Page last updated: 2024-12-06

phenylpropiolic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

phenylpropiolic acid: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

phenylpropiolic acid : An acetylenic compound that is propynoic acid in which the acetylenic hydrogen is replaced by a phenyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID69475
CHEMBL ID4059878
CHEBI ID90355
SCHEMBL ID68968
MeSH IDM0072022

Synonyms (76)

Synonym
AD-266/40164861
3-phenyl-2-propynoic acid
3-phenylpropynoic acid
phenylacetylenecarboxylic acid
phenylacetylene monocarboxylic acid
phenylpropynoic acid
nsc13669
3-phenylpropiolic acid
2-propynoic acid, 3-phenyl-
propiolic acid, 3-phenyl-
637-44-5
propiolic acid, phenyl-
nsc-13669
phenylpropiolic acid
phenylpropiolic acid, 99%
inchi=1/c9h6o2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5h,(h,10,11
P-4190
STK208480
3-phenylprop-2-ynoic acid
phenylpropargylic acid
P0610
AKOS000121851
3-phenylprop-2-ynoate;3-phenylpropiolic acid
A834500
phenyl-propiolic acid
ai3-17875
unii-4ke28xz9gx
einecs 211-285-8
nsc 13669
4ke28xz9gx ,
3-phenyl-prop-2-ynoic acid
phenyl propiolic acid
phenylpropiolate
FT-0632705
SCHEMBL68968
3-phenylprop-2-ynic acid
3-phenyl-propiolic acid
3-phenyl propiolic acid
phenyl-propynoic acid
DTXSID7060918
3-phenyl-2-propynoic acid #
.beta.-phenylpropargylic acid
3-phenyl-propynoic acid
3-phenylpropargylic acid
phenylacetylenemonocarboxylic acid
mfcd00004361
CS-W007319
CHEBI:90355
beta-phenylpropargylic acid
phenyl-(8ci)propiolic acid
phenyl-propiolate
3-phenylpropiolate
3-phenyl-propiolate
phenylpropioplic acid
b-phenylpropargylic acid
phenylpropynoate
b-phenylpropargylate
phenylpropioplate
3-phenylpropynoate
phenylacetylenecarboxylate
phenylacetylene monocarboxylate
beta-phenylpropargylate
3-phenyl-2-propynoate
SY023402
DS-18242
phenyl-(8ci)propiolate
Q7181437
AMY202100111
EN300-28604
CHEMBL4059878
jq8 ,
phenylpropiolsa currencyure
HY-W007319
4-phenylpropynoic acid
phenyl-2-propynoic acid
Z271128592
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
alpha,beta-unsaturated monocarboxylic acidA monocarboxylic acid in which the carbon of the carboxy group is directly attached to a C=C or C#C bond.
acetylenic compoundAny organic molecule containing a C#C bond.
benzenesAny benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1432759Inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production by measuring initial state enzyme-inhibitor complex using urea as substrate measured for 120 mins by phenol-hypochlorite method2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling.
AID1432754Time-dependent Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production using urea as substrate by phenol-hypochlorite method2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling.
AID1432751Inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production using urea as substrate measured for 120 mins by phenol-hypochlorite method2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling.
AID1432756Reversible inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production by measuring recovery of enzyme activity at 10 times IC50 preincubated for 60 mins followed by 100-fold dilution in to PBS containing urea as subst2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling.
AID1432760Inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production by measuring steady state enzyme-inhibitor complex using urea as substrate measured for 120 mins by phenol-hypochlorite method2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling.
AID1432755Competitive inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production preincubated with enzyme followed by addition of varying levels of urea as substrate measured for 120 mins by Lineweaver-Burk plot analysis2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (4.00)18.2507
2000's8 (32.00)29.6817
2010's15 (60.00)24.3611
2020's1 (4.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.59 (24.57)
Research Supply Index3.30 (2.92)
Research Growth Index5.06 (4.65)
Search Engine Demand Index48.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]