triazoles has been researched along with cem 101 in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 72 (91.14) | 24.3611 |
| 2020's | 7 (8.86) | 2.80 |
| Authors | Studies |
|---|---|
| Appelbaum, PC; Beachel, L; Clark, C; Dewasse, B; Kosowska-Shick, KM; McGhee, P; Nagai, K | 1 |
| Castanheira, M; Farrell, DJ; Jones, RN; Moet, GJ; Putnam, SD | 1 |
| Hammerschlag, MR; Kohlhoff, SA; Parker, C; Roblin, PM | 1 |
| Jones, RN; Rhomberg, PR; Ross, JE | 1 |
| Castanheira, M; Jones, RN; Woosley, LN | 1 |
| Biedenbach, DJ; Castanheira, M; Farrell, DJ; Jones, RN; Rhomberg, PR; Sader, HS | 1 |
| Biedenbach, DJ; Castanheira, M; Jones, RN | 1 |
| Castanheira, M; Farrell, DJ; Jones, RN; Sader, HS | 1 |
| Cate, JH; Dunkle, J; Fernandes, P; Klepacki, D; Llano-Sotelo, B; Mankin, AS; Zhang, W | 1 |
| Biedenbach, DJ; Castanheira, M; Farrell, DJ; Putnam, SD; Sader, HS | 1 |
| Clark, K; Degenhardt, TP; Fernandes, P; Gutierrez, MJ; Schranz, J; Scott, D; Still, JG | 1 |
| Bathurst, I; Craft, JC; Ekland, E; Fernandes, P; Fidock, DA; Lotharius, J; Wittlin, S | 1 |
| Fernandes, P; Golparian, D; Jensen, JS; Ohnishi, M; Unemo, M | 1 |
| Clark, K; Fernandes, P; Gotfried, MH; Rodvold, KA; Still, JG | 1 |
| Champney, WS; Frazier, AD; Rodgers, W | 1 |
| Barnes, PJ; Goto, H; Higaki, M; Ito, K; Kobayashi, Y; Mikura, S; Rossios, C; Takagi, D; Wada, H | 1 |
| Clark, K; Craft, JC; Das, A; Fernandes, P; Jamieson, BD; Oldach, D; Schranz, J; Scott, D | 1 |
| Barnes, PJ; Charron, C; Ito, K; Kobayashi, Y; Rossios, C; Takagi, D; Wada, H | 1 |
| Fernandes, P; Johnson, D; Keelan, JA; Kemp, MW; Newnham, JP; Payne, MS; Saito, M; Stock, SJ | 1 |
| Fernandes, P; Guyard, C; Mallegol, J; Melano, RG | 1 |
| Bonfanti, C; Caccuri, F; Caruso, A; De Francesco, MA; Fernandes, P; Piccinelli, G | 1 |
| Fernandes, P; Jensen, JS; Unemo, M | 1 |
| Carter, S; Jobe, AH; Kallapur, SG; Keelan, JA; Kemp, MW; Miura, Y; Newnham, JP; Noe, A; Payne, MS; Saito, M; Spiller, OB; Stock, SJ; Watts, R | 1 |
| Van Bambeke, F | 1 |
| Keelan, JA; Pugazhenthi, K | 1 |
| Farrell, DJ; Jones, RN; Mendes, RE | 1 |
| Muccioli, GG; Tulkens, PM; Van Bambeke, F; Vandevelde, NM | 1 |
| Ciric, S; Fernandes, P; Jamieson, BD | 1 |
| Mushtaq, A | 1 |
| Dixon, PB; Fernandes, P; Golden, M; Harbison, HS; Hook, EW; Jamieson, BD; Lowens, S | 1 |
| Furfaro, LL; Keelan, JA; Payne, MS; Spiller, OB | 1 |
| Farrell, DJ; Flamm, RK; Jones, RN; Riedel, S; Ross, JE | 1 |
| Argyle, SA; Fernandez-Brando, RJ; Gally, DL; Gillespie, T; McAteer, SP; Palermo, MS; Tahoun, A; Wang, D; Yamaguchi, N | 1 |
| Chong, Y; Lee, H; Lee, K | 1 |
| Tulkens, PM; Van Bambeke, F | 1 |
| Antonovsky, Y; Barrera, CM; Clark, K; Das, AF; Doreski, PA; Fernandes, P; Flores-Figueroa, J; Horwith, G; Jamieson, B; Karimjee, N; Keedy, K; Metev, H; Mitha, I; Molina, JM; Mykietiuk, A; Nitu, MF; Oldach, D; Rewerska, B; Rowe, BH; Scott, D; Sheets, A; Tanaseanu, CM; Van Rensburg, DJ | 1 |
| Andrade, RB; Buttaro, B; Childers, WE; Colussi, DJ; Cooperman, BS; Daher, SS; Glassford, I; Jacobson, MA; MacKerell, AD; Nicholson, AW; Redhu, SK; Small, MC; Teijaro, CN; Weil, A | 1 |
