Page last updated: 2024-09-27

Delayed Awakening from Anesthesia

Postoperative morbidity in patients recovering from general anesthesia where a depressed neuromuscular response due to residual PARESIS continues beyond a defined ANESTHESIA RECOVERY PERIOD.

Synonyms(14)

Synonym
Postoperative Residual Curarisation
Residual Neuromuscular Blockade
Postoperative Residual Curarization
Postoperative Residual Weakness
Delayed Awakening, Post-Procedural
Residual Paralysis, Post-Anesthesia
Delayed Emergence from Anesthesia
Residual Block
Delayed Regaining of Consciousness
Delayed Recovery from Anesthesia
Delayed Awakening from Anesthesia
Residual Neuromuscular Block
Delayed Awakening, Post-Anesthesia
Delayed Return of Consciousness

Research Excerpts

Overview

ExcerptReference
"Postoperative residual curarization is still a problem of the modern anesthesia."( Della Rocca, G; Pompei, L, 2009)
"Postoperative residual curarization is a topic of paramount importance, because its occurrence can cause complications and increase the length of stay in hospital and the related costs."( Adembri, C; Cappellini, I; Danti, G; De Gaudio, AR; Ostento, D; Picciafuochi, F, 2018)
"Then, the residual block is designed to extract higher level, distinguishable features from molecular graph features."( Lam, KM; Liu, M; Sun, ZL; Zeng, Z, 2022)
"Residual neuromuscular blockade is associated with significant morbidity."( Moore, JE; Ramsay, DP; Ross, J; Sutton-Smith, LJ; Willink, RD, 2022)

Context

ExcerptReference
"Residual neuromuscular block has been associated with postoperative pulmonary complications."( Aziz, MF; Higgins, JR; Tekkali, P; Togioka, BM; Treggiari, MM; Yanez, D, 2020)

Research

Studies (108)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's6 (5.56)18.1394
2010's64 (59.26)28.8240
2020's38 (35.19)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
ammonium hydroxide0low10
glycine0low10
nitrous oxide0low10
phenytoin0low10
caffeine0low10
clobazam0low10
clonazepam0low10
valproic acid0low10
doxapram0low10
edrophonium0low20
fentanyl0medium31
flumazenil0medium21
isoflurane0medium52
ketamine0medium51
midazolam0medium31
apnea0low30
neostigmine0medium4614
phenobarbital0low10
propofol0medium133
sevoflurane0medium61
succinylcholine0medium41
glycopyrrolate0medium11
magnesium sulfate0low10
vecuronium bromide0low40
sufentanil0low10
desflurane0medium22
atracurium0medium72
colforsin0low10
simvastatin0low10
remifentanil0medium73
cisatracurium0medium42
triazoles0low10
atropine0low10
ropivacaine0low10
tricaine0low10
rocuronium0medium348
thiopental0medium11
mivacurium0low10
nalmefene0low10
gamma-cyclodextrin0low10
dexmedetomidine0medium41
naltrexone0low10
phosphocreatine0medium11
mitoquinone0low10
ubiquinone0low10
piperidines0medium52

