triazoles has been researched along with Alzheimer Disease in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.28) | 18.2507 |
| 2000's | 8 (10.26) | 29.6817 |
| 2010's | 36 (46.15) | 24.3611 |
| 2020's | 33 (42.31) | 2.80 |
| Authors | Studies |
|---|---|
| Babaei, P; Badrikoohi, M; Esmaeili-Bandboni, A | 1 |
| Alves, D; Fronza, MG; Praticò, D; Sacramento, M; Savegnago, L | 2 |
| Prasanna, CAL; Sharma, A | 1 |
| Hwang, JH; Kang, Y; Kim, H; Lee, JU; Mun, SK; Oh, JM; Park, JH; Shin, WH; Yee, ST | 1 |
| Bharate, SB; Bhatt, S; Nandi, U; Nuthakki, VK; Sharma, A; Sharma, M | 1 |
| Chen, H; Jiang, X; Liu, W; Liu, X; Tian, L; Wang, N; Wu, L; Wu, Q; Wu, Z; Xu, Z; Zhao, C; Zhao, Q | 1 |
| Bouissane, L; Catto, M; Eddahmi, M; Hafid, A; Khouili, M; La Spada, G | 1 |
| Goyal, B; Goyal, D; Kaur, A; Mann, S; Priyadarshi, N; Singhal, NK | 2 |
| Fazylov, SD; Khlebnikov, AI; Kishkentaeva, AS; Nurkenov, OA; Nurmaganbetov, ZS; Quinn, MT; Schepetkin, IA; Seilkhanov, TM; Shults, EE | 1 |
| Kawada, T | 1 |
| Bateman, RJ; Lucey, BP | 1 |
| Chen, X; Han, L; He, S; Li, Q; Liang, J; Liao, Q; Qi, S; Tian, Y; Xing, S | 1 |
| Bedi, PMS; Chadha, R; Kaur, J; Kaur, R; Kaur, U; Sharma, A; Singh, A; Singh, K | 1 |
| Bliwise, D; Budd, K; Ceesay, P; Herring, WJ; Hutzelmann, J; Lines, C; Michelson, D; Snyder, E; Stevens, J | 1 |
| Cai, HY; He, YX; Li, YY; Qi, JS; Wang, C; Wang, ZJ; Wu, MN; Yan, XD; Zhang, J; Zhou, F | 1 |
| Hou, Z; Huang, XX; Liu, Q; Shi, S; Song, SJ; Wang, H; Wang, J; Wang, Y; Xue, X; Yao, GD; Zhao, H | 1 |
| Duan, HC; Gan, Y; Hu, JP; Hu, YC; Liang, L; Liu, W; Liu, XY; Luo, Q; Peng, LX; Shi, HB; Sun, X; Wan, H; Zhao, G | 1 |
| Castro, NG; Dardenne, LE; de Azevedo, LL; de Freitas Silva, M; Fonseca Nadur, N; Gontijo, VS; Guedes, IA; Guimarães, MJR; Kümmerle, AE; M R da Silva, F; Pruccoli, L; Tardelli Lima, E; Tarozzi, A; Viegas, C | 1 |
| Dang Thi, TA; Le-Nhat-Thuy, G; Nguyen Hoang, S; Nguyen Thi, H; Nguyen Thi, N; Nguyen Thi, TH; Nguyen, TV; Pham-The, H | 1 |
| Arora, S; Attri, S; Bhagat, K; Kaur Gulati, H; Kaur, P; Kumar, N; Mohinder Singh Bedi, P; Sharma, S; Singh, A; Singh, H; Vir Singh, J | 1 |
| McCleery, J; Sharpley, AL | 1 |
| Aras, A; Atalar, MN; Çelik, F; Kahriman, N; Karaman, HS; Türkan, F; Ünver, Y | 1 |
| Chauthong, N; Jiaranaikulwanitch, J; Jiranusornkul, S; Nilkosol, S; Pandith, H; Tadtong, S; Thammarat, P; Vajragupta, O | 1 |
| Agarwal, G; Dalvi, T; Dewangan, B; Jain, A; Sahu, B; Shinde Suchita, D; Srivastava, A | 1 |
| Dodero, VI; Hericks, L; Kaffy, J; Kracker, O; Krzemieniecki, R; Laakkonen, P; Le Joncour, V; Marion, A; Ongeri, S; Schröder, DC; Sewald, N; Tonali, N | 1 |
| Chen, S; Chen, X; Fang, L; Li, Z; Liu, T; Wang, M; Zhang, Y; Zheng, Y | 1 |
| Huang, W; Huang, Y; Ma, L; Wang, R; Yang, G | 1 |
