triazoles has been researched along with phenobarbital in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (47.27) | 18.7374 |
| 1990's | 9 (16.36) | 18.2507 |
| 2000's | 8 (14.55) | 29.6817 |
| 2010's | 8 (14.55) | 24.3611 |
| 2020's | 4 (7.27) | 2.80 |
| Authors | Studies |
|---|---|
| Chance, B; Oshino, N | 1 |
| Bhat, KS; Padmanaban, G | 1 |
| Butler, WH; Magos, L; Snowden, R | 1 |
| Bhat, KS; Padmanaban, G; Sardana, MK | 1 |
| Haas, HL; Wolf, P | 1 |
| Bend, JR; Knickle, LC | 2 |
| Ashton, D; Willems, R | 1 |
| Bend, JR; Woodcroft, KJ | 1 |
| Catto, L; Jones, RB; Leonard, T; Poole, A; Pritchard, D | 1 |
| Matsubara, T; Touchi, A; Yamada, N | 1 |
| Costa, AK; Ortiz de Montellano, PR | 1 |
| Matsubara, T; Nishiyama, S; Touchi, A; Yamada, N | 1 |
| Baron, J; Tephly, TR | 2 |
| Carter, EA; Isselbacher, KJ | 1 |
| Castro, JA; D'Acosta, N; de Castro, CR; de Fenos, OM; de Ferreyra, EC; Díaz Gòmez, MI | 1 |
| Momose, S; Takagaki, E; Tanayama, S | 1 |
| Nichol, AW | 1 |
| Johnson, EA; Stenger, RJ | 1 |
| Khan, M; Knapp, M; Reese, WN; Roach, MK | 1 |
| Imai, Y; Siekevitz, P | 1 |
| Kato, R | 1 |
| DeCarli, LM; Lieber, CS | 1 |
| Bacchin, P; Hutterer, F; Raisfeld, IH; Schaffner, F | 1 |
| Baron, J; Hasegawa, E; Tephly, TR | 1 |
| Israels, LG; Levitt, M; Schacter, BA; Zipursky, A | 1 |
| Horiuchi, M; Inoue, Y; Yamamoto, K; Yoshimura, K | 1 |
| Padmanaban, G; Ravishankar, H | 1 |
| Berry, MN; Fanning, DC; Grivell, AR; Wallace, PG | 1 |
| Bend, JR; Grimm, SW; Halpert, JR | 1 |
| Bend, JR; Knickle, LC; Philpot, RM | 1 |
| Delaforge, M; Le Campion, L; Noel, JP; Ouazzani, J | 1 |
| Greenfield, LJ; Macdonald, RL; Neelands, TR; Turner, RS; Zhang, J | 1 |
| Carlile, DJ; Hakooz, N; Houston, JB | 1 |
| Abbott, FS; Chang, TK; Chen, J; Tong, V | 1 |
| Hu, YZ; Yao, TW | 1 |
| Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Hazelton, GA; Juberg, DR; Mudra, DR; Parkinson, A | 1 |
| Diani-Moore, S; Labitzke, E; Papachristou, F; Rifkind, AB | 1 |
| Currie, RA; Milburn, G; Moggs, JG; Pastoor, T; Peffer, RC; Rusyn, I; Waechter, F; Wright, J | 1 |
| Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH | 1 |
| Hester, SD; Moore, T; Nesnow, S; Ren, H; Ward, W | 1 |
| Abbott, FS; Chang, TK; Surendradoss, J | 1 |
| Inoue, K; Irie, K; Kodama, Y; Matsuo, S; Nishikawa, A; Ozawa, S; Takahashi, M; Tamura, K; Yoshida, M | 1 |
| Currie, RA; Goetz, AK; Goodman, JI; Omiecinski, CJ; Peffer, RC | 1 |
| Bai, XY; Du, GH; Hao, LH; Huang, ZL; Liu, R; Sun, ZM; Wu, S; Zhang, WK; Zhang, XQ; Zhang, YH | 1 |
| Haider, W; Heise, T; Knebel, C; Kneuer, C; Marx-Stoelting, P; Niemann, L; Pfeil, R; Rieke, S; Schmidt, F | 1 |
