeds measured 120 days post dose following field application at 1 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081374Toxicity in Rattus norvegicus (rat)2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081347Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 1 kg of active ingredient/h2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081329Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 1.38 to 2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081363Cmax in Cicer arietinum (chickpea) shoots measured 30 days post dose following field application at 1 and 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081336Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as reduction in nematode population measured 110 days post dose following field application at 1 to 2 kg of active ingredie2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081330Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 2 kg of active ingredient/hec2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081354Drug level in Cicer arietinum (chickpea) green seeds measured 120 days post dose following field application at 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081339Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as reduction in nematode population measured 55 days post dose following field application at 1 to 2 kg of active ingredi2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081335Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as reduction in nematode population measured 55 days post dose following field application at 1 to 2 kg of active ingredient/hectare2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
AID1081338Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as reduction in nematode population measured 55 days post dose following field application at 1 to 2 kg of active ingredien2010Journal of agricultural and food chemistry, Feb-10, Volume: 58, Issue:3
Persistence and nematicidal efficacy of carbosulfan, cadusafos, phorate, and triazophos in soil and uptake by chickpea and tomato crops under tropical conditions.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (135)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (0.74)18.7374
1990's4 (2.96)18.2507
2000's35 (25.93)29.6817
2010's69 (51.11)24.3611
2020's26 (19.26)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.76 (24.57)
Research Supply Index4.93 (2.92)
Research Growth Index5.66 (4.65)
Search Engine Demand Index72.70 (26.88)
Search Engine Supply Index2.70 (0.95)

This Compound (38.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (0.72%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other137 (99.28%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]