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emtricitabine, tenofovir disoproxil fumarate drug combination

Description

Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination: A pharmaceutical preparation of emtricitabine and tenofovir that is used as an ANTI-HIV AGENT in the treatment and prevention of HIV INFECTIONS. [MeSH]

Cross-References

ID SourceID
PubMed CID11954236
SCHEMBL ID17373214
MeSH IDM000605888

Synonyms (15)

Synonym
emtricitabine / tenofovir disoproxil fumarate
emtricitabine and tenofovir disoproxil fumarate
emtricitabine, tenofovir disoproxil fumarate drug combination
tenofovir disoproxil fumarate/emtricitabine
emtricitabine and tenofovir
731772-45-5
emtricitabine / tenofovir
tenofovir / emtricitabine
SCHEMBL17373214
emtricitabine tenofovir df
VERWQPYQDXWOGT-LVJNJWHOSA-N
emtricitabine tenofovir disoproxil fumarate
Q2412859
tenofovir/emtricitabine
4-amino-5-fluoro-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;[[(2r)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;(e)-but-2-enedioic acid

Research

Studies (239)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's20 (8.37)29.6817
2010's191 (79.92)24.3611
2020's28 (11.72)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials31 (12.20%)5.53%
Reviews25 (9.84%)6.00%
Case Studies14 (5.51%)4.05%
Observational4 (1.57%)0.25%
Other180 (70.87%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
adenine6-aminopurines;
purine nucleobase
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2005202111.3low2009152
albendazolearyl sulfide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester
anthelminthic drug;
microtubule-destabilising agent;
tubulin modulator
202020204.0low000010
nevirapinecyclopropanes;
dipyridodiazepine
antiviral drug;
HIV-1 reverse transcriptase inhibitor
2011201610.6low200050
probenecidbenzoic acids;
sulfonamide
uricosuric drug202020204.0low100020
pyrimethamineaminopyrimidine;
monochlorobenzenes
antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
202020204.0low000010
prednisolone11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic
201520159.0low000010
alaninealanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid
EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
201220215.7low100042
carbostyrilmonohydroxyquinoline;
quinolone
bacterial xenobiotic metabolite2009201014.5low000200
methamphetamineamphetamines;
secondary amine
central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic
201820233.5low000011
deoxycytidinepyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2004201512.5medium40026750
stavudinedihydrofuran;
nucleoside analogue;
organic molecular entity
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
2013201311.0low000010
cetylpyridinium chloride anhydrouschloride salt;
organic chloride salt
antiseptic drug;
surfactant
2011201113.0low000010
zidovudineazide;
pyrimidine 2',3'-dideoxyribonucleoside
antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
2007202011.0low100250
cidofovir anhydrousphosphonic acids;
pyrimidone
anti-HIV agent;
antineoplastic agent;
antiviral drug;
photosensitizing agent
202220222.0low000001
lamivudinemonothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol
allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
2004202212.8low200851
emtricitabinemonothioacetal;
nucleoside analogue;
organofluorine compound;
pyrimidone
antiviral drug;
HIV-1 reverse transcriptase inhibitor
200520238.0low200498
efavirenzacetylenic compound;
benzoxazine;
cyclopropanes;
organochlorine compound;
organofluorine compound
antiviral drug;
HIV-1 reverse transcriptase inhibitor
200720209.6low300140
triazoles1,2,3-triazole201620177.5low200020
lopinaviramphetamines;
dicarboxylic acid diamide
anticoronaviral agent;
antiviral drug;
HIV protease inhibitor
201220179.5low200060
atazanavir sulfateorganic sulfate salt2010201910.0low200130
combivir2007202010.6low100230
organophosphonatesdivalent inorganic anion;
phosphite ion
2005202212.9low0009101
darunavircarbamate ester;
furofuran;
sulfonamide
antiviral drug;
HIV protease inhibitor
201420198.0low100030
ritonavir1,3-thiazoles;
carbamate ester;
carboxamide;
L-valine derivative;
ureas
antiviral drug;
environmental contaminant;
HIV protease inhibitor;
xenobiotic
200920219.4low4002111
linezolidacetamides;
morpholines;
organofluorine compound;
oxazolidinone
antibacterial drug;
protein synthesis inhibitor
202020204.0low000010
tenofovirnucleoside analogue;
phosphonic acids
antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
200520238.3low7007249
maraviroctropane alkaloid201620177.5low200020
abacavir, lamivudine drug combination2004201714.8low100320
jtk-303aromatic ether;
monochlorobenzenes;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone
HIV-1 integrase inhibitor2009201014.5low000200
fumaratesbutenedioate;
C4-dicarboxylate
human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite
202220222.0low000001
rilpivirineaminopyrimidine;
nitrile
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor
2009202210.3low000201
gs-73406-aminopurines;
ether;
isopropyl ester;
L-alanine derivative;
phosphoramidate ester
antiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug
201220215.7low100042
