triazoles has been researched along with gsk525762a in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 28 (93.33) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Denu, JM; Oliver, SS | 1 |
| Anderson, KC; Bergsagel, PL; Bradner, JE; Chesi, M; Delmore, JE; Ghobrial, IM; Gilpatrick, T; Hahn, WC; Heffernan, TP; Issa, GC; Jacobs, HM; Kastritis, E; Kung, AL; Lemieux, ME; McKeown, MR; Mitsiades, CS; Paranal, RM; Qi, J; Rahl, PB; Richardson, PG; Schinzel, AC; Shi, J; Vakoc, CR; Young, RA | 1 |
| Maxmen, A | 1 |
| Aull, K; Boehm, D; Bradner, JE; Calvanese, V; Dar, RD; Li, PC; Martins, L; Ott, M; Planelles, V; Schroeder, S; Siliciano, RF; Verdin, E; Weinberger, L; Xing, S; Zhou, MM | 1 |
| Bradner, JE; Cerulli, R; Frank, DA; Liu, S; Nelson, EA; Qi, J; Stone, RM; Toniolo, PA; Wadleigh, M; Walker, SR; Xiang, M | 1 |
| Günther, S; Lucas, X | 1 |
| Alluri, PG; Asangani, IA; Chinnaiyan, AM | 1 |
| Figg, WD; Lochrin, SE; Price, DK | 1 |
| Baud, MG; Ciulli, A; Lin-Shiao, E; Tallant, C; Zengerle, M | 1 |
| Abdel-Wahab, O; Carpenter, C; Dawson, MA; Dawson, SJ; Fong, CY; Ftouni, S; Gilan, O; Giotopoulos, G; Gregory, R; Huntly, BJ; Jeffrey, P; Johnstone, RW; Kouzarides, T; Lam, EY; Lane, SW; Lee, SC; Lugo, D; Morison, J; Papenfuss, AT; Prinjha, RK; Ramsay, RG; Rubin, AF; Sinha, D; Stanley, K; Tyler, D; Yeh, P | 1 |
| Ferri, E; McKenna, CE; Petosa, C | 1 |
| Baldan, F; Conzatti, K; Damante, G; Di Cristofano, A; Di Loreto, C; Durante, C; Filetti, S; Lavarone, E; Mio, C; Orlacchio, A; Puppin, C; Russo, D; Toffoletto, B | 1 |
| Honkakoski, P; Hytti, M; Kaarniranta, K; Kauppinen, A; Korhonen, E; Lahtela-Kakkonen, M; Määttä, E; Piippo, N; Suuronen, T; Tokarz, P | 1 |
| Blee, AM; Huang, H; Liu, S; Wang, L | 1 |
| Amemiya, S; Hashimoto, Y; Noguchi-Yachide, T; Sakai, T; Yamaguchi, T | 1 |
| Gelato, KA; Haendler, B; Klingbeil, O; Lejeune, P; Lesche, R | 1 |
| Leal, AS; Liby, KT; Pioli, PA; Royce, DB; Sporn, MB; Williams, CR | 1 |
| Ando, A; Baba, Y; Ebara, S; Hara, T; Kitazawa, S; Satomi, Y; Soga, T | 1 |
| Champleboux, M; Chauvel, M; Cornet, M; Courçon, M; d'Enfert, C; Ferri, E; Garnaud, C; Govin, J; Harbut, M; Hull, M; Kashemirov, BA; Maubon, D; McKenna, CE; Mietton, F; Petosa, C; Spittler, D; Zala, N; Zhou, Y | 1 |
| Beltran, H; Demichelis, F; Rickman, DS; Rubin, MA | 1 |
| Dang, CV; Fan, L; Fan, Y; Hu, X; Hu, Z; Huang, Q; Li, C; Montone, K; Pi, J; Shan, W; Tang, Z; Tanyi, JL; Wang, Y; Yang, L; Yuan, J; Zhang, L; Zhang, Y | 1 |
| Barbieri, CE; Beca, F; Beck, AH; Blattner, M; Bradner, JE; Buckley, DL; Buser, L; Chen, T; Chen, Y; Dai, X; Gan, W; Garraway, LA; Guo, J; Huang, J; Huang, L; Inuzuka, H; Li, X; Liu, P; Liu, S; Muthuswamy, SK; Qi, J; Rubin, MA; Shimizu, K; Vasudevan, D; Wang, L; Wang, S; Wei, W; Wild, PJ; Wong, KK; Zhang, J; Zhang, W; Zhong, Q | 1 |
| Gehringer, M; Laufer, SA | 1 |
| Allegri, L; Baldan, F; Conzatti, K; Damante, G; Filetti, S; Mio, C; Rosignolo, F; Russo, D; Sponziello, M | 1 |
| Chen, X; Fan, Y; Mao, R; Ming, Y; Shen, J; Wang, C; Wang, S; Wang, Y; Wu, Y; Xu, Y; Yang, R | 1 |
| Barbina, M; Bolis, M; Caponnetto, F; Damante, G; Di Loreto, C; Garattini, E; Gerratana, L; Mio, C; Puglisi, F; Zanello, A | 1 |
| Allegri, L; Baldan, F; Catia, M; Damante, G; Lazarevic, M; Milasin, J; Milosevic, M | 1 |
| Allegri, L; Baldan, F; Bulotta, S; Celano, M; Damante, G; Falcone, R; Lepore, SM; Maggisano, V; Maranghi, M; Mio, C; Pecce, V; Rosignolo, F; Russo, D; Sponziello, M; Verrienti, A | 1 |
