triazoles has been researched along with gamma-aminobutyric acid in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.33) | 18.7374 |
| 1990's | 19 (25.33) | 18.2507 |
| 2000's | 30 (40.00) | 29.6817 |
| 2010's | 21 (28.00) | 24.3611 |
| 2020's | 1 (1.33) | 2.80 |
| Authors | Studies |
|---|---|
| Beer, B; Benson, DI; Klepner, CA; Lippa, AS; Sano, MC | 1 |
| Ashton, D; Willems, R | 1 |
| Kane, JM; Sorensen, SM; Zwolshen, JM | 1 |
| Barone, D; Corsico, N; Luzzani, F; Occelli, E; Tarzia, G | 1 |
| Dudley, MW; Kane, JM; Miller, FP; Sorensen, SM | 1 |
| Armstrong, DR; Breckenridge, RJ; Suckling, CJ | 1 |
| Bain, CJ; Kemp, JA; McKernan, RM; Quirk, K; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Bain, C; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Biggio, G; Ghiani, CA; Maciocco, E; Sanna, E; Serra, M; Tuligi, G | 1 |
| Ambrogi, V; Giannaccini, G; Grandolini, G; Lucacchini, A; Martini, C; Perioli, L | 1 |
| Kapur, J; Macdonald, RL | 1 |
| Stevenson, A; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Braun, D; Chmielewski, PA; Kane, JM; Miller, JA | 1 |
| Korpi, ER; Matecka, D; Sarviharju, M; Toropainen, M; Wong, G | 1 |
| Hosie, AM; Sattelle, DB | 1 |
| Donnelly, JL; MacDonald, RL | 1 |
| Biggio, G; Casula, A; Maciocco, E; Murgia, A; Sanna, E; Tuligi, G; Usala, M | 1 |
| Bac, P; Dupont, C; Evrard, P; Gressens, P; Maurois, P; Pages, N; Stables, JP; Vamecq, J | 1 |
| Greenfield, LJ; Macdonald, RL; Neelands, TR; Turner, RS; Zhang, J | 1 |
| Bianchi, M; Fisher, JL; Macdonald, RL; Neelands, TR | 1 |
| Korpi, ER; Mäkelä, R; Wisden, W | 1 |
| Kapur, J; Macdonald, RL; Tietz, EI | 1 |
| Macdonald, RL; Neelands, TR | 1 |
| Sapp, DW; Yeh, HH | 1 |
| Agostinho, P; Cunha, RA; Melo, J; Oliveira, CR; Rego, AC | 1 |
| Saxena, NC | 1 |
| Feigenspan, A; Gustincich, S; Raviola, E | 1 |
| Baur, R; Dodd, RH; Sigel, E; Thomet, U | 1 |
| Hevers, W; Korpi, ER; Lüddens, H | 1 |
| Aldenkamp, AP | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Pisani, A; Saulle, E | 1 |
| Cunha, RA; Fredholm, BB; Kull, B; Lopes, LV; Ribeiro, JA | 1 |
| Dillon, GH; Huang, RQ | 1 |
| Choi, JI; Jeong, SW; Yoon, MH | 1 |
| Walson, PD | 1 |
| Bacci, A; Huguenard, JR; Prince, DA; Rudolph, U | 1 |
| DuBois, DW; Frye, GD; Hsiao, SH; Miranda, RC | 1 |
| Konishi, S; Rusakov, D; Saitow, F; Satake, S | 1 |
| Kapur, J; Mtchedlishvili, Z | 1 |
| Baur, R; Boulineau, N; Minier, F; Sigel, E | 1 |
| Berrino, L; de Novellis, V; Maione, S; Marabese, I; Mariani, L; Oliva, P; Palazzo, E; Rossi, F; Scafuro, M; Siniscalco, D | 1 |
| Alexander, SP; Beckett, SR; Harper, LK; Marsden, CA; McCreary, AC | 1 |
| Baghdoyan, HA; Coleman, CG; Lydic, R | 1 |