efavirenz, emtricitabine, tenofovir disoproxil fumarate drug combination2009201213.7low000210
raltegravir potassium200820199.3low3001100
ro13-9904201920195.0low000010
combivent respimat201820186.0low100010
cobicistat1,3-thiazoles;
carbamate ester;
monocarboxylic acid amide;
morpholines;
ureas
P450 inhibitor201920214.0low100011
quad pill201820224.0low000011
sofosbuvirisopropyl ester;
L-alanyl ester;
nucleotide conjugate;
organofluorine compound;
phosphoramidate ester
antiviral drug;
hepatitis C protease inhibitor;
prodrug
202020204.0low000010
gsk1265744difluorobenzene;
monocarboxylic acid amide;
organic heterotricyclic compound;
secondary carboxamide
HIV-1 integrase inhibitor201520215.0low000031
dolutegravirdifluorobenzene;
monocarboxylic acid amide;
organic heterotricyclic compound;
secondary carboxamide
HIV-1 integrase inhibitor201720177.0low000010
levoleucovorin5-formyltetrahydrofolic acidantineoplastic agent;
metabolite
201720177.0low000010
sildenafil citratecitrate saltEC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor;
vasodilator agent
201820186.0low000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
2019 Novel Coronavirus Disease0202020204.0low000010
Abnormalities, Congenital, Nervous System02011201113.0low000010
Acquired Immune Deficiency Syndrome0200420238.8low100161
Acquired Immunodeficiency Syndrome0200420238.8low100161
Acquired-Immune Deficiency Syndrome Dementia Complex0201520159.0low000010
Acute Disease0201720177.0low000010
Acute Liver Injury, Drug-Induced02013201311.0low000010
AIDS Dementia Complex0201520159.0low000010
AIDS Seroconversion0201320216.3low100051
AIDS-Related Opportunistic Infections0201720177.0low000010
AIDS, Simian02010202010.5low0001100
Allergy, Drug02005200718.0low000200
Arrhythmia0201520159.0low000010
Arrhythmias, Cardiac0201520159.0low000010
Autoimmune Disease02011201113.0low000010
Autoimmune Diseases02011201113.0low000010
Autoimmune Diseases of the Nervous System02011201113.0low000010
Bacterial Sexually Transmitted Disease0201920195.0low000010
Bacterial Vaginitides0201820186.0low100010
Biliary Cirrhosis0201520159.0low000010
Bone Diseases0201820186.0low000010
Cancer of Ovary02012201212.0low000010
Carditis02011201511.0low000020
Central Nervous System Toxoplasmosis0201720177.0low000010
Chemical and Drug Induced Liver Injury02013201311.0low000010
Chemical Dependence0201620196.5low200020
Chlamydia Infections0201620168.0low000010
Cholangitis0201520159.0low000010
Cholera Infantum02007200717.0low000100
Chronic Disease02012201212.0low000010
Chronic Hepatitis B0201520168.5low100020
Chronic Hepatitis C02013201311.0low000010
Chronic Illness02012201212.0low000010
Chronic Insomnia02008200816.0low000100
Co-infection0201320198.0low000030
Cognition Disorders0201620168.0low100010
Coma0201520159.0low000010
Communicable Diseases0202020204.0low000010
Complications, Infectious Pregnancy0201620187.0low000020
Congenital Zika Syndrome0201620168.0low000010
Coronavirus Infections0202020204.0low000010
Dermatitis, Atopic0201520159.0low000010
Disease Models, Animal0201020208.7low000150
Diseases, Occupational0201720177.0low000010
Drug Hypersensitivity02005200718.0low000200
Ebola Hemorrhagic Fever0201620168.0low000010
Eczema, Atopic0201520159.0low000010
Edema, Pulmonary0201520159.0low000010
Esophagitis0202220222.0low000001
Fibroma, Shope0201520159.0low000010
Genital Herpes0201820186.0low100010
Great Pox0201920195.0low000010
Hemorrhagic Fever, Ebola0201620168.0low000010
Hepatitis B0201520226.2low000032
Hepatitis B Virus Infection0201520226.2low000032
Hepatitis B, Chronic0201520168.5low100020
Hepatitis C0201520178.0low000030
Hepatitis C, Chronic02013201311.0low000010
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted0201520178.0low000030
Herpes Genitalis0201820186.0low100010
HIV0200920219.8low200372
HIV Coinfection0200420238.8high27002217217
HIV Infections0200420238.8high27002217217
Infections, Chlamydia0201620168.0low000010
Infections, Coronavirus0202020204.0low000010
Infections, Retroviridae0201520159.0low000010
Infectious Diseases0202020204.0low000010
Injuries, Needlestick0201420178.7low000030
Kidney Diseases0201620187.0low100020
Kidney Failure0201920204.5low000020
Libman-Sacks Disease02011201113.0low000010
Lipodystrophy02008200816.0low000100
Liver Cirrhosis, Biliary0201520159.0low000010
Lupus Erythematosus, Systemic02011201113.0low000010
Muscle Disorders0201520159.0low000010
Muscular Diseases0201520159.0low000010
Myocarditis02011201511.0low000020
Ovarian Neoplasms02012201212.0low000010
Pneumonia, Viral0202020204.0low000010
Pregnancy0201320217.0low000031
Pulmonary Edema0201520159.0low000010
Renal Insufficiency0201920204.5low000020
Retroviridae Infections0201520159.0low000010
Sexually Transmitted Diseases0201220179.5low000020
Sexually Transmitted Diseases, Bacterial0201920195.0low000010
Skin Syphilis0201920195.0low000010
Sleep Initiation and Maintenance Disorders02008200816.0low000100
Substance-Related Disorders0201620196.5low200020
Syphilis0201920195.0low000010
Toxoplasmosis, Cerebral0201720177.0low000010
Trichomonas Vaginitis0201620168.0low000010
Trichomoniasis, Human0201620168.0low000010
Vaginosis, Bacterial0201820186.0low100010
Viremia02012201511.0low000030
Zika Virus Infection0201620168.0low000010

