Page last updated: 2024-09-27

Toxocariasis

Infection by round worms of the genus TOXOCARA, usually found in wild and domesticated cats and dogs and foxes, except for the larvae, which may produce visceral and ocular larva migrans in man.

Synonyms(1)

Synonym
Toxocariasis

Research Excerpts

Overview

ExcerptReference
"Toxocariasis is an infrequent disease which particularly affects children."( Bruart, J; Henneghien, C; Jonckheer, J; Remacle, P, 1987)
"Ocular toxocariasis is rare and therefore the spectrum of clinical disease is difficult to establish."( Crowcroft, NS; Dinning, WJ; Gillespie, SH; Voller, A, 1993)
"Ocular toxocariasis is a rare infection caused by the nematode larvae of toxocara canis, which is commonly found in dogs."( Lampariello, DA; Primo, SA, 1999)
"Toxocariasis is usually manifested as visceral larva migrans."( Seguro, AC; Sztajnbok, J; Vidal, JE, 2003)
"Human toxocariasis is a helminthozoonosis caused by Toxocara sp."( Ashwath, ML; Katner, HP; Robinson, DR, 2004)
"Toxocariasis is a common helminth infection that causes visceral larva migrans in humans."( Bredin, C; Carrere, C; Casassus-Builhe, D; Froment, N; Rey, P, 2005)
"Toxocariasis is one of the causes of eosinophilia in peripheral blood and provokes eosinophilic infiltration in internal organs."( Choi, DC; Kwon, NH; Lee, BJ; Lee, SP; Oh, MJ, 2006)
"Toxocariasis is an important zoonotic disease caused by the second stage larva of Toxocara canis or Toxocara cati ."( Ahmad, Z; Fomda, BA; Khan, NN; Tanveer, S; Wani, SA, 2007)
"Human toxocariasis is caused by infection with the larval stage of nematode parasites of dogs and cats, Toxocara canis or Toxocara cati."( Colomba, C; Giordano, S; Infurnari, L; Saporito, L; Scarlata, F; Titone, L, 2008)
"Toxocariasis is one of the common causes of hyperIgEaemia that may lead to neurologic manifestations."( Choi, DC; Jeung, YJ; Kim, BJ; Lee, BJ; Lee, JY; Lee, SP; Oh, MJ; Paeng, JW; Park, MS, 2009)
"Toxocariasis is a zoonotic helminthic infection of humans caused by the dog roundworm (Toxocara canis) or cat roundworm (Toxocara cati)."( Lim Y, AL; Nor Azah, MO; Rahmah, N; Rohela, M; Romano, N, 2010)
"Visceral toxocariasis is a serious public health problem with a cosmopolitan distribution."( Berne, ME; Conceição, FR; da Costa de Avila, LF; da Fonseca, JS; da Silva, PE; de Lima Telmo, P; Dutra, GF; Scaini, CJ; Silva, AM, 2012)
"Toxocariasis is a parasitic disease caused by Toxocara canis or T."( Boujaoude, Z; Mian, A; Ranasuriya, G; Tsigrelis, C, 2014)
"Although neurotoxocariasis is defined as the fourth syndrome of toxocariasis, it is usually considered as a neurological disease which is usually concomitant with visceral larva migrans."( Arda, B; Erdem Kivrak, E; Işikgöz Taşbakan, M; Korkmaz, M; Pullukçu, H; Sıpahi, OR; Ulusoy, S; Yamazhan, T, 2014)
"Toxocariasis is a worldwide human helminthiasis, especially seen in temperate and tropical climate regions around the world."( Acar, A; Aydın, E; Görenek, L; Hatipoğlu, M; Karagöz, E; Öncül, O; Selek, MB; Turhan, V, 2015)
"Toxocariasis is a cosmopolitan zoonotic disease caused by the infective larvae of Toxocara canis and T."( Moghaddam, MH; Noordin, R; Rahumatullah, A; Sadjjadi, SM; Saidin, S; Yunus, MH; Zahabiun, F, 2015)