| Al-Uzri, A; Benjamin, DK; Bhattacharya-Mithal, L; Bradley, J; Cohen-Wolkowiez, M; Fernandes, P; Gonzalez, D; Hornik, CP; James, LP; Jasion, T; Keedy, K; Neu, N; Palazzi, DL; Smith, PB | 1 |
| Farrell, DJ; Flamm, RK; Jones, RN; Sader, HS | 1 |
| Holm, J; Nord, CE; Panagiotidis, G; Rashid, MU; Rosenborg, S; Söderberg Löfdal, K; Weintraub, A | 1 |
| Allu, SR; Carlsen, PN; Condakes, ML; Fukuzaki, T; Green, WD; Hog, DT; Jakubec, P; Kitamura, Y; Langlois-Mercier, A; Myers, AG; Seiple, IB; Szczypiński, FT; Wright, PM; Yabu, K; Zhang, Z; Zhou, X | 1 |
| Fernandes, P; Figueira, M; Pelton, SI | 1 |
| Das, AF; Fernandes, P; File, TM; Gonong, JRV; Jamieson, BD; Keedy, K; Oldach, D; Rewerska, B; Sheets, A; Taylor, D; Vucinic-Mihailovic, V | 1 |
| Bertrand, D; Fernandes, P; Martens, E; Pereira, D | 1 |
| Fernandes, P; Hardy, DJ; Vicino, D | 1 |
| Carratalà, J; Ramos, L; Ramos, O; Simonetti, AF; Viasus, D | 1 |
| Darpo, B; Fernandes, P; Jamieson, BD; Keedy, K; Oldach, D; Sager, PT; Zhou, M | 1 |
| Adam, H; Gin, AS; Golden, A; Gorityala, B; Hartel, E; Hoban, DJ; Karlowsky, JA; Lagacé-Wiens, PR; Lynch, JP; Schweizer, F; Walkty, AJ; Zelenitsky, S; Zhanel, GG; Zhanel, MA | 1 |
| Mason, JW | 1 |
| Owens, B | 1 |
| Rademacher, J; Welte, T | 1 |
| Aitken, SL; Brown, JE; Buege, MJ | 1 |
| Gandhi, MA; Mancuso, AM; Slish, J | 1 |
| Doll, MA; Hein, DW | 1 |
| Cohen-Wolkowiez, M; Edginton, A; Gonzalez, D; Hornik, CP; Jamieson, BD; Salerno, SN; Watt, KM | 1 |
| Evans, D; Fernandes, P; Pereira, D; Wu, S; Yalkowsky, S | 1 |
| Deol, HS; Donald, BJ; Mbadugha, UJ; Surani, S; Udeani, G | 1 |
| Fernandes, P; Kam, WR; Liu, Y; Sullivan, DA | 1 |
| Fernandes, P; Jamieson, BD; Keedy, K; MacLauchlin, C; Schneider, SE | 1 |
| Bai, B; Chen, Z; Deng, M; Deng, Q; Deng, X; Li, D; Li, G; Lin, Z; Liu, X; Wang, H; Xu, G; Yao, W; Yu, Z; Zheng, J | 1 |
| Gao, L; Hua, Z; Liu, E; Shen, L; Wang, Y | 1 |
| Adler-Shohet, FC; Al-Uzri, A; Benjamin, DK; Boakye-Agyeman, F; Bosheva, M; Bradley, JS; Cohen-Wolkowiez, M; Espinosa, C; Gonzalez, D; Hernandez, R; Hornik, CP; James, LP; Jasion, T; Marquez, L; Mendley, SR; Moffett, K; Simonsen, KA; Stoilov, S; Tsonkova, E | 1 |
| Bristow, CC; Cristillo, AD; Dillon, JA; Dong, H; Grad, YH; Kirkcaldy, RD; Klausner, JD; Lawrence, K; Morris, SR; Nicholas, RA; Oldach, D; Rice, PA; Shafer, WM; Torrone, E; Wi, TE; Zhou, P | 1 |
| Chen, F; Wang, X; Wen, J; Zhao, M | 1 |
| Andrade, RB; Buttaro, B; Daher, SS; Freundlich, JS; Jin, X; Patel, J | 1 |
| de Vries, HJC; Schim-van der Loeff, MF | 1 |
| Avery, A; Bradshaw, CS; Chen, MY; Das, AF; Donovan, B; Fairley, CK; Hardy, D; Hocking, JS; Howden, BP; McNulty, A; Nenninger, A; Oldach, D; Tabrizi, SN; Whiley, D | 1 |
| An, PH; Li, MS; Linh, HQ; Nguyen, HL; Thai, NQ | 1 |
| Lewis, DA | 1 |
| Beechinor, RJ; Cohen-Wolkowiez, M; Gonzalez, D; Hernandez, R; Hornik, CP; Jasion, T; Lang, JE | 1 |
| Craft, JC; Fernandes, P | 1 |
| Amrane, S; Raoult, D | 1 |
| Min, YH | 1 |
| Hasegawa, H; Kaku, N; Kawamoto, Y; Kosai, K; Morinaga, Y; Sakamoto, K; Uno, N; Yanagihara, K | 1 |
| Deng, Q; Wang, Y; Wang, Z; Wen, Z; Xiong, Y; Xu, G; Yu, Z; Zheng, J | 1 |