| Aceves, J; Erlij, D; Florán, B; Florán, L; Gonzalez, B; Paz, F | 1 |
| Hussar, DA | 1 |
| Disteldorf, E; Jarry, H; Lehan, N; Mares, U; Rune, GM; von Lossow, R; Wehrenberg, U; Zhou, L | 1 |
| Burkhart, KK; Rasimas, JJ | 1 |
| Miura, Y | 1 |
| Grzelak, ME; Hodgson, RA; Hunter, JC; Parker, EM; Pond, AJ; Varty, GB | 1 |
| Arcella, A; Cantore, G; Di Gennaro, G; Esposito, V; Eusebi, F; Fredholm, BB; Fucile, S; Limatola, C; Manfredi, M; Martinello, K; Mascia, A; Miledi, R; Piccari, V; Quarato, PP; Roseti, C; Simonato, M | 1 |
| Bostwick, R; Chen, T; Huston, J; Knappenberger, K; Liu, J; Norris, T; Wood, M | 1 |
| Bundzikova, J; Hansen, HH; Kiss, A; Larsen, MH; Mikkelsen, JD | 1 |
| Guan, LP; Jiang, Z; Piao, HR; Quan, ZS; Zhao, DH | 1 |
| Dunn, PJ | 1 |
| Möhler, H | 1 |
| Cohen, AF; de Haas, SL; De Smet, M; Gottesdiener, KM; Murphy, MG; Rosen, LB; Schoemaker, RC; Van Dyck, K; van Gerven, JM; Zoethout, RW | 1 |
| Bisaga, A; Cheng, WY; Horey, JT; Levin, FR; Mariani, JJ; Nunes, E; Sullivan, M | 1 |
| Brown, DT; Erichsen, HK; Hansen, RR; Mirza, NR; Munro, G | 1 |
| Hopkins, CR | 1 |
| Cao, X; Deng, XQ; Quan, ZS; Shu, B; Wang, SB | 1 |
| Binns, J; Bowlby, MR; Brunner, J; Cannon, CE; Coleman, PJ; Eddins, DM; Fox, SV; Garson, SL; Gotter, AL; Hodgson, R; Kuduk, SD; Mcdonald, TP; Renger, JJ; Savitz, AT; Stevens, J; Tannenbaum, PL; Tye, SJ; Uslaner, JM; Wang, X; Winrow, CJ; Yao, L | 1 |
| Bleickardt, CJ; Boykow, G; Browne, SE; Hill, D; Hodge, LM; Hodgson, RA; Innocent, N; Jayaraman, S; Lis, E; Mullins, DE; Parker, EM; Reynolds, IJ; Rittle, SL; Smith, KM; Yao, L | 1 |
| Baum, L; Chan, PS; Kwan, P; Zhang, C; Zuo, Z | 1 |
| Arias-Montaño, JA; Escamilla-Sánchez, J; González-Pantoja, R; Márquez-Gómez, R; Morales-Figueroa, GE | 1 |
| Ito, S; Oguni, H | 1 |
| Ohtsuka, Y | 1 |
| Filip, M; Fuxe, K; Gołembiowska, K; Kamińska, K; Suder, A; Wydra, K | 1 |
| Chaki, S; Hiyoshi, T; Kambe, D; Karasawa, J | 1 |
| Diógenes, MJ; Lérias, SR; Parreira, S; Sebastião, AM; Vaz, SH | 1 |
| Coleman, PJ; Fox, SV; Gotter, AL; Hodgson, R; Ramirez, AD; Renger, JJ; Roecker, AJ; Smith, SM; Uslaner, JM; Winrow, CJ; Yao, L | 1 |
| Afsar, T; Almajwal, A; Jahan, S; Pirzada, M; Rauf, N; Razak, S; Ullah, A; Ullah, H | 1 |
| Charalambous, C; Havlickova, T; Jerabek, P; Lapka, M; Puskina, N; Sustkova-Fiserova, M; Syslova, K | 1 |
| Chaudhari, N; Dawalbhakta, M; Nampoothiri, L | 1 |
| Boschi, D; Frølund, B; Giraudo, A; Kongstad, KT; Krall, J; Lolli, ML; Nielsen, B; Rolando, B; Sørensen, TE | 1 |
| Charalambous, C; Havlickova, T; Lapka, M; Sustkova-Fiserova, M; Syslova, K | 1 |
6 review(s) available for triazoles and gamma-aminobutyric acid
| Article | Year |
|---|---|
[A new aspect in the research on antiepileptic drugs].