"Ocular Toxocariasis is a parasitosis caused by Toxocara catis/canis larvae localized in the eye."( Brănişteanu, D; Costin, D; Moraru, A; Panfil, M; Schmitzer, S; Totolici, G, 2014)
"Toxocariasis is a widespread zoonotic disease caused by the nematode Toxocara canis."( Corrales, Y; Ferrer, E; Figuera, L; García, H; González, V; Lamas, F; Lares, M; López, K; Martínez, M; Mijares, V, 2015)
"Ocular toxocariasis is caused by migration of a Toxocara larva through the posterior eye."( Hua, HY; Wang, W; Zhang, HF, 2015)
"Toxocariasis is a parasitic disease caused by the larval stage of Toxocara cati and T."( Avcı Merdin, F; Çiçek Kolak, Ç; Merdin, A; Ogur, E, 2016)
"Toxocariasis is a common zoonosis caused by infection with Toxocara canis or cati larvae."( Antonowicz, A; Kępa, B; Pańczyk-Tomaszewska, M; Skrzypczyk, P, 2016)
"Toxocariasis is a zoonotic disease that occurs when humans are infected by the parasites Toxocara canis or Toxocara cati."( Delaloye, J; Duréault, A; Manuel, O; Ogna, A; Perez Valdes, C; Sempoux, C; Weber, L, 2017)
"Toxocariasis is one of the most common neglected infections of poverty in the U."( Beltran, T; Choi, YS; Farmer, A, 2017)
"Toxocariasis is a worldwide zoonotic parasitic disease caused by species of Toxocara and Toxascaris, common in dogs and cats."( Badri, M; Eslahi, AV; Firoozeh, F; Foroutan, M; Hooshmand, E; Hosseini, H; Khorshidi, A; Majidiani, H; Pestehchian, N; Riahi, SM; Taghipour, A; Zibaei, M, 2020)
"Toxocariasis is a helminthozoonosis caused by the infection of a human host by the larva of Toxocara spp."( Agapiou, E; Mavridis, IN; Meliou, M; Pyrgelis, ES, 2020)
"Human neurotoxocariasis is a relatively rare entity yet associated with severe sequelae."( Agapiou, E; Mavridis, IN; Meliou, M; Pyrgelis, ES, 2020)
"BACKGROUND Toxocariasis is an infection due to ingestion of the helminth parasite larvae found in dogs (Toxocara canis) or cats (Toxocara cati)."( Bae, JH; Jang, CW; Kim, KH; Kim, YK; Kwon, TG; Park, SJ; Seo, YH, 2021)
"Human toxocariasis is a widespread zoonosis for which a chemotherapy decision and therapy effectiveness are difficult to determine."( Hai, TX; Le, TA; Loi, CB; Phuc, LDV; Quang, HH; Vinh, LD, 2021)
"Toxocariasis is a helminthic infection caused by a nematode that mainly affects populations in tropical and subtropical latitudes."( Gimeno Hernández, J; Gomez Serrano, M; Hernanperez Hidalgo, DM; Iglesias Moreno, MC; Jimenez Rodriguez-Madridejos, R; Merino Menendez, S, 2021)
"Toxocariasis is one of the most common geohelminth infections in several parts of the world."( Cai, Y; Yang, Y; Zhong, X, 2022)
"Toxocariasis is a zoonotic disease of worldwide distribution."( Avila, LFDC; Berne, MEA; Borchardt, JL; Leite, FPL; Moura, MQ; Pinheiro, NB; Santos, FDS; Terto, WDS; Villela, MM, 2022)
"Toxocariasis is a common parasitic infection worldwide."( Kim, IO; Kim, K; Lee, Y; Phi, JH; Song, YS, 2023)
"Toxocariasis is a cosmopolitan helminthiasis linked to contamination with Toxocara cati or Toxocara canis."( Bergues, B; Cornu, M; Deleplancque, AS; Hirabidian, M; Leroy, J; Loridant, S; Sendid, B; Thierry, S, 2023)

