| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
phosphoserine
Phosphoserine: The phosphoric acid ester of serine. | 6.96 | 1 | 0 | non-proteinogenic alpha-amino acid;
O-phosphoamino acid;
serine derivative | human metabolite |
aminolevulinic acid
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.. 5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. | 2.01 | 1 | 0 | 4-oxo monocarboxylic acid;
amino acid zwitterion;
delta-amino acid | antineoplastic agent;
dermatologic drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite;
prodrug;
Saccharomyces cerevisiae metabolite |
5-aminovaleric acid
5-aminovaleric acid: from red fox anal secretion; RN given refers to parent cpd. 5-aminopentanoic acid : A delta-amino acid comprising pentanoic acid with an amino substituent at C-5; a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist. | 2.01 | 1 | 0 | amino acid zwitterion;
delta-amino acid;
omega-amino fatty acid | human metabolite |
alanylalanine
alanylalanine: RN given refers to (DL)-isomer | 2.01 | 1 | 0 | dipeptide | |
oxalic acid
Oxalic Acid: A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.. oxalic acid : An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2. | 2 | 1 | 0 | alpha,omega-dicarboxylic acid | algal metabolite;
human metabolite;
plant metabolite |
hydroxyproline
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group. | 1.97 | 1 | 0 | 4-hydroxyproline;
L-alpha-amino acid zwitterion | human metabolite;
mouse metabolite;
plant metabolite |
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2. | 8.51 | 2 | 0 | alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite |
serine
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. | 6.96 | 1 | 0 | L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine. | 1.96 | 1 | 0 | aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid | algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite |
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3. | 6.96 | 1 | 0 | amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite |
valine
Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine. | 2.13 | 1 | 0 | L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite |
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms. | 2.06 | 1 | 0 | diazine;
pyrazines | Daphnia magna metabolite |
glycylglycine
[no description available] | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | human metabolite |
isodesmosine
Isodesmosine: 2-(4-Amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinium. A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.. isodesmosine : A pyridinium ion obtained by formal condensation of four molecules of lysine. | 2.36 | 2 | 0 | lysine derivative;
pyridinium ion | biomarker |
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms. | 2.06 | 1 | 0 | 1,2,3-triazole | |
leucyl-alanine
Leu-Ala : A dipeptide composed of L-leucine and L-alanine joined by a peptide linkage. | 2.01 | 1 | 0 | dipeptide | metabolite |
alanylproline
alanylproline: RN given refers to all (L)-isomer | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
glycylleucine
Gly-Leu : A dipeptide composed of glycine and L-leucine joined by a peptide linkage. | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
alanyltyrosine
alanyltyrosine: tyrosine source; RN given refers to (L)-isomer. Ala-Tyr : A dipeptide composed of L-alanine and L-tyrosine joined by a peptide linkage. | 2.01 | 1 | 0 | dipeptide | metabolite |
glycylsarcosine
glycylsarcosine : A dipeptide obtained by formal condensation of the carboxy group of glycine with the amino group of sarcosine. | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | |
glycylaspartic acid
glycylaspartic acid: RN given refers to (L)-isomer | 2.01 | 1 | 0 | dipeptide | metabolite |
histidylglycine
histidylglycine: RN given refers to all (L)-isomer. His-Gly : A dipeptide formed from L-histidine and glycine residues. | 2.47 | 2 | 0 | dipeptide | metabolite |
lanthionine
lanthionine: a thioether analogue of cystine; RN given refers to (DL)-isomer; structure; a component of lantibiotics (BACTERIOCINS). lanthionine : An alanine derivative in which two alanine residues are linked on their beta-carbons by a thioether linkage. | 8.51 | 2 | 0 | alanine derivative;
non-proteinogenic alpha-amino acid;
organic sulfide | bacterial metabolite |
pyridinoline
pyridinoline: 3-hydroxypyridinium derivative collagen crosslink; structure | 3.06 | 5 | 0 | organonitrogen compound;
organooxygen compound | |
dehydroalanine
2-ammonioprop-2-enoate : An amino acid zwitterion resulting from a transfer of a proton from the carboxy group to the amino group of 2-aminoacrylic acid.. 2-aminoacrylic acid : A 2,3-dehydroamino acid that is alanine which has been dehydrogenated to introduce a double bond between positions 2 and 3. | 2.02 | 1 | 0 | 2,3-dehydroamino acid;
alpha,beta-unsaturated monocarboxylic acid;
amino acid zwitterion;
enamine;
non-proteinogenic alpha-amino acid | alkylating agent;
human metabolite;