Topics: Acetamides; Amines; Animals; Anticonvulsants; Benzodiazepines; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Humans; Lacosamide; Levetiracetam; Phenylenediamines; Piracetam; Pregabalin; Pregnanolone; Pyrrolidinones; Triazoles | 2007 |
The importance of green chemistry in process research and development.
Topics: Biocatalysis; Fluorobenzenes; gamma-Aminobutyric Acid; Green Chemistry Technology; Lipase; Pharmaceutical Preparations; Pregabalin; Pyrazines; Pyrimidines; Rosuvastatin Calcium; Sitagliptin Phosphate; Solvents; Sulfonamides; Transaminases; Triazoles | 2012 |
The GABA system in anxiety and depression and its therapeutic potential.
Topics: Antidepressive Agents; Anxiety; Depression; GABA Agonists; gamma-Aminobutyric Acid; Humans; Neural Pathways; Pyridazines; Receptors, GABA; Triazoles | 2012 |
ACS chemical neuroscience molecule spotlight on Suvorexant.
Topics: Animals; Azepines; Clinical Trials, Phase I as Topic; Clinical Trials, Phase III as Topic; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Intracellular Signaling Peptides and Proteins; Neuropeptides; Orexins; Sleep Initiation and Maintenance Disorders; Triazoles | 2012 |
[Treatment of pediatric epilepsy].
Topics: Adolescent; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Dioxolanes; Drug Approval; Drug Substitution; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Lamotrigine; Levetiracetam; Patient Education as Topic; Piracetam; Practice Guidelines as Topic; Topiramate; Triazines; Triazoles; Valproic Acid | 2014 |
[New antiepileptic drugs: characteristics and clinical applications].
Topics: Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dioxolanes; Drug Approval; Drug Interactions; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Japan; Lamotrigine; Levetiracetam; Piracetam; Safety; Topiramate; Triazines; Triazoles | 2014 |
2 trial(s) available for triazoles and gamma-aminobutyric acid
| Article | Year |
|---|---|
The effects of TPA023, a GABAAα2,3 subtype-selective partial agonist, on essential tremor in comparison to alcohol.
Topics: Benzodiazepines; Central Nervous System; Cross-Over Studies; Double-Blind Method; Emotions; Essential Tremor; Ethanol; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pyridazines; Receptors, GABA-A; Saccades; Triazoles | 2012 |
Comparison of substance use milestones in cannabis- and cocaine-dependent patients.
Topics: Adult; Age of Onset; Amines; Antidepressive Agents, Second-Generation; Bupropion; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Combinations; Excitatory Amino Acid Antagonists; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Marijuana Abuse; Piperazines; Triazoles; Young Adult | 2012 |
67 other study(ies) available for triazoles and gamma-aminobutyric acid
| Article | Year |
|---|---|
Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors.
Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Membranes; Rats; Receptors, Drug; Synaptosomes; Triazoles | 1979 |
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Pentobarbital; Phenobarbital; Triazoles | 1992 |
The effects of a potential antidepressant, 2,4-dimethyl-5-(3-fluorophenyl)-3H-1,2,4-triazole-3-thione, in an electrophysiological model responsive to desipramine.