| Potluri, A; Radhakrishnan, SK; Vangala, JR | 1 |
| Järvenpää, J; Küblbeck, J; Lahtela-Kakkonen, M; Rahnasto-Rilla, M | 1 |
2 review(s) available for triazoles and gsk525762a
| Article | Year |
|---|---|
BET bromodomain inhibitors--a novel epigenetic approach in castration-resistant prostate cancer.
Topics: Animals; Antineoplastic Agents; Azepines; Benzodiazepines; Cell Cycle Proteins; Epigenesis, Genetic; Humans; Male; Nuclear Proteins; Prostatic Neoplasms, Castration-Resistant; Transcription Factors; Triazoles | 2014 |
Bromodomains: Structure, function and pharmacology of inhibition.
Topics: Acetylation; Antineoplastic Agents; Autoimmune Diseases; Azepines; Benzodiazepines; Cardiotonic Agents; Cardiovascular Diseases; Chromatin; Chromatin Assembly and Disassembly; Drug Discovery; Epigenesis, Genetic; Histones; Humans; Models, Molecular; Neoplasms; Transcription Factors; Transcription, Genetic; Triazoles | 2016 |
28 other study(ies) available for triazoles and gsk525762a
| Article | Year |
|---|---|
Disrupting the reader of histone language.
Topics: Azepines; Benzodiazepines; Cell Cycle Proteins; Chromatin; Epigenesis, Genetic; Heterocyclic Compounds, 4 or More Rings; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Nuclear Proteins; Protein Serine-Threonine Kinases; Stereoisomerism; Transcription Factors; Triazoles | 2011 |
BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
Topics: Animals; Antineoplastic Agents; Azepines; Benzodiazepines; Cell Line, Tumor; Disease Models, Animal; Drug Discovery; Humans; Mice; Multiple Myeloma; Nuclear Proteins; Protein Structure, Tertiary; Proto-Oncogene Proteins c-myc; Transcriptional Activation; Triazoles | 2011 |
Cancer research: Open ambition.
Topics: Adult; Animals; Azepines; Benzodiazepines; Cell Cycle Proteins; Child; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia; Male; Mice; Mutation; Neoplasm Proteins; Neoplasms; Nuclear Proteins; Oncogene Proteins; Oncogene Proteins, Fusion; Proto-Oncogene Proteins c-myc; Transcription Factors; Triazoles; Vorinostat; Young Adult | 2012 |
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.
Topics: Azepines; Benzodiazepines; CD4-Positive T-Lymphocytes; Cell Cycle Proteins; Cells, Cultured; HEK293 Cells; Heterocyclic Compounds, 4 or More Rings; HIV Infections; HIV-1; Humans; Jurkat Cells; Nuclear Proteins; Positive Transcriptional Elongation Factor B; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; RNA Interference; RNA, Small Interfering; tat Gene Products, Human Immunodeficiency Virus; Transcription Factors; Transcription, Genetic; Triazoles; Virus Latency | 2013 |
Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2.
Topics: Azepines; Benzodiazepines; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hematologic Neoplasms; Humans; Leukemia; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; RNA, Small Interfering; STAT5 Transcription Factor; Transcription Factors; Triazoles | 2014 |
Targeting the BET family for the treatment of leukemia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Azepines; Benzodiazepines; Cell Cycle Proteins; Cell Proliferation; Gene Expression; Humans; Leukemia; Nuclear Proteins; Protein Serine-Threonine Kinases; Quinazolines; Quinazolinones; RNA-Binding Proteins; Transcription Factors; Triazoles | 2014 |
BETs abet Tam-R in ER-positive breast cancer.
