Compounds > 14-deoxyandrographolide
Page last updated: 2024-11-12

14-deoxyandrographolide

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Description

14-deoxyandrographolide: from Andrographis paniculata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AndrographisgenusA plant genus of the family ACANTHACEAE. Members contain andrographolide and other DITERPENES and androechin, a CHALCONE.[MeSH]AcanthaceaeA plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.[MeSH]

Cross-References

ID SourceID
PubMed CID11624161
CHEMBL ID415768
MeSH IDM0295878

Synonyms (23)

Synonym
CHEMBL415768
14-deoxyandrographolide
4-[2-[(1r,4as,5r,6r,8as)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-2h-furan-5-one
4176-97-0
AC-34626
2(5h)-furanone,3-[2-[(1r,4as,5r,6r,8as)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-
3-(2-((1r,4as,5r,6r,8as)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl)furan-2(5h)-one
AKOS027324400
np-011179
2(5h)-furanone, 3-(2-((1r,4as,5r,6r,8as)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl)-
ad-04130-4
3-(2-((1r,4as,5r,6r,8as)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl)-2(5h)-furanone
WLN91FAQ6Z ,
ent-3beta-hydroxy-8(17),13(14)-labdadiene-16,15-olide 14-deoxyandrographolide
DTXSID80904638
F21512
unii-wln91faq6z
CS-0032748
HY-N4323
MS-25054
3-[2-[(1r,4abeta)-2-methylene-5alpha-(hydroxymethyl)-5,8aalpha-dimethyl-6alpha-hydroxydecalin-1alpha-yl]ethyl]-2,5-dihydrofuran-2-one
3-{2-[(1r,4as,5r,6r,8as)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethy l-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5h)-furanone
A913391
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (44)