| Augustijns, P; Brouwers, J; Hens, B; Kourentas, A; Reppas, C; Symillides, M; Vertzoni, M | 1 |
| Braeuning, A; Ganzenberg, K; Hammer, H; Knebel, C; Marx-Stoelting, P; Pötz, O; Rieke, S; Schmidt, F; Schwarz, M | 1 |
| Rademacher, J; Welte, T | 1 |
| Chatham, LR; Fegert, I; Goettel, M; Haines, C; Honarvar, N; Lake, BG; Vardy, A | 1 |
| Drabik, M; Florek-Łuszczki, M; Głuszak, M; Jankiewicz, M; Kozińska, J; Plech, T; Plewa, Z; Wróblewska-Łuczka, P; Łuszczki, JJ | 1 |
| García-Peñas, JJ; Gil Nagel-Rein, A; Sánchez-Carpintero, R; Villanueva-Haba, V | 1 |
| Alves, G; Falcão, A; Fortuna, A; Meirinho, S; Rodrigues, M | 1 |
2 review(s) available for triazoles and phenobarbital
| Article | Year |
|---|---|
[New antibiotics - standstill or progress].
Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Infections; Ceftaroline; Ceftazidime; Cephalosporins; Clinical Trials as Topic; Drug Approval; Drug Combinations; Drug Resistance, Multiple, Bacterial; Ephedrine; Humans; Macrolides; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Penicillanic Acid; Phenobarbital; Staphylococcal Infections; Tazobactam; Theophylline; Triazoles | 2017 |
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain.
Topics: Anticonvulsants; Cannabidiol; Clobazam; Clonazepam; Diazepam; Dioxolanes; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Lennox Gastaut Syndrome; Phenobarbital; Practice Guidelines as Topic; Pyrrolidinones; Spain; Triazoles; Valproic Acid | 2021 |
53 other study(ies) available for triazoles and phenobarbital
| Article | Year |
|---|---|
Properties of glutathione release observed during reduction of organic hydroperoxide, demethylation of aminopyrine and oxidation of some substances in perfused rat liver, and their implications for the physiological function of catalase.
Topics: Aminopyrine; Animals; Benzylamines; Catalase; Cell Separation; Glutathione; Glutathione Peroxidase; Glycolates; Liver; Male; Mitochondria, Liver; NADP; Nucleotides; Oxidation-Reduction; Perfusion; Peroxides; Phenobarbital; Rats; Triazoles; Uric Acid | 1977 |
Cytochrome P-450 synthesis in vivo and in a cell-free system from rat liver.
Topics: Animals; Cell-Free System; Cytochrome P-450 Enzyme System; Dactinomycin; Immunologic Techniques; Liver; Male; Phenobarbital; Rats; Triazoles | 1978 |
The hepatotoxicity of 3-amino-1,2,4-triazole and carbon disulphide in phenobarbitone-treated starved rats.
Topics: Alanine Transaminase; Amitrole; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Liver; Male; Phenobarbital; Rats; Starvation; Time Factors; Triazoles | 1978 |
Role of haem in the synthesis and assembly of cytochrome P-450.