| Carreño, FO; Cohen-Wolkowiez, M; Edginton, AN; Gonzalez, D; Salerno, SN | 1 |
| Andrade, RB; Buttaro, B; Daher, SS; Jacobson, MA; Jin, X; Lee, M; Teijaro, CN; Wheeler, SE | 1 |
| Andrade, RB; Barnett, PR; Daher, SS; Freundlich, JS; Jin, X; Lee, M; Teijaro, CN | 1 |
| Al-Uzri, A; Benjamin, DK; Borja-Tabora, CFC; Bosheva, M; Bradley, JS; Cohen-Wolkowiez, M; Di John, D; Elliott, C; Ericson, JE; Friedel, D; Gonczi, F; Hornik, C; Hornik, CP; Isidro, MGD; James, LP; Kalocsai, K; Koutroulis, I; Laki, I; Lang, JE; Mendez Echevarria, A; Nad, M; Ong-Lim, ALT; Silverstein, A; Simon, G; Syed, S; Szabo, E | 1 |
11 review(s) available for triazoles and cem 101
| Article | Year |
|---|---|
Renaissance of antibiotics against difficult infections: Focus on oritavancin and new ketolides and quinolones.
Topics: Anti-Bacterial Agents; Bacterial Infections; Drug Resistance, Bacterial; Glycopeptides; Humans; Lipoglycopeptides; Macrolides; Quinolones; Triazoles | 2014 |
New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae.
Topics: Anti-Bacterial Agents; Azithromycin; Barbiturates; Ceftriaxone; Drug Resistance, Bacterial; Drug Therapy, Combination; Gonorrhea; Humans; Isoxazoles; Macrolides; Morpholines; Neisseria gonorrhoeae; Neisseriaceae Infections; Oxazolidinones; Pharyngitis; Spectinomycin; Spiro Compounds; Triazoles | 2016 |
The role of solithromycin in the management of bacterial community-acquired pneumonia.
Topics: Anti-Bacterial Agents; Clinical Trials as Topic; Community-Acquired Infections; Humans; Macrolides; Triazoles | 2016 |
The solithromycin journey-It is all in the chemistry.
Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Humans; Macrolides; Microbial Sensitivity Tests; Molecular Conformation; Respiratory Tract Infections; Triazoles | 2016 |
Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia.
Topics: Animals; Anti-Bacterial Agents; Community-Acquired Infections; Humans; Macrolides; Microbial Sensitivity Tests; Pneumonia, Bacterial; Streptococcus pneumoniae; Triazoles | 2016 |
[New antibiotics - standstill or progress].
Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Infections; Ceftaroline; Ceftazidime; Cephalosporins; Clinical Trials as Topic; Drug Approval; Drug Combinations; Drug Resistance, Multiple, Bacterial; Ephedrine; Humans; Macrolides; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Penicillanic Acid; Phenobarbital; Staphylococcal Infections; Tazobactam; Theophylline; Triazoles | 2017 |
Solithromycin: A novel ketolide antibiotic.
Topics: Animals; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Community-Acquired Infections; Drug Approval; Drug Resistance, Bacterial; Humans; Ketolides; Macrolides; Microbial Sensitivity Tests; Pneumonia, Bacterial; Triazoles; United States; United States Food and Drug Administration | 2017 |
Solithromycin (CEM-101): A New Fluoroketolide Antibiotic and Its Role in the Treatment of Gonorrhea.
Topics: Anti-Bacterial Agents; Clinical Trials as Topic; Drug Resistance, Bacterial; Gonorrhea; Humans; Macrolides; Treatment Outcome; Triazoles | 2018 |
Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy.