Topics: Action Potentials; Animals; Antidepressive Agents; Desipramine; Electrophysiology; gamma-Aminobutyric Acid; Male; Models, Biological; Norepinephrine; Purkinje Fibers; Rats; Rats, Inbred Strains; Triazoles | 1990 |
Benzodiazepine receptor ligands. Synthesis and preliminary pharmacological evaluation of some 3-aryl-6-thioalkyl-, 3-aryl-6-alkylsulphinyl-, 3-aryl-6-alkylsulphonyl-, and 3-aryl-6-alkoxy-1,2,4-triazolo[3,4-a]phthalazines.
Topics: Animals; Anticonvulsants; Avoidance Learning; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Muscle Relaxants, Central; Phthalazines; Pyridazines; Receptors, GABA-A; Sulfides; Sulfones; Triazoles | 1988 |
2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents.
Topics: Animals; Antidepressive Agents; Desipramine; gamma-Aminobutyric Acid; Male; Mice; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triazoles | 1988 |
Muscimol and some aza analogues: molecular orbital calculations relating to their potency as GABA mimetics.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Electrons; gamma-Aminobutyric Acid; Humans; Molecular Conformation; Muscimol; Oxazoles; Pyrazoles; Pyrazolones; Receptors, Neurotransmitter; Rotation; Structure-Activity Relationship; Triazoles | 1982 |
A novel allosteric modulatory site on the GABAA receptor beta subunit.
Topics: Allosteric Site; Animals; Anticonvulsants; Cells, Cultured; Chlorides; Drug Synergism; Electric Conductivity; Electrophysiology; Female; gamma-Aminobutyric Acid; Gene Expression; Humans; Pentobarbital; Pregnanolone; Rats; Receptors, GABA; Transfection; Triazoles; Xenopus | 1994 |
The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.
Topics: Allosteric Site; Amino Acid Sequence; Animals; Anticonvulsants; Base Sequence; DNA Primers; DNA, Complementary; Dose-Response Relationship, Drug; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Polymerase Chain Reaction; Receptors, GABA-A; Recombinant Fusion Proteins; Triazoles; Xenopus | 1994 |
Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain.
Topics: Anesthetics; Animals; Anticonvulsants; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles; Tritium | 1996 |
Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. X--Synthesis and inhibition of benzodiazepine receptor binding of new 1,4-thiazine and 1,5-thiazepine polycondensed heterocycles with steroidal structure.
Topics: Animals; Binding, Competitive; Cattle; Cerebral Cortex; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Quinolines; Receptors, GABA-A; Thiazines; Triazoles | 1996 |
Pharmacological properties of gamma-aminobutyric acidA receptors from acutely dissociated rat dentate granule cells.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Carbolines; Chlorides; Convulsants; Dentate Gyrus; Diazepam; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc Compounds; Zolpidem | 1996 |
beta-Carboline gamma-aminobutyric acidA receptor inverse agonists modulate gamma-aminobutyric acid via the loreclezole binding site as well as the benzodiazepine site.
Topics: Animals; Anticonvulsants; Benzodiazepines; Binding Sites; Carbolines; Convulsants; Drug Synergism; Female; GABA Agonists; gamma-Aminobutyric Acid; Isomerism; Macromolecular Substances; Oocytes; Point Mutation; Receptors, GABA; Triazoles; Xenopus | 1995 |
The enhancement of muscimol-stimulated 36C1 influx by the antispastic 5-aryl-3-(alkylsulfonyl)-4H-1,2,4-triazole (MDL 27,531) in rat brain membrane vesicles.
Topics: Animals; Brain Chemistry; Chloride Channels; Chlorine; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Muscimol; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 1995 |
Pharmacologic actions of subtype-selective and novel GABAergic ligands in rat lines with differential sensitivity to ethanol.
Topics: Animals; Autoradiography; Binding, Competitive; Diazepam; Dose-Response Relationship, Drug; Ethanol; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Motor Activity; Pyridines; Rats; Triazoles; Zolpidem | 1996 |
Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster.