Topics: Aminolevulinic Acid; Animals; Apoenzymes; Binding Sites; Cytochrome P-450 Enzyme System; Heme; Hemin; Male; Microsomes, Liver; Phenobarbital; Rats; Triazoles | 1977 |
Effects of diazepines and barbiturates on hippocampal recurrent inhibition.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Diazepam; Electric Stimulation; Evoked Potentials; Hippocampus; Neural Inhibition; Pentobarbital; Phenobarbital; Rats; Substantia Nigra; Thiamylal; Time Factors; Triazoles | 1977 |
Dose-dependent, mechanism-based inactivation of cytochrome P450 monooxygenases in vivo by 1-aminobenzotriazole in liver, lung, and kidney of untreated, phenobarbital-treated, and beta-naphthoflavone-treated guinea pigs.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Guinea Pigs; Isoenzymes; Kidney; Liver; Lung; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Triazoles | 1992 |
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Pentobarbital; Phenobarbital; Triazoles | 1992 |
N-aralkylated derivatives of 1-aminobenzotriazole as isozyme-selective, mechanism-based inhibitors of guinea pig hepatic cytochrome P-450 dependent monooxygenase activity.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Guinea Pigs; Isoenzymes; Kinetics; Liver; Male; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Triazoles | 1990 |
In vitro accumulation of thyroid hormones by cultured rat hepatocytes and the biliary excretion of iodothyronines in rats treated with a novel histamine H2-receptor antagonist.
Topics: Animals; Bile; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Histamine H2 Antagonists; Liver; Male; Phenobarbital; Pyrimidinones; Rats; Rats, Inbred Strains; Temperature; Thyroid Hormones; Thyroxine; Triazoles; Triiodothyronine | 1989 |
Effect of change of hepatic drug-metabolizing activity on plasma concentrations of major metabolites of the new sleep inducer 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Enzyme Induction; Hypnotics and Sedatives; Liver; Male; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Triazoles | 1987 |
Dissociation of cytochrome P-450 inactivation and induction.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA, Messenger; Triazoles | 1986 |
[Effect of a new sleep inducer, 1H-1,2,4-triazolyl benzophenone derivative 450191-S on rat liver drug-metabolizing enzyme system].
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Drug Interactions; Hypnotics and Sedatives; Liver; Male; Microsomes, Liver; Nitrazepam; Pentobarbital; Phenobarbital; Rats; Rats, Inbred Strains; Triazoles | 1985 |
The role of heme synthesis during the induction of hepatic microsomal cytochrome P-450 and drug metabolism produced by benzpyrene.
Topics: Acyltransferases; Amino Acids; Animals; Azo Compounds; Benzopyrenes; Carbon Isotopes; Cytochromes; Depression, Chemical; Enzyme Induction; Glycine; Heme; Levulinic Acids; Liver; Male; Microsomes; NADP; Oxidoreductases; Phenobarbital; Rats; Stimulation, Chemical; Time Factors; Transferases; Triazoles | 1969 |
Effect of 3-amino-1,2,4-triazole on the stimulation of hepatic microsomal heme synthesis and induction of hepatic microsomal oxidases produced by phenobarbital.
Topics: Animals; Azo Compounds; Carbon Isotopes; Cytochromes; Enzyme Induction; Heme; Hydro-Lyases; Iron Isotopes; Levulinic Acids; Male; Microsomes, Liver; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rats; Time Factors; Triazoles | 1969 |
The role of microsomes in the hepatic metabolism of ethanol.
Topics: Acetates; Adenine Nucleotides; Aerobiosis; Amino Alcohols; Anaerobiosis; Animals; Azides; Bile Acids and Salts; Carbon Monoxide; Catalase; Cell Fractionation; Chlorides; Chloromercuribenzoates; Copper; Cyanides; Diet; Dimethyl Sulfoxide; Edetic Acid; Ethanol; Female; Hot Temperature; Hydrogen Peroxide; Iron; Liver; Mercury; Microsomes, Liver; NAD; NADP; Oxidoreductases; Phenobarbital; Pyrazoles; Rats; Sulfides; Triazoles | 1971 |
Role of cytochrome P-450 in carbon tetrachloride activation and CCl 4-induced necrosis. Effect of inhibitors of heme synthesis. I. 3-Amino-1,2,4 triazole.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activation; Female; Heme; Lipid Metabolism; Liver; Male; Microsomes, Liver; Necrosis; Organ Size; Phenobarbital; Triazoles | 1973 |
Metabolism of 8-chloro-6-phenyl-4H-s-triazole(4,3-a)(1,4)benzodiazepine (D-40TA), a new central depressant. 3. Metabolism and tolerance studies in rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzazepines; Brain; Carbon Radioisotopes; Chlordiazepoxide; Drug Tolerance; Heart; Intestine, Small; Kidney; Lung; Male; Muscle Relaxants, Central; Myocardium; Nitrazepam; Phenobarbital; Rats; Spinal Cord; Time Factors; Triazoles; Zoxazolamine | 1974 |
The formation of biliverdin by chicken macrophages in tissue culture. Observations on the effect of inhibitors.