Safety/Toxicity (8)

ArticleYear
Comparison of the efficacy, safety and durability of a switch to co-formulated RPV/TDF-TAF/FTC or DTG/ABC/3TC in virologically-suppressed HIV-1-infected patients in a single Italian centre: a cohort data analysis.
International journal of antimicrobial agents, , Volume: 59, Issue:1
2022
Week 96 efficacy and safety results of the phase 3, randomized EMERALD trial to evaluate switching from boosted-protease inhibitors plus emtricitabine/tenofovir disoproxil fumarate regimens to the once daily, single-tablet regimen of darunavir/cobicistat/
Antiviral research, , Volume: 170
2019
Safety and Feasibility of Antiretroviral Preexposure Prophylaxis for Adolescent Men Who Have Sex With Men Aged 15 to 17 Years in the United States.
JAMA pediatrics, , 11-01, Volume: 171, Issue:11
2017
Pre-Exposure Prophylaxis for HIV Prevention: Safety Concerns.
Drug safety, , Volume: 40, Issue:4
2017
Drug safety evaluation of oral tenofovir disoproxil fumarate-emtricitabine for pre-exposure prophylaxis for human immunodeficiency virus infection.
Expert opinion on drug safety, , Volume: 15, Issue:9
2016
The Safety of Tenofovir-Emtricitabine for HIV Pre-Exposure Prophylaxis (PrEP) in Individuals With Active Hepatitis B.
Journal of acquired immune deficiency syndromes (1999), , 03-01, Volume: 71, Issue:3
2016
A randomised comparison of safety and efficacy of nevirapine vs. atazanavir/ritonavir combined with tenofovir/emtricitabine in treatment-naïve patients.
International journal of clinical practice, , Volume: 65, Issue:12
2011
Effectiveness and safety of simplification from tenofovir-lamivudine (TDF-3TC) to tenofovir-emtricitabine (TDF-FTC) co-formulation (Truvada) in virologically suppressed HIV-infected patients on HAART.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, , Volume: 28, Issue:4
2009