Protein Targets (451)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma7007
TDP1 protein7007
AR protein100010
nuclear receptor subfamily 1, group I, member 39009
cytochrome P450 family 3 subfamily A polypeptide 46006
glucocorticoid receptor [Homo sapiens]8008
estrogen-related nuclear receptor alpha8008
pregnane X nuclear receptor100010
estrogen nuclear receptor alpha120012
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
nuclear factor erythroid 2-related factor 2 isoform 23003
heat shock protein beta-13003
importin subunit beta-1 isoform 11001
snurportin-11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta108008
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump015015
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Glutamate receptor 23003
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 434004
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 54004
Ataxin-24004
thioredoxin reductase5005
ATAD5 protein, partial1001
Microtubule-associated protein tau2002
arylsulfatase A4004
euchromatic histone-lysine N-methyltransferase 2110011
Bloom syndrome protein isoform 14004
D(1A) dopamine receptor3003
neuropeptide S receptor isoform A1001
NPYLR7B0011
Amine oxidase [flavin-containing] A 0011
Small conductance calcium-activated potassium channel protein 30112
Chain A, 2-oxoglutarate Oxygenase1001
GLI family zinc finger 36006
retinoid X nuclear receptor alpha4004
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta2002
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0505
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
5-hydroxytryptamine receptor 40404
Muscarinic acetylcholine receptor M20418
Muscarinic acetylcholine receptor M40316
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30215
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M50316
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M10317
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30417
Alpha-1D adrenergic receptor0303
5-hydroxytryptamine receptor 2C0404
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor2003
5-hydroxytryptamine receptor 70101
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0113
Canalicular multispecific organic anion transporter 10909
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 20022
Potassium channel subfamily K member 90202
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
phosphopantetheinyl transferase2002
GLS protein5005
retinoic acid nuclear receptor alpha variant 19009
farnesoid X nuclear receptor5005
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
atrial natriuretic peptide receptor 1 precursor2002
chromobox protein homolog 14004
thyroid hormone receptor beta isoform a3003
thyroid hormone receptor beta isoform 25005
nuclear factor erythroid 2-related factor 2 isoform 17007
nuclear receptor ROR-gamma isoform 13003
geminin9009
DNA polymerase kappa isoform 11001
muscarinic acetylcholine receptor M16006
lethal factor (plasmid)1001
Glycogen phosphorylase, muscle form0101
Renin0101
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Cholinesterase0404
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0101
Adenosine receptor A30101
Replicase polyprotein 1ab0101
Amine oxidase [flavin-containing] A0202
Acetylcholinesterase0404
Adenosine receptor A10203
Amine oxidase [flavin-containing] B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A30101
Adenosine receptor A2a0214
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10114
Adenosine receptor A2a0204
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10113
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Guanine deaminase0101
ATP-dependent phosphofructokinase1001
nuclear receptor subfamily 1, group I, member 24004
Gamma-aminobutyric acid receptor subunit pi0404
Gamma-aminobutyric acid receptor subunit pi27110
Gamma-aminobutyric acid receptor subunit delta0404
Gamma-aminobutyric acid receptor subunit alpha-10305
Gamma-aminobutyric acid receptor subunit beta-10305
Neuronal acetylcholine receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit alpha-20305
Gamma-aminobutyric acid receptor subunit alpha-30305
Neuronal acetylcholine receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-10527
Gamma-aminobutyric acid receptor subunit beta-127110
Gamma-aminobutyric acid receptor subunit beta-10415
Gamma-aminobutyric acid receptor subunit delta27110
Gamma-aminobutyric acid receptor subunit gamma-20527
Gamma-aminobutyric acid receptor subunit gamma-227110
Gamma-aminobutyric acid receptor subunit alpha-527110
Gamma-aminobutyric acid receptor subunit alpha-327110
Gamma-aminobutyric acid receptor subunit alpha-40305
Gamma-aminobutyric acid receptor subunit gamma-20305
Gamma-aminobutyric acid receptor subunit gamma-127110
Gamma-aminobutyric acid receptor subunit alpha-227110
Gamma-aminobutyric acid receptor subunit alpha-427110
Gamma-aminobutyric acid receptor subunit beta-30527
Gamma-aminobutyric acid receptor subunit gamma-327110
Gamma-aminobutyric acid receptor subunit alpha-627110
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50426
Gamma-aminobutyric acid receptor subunit alpha-30426
Gamma-aminobutyric acid receptor subunit alpha-20415
Gamma-aminobutyric acid receptor subunit beta-20415
Gamma-aminobutyric acid receptor subunit alpha-40415
Gamma-aminobutyric acid receptor subunit alpha-127110
Gamma-aminobutyric acid receptor subunit beta-327110
Gamma-aminobutyric acid receptor subunit beta-227110
Gamma-aminobutyric acid receptor subunit epsilon0404
Gamma-aminobutyric acid receptor subunit alpha-60415
Gamma-aminobutyric acid receptor subunit gamma-10404
GABA theta subunit27110
Gamma-aminobutyric acid receptor subunit gamma-30404
Gamma-aminobutyric acid receptor subunit epsilon27110
Gamma-aminobutyric acid receptor subunit theta0404
glp-1 receptor, partial1001
pregnane X receptor2002
estrogen receptor 2 (ER beta)2002
progesterone receptor3003
G5005
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
aryl hydrocarbon receptor2002
nuclear receptor subfamily 0 group B member 10101