Topics: Acetanilides; Animals; Ascorbic Acid; Azides; Bile Pigments; Carbon Monoxide; Chickens; Chloramphenicol; Culture Techniques; Cyanides; Cycloheximide; Dactinomycin; Erythrocytes; Ethylmaleimide; Female; Heme; Hydrogen Peroxide; Macrophages; Metabolism; Microscopy, Phase-Contrast; Mitomycins; Phagocytosis; Phenobarbital; Proadifen; Quinacrine; Spectrophotometry; Spectrum Analysis; Stimulation, Chemical; Triazoles | 1970 |
Modifying effect of 3-amino-1,2,4-triazole on phenobarbital-induced changes in rat liver.
Topics: Amitrole; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochromes; Drug Antagonism; Endoplasmic Reticulum; Enzyme Induction; Herbicides; Liver; Liver Diseases; Male; Microscopy, Electron; Microsomes, Liver; Necrosis; Paralysis; Phenobarbital; Rats; Triazoles; Zoxazolamine | 1972 |
Ethanol metabolism in vivo and the role of hepatic microsomal ethanol oxidation.
Topics: Alcohol Oxidoreductases; Animals; Benzopyrenes; Chromatography, Gas; Ethanol; Ethylamines; Injections, Intraperitoneal; Male; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Triazoles | 1972 |
A comparison of some properties of microsomal cytochrome P-450 from normal, methylcholanthrene-, and phenobarbital-treated rats.
Topics: 1-Propanol; Amines; Animals; Chemical Phenomena; Chemistry; Chlorides; Cycloheximide; Cytochromes; Fasting; Fatty Alcohols; Heme; Hydrogen-Ion Concentration; Kinetics; Male; Mathematics; Mercury; Methylcholanthrene; Microsomes, Liver; Nitriles; Oxidation-Reduction; Phenobarbital; Potassium; Protein Biosynthesis; Rats; Spectrophotometry; Sulfites; Thiocyanates; Triazoles | 1971 |
Effect of administration of 3-aminotriazole on the activity of microsomal drug-metabolizing enzyme systems of rat liver.
Topics: Aminopyrine; Aniline Compounds; Animals; Blood Proteins; Brain; Brain Chemistry; Cytochromes; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Nitrobenzenes; Pentobarbital; Phenobarbital; Pigments, Biological; Rats; Spectrophotometry; Triazoles; Zoxazolamine | 1967 |
Effect of drug administration on the activity of the hepatic microsomal ethanol oxidizing system.
Topics: Alcohol Oxidoreductases; Animals; Catalase; Ethanol; Female; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxidation-Reduction; Phenobarbital; Proteins; Rats; Toluene; Triazoles | 1970 |
The effect of 3-amino-1,2,4-triazole on the phenobarbtial-induced formation of hepatic microsomal membranes.
Topics: Amino Acids; Aniline Compounds; Animals; Benzopyrenes; Cytochromes; Endoplasmic Reticulum; Liver Glycogen; Male; Membranes; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; Perfusion; Phenobarbital; Phospholipids; Proteins; Rats; Triazoles | 1970 |
Effect of drugs on heme synthesis in the liver.
Topics: Acyltransferases; Animals; Benzopyrenes; Cytochromes; Depression, Chemical; Glycine; Heme; Lead; Levulinic Acids; Liver; Lyases; Microsomes, Liver; Mitochondria; Oxidoreductases; Phenobarbital; Pyridines; Rats; Stimulation, Chemical; Succinates; Triazoles | 1971 |
The nonerythropoietic component of early bilirubin.