Pharmacokinetics (2)

ArticleYear
Probenecid-Boosted Tenofovir: A Physiologically-Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis.
CPT: pharmacometrics & systems pharmacology, , Volume: 9, Issue:1
2020
Comprehensive Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Evaluation of Once-Daily Efavirenz 400 and 600 mg in Treatment-Naïve HIV-Infected Patients at 96 Weeks: Results of the ENCORE1 Study.
Clinical pharmacokinetics, , Volume: 55, Issue:7
2016

Bioavailability (2)

ArticleYear
The Elegance of the Acyclic Nucleoside Phosphonates (ANPs), Honorary Tribute to Antonín Holý, Who Passed Away on 16 July 2012, at the 10th Anniversary of His Death.
Viruses, , 09-07, Volume: 14, Issue:9
2022
Comparative bioavailability of two tablet formulations of emtricitabine/tenofovir in healthy, fasting volunteers: a single-dose, randomized-sequence, open-label crossover study.
International journal of clinical pharmacology and therapeutics, , Volume: 54, Issue:10
2016

Dosage (9)

ArticleYear
Low Disclosure of PrEP Nonadherence and HIV-Risk Behaviors Associated With Poor HIV PrEP Adherence in the HPTN 067/ADAPT Study.
Journal of acquired immune deficiency syndromes (1999), , 09-01, Volume: 82, Issue:1
2019
Recent advances in pre-exposure prophylaxis for HIV.
BMJ (Clinical research ed.), , 12-11, Volume: 359
2017
Characterization of HIV Seroconverters in a TDF/FTC PrEP Study: HPTN 067/ADAPT.
Journal of acquired immune deficiency syndromes (1999), , 07-01, Volume: 75, Issue:3
2017
The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challenge.
Science translational medicine, , Jan-14, Volume: 7, Issue:270
2015
A polyvalent Clade B virus-like particle HIV vaccine combined with partially protective oral preexposure prophylaxis prevents simian-human immunodeficiency virus Infection in macaques and primes for virus-amplified immunity.
AIDS research and human retroviruses, , Volume: 30, Issue:11
2014
Prevention of vaginal SHIV transmission in macaques by a coitally-dependent Truvada regimen.
PloS one, , Volume: 7, Issue:12
2012
High acceptability of HIV pre-exposure prophylaxis but challenges in adherence and use: qualitative insights from a phase I trial of intermittent and daily PrEP in at-risk populations in Kenya.
AIDS and behavior, , Volume: 17, Issue:6
2013
Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.
Science translational medicine, , Jan-13, Volume: 2, Issue:14
2010
Two-once-daily fixed-dose NRTI combinations for HIV.
The Medical letter on drugs and therapeutics, , Feb-28, Volume: 47, Issue:1203
2005

Interactions (2)

ArticleYear
Pharmacology and drug interactions with HIV PrEP in transgender persons receiving gender affirming hormone therapy.
Expert opinion on drug metabolism & toxicology, , Volume: 16, Issue:6
2020
A randomised comparison of safety and efficacy of nevirapine vs. atazanavir/ritonavir combined with tenofovir/emtricitabine in treatment-naïve patients.
International journal of clinical practice, , Volume: 65, Issue:12
2011