mouse metabolite |
alanylglutamic acid
alanylglutamic acid: RN given refers to (L)-isomer. L-alanyl-L-glutamic acid : A dipeptide consisting of L-glutamic acid having an L-alanyl attached to its alpha-amino group | 2.01 | 1 | 0 | dipeptide | |
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2. | 2.05 | 1 | 0 | amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid | algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite |
prolyl-tyrosine
prolyl-tyrosine: structure given in first source. Pro-Tyr : A dipeptide formed from L-proline and L-tyrosine residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
histidylleucine
His-Leu : A dipeptide formed from L-histidine and L-leucine residues. | 2.05 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
prolylglutamic acid
Pro-Glu : A dipeptide formed from L-proline and L-glutamic acid residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
elastin
[no description available] | 1.97 | 1 | 0 | oligopeptide | |
cysteinylglycine
cysteinylglycine: RN given refers to (L)-isomer; RN for cpd without isomeric designation not in Chemlne 7/13/83. L-cysteinylglycine : A dipeptide consisting of glycine having an L-cysteinyl attached to its alpha-amino group. It is an intermediate metabolite in glutathione metabolism. | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite |
aspartyl-aspartic acid
aspartyl-aspartic acid: do not confuse with cyclo(Asp-Asp). Asp-Asp : A dipeptide formed from two L-aspartic acid units. | 2.01 | 1 | 0 | dipeptide | Mycoplasma genitalium metabolite |
glycylproline
Gly-Pro : A dipeptide consisting of L-proline having a glycyl residue attached to its alpha-amino group. | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
seryl-proline
Ser-Pro : A dipeptide formed from L-serine and L-proline residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
phenylalanylalanine
phenylalanylalanine: RN given refers to (L)-isomer. Phe-Ala : A dipeptide formed from L-phenylalanine and L-alanine residues. | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
acetylalanylalanine
acetylalanylalanine: RN given refers to (D)-isomer | 2.01 | 1 | 0 | | |
alpha-aspartylalanine
alpha-aspartylalanine: found in pig brain. Asp-Ala : A dipeptide formed from L-alpha-aspartyl and L-valine residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
alanyltyrosine
Tyr-Ala : A dipeptide formed from L-tyrosine and L-alanine residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
prolylglycine
prolylglycine: RN given refers to (L)-isomer. L-prolylglycine : A dipeptide consisting of glycine having an L-prolyl group attached to its alpha-amino nitrogen. | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | |
glutamylalanine
Glu-Ala : A dipeptide formed from L-alpha-glutamyl and L-alanine residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
phenylalanylphenylalanine
Phe-Phe : A dipeptide formed from two L-phenylalanine residues. | 2.01 | 1 | 0 | dipeptide;
L-aminoacyl-L-amino acid zwitterion | human blood serum metabolite;
Mycoplasma genitalium metabolite |
phenylalanyl-valine
Val-Phe : A dipeptide formed from L-valine and L-phenylalanine residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
alanylglycine
[no description available] | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
valyltyrosine
valyltyrosine: from sardine muscle hydrolyzate. Val-Tyr : A dipeptide formed from L-valine and L-tyrosine residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
phenylalanylproline
Phe-Pro : A dipeptide formed from L-phenylalanine and L-proline residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
glycylhistidine
glycylhistidine: RN given refers to (L)-isomer. Gly-His : A dipeptide composed of glycine and L-histidine joined by a peptide linkage. | 2.41 | 2 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
prolyl-serine
Pro-Ser : A dipeptide formed from L-proline and L-serine residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
prolylvaline
Val-Pro : A dipeptide formed from L-valine and L-proline residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
sitagliptin phosphate
Sitagliptin Phosphate: A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES. | 2.06 | 1 | 0 | | |
desmosine
Desmosine: A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring. | 2.36 | 2 | 0 | aromatic amino acid | |
glucagon
Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511). glucagon : A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence. | 2.06 | 1 | 0 | peptide hormone | |
caseins
Caseins: A mixture of related phosphoproteins occurring in milk and cheese. The group is characterized as one of the most nutritive milk proteins, containing all of the common amino acids and rich in the essential ones. | 2 | 1 | 0 | | |
folic acid
folcysteine: used to promote fertility in chickens. vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin. | 2.08 | 1 | 0 | folic acids;
N-acyl-amino acid | human metabolite;
mouse metabolite;
nutrient |