Compounds > 17-dihydroexemestane
Page last updated: 2024-11-13

17-dihydroexemestane

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Cross-References

ID SourceID
PubMed CID25171222
CHEMBL ID3526952
SCHEMBL ID3808198
MeSH IDM0538358

Synonyms (12)

Synonym
SCHEMBL3808198
dhexe cpd
u35zno9djh ,
fce-25071
140461-66-1
17-dihydroexemestane
androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-
unii-u35zno9djh
CHEMBL3526952
NFDPYPMRHKQTDM-IMAGCOIZSA-N
Q27290625
(8r,9s,10r,13s,14s)-17-hydroxy-10,13-dimethyl-6-methylidene-8,9,11,12,14,15,16,17-octahydro-7h-cyclopenta[a]phenanthren-3-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytochrome P450 3A4Homo sapiens (human)Km98.66001.93005.90608.7000AID1216024
Cytochrome P450 2A6Homo sapiens (human)Km55.00000.74000.74000.7400AID1215991
Cytochrome P450 2B6Homo sapiens (human)Km177.00000.45000.45000.4500AID1215990
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (67)

Processvia Protein(s)Taxonomy
cellular response to organic cyclic compoundCytochrome P450 1A1Homo sapiens (human)
response to hypoxiaCytochrome P450 1A1Homo sapiens (human)
long-chain fatty acid metabolic processCytochrome P450 1A1Homo sapiens (human)
lipid hydroxylationCytochrome P450 1A1Homo sapiens (human)
fatty acid metabolic processCytochrome P450 1A1Homo sapiens (human)
steroid biosynthetic processCytochrome P450 1A1Homo sapiens (human)
porphyrin-containing compound metabolic processCytochrome P450 1A1Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 1A1Homo sapiens (human)
steroid metabolic processCytochrome P450 1A1Homo sapiens (human)
estrogen metabolic processCytochrome P450 1A1Homo sapiens (human)
amine metabolic processCytochrome P450 1A1Homo sapiens (human)
response to nematodeCytochrome P450 1A1Homo sapiens (human)
response to herbicideCytochrome P450 1A1Homo sapiens (human)
ethylene metabolic processCytochrome P450 1A1Homo sapiens (human)
coumarin metabolic processCytochrome P450 1A1Homo sapiens (human)
flavonoid metabolic processCytochrome P450 1A1Homo sapiens (human)
response to iron(III) ionCytochrome P450 1A1Homo sapiens (human)
insecticide metabolic processCytochrome P450 1A1Homo sapiens (human)
dibenzo-p-dioxin catabolic processCytochrome P450 1A1Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 1A1Homo sapiens (human)
response to foodCytochrome P450 1A1Homo sapiens (human)
response to lipopolysaccharideCytochrome P450 1A1Homo sapiens (human)
response to vitamin ACytochrome P450 1A1Homo sapiens (human)
response to immobilization stressCytochrome P450 1A1Homo sapiens (human)
vitamin D metabolic processCytochrome P450 1A1Homo sapiens (human)
retinol metabolic processCytochrome P450 1A1Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 1A1Homo sapiens (human)
9-cis-retinoic acid biosynthetic processCytochrome P450 1A1Homo sapiens (human)
camera-type eye developmentCytochrome P450 1A1Homo sapiens (human)
nitric oxide metabolic processCytochrome P450 1A1Homo sapiens (human)
response to arsenic-containing substanceCytochrome P450 1A1Homo sapiens (human)
digestive tract developmentCytochrome P450 1A1Homo sapiens (human)
tissue remodelingCytochrome P450 1A1Homo sapiens (human)
hydrogen peroxide biosynthetic processCytochrome P450 1A1Homo sapiens (human)
response to hyperoxiaCytochrome P450 1A1Homo sapiens (human)
maternal process involved in parturitionCytochrome P450 1A1Homo sapiens (human)
hepatocyte differentiationCytochrome P450 1A1Homo sapiens (human)
cellular response to copper ionCytochrome P450 1A1Homo sapiens (human)
omega-hydroxylase P450 pathwayCytochrome P450 1A1Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycleCytochrome P450 1A1Homo sapiens (human)