Context

ExcerptReference
"Toxocariasis has to be considered in travelers returning from a (sub)tropical stay with varying clinical manifestations or eosinophilia."( Bottieau, E; Clerinx, J; Jacobs, J; Kanobana, K; Polman, K; Soentjens, P; Theunissen, C; Van Den Broucke, S; Van Den Ende, J; Van Den Enden, E; Van Esbroeck, M; Van Gompel, A; Vekemans, M; Vlieghe, E, 2015)
"Ocular toxocariasis has a varied presentation spectrum."( Biswas, J; Pal, B; Sahu, ES; Sharma, T, 2018)

Treatment

ExcerptReference
"Unfortunately, the available drugs to treat toxocariasis are limited with unsatisfactory results, because of the initiation of treatment at late chronic stages after the occurrence of tissue damage and scars."( Afifi, AF; Beshay, EVN; El-Refai, SA; Elbadry, AA; Sadek, GS; Shalan, FH, 2020)

Research

Studies (413)

TimeframeStudies, This Condition (%)All Conditions %
pre-199085 (20.58)23.3326
1990's69 (16.71)12.5806
2000's121 (29.30)18.1394
2010's104 (25.18)28.8240
2020's34 (8.23)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
formaldehyde0low10
histamine0low40
nitrates0low10
nitrites0low10
4-aminobenzoic acid0low10
phosphorylcholine0low10
mercaptoethanol0low20
chlorocresol0low10
pimagedine0low10
cimetidine0low10
clobazam0low10
dapsone0low10
dichlorvos0low10
diethylcarbamazine0medium193
erythrosine0low10
fenbendazole0medium154
fipronil0low10
gabapentin0low10
hydroxychloroquine0low10
2-propanol0low20
tetramisole0low10
mebendazole0medium211
metformin0low10
niclosamide0low10
oxibendazole0medium11
piperazine0medium41
praziquantel0medium125
pyrilamine0low10
thiabendazole0medium211
tinidazole0low10
corticosterone0low10
prednisolone0low130
carbachol0low30
prednisone0low90
serine0low10
lysine0low10
niridazole0low10
threonine0low10
methylprednisolone0low30
thiophenes0low20
piperazine adipate0medium11
isoxazoles0low10
oxazoles0low10
thiazoles0low10
nitroblue tetrazolium0low10
perfluorooctane0low10
evans blue0low10
haloxon0low10
betamethasone0low20
azomycin0low10
oxophenarsine0low10
lucanthone hydrochloride0low10
chlorphenamidine0low10
gadolinium0low10
gold0low10
sodium nitrate0low10
zinc sulfate0low10
ozone0low10
levamisole0low50
cromolyn sodium0low20
tetradecanoylphorbol acetate0low30
fenitrothion0low10
phenyl acetate0low10
cetylpyridinium chloride anhydrous0low10
triamcinolone0low10
tetrachloroethylene0low10
benzonidazole0low10
tramadol0low10
flubendazole0low40
substance p0low10
amidantel0low10
oxfendazole0low10
nitazoxanide0low10
propiconazole0low10
dexamethasone trimethyl acetate0low10
triazoles0low10
nitroscanate0medium21
toltrazuril0medium22
fluphenacur0medium11
tebuconazole0low20
foxes0low240
p-methoxy-n-methylphenethylamine0low10
methotrexate0low10
xylose0low10
betamethasone-17,21-dipropionate0low10
naproxen0low10
paromomycin0low10
santonin0low10
cortisone0low20
elastin0low10
epiglucan0low20
laminaran0low10
retinol0low10
tacrolimus0low10
isomethyleugenol0low10
pyrantel0medium122
pica0low100
ovalbumin0low30
l 6635360low10
dinoprostone0low10
leukotriene b40low10
retinol palmitate0low10
pyrantel pamoate0medium133
tranilast0low10
lysophosphatidylcholines0low10
lead0low20
arsenic0low10
indium0low10
methoprene0low10
selenium0low10
ono 40570low10
bay 44-44000medium74
phoxim0low10
mocetinostat0low10
doramectin0low30
dextrothyroxine0medium257
indocyanine green0low20
clove0low10
protectin d10low10
sodium hypochlorite0low10
interleukin-80low10
tetracycline0low10
warfarin0low10
transforming growth factor beta0low20
tcv 3090low10
agar0low10
moxidectin0medium123
selamectin0medium43
cyclosporine0low30
exudates0low60
trypan blue0low20
febantel0medium61
imidacloprid0medium21
eye0low230
concanavalin a0low10