Topics: Amides; Amino Acids; Animals; Bile Ducts; Biliary Fistula; Bilirubin; Carbon Isotopes; Catalase; Cycloheximide; Cytochromes; Erythropoiesis; Glycine; Heme; Infusions, Parenteral; Kidney; Lead Poisoning; Levulinic Acids; Male; Nephrectomy; Phenobarbital; Porphyrins; Protein Biosynthesis; Rats; Triazoles | 1968 |
[Pharmacological studies on drug dependence. (III): Intravenous self-administration of some CNS-affecting drugs and a new sleep-inducer, 1H-1, 2, 4-triazolyl benzophenone derivative (450191-S), in rats].
Topics: Animals; Central Nervous System Agents; Cocaine; Diazepam; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Methamphetamine; Morphine Dependence; Pentazocine; Phenobarbital; Rats; Rats, Inbred Strains; Self Administration; Substance-Related Disorders; Triazoles | 1984 |
Effect of cobalt chloride and 3-amino-1,2,4-triazole on the induction of cytochrome P-450 synthesis by phenobarbitone in rat liver.
Topics: Amitrole; Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Triazoles | 1983 |
Ethanol oxidation by isolated hepatocytes from fed and starved rats and from rats exposed to ethanol, phenobarbitone or 3-amino-trizazole. No evidence for a physiological role of a microsomal ethanol oxidation system.
Topics: Amitrole; Animals; Electron Transport; Ethanol; In Vitro Techniques; Liver; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rotenone; Starvation; Triazoles | 1980 |
Selectivity and kinetics of inactivation of rabbit hepatic cytochromes P450 2B4 and 2B5 by N-aralkylated derivatives of 1-aminobenzotriazole.
Topics: Alkylation; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Isoenzymes; Kidney; Kinetics; Liver; Mice; Microsomes, Liver; Phenobarbital; Rabbits; Recombinant Proteins; Steroid Hydroxylases; Triazoles | 1995 |
Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Guinea Pigs; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Triazoles | 1994 |
N-aralkylated derivatives of 1-aminobenzotriazole are potent isozyme- and lung-selective mechanism-based inhibitors of guinea pig cytochrome P-450 in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Guinea Pigs; Isoenzymes; Liver; Lung; Male; Phenobarbital; Sensitivity and Specificity; Triazoles | 1994 |
Metabolism of 14C-labelled 5-nitro-1,2,4-triazol-3-one by rat liver microsomes--evidence for the participation of cytochrome P-450.
Topics: Animals; Carbon Radioisotopes; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Fungal Proteins; Glucocorticoids; Male; Methylcholanthrene; Microsomes, Liver; Nitro Compounds; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles | 1997 |
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells.
Topics: Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Diuretics; DNA Primers; Furosemide; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Lanthanum; Neurons; Patch-Clamp Techniques; Pentobarbital; Phenobarbital; Picrotoxin; Polymerase Chain Reaction; Pregnanediones; Pregnenolone; Pyridines; Receptors, GABA-A; RNA, Messenger; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem | 1998 |
Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity.
Topics: Animals; beta-Naphthoflavone; Cell Separation; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles | 1999 |
The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
Topics: Animals; Anticonvulsants; Biotransformation; Cytochrome P-450 Enzyme System; Dinoprost; Enzyme Inhibitors; F2-Isoprostanes; Gas Chromatography-Mass Spectrometry; Lipid Peroxides; Liver; Male; Oxidative Stress; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Triazoles; Valproic Acid | 2003 |
In vitro metabolism and inductive or inhibitive effect of DL111 on rat cytochrome P4501A enzyme.