Topics: Anti-Bacterial Agents; Community-Acquired Infections; Drug Resistance, Bacterial; Humans; Macrolides; Microbial Sensitivity Tests; Molecular Conformation; Pneumonia, Bacterial; Streptococcus pneumoniae; Triazoles | 2017 |
Solithromycin monotherapy for treatment of community-acquired bacterial pneumonia: A meta-analysis of randomised controlled trials.
Topics: Anti-Bacterial Agents; Community-Acquired Infections; Drug Administration Schedule; Female; Humans; Macrolides; Male; Middle Aged; Multicenter Studies as Topic; Pneumonia, Bacterial; Randomized Controlled Trials as Topic; Triazoles | 2019 |
New treatment options for Neisseria gonorrhoeae in the era of emerging antimicrobial resistance.
Topics: Acenaphthenes; Anti-Bacterial Agents; Barbiturates; Drug Development; Drug Resistance, Multiple, Bacterial; Gonorrhea; Heterocyclic Compounds, 3-Ring; Humans; Isoxazoles; Macrolides; Morpholines; Neisseria gonorrhoeae; Oxazolidinones; Spiro Compounds; Triazoles | 2019 |
13 trial(s) available for triazoles and cem 101
| Article | Year |
|---|---|
Pharmacokinetics of solithromycin (CEM-101) after single or multiple oral doses and effects of food on single-dose bioavailability in healthy adult subjects.
Topics: Administration, Oral; Adult; Area Under Curve; Double-Blind Method; Fasting; Female; Humans; Macrolides; Male; Middle Aged; Triazoles; Young Adult | 2011 |
Comparison of plasma, epithelial lining fluid, and alveolar macrophage concentrations of solithromycin (CEM-101) in healthy adult subjects.
Topics: Adolescent; Adult; Bronchoalveolar Lavage; Chromatography, High Pressure Liquid; Female; Humans; Macrolides; Macrophages, Alveolar; Male; Middle Aged; Tandem Mass Spectrometry; Triazoles; Young Adult | 2012 |
Randomized, double-blind, multicenter phase 2 study comparing the efficacy and safety of oral solithromycin (CEM-101) to those of oral levofloxacin in the treatment of patients with community-acquired bacterial pneumonia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Community-Acquired Infections; Double-Blind Method; Female; Humans; Levofloxacin; Macrolides; Male; Middle Aged; Ofloxacin; Pneumonia, Bacterial; Treatment Outcome; Triazoles; Young Adult | 2013 |
A Phase 2 Trial of Oral Solithromycin 1200 mg or 1000 mg as Single-Dose Oral Therapy for Uncomplicated Gonorrhea.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Gonorrhea; Humans; Macrolides; Male; Middle Aged; Neisseria gonorrhoeae; Triazoles; Young Adult | 2015 |
Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial (SOLITAIRE-ORAL).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Community-Acquired Infections; Double-Blind Method; Europe; Female; Fluoroquinolones; Humans; Latin America; Macrolides; Male; Middle Aged; Moxifloxacin; North America; Pneumonia, Bacterial; South Africa; Triazoles; Young Adult | 2016 |
Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Area Under Curve; Bacterial Infections; Child; Dried Blood Spot Testing; Female; Humans; Macrolides; Male; Patient Safety; Triazoles | 2016 |
Ecological Effect of Solithromycin on Normal Human Oropharyngeal and Intestinal Microbiota.
Topics: Anti-Bacterial Agents; Bifidobacterium; Clostridioides difficile; Enterococcus; Feces; Female; Fusobacteria; Gastrointestinal Microbiome; Healthy Volunteers; Humans; Lactobacillus; Leptotrichia; Macrolides; Male; Microbial Sensitivity Tests; Microbiota; Oropharynx; Prevotella; Saliva; Streptococcus; Triazoles | 2016 |
SOLITAIRE-IV: A Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous-to-Oral Solithromycin to Intravenous-to-Oral Moxifloxacin for Treatment of Community-Acquired Bacterial Pneumonia.
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Community-Acquired Infections; Comorbidity; Drug Resistance, Bacterial; Female; Fluoroquinolones; Humans; Macrolides; Male; Microbial Sensitivity Tests; Middle Aged; Moxifloxacin; Pneumonia, Bacterial; Treatment Outcome; Triazoles | 2016 |
Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects.
Topics: Arrhythmias, Cardiac; Cross-Over Studies; Electrocardiography; Female; Fluoroquinolones; Healthy Volunteers; Heart Conduction System; Humans; Macrolides; Male; Moxifloxacin; Placebos; Triazoles | 2017 |
Population Pharmacokinetics and Safety of Solithromycin following Intravenous and Oral Administration in Infants, Children, and Adolescents.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Macrolides; Male; Middle Aged; Triazoles; Young Adult | 2018 |
Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.
