Any inhibitor of nonstructural protein 5A.
ChEBI ID: 83799
| Member | Definition | Class |
|---|---|---|
| bms-790052 | A member of the class of biphenyls that is a potent inhibitor of nonstructural protein 5A and is used (as its hydrochloride salt) for treatment of hepatitis C. | daclatasvir |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 588 (81.10) | 24.3611 |
| 2020's | 137 (18.90) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 120 (15.81%) | 5.53% |
| Reviews | 85 (11.20%) | 6.00% |
| Case Studies | 56 (7.38%) | 4.05% |
| Observational | 50 (6.59%) | 0.25% |
| Other | 448 (59.03%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Interferon beta | Homo sapiens (human) | Potency | 37.0259 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 37.0259 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 29.2000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 100.0000 | 3 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 59.5000 | 3 | 3 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 100.0000 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 7.2000 | 3 | 3 |
| Nonstructural protein 5A | IC50 | 0.0000 | 2 | 2 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 29.2000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Nonstructural protein 5A | EC50 | 0.0678 | 21 | 21 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 1A2 | Homo sapiens (human) | IC90 | 100.0000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC90 | 100.0000 | 2 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC90 | 100.0000 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC90 | 100.0000 | 2 | 2 |