steroidogenic factor 10101
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peripheral myelin protein 225005
relaxin receptor 1 isoform 11001
relaxin receptor 2 isoform 11001
Nuclear receptor subfamily 1 group I member 20022
Rap guanine nucleotide exchange factor 32002
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p536006
ATP-dependent translocase ABCB10505
5-hydroxytryptamine receptor 1A0101
Solute carrier family 2, facilitated glucose transporter member 10011
Adenylate cyclase type 20011
Adenylate cyclase type 80011
Inositol hexakisphosphate kinase 15005
Relaxin receptor 10011
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial5005
thyroid stimulating hormone receptor4004
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 12002
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor2002
cytochrome P450 3A4 isoform 12002
Alpha-2A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
Alpha-1A adrenergic receptor0011
Alpha-2C adrenergic receptor0112
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0112
Alpha-1A adrenergic receptor0112
Cytochrome P450 2D60203
dopamine D1 receptor1001
POU domain, class 2, transcription factor 10001
Acetylcholinesterase0202
Luciferase2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
D(2) dopamine receptor0101
D(4) dopamine receptor0101
Delta-type opioid receptor0416
Delta-type opioid receptor0516
Mu-type opioid receptor0729
Kappa-type opioid receptor0415
Histamine H1 receptor0101
Mu-type opioid receptor05513
D(3) dopamine receptor0101
Delta-type opioid receptor05311
Kappa-type opioid receptor0506
Kappa-type opioid receptor05110
Mu-type opioid receptor0315
Mu-type opioid receptor0416
Potassium voltage-gated channel subfamily H member 20303
Sigma non-opioid intracellular receptor 10606
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10101
endonuclease IV2002
aldehyde dehydrogenase 1 family, member A12002
regulator of G-protein signaling 44004
EWS/FLI fusion protein2002
flap endonuclease 12002
survival motor neuron protein isoform d1001
muscleblind-like protein 1 isoform 12002
Bile salt export pump0202
5-hydroxytryptamine receptor 1A0202
Neuronal acetylcholine receptor subunit alpha-70101
Chain A, Glycogen phosphorylase, muscle form0101
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0415
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0415
Glutamate receptor ionotropic, NMDA 2B0415
Glutamate receptor ionotropic, NMDA 2C0415
Large neutral amino acids transporter small subunit 10101
Glutamate receptor ionotropic, NMDA 2D0415
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0415
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0415
Sodium- and chloride-dependent glycine transporter 20101
cytochrome P450 2D65005
vitamin D3 receptor isoform VDRA2002
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0202
Glutamate receptor ionotropic, NMDA 3B0101
Sodium channel protein type 4 subunit alpha0203
Cholinesterase0202
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 3A0101
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40101
Translocator protein0101
UDP-glucuronosyltransferase 2B70203
UDP-glucuronosyltransferase 1-60102
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0102
UDP-glucuronosyltransferase 1A40101
UDP-glucuronosyltransferase 2B10 0101
Fumarate hydratase1001
polyprotein1001
kappa-type opioid receptor isoform 10101
Spike glycoprotein3003
Beta-galactosidase0011
5-hydroxytryptamine receptor 3E0101
5-hydroxytryptamine receptor 3B0101
Histidine decarboxylase0011
Kappa-type opioid receptor0213
Nociceptin receptor0101
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
UDP-glucuronosyltransferase 1A80002
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Gamma-aminobutyric acid 0101
peripheral myelin protein 22 isoform 11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
transcriptional regulator ERG isoform 31001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Dihydrofolate reductase 0101
Sodium channel protein type 2 subunit alpha0101
Cytochrome P450 2C9 0101
Aldo-keto reductase family 1 member B10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Inositol monophosphatase 11001
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Chain A, Ferritin light chain3003
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
USP1 protein, partial2002
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
caspase-31001
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
Histone H2A.x2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase iota isoform a (long)1001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90002
Aldo-keto reductase family 1 member B10303
Polyunsaturated fatty acid lipoxygenase ALOX150101
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
Sodium- and chloride-dependent GABA transporter 10202
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
5-hydroxytryptamine receptor 2B0202
Sodium- and chloride-dependent betaine transporter0202
Fatty-acid amide hydrolase 10202
Chain A, Beta-lactamase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
hypoxia-inducible factor 1 alpha subunit1001
SMAD family member 21001
SMAD family member 31001
Smad31001
PINK11001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
photoreceptor-specific nuclear receptor0101
IDH11001
serine/threonine-protein kinase PLK11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Insulin receptor 0101
Prostaglandin G/H synthase 20101
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Solute carrier organic anion transporter family member 1B10101
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
histone acetyltransferase KAT2A isoform 11001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Cocaine esterase0101
Histone deacetylase 30202
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Nuclear receptor ROR-gamma1001
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
acetylcholinesterase1001
Solute carrier family 22 member 20101
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]