| Bartolomé, F; Carro, E; Cuevas, EP; García-Rubia, A; Martínez, A; Nozal, V; Palomo, V; Pérez, C; Ramírez, D; Tosat-Bitrián, C | 1 |
| Bliwise, D; Budd, K; Ceesay, P; Ceren, O; Herring, WJ; Hutzelmann, J; Lines, C; Michelson, D; Snyder, E; Stevens, J; Svetnik, V; Wang, TC | 1 |
| Benito, E; Burkhardt, S; Capece, V; Dean, C; Fischer, A; Ramachandran, B; Schmidt, G; Schroeder, H; Urbanke, H | 1 |
| Edraki, N; Firuzi, O; Iraji, A; Khoshneviszadeh, M; Mahdavi, M; Miri, R; Nadri, H; Tavakkoli, M | 1 |
| Hamuro, A; Honda, M; Wakaura, Y | 1 |
| Karahan, H; Kelicen-Uğur, P; Lüle, S | 1 |
| Akbarzadeh, T; Edraki, N; Karimpour-Razkenari, E; Khanavi, M; Mahdavi, M; Najafi, Z; Saeedi, M; Sharifzadeh, M | 1 |
| Ballatore, C; Brunden, KR; Cornec, AS; James, MJ; Koivula, P; Lee, VM; Oukoloff, K; Smith, AB; Trojanowski, JQ; Yao, Y; Zhang, B | 1 |
| Akbarzadeh, T; Edraki, N; Larijani, B; Mahdavi, M; Mirfazli, SS; Moghadam, FH; Moradi, A; Nadri, H; Rastegari, A; Saeedi, M | 1 |
| Abu-Serie, MM; AlFadly, ED; Bakkar, NZ; Bartolini, M; Belal, ASF; El-Yazbi, AF; Elkazaz, S; Elzahhar, PA; Ghareeb, DA; Iriepa, I; Janockova, J; Kobeissy, F; Moraleda, I; Rafeh, RW; Saudi, MNS; Shaltout, H; Soukup, O; Tramarin, A | 1 |
| Goyal, B; Goyal, D; Narang, SS | 1 |
| Alves, D; Baldinotti, R; Begnini, K; Collares, T; Dalberto, BT; Fronza, MG; Goldani, B; Kremer, FS; Lenardão, EJ; Martins, MC; Pinto, LDS; Savegnago, L; Seixas, FK | 1 |
| Badri, R; Edraki, N; Firuzi, O; Iraji, A; Khoshneviszadeh, M; Yazdani, M | 1 |
| Ji, J; Peng, Y; Rakesh, KP; Wang, S; Xu, M; Zhu, L | 1 |
| Berthelot, D; Bischoff, FP; De Cleyn, MA; Gijsen, HJ; Jaroskova, L; Macdonald, G; Mercken, M; Oehlrich, D; Rombouts, FJ; Surkyn, M; Trabanco, AA; Tresadern, G; Van Brandt, S; Velter, AI; Wu, T | 1 |
| Amini, M; Atyabi, F; Dinarvand, R; Kamalinia, G; Khodagholi, F; Shaerzadeh, F; Sharifzadeh, M | 1 |
| Albasanz, JL; Barrachina, M; Blanch, M; Díaz-Sánchez, S; Ferrer, I; Martín, M; Monje, A; Pereira-Veiga, T; Planchat, LM; Villar-Menéndez, I | 1 |
| Chang, RC; Chiu, K; Chu, LW; Ho, YS; Hung, CH; Lau, CF; Poon, CH; Wuwongse, S; Yang, X | 1 |
| Amini, M; Atyabi, F; Chaharband, F; Dinarvand, R; Kamalinia, G; Khodagholi, F; Shaerzadeh, F; Sharifzadeh, M; Tavssolian, F | 1 |
| Hayama, T; Kamata, M; Kondo, S; Maeda, R; Murakami, K; Watanabe, T | 1 |
| Igari, T; Kamata, M; Koike, T; Kondo, S; Murakami, K; Watanabe, T | 1 |
| Cardoso, CL; Carvalho, I; Chierrito, TP; Mantoani, SP; Martínez, A; Vilela, AF | 1 |
| Ballatore, C; Brunden, KR; Cornec, AS; Crowe, A; James, M; Kovalevich, J; Lee, VM; Smith, AB; Trojanowski, JQ; Yao, Y | 1 |
| Faghihi, MA; Magistri, M; Makhmutova, M; Patel, P; Sartor, GC; Velmeshev, D; Volmar, CH; Wahlestedt, C | 1 |