Topics: Acetylation; Azepines; Benzodiazepines; Breast Neoplasms; Cell Cycle Proteins; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Histone-Lysine N-Methyltransferase; Histones; Humans; Nuclear Proteins; Protein Serine-Threonine Kinases; Receptors, Estrogen; Repressor Proteins; RNA-Binding Proteins; Tamoxifen; Transcription Factors; Triazoles | 2014 |
New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.
Topics: Benzodiazepines; Cell Cycle Proteins; Drug Design; Humans; Molecular Docking Simulation; Nuclear Proteins; Protein Serine-Threonine Kinases; Transcription Factors; Triazoles | 2016 |
BET inhibitor resistance emerges from leukaemia stem cells.
Topics: Animals; Azepines; Benzodiazepines; beta Catenin; Cell Cycle Proteins; Cell Line, Tumor; Cells, Cultured; Chromatin; Clone Cells; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genes, myc; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Mice; Molecular Targeted Therapy; Neoplastic Stem Cells; Nuclear Proteins; Transcription Factors; Transcription, Genetic; Triazoles; Wnt Signaling Pathway | 2015 |
MCM5 as a target of BET inhibitors in thyroid cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azepines; Benzodiazepines; Carcinoma; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Mice, Knockout; Neoplasm Proteins; Nuclear Proteins; Thyroid Gland; Thyroid Neoplasms; Triazoles | 2016 |
Inhibition of BET bromodomains alleviates inflammation in human RPE cells.
Topics: Anti-Inflammatory Agents; Azabicyclo Compounds; Azepines; Benzodiazepines; Carbazoles; Cell Line; Cell Survival; Epithelial Cells; Etoposide; Gene Expression Regulation; Humans; Inflammation; Interleukin-6; Interleukin-8; Models, Biological; NF-kappa B; Protein Domains; Pyridines; Retinal Pigment Epithelium; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Topoisomerase II Inhibitors; Transcription Factors; Triazoles; Tumor Suppressor Protein p53 | 2016 |
BET bromodomain-mediated interaction between ERG and BRD4 promotes prostate cancer cell invasion.
Topics: Azepines; Base Sequence; Benzodiazepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; HEK293 Cells; Humans; Male; Neoplasm Invasiveness; Nuclear Proteins; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Proteins; Transcription Factors; Transcriptional Regulator ERG; Triazoles | 2016 |
Structure-Activity Relationship Study of N(6)-Benzoyladenine-Type BRD4 Inhibitors and Their Effects on Cell Differentiation and TNF-α Production.
Topics: Antineoplastic Agents; Azepines; Benzodiazepines; Cell Cycle Proteins; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Molecular Structure; Nuclear Proteins; Structure-Activity Relationship; Transcription Factors; Triazoles; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2016 |
Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents.
Topics: A549 Cells; Acetanilides; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Benzodiazepines; Carcinoma, Non-Small-Cell Lung; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Cycle; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Lung Neoplasms; Mice, SCID; Mutation; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Triazoles; X-Linked Inhibitor of Apoptosis Protein; Xenograft Model Antitumor Assays | 2016 |
Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Azepines; Benzodiazepines; Cell Line, Tumor; Cell Proliferation; Ceruletide; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Humans; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Pancreatic Neoplasms; Pancreatitis; Phosphorylation; Proto-Oncogene Proteins c-myc; RAW 264.7 Cells; Signal Transduction; Triazoles | 2017 |
Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors.
Topics: Antineoplastic Agents; Azepines; Benzodiazepines; Citric Acid Cycle; CRISPR-Cas Systems; Dehydroepiandrosterone; Fumarates; Gene Knockout Techniques; Glucosephosphate Dehydrogenase; Glycolysis; HCT116 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Metabolomics; Mitochondria; Mutation; Neoplasms; Oxygen Consumption; Phenformin; Phosphoglycerate Dehydrogenase; Proto-Oncogene Proteins c-myc; RNA Interference; RNA, Small Interfering; Succinate Dehydrogenase; Succinic Acid; Triazoles | 2017 |
Selective BET bromodomain inhibition as an antifungal therapeutic strategy.
