Pythiosis

A granulomatous disease caused by the aquatic organism PYTHIUM insidiosum and occurring primarily in horses, cattle, dogs, cats, fishes, and rarely in humans. It is classified into three forms: ocular, cutaneous, and arterial.

Synonym
Pythiosis
Pythiosis Insidiosi
Pythium insidiosum Infection

Excerpt	Reference
"Medical therapy for pythiosis is hampered by a lack of efficacious drugs."	( Birkenheuer, A; Davidson, G; Grooters, A; Hummel, J; Jennings, S; Nicklas, J, 2011)
"Human pythiosis is an emerging and life-threatening infectious disease caused by Pythium insidiosum."	( Sirisanthana, V; Sudjaritruk, T, 2011)
"Pythiosis is a life-threatening disease caused by the oomycete Pythium insidiosum."	( Alves, SH; Bach, BC; Casali, EA; de Lima Pereira, P; Hecktheuer, PA; Jaques, JA; Leal, DB; Ruchel, JB; Santurio, JM; Schlemmer, KB; Souza, Vdo C; Zanette, RA, 2013)
"Pythiosis is a severe and life-threatening disease that affects humans and various animal species."	( Alves, SH; Jesus, FPK; Kommers, GD; Ledur, PC; Loreto, ÉS; Santurio, JM; Silva, TM; Tondolo, JSM, 2017)
"Pythiosis is a life-threatening disease caused by the fungus-like microorganism Pythium insidiosum that can lead to death if not treated."	( Alves, SH; Jesus, FPK; Ledur, PC; Loreto, ÉS; Santurio, JM; Tondolo, JSM; Verdi, CM, 2018)
"Vascular pythiosis is a life-threatening infection caused by the oomycete Pythium insidiosum."	( Chindamporn, A; Chitasombat, MN; Krajaejun, T; Larbcharoensub, N, 2018)
"Ocular pythiosis is the second most common form of human pythiosis, and the rates of evisceration/enucleation in Thailand are 55-79%."	( Chindamporn, A; Chuleerarux, N; Manothummetha, K; Permpalung, N; Plongla, R; Ratanawongphaibul, K; Torvorapanit, P; Worasilchai, N, 2019)
"Pythiosis is an emerging infectious disease caused by the aquatic oomycete Pythium insidiosum, a fungal-like organism."	( Chindamporn, A; Permpalung, N; Worasilchai, N, 2020)
"Pythiosis is a rapidly progressing disease that can be lethal to affected individuals due to resistance to available therapeutic protocols."	( Albano, APN; Botton, SA; Braga, CQ; Brasil, CL; Franz, HC; Panagio, LA; Pereira, DIB; Pötter, L; Reis, GF; Sallis, ESV; Valente, JSS; Zamboni, R; Zambrano, CG, 2020)
"Pythiosis is reported in tropical and subtropical climates, affecting dogs and rarely cats."	( Cridge, H; Hughes, SM; Langston, VC; Mackin, AJ, 2020)
"Gastrointestinal pythiosis is a severe, progressive and often a fatal disease, which is caused by the aquatic pathogen Pythium insidiosum."	( Chansiripornchai, P; Kesdangsakonwut, S; Sukanan, P; Suparp, B; Yongsiri, S, 2022)
"Pythiosis is a serious disease caused by the aquatic oomycete Pythium insidiosum that mainly affects mammals."	( Bermann, CDS; Botton, SA; Braga, CQ; Bruhn, FRP; Ianiski, LB; Pereira, DIB; Silveira, JS, 2023)

Excerpt	Reference
"Pythium insidiosum infections have been widely studied in an attempt to develop an effective therapeutic protocol for the treatment of human and animal pythiosis."	( Botton, SA; Denardi, LB; Ianiski, LB; Pereira, DIB; Sangioni, LA; Santurio, JM; Soares, MP; Stibbe, PC; Valente, JSS; Weiblen, C, 2021)