Protein Targets (798)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit110011
RAR-related orphan receptor gamma230023
GLI family zinc finger 3310031
AR protein490049
aldehyde dehydrogenase 1 family, member A1190019
retinoic acid nuclear receptor alpha variant 1330033
retinoid X nuclear receptor alpha310031
estrogen nuclear receptor alpha540054
peroxisome proliferator-activated receptor delta180018
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a290029
activating transcription factor 6110011
v-jun sarcoma virus 17 oncogene homolog (avian)190019
Histone H2A.x130013
thyroid hormone receptor beta isoform a100010
heat shock protein beta-1170017
nuclear factor erythroid 2-related factor 2 isoform 1280028
lamin isoform A-delta10230023
Voltage-dependent calcium channel gamma-2 subunit160016
Glutamate receptor 2160016
Chain A, Putative fructose-1,6-bisphosphate aldolase6006
Chain A, JmjC domain-containing histone demethylation protein 3A3003
phosphopantetheinyl transferase100010
bromodomain adjacent to zinc finger domain 2B100010
euchromatic histone-lysine N-methyltransferase 2230023
pyruvate kinase PKM isoform a2002
geminin300030
Glycoprotein hormones alpha chain1001
Guanine nucleotide-binding protein G4004
Tubulin--tyrosine ligase0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE170017
Genome polyprotein 0011
USP1 protein, partial180018
thyroid stimulating hormone receptor170017
glucocorticoid receptor [Homo sapiens]360036
chromobox protein homolog 1120012
transcriptional regulator ERG isoform 34004
Polyphenol oxidase 20102
Cellular tumor antigen p53300030
Thiopurine S-methyltransferase0101
Succinate-semialdehyde dehydrogenase, mitochondrial0101
4-aminobutyrate aminotransferase, mitochondrial0102
Cytochrome P450 1B10101
Dihydropteroate synthase 0011
Chain A, Beta-lactamase100010
Luciferase110011
glp-1 receptor, partial6006
ATAD5 protein, partial110011
Fumarate hydratase8008
TDP1 protein350035
caspase 7, apoptosis-related cysteine protease5005
nuclear receptor subfamily 1, group I, member 3230023
progesterone receptor230023
estrogen-related nuclear receptor alpha400040
farnesoid X nuclear receptor200020
pregnane X nuclear receptor350035
polyprotein8008
67.9K protein7007
peroxisome proliferator activated receptor gamma220022
vitamin D (1,25- dihydroxyvitamin D3) receptor260026
caspase-35005
IDH18008
aryl hydrocarbon receptor210021
nuclear receptor subfamily 1, group I, member 29009
cellular tumor antigen p53 isoform a8008
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
nuclear factor erythroid 2-related factor 2 isoform 29009
thyroid hormone receptor beta isoform 2320032
histone deacetylase 9 isoform 38008
mitogen-activated protein kinase 1140014
urokinase-type plasminogen activator precursor5005
plasminogen precursor5005
urokinase plasminogen activator surface receptor precursor5005
Vif0001
peripheral myelin protein 22200020
survival motor neuron protein isoform d150015
muscleblind-like protein 1 isoform 1100010
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
neuropeptide S receptor isoform A7007
ATP-binding cassette sub-family C member 3018018
Multidrug resistance-associated protein 4018020
Bile salt export pump028028
Interferon beta260026
Integrin beta-36006
Integrin alpha-IIb6006
Methionine aminopeptidase0404
Fatty-acid amide hydrolase 10404
Inositol monophosphatase 13003
Canalicular multispecific organic anion transporter 1018018
ATPase family AAA domain-containing protein 5190019
Ataxin-2200020
EWS/FLI fusion protein170017
Spike glycoprotein121114
thioredoxin reductase140014
cytochrome P450 family 3 subfamily A polypeptide 4200020
Glyceraldehyde-3-phosphate dehydrogenase0101
Cytochrome P450 1A20202
Cytochrome P450 3A40516
Cytochrome P450 2D60404
Cytochrome P450 2C9 0707
Cytochrome P450 2C190202
Potassium voltage-gated channel subfamily H member 20505
Aurora kinase B0101
pregnane X receptor110011
galanin receptor type 30101
Glucocorticoid receptor012219
Glycine receptor subunit alpha-1012012
Glycine receptor subunit beta012012
Glycine receptor subunit alpha-2012012
Glycine receptor subunit alpha-3012012
ORF730011
acetylcholinesterase120012
GALC protein6006
thyroid stimulating hormone receptor110011
thyrotropin-releasing hormone receptor4004
Bloom syndrome protein isoform 1110011