Topics: Anti-Bacterial Agents; Antimicrobial Stewardship; Bacterial Vaccines; Barbiturates; Drug Resistance, Multiple, Bacterial; Epidemiological Monitoring; Gonorrhea; Group Processes; Humans; Isoxazoles; Macrolides; Microbial Sensitivity Tests; Morpholines; Mutation; Neisseria gonorrhoeae; Oxazolidinones; Public Health; Sexually Transmitted Diseases; Spiro Compounds; Topoisomerase Inhibitors; Triazoles; World Health Organization | 2019 |
Solithromycin versus ceftriaxone plus azithromycin for the treatment of uncomplicated genital gonorrhoea (SOLITAIRE-U): a randomised phase 3 non-inferiority trial.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Australia; Azithromycin; Ceftriaxone; Female; Gonorrhea; Humans; Injections, Intramuscular; Macrolides; Male; Neisseria gonorrhoeae; Treatment Outcome; Triazoles; United States | 2019 |
Solithromycin in Children and Adolescents With Community-acquired Bacterial Pneumonia.
Topics: Adolescent; Anti-Bacterial Agents; Child; Community-Acquired Infections; Humans; Macrolides; Pneumonia, Bacterial; Triazoles | 2022 |
55 other study(ies) available for triazoles and cem 101
| Article | Year |
|---|---|
In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Macrolides; Microbial Sensitivity Tests; Penicillin G; Streptococcus pneumoniae; Streptococcus pyogenes; Triazoles | 2010 |
CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria.
Topics: Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Macrolides; Microbial Sensitivity Tests; Molecular Structure; Triazoles | 2010 |
In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae.
Topics: Adult; Anti-Bacterial Agents; Child; Child, Preschool; Chlamydia Infections; Chlamydia trachomatis; Chlamydophila Infections; Chlamydophila pneumoniae; Female; Humans; Infant; Macrolides; Microbial Sensitivity Tests; Pneumonia, Bacterial; Triazoles | 2010 |
MIC quality control guidelines and disk diffusion test optimization for CEM-101, a novel fluoroketolide.
Topics: Anti-Bacterial Agents; Bacteria; Humans; Macrolides; Microbial Sensitivity Tests; Quality Control; Triazoles | 2010 |
CEM-101 activity against Gram-positive organisms.
Topics: Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Clarithromycin; Drug Resistance, Bacterial; Drug Synergism; Erythromycin; Gentamicins; Gram-Positive Bacteria; Ketolides; Macrolides; Microbial Sensitivity Tests; Ofloxacin; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pneumoniae; Streptococcus pyogenes; Triazoles; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin | 2010 |
Antimicrobial characterisation of CEM-101 activity against respiratory tract pathogens, including multidrug-resistant pneumococcal serogroup 19A isolates.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Community-Acquired Infections; Drug Resistance, Multiple, Bacterial; Humans; Macrolides; Microbial Sensitivity Tests; Respiratory Tract Infections; Triazoles | 2010 |
Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection.
Topics: Anti-Bacterial Agents; Azithromycin; Ceftriaxone; Ciprofloxacin; Humans; Ketolides; Macrolides; Microbial Sensitivity Tests; Minocycline; Neisseria meningitidis; Penicillins; Rifampin; Sulfamethoxazole; Triazoles; Trimethoprim | 2010 |
The in vitro evaluation of solithromycin (CEM-101) against pathogens isolated in the United States and Europe (2009).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Child; Child, Preschool; Europe; Humans; Infant; Infant, Newborn; Macrolides; Microbial Sensitivity Tests; Middle Aged; Triazoles; United States; Young Adult | 2010 |
Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.
Topics: Anti-Bacterial Agents; Chromatography, Gel; Deinococcus; Escherichia coli; Haloarcula marismortui; Macrolides; Molecular Structure; Protein Biosynthesis; Ribosomes; Staphylococcus aureus; Triazoles; X-Ray Diffraction | 2010 |
Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci.
Topics: Anti-Bacterial Agents; Enterococcus; Humans; Macrolides; Microbial Sensitivity Tests; Staphylococcus; Triazoles | 2011 |
In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species.
Topics: Animals; Antimalarials; Drug Resistance, Multiple; Humans; Macrolides; Malaria; Mice; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Triazoles | 2012 |
In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment op
Topics: Anti-Bacterial Agents; Cephalosporin Resistance; Cephalosporins; Culture Media; Drug Resistance, Multiple, Bacterial; Erythromycin; Humans; Macrolides; Microbial Sensitivity Tests; Molecular Structure; Neisseria gonorrhoeae; Triazoles | 2012 |
Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae.