Topics: Allosteric Regulation; Animals; Chloride Channels; Dose-Response Relationship, Drug; Drosophila melanogaster; GABA Modulators; gamma-Aminobutyric Acid; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA; Triazoles; Xenopus | 1996 |
Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents.
Topics: Animals; Anticonvulsants; Cell Line; Cerebral Cortex; Electrophysiology; Fibroblasts; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Recombinant Proteins; Triazoles | 1996 |
Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; DNA, Complementary; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Macromolecular Substances; Male; Membrane Potentials; Oocytes; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis | 1996 |
Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Azepines; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Locomotion; Magnesium Deficiency; Melatonin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Neuroprotective Agents; Platelet Aggregation Inhibitors; Triazoles | 1998 |
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells.
Topics: Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Diuretics; DNA Primers; Furosemide; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Lanthanum; Neurons; Patch-Clamp Techniques; Pentobarbital; Phenobarbital; Picrotoxin; Polymerase Chain Reaction; Pregnanediones; Pregnenolone; Pyridines; Receptors, GABA-A; RNA, Messenger; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem | 1998 |
Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Furosemide; gamma-Aminobutyric Acid; Lanthanum; Mice; Pentobarbital; Protein Isoforms; Rats; Receptors, GABA-A; Triazoles; Zinc | 1999 |
Loreclezole and La3+ differentiate cerebellar granule cell GABA(A) receptor subtypes.
Topics: Animals; Anticonvulsants; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; gamma-Aminobutyric Acid; In Vitro Techniques; Lanthanum; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mutation; Radioligand Assay; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles | 1999 |
Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Membrane Potentials; Patch-Clamp Techniques; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc; Zolpidem | 1999 |
Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors.
Topics: Animals; Barbiturates; Benzodiazepines; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Lanthanum; Mice; Rats; Receptors, GABA-A; Recombinant Fusion Proteins; Steroids; Triazoles; Zinc | 1999 |
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Humans; Neuroblastoma; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Zinc | 2000 |
Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells.
Topics: Adenosine; Analysis of Variance; Animals; Aspartic Acid; Bicuculline; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Extracellular Space; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycolysis; Humans; Ischemia; Organophosphorus Compounds; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Retina; Triazines; Triazoles; Xanthines | 2000 |
Inhibition of GABA(A) receptor (GABAR) currents by arachidonic acid in HEK 293 cells stably transfected with alpha1beta2gamma2 GABAR subunits.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Anticonvulsants; Arachidonic Acid; Binding, Competitive; Cells, Cultured; Cyclooxygenase Inhibitors; Diazepam; Dose-Response Relationship, Drug; Fatty Acids; Fatty Acids, Monounsaturated; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Indomethacin; Kidney; Linoleic Acid; Masoprocol; Membrane Potentials; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Transfection; Triazoles | 2000 |
Pharmacology of GABA(A) receptors of retinal dopaminergic neurons.
Topics: Alkaline Phosphatase; Animals; Benzodiazepines; Bicuculline; Binding Sites; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Neurons; Osmolar Concentration; Patch-Clamp Techniques; Picrotoxin; Pregnanediones; Protein Isoforms; Receptors, GABA-A; Retina; Sesterterpenes; Triazoles; Zinc | 2000 |
Loreclezole as a simple functional marker for homomeric rho type GABA(C) receptors.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Membrane Potentials; Receptors, GABA; Receptors, GABA-B; Triazoles; Xenopus | 2000 |
Assembly of functional alpha6beta3gamma2delta GABA(A) receptors in vitro.
Topics: Affinity Labels; Anesthetics; Animals; Anticonvulsants; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Desoxycorticosterone; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Membrane Potentials; Muscimol; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Transfection; Triazoles; Tritium | 2000 |
Effects of antiepileptic drugs on cognition.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; Triazoles; Vigabatrin | 2001 |
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Male; Membrane Potentials; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synaptic Transmission; Triazines; Triazoles; Xanthines | 2001 |
Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.
Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Signal Transduction; Synaptic Transmission; Transfection; Triazines; Triazoles; Xanthines | 2002 |
Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.