| Gyoneva, S; Swanger, SA; Traynelis, SF; Weinshenker, D; Zhang, J | 1 |
| Bethge, P; Blanchet, C; Cunha, RA; Frick, A; Gonçalves, FQ; Gonçalves, N; Gorlewicz, A; Grosjean, N; Haberl, MG; Lemos, C; Malezieux, M; Mulle, C; Nägerl, UV; Viana da Silva, S; Zhang, P | 1 |
| Akbarzadeh, T; Asatouri, R; Karimpour-Razkenari, E; Khanavi, M; Mahdavi, M; Moghadam, FH; Najafi, Z; Saeedi, M; Sharifzadeh, M; Vafadarnejad, F | 1 |
| Akbarzadeh, T; Edraki, N; Karimpour-Razkenari, E; Khanavi, M; Mahdavi, M; Moghadam, FH; Saeedi, M; Safavi, M | 1 |
| Adcott, J; Bertrand, HC; Callard, R; Castillo-Quan, JI; Cochemé, HM; Gatliff, J; Gomez Perez-Nievas, B; Ivanov, DK; Kerr, F; Khericha, M; Martinez, P; Noble, W; Partridge, L; Snoeren, I; Sofola-Adesakin, O; Thornton, J; Wells, G | 1 |
| Canas, PM; Cunha, GM; Cunha, RA; Machado, NJ; Oliveira, CR; Oliveira, JM; Porciúncula, LO; Silva, CG | 1 |
| Abbatecola, AM; D'Amico, M; Di Filippo, C; Ferraraccio, F; Marfella, R; Paolisso, G; Rossi, F | 1 |
| Liu, G; Men, P; Perry, G; Smith, MA | 1 |
| Alonso, A; Brown, CM; Dzyuba, SV; Smith, NW | 1 |
| Borgia, JA; Mufson, EJ; Overk, CR | 1 |
| Carlier, PR; Hirata-Fukae, C; Lam, PC; Matsuoka, Y; Monceaux, CJ; Totrov, MM | 1 |
| Choi, J; Lu, PY; Mufson, EJ; Overk, CR; Shaw, JW; Thatcher, GR; Wang, YT | 1 |
| Almansour, AI; Arumugam, N; Ashraf Ali, M; Choon, TS; Elumalai, K; Ismail, R; Kumar, RS; Osman, H; Singh, A | 1 |
| Huh, JW; Jang, M; Kim, DH; Kim, TW; Park, JS; Suh, JH; Yoon, SY | 1 |
| Aota, M; Doihara, H; Harada, K; Matsuoka, N; Morita, M; Nakato, K; Ni, K; Saita, K; Sato, Y; Takahashi, S; Yamaji, T; Yamazaki, M; Yarimizu, J | 1 |
| Fokin, VV; Govitrapong, P; Jiaranaikulwanitch, J; Vajragupta, O | 1 |
| Cunha, RA; Dall'Igna, OP; Dall'lgna, OP; Lara, DR; Porciúncula, LO; Souza, DO | 1 |
| Nawrot, M | 1 |
| Cunha, RA; Dall'Igna, OP; Fett, P; Gomes, MW; Lara, DR; Souza, DO | 1 |
| Adès, D; Garnier-Suillerot, A; Le Moyec, L; Migonney, V; Saengkhae, C; Salerno, M; Siove, A | 1 |
| Waugh, WH | 1 |
| Hou, C; Kung, HF; Kung, MP; Oya, S; Qu, W | 1 |
| Albasanz, JL; Barrachina, M; Ferrer, I; Martín, M; Perez, S | 1 |
| Bromidge, S; Hawkins, J; Jenkins, SM; Orlek, BS; Riley, GJ; Wadsworth, HJ; Wyman, PA | 1 |
8 review(s) available for triazoles and Alzheimer Disease
| Article | Year |
|---|---|
Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer's Disease: An Overview.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Humans; Oxidative Stress; Triazoles | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
Review of triazole scaffolds for treatment and diagnosis of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Humans; Ligands; Protein Binding; Triazoles | 2023 |
Pathogenesis of Alzheimer's Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential.