Topics: Anti-Infective Agents; Haemophilus influenzae; Inhibitory Concentration 50; Macrolides; Protein Biosynthesis; Ribosomes; Staphylococcus aureus; Streptococcus pneumoniae; Triazoles | 2013 |
A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-8; Macrolides; Macrophages, Alveolar; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; NF-kappa B; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Tobacco Smoke Pollution; Triazoles; Tumor Necrosis Factor-alpha; U937 Cells | 2013 |
A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition.
Topics: Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Cells, Cultured; Dexamethasone; Drug Resistance; Histone Deacetylase 2; Humans; Hydrogen Peroxide; Interleukin-8; Leukocytes, Mononuclear; Macrolides; Male; Mice, Inbred C57BL; Neutrophils; Nicotiana; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Pulmonary Disease, Chronic Obstructive; Smoke; Triazoles; Tumor Necrosis Factor-alpha; U937 Cells | 2013 |
Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model.
Topics: Amniotic Fluid; Animals; Anti-Bacterial Agents; Female; Fetus; Humans; Macrolides; Pregnancy; Sheep; Triazoles | 2014 |
Antimicrobial activity of solithromycin against clinical isolates of Legionella pneumophila serogroup 1.
Topics: Anti-Bacterial Agents; Azithromycin; Cell Line, Tumor; Clinical Trials, Phase III as Topic; Epithelial Cells; Humans; Legionella pneumophila; Legionnaires' Disease; Macrolides; Microbial Sensitivity Tests; Serotyping; Triazoles | 2014 |
In vitro activity of solithromycin against erythromycin-resistant Streptococcus agalactiae.
Topics: Anti-Bacterial Agents; Disk Diffusion Antimicrobial Tests; Drug Resistance, Bacterial; Erythromycin; Genes, Bacterial; In Vitro Techniques; Macrolides; Microbial Sensitivity Tests; Multiplex Polymerase Chain Reaction; Streptococcus agalactiae; Triazoles | 2014 |
In vitro activity of the new fluoroketolide solithromycin (CEM-101) against macrolide-resistant and -susceptible Mycoplasma genitalium strains.
Topics: Anti-Bacterial Agents; Azithromycin; DNA, Bacterial; DNA, Ribosomal; Doxycycline; Drug Resistance, Bacterial; Fluoroquinolones; Gonorrhea; Humans; Macrolides; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Mycoplasma genitalium; Mycoplasma Infections; Neisseria gonorrhoeae; Triazoles | 2014 |
Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection.
Topics: Administration, Intravenous; Amniotic Fluid; Animals; Anti-Bacterial Agents; Azithromycin; Chemokine CCL2; Chemokine CCL8; Female; Fetus; Interleukins; Lung; Macrolides; Pneumonia; Pregnancy; Pregnancy Complications, Infectious; Sheep; Triazoles; Ureaplasma; Ureaplasma Infections | 2014 |
Trans-placental passage and anti-inflammatory effects of solithromycin in the human placenta.
Topics: Anti-Bacterial Agents; Female; Humans; Interleukin-6; Macrolides; Maternal-Fetal Exchange; Placenta; Pregnancy; Triazoles; Trophoblasts; Tumor Necrosis Factor-alpha | 2014 |
Antimicrobial activity of solithromycin against serotyped macrolide-resistant Streptococcus pneumoniae isolates collected from U.S. medical centers in 2012.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Community-Acquired Infections; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Humans; Macrolides; Microbial Sensitivity Tests; Penicillin Resistance; Pneumococcal Infections; Protein Tyrosine Phosphatases; Streptococcus pneumoniae; Triazoles; United States | 2015 |
Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms.
Topics: Aged; Aged, 80 and over; Albuterol; Anti-Bacterial Agents; Biofilms; Bronchodilator Agents; Chromatography, High Pressure Liquid; Drug Interactions; Female; Fluoroquinolones; Humans; Ipratropium; Macrolides; Male; Mass Spectrometry; Microbial Viability; Middle Aged; Models, Theoretical; Moxifloxacin; N-Acetylneuraminic Acid; Pneumococcal Infections; Streptococcus pneumoniae; Triazoles | 2015 |
Safety and Pharmacokinetics of Solithromycin in Subjects with Hepatic Impairment.
Topics: Adult; Aged; Area Under Curve; Body Mass Index; Case-Control Studies; Female; Humans; Liver; Liver Diseases; Macrolides; Male; Middle Aged; Triazoles | 2015 |
Solithromycin to treat community-acquired pneumonia?