response to 3-methylcholanthreneCytochrome P450 1A1Homo sapiens (human)
lipid hydroxylationCytochrome P450 3A4Homo sapiens (human)
lipid metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid catabolic processCytochrome P450 3A4Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid metabolic processCytochrome P450 3A4Homo sapiens (human)
cholesterol metabolic processCytochrome P450 3A4Homo sapiens (human)
androgen metabolic processCytochrome P450 3A4Homo sapiens (human)
estrogen metabolic processCytochrome P450 3A4Homo sapiens (human)
alkaloid catabolic processCytochrome P450 3A4Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 3A4Homo sapiens (human)
calcitriol biosynthetic process from calciolCytochrome P450 3A4Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D metabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D catabolic processCytochrome P450 3A4Homo sapiens (human)
retinol metabolic processCytochrome P450 3A4Homo sapiens (human)
retinoic acid metabolic processCytochrome P450 3A4Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 3A4Homo sapiens (human)
aflatoxin metabolic processCytochrome P450 3A4Homo sapiens (human)
oxidative demethylationCytochrome P450 3A4Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 2A6Homo sapiens (human)
steroid metabolic processCytochrome P450 2A6Homo sapiens (human)
coumarin metabolic processCytochrome P450 2A6Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 2A6Homo sapiens (human)
coumarin catabolic processCytochrome P450 2A6Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 2A6Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 2B6Homo sapiens (human)
steroid metabolic processCytochrome P450 2B6Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 2B6Homo sapiens (human)
cellular ketone metabolic processCytochrome P450 2B6Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 2B6Homo sapiens (human)
lipid hydroxylationCytochrome P450 3A5Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 3A5Homo sapiens (human)
steroid metabolic processCytochrome P450 3A5Homo sapiens (human)
estrogen metabolic processCytochrome P450 3A5Homo sapiens (human)
alkaloid catabolic processCytochrome P450 3A5Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 3A5Homo sapiens (human)
retinol metabolic processCytochrome P450 3A5Homo sapiens (human)
retinoic acid metabolic processCytochrome P450 3A5Homo sapiens (human)
aflatoxin metabolic processCytochrome P450 3A5Homo sapiens (human)
oxidative demethylationCytochrome P450 3A5Homo sapiens (human)
long-chain fatty acid metabolic processCytochrome P450 4A11Homo sapiens (human)
renal water homeostasisCytochrome P450 4A11Homo sapiens (human)
pressure natriuresisCytochrome P450 4A11Homo sapiens (human)
fatty acid metabolic processCytochrome P450 4A11Homo sapiens (human)
leukotriene metabolic processCytochrome P450 4A11Homo sapiens (human)
arachidonic acid metabolic processCytochrome P450 4A11Homo sapiens (human)
epoxygenase P450 pathwayCytochrome P450 4A11Homo sapiens (human)
oxylipin biosynthetic processCytochrome P450 4A11Homo sapiens (human)
positive regulation of icosanoid secretionCytochrome P450 4A11Homo sapiens (human)
leukotriene B4 catabolic processCytochrome P450 4A11Homo sapiens (human)
sodium ion homeostasisCytochrome P450 4A11Homo sapiens (human)
omega-hydroxylase P450 pathwayCytochrome P450 4A11Homo sapiens (human)
linoleic acid metabolic processCytochrome P450 4A11Homo sapiens (human)
kidney developmentCytochrome P450 4A11Homo sapiens (human)
lauric acid metabolic processCytochrome P450 4A11Homo sapiens (human)
icosanoid biosynthetic processCytochrome P450 4A11Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (39)