Excerpt	Reference
"Despite aggressive treatment, vascular pythiosis has a mortality rate of 40%."	( Chindamporn, A; Chongsathidkiet, P; Finkelman, M; Leelahavanichkul, A; Mendoza, AL; Palaga, T; Permpalung, N; Reantragoon, R; Sutcharitchan, P; Worasilchai, N, 2018)
"Potassium iodide therapy may treat rhinofacial pythiosis in sheep."	( Boabaid, FM; Campos, CG; Colodel, EM; Dutra, V; Nakazato, L; Pereira, AHB; Pescador, CA; Riet-Correa, F; Ubiali, DG, 2022)
"Medical treatment for pythiosis was successful with a combination of oral terbinafine and prednisolone."	( Chansiripornchai, P; Kesdangsakonwut, S; Sukanan, P; Suparp, B; Yongsiri, S, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	49 (72.06)	28.8240
2020's	19 (27.94)	9.53

Drug	Relationship Strength	Studies
adenine	low	1
dimethyl sulfoxide	low	1
phosphorylcholine	low	3
sulfuric acid	low	1
menthol	low	1
danthron	low	1
fluconazole	low	1
miltefosine	low	3
ibuprofen	low	1
potassium iodide	low	1
hydrocortisone acetate	low	1
prednisone	low	2
alanine	low	2
9,10-anthraquinone	low	1
thymol	low	1
carvacrol	low	2
pyrrolnitrin	low	1
diphenyldiselenide	low	1
alpha-terpineol	low	1
silver	low	1
loceryl	low	1
itraconazole	low	13
triazoles	low	4
enrofloxacin	low	2
voriconazole	low	2
oxazolidin-2-one	low	1
clarithromycin	low	4
atropine	low	1
deferasirox	low	3
epiglucan	low	5
linezolid	low	6
valnemulin	low	1
zithromax	low	13
u 100480	low	1
l 743,872	low	2
micafungin	low	1
tiamulin	low	1
curcumin	low	1
terbinafine	low	13
amphotericin b	low	3
(3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid	low	1
retapamulin	low	1
amoxicillin-potassium clavulanate combination	low	1
mocetinostat	low	1
mefenoxam	low	2
tannins	low	1
tetracycline	low	1
minocycline	low	4
tigecycline	low	2
agar	low	1
eye	low	1