Topics: Amino Acid Sequence; Animals; Antifungal Agents; Azabicyclo Compounds; Azepines; Benzodiazepines; Binding Sites; Candida albicans; Candidiasis; Crystallography, X-Ray; Fungal Proteins; Gene Expression; Humans; Mice; Models, Molecular; Molecular Targeted Therapy; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Pyridines; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Transcription Factors; Triazoles | 2017 |
Biology and evolution of poorly differentiated neuroendocrine tumors.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Azepines; Benzodiazepines; Carcinogenesis; Carcinoma, Neuroendocrine; Carcinoma, Small Cell; Cell Differentiation; Cell Lineage; Cell Plasticity; Colonic Neoplasms; Disease Progression; Epigenesis, Genetic; Esophageal Neoplasms; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Molecular Targeted Therapy; Neoplasms, Glandular and Epithelial; Neuroendocrine Tumors; Ovarian Neoplasms; Prostatic Neoplasms; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-myc; Pyrimidines; Retinoblastoma Binding Proteins; Triazoles; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 2017 |
Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition.
Topics: Acetanilides; Animals; Antineoplastic Agents; Azepines; Benzodiazepines; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Drug Synergism; Female; Heterocyclic Compounds, 3-Ring; Homologous Recombination; Humans; Ovarian Neoplasms; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Triazoles | 2017 |
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
Topics: Apoptosis; Azepines; Benzodiazepines; Cell Cycle Proteins; Cell Proliferation; Cullin Proteins; Drug Resistance, Neoplasm; HEK293 Cells; HeLa Cells; Humans; Immunoblotting; Immunoprecipitation; Male; Molecular Targeted Therapy; Nuclear Proteins; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Repressor Proteins; RNA-Binding Proteins; Thalidomide; Transcription Factors; Triazoles; Ubiquitination | 2017 |
Click Chemistry: Novel Applications in Cell Biology and Drug Discovery.
Topics: Azepines; Benzodiazepines; Cell Biology; Click Chemistry; Drug Discovery; Humans; Molecular Structure; Proteins; Triazoles | 2017 |
BET bromodomain inhibitor JQ1 modulates microRNA expression in thyroid cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Azepines; Benzodiazepines; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Humans; MicroRNAs; Phosphorylation; STAT3 Transcription Factor; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Triazoles | 2018 |
A super-enhancer maintains homeostatic expression of Regnase-1.
Topics: Animals; Azepines; Benzodiazepines; Cell Line; Down-Regulation; Enhancer Elements, Genetic; HEK293 Cells; Homeostasis; Humans; Introns; Mice; NIH 3T3 Cells; Ribonucleases; Sequence Deletion; Transcription Factors; Triazoles | 2018 |
BET proteins regulate homologous recombination-mediated DNA repair: BRCAness and implications for cancer therapy.
Topics: Antineoplastic Agents; Azepines; Benzodiazepines; BRCA1 Protein; Cell Cycle Proteins; Cell Line, Tumor; Cisplatin; DNA Damage; Female; Gene Expression Regulation, Neoplastic; Humans; Nuclear Proteins; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Rad51 Recombinase; Recombinational DNA Repair; RNA Interference; Transcription Factors; Triazoles; Triple Negative Breast Neoplasms | 2019 |
Biological and molecular effects of bromodomain and extra-terminal (BET) inhibitors JQ1, IBET-151, and IBET-762 in OSCC cells.
Topics: Antineoplastic Agents; Azepines; Benzodiazepines; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Epithelial-Mesenchymal Transition; Humans; Mouth Neoplasms; Neoplastic Stem Cells; Triazoles | 2019 |
Human telomerase reverse transcriptase in papillary thyroid cancer: gene expression, effects of silencing and regulation by BET inhibitors in thyroid cancer cells.
Topics: Adult; Aged; Azepines; Benzodiazepines; Cell Line, Tumor; Female; Humans; Male; Middle Aged; Proteins; Telomerase; Thyroid Cancer, Papillary; Thyroid Neoplasms; Triazoles; Young Adult | 2019 |
BET Inhibitors Synergize with Carfilzomib to Induce Cell Death in Cancer Cells via Impairing Nrf1 Transcriptional Activity and Exacerbating the Unfolded Protein Response.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azepines; Benzodiazepines; Cell Death; Cell Line, Tumor; Drug Synergism; Heterocyclic Compounds, 4 or More Rings; Humans; NF-E2-Related Factor 1; Oligopeptides; Proteasome Inhibitors; Triazoles; Unfolded Protein Response | 2020 |
Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines.
Topics: Azepines; Benzazepines; Benzodiazepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Humans; Isoxazoles; Proteins; Sirtuins; Transcription Factors; Triazoles | 2022 |