Topics: Anesthetics; Animals; Animals, Newborn; Anticonvulsants; Carbolines; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Diuretics; Female; Furosemide; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamus; Male; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc; Zolpidem | 2002 |
Spinal gabapentin and antinociception: mechanisms of action.
Topics: Acetates; Adrenergic alpha-Antagonists; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amines; Analgesics; Animals; Atropine; Cyclohexanecarboxylic Acids; Dihydroergocristine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Injections, Spinal; Leucine; Male; Mecamylamine; Muscarinic Antagonists; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nicotinic Antagonists; Pain Measurement; Quinazolines; Rats; Rats, Sprague-Dawley; Serine; Spinal Cord; Thapsigargin; Triazoles | 2003 |
Three drug reviews: one reformulated and one new antifungal agent and optimal dosing of the anticonvulsant gabapentin.
Topics: Acetates; Amines; Amphotericin B; Anticonvulsants; Antifungal Agents; Chemistry, Pharmaceutical; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Humans; Pyrimidines; Triazoles; Voriconazole | 2003 |
Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses.
Topics: Action Potentials; Animals; GABA Agonists; gamma-Aminobutyric Acid; Gene Targeting; In Vitro Techniques; Interneurons; Mice; Mice, Mutant Strains; Neocortex; Neural Inhibition; Patch-Clamp Techniques; Protein Subunits; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Somatosensory Cortex; Synaptic Transmission; Triazoles; Zolpidem | 2003 |
Critically timed ethanol exposure reduces GABAAR function on septal neurons developing in vivo but not in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Body Weight; Cells, Cultured; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Embryo, Mammalian; Ethanol; Female; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Penicillins; Picrotoxin; Pregnancy; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Septum of Brain; Streptomycin; Time Factors; Triazoles; Up-Regulation; Zinc; Zolpidem | 2004 |
AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Benzoxazines; Calcium; Calcium Channel Blockers; Cerebellum; Chelating Agents; Colforsin; Cyclopropanes; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Wistar; Receptors, AMPA; Ryanodine; Synapses; Triazines; Triazoles | 2004 |
High-affinity, slowly desensitizing GABAA receptors mediate tonic inhibition in hippocampal dentate granule cells.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Diuretics; Furosemide; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Neural Inhibition; Penicillins; Pyridines; Rats; Rats, Sprague-Dawley; Triazoles; Zolpidem | 2006 |
Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Electrophysiology; Etomidate; GABA Agonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isomerism; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Triazoles; Xenopus | 2005 |
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
Topics: Acetates; Acrylamides; Animals; Benzyl Compounds; Dimethyl Sulfoxide; Extracellular Fluid; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Male; Mice; Microdialysis; Misoprostol; Naphthalenes; Pain Measurement; Periaqueductal Gray; Prostaglandin Antagonists; Receptors, Prostaglandin E; Thiophenes; Triazoles; Xanthones | 2006 |
Effects of the A 2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo.
Topics: Animals; Binding, Competitive; Conditioning, Operant; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Microdialysis; Motor Activity; Nucleus Accumbens; Purines; Rats; Receptor, Adenosine A2A; Triazines; Triazoles; Xanthines | 2006 |
Dialysis delivery of an adenosine A2A agonist into the pontine reticular formation of C57BL/6J mouse increases pontine acetylcholine release and sleep.
Topics: Acetylcholine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Extracellular Fluid; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Microdialysis; Neural Inhibition; Neural Pathways; Phenethylamines; Pons; Receptor, Adenosine A2A; Reticular Formation; Sleep; Sleep, REM; Synaptic Transmission; Triazines; Triazoles; Up-Regulation; Wakefulness | 2006 |
Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine A2 Receptor Agonists; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Data Interpretation, Statistical; Enzyme Inhibitors; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Globus Pallidus; In Vitro Techniques; Isoquinolines; Male; Okadaic Acid; Phenethylamines; Rats; Rats, Wistar; Sulfonamides; Synapses; Triazines; Triazoles | 2006 |
New drugs 06, part II.