Assay IDTitleYearJournalArticle
AID249077Concentration causing 50% inhibition of cancer cell growth against human prostate DU145 cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID1408137Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of TGFbeta1-induced increase in FN mRNA level at 500 nM preincubated for 1 hr followed by TGFbeta-1 addition measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID776229Antioxidant activity assessed as decrease in superoxide anions level by measuring formation of formazone at 200 ug/ml after 30 mins by spectrophotometric analysis relative to control2013European journal of medicinal chemistry, Nov, Volume: 69Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity.
AID1204064Cytotoxicity against human NTUB1 cells after 48 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
Synthesis of new ent-labdane diterpene derivatives from andrographolide and evaluation on cytotoxic activities.
AID1204903Cytotoxicity against human Jurkat T cells assessed as apoptosis after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID776228Antioxidant activity assessed as decrease in hydroxyl radicals level by measuring formation of malondialdehyde at 200 ug/ml after 90 mins by spectrophotometric analysis relative to control2013European journal of medicinal chemistry, Nov, Volume: 69Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity.
AID1544507Cytotoxicity in mouse BV2 cells assessed as reduction in cell viability2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID776252Antidyslipidemic activity in Charles foster rat assessed as decrease in triton WR-1339-induced total cholesterol level in plasma at 100 mg/kg, po after 18 hrs relative to triton-treated rat2013European journal of medicinal chemistry, Nov, Volume: 69Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity.
AID1544494Lipophilicity, log P of the compound2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID249072Concentration causing 50% inhibition of cancer cell growth against human CNS U251 cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID1204067Cytotoxicity against human NP14 cells after 48 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
Synthesis of new ent-labdane diterpene derivatives from andrographolide and evaluation on cytotoxic activities.
AID1408136Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of TGFbeta1-induced increase in alpha-SMA mRNA level at 500 nM preincubated for 1 hr followed by TGFbeta-1 addition measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID380100Antimicrobial activity against Bacillus subtilis at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID645483Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 100 uM after 24 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages.
AID1204909Inhibition of TNF-alpha-stimulated NF-kappaB p50 (unknown origin) expressed in HEK293 cells preincubated for 4 hrs followed by TNF-alpha challenge measured after 24 hrs by secreted alkaline phosphatase reporter assay2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID1544503Neuroprotective activity against 6-OHDA -induced toxicity in rat PC12 cells assessed as increase in cell viability at 20 uM pretreated for 24 hrs followed by 6-OHDA challenge and measured after 24 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID1408141Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of COL1A1 mRNA level at 500 nM measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID1204906Binding affinity to 6His-tagged recombinant human NF-kappaB p50 N-terminal domain expressed in Escherichia coli BL21 (DE3) up to 10:1 compound to protein molar ratio after 2 hrs by mass spectrometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID249073Concentration causing 50% inhibition of cancer cell growth against human lung H522 cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID380103Antimicrobial activity against Micrococcus luteus at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID380105Antimicrobial activity against Candida sake at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1544501Neuroprotective activity against H2O2-induced toxicity in rat PC12 cells assessed as increase in cell viability at 20 uM pretreated for 24 hrs followed by H2O2 challenge and measured after 24 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID380102Antimicrobial activity against Escherichia coli at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID249076Concentration causing 50% inhibition of cancer cell growth against human ovarian SKOV3 cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID1408132Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID1408138Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of TGFbeta1-induced increase in COL1A1 mRNA level at 500 nM preincubated for 1 hr followed by TGFbeta-1 addition measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID249083Concentration causing 50% inhibition of cancer cell growth against human breast MCF-7/ADR cell line; nd = not done2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID776227Antioxidant activity assessed as reduction of microsomal lipid per-oxidation level by measuring formation of malondialdehyde at 200 ug/ml after 90 mins by spectrophotometric analysis relative to control2013European journal of medicinal chemistry, Nov, Volume: 69Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity.
AID1204066Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
Synthesis of new ent-labdane diterpene derivatives from andrographolide and evaluation on cytotoxic activities.
AID249080Concentration causing 50% inhibition of cancer cell growth against human renal A498 cell line; nd = not done2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID380101Antimicrobial activity against Staphylococcus aureus at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID645482Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages.
AID776248Antidyslipidemic activity in Charles foster rat assessed as increase in triton WR-1339-reduced post heparin lipolytic activity level in plasma at 100 mg/kg, po after 18 hrs by spectrophotometric analysis relative to triton-treated rat2013European journal of medicinal chemistry, Nov, Volume: 69Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity.
AID1204065Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2015Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
Synthesis of new ent-labdane diterpene derivatives from andrographolide and evaluation on cytotoxic activities.
AID1544504Induction of neurite outgrowth in NGF-induced rat PC12 cells assessed as neurite bearing cells at 20 uM cotreated with 20 ng/ml NGF incubated for 48 hrs by light microscopy2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID776250Antidyslipidemic activity in Charles foster rat assessed as decrease in triton WR-1339-induced phospholipid level in plasma at 100 mg/kg, po after 18 hrs relative to triton-treated rat2013European journal of medicinal chemistry, Nov, Volume: 69Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity.