Processvia Protein(s)Taxonomy
monooxygenase activityCytochrome P450 1A1Homo sapiens (human)
iron ion bindingCytochrome P450 1A1Homo sapiens (human)
protein bindingCytochrome P450 1A1Homo sapiens (human)
arachidonic acid monooxygenase activityCytochrome P450 1A1Homo sapiens (human)
oxidoreductase activityCytochrome P450 1A1Homo sapiens (human)
oxidoreductase activity, acting on diphenols and related substances as donorsCytochrome P450 1A1Homo sapiens (human)
flavonoid 3'-monooxygenase activityCytochrome P450 1A1Homo sapiens (human)
oxygen bindingCytochrome P450 1A1Homo sapiens (human)
enzyme bindingCytochrome P450 1A1Homo sapiens (human)
heme bindingCytochrome P450 1A1Homo sapiens (human)
Hsp70 protein bindingCytochrome P450 1A1Homo sapiens (human)
demethylase activityCytochrome P450 1A1Homo sapiens (human)
Hsp90 protein bindingCytochrome P450 1A1Homo sapiens (human)
aromatase activityCytochrome P450 1A1Homo sapiens (human)
vitamin D 24-hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
long-chain fatty acid omega-hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
hydroperoxy icosatetraenoate dehydratase activityCytochrome P450 1A1Homo sapiens (human)
long-chain fatty acid omega-1 hydroxylase activityCytochrome P450 1A1Homo sapiens (human)
monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
steroid bindingCytochrome P450 3A4Homo sapiens (human)
iron ion bindingCytochrome P450 3A4Homo sapiens (human)
protein bindingCytochrome P450 3A4Homo sapiens (human)
steroid hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
retinoic acid 4-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
oxidoreductase activityCytochrome P450 3A4Homo sapiens (human)
oxygen bindingCytochrome P450 3A4Homo sapiens (human)
enzyme bindingCytochrome P450 3A4Homo sapiens (human)
heme bindingCytochrome P450 3A4Homo sapiens (human)
vitamin D3 25-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
caffeine oxidase activityCytochrome P450 3A4Homo sapiens (human)
quinine 3-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
testosterone 6-beta-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 8,9 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 11,12 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 14,15 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
aromatase activityCytochrome P450 3A4Homo sapiens (human)
vitamin D 24-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1,8-cineole 2-exo-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
iron ion bindingCytochrome P450 2A6Homo sapiens (human)
coumarin 7-hydroxylase activityCytochrome P450 2A6Homo sapiens (human)
enzyme bindingCytochrome P450 2A6Homo sapiens (human)
heme bindingCytochrome P450 2A6Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochrome P450 2A6Homo sapiens (human)
arachidonic acid epoxygenase activityCytochrome P450 2A6Homo sapiens (human)
monooxygenase activityCytochrome P450 2B6Homo sapiens (human)
iron ion bindingCytochrome P450 2B6Homo sapiens (human)
testosterone 16-alpha-hydroxylase activityCytochrome P450 2B6Homo sapiens (human)
heme bindingCytochrome P450 2B6Homo sapiens (human)
testosterone 16-beta-hydroxylase activityCytochrome P450 2B6Homo sapiens (human)
anandamide 8,9 epoxidase activityCytochrome P450 2B6Homo sapiens (human)
anandamide 11,12 epoxidase activityCytochrome P450 2B6Homo sapiens (human)
anandamide 14,15 epoxidase activityCytochrome P450 2B6Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 2B6Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochrome P450 2B6Homo sapiens (human)
arachidonic acid epoxygenase activityCytochrome P450 2B6Homo sapiens (human)
monooxygenase activityCytochrome P450 3A5Homo sapiens (human)
iron ion bindingCytochrome P450 3A5Homo sapiens (human)
protein bindingCytochrome P450 3A5Homo sapiens (human)
retinoic acid 4-hydroxylase activityCytochrome P450 3A5Homo sapiens (human)
oxidoreductase activityCytochrome P450 3A5Homo sapiens (human)
oxygen bindingCytochrome P450 3A5Homo sapiens (human)
heme bindingCytochrome P450 3A5Homo sapiens (human)
aromatase activityCytochrome P450 3A5Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 3A5Homo sapiens (human)
testosterone 6-beta-hydroxylase activityCytochrome P450 3A5Homo sapiens (human)
monooxygenase activityCytochrome P450 4A11Homo sapiens (human)
iron ion bindingCytochrome P450 4A11Homo sapiens (human)
arachidonic acid epoxygenase activityCytochrome P450 4A11Homo sapiens (human)
alkane 1-monooxygenase activityCytochrome P450 4A11Homo sapiens (human)
heme bindingCytochrome P450 4A11Homo sapiens (human)
leukotriene-B4 20-monooxygenase activityCytochrome P450 4A11Homo sapiens (human)
aromatase activityCytochrome P450 4A11Homo sapiens (human)
long-chain fatty acid omega-hydroxylase activityCytochrome P450 4A11Homo sapiens (human)
arachidonic acid monooxygenase activityCytochrome P450 4A11Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
mitochondrial inner membraneCytochrome P450 1A1Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 1A1Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 1A1Homo sapiens (human)
cytoplasmCytochrome P450 3A4Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 3A4Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 3A4Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 2A6Homo sapiens (human)
cytoplasmic microtubuleCytochrome P450 2A6Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 2A6Homo sapiens (human)
cytoplasmCytochrome P450 2A6Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 2B6Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 2B6Homo sapiens (human)
cytoplasmCytochrome P450 2B6Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 3A5Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 3A5Homo sapiens (human)
cytoplasmCytochrome P450 4A11Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 4A11Homo sapiens (human)
apical plasma membraneCytochrome P450 4A11Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 4A11Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 4A11Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (26)