Neuronal acetylcholine receptor subunit alpha-30101
Muscarinic acetylcholine receptor M20528
Muscarinic acetylcholine receptor M40326
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30214
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M50203
Muscarinic acetylcholine receptor M50326
Neuronal acetylcholine receptor subunit alpha-40101
Muscarinic acetylcholine receptor M20203
Muscarinic acetylcholine receptor M10326
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30326
Neuronal acetylcholine receptor subunit alpha-50101
Delta-type opioid receptor0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Sigma non-opioid intracellular receptor 10011
Muscarinic acetylcholine receptor0202
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100101
Chain A, Ferritin light chain110011
SMAD family member 2150015
SMAD family member 3150015
Microtubule-associated protein tau130013
estrogen receptor 2 (ER beta)160016
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)7007
vitamin D3 receptor isoform VDRA140014
nuclear receptor ROR-gamma isoform 1160016
Caspase-20011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
G170017
HLA class I histocompatibility antigen, B alpha chain 170017
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Nuclear receptor ROR-gamma120012
Inositol hexakisphosphate kinase 1170017
cytochrome P450 2C9, partial170017
interleukin 84004
cytochrome P450 2D6130013
arylsulfatase A6006
alpha-galactosidase2002
cytochrome P450 2C19 precursor4004
DNA polymerase kappa isoform 1130013
cytochrome P450 3A4 isoform 1210021
M-phase phosphoprotein 87007
muscarinic acetylcholine receptor M18008
Solute carrier family 22 member 10101
Gamma-aminobutyric acid receptor subunit pi213024
Solute carrier family 22 member 20407
Solute carrier family 22 member 1 0608
Solute carrier family 22 member 60303
Solute carrier family 22 member 20101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10101
Gamma-aminobutyric acid receptor subunit beta-1213024
Gamma-aminobutyric acid receptor subunit delta213024
Gamma-aminobutyric acid receptor subunit gamma-2213125
Gamma-aminobutyric acid receptor subunit alpha-5213024
Gamma-aminobutyric acid receptor subunit alpha-3213024
Potassium-transporting ATPase alpha chain 10101
ATP-dependent translocase ABCB10101
Gamma-aminobutyric acid receptor subunit gamma-1213024
Gamma-aminobutyric acid receptor subunit alpha-2213024
Histamine H2 receptor0325
Gamma-aminobutyric acid receptor subunit alpha-4213024
Gamma-aminobutyric acid receptor subunit gamma-3213024
Gamma-aminobutyric acid receptor subunit alpha-6213024
Histamine H1 receptor0246
Histamine H2 receptor62210
Potassium-transporting ATPase subunit beta0101
Cytochrome P450 2J20404
Gamma-aminobutyric acid receptor subunit alpha-1213125
Gamma-aminobutyric acid receptor subunit beta-3213024
Gamma-aminobutyric acid receptor subunit beta-2213125
Aldehyde oxidase0101
Solute carrier family 22 member 60204
Solute carrier family 22 member 10507
Multidrug and toxin extrusion protein 20101
Solute carrier family 22 member 80206
GABA theta subunit213024
Multidrug and toxin extrusion protein 10404
Gamma-aminobutyric acid receptor subunit epsilon213024
Histamine H4 receptor0325
Solute carrier family 22 member 110104
Solute carrier family 22 member 20506
Solute carrier family 22 member 40101
Solute carrier family 22 member 80202
ATP-dependent phosphofructokinase9009
Chain A, HADH2 protein110011
Chain B, HADH2 protein110011
NFKB1 protein, partial4004
Thrombopoietin3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)9009
nonstructural protein 18008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a120012
serine/threonine-protein kinase mTOR isoform 12002
Solute carrier family 22 member 30203
Solute carrier family 22 member 30101
Sex hormone-binding globulin0022
Corticosteroid-binding globulin0303
Mineralocorticoid receptor 0224
Androgen receptor0404
C-8 sterol isomerase0101
Solute carrier organic anion transporter family member 1A10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sigma non-opioid intracellular receptor 10404
endonuclease IV3003
dopamine D1 receptor4004
GLS protein4004
regulator of G-protein signaling 48008
peripheral myelin protein 22 isoform 15005
atrial natriuretic peptide receptor 1 precursor5005