Topics: Alzheimer Disease; Amyloidogenic Proteins; Calcium; Glutamic Acid; Humans; Triazoles | 2023 |
The Advances of the Structure and Function of Indoleamine 2, 3- dioxygenase 1 and Its Inhibitors.
Topics: Alzheimer Disease; Antineoplastic Agents; Depression; Drug Design; Enzyme Inhibitors; Gene Expression; Histocompatibility, Maternal-Fetal; Humans; Imidazoles; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Neoplasms; Neuroprotective Agents; Signal Transduction; Structure-Activity Relationship; Triazoles; Tumor Escape | 2020 |
Pharmacotherapies for sleep disturbances in dementia.
Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Sleep; Sleep Wake Disorders; Time Factors; Trazodone; Triazoles | 2020 |
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Structure-Activity Relationship; Triazoles | 2019 |
Disorders of motion and depth.
Topics: Alzheimer Disease; Amblyopia; Antidepressive Agents; Cerebral Veins; Cues; Depth Perception; Epilepsy; Humans; Mesencephalon; Motion Perception; Occipital Lobe; Perceptual Disorders; Piperazines; Schizophrenia; Sinus Thrombosis, Intracranial; Temporal Lobe; Triazoles; Vestibular Diseases; Williams Syndrome | 2003 |
4 trial(s) available for triazoles and Alzheimer Disease
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial.
Topics: Aged; Alzheimer Disease; Azepines; Female; Humans; Male; Polysomnography; Sleep; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Triazoles | 2020 |
Pilot evaluation of a consumer wearable device to assess sleep in a clinical polysomnography trial of suvorexant for treating insomnia in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Azepines; Humans; Pilot Projects; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Wearable Electronic Devices | 2021 |
Suvorexant for the treatment of insomnia in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Azepines; Female; Humans; Male; Orexin Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Treatment Outcome; Triazoles | 2018 |
67 other study(ies) available for triazoles and Alzheimer Disease
| Article | Year |
|---|---|
Simultaneous administration of bromodomain and histone deacetylase I inhibitors alleviates cognition deficit in Alzheimer's model of rats.
Topics: Alzheimer Disease; Animals; Azepines; Behavior, Animal; Benzamides; CREB-Binding Protein; Disease Models, Animal; Drug Therapy, Combination; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Male; Memory Disorders; Nuclear Proteins; Pyridines; Random Allocation; Rats; Rats, Wistar; Transcription Factors; Triazoles; Tumor Necrosis Factor-alpha | 2022 |
1-(7-Chloroquinolin-4-yl)-N-(4-Methoxybenzyl)-5-Methyl-1H-1,2, 3-Triazole-4- carboxamide Reduces Aβ Formation and Tau Phosphorylation in Cellular Models of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Glycogen Synthase Kinase 3 beta; Humans; Phosphorylation; Quinolines; tau Proteins; Triazoles | 2022 |
Synthesis of 4-substituted benzyl-2-triazole-linked-tryptamine-paeonol derivatives and evaluation of their selective inhibitions against butyrylcholinesterase and monoamine oxidase-B.
Topics: Acetophenones; Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Structure-Activity Relationship; Triazoles; Tryptamines | 2022 |
Design, synthesis, and structure-activity relationship of caffeine-based triazoles as dual AChE and BACE-1 inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Biological Products; Caffeine; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles | 2022 |
Discovery of novel β-carboline-1,2,3-triazole hybrids as AChE/GSK-3β dual inhibitors for Alzheimer's disease treatment.
Topics: Acetylcholinesterase; Alzheimer Disease; Carbolines; Cholinesterase Inhibitors; Glycogen Synthase Kinase 3 beta; Humans; Neuroblastoma; Phosphorylation; tau Proteins; Triazoles | 2022 |
Towards Alzheimer's disease-related targets: One-pot Cu(I)- mediated synthesis of new nitroindazolyltriazoles.