Assay IDTitleYearJournalArticle
AID1216026Apparent intrinsic clearance assessed as ratio of Vmax to Km for human recombinant CYP3A5-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216011Drug metabolism assessed as human recombinant CYP3A5-mediated 17-hydroexemestane formation rate per pmol of enzyme at 10 uM after 10 mins2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215989Drug metabolism assessed as human recombinant CYP3A5-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216009Drug metabolism assessed as human recombinant CYP4A11-mediated 17-hydroexemestane formation rate per pmol of enzyme at 10 uM after 10 mins2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216022Drug metabolism in human liver microsomes assessed as 17-hydroexemestane formation at 10 uM after 10 mins by LC-MS/MS analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215970Apparent intrinsic clearance assessed as ratio of Vmax to Km for human recombinant CYP1A1-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216013Drug metabolism assessed as human recombinant CYP2C9-mediated 17-hydroexemestane formation rate per pmol of enzyme at 10 uM after 10 mins2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215993Drug metabolism assessed as human recombinant CYP4A11-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215971Apparent intrinsic clearance assessed as ratio of Vmax to Km for human recombinant CYP4A11-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215992Drug metabolism assessed as human recombinant CYP1A1-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215991Drug metabolism assessed as human recombinant CYP2A6-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216027Apparent intrinsic clearance assessed as ratio of Vmax to Km for human recombinant CYP2B6-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216019Drug metabolism in human liver microsomes assessed as 17-hydroexemestane formation after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216008Drug metabolism assessed as human recombinant CYP2A6-mediated 17-hydroexemestane formation rate per pmol of enzyme at 10 uM after 10 mins2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215969Apparent intrinsic clearance assessed as ratio of Vmax to Km for human recombinant CYP2A6-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216024Drug metabolism assessed as human recombinant CYP3A4-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215983Drug metabolism assessed as human recombinant CYP19-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216012Drug metabolism assessed as human recombinant CYP2B6-mediated 17-hydroexemestane formation rate per pmol of enzyme at 10 uM after 10 mins2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215984Drug metabolism assessed as human recombinant CYP1A2-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216025Apparent intrinsic clearance assessed as ratio of Vmax to Km for human recombinant CYP3A4-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216014Drug metabolism assessed as human recombinant CYP2C19-mediated 17-hydroexemestane formation rate per pmol of enzyme at 10 uM after 10 mins2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216016Drug metabolism in human liver microsomes assessed as retention time treated with 300 uM of exemestane after 10 mins by HPLC with UV analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216010Drug metabolism assessed as human recombinant CYP3A4-mediated 17-hydroexemestane formation rate per pmol of enzyme at 10 uM after 10 mins2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1215990Drug metabolism assessed as human recombinant CYP2B6-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216007Drug metabolism assessed as human recombinant CYP1A1-mediated 17-hydroexemestane formation rate per pmol of enzyme at 10 uM after 10 mins2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
AID1216020Apparent intrinsic clearance in human liver microsomes assessed as ratio of Vmax to Km for 17-hydroexemestane formation after 10 mins by Michaelis-Menten saturation curve analysis2011Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 39, Issue:1
In vitro cytochrome P450-mediated metabolism of exemestane.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
anastrozole
[no description available]		3.2310nitrile;
triazoles		antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
aromasil
[no description available]		4.14017-oxo steroid;
3-oxo-Delta(1),Delta(4)-steroid		antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor;
environmental contaminant;
xenobiotic
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		3.23101,2,3-triazole
tamoxifen
[no description available]		3.2310stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		03.0410
Breast Neoplasms
Tumors or cancer of the human BREAST.		03.0410
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0510