flap endonuclease 15005
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 436006
Alkaline phosphatase, germ cell type0101
G protein-coupled receptor GPR350011
G-protein coupled receptor 350011
G-protein coupled receptor 350011
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
Smad33003
cytochrome P450 2C9 precursor4004
Bile salt export pump0303
Myeloperoxidase0101
Dihydrofolate reductase0303
5-hydroxytryptamine receptor 60101
Chain A, Cruzipain5005
glucocerebrosidase2002
potassium voltage-gated channel subfamily H member 2 isoform d100010
DNA polymerase beta3003
DNA polymerase iota isoform a (long)6006
15-lipoxygenase, partial6006
nuclear factor NF-kappa-B p105 subunit isoform 11001
Acetylcholinesterase0101
Acetylcholinesterase0101
prostaglandin E2 receptor EP2 subtype1001
Solute carrier organic anion transporter family member 1A50001
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE9009
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Genome polyprotein 0213
chaperonin-containing TCP-1 beta subunit homolog1001
thioredoxin glutathione reductase5005
hypothetical protein, conserved2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a5005
eyes absent homolog 2 isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
histone acetyltransferase KAT2A isoform 18008
relaxin receptor 1 isoform 12002
Flavin reductase (NADPH)0011
large T antigen0101
Albumin0022
Luciferin 4-monooxygenase0112
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Tyrosine-protein phosphatase non-receptor type 10101
Nuclear factor NF-kappa-B p105 subunit0001
Tyrosine-protein phosphatase 10101
10 kDa heat shock protein, mitochondrial0101
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Vesicular glutamate transporter 30101
Nuclear receptor subfamily 1 group I member 20044
Nuclear receptor subfamily 1 group I member 20033
PPM1D protein100010
Caspase-71001
caspase-31001
Rap guanine nucleotide exchange factor 32002
Mitogen-activated protein kinase 140101
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit epsilon0202
Gamma-aminobutyric acid receptor subunit alpha-60213
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit theta0202
Disintegrin and metalloproteinase domain-containing protein 173003
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0022
D(1A) dopamine receptor3003
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
Histone deacetylase 30303
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40202
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10303
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10202
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70202
Histone deacetylase 20303
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0202
Histone deacetylase 80202
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60202
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Histone deacetylase 50202
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
apical membrane antigen 1, AMA11001
transforming acidic coiled-coil-containing protein 30001
Carbonic anhydrase 120002
Carbonic anhydrase 10305
Carbonic anhydrase 20317
Plasma kallikrein0002
Carbonic anhydrase 30002
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40204
Carbonic anhydrase 60002
Adenosine receptor A10103
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0103
Histamine H1 receptor0415
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0002
Histamine H1 receptor0438
Glutamate receptor ionotropic, NMDA 1 0002
Carbonic anhydrase0305
Carbonic anhydrase 70002
Carbonic anhydrase0003
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0002
Glutamate receptor ionotropic, NMDA 2B0002
Glutamate receptor ionotropic, NMDA 2C0002
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90002
Carbonic anhydrase 0003
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0003
Carbonic anhydrase0003
Glutamate receptor ionotropic, NMDA 2D0002
Carbonic anhydrase 0003
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0002
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 150204
Carbonic anhydrase 130001
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Glutamate receptor ionotropic, NMDA 3A0002
Carbonic anhydrase 140002
Carbonic anhydrase 5B, mitochondrial0002
Histamine H3 receptor0123
Spike glycoprotein0112