Protein Targets (570)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Cytochrome P450 2C9	0	9	0	10
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	1	0	0	1
thioredoxin reductase	2	0	0	2
USP1 protein, partial	7	0	0	7
TDP1 protein	14	0	0	14
vitamin D3 receptor isoform VDRA	7	0	0	7
importin subunit beta-1 isoform 1	6	0	0	6
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	4	0	0	4
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
geminin	12	0	0	12
DNA polymerase kappa isoform 1	3	0	0	3
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	2	0	2
Transthyretin	0	1	1	2
Fatty acid-binding protein, intestinal	0	2	1	3
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
RAR-related orphan receptor gamma	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
retinoid X nuclear receptor alpha	12	0	0	12
estrogen-related nuclear receptor alpha	15	0	0	15
pregnane X nuclear receptor	15	0	0	15
estrogen nuclear receptor alpha	20	0	0	20
Histone H2A.x	7	0	0	7
histone deacetylase 9 isoform 3	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
peripheral myelin protein 22	5	0	0	5
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Glutamate receptor 2	6	0	0	6
Amine oxidase [flavin-containing] A	0	7	0	7
Dual specificity protein phosphatase 1	0	1	0	1
M-phase inducer phosphatase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Dual specificity protein phosphatase 6	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	2	0	2
Histone-lysine N-methyltransferase EHMT1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
AR protein	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
glucocorticoid receptor [Homo sapiens]	13	0	0	13
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
heat shock protein beta-1	5	0	0	5
tumor susceptibility gene 101 protein	2	0	0	2
lamin isoform A-delta10	14	0	0	14
Bile salt export pump	0	12	0	12
Cyclin-dependent kinase 1	0	2	0	2
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	7	0	0	7
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Carbonic anhydrase 1	0	2	0	3
Carbonic anhydrase 2	0	2	0	3
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
phosphopantetheinyl transferase	4	0	0	4
GLI family zinc finger 3	13	0	0	13
Cellular tumor antigen p53	15	0	0	15
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Cruzipain	3	0	0	3
interleukin 8	4	0	0	4
GLS protein	4	0	0	4
farnesoid X nuclear receptor	9	0	0	9
peroxisome proliferator-activated receptor delta	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
tumor necrosis factor	1	0	0	1
Cytochrome P450 1A2	0	3	0	4
Cytochrome P450 3A4	0	9	0	10
Cytochrome P450 2D6	0	5	0	6
Cytochrome P450 2C19	0	5	0	6
Nuclear receptor ROR-gamma	5	0	0	5
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Aurora kinase B	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
cystic fibrosis transmembrane conductance regulator	0	2	0	2
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	9
5-hydroxytryptamine receptor 4	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	2	1	6
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	2	1	5
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	2	0	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	9	0	9
thyroid stimulating hormone receptor	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Acetylcholinesterase	0	3	0	3
Polyphenol oxidase 2	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	3	3
Acetylcholinesterase	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	0	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Cholinesterase	0	3	0	3
Secreted chorismate mutase	0	3	0	3
thyroid hormone receptor beta isoform 2	13	0	0	13
mitogen-activated protein kinase 1	4	0	0	4
streptokinase A precursor	0	0	4	4
ATP-dependent translocase ABCB1	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Luciferase	6	0	0	6
acetylcholinesterase	2	0	0	2
Nrf2	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
SMAD family member 2	4	0	0	4
ATAD5 protein, partial	2	0	0	2
SMAD family member 3	4	0	0	4
Microtubule-associated protein tau	3	0	0	3
alkaline phosphatase, intestinal	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
Smad3	1	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
PINK1	1	0	0	1
thyroid stimulating hormone receptor	3	0	0	3
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	4	0	0	4
EWS/FLI fusion protein	7	0	0	8
glucocerebrosidase	1	0	0	1
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
toll-like receptor 9	0	1	0	1
peroxisome proliferator activated receptor gamma	8	0	0	8
caspase-3	1	0	0	1
IDH1	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
TPA: protein transporter TIM10	0	1	0	1
aryl hydrocarbon receptor	4	0	0	4
activating transcription factor 6	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
lysosomal alpha-glucosidase preproprotein	1	0	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
transcriptional regulator ERG isoform 3	4	0	0	4
huntingtin isoform 2	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	6	0	0	6
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
cytochrome P450 3A4 isoform 1	3	0	0	3
muscleblind-like protein 1 isoform 1	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
hypothetical protein SA1422	0	1	0	1
lethal factor (plasmid)	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
Prostaglandin E synthase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Histone deacetylase 3	0	4	0	4
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Amyloid-beta precursor protein	0	1	0	2
Integrin beta-3	1	0	0	1
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Cholinesterase	0	2	0	2
Heme oxygenase 1	0	2	0	2
Integrin alpha-IIb	1	0	0	1
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
60 kDa chaperonin	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Microtubule-associated protein tau	0	1	0	2
60 kDa heat shock protein, mitochondrial	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	1	0	1