Topics: Alzheimer Disease; Amyloidogenic Proteins; Brain; Catalysis; Cholinesterases; Copper; Indazoles; Monoamine Oxidase; Triazoles | 2023 |
QTC-4-MeOBnE Ameliorated Depressive-Like Behavior and Memory Impairment in 3xTg Mice.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Depressive Disorder, Major; Disease Models, Animal; Hippocampus; Memory Disorders; Mice; Mice, Transgenic; Neuroinflammatory Diseases; tau Proteins; Triazoles | 2023 |
Triazole-Peptide Conjugate as a Modulator of Aβ-Aggregation, Metal-Mediated Aβ-Aggregation, and Cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Metals; Molecular Dynamics Simulation; Neuroblastoma; Peptide Fragments; Triazoles | 2023 |
Inhibition of Acetylcholinesterase by Novel Lupinine Derivatives.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Humans; Kinetics; Molecular Docking Simulation; Neurodegenerative Diseases; Structure-Activity Relationship; Triazoles | 2023 |
Suvorexant for Preventing Alzheimer's Disease.
Topics: Alzheimer Disease; Azepines; Humans; Sleep Initiation and Maintenance Disorders; Triazoles | 2023 |
Reply to Suvorexant for Preventing Alzheimer's Disease.
Topics: Alzheimer Disease; Azepines; Humans; Triazoles | 2023 |
Suvorexant ameliorates cognitive impairments and pathology in APP/PS1 transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Azepines; Chronobiology Disorders; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Gene Expression; Hippocampus; Long-Term Potentiation; Mice, Transgenic; Neuronal Plasticity; Neuroprostanes; Orexin Receptor Antagonists; Orexins; Triazoles | 2020 |
Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Cinnamates; Drug Design; Flavones; Humans; Molecular Docking Simulation; Neuroprotective Agents; Oxidative Stress; Protein Aggregates; Protein Aggregation, Pathological; Triazoles | 2020 |
Design, Synthesis and Biological Evaluation of Novel Triazole
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cells, Cultured; Cholinesterase Inhibitors; Curcumin; Humans; Neurons; Neuroprotective Agents; Pharmacokinetics; Reactive Oxygen Species; Resveratrol; Triazoles | 2020 |
Synthesis and biological evaluation of novel quinazoline-triazole hybrid compounds with potential use in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acid Sequence; Catalytic Domain; Cholinesterase Inhibitors; Click Chemistry; Drug Evaluation, Preclinical; Humans; Molecular Docking Simulation; Protein Conformation; Quinazolines; Structure-Activity Relationship; Triazoles | 2020 |
New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cholinesterase Inhibitors; Coumarins; Dose-Response Relationship, Drug; Humans; Molecular Structure; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship; Triazoles | 2020 |
Synthesis of novel 1,2,3 triazole derivatives and assessment of their potential cholinesterases, glutathione S-transferase enzymes inhibitory properties: An in vitro and in silico study.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Enzyme Inhibitors; Glutathione Transferase; Humans; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship; Triazoles | 2021 |
Novel Multifunctional Ascorbic Triazole Derivatives for Amyloidogenic Pathway Inhibition, Anti-Inflammation, and Neuroprotection.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Animals; Anti-Inflammatory Agents; Ascorbic Acid; Binding Sites; Blood-Brain Barrier; Cells, Cultured; Computer Simulation; Cyclooxygenase 2; Gene Expression; Humans; Mice; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Sodium-Coupled Vitamin C Transporters; Structure-Activity Relationship; Triazoles | 2021 |
Design, synthesis and in-vitro evaluation of fluorinated triazoles as multi-target directed ligands for Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Dose-Response Relationship, Drug; Drug Design; Halogenation; Humans; Ligands; Molecular Structure; Protein Aggregates; Reactive Oxygen Species; Structure-Activity Relationship; Triazoles | 2021 |
Peptidotriazolamers Inhibit Aβ(1-42) Oligomerization and Cross a Blood-Brain-Barrier Model.
Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Blood-Brain Barrier; Cell Survival; Humans; Models, Biological; Models, Molecular; Molecular Conformation; Molecular Structure; Peptide Fragments; Peptides; Protein Aggregates; Protein Binding; Structure-Activity Relationship; Triazoles | 2021 |
Discovery of 7-O-1, 2, 3-triazole hesperetin derivatives as multi-target-directed ligands against Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Discovery; Hesperidin; Ligands; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Neuroprotective Agents; Nitric Oxide; Protein Binding; Rats; Transcription Factor RelA; Triazoles | 2021 |
Design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents.