AID380106Antimicrobial activity against Aspergillus niger at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1408139Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of alpha-SMA mRNA level at 500 nM measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID249075Concentration causing 50% inhibition of cancer cell growth against human colon SW620 cell line2004Bioorganic & medicinal chemistry letters, Sep-20, Volume: 14, Issue:18
Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents.
AID380104Antimicrobial activity against Candida albicans at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1408140Antifibrotic activity against mouse NIH/3T3 cells assessed as inhibition of FN mRNA level at 500 nM measured after 24 hrs by qRT-PCR method2018European journal of medicinal chemistry, Sep-05, Volume: 157Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
AID1544493Antiinflammatory activity in mouse BV2 cells assessed as reduction in LPS-induced NO production at 20 uM incubated for 24 hrs by Griess method2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID383495Antiproliferative activity against human HL60 cells by trypan blue assay2008Journal of natural products, May, Volume: 71, Issue:5
ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata.
AID776249Antidyslipidemic activity in Charles foster rat assessed as decrease in triton WR-1339-induced triglyceride level in plasma at 100 mg/kg, po after 18 hrs relative to triton-treated rat2013European journal of medicinal chemistry, Nov, Volume: 69Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (6.67)18.2507
2000's8 (26.67)29.6817
2010's17 (56.67)24.3611
2020's3 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.74 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index5.13 (4.65)
Search Engine Demand Index27.14 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other30 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
caffeine
[no description available]		1.9910purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
fenofibrate
Pharmavit: a polyvitamin product, comprising vitamins A, D2, B1, B2, B6, C, E, nicotinamide, & calcium pantothene; may be a promising agent for application to human populations exposed to carcinogenic and genetic hazards of ionizing radiation; RN from CHEMLINE		2.0810aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic
gemfibrozil
[no description available]		2.0810aromatic etherantilipemic drug
isoproterenol
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.		2.0110catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
phenylbutazone
Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.. phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.		2.0110pyrazolidinesantirheumatic drug;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		2.2110glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
phenylephrine
Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.. phenylephrine : A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.		1.9910phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
mannitol
[no description available]		2.0810mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		2.0810alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
vanadates
Vanadates: Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.. vanadate(3-) : A vanadium oxoanion that is a trianion with formula VO4 in which the vanadium is in the +5 oxidation state and is attached to four oxygen atoms.		2.0110trivalent inorganic anion;
vanadium oxoanion		EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.8430D-glucopyranoseepitope;
mouse metabolite
web 2086
WEB 2086: structure given in first source; PAF antagonist		2.0210organonitrogen heterocyclic compound;
organosulfur heterocyclic compound
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.02101,2,3-triazole
schizandrin b
schizandrin B: a phytogenic antineoplastic agent with anti-inflammatory activity; isolated from Schisandra plant		2.0210
1-hexadecyl-2-acetyl-glycero-3-phosphocholine
Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.. 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine : A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.		3.34202-acetyl-1-alkyl-sn-glycero-3-phosphocholineantihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent
ginkgolide a
[no description available]		2.0210diterpene lactone
schizandrin a
schizandrin A: the major lignan, 2-9%, of Schisandra plant; has hepatoprotective, antioxidant, and antineoplastic activities		2.0210
oxytocin
Oxytocin: A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.. oxytocin : A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.		2.0110heterodetic cyclic peptide;
peptide hormone		oxytocic;
vasodilator agent
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.0210
dinoprost
Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.		2.0110monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite
andrographolide
[no description available]		9.28170carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol		anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite
ap 10
[no description available]		3.3260diterpene lactonemetabolite
neoandrographolide
neoandrographolide: structure in first source; isolated from Andrographis paniculata		3.4870
andrograpanin
andrograpanin: an NSAID isolated from Andrographis paniculata; structure in first source		2.7430
14-deoxy-11,12-didehydroandrographolide
14-deoxy-11,12-didehydroandrographolide: a diterpenoid from Andrographis paniculata; structure in first source		2.4620
andrographoside
[no description available]		2.4420
minocycline
Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.		2.0710
ginkgolide b
[no description available]		2.0210
dehydroandrographolide
[no description available]		2.5420
cyclic gmp
Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.		2.05103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.		2.0810nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.4720
Hyperlipemia
[description not available]		02.0810
Hyperlipidemias
Conditions with excess LIPIDS in the blood.		02.0810
Cirrhosis
[description not available]		02.1710
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.		07.1710
Acute Confusional Senile Dementia
[description not available]		02.2110
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.2110
Anasarca
[description not available]		02.5120
Innate Inflammatory Response
[description not available]		02.2510
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.5120
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.2510
Alcoholic Liver Diseases
[description not available]		02.0810
Liver Diseases, Alcoholic
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.		02.0810
Alcoholic Fatty Liver
[description not available]		02.110
Alloxan Diabetes
[description not available]		02.1110
Delayed Hypersensitivity
[description not available]		02.0510
Anoxemia
[description not available]		02.0410
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		02.0410
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position.		01.9910