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Alpha-1B adrenergic receptor	0	2	0	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Heme oxygenase 2	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Amine oxidase [flavin-containing] B	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Prostaglandin G/H synthase 2	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-synuclein	1	2	1	4
Alpha-1A adrenergic receptor	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Caspase-7	1	0	0	1
Histone deacetylase 4	0	3	0	3
Beta-secretase 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Histone deacetylase 1	0	5	0	5
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thiosulfate sulfurtransferase	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Histone deacetylase 7	0	3	0	3
GABA theta subunit	3	0	0	3
Histone deacetylase 2	0	5	0	5
CREB-binding protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	3	0	3
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Histone deacetylase 8	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	3	0	3
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
Chain B, Retinoid X receptor, alpha	0	0	1	1
survival motor neuron protein isoform d	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
5-lipoxygenase	0	1	0	1
Sialidase-2	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
Fumarate hydratase	3	0	0	3
polyprotein	3	0	0	3
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4A	0	1	1	2
Lysine-specific demethylase 5A	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Gamma-butyrobetaine dioxygenase	0	1	1	2
nonstructural protein 1	2	0	0	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
G	8	0	0	8
cytochrome P450 2D6	5	0	0	5
unnamed protein product	0	1	0	1
chromobox protein homolog 1	3	0	0	3
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Chymotrypsinogen A	0	1	0	1
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	2	3
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	1	1	2
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
Inositol hexakisphosphate kinase 1	8	0	0	8
14-alpha sterol demethylase	0	0	2	2
cytochrome P450 2C9, partial	8	0	0	8
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
Corticosteroid-binding globulin	0	1	0	1
NFKB1 protein, partial	1	0	0	1
67.9K protein	2	0	0	2
arylsulfatase A	1	0	0	1
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Albumin	0	1	2	3
Albumin	0	1	0	1
Albumin	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Caspase-1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
GALC protein	1	0	0	1
Spike glycoprotein	6	0	0	6
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
30S ribosomal protein S6	0	3	1	4
30S ribosomal protein S7	0	3	1	4
50S ribosomal protein L15	0	3	1	4
Estrogen receptor	0	0	1	1
50S ribosomal protein L10	0	3	1	4
50S ribosomal protein L11	0	3	1	4
50S ribosomal protein L7/L12	0	3	1	4
50S ribosomal protein L19	0	3	1	4
50S ribosomal protein L1	0	3	1	4
50S ribosomal protein L20	0	3	1	4
50S ribosomal protein L27	0	3	1	4
50S ribosomal protein L28	0	3	1	4
50S ribosomal protein L29	0	3	1	4
50S ribosomal protein L31	0	3	1	4
50S ribosomal protein L31 type B	0	3	1	4
50S ribosomal protein L32	0	3	1	4
50S ribosomal protein L33	0	3	1	4
50S ribosomal protein L34	0	3	1	4
50S ribosomal protein L35	0	3	1	4
50S ribosomal protein L36	0	3	1	4
30S ribosomal protein S10	0	3	1	4
30S ribosomal protein S11	0	3	1	4
30S ribosomal protein S12	0	3	1	4
30S ribosomal protein S13	0	3	1	4
30S ribosomal protein S16	0	3	1	4
30S ribosomal protein S18	0	3	1	4
30S ribosomal protein S19	0	3	1	4
30S ribosomal protein S20	0	3	1	4
30S ribosomal protein S2	0	3	1	4
30S ribosomal protein S3	0	3	1	4
30S ribosomal protein S4	0	3	1	4
30S ribosomal protein S5	0	3	1	4
30S ribosomal protein S8	0	3	1	4
30S ribosomal protein S9	0	3	1	4
50S ribosomal protein L13	0	3	1	4
50S ribosomal protein L14	0	3	1	4
50S ribosomal protein L16	0	3	1	4
50S ribosomal protein L23	0	3	1	4
30S ribosomal protein S15	0	3	1	4
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
50S ribosomal protein L17	0	3	1	4
50S ribosomal protein L21	0	3	1	4
50S ribosomal protein L30	0	3	1	4
50S ribosomal protein L6	0	3	1	4
30S ribosomal protein S14	0	3	1	4
30S ribosomal protein S17	0	3	1	4
30S ribosomal protein S1	0	3	1	4
50S ribosomal protein L18	0	3	1	4
Amine oxidase [flavin-containing] B	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
50S ribosomal protein L2	0	3	1	4
50S ribosomal protein L3	0	3	1	4
50S ribosomal protein L24	0	3	1	4
50S ribosomal protein L4	0	3	1	4
50S ribosomal protein L22	0	3	1	4
50S ribosomal protein L5	0	3	1	4
30S ribosomal protein S21	0	3	1	4
50S ribosomal protein L25	0	3	1	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
50S ribosomal protein L36 2	0	3	1	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	1	1
Renin	0	1	0	1
Transient receptor potential cation channel subfamily M member 8	0	1	2	4
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Transient receptor potential cation channel subfamily M member 8	0	1	2	3
Platelet-activating factor receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Stromelysin-1	0	2	0	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Protein-arginine deiminase type-4	0	4	0	4
PPM1D protein	2	0	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Vpr	1	0	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 9	0	2	0	2
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain B, Odorant-binding Protein	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Heat sensitive channel TRPV3	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Cytochrome P450 2B6	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
glp-1 receptor, partial	1	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (68)

Protein Targets (570)

Pythiosis

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (68)

Drugs Studied (62)

Protein Targets (570)