Replicase polyprotein 1ab0112
Transmembrane protease serine 20112
Procathepsin L0112
Alpha-2A adrenergic receptor0303
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0314
Replicase polyprotein 1ab0325
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-1D adrenergic receptor0202
Sigma intracellular receptor 20101
Cyclic GMP-AMP synthase0101
Angiotensin-converting enzyme 2 0112
Toll-like receptor 90101
Toll-like receptor 70101
Chain A, 2-oxoglutarate Oxygenase7007
tyrosine-protein kinase Yes1001
streptokinase A precursor0011
lethal factor (plasmid)6006
Prostaglandin E synthase0101
Prostaglandin G/H synthase 10202
Estrogen receptor0011
Polyunsaturated fatty acid 5-lipoxygenase0101
Polyunsaturated fatty acid 5-lipoxygenase0205
Arachidonate 5-lipoxygenase-activating protein0101
Prostaglandin G/H synthase 20303
Leukotriene C4 synthase0101
Macrophage-expressed gene 1 protein0101
Estrogen receptor beta0011
Leukotriene C4 synthase0001
Prostaglandin E synthase 20101
Leukotriene B4 receptor 10303
Leukotriene B4 receptor 20101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Phospholipase A-2-activating protein0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Glutathione reductase, mitochondrial0202
Cationic amino acid transporter 30101
huntingtin isoform 23003
Tyrosine-protein kinase ABL10314
Proto-oncogene tyrosine-protein kinase Src0303
Vascular endothelial growth factor receptor 20202
Calmodulin-domain protein kinase 10101
Glutaminyl-peptide cyclotransferase0101
Dihydrofolate reductase0405
Dipeptidyl peptidase 40101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
ClpP1001
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX122002
importin subunit beta-1 isoform 11001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0202
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Protein-arginine deiminase type-40202
Broad substrate specificity ATP-binding cassette transporter ABCG20102
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Nuclear receptor corepressor 20101
Prostaglandin G/H synthase 1 0101
Hormone-sensitive lipase0101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Caspase-10101
Prostaglandin G/H synthase 2 0102
Aldo-keto reductase family 1 member C30101
Caspase-30101
Caspase-40101
Caspase-50101
Aldo-keto reductase family 1 member C2 0101
Caspase-90101
Prostaglandin G/H synthase 20101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 1 0102
TSHR protein1001
PINK11001
Parkin2002
pyruvate kinase4004
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
cytochrome P450 2D6 isoform 13003
NPC intracellular cholesterol transporter 1 precursor4004
glucose-6-phosphate 1-dehydrogenase isoform b0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A4004
pyruvate kinase PKM isoform b2002
Aurora kinase A0101
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
3-phosphoinositide-dependent protein kinase 10101
Tyrosine-protein kinase JAK20101
Epidermal growth factor receptor0101
Tyrosine-protein kinase Lyn0101
Ornithine decarboxylase2002
Platelet-derived growth factor receptor beta0101
Mast/stem cell growth factor receptor Kit0101
Fibroblast growth factor receptor 10101
Serine/threonine-protein kinase B-raf0101
Protein kinase C alpha type0213
Mitogen-activated protein kinase 10101
RAC-alpha serine/threonine-protein kinase0101
Receptor-type tyrosine-protein kinase FLT30101
Alpha-synuclein1203
Signal transducer and activator of transcription 30202
Mitogen-activated protein kinase 80101
Glycogen synthase kinase-3 beta0101
D(1A) dopamine receptor1001
Angiopoietin-1 receptor0101
Anoctamin-10202
Rap guanine nucleotide exchange factor 41001
Aldo-keto reductase family 1 member B10102
Endothelin receptor type B2002
Endothelin-1 receptor2002
Pyruvate-flavodoxin oxidoreductase0101
Sodium/iodide cotransporter0101
Hematopoietic prostaglandin D synthase0202
Adenosine receptor A2a0202
30S ribosomal protein S60202
30S ribosomal protein S70202
50S ribosomal protein L150202
50S ribosomal protein L100202
50S ribosomal protein L110202
50S ribosomal protein L7/L120202
50S ribosomal protein L190202
50S ribosomal protein L10202
50S ribosomal protein L200202
50S ribosomal protein L270202
50S ribosomal protein L280202
50S ribosomal protein L290202
50S ribosomal protein L310202
50S ribosomal protein L31 type B0202