Topics: Analgesics; Benzeneacetamides; Benzoates; Bone Density Conservation Agents; Deferasirox; Diphosphonates; Docosahexaenoic Acids; Drug Approval; Drug Combinations; Drug Interactions; Drug Monitoring; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Eicosapentaenoic Acid; gamma-Aminobutyric Acid; Humans; Ibandronic Acid; Iloprost; Indenes; Minocycline; Patient Education as Topic; Phenylacetates; Pregabalin; Tigecycline; Triazoles; Vasodilator Agents | 2006 |
Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors.
Topics: Animals; Aromatase; Cells, Cultured; Dendritic Spines; Down-Regulation; Enzyme Inhibitors; Epilepsy; Estradiol; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Letrozole; Nerve Degeneration; Neural Inhibition; Neuroprotective Agents; Nitriles; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission; Triazoles | 2007 |
Cardiac conduction disturbances after an overdose of nefazodone and gabapentin.
Topics: Adult; Amines; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Cyclohexanecarboxylic Acids; Drug Overdose; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Piperazines; Tachycardia, Sinus; Triazoles | 2006 |
The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antipsychotic Agents; Caffeine; Catalepsy; Cebus; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Globus Pallidus; Haloperidol; Neurologic Examination; Purines; Pyrimidines; Receptor, Adenosine A2A; Saimiri; Triazoles; Xanthines | 2008 |
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
Topics: Adenosine; Adenosine Deaminase; Adult; Animals; Anticonvulsants; Cerebral Cortex; Epilepsy; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Male; Neurons; Oocytes; Purinergic P1 Receptor Antagonists; Pyramidal Tracts; Pyrimidines; Quinazolines; Rats; Receptors, GABA-A; Triazoles; Xanthines; Xenopus | 2008 |
A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.
Topics: Carbolines; Cell Culture Techniques; Cell Line; Cell Membrane; Cryopreservation; Diazepam; DNA; Dose-Response Relationship, Drug; Drug Discovery; Flumazenil; Flunitrazepam; Fluorescent Dyes; Fluorobenzenes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Receptors, GABA-A; Reproducibility of Results; Spectrometry, Fluorescence; Transfection; Triazoles; Tritium | 2008 |
GABA regulates the rat hypothalamic-pituitary-adrenocortical axis via different GABA-A receptor alpha-subtypes.
Topics: Animals; Brain; Corticotropin-Releasing Hormone; Diazepam; Fluorobenzenes; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamo-Hypophyseal System; Male; Neural Pathways; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Protein Subunits; Proto-Oncogene Proteins c-fos; Pyridines; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Triazoles; Zolpidem | 2008 |
Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Convulsants; Electroshock; Enzyme Activation; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Postural Balance; Quinolines; Seizures; Synaptic Transmission; Triazoles | 2009 |
Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
Topics: Amines; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Cyclohexanecarboxylic Acids; Diazepam; Endpoint Determination; GABA Antagonists; GABA Modulators; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Pain; Physical Stimulation; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 2012 |
Synthesis and anticonvulsant activity evaluation of 4-(2-alkoxy-phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones in various experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Seizures; Triazoles | 2013 |
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition.