Topics: Alzheimer Disease; Animals; Cell Line; Diosgenin; Dose-Response Relationship, Drug; Drug Design; Inflammation; Lipopolysaccharides; Molecular Conformation; Neuroprotective Agents; Nitric Oxide; Rats; Structure-Activity Relationship; Triazoles | 2021 |
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line; Enzyme Inhibitors; Humans; Ligands; Molecular Structure; Neuroprotective Agents; Triazoles | 2021 |
The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Azepines; Behavior, Animal; Chromosomal Proteins, Non-Histone; Gene Expression; Hippocampus; Long-Term Potentiation; Male; Memory; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Proteins; Transcription Factors; Triazoles | 2017 |
Multifunctional iminochromene-2H-carboxamide derivatives containing different aminomethylene triazole with BACE1 inhibitory, neuroprotective and metal chelating properties targeting Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Benzopyrans; Cell Proliferation; Chelating Agents; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; PC12 Cells; Rats; Structure-Activity Relationship; Triazoles | 2017 |
Aromatase/Seladin-1 Interactions in Human Neuronal Cell Culture, the Hippocampus of Healthy Rats and Transgenic Alzheimer's Disease Mice.
Topics: Alzheimer Disease; Androstenes; Animals; Aromatase; Aromatase Inhibitors; Cells, Cultured; Dentate Gyrus; Female; Hippocampus; Humans; Infusions, Intraventricular; Letrozole; Male; Mice; Mice, Knockout; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Rats; Triazoles | 2018 |
Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer's compounds: In vitro and in vivo biological evaluation and docking study.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Cholinesterase Inhibitors; Coumarins; Humans; Male; Maze Learning; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; Nootropic Agents; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Tacrine; Torpedo; Triazoles | 2019 |
A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.
Topics: Alzheimer Disease; Animals; Axonal Transport; Axons; Brain; Disease Models, Animal; Humans; Mice; Microtubules; Neurons; Quinazolines; tau Proteins; Tauopathies; Triazoles | 2018 |
Design, synthesis and anti-Alzheimer's activity of novel 1,2,3-triazole-chromenone carboxamide derivatives.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Apoptosis; Catalytic Domain; Chelating Agents; Cholinesterase Inhibitors; Coumarins; Drug Design; Hydrogen Peroxide; Metals, Heavy; Molecular Docking Simulation; Neuroprotective Agents; PC12 Cells; Rats; Torpedo; Triazoles | 2019 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Neurons; PC12 Cells; Rats; Semicarbazides; Triazoles | 2019 |
Multi-target-directed triazole derivatives as promising agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Copper; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Structure-Activity Relationship; Triazoles | 2019 |
Inhibition of Alzheimer's amyloid-β
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Carbolines; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Neurodegenerative Diseases; Peptide Fragments; Triazoles | 2020 |
Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognition; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Mice; Molecular Docking Simulation; Neuroprotective Agents; Quinolines; Streptozocin; Triazoles | 2019 |
5,6-Diphenyl triazine-thio methyl triazole hybrid as a new Alzheimer's disease modifying agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Aspartic Acid Endopeptidases; Catalytic Domain; Cholinesterase Inhibitors; Drug Design; Molecular Docking Simulation; Structure-Activity Relationship; Triazines; Triazoles | 2020 |
Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dogs; Drug Design; Humans; Mice; Microsomes, Liver; Models, Molecular; Piperidines; Triazoles | 2013 |
Enhanced brain delivery of deferasirox-lactoferrin conjugates for iron chelation therapy in neurodegenerative disorders: in vitro and in vivo studies.
Topics: Alzheimer Disease; Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzoates; Brain; Carbodiimides; Cell Line, Tumor; Chelating Agents; Chelation Therapy; Deferasirox; Disease Models, Animal; Drug Delivery Systems; Iron; Lactoferrin; Male; Nanostructures; Neurodegenerative Diseases; Neuroprotective Agents; PC12 Cells; Permeability; Rats; Rats, Wistar; Transcytosis; Triazoles | 2013 |
Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia.