50S ribosomal protein L320202
50S ribosomal protein L330202
50S ribosomal protein L340202
50S ribosomal protein L350202
50S ribosomal protein L360202
30S ribosomal protein S100202
30S ribosomal protein S110202
30S ribosomal protein S120202
30S ribosomal protein S130202
30S ribosomal protein S160202
30S ribosomal protein S180202
30S ribosomal protein S190202
30S ribosomal protein S200202
30S ribosomal protein S20202
30S ribosomal protein S30202
30S ribosomal protein S40202
30S ribosomal protein S50202
30S ribosomal protein S80202
30S ribosomal protein S90202
50S ribosomal protein L130202
50S ribosomal protein L140202
50S ribosomal protein L160202
50S ribosomal protein L230202
30S ribosomal protein S150202
50S ribosomal protein L170202
50S ribosomal protein L210202
50S ribosomal protein L300202
50S ribosomal protein L60202
30S ribosomal protein S140202
30S ribosomal protein S170202
30S ribosomal protein S10202
50S ribosomal protein L180202
50S ribosomal protein L20202
50S ribosomal protein L30202
50S ribosomal protein L240202
50S ribosomal protein L40202
50S ribosomal protein L220202
50S ribosomal protein L50202
30S ribosomal protein S210202
50S ribosomal protein L250202
50S ribosomal protein L36 20202
Tyrosyl-DNA phosphodiesterase 10101
Albumin0011
Aldo-keto reductase family 1 member B10101
Neutrophil elastase0101
Complement C1s subcomponent0101
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0202
Nitric oxide synthase, inducible0101
Nitric oxide synthase, inducible0101
Collagenase 30202
Nitric oxide synthase, inducible0101
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b0011
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Androgen receptor0202
Glutamine synthetase0011
Nociceptin receptor0011
Estrogen receptor beta0202
heat shock protein HSP 90-alpha isoform 20102
heat shock protein 90, putative0001
galactokinase1001
5-hydroxytryptamine receptor 40202
Angiotensin-converting enzyme0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Sodium-dependent serotonin transporter0202
5-hydroxytryptamine receptor 2B0202
Sodium-dependent dopamine transporter 0202
Nuclear receptor subfamily 3 group C member 3 0202
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0101
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Neutral amino acid transporter A0101
Cholinesterase0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-K receptor0202
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-P receptor0101
Substance-K receptor0101
D(2) dopamine receptor0011
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Mas-related G-protein coupled receptor member X20011
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0224
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Solute carrier organic anion transporter family member 1B10101
Cytochrome P450 14alpha-demethylase0011
Sterol 14-alpha demethylase0101
Carnitine O-palmitoyltransferase 1, muscle isoform0101
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
Tetracycline resistance protein, class B0001
72 kDa type IV collagenase0101
Stromelysin-10101
Multidrug transporter MdfA0101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Cannabinoid receptor 10101
Integrase 0101
P2Y purinoceptor 120101
Serine/threonine-protein kinase D30011
Protein kinase C gamma type0112
Protein kinase C beta type0112
Beta-1 adrenergic receptor0101
Protein kinase C eta type0011
Protein kinase C iota type0011
Protein kinase C epsilon type0112
Protein kinase C theta type0011
Protein kinase C zeta type0011
Protein kinase C delta type0112
Serine/threonine-protein kinase D10011
Ras guanyl-releasing protein 30011
Chain A, Methionine aminopeptidase0101
BRCA11001
P531001
Methionine aminopeptidase 20101
Methionine aminopeptidase 10112
Reverse transcriptase/RNaseH 0101
Mu-type opioid receptor0112
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
MSH0001
Transient receptor potential cation channel subfamily A member 10101
NACHT, LRR and PYD domains-containing protein 3 0101
Transient receptor potential cation channel subfamily V member 20101
procathepsin L isoform 1 preproprotein0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Monocarboxylate transporter 100001
Taste receptor type 2 member 140001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]