An antagonist that binds to and deactivates orexin receptors.
ChEBI ID: 83296
| Member | Definition | Class |
|---|---|---|
| suvorexant | An aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia. | suvorexant |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 125 (61.88) | 24.3611 |
| 2020's | 77 (38.12) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 47 (21.96%) | 5.53% |
| Reviews | 44 (20.56%) | 6.00% |
| Case Studies | 14 (6.54%) | 4.05% |
| Observational | 5 (2.34%) | 0.25% |
| Other | 104 (48.60%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Orexin receptor type 1 | Homo sapiens (human) | IC50 | 0.0873 | 4 | 4 |
| Orexin receptor type 1 | Homo sapiens (human) | Ki | 0.0010 | 6 | 6 |
| Orexin receptor type 1 | Mus musculus (house mouse) | Ki | 0.0017 | 1 | 1 |
| Orexin receptor type 2 | Homo sapiens (human) | IC50 | 0.0613 | 5 | 5 |
| Orexin receptor type 2 | Homo sapiens (human) | Ki | 0.0027 | 5 | 5 |
| Orexin receptor type 2 | Mus musculus (house mouse) | Ki | 0.0087 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0004 | 1 | 1 |