Topics: Aged; Community-Acquired Infections; Humans; Macrolides; Pneumonia; Triazoles | 2015 |
In vitro activity of solithromycin and its metabolites, CEM-214 and N-acetyl-CEM-101, against 100 clinical Ureaplasma spp. isolates compared with azithromycin.
Topics: Anti-Bacterial Agents; Australia; Azithromycin; Drug Resistance, Bacterial; Female; Humans; Infant, Newborn; Macrolides; Microbial Sensitivity Tests; Pregnancy; Triazoles; United Kingdom; Ureaplasma; Ureaplasma Infections | 2015 |
Determination of Disk Diffusion and MIC Quality Control Guidelines for Solithromycin, a Novel Fluoroketolide Antibacterial, against Neisseria gonorrhoeae.
Topics: Anti-Bacterial Agents; Humans; Macrolides; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Quality Control; Triazoles | 2015 |
Type III Secretion-Dependent Sensitivity of Escherichia coli O157 to Specific Ketolides.
Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Caco-2 Cells; Cattle; Cell Line; Drug Discovery; Epithelial Cells; Escherichia coli O157; Gene Expression; High-Throughput Screening Assays; Humans; Ketolides; Macrolides; Microbial Sensitivity Tests; Respiratory Mucosa; Small Molecule Libraries; Triazoles; Type III Secretion Systems | 2016 |
Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry.
Topics: Alkynes; Anti-Bacterial Agents; Azides; Click Chemistry; Cycloaddition Reaction; Humans; Macrolides; Models, Molecular; Ribosomes; Thermodynamics; Triazoles | 2016 |
Results from the Solithromycin International Surveillance Program (2014).
Topics: Anti-Bacterial Agents; Asia; Azithromycin; Bacterial Infections; Community-Acquired Infections; Epidemiological Monitoring; Europe; Haemophilus influenzae; Humans; International Cooperation; Ketolides; Latin America; Macrolides; Microbial Sensitivity Tests; Moraxella catarrhalis; Staphylococcus aureus; Streptococcus; Streptococcus pneumoniae; Triazoles; United States | 2016 |
A platform for the discovery of new macrolide antibiotics.
Topics: Amino Sugars; Anti-Bacterial Agents; Bacteria; Drug Discovery; Humans; Ketolides; Macrolides; Microbial Sensitivity Tests; Molecular Structure; Small Molecule Libraries; Triazoles | 2016 |
Efficacy of Solithromycin (CEM-101) for Experimental Otitis Media Caused by Nontypeable Haemophilus influenzae and Streptococcus pneumoniae.
Topics: Animals; Anti-Bacterial Agents; Child, Preschool; Chinchilla; Ear, Middle; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Infant; Ketolides; Macrolides; Male; Microbial Sensitivity Tests; Otitis Media; Pneumococcal Infections; Streptococcus pneumoniae; Triazoles | 2016 |
In Vitro Activity of Solithromycin against Bordetella pertussis, an Emerging Respiratory Pathogen.
Topics: Anti-Bacterial Agents; Bordetella pertussis; Humans; Macrolides; Microbial Sensitivity Tests; Triazoles | 2016 |
Solithromycin for the treatment of community-acquired bacterial pneumonia.
Topics: Anti-Bacterial Agents; Community-Acquired Infections; Humans; Macrolides; Pneumonia, Bacterial; Streptococcus pneumoniae; Triazoles | 2017 |
Antimicrobials and QT prolongation.
Topics: Anti-Bacterial Agents; Education, Medical; Humans; Ketolides; Long QT Syndrome; Macrolides; Potassium Channels, Inwardly Rectifying; Practice Patterns, Physicians'; Torsades de Pointes; Triazoles | 2017 |
Solithromycin rejection chills antibiotic sector.
Topics: Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Humans; Macrolides; Triazoles; United States; United States Food and Drug Administration | 2017 |
Role of the N-acetylation polymorphism in solithromycin metabolism.
Topics: Acetylation; Arylamine N-Acetyltransferase; Hepatocytes; Humans; Isoenzymes; Macrolides; Polymorphism, Genetic; Triazoles | 2017 |
Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Area Under Curve; Bronchoalveolar Lavage Fluid; Community-Acquired Infections; Computer Simulation; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Injections, Intravenous; Macrolides; Models, Biological; Pneumonia, Bacterial; Predictive Value of Tests; Triazoles | 2017 |
Overcoming the Challenges of Low Drug Solubility in the Intravenous Formulation of Solithromycin.