Topics: Actins; Adenosine A1 Receptor Antagonists; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cell Membrane; DNA Methylation; Female; Humans; Lewy Body Disease; Male; Middle Aged; Positron-Emission Tomography; Postmortem Changes; Psychiatric Status Rating Scales; Putamen; Receptor, Adenosine A2A; Schizophrenia; Triazines; Triazoles; Tritium; Xanthines | 2014 |
Protective effects of testosterone on presynaptic terminals against oligomeric β-amyloid peptide in primary culture of hippocampal neurons.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Hippocampus; Humans; Letrozole; Neurons; Nitriles; Presynaptic Terminals; Primary Cell Culture; Protective Agents; Rats; Testosterone; Triazoles | 2014 |
Cationic albumin-conjugated chelating agent as a novel brain drug delivery system in neurodegeneration.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Benzoates; Brain; Cations; Deferasirox; Drug Carriers; Drug Delivery Systems; Humans; Iron Chelating Agents; Male; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Rats, Wistar; Serum Albumin; Triazoles | 2015 |
Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Cognition; Cognition Disorders; Disease Models, Animal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Neuroprotective Agents; Patch-Clamp Techniques; Pyridines; Triazoles | 2016 |
Pharmacological properties of a novel and potent γ-secretase modulator as a therapeutic option for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Brain; Cognition; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Pyridines; Real-Time Polymerase Chain Reaction; Triazoles | 2016 |
Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Catalytic Domain; Cholinesterase Inhibitors; Click Chemistry; Humans; Kinetics; Molecular Docking Simulation; Protein Binding; Quinolines; Triazoles | 2016 |
Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies.
Topics: Alzheimer Disease; Animals; Biological Availability; Blood-Brain Barrier; Cell Division; Dose-Response Relationship, Drug; Female; Hydrocarbons, Halogenated; Male; Mice; Microtubules; Neurons; Proteasome Endopeptidase Complex; Pyrimidines; tau Proteins; Tauopathies; Triazoles; Tubulin | 2016 |
The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Azepines; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Inflammation; Learning; Male; Memory; Mice, Transgenic; Neuroprotective Agents; Organ Size; Peptide Fragments; Phosphorylation; Spleen; tau Proteins; Triazoles | 2016 |
Altered motility of plaque-associated microglia in a model of Alzheimer's disease.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Animals; Cell Movement; Disease Models, Animal; Hippocampus; Humans; Immunohistochemistry; Mice, Transgenic; Microglia; Microscopy, Confocal; Neuroimmunomodulation; Plaque, Amyloid; Pyrimidines; Receptor, Adenosine A2A; Tissue Culture Techniques; Triazoles | 2016 |
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; CA3 Region, Hippocampal; Dendritic Spines; Disease Models, Animal; Gene Expression Regulation; Humans; Long-Term Potentiation; Memory, Episodic; Mice; Mice, Transgenic; Neuroprotective Agents; Presenilin-1; Pyrimidines; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Signal Transduction; Synapses; Triazines; Triazoles | 2016 |
Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Death; Cell Line; Cell Line, Tumor; Cholinesterase Inhibitors; Humans; Kinetics; Male; Memory Disorders; Molecular Docking Simulation; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Structure-Activity Relationship; Tacrine; Triazoles | 2017 |
Synthesis of novel chromenones linked to 1,2,3-triazole ring system: Investigation of biological activities against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Benzopyrans; Cell Death; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Neuroprotective Agents; PC12 Cells; Rats; Triazoles | 2017 |
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Gene Expression Profiling; Glycogen Synthase Kinase 3; Humans; Kelch-Like ECH-Associated Protein 1; Lithium Chloride; Longevity; Mice; Microscopy, Confocal; Neurons; NF-E2-Related Factor 2; Oleanolic Acid; Peptide Fragments; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Thiadiazoles; Triazoles | 2017 |
Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Caffeine; Cell Survival; Cells, Cultured; Down-Regulation; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphorylation; Presynaptic Terminals; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Synaptic Membranes; Triazoles | 2009 |
Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Memory Disorders; Mice; Mice, Transgenic; Motor Activity; Pyrazines; Sitagliptin Phosphate; Triazoles | 2010 |
Nanoparticle and iron chelators as a potential novel Alzheimer therapy.
