zoxamide

Description

Zoxamide is a fungicide with a broad spectrum of activity, particularly against Oomycetes, including Phytophthora and Pythium species. It is used to control diseases such as late blight of potato and tomato, downy mildew of grapevines, and damping-off of seedlings. Zoxamide has been shown to inhibit the growth of fungal hyphae and spores. Its mode of action is not fully understood but is thought to involve interference with mitochondrial respiration. Zoxamide is absorbed by plants through the roots and leaves, and is translocated throughout the plant. It is a relatively persistent fungicide in the environment and can be found in soil, water, and air. The synthesis of zoxamide involves a multi-step process that begins with the reaction of 2-chloro-6-fluorobenzonitrile with 2-methyl-1-propanol. The resulting intermediate is then reacted with 2-chloro-4-nitroaniline to produce zoxamide. Zoxamide is being studied for its potential to control emerging fungal diseases that are becoming resistant to other fungicides. It is also being investigated for its use in seed treatments to protect plants from fungal pathogens.'

zoxamide: no further info available 4/02 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

zoxamide : A racemate comprising equimolar amounts of (R)- and (S)-zoxamide. A fungicide used for the control of various fungal infections including blight in potatoes and tomatoes. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide : A member of the class of benzamides obtained by formal condensation of the carboxy group of 3,5-dichloro-4-methylbenzamide with the amino group of 3-amino-1-chloro-3-methylpentan-2-one. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]