Page last updated: 2024-08-05 13:37:40

N-acylazetidine

null

ChEBI ID: 46959

Members (3)

MemberDefinitionRole
AZD1979A carboxamide resulting from the formal condensation of the carboxy group of 5-(p-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylic acid with the amino group of 3-phenoxyazetidine and in which the phenoxy group has been substituted at the para- position by a 2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl group. It is a melanin concentrating hormone receptor 1 (MCHr1) antagonist.AZD1979
delgocitinibA pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a (3S,4R)-1-(cyanoacetyl)-3-methyl-1,6-diazaspiro[3.4]octan-6-yl group at position 4. It is a pan-Janus kinase (JAK) inhibitor and is approved for treatment of atopic dermatitis (AD) in Japan.delgocitinib
gdc-0973A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.cobimetinib

Research

Studies (243)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's149 (61.32)24.3611
2020's94 (38.68)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials50 (20.16%)5.53%
Reviews26 (10.48%)6.00%
Case Studies57 (22.98%)4.05%
Observational2 (0.81%)0.25%
Other113 (45.56%)84.16%