Topics: Aged; Alzheimer Disease; Benzoates; Blood-Brain Barrier; Brain; Chelation Therapy; Deferasirox; Deferoxamine; Drug Carriers; Ferritins; Humans; Iron; Iron Chelating Agents; Metals; Molecular Structure; Nanoparticles; Triazoles | 2010 |
Triazole-containing BODIPY dyes as novel fluorescent probes for soluble oligomers of amyloid Abeta1-42 peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Boron Compounds; Fluorescent Dyes; Humans; Peptide Fragments; Protein Conformation; Triazoles | 2010 |
A novel approach for long-term oral drug administration in animal research.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Protein Precursor; Anastrozole; Animal Experimentation; Animals; Antipsychotic Agents; Body Weight; Chromatography, Liquid; Disease Models, Animal; Female; Gels; Humans; Mass Spectrometry; Mice; Mice, Transgenic; Nitriles; Presenilin-1; Reproducibility of Results; tau Proteins; Triazoles | 2011 |
Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors.
Topics: Alzheimer Disease; Amides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Catalytic Domain; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Oxidation-Reduction; Small Molecule Libraries; Triazoles | 2011 |
Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anastrozole; Animals; Aromatase Inhibitors; Disease Models, Animal; Female; Hippocampus; Male; Mice; Mice, Transgenic; Neurons; Nitriles; Orchiectomy; Ovariectomy; Plaque, Amyloid; Triazoles | 2012 |
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Topics: Acetylcholinesterase; Alzheimer Disease; Azo Compounds; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Indoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Piperidines; Spiro Compounds; Structure-Activity Relationship; Temperature; Thiazoles; Thiosemicarbazones; Triazoles | 2012 |
Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures.
Topics: Alzheimer Disease; Animals; Diabetes Complications; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Hippocampus; Male; Neurons; Phosphorylation; Primary Cell Culture; Pyrazines; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Sitagliptin Phosphate; tau Proteins; Triazoles | 2012 |
A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Animals; Brain; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine Plasma Membrane Transport Proteins; Humans; Inhibitory Concentration 50; Male; Memory Disorders; Mice; Oxadiazoles; Permeability; Rats; Rats, Wistar; Schizophrenia; Triazoles | 2012 |
From BACE1 inhibitor to multifunctionality of tryptoline and tryptamine triazole derivatives for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid Endopeptidases; Binding Sites; Biological Assay; Carbolines; Chelating Agents; Humans; Models, Molecular; Protease Inhibitors; Protective Agents; Triazoles; Tryptamines | 2012 |
Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Caffeine; Cells, Cultured; Central Nervous System Diseases; Cerebellum; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Wistar; Receptor, Adenosine A2A; Theophylline; Triazines; Triazoles | 2003 |
Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Avoidance Learning; Brain; Caffeine; Cognition Disorders; Disease Models, Animal; Drug Synergism; Male; Maze Learning; Mice; Neuroprotective Agents; Peptide Fragments; Phosphodiesterase Inhibitors; Pyrimidines; Receptor, Adenosine A2A; Treatment Outcome; Triazoles | 2007 |
Ability of carbazole salts, inhibitors of Alzheimer beta-amyloid fibril formation, to cross cellular membranes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Carbazoles; Cell Membrane; Cell Membrane Permeability; Cell Nucleus; Circular Dichroism; Cyclic P-Oxides; DNA; Glutathione; Humans; K562 Cells; Membrane Potentials; Multidrug Resistance-Associated Proteins; NAD; Nicotinic Acids; Oxidation-Reduction; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Time Factors; Triazoles | 2007 |
Cognitive declines therapy by iron burden reduction.
Topics: Alzheimer Disease; Benzoates; Deferasirox; Ferritins; Humans; Iron; Iron Chelating Agents; Middle Aged; Triazoles | 2007 |
Quick assembly of 1,4-diphenyltriazoles as probes targeting beta-amyloid aggregates in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Probes; Triazoles | 2007 |
Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease.
Topics: Adenylyl Cyclases; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cell Membrane; Colforsin; Cyclic AMP; Female; Frontal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Protein Binding; Receptors, Purinergic P1; Triazines; Triazoles; Tritium; Up-Regulation; Xanthines | 2008 |
Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Ligands; Radioligand Assay; Rats; Receptors, Muscarinic; Substrate Specificity; Tetrazoles; Triazoles | 1992 |