Topics: Administration, Intravenous; Amino Acids; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Clinical Trials, Phase I as Topic; Community-Acquired Infections; Drug-Related Side Effects and Adverse Reactions; Humans; Macrolides; Solubility; Tartrates; Triazoles | 2018 |
The Effect of Solithromycin, a Cationic Amphiphilic Drug, on the Proliferation and Differentiation of Human Meibomian Gland Epithelial Cells.
Topics: Anti-Bacterial Agents; Cell Count; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Epithelial Cells; Eyelid Diseases; Humans; Lipid Metabolism; Macrolides; Meibomian Glands; Triazoles | 2018 |
Metabolism, Excretion, and Mass Balance of Solithromycin in Humans.
Topics: Adult; Anti-Bacterial Agents; Community-Acquired Infections; Cytochrome P-450 CYP3A; Humans; Macrolides; Male; Metabolic Clearance Rate; Microbial Sensitivity Tests; Middle Aged; Pneumonia, Bacterial; Triazoles; Young Adult | 2018 |
In vitro-induced erythromycin resistance facilitates cross-resistance to the novel fluoroketolide, solithromycin, in Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Binding Sites; Drug Resistance, Multiple, Bacterial; Erythromycin; Macrolides; Microbial Sensitivity Tests; Mutation; Staphylococcus aureus; Triazoles | 2018 |
Potency of Solithromycin against Fast- and Slow-Growing Chlamydial Organisms.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Chlamydia trachomatis; Interferon-gamma; Macrolides; Triazoles | 2018 |
Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens.
Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Enterococcus faecium; Escherichia coli; Macrolides; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus; Structure-Activity Relationship; Triazoles | 2019 |
Solithromycin for the treatment of drug-resistant gonorrhoea.
Topics: Azithromycin; Ceftriaxone; Genitalia; Gonorrhea; Humans; Macrolides; Triazoles | 2019 |
Erythromycin, Cethromycin and Solithromycin display similar binding affinities to the E. coli's ribosome: A molecular simulation study.
Topics: Binding Sites; Entropy; Erythromycin; Escherichia coli; Hydrogen Bonding; Ketolides; Macrolides; Methylation; Molecular Docking Simulation; Molecular Dynamics Simulation; Ribosomes; Static Electricity; Thermodynamics; Time Factors; Triazoles | 2019 |
A Dried Blood Spot Analysis for Solithromycin in Adolescents, Children, and Infants: A Short Communication.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Dried Blood Spot Testing; Humans; Infant; Infant, Newborn; Macrolides; Pneumonia, Bacterial; Triazoles | 2019 |
Phase 3 trial of treating gonorrhoea with solithromycin.
Topics: Azithromycin; Ceftriaxone; Genitalia; Gonorrhea; Humans; Macrolides; Triazoles | 2019 |
Should we fear gonorrhoea?
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Gonorrhea; Humans; Macrolides; Neisseria gonorrhoeae; Triazoles | 2019 |
Solithromycin Can Specifically Induce Macrolide-Lincosamide-Streptogramin B Resistance.
Topics: Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Clindamycin; Drug Resistance, Bacterial; Erythromycin; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Reporter; Genetic Engineering; Ketolides; Lac Operon; Lincosamides; Macrolides; Methyltransferases; Microbial Sensitivity Tests; Miocamycin; Staphylococcus aureus; Streptogramin B; Transformation, Bacterial; Triazoles | 2020 |
A novel macrolide, solithromycin suppresses mucin overexpression induced by Pseudomonas aeruginosa LPS in airway epithelial cells.
Topics: Epithelial Cells; Humans; Lipopolysaccharides; Macrolides; Pseudomonas aeruginosa; Triazoles | 2020 |
Comparison of solithromycin with erythromycin in Enterococcus faecalis and Enterococcus faecium from China: antibacterial activity, clonality, resistance mechanism, and inhibition of biofilm formation.
Topics: Anti-Bacterial Agents; Biofilms; China; Cross Infection; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Erythromycin; Linezolid; Macrolides; Microbial Sensitivity Tests; Triazoles; Vancomycin | 2021 |
Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Antifungal Agents; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Infant; Ketoconazole; Macrolides; Midazolam; Tandem Mass Spectrometry; Triazoles | 2021 |
Synthesis, Biological Evaluation, and Computational Analysis of Biaryl Side-Chain Analogs of Solithromycin.
Topics: Anti-Bacterial Agents; Density Functional Theory; Dose-Response Relationship, Drug; Escherichia coli; Macrolides; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Staphylococcus aureus; Structure-Activity Relationship; Triazoles | 2021 |
Alternative approaches utilizing click chemistry to develop next-generation analogs of solithromycin.
Topics: Anti-Bacterial Agents; Click Chemistry; Community-Acquired Infections; Humans; Macrolides; Microbial Sensitivity Tests; Triazoles | 2022 |