Topics: Administration, Oral; Animals; Attention; Azabicyclo Compounds; Choice Behavior; Cognition; Cytoskeletal Proteins; Diazepam; Eszopiclone; gamma-Aminobutyric Acid; Hippocampus; Hypnotics and Sedatives; Macaca mulatta; Male; Memory, Short-Term; Nerve Tissue Proteins; Orexin Receptors; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Recognition, Psychology; Sleep; Task Performance and Analysis; Time Factors; Triazoles; Zolpidem | 2013 |
Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Globus Pallidus; Hypokinesia; Male; Mice; Mice, Inbred Strains; Motor Activity; Parkinsonian Disorders; Protein Binding; Pyrimidines; Receptor, Adenosine A2A; Rotarod Performance Test; Triazoles | 2014 |
In vitro transport assays of rufinamide, pregabalin, and zonisamide by human P-glycoprotein.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Transformed; Dogs; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression; Humans; Isoxazoles; Pregabalin; Rhodamine 123; Swine; Transfection; Triazoles; Zonisamide | 2014 |
Histamine H3 receptor activation counteracts adenosine A2A receptor-mediated enhancement of depolarization-evoked [3H]-GABA release from rat globus pallidus synaptosomes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Biphenyl Compounds; gamma-Aminobutyric Acid; Globus Pallidus; Histamine Agonists; Histamine H3 Antagonists; Imidazoles; Male; Membrane Potentials; Nitriles; Phenethylamines; Piperidines; Potassium; Pyrrolidines; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Histamine H3; Synaptosomes; Thiourea; Triazines; Triazoles; Tritium | 2014 |
On the role of adenosine (A)₂A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Basal Forebrain; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Phenethylamines; Purines; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reinforcement, Psychology; Reward; Self Administration; Triazoles | 2015 |
Involvement of glutamatergic and GABAergic transmission in MK-801-increased gamma band oscillation power in rat cortical electroencephalograms.
Topics: Amino Acids; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Excitatory Amino Acid Antagonists; Fluorobenzenes; GABA Agents; Gamma Rhythm; gamma-Aminobutyric Acid; Glutamic Acid; Haloperidol; Male; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Riluzole; Triazoles | 2014 |
Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Brain-Derived Neurotrophic Factor; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Phenethylamines; Potassium; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Synaptosomes; Triazoles | 2015 |
The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.
Topics: Acetylcholine; Animals; gamma-Aminobutyric Acid; Hippocampus; Histamine; Hypothalamic Area, Lateral; Male; Orexin Receptor Antagonists; Piperidines; Prefrontal Cortex; Rats; Sleep; Sleep Initiation and Maintenance Disorders; Triazoles; Wakefulness | 2017 |
Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats.
Topics: Androgen Antagonists; Animals; Blood Glucose; Body Weight; Catalase; Estradiol; Female; gamma-Aminobutyric Acid; Insulin Resistance; Letrozole; Nitriles; Ovary; Peroxidase; Polycystic Ovary Syndrome; Protective Agents; Rats; Reproduction; Superoxide Dismutase; Testosterone; Triazoles | 2017 |
Alterations in Rat Accumbens Endocannabinoid and GABA Content during Fentanyl Treatment: The Role of Ghrelin.
Topics: Animals; Behavior, Animal; Endocannabinoids; Extracellular Space; Fentanyl; gamma-Aminobutyric Acid; Ghrelin; Glycine; Male; Nucleus Accumbens; Rats; Receptors, Ghrelin; Triazoles; Ventral Tegmental Area | 2017 |
GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile.
Topics: Acetylcholine; Animals; Dopamine; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Hippocampus; Hypothalamus; Letrozole; Neurotransmitter Agents; Nitriles; Pituitary Gland; Polycystic Ovary Syndrome; Rats; Rats, Inbred Strains; Serotonin; Triazoles | 2018 |
4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site.
Topics: Animals; Binding Sites; gamma-Aminobutyric Acid; Humans; Hydroxylation; Male; Models, Molecular; Protein Binding; Rats; Receptors, GABA-A; Structure-Activity Relationship; Triazoles | 2018 |
Alterations in Rat Accumbens Dopamine, Endocannabinoids and GABA Content During WIN55,212-2 Treatment: The Role of Ghrelin.
Topics: Animals; Arachidonic Acids; Benzoxazines; Dopamine; Drug Evaluation, Preclinical; Endocannabinoids; gamma-Aminobutyric Acid; Ghrelin; Glycerides; Glycine; Male; Morpholines; Naphthalenes; Nucleus Accumbens; Polyunsaturated Alkamides; Rats, Wistar; Triazoles | 2020 |