Compounds > adamantyl isothiocyanate
Page last updated: 2024-11-07

adamantyl isothiocyanate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

adamantyl isothiocyanate: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID107279
CHEMBL ID5078334
SCHEMBL ID457124
MeSH IDM0572766

Synonyms (39)

Synonym
HMS1786I06
EN300-17080
nsc-529585
nsc529585
4411-26-1
1-adamantyl isothiocyanate, 99%
AKOS000212453
inchi=1/c11h15ns/c13-7-12-11-4-8-1-9(5-11)3-10(2-8)6-11/h8-10h,1-6h2
ypkfluarljrpqm-uhfffaoysa-
isothiocyanic acid 1-adamantyl ester
I0485
1-adamantyl isothiocyanate
1-isothiocyanatotricyclo[3.3.1.1~3,7~]decane
STK802177
1-isothiocyanatoadamantane
A826491
adamantyl isothiocyanate
1-isothiocyanatotricyclo[3.3.1.13,7]decane
v33b5grd78 ,
einecs 224-564-4
nsc 529585
unii-v33b5grd78
tricyclo(3.3.1.1(3,7))decane, 1-isothiocyanato-
tricyclo(3.3.1.1'3,7)dec-1-yl isocyanate
ai3-61593
BP-11068
FT-0635278
BBL033523
SCHEMBL457124
1-isothiocyanato-adamantane
tricyclo[3.3.1.1(3,7)-]decane, 1-isothiocyanato-
F8889-2499
tricyclo[3.3.1.13,7]decane, 1-isothiocyanato-
DTXSID70196040
mfcd00074736
VS-12123
D91167
Z56872140
CHEMBL5078334
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1816763Induction of apoptosis in human MDA-MB-231 cells expressing p53 R280K mutant assessed increase in number of Annexin-V stained cells at 6 to 12 uM incubated for 24 hrs by AnnexinV-FITC and PI staining based flow cytometry2021Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships.
AID1816773Downregulation of p53 R273H mutant expression in human MDA-MB-468 cells at 6 to 12 uM measured after 24 hrs by immunoblot analysis2021Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships.
AID1816774Downregulation of p53 expression in human MCF7 cells at 6 to 12 uM measured after 24 hrs by immunoblot analysis2021Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships.
AID1816754Antiproliferative activity against human MDA-MB-231 cells expressing p53 R280K mutant assessed as inhibition of cell growth at 10 to 50 uM incubated for 24 to 72 hrs by WST-1 assay2021Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships.
AID1816793Octanol-water partition coefficient, logP of the compound by HPLC-MS analysis2021Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships.
AID1816764Induction of apoptosis in human MCF-7 cells expressing wild type p53 assessed increase in number of Annexin-V stained cells at 6 to 12 uM incubated for 24 hrs by AnnexinV-FITC and PI staining based flow cytometry2021Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships.
AID1816765Induction of apoptosis in human MDA-MB-468 cells expressing p53 R273H mutant assessed increase in number of Annexin-V stained cells at 6 to 12 uM incubated for 24 hrs by AnnexinV-FITC and PI staining based flow cytometry2021Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships.
AID1816772Downregulation of p53 R208K mutant expression in human MDA-MB-231 cells at 6 to 12 uM measured after 24 hrs by immunoblot analysis2021Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.20 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adamantane
Adamantane: A tricyclo bridged hydrocarbon.		2.8230adamantanes;
polycyclic alkane
1,2,4-triazole
1,2,4-triazole: RN given refers to 1H-1,2,4-triazole		2.11101,2,4-triazole
hydrazine
diamine : Any polyamine that contains two amino groups.		2.1110azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.0710acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
phenethyl isothiocyanate
phenethyl isothiocyanate: a dietary liver aldehyde dehydrogenase inhibitor; promotes urinary bladder carcinoma. phenethyl isothiocyanate : An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties.		2.3110isothiocyanateantineoplastic agent;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
metabolite
isothiocyanic acid
[no description available]		2.0710hydracid;
one-carbon compound
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.11101,2,3-triazole
carbohydrazide
carbohydrazide: structure. carbohydrazide : A hydrazide consisting of hydrazine carrying one or more carboacyl groups.. carbonyl dihydrazine : A carbohydrazide obtained by formal condensation between hydrazinecarboxylic acid and hydrazine.		2.1110carbohydrazide;
one-carbon compound
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Alloxan Diabetes
[description not available]		02.1110
Cancer of Ovary
[description not available]		02.0710
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.0710