Topics: Abortifacient Agents, Nonsteroidal; Animals; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Dexamethasone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Induction; Enzyme Inhibitors; Female; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles | 2004 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Kindling, Neurologic; Linear Models; Male; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Triazoles; Valproic Acid | 2005 |
The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Body Weight; Cell Enlargement; Cell Proliferation; Cytochrome P-450 CYP2B1; Cytochrome P450 Family 2; Cytochromes b5; Dose-Response Relationship, Drug; Enzyme Induction; Female; Fungicides, Industrial; Hepatocytes; Liver; Liver Neoplasms; Mice; Nitriles; Organ Size; Phenobarbital; Steroid Hydroxylases; Time Factors; Triazoles | 2006 |
Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole.
Topics: Animals; Arachidonic Acids; Aromatase Inhibitors; Benzimidazoles; Cell Line, Tumor; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Mice; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; RNA, Messenger; Triazoles | 2006 |
Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.
Topics: Administration, Oral; Animals; Antigens, Differentiation; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cytochrome P450 Family 2; Diet; Dose-Response Relationship, Drug; Enzyme Induction; Fatty Liver; Fungicides, Industrial; Gene Expression Regulation; Gene Silencing; Hepatocytes; Hypertrophy; Liver; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Phenobarbital; Proto-Oncogene Proteins c-mdm2; Receptors, Androgen; Species Specificity; Steroid Hydroxylases; Triazoles; Vacuoles | 2007 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Mice; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Triazoles; Valproic Acid | 2008 |
Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Fungicides, Industrial; Gene Expression; Gene Expression Profiling; Hybridization, Genetic; Liver; Male; Mice; Oligonucleotide Array Sequence Analysis; Organ Size; Phenobarbital; Transcription Factors; Transcription, Genetic; Triazoles | 2009 |
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
Topics: Animals; Cell Culture Techniques; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Hepatocytes; Male; Molecular Structure; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles; Valproic Acid | 2012 |
Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides.
Topics: Animals; Constitutive Androstane Receptor; Dose-Response Relationship, Drug; Enzyme Induction; Fluconazole; Fungicides, Industrial; Hepatomegaly; Liver; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Triazoles | 2013 |
Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Proliferation; Constitutive Androstane Receptor; Female; Fungicides, Industrial; Genes, Reporter; Hepatocytes; Hypnotics and Sedatives; Male; Mice; Neoplasms, Experimental; Organ Size; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Toxicogenetics; Triazoles; Weight Gain | 2014 |
WS0701: a novel sedative-hypnotic agent acting on the adenosine system.
Topics: Adenosine; Animals; Behavior, Animal; Decanoates; Frontal Lobe; Hypnotics and Sedatives; Hypothalamus; Male; Maze Learning; Mice; Phenobarbital; Picrotoxin; Pyrimidines; Rats; Rats, Sprague-Dawley; Sleep Stages; Time Factors; Triazoles | 2014 |
Hepatotoxic effects of (tri)azole fungicides in a broad dose range.
Topics: Animals; Chemical and Drug Induced Liver Injury; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Epoxy Compounds; Fungicides, Industrial; Gene Expression Regulation; Hepatocytes; Imidazoles; Male; Phenobarbital; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Triazoles | 2015 |
In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT.
Topics: Capsules; Duodenum; Fasting; Gastric Mucosa; Gastrointestinal Transit; Humans; Intestinal Absorption; Itraconazole; Phenobarbital; Solubility; Triazoles | 2016 |
Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Constitutive Androstane Receptor; Dose-Response Relationship, Drug; Fungicides, Industrial; Gene Expression Regulation; Hepatocytes; Humans; Imidazoles; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Triazoles; Up-Regulation | 2017 |
Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats.
Topics: Animals; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; DNA; Dose-Response Relationship, Drug; Gene Knockout Techniques; Hepatocytes; Male; Mice, Knockout; Phenobarbital; Quinazolinones; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Triazoles | 2020 |
Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Male; Mice; Muscle Strength; Phenobarbital; Phenytoin; Rotarod Performance Test; Seizures; Thiones; Triazoles; Valproic Acid | 2021 |
Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model.
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme Inducers; Dioxolanes; Drug Interactions; Humans; Nitriles; Phenobarbital; Pyridones; Rifampin